Dexrazoxane hydrochlorideProduct ingredient for Dexrazoxane
- Name
- Dexrazoxane hydrochloride
- Drug Entry
- Dexrazoxane
An antimitotic agent with immunosuppressive properties. Dexrazoxane, the (+)-enantiomorph of razoxane, provides cardioprotection against anthracycline toxicity. It appears to inhibit formation of a toxic iron-anthracycline complex. [PubChem] The Food and Drug Administration has designated dexrazoxane as an orphan drug for use in the prevention or reduction in the incidence and severity of anthracycline-induced cardiomyopathy.
- Accession Number
- DBSALT001028
- Structure
Structure for Dexrazoxane hydrochloride (DBSALT001028)
- Synonyms
- Dexrazoxane HCl
- UNII
- 5346058Q7S
- CAS Number
- 149003-01-0
- Weight
- Average: 304.73
Monoisotopic: 304.0938327 - Chemical Formula
- C11H17ClN4O4
- InChI Key
- BIFMNMPSIYHKDN-FJXQXJEOSA-N
- InChI
- InChI=1S/C11H16N4O4.ClH/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14;/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19);1H/t7-;/m0./s1
- IUPAC Name
- 4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione hydrochloride
- SMILES
- Cl.C[C@@H](CN1CC(=O)NC(=O)C1)N1CC(=O)NC(=O)C1
- External Links
- ChemSpider
- 5293431
- ChEBI
- 50224
- ChEMBL
- CHEMBL1200778
- Wikipedia
- Dexrazoxane
- Predicted Properties
Property Value Source Water Solubility 10.4 mg/mL ALOGPS logP -1 ALOGPS logP -2.7 Chemaxon logS -1.4 ALOGPS pKa (Strongest Acidic) 11.2 Chemaxon pKa (Strongest Basic) 3.2 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 98.82 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 64.25 m3·mol-1 Chemaxon Polarizability 25.51 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon