Arformoterol tartrateProduct ingredient for Arformoterol
- Name
- Arformoterol tartrate
- Drug Entry
- Arformoterol
Arformoterol is a bronchodilator. It works by relaxing muscles in the airways to improve breathing. Arformoterol inhalation is used to prevent bronchoconstriction in people with chronic obstructive pulmonary disease, including chronic bronchitis and emphysema. The use of arformoterol is pending revision due to safety concerns in regards to an increased risk of severe exacerbation of asthma symptoms, leading to hospitalization as well as death in some patients using long-acting beta agonists for the treatment of asthma.
- Accession Number
- DBSALT001387
- Structure
Structure for Arformoterol tartrate (DBSALT001387)
- Synonyms
- Not Available
- UNII
- 5P8VJ2I235
- CAS Number
- 200815-49-2
- Weight
- Average: 494.497
Monoisotopic: 494.190045174 - Chemical Formula
- C23H30N2O10
- InChI Key
- FCSXYHUNDAXDRH-OKMNHOJOSA-N
- InChI
- InChI=1S/C19H24N2O4.C4H6O6/c1-13(9-14-3-6-16(25-2)7-4-14)20-11-19(24)15-5-8-18(23)17(10-15)21-12-22;5-1(3(7)8)2(6)4(9)10/h3-8,10,12-13,19-20,23-24H,9,11H2,1-2H3,(H,21,22);1-2,5-6H,(H,7,8)(H,9,10)/t13-,19+;1-,2-/m11/s1
- IUPAC Name
- (2R,3R)-2,3-dihydroxybutanedioic acid; N-{2-hydroxy-5-[(1R)-1-hydroxy-2-{[(2R)-1-(4-methoxyphenyl)propan-2-yl]amino}ethyl]phenyl}formamide
- SMILES
- O[C@H]([C@@H](O)C(O)=O)C(O)=O.COC1=CC=C(C[C@@H](C)NC[C@H](O)C2=CC=C(O)C(NC=O)=C2)C=C1
- External Links
- ChemSpider
- 8002804
- Predicted Properties
Property Value Source Water Solubility 0.0416 mg/mL ALOGPS logP 1.91 ALOGPS logP 1.06 Chemaxon logS -3.9 ALOGPS pKa (Strongest Acidic) 8.61 Chemaxon pKa (Strongest Basic) 9.81 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 4 Chemaxon Polar Surface Area 90.82 Å2 Chemaxon Rotatable Bond Count 11 Chemaxon Refractivity 97.87 m3·mol-1 Chemaxon Polarizability 37.8 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon