Meropenem sodiumProduct ingredient for Meropenem
- Name
- Meropenem sodium
- Drug Entry
- Meropenem
Meropenem is a broad-spectrum carbapenem antibiotic. It is active against Gram-positive and Gram-negative bacteria. Meropenem exerts its action by penetrating bacterial cells readily and interfering with the synthesis of vital cell wall components, which leads to cell death.
In August 2017, a combination antibacterial therapy under the market name vabomere was approved for treatment of adult patients with complicated urinary tract infections (cUTI). Vabomere consists of meropenem and Vaborbactam and is intravenously admininstered. The treatment aims to resolve infection-related symptoms and achieve negative urine culture, where the infections are proven or strongly suspected to be caused by susceptible bacteria.
- Accession Number
- DBSALT002981
- Structure
Structure for Meropenem sodium (DBSALT002981)
- Synonyms
- Not Available
- UNII
- Not Available
- CAS Number
- 211238-34-5
- Weight
- Average: 406.45
Monoisotopic: 406.14071279 - Chemical Formula
- C17H25N3NaO5S
- InChI Key
- UBQRNADYCUXRBD-NACOAMSHSA-N
- InChI
- InChI=1S/C17H25N3O5S.Na/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4;/h7-12,18,21H,5-6H2,1-4H3,(H,24,25);/q;+1/t7-,8-,9+,10+,11-,12-;/m1./s1
- IUPAC Name
- sodium (4R,5S,6S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
- SMILES
- [Na+].[H][C@]1([C@@H](C)O)C(=O)N2C(C(O)=O)=C(S[C@@H]3CN[C@@H](C3)C(=O)N(C)C)[C@H](C)[C@]12[H]
- External Links
- Not Available
- Predicted Properties
Property Value Source Water Solubility 5.63 mg/mL ALOGPS logP -0.69 ALOGPS logP -4.4 Chemaxon logS -1.8 ALOGPS pKa (Strongest Acidic) 3.28 Chemaxon pKa (Strongest Basic) 9.39 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 110.18 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 97.89 m3·mol-1 Chemaxon Polarizability 39.29 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon