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Displaying drugs 26 - 50 of 191 in total
Cold agglutinin disease (CAD) is a type of autoimmune hemolytic anemia (AIHA) in which autoantibodies directed against red blood cell surface antigens cause hemolysis at low (3-4°C) temperatures.[A245154,L40114] This cold subtype accounts for approximately 15-25% of all AIHA and is more common in the elderly.[A245159,L40114] In approximately 90% of cases,...
Approved
Investigational
Matched Description: … on erythrocytes - these antibodies react optimally at 4°C and are therefore referred to as "cold agglutinin ... [A245159] Pharmacologic strategies have included the targeting of B-cells with agents like [rituximab ... In approximately 90% of cases, patients develop immunoglobulin M (IgM) autoantibodies towards the I antigen
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-controlled, hydrogel polymer reservoirs containing histrelin acetate that...
Approved
Withdrawn
Matched Iupac: … ]propanamido]-3-(4-hydroxyphenyl)propanamido]propanamido]-4-methylpentanamido]-5-carbamimidamidopentanoyl ... (2S)-1-[(2S)-2-[(2S)-2-[(2R)-3-(1-benzyl-1H-imidazol-4-yl)-2-[(2S)-2-[(2S)-3-hydroxy-2-[(2S)-2-[(2S)- ... 3-(1H-imidazol-4-yl)-2-{[(2S)-5-oxopyrrolidin-2-yl]formamido}propanamido]-3-(1H-indol-3-yl)propanamido …
Matched Description: … treatment for children with central precocious puberty (CPP) due to their capacity to reduce LH levels and
Matched Categories: … Hormones and Related Agents ... Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Durvalumab is a human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody and a novel immune-checkpoint inhibitor for cancer treatment. Produced by recombinant DNA technology in Chinese Hamster Ovary (CHO) cell suspension culture, durvalumab is a programmed death-ligand 1 (PD-L1) blocking antibody that works to promote normal immune responses that attack tumour...
Approved
Investigational
Matched Description: … Durvalumab is a human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody and a novel immune-checkpoint ... unresectable non-small cell lung cancer (NSCLC), only if PD-L1 is expressed in ≥ 1% of tumour cells and ... L12627] On March 27, 2020, durvalumab was approved by the FDA for use in combination with [etoposide] and
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Gallium (Ga) 68 prostate-specific membrane antigen (PSMA)-11, or Ga-68 gozetotide, is a radiopharmaceutical agent used to identify and assess prostate-specific membrane antigen (PSMA)-positive lesions in adult men with prostate cancer during positron emission tomography (PET). Prostate cancer is one of the most commonly diagnosed cancers among men in Western countries...
Approved
Matched Iupac: … carbamoyl]ethyl}-2-hydroxyphenyl)methyl](carboxylatomethyl)amino}ethyl)(carboxylatomethyl)amino]methyl}-4- …
Matched Description: … agent used to identify and assess prostate-specific membrane antigen (PSMA)-positive lesions in adult ... In October 2022, the EMA's Committee for Medicinal Products for Human Use (CHMP) recommended Ga-68 gozetotide ... L26981] Prostate cancer is one of the most commonly diagnosed cancers among men in Western countries and
Matched Categories: … Indicators and Reagents …
Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Resistant Prostate Cancer, and Prostatic...
Approved
Investigational
Matched Iupac: … 4-{7-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.4]octan-5-yl}-2 …
Matched Description: … Higher prostate-specific antigen (PSA) and shorter PSA doubling time (PSA DT) are associated with a higher ... Unlike bicalutamide, apalutamide antagonized AR-mediated signaling in AR overexpressing human CRPC cell ... In mice bearing human CRPC xenograft models, apalutamide treatment produced tumor regressions in a dose-dependent …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Hormone Antagonists and Related Agents …
Avelumab is a human IgG1 lambda monoclonal antibody that binds programmed cell death ligand-1 (PD-L1) to block its interaction with its receptors found on T cells and antigen-presenting cells. Avelumab was first approved by the FDA on March 23, 2017. On September 18 and December 18 of the same year,...
Approved
Investigational
Matched Description: … to block its interaction with its receptors found on T cells and antigen-presenting cells. ... Avelumab is a human IgG1 lambda monoclonal antibody that binds programmed cell death ligand-1 (PD-L1) ... ] and Health Canada,[L48171] respectively. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Talimogene laherparepvec is an oncolytic treatment used in local treatment of unresectable cutaneous, subcutaneous, and nodal lesions in patients with recurrent melanoma. It is a genetically administered herpes simplex virus 1 (HSV-1) that expresses human cytokine granulocyte-macrophage colony stimulating factor (GM-CSF) with antitumor and immune-stimulating activities. It specifically replicates within...
Approved
Experimental
Investigational
Matched Description: … It is a genetically administered herpes simplex virus 1 (HSV-1) that expresses human cytokine granulocyte-macrophage ... It specifically replicates within tumor cells and causes lysis. ... colony stimulating factor (GM-CSF) with antitumor and immune-stimulating activities. …
Matched Categories: … Antineoplastic cell and gene therapy ... Antineoplastic and Immunomodulating Agents …
Metastatic triple-negative breast cancer (mTNBC) is an aggressive form of breast cancer with limited treatment options involving cytotoxic chemotherapy agents. Targeted chemotherapy through the application of antibody-conjugated agents (ADCs) is a recent advance in cancer treatment. One such ADC is sacituzumab govitecan, which combines a humanized anti-trophoblast cell-surface antigen 2...
Approved
Investigational
Matched Description: … A193671] One such ADC is sacituzumab govitecan, which combines a humanized anti-trophoblast cell-surface antigen ... Commission and Health Canada respectively. ... [L13002, A193674] Sacituzumab govitecan was granted FDA approval on April 22nd, 2020 and is marketed …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Inactivated rabies virus antigen B is a component of rabies vaccines used for pre- and post-exposure prophylaxis against rabies.
Approved
Matched Synonyms: … Rabies virus vaccine wistar strain PM-1503-3M (human) ... Rabies virus strain PM-1503-3M antigen (propiolactone inactivated) …
Matched Name: … Rabies virus inactivated antigen, B
Matched Description: … Inactivated rabies virus antigen B is a component of rabies vaccines used for pre- and post-exposure …
Matched Categories: … Immune Sera and Immunoglobulins …
Matched Products: … RABIES VACCINE FOR HUMAN USE (VERO CELL), FREEZE-DRIED FINAL BULK …
Human papillomavirus type 33 L1 capsid protein antigen is contained in Gardasil is a vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus (HPV) type 33. The vaccine is prepared from the purified...
Approved
Matched Synonyms: … L1 protein, Human papillomavirus type 33 Vaccine ... Recombinant human papillomavirus type 33 L1 protein …
Matched Name: … Human papillomavirus type 33 L1 capsid protein antigen
Matched Description: … Human papillomavirus type 33 L1 capsid protein antigen is contained in Gardasil is a vaccine for intramuscular ... by Human Papillomavirus (HPV) type 33. ... It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused …
Matched Mixtures name: … Gardasil 9 [Human Papillomavirus 9-valent Vaccine, Recombinant] …
Human papillomavirus type 6 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus...
Approved
Investigational
Matched Synonyms: … L1 protein, Human papillomavirus type 6 Vaccine ... Recombinant human papillomavirus type 6 L1 protein …
Matched Name: … Human papillomavirus type 6 L1 capsid protein antigen
Matched Description: … Human papillomavirus type 6 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human ... by Human Papillomavirus (HPV) types 6, 11, 16 and 18. ... Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. …
Matched Mixtures name: … Gardasil 9 [Human Papillomavirus 9-valent Vaccine, Recombinant] …
Matched Categories: … Inactivated Human Papillomavirus Vaccine …
Human papillomavirus type 16 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus...
Approved
Investigational
Matched Synonyms: … L1 protein, Human papillomavirus type 16 Vaccine ... Recombinant human papillomavirus type 16 L1 protein …
Matched Name: … Human papillomavirus type 16 L1 capsid protein antigen
Matched Description: … Human papillomavirus type 16 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human ... by Human Papillomavirus (HPV) types 6, 11, 16 and 18. ... Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. …
Matched Mixtures name: … Gardasil 9 [Human Papillomavirus 9-valent Vaccine, Recombinant] …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Human papillomavirus 16 ... Inactivated Human Papillomavirus Vaccine …
Human Rho(D) immune globulin is a medicine given by intramuscular or intravenous injection that is used to prevent the immunological condition known as Rh disease (or hemolytic disease of newborn). Rho (D) immune globulin is available as a sterile, lyophilized or liquid gamma globulin (IgG) fraction containing antibodies to the...
Approved
Investigational
Matched Synonyms: … Human anti-D immunoglobulin ... Immunoglobulin human anti-RH ... Rho D immune globulin human
Matched Name: … Human Rho(D) immune globulin …
Matched Description: … Immune globullin was purified via ion-exchange chromatography method and prepared from pools of human ... (D antigen) under the name Rhophylac (IM/IV). ... Human Rho(D) immune globulin is a medicine given by intramuscular or intravenous injection that is used …
Matched Categories: … Human Immunoglobulin G ... Endogenous Antigen Neutralization ... Amino Acids, Peptides, and Proteins ... Immune Sera and Immunoglobulins …
Human cord blood hematopoietic progenitor cells consist of hematopoietic progenitor cells, monocytes, lymphocytes, and granulocytes from human cord blood. They are used during allogeneic unrelated and related hematopoietic stem cell transplantation procedures in patients with disorders affecting the hematopoietic system that are inherited, acquired, or result from myeloablative treatment. Human...
Approved
Matched Name: … Human cord blood hematopoietic progenitor cell …
Matched Description: … marrow transplantation; it allows shorter time to transplant and tolerance of 1–2 human leukocyte antigen ... lymphocytes, and granulocytes from human cord blood. ... Human umbilical cord is a rich source of hematopoietic stem cells and progenitor cells that are capable …
Approved
Investigational
Matched Name: … Human papillomavirus type 18 L1 capsid protein residues 2-472 antigen
Talquetamab is a IgG4-PAA bispecific G protein-coupled receptor class C group 5 member D (GPRC5D)-directed CD3 T-cell engager. It consists of two arms - anti-GPRC5D and anti-CD3 arms - linked by two interchain disulfide bonds, each arm comprising a heavy and light chain. Talquetamab binds to GPRC5D, a cell surface...
Approved
Investigational
Matched Synonyms: … IMMUNOGLOBULIN G4 (233-PROLINE,239-ALANINE,240-ALANINE,410-LEUCINE,414-LYSINE), ANTI-(HUMAN CD3 ANTIGEN ... ) (HUMAN MONOCLONAL JNJ-63483043 .GAMMA.4-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL JNJ-63483043 .LAMBDA ... ANTI-(HOMO SAPIENS CD3E (CD3 EPSILON, LEU-4)), HUMANIZED AND CHIMERIC MONOCLONAL ANTIBODY, BISPECIFIC …
Matched Description: … [A260890] The Committee for Medicinal Products for Human Use (CHMP) of the EMA recommended conditional ... arm comprising a heavy and light chain. ... It consists of two arms - anti-GPRC5D and anti-CD3 arms - linked by two interchain disulfide bonds, each …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Bordetella pertussis toxoid antigen (formaldehyde, glutaraldehyde inactivated) is a vaccine that is used in the prophylaxis of Pertussis (whooping cough), which is caused by a small Gram-negative coccobacillus that infects the mucosal layers of the human respiratory tract.
Approved
Matched Name: … Bordetella pertussis toxoid antigen (formaldehyde, glutaraldehyde inactivated) …
Matched Description: … Bordetella pertussis toxoid antigen (formaldehyde, glutaraldehyde inactivated) is a vaccine that is used ... cough), which is caused by a small Gram-negative coccobacillus that infects the mucosal layers of the human
Relapsed and refractory B-cell acute lymphoblastic leukemia (B-ALL) are a therapeutic challenge for patients who have undergone prior systemic therapies with limited success. Prognosis is poor and more effective therapies are needed to treat relapsed/refractory cases and improve survival. On April 23 2021, the Food and Drug Administration granted accelerated...
Approved
Investigational
Matched Synonyms: … Humanized monoclonal immunoglobulin G1 antibody directed against human CD19 conjugated to SG3199 through …
Matched Description: … Relapsed and refractory B-cell acute lymphoblastic leukemia (B-ALL) are a therapeutic challenge for patients ... and improve survival. ... refractory B-cell lymphoma is based on promising results from the LOTIS-2 clinical trial. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Approved
Vet approved
Matched Synonyms: … H-17-B ... 11β,21-dihydroxy-17α-butyryloxy-4-pregnene-3,20-dione …
Matched Iupac: … (1R,3aS,3bS,9aR,9bS,10S,11aS)-10-hydroxy-1-(2-hydroxyacetyl)-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H …
Matched Categories: … Hydrocortisone and derivatives ... hydrocortisone butyrate and antiseptics ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Human Interferon gamma-1b (140 residues), produced from E. coli. Production of Actimmune is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein. Purification of the product is achieved by conventional column chromatography. The sequence displayed is a cDNA sequence which...
Approved
Investigational
Matched Synonyms: … Interferon gamma 1-b
Matched Description: … Human Interferon gamma-1b (140 residues), produced from E. coli. ... et. al. and not specifically interferon gamma 1b. ... The sequence displayed is a cDNA sequence which codes for human interferon gamma, as described by Gray …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Intercellular Signaling Peptides and Proteins …
A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine.
Approved
Matched Synonyms: … γ-(4-chlorophenyl)-γ-(2-pyridyl)propyldimethylamine ... γ-(4-chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine …
Matched Iupac: … [3-(4-chlorophenyl)-3-(pyridin-2-yl)propyl]dimethylamine …
Matched Description: … A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. ... One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and
Matched Salts cas: … 1405-56-7 ... 56343-98-7
Matched Mixtures name: … ACT 7 ... Altilan CL ... DAYFLU B
Matched Products: … AXCEL CHLORPHENIRAMINE-4 SYRUP 4 mg/5 ml ... คลอเฟน 4 ... SELMETOR 4
Tuberculin Purified Protein Derivative (PPD) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The diagnostic test is commonly referred to as the Mantoux test which serves to minimize the risk of transmission of infection with Mycobacterium tuberculosis...
Approved
Matched Description: … The purified protein fraction is isolated from culture media filtrates of a human strain of Mycobacterium ... minimize the risk of transmission of infection with *Mycobacterium tuberculosis* through early diagnosis and
Matched Categories: … Skin Test Antigen ... Indicators and Reagents ... Amino Acids, Peptides, and Proteins …
Raxibacumab is a human IgG1λ monoclonal antibody that binds the protective antigen (PA) component of B. anthracis toxin. Raxibacumab has a molecular weight of approximately 146 kilodaltons. Raxibacumab is produced by recombinant DNA technology in a murine cell expression system. FDA approved on December 14, 2012.
Approved
Matched Description: … Raxibacumab is a human IgG1λ monoclonal antibody that binds the protective antigen (PA) component of ... B. anthracis toxin. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Immune Sera and Immunoglobulins ... Anthrax Protective Antigen-directed Antibody ... Anthrax Protective Antigen-directed Antibody Interactions …
Pitavastatin, also known as the brand name product Livalo, is a lipid-lowering drug belonging to the statin class of medications. By inhibiting the endogenous production of cholesterol within the liver, statins lower abnormal cholesterol and lipid levels and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competitively...
Approved
Matched Iupac: … (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid …
Matched Description: … lipid levels and ultimately reduce the risk of cardiovascular disease. ... studies to significantly reduce the risk of development of CVD and all-cause mortality. ... inhibiting the endogenous production of cholesterol within the liver, statins lower abnormal cholesterol and
Matched Salts cas: … 147526-32-7
Matched Products: … Trolise 4 mg Filmtabletten ... ALIPZA 4 MG FILM KAPLI TABLET, 90 ADET ... ALIPZA 4 MG FILM KAPLI TABLET, 30 ADET …
Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes.[A35065,A35080,L12126] Ipilimumab was developed by Bristol-Myers Squibb and Medarex. Ipilimumab was granted FDA approval on 25 March 2011.
Approved
Matched Description: … Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 ... [A35065,A35080,L12126] Ipilimumab was developed by Bristol-Myers Squibb and Medarex. ... (CTLA-4). …
Matched Categories: … CTLA-4-directed Blocking Antibody ... CTLA-4-directed Antibody Interactions ... Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Displaying drugs 26 - 50 of 191 in total