Displaying drugs 151 - 175 of 192 in total
Verpasep caltespen
Verpasep caltespen is a recombinant chimeric protein composed of the heat shock protein 65 (Hsp65) from Mycobacterium bovis, and the human papilloma viral (HPV) protein E7. Hsp65, similar to other members of its family of proteins, elicits a strong immune response and may be used to design vaccines against a...
Investigational
Matched Synonyms: … Recombinant fusion protein of Mycobacterium bovis BCG Hsp65 and HPV16 E7 ... Heat-shock protein HSP 65 (Mycobacterium BCG) fusion protein with transcription factor E7 (human papillomavirus …
Matched Description: … E7 protein is involved in carcinogenesis of anal and cervical tumors, and represents a tumor antigen ... _Mycobacterium bovis_, and the human papilloma viral (HPV) protein E7. ... Hsp65, similar to other members of its family of proteins, elicits a strong immune response and may be …
Matched Description: … E7 protein is involved in carcinogenesis of anal and cervical tumors, and represents a tumor antigen ... _Mycobacterium bovis_, and the human papilloma viral (HPV) protein E7. ... Hsp65, similar to other members of its family of proteins, elicits a strong immune response and may be …
Labetuzumab
Labetuzumab is a humanized monoclonal antibody to carcinoembryonic antigen that inhibits tumor growth. It is used in radioimmunotherapy.
Investigational
Matched Synonyms: … MN14 monoclonal antibody to carcinoembryonic antigen …
Matched Description: … Labetuzumab is a humanized monoclonal antibody to carcinoembryonic antigen that inhibits tumor growth …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Description: … Labetuzumab is a humanized monoclonal antibody to carcinoembryonic antigen that inhibits tumor growth …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Girentuximab
Girentuximab is a monoclonal chimeric (mouse/human) antibody directed against carbonic anhydrase IX, an antigen expressed in 95% of clear cell renal cell carcinomas (RCC).
Investigational
Matched Synonyms: … Chimeric (human-murine) G250 IgG monoclonal antibody …
Matched Description: … Girentuximab is a monoclonal chimeric (mouse/human) antibody directed against carbonic anhydrase IX, ... an antigen expressed in 95% of clear cell renal cell carcinomas (RCC). …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Description: … Girentuximab is a monoclonal chimeric (mouse/human) antibody directed against carbonic anhydrase IX, ... an antigen expressed in 95% of clear cell renal cell carcinomas (RCC). …
Matched Categories: … Amino Acids, Peptides, and Proteins …
SEA-BCMA
Investigational
Matched Synonyms: … Nonfucosylated humanized immunoglobulin G1 (IgG1) monoclonal antibody targeting B-cell maturation antigen …
Inbakicept
Inbakicept is a dimeric human IL-15 receptor α (IL-15Rα) sushi domain/human IgG1 Fc fusion protein. It is one of the active ingredients in Anktiva, a combination product also containing nogapendekin alfa, where a single inbakicept is complexed with two nogapendekin alfa components. This combination product was approved by the FDA...
Investigational
Matched Synonyms: … INTERLEUKIN 15 RECEPTOR SUBUNIT ALPHA (HUMAN IL15R.ALPHA.) (1-65)-PEPTIDE (SUSHI DOMAIN-CONTAINING) FUSION ... FRAGMENT (232 C-TERMINAL RESIDUES) (66-297) (HOMO SAPIENS IGHG1*01, HINGE (71-80), CH2 (81-190), CH3 (191-2 ... CHAIN (HUMAN SUSHI DOMAIN-CONTAINING FRAGMENT) FUSION PROTEIN WITH IMMUNOGLOBULIN G1 (HUMAN FC FRAGMENT …
Matched Description: … Inbakicept is a dimeric human IL-15 receptor α (IL-15Rα) sushi domain/human IgG1 Fc fusion protein. ... 75% of all bladder tumours, is commonly treated with transurethral resection of the bladder tumour and ... ], where a single inbakicept is complexed with two nogapendekin alfa components. …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Description: … Inbakicept is a dimeric human IL-15 receptor α (IL-15Rα) sushi domain/human IgG1 Fc fusion protein. ... 75% of all bladder tumours, is commonly treated with transurethral resection of the bladder tumour and ... ], where a single inbakicept is complexed with two nogapendekin alfa components. …
Matched Categories: … Amino Acids, Peptides, and Proteins …
RLYB212
RLYB212 is a human monoclonal antibody against Antigen-1A Immunoglobulin (HPA-1A). It is currently being developed by Rallybio for the prevention of fetal and neonatal alloimmune thrombocytopenia.
Investigational
Matched Synonyms: … Recombinant human IgG monoclonal HPA-1a antibody …
Matched Description: … RLYB212 is a human monoclonal antibody against Antigen-1A Immunoglobulin (HPA-1A). ... It is currently being developed by Rallybio for the prevention of fetal and neonatal alloimmune thrombocytopenia …
Matched Description: … RLYB212 is a human monoclonal antibody against Antigen-1A Immunoglobulin (HPA-1A). ... It is currently being developed by Rallybio for the prevention of fetal and neonatal alloimmune thrombocytopenia …
105AD7
105AD7 is a human monoclonal antibody that mimics the complement regulatory protein, CD55, overexpressed by many solid tumours including osteosarcoma. 105AD7 induced antitumour inflammatory responses in metastatic colorectal cancer patients. 105AD7 may be a suitable vaccine for treatment of this disease.
Investigational
Matched Description: … 105AD7 is a human monoclonal antibody that mimics the complement regulatory protein, CD55, overexpressed ... 105AD7 induced antitumour inflammatory responses in metastatic colorectal cancer patients. 105AD7 may be a …
Leukotriene C4
The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates mucus secretion in the lung, and produces contractions of nonvascular and some vascular smooth muscle. (From Dictionary of Prostaglandins and...
Experimental
Investigational
Matched Synonyms: … L-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]pentadeca-2,4,6,9-tetraen-1-yl]-L-cysteinylglycine ... (R-(R*,S*-(E,E,Z,Z)))-N-(S-(1-(4-Carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-N-L-gamma-glutamyl-L-cysteinyl ... LTC (sub 4) …
Matched Iupac: … (5S,6R,7E,9E,11Z,14Z)-6-{[(2R)-2-[(4S)-4-amino-4-carboxybutanamido]-2-[(carboxymethyl)carbamoyl]ethyl ... ]sulfanyl}-5-hydroxyicosa-7,9,11,14-tetraenoic acid …
Matched Description: … It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized ... It stimulates mucus secretion in the lung, and produces contractions of nonvascular and some vascular ... The conjugation product of LEUKOTRIENE A4 and glutathione. …
Matched Categories: … SRS-A …
Matched Iupac: … (5S,6R,7E,9E,11Z,14Z)-6-{[(2R)-2-[(4S)-4-amino-4-carboxybutanamido]-2-[(carboxymethyl)carbamoyl]ethyl ... ]sulfanyl}-5-hydroxyicosa-7,9,11,14-tetraenoic acid …
Matched Description: … It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized ... It stimulates mucus secretion in the lung, and produces contractions of nonvascular and some vascular ... The conjugation product of LEUKOTRIENE A4 and glutathione. …
Matched Categories: … SRS-A …
Iratumumab
Immunoglobulin G1, anti-(human CD30 (antigen)) (human monoclonal MDX-060 heavy chain), disulfide with human monoclonal MDX-060 light chain, dimer. Molecular weight is approximately 170,000 daltons. In phase I/II clinical trials for treatment of CD30+ lymphomas.
Investigational
Matched Description: … Immunoglobulin G1, anti-(human CD30 (antigen)) (human monoclonal MDX-060 heavy chain), disulfide with ... human monoclonal MDX-060 light chain, dimer. …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
MK-4721
MK-4721 is a fully human monoclonal antibody directed to Agensys’ proprietary target Prostate Stem Cell Antigen (PSCA), an antigen expressed at significant levels on tumor cells from the majority of patients with all stages of prostate, pancreatic and bladder cancers.
Investigational
Matched Description: … MK-4721 is a fully human monoclonal antibody directed to Agensys’ proprietary target Prostate Stem Cell ... with all stages of prostate, pancreatic and bladder cancers. ... Antigen (PSCA), an antigen expressed at significant levels on tumor cells from the majority of patients …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Oregovomab
Oregovomab is a murine monoclonal antibody that attaches to the tumor-associated antigen CA125.
Investigational
Matched Description: … Oregovomab is a murine monoclonal antibody that attaches to the tumor-associated antigen CA125. …
Matched Categories: … CA-125 Antigen ... Amino Acids, Peptides, and Proteins …
Matched Categories: … CA-125 Antigen ... Amino Acids, Peptides, and Proteins …
Technetium Tc-99m arcitumomab
Reduced Fab fragment of the murine IgG1 monoclonal antibody IMMU-4 (also called NP-4) with specificity for carcinoembryonic antigen (CEA) covalently labeled with Technitium 99. The molecule has a molecular weight of ~54,000 Daltons.
Experimental
Matched Description: … The molecule has a molecular weight of ~54,000 Daltons. ... for carcinoembryonic antigen (CEA) covalently labeled with Technitium 99. ... Reduced Fab fragment of the murine IgG1 monoclonal antibody IMMU-4 (also called NP-4) with specificity …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
AMG-553
AMG-553 is an adoptive, anti-FLT3 chimeric antigen receptor T-cell therapy generated through transduction of autologous T-cells with a self-inactivating human immunodeficiency virus-1 based lentiviral vector.
Investigational
Matched Description: … of autologous T-cells with a self-inactivating human immunodeficiency virus-1 based lentiviral vector ... AMG-553 is an adoptive, anti-FLT3 chimeric antigen receptor T-cell therapy generated through transduction …
TG4010
A bivalent cancer vaccine comprised of a modified vaccinia virus Ankara (MVA) strain encoding human mucin 1 (MUC1) and interleukin-2 (IL-2) with potential immunostimulating and antineoplastic activities. Originally developed for the eradication of smallpox, MVA is a highly attenuated and replication-defective strain incapable of virion assembly and exerts potent immunostimulatory...
Investigational
Matched Description: … 1 (MUC1) and interleukin-2 (IL-2) with potential immunostimulating and antineoplastic activities. ... A bivalent cancer vaccine comprised of a modified vaccinia virus Ankara (MVA) strain encoding human mucin ... T lymphocyte (CTL) responses against tumor cells expressing MUC1, a tumor associated antigen, resulting …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
VB10.16
VB10.16 is a novel therapeutic antigen-presenting cell-targeting DNA vaccine developed to treat HPV16-positive cancers. It is composed of three parts, one encodes the E6/E7 fusion protein of human papillomavirus (HPV) type 16 (HPV16), a dimerization entity, and the part encoding a protein that specifically binds to antigen-presenting cells (APCs).
Investigational
Matched Description: … 16 (HPV16), a dimerization entity, and the part encoding a protein that specifically binds to antigen-presenting ... It is composed of three parts, one encodes the E6/E7 fusion protein of human papillomavirus (HPV) type ... VB10.16 is a novel therapeutic antigen-presenting cell-targeting DNA vaccine developed to treat HPV16 …
KITE-585
KITE-585 is an autologous, fully-human anti-B cell maturation antigen (BCMA) chimeric antigen receptor (CAR) T cell therapy. It is being investigated in the treatment of multiple myeloma.
Investigational
Matched Description: … KITE-585 is an autologous, fully-human anti-B cell maturation antigen (BCMA) chimeric antigen receptor …
Amolimogene
Amolimogene is an investigational therapeutic designed to specifically augment the body's defensive response to human papillomavirus (HPV). Amolimogene was biologically engineered as a targeted therapy for the treatment of cervical dysplasia.
Investigational
Matched Description: … is an investigational therapeutic designed to specifically augment the body's defensive response to human ... Amolimogene was biologically engineered as a targeted therapy for the treatment of cervical dysplasia …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Coltuximab ravtansine
Coltuximab ravtansine (SAR3419) targets CD19 and is being investigated for the treatment of acute lymphoblastic leukemia (ALL).
Investigational
Matched Description: … Coltuximab ravtansine (SAR3419) targets CD19 and is being investigated for the treatment of acute lymphoblastic …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Cytochrome P-450 CYP3A Inhibitors ... Cytochrome P-450 CYP3A4 Inhibitors ... Cytochrome P-450 Enzyme Inhibitors ... Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Cytochrome P-450 CYP3A Inhibitors ... Cytochrome P-450 CYP3A4 Inhibitors ... Cytochrome P-450 Enzyme Inhibitors ... Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) …
Indium In-111 satumomab pendetide
Tumor associated glycoprotein (TAG) 72 (B72.3) monoclonal antibody conjugated with Indium 111 for radioimaging colon tumors. Satumomab Pendetide (trade name: OncoScint®) is no longer commercially available.
Experimental
Withdrawn
Matched Categories: … Amino Acids, Peptides, and Proteins …
99mTc-14 F7 Mab
99mTc 14F7 Mab has strong anti tumor activity against myeloma cells in vivo. Growth inhibition and prolonged survival of the myeloma tumor were obtained as evidences of anti tumor effect after treatment with 99mTc 14F7 Mab.
Investigational
Matched Description: … Growth inhibition and prolonged survival of the myeloma tumor were obtained as evidences of anti tumor …
KB001
KB001 is a Humaneered™ PEGylated monoclonal antibody fragment for the treatment of life-threatening Pseudomonas aeruginosa infections, a common problem of cystic fibrosis and mechanically ventilated patients.
Investigational
Matched Description: … Pseudomonas aeruginosa infections, a common problem of cystic fibrosis and mechanically ventilated patients ... KB001 is a Humaneered™ PEGylated monoclonal antibody fragment for the treatment of life-threatening …
AVR118
AVR118 represents a new type of biopolymer chemistry that also possesses novel immunomodulator activity. This non-toxic peptide-nucleic acid, which to date has shown no indication of human toxicity, appears to stimulate the proinflammatory responses required to combat viral infections such as AIDS and human papilloma virus and to dampen aberrant...
Investigational
Matched Description: … AVR118 represents a new type of biopolymer chemistry that also possesses novel immunomodulator activity ... papilloma virus and to dampen aberrant autoimmune-type inflammatory responses. ... to stimulate the proinflammatory responses required to combat viral infections such as AIDS and human …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Odronextamab
Odronextamab is a hinge-stabilized, fully human immunoglobulin G4 (IgG4)-based CD20×CD3 bispecific antibody currently evaluated for the treatment of relapsed/refractory (R/R) B-Cell non-Hodgkin lymphoma (NHL).[A254187,A254197] Preliminary studies have shown that in patients with R/R NHL, the use of odronextamab does not lead to the development of neurologic toxicity; however, it can...
Investigational
Matched Description: … Odronextamab is a hinge-stabilized, fully human immunoglobulin G4 (IgG4)-based CD20×CD3 bispecific antibody ... [A254187] In December 2020, the FDA placed a partial clinical hold and requested the drug developer, ... with B-cell non-Hodgkin lymphoma, odronextamab elicited a durable response with a manageable safety …
Virus Specific T-Cell
Virus Specific T-Cells (VSTs) are a target therapy that are generated for specific viral antigens. These products are generated from virus-naive or virus-experienced autologous or allogenic sources. Antigens identified as an immune target are presented by antigen-presenting cells (APCs) to T-cells along with other molecules that stimulate their growth and...
Investigational
Matched Description: … These T-cells are then isolated from the donor and expanded in a culture to generate more VSTs. ... Antigens identified as an immune target are presented by antigen-presenting cells (APCs) to T-cells along ... with other molecules that stimulate their growth and activation. …
ADU-S100
ADU-S100 (MIW815) is a synthetic cyclic dinucleotide (CDN) agonist (activator) of Stimulator of Interferon Genes (STING), a receptor crucial to activate the innate (endogenous) immune system. ADU-S100 (MIW815) activates all known human and mouse STINGs, and effectively induces the expression of cytokines and chemokines, leading to a robust and durable...
Investigational
Matched Iupac: … (1R,3R,6R,8R,9R,10S,12R,15R,17R,18R)-8,17-bis(6-amino-9H-purin-9-yl)-9,18-dihydroxy-3,12-disulfanyl-2,4,7,11,13,16 …
Matched Description: … of cytokines and chemokines, leading to a robust and durable antigen-specific T-cell mediated immune ... ADU-S100 (MIW815) activates all known human and mouse STINGs, and effectively induces the expression ... Genes (STING), a receptor crucial to activate the innate (endogenous) immune system. …
Matched Salts cas: … 1638750-95-4 …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Matched Description: … of cytokines and chemokines, leading to a robust and durable antigen-specific T-cell mediated immune ... ADU-S100 (MIW815) activates all known human and mouse STINGs, and effectively induces the expression ... Genes (STING), a receptor crucial to activate the innate (endogenous) immune system. …
Matched Salts cas: … 1638750-95-4 …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Displaying drugs 151 - 175 of 192 in total