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Displaying drugs 1901 - 1925 of 1931 in total

Alkaline Phosphatase

Alkaline Phosphatase (AP) is an oral treatment and has a very favorable side-effect profile. AP only acts locally in the colon to reduce the continuous inflammation of the colon by endotoxin from Gram-negative bacteria and extracellular ATP in UC patients.
Investigational
Matched Description: … Alkaline Phosphatase (AP) is an oral treatment and has a very favorable side-effect profile. ... the colon to reduce the continuous inflammation of the colon by endotoxin from Gram-negative bacteria and …
Matched Categories: … Enzymes and Coenzymes …

ATX-101

ATX-101 (medical), sodium deoxycholate for subcutaneous injection, is being evaluated as a treatment for the reduction of localized fat deposits. This includes treatment of superficial lipomas (benign tumors of soft tissue composed of mature fat cells), fat deposits in the submental region of the face/neck, and localized fat deposits in...
Investigational
Matched Description: … of soft tissue composed of mature fat cells), fat deposits in the submental region of the face/neck, and ... As a naturally occurring component of the human body, deoxycholate is considered a ‘biocompatible’ detergent …

Sugemalimab

Sugemalimab is a fully human, full-length IgG4 monoclonal anti-PD-L1 antibody discovered by CStone Pharmaceuticals and being investigated against relapsed or refractory extranodal natural killer (NK)/T-cell lymphoma (R/R ENKTL) in adult patients and T-cell lymphoma.[L32868, L32873] It has been granted the Breakthrough Therapy Designation by the FDA to treat R/R ENKTL...
Investigational
Matched Description: … Sugemalimab is a fully human, full-length IgG4 monoclonal anti-PD-L1 antibody discovered by CStone Pharmaceuticals ... (R/R ENKTL) in adult patients and T-cell lymphoma. ... and being investigated against relapsed or refractory extranodal natural killer (NK)/T-cell lymphoma …
Matched Categories: … Amino Acids, Peptides, and Proteins …

AV608

AV608 is a NK-1 antagonist. It is developed for the treatment of Social anxiety disorder (SAD), irritable bowel syndrome (IBS) and overactive bladder (OAB).
Investigational
Matched Description: … It is developed for the treatment of Social anxiety disorder (SAD), irritable bowel syndrome (IBS) and …

Etizolam

Etizolam is a thienodiazepine which is chemically related to benzodiazepine (BDZ) drug class; it differs from BDZs in having a benzene ring replaced with a thiophene ring. It is an agonist at GABA-A receptors and possesses amnesic, anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. Initially introduced in 1983...
Experimental
Matched Description: … and skeletal muscle relaxant properties. ... disorders, etizolam is marketed in Japan, Italy and India. ... It is not approved for use by FDA in the US; however it remains unscheduled in several states and is …
Matched Categories: … Hypnotics and Sedatives ... Benzodiazepine hypnotics and sedatives ... Benzodiazepines and benzodiazepine derivatives …

NUC B1000

NUC B1000 is an expressed interfering RNA (eiRNA)- based product consisting of a plasmid DNA construct designed to produce four short interfering RNA (siRNA) molecules, formulated with a proprietary cationic-lipid delivery system. eiRNA is an approach to RNAi therapeutics, whereby a plasmid DNA coding for desired dsRNA is delivered to...
Investigational
Matched Description: … On January 11, 2008, it was announced that NUC B1000 was entering a phase 1 human safety study of its …

Nabiximols

Nabiximols (tradename Sativex®) is a whole plant extract from the Cannabis species Cannabis sativa L. that has been purified into the active components CBD (cannabidiol) and THC (delta-9-tetrahydrocannabinol). For trademark purposes, purified CBD is branded as Nabidiolex®, while THC is purified as the product Tetrabinex®. Sativex® is available in a...
Investigational
Matched Description: … resin of the marijuana plant, both of which interact with the cannabinoid receptors found in the human ... shown to act as a negative allosteric modulator of the cannabinoid CB1 receptor, the most abundant G-Protein ... , and physiological effects. …
Matched Categories: … Cannabinoids and similars …

Seletracetam

Seletracetam is a pyrrolidone derivative and with a structural similarity to newer generation antiepileptic drug levetiracetam. It binds to the same target as levetiracetam but with higher affinity and has shown potent seizure suppression in models of acquired and genetic epilepsy with high CNS tolerability. It is predicted to have...
Investigational
Matched Description: … It is predicted to have low drug-drug interactions and inhibition or induction of any major human metabolizing ... Food and Drug Administration (FDA) investigated as treatment of epilepsy and partial epilepsy however ... in models of acquired and genetic epilepsy with high CNS tolerability. …

Bardoxolone

Bardoxolone has been used in trials studying the treatment of LYMPHOMA and Solid Tumors. It is a synthetic triterpenoid and a highly potent activator of redox-sensitive signaling pathways that induce programmed cell death (apoptosis) in cancer cells that are under high levels of intrinsic oxidative stress. In contrast, Bardoxolone in...
Investigational
Matched Description: … Bardoxolone has been used in trials studying the treatment of LYMPHOMA and Solid Tumors. ... It is a synthetic triterpenoid and a highly potent activator of redox-sensitive signaling pathways that …

Dexloxiglumide

Dexloxiglumide is a selective cholecystokinin type A (CCKA) receptor antagonist in phase III testing by Rottapharm in Europe only, as U.S. trials have been discontinued. As the D-isomer of loxiglumide, it retains all pharmacological properties of loxiglumide but is more potent.
Investigational

Lintuzumab satetraxetan AC-225

Lintuzumab actinium Ac-225 is under investigation in clinical trial NCT00672165 (Targeted Atomic Nano-Generators (Actinium-225-Labeled Humanized Anti-CD33 Monoclonal Antibody HuM195) in Patients With Advanced Myeloid Malignancies).
Investigational

TG4010

A bivalent cancer vaccine comprised of a modified vaccinia virus Ankara (MVA) strain encoding human mucin 1 (MUC1) and interleukin-2 (IL-2) with potential immunostimulating and antineoplastic activities. Originally developed for the eradication of smallpox, MVA is a highly attenuated and replication-defective strain incapable of virion assembly and exerts potent immunostimulatory...
Investigational
Matched Description: … A bivalent cancer vaccine comprised of a modified vaccinia virus Ankara (MVA) strain encoding human mucin ... 1 (MUC1) and interleukin-2 (IL-2) with potential immunostimulating and antineoplastic activities. ... strain incapable of virion assembly and exerts potent immunostimulatory activity against antigens. …
Matched Categories: … Amino Acids, Peptides, and Proteins …

SARS-CoV-2 mRNA vaccine

SARS-CoV-2 mRNA vaccine (ARCoV) is a novel mRNA coronavirus vaccine that consists of a lipid nanoparticle-encapsulated mRNA encoding the receptor binding domain of SARS-CoV-2 . It is the first COVID-19 mRNA vaccine to be approved for clinical trials in China, and was co-developed by Abogen Biosciences, Walvax Biotechnolgoy Co., Ltd....
Investigational
Matched Description: … Preclinical studies in mice and non-human primates has shown that intramuscular administration of ARCoV ... elicited a Th1-biased cellular response and robust antibodies against SARS-CoV-2[A220048]. ... by Abogen Biosciences, Walvax Biotechnolgoy Co., Ltd. and the People’s Liberation Army (PLA) Academy …

RG-7795

Investigational

Tirapazamine

Tirapazamine, also known as SR-4233, is an experimental anticancer drug that is activated in hypoxic conditions. This activation is very useful as this hypoxic state is found in human solid tumors in a common phenomenon known as tumor hypoxia. Hence, tirapazamine is solely activated in those hypoxic areas of solid...
Investigational
Matched Description: … This activation is very useful as this hypoxic state is found in human solid tumors in a common phenomenon ... Tirapazamine entered phase III testing in 2006 for patients with head and neck cancer and gynecological ... into consideration that normally, the cells in these hypoxic regions are resistant to radiotherapy and …

XAV-19

XAV-19 is an intravenous antibody-based treatment targeted towards SARS-CoV-2 and other coronaviruses[L16553,L16558]. The therapy concept is based on COVID-19 convalescent plasma. However, rather than using human plasma, XAV-19 is a heterologous swine glyco-humanized polyclonal antibody that targets the spike protein of SARS-CoV-2[L16553,L16558]. The therapy offers three beneficial effects: the ability...
Investigational
Matched Description: … However, rather than using human plasma, XAV-19 is a heterologous swine glyco-humanized polyclonal antibody ... XAV-19 is an intravenous antibody-based treatment targeted towards SARS-CoV-2 and other coronaviruses ... offers three beneficial effects: the ability to neutralize the virus, reduce inflammatory responses, and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Natural Killer Cell

Natural Killer (NK) cells originate and differentiate from hematopoietic stem cells through various signalling pathways involving cytokines and interleukins. These cells arise from CD34+ lymphoid progenitors and comprise 10-15% of all lymphocytes in human peripheral blood. Once completely differentiated, NK cells lack B (CD19-) and T(CD3-) lymphocyte markers and carry...
Investigational
Matched Description: … These cells arise from CD34+ lymphoid progenitors and comprise 10-15% of all lymphocytes in human peripheral ... Induced pluripotent stem cells (iPSCs) and human embryonic stem cells (HESCs) are also used to generate ... Once completely differentiated, NK cells lack B (CD19-) and T(CD3-) lymphocyte markers and carry their …

Abivertinib

Abivertinib is a tyrosine kinase inhibitor targeted against mutant forms of both human epidermal growth factor receptor (EGFR) and Bruton's tyrosine kinase (BTK). It has been investigated for use in the treatment of non-small cell lung cancer (NSCLC) and B-cell malignancies. In binding to and inhibiting EGFR and BTK receptors,...
Investigational
Matched Description: … Abivertinib is a tyrosine kinase inhibitor targeted against mutant forms of both human epidermal growth ... In binding to and inhibiting EGFR and BTK receptors, abivertinib exerts immunomodulatory effects by preventing ... factor receptor (EGFR) and Bruton's tyrosine kinase (BTK). …

COVID19 s-vax loaded autologous dendritic cell vaccine

Dendritic cells (DCs) can be derived and differentiated from peripheral blood mononuclear cells in the presence of specific cytokines and growth factors. These cells are then loaded with antigens produced by a virus or tumor cell and administered as a vaccine. Dendritic Cells (DCs) are showing potential as natural adjuvants...
Investigational
Matched Description: … As of May 2020, the company is pursuing a human clinical trial (ChiCTR2000033003) to test the safety ... and immunogenicity of the vaccine. ... presence of specific cytokines and growth factors. …

Phosphatidyl serine

Phosphatidyl serine (PS) is a phospholipid nutrient found in fish, green leafy vegetables, soybeans and rice, and is essential for the normal functioning of neuronal cell membranes and activates Protein kinase C (PKC) which has been shown to be involved in memory function. In apoptosis, phosphatidyl serine is transferred to...
Investigational
Nutraceutical
Matched Description: … rice, and is essential for the normal functioning of neuronal cell membranes and activates Protein kinase ... Phosphatidyl serine (PS) is a phospholipid nutrient found in fish, green leafy vegetables, soybeans and ... PS has been investigated in a small number of double-blind placebo trials and has been shown to increase …

Xylazine

Xylazine is a clonidine analog used as a non-opioid tranquilizer in veterinary medicine and as an emetic, especially in cats.[A9095,L42675,A251420] It acts as an agonist at α2 adrenoceptors; however, its affinity is lower than the one reported for other α2 adrenergic receptor agonists such as detomidine and medetomidine. Xylazine is...
Vet approved
Matched Description: … [A32545] Xylazine is not approved for human use and requires a veterinary licence for its purchase and ... [L42675] Xylazine is sometimes used as an adulterant and combined with opioids and recreational drugs ... [A9096] The use of xylazine can lead to hypotension and bradycardia[A9092,A9093], and when combined with …
Matched Categories: … Hypnotics and Sedatives …

CTA018

CTA018 is a member of a new class of vitamin D analogues with a dual mechanism of action, called Vitamin D Signal Amplifiers. This proprietary new drug is both a potent inhibitor of CYP24 (the enzyme responsible for the breakdown of vitamin D) and a potent activator of vitamin D...
Investigational
Matched Description: … Preclinical studies have shown that CTA018 inhibits the proliferation of rapidly dividing cells such as human ... calcipotriol and it is expected to have a greater safety index. ... new drug is both a potent inhibitor of CYP24 (the enzyme responsible for the breakdown of vitamin D) and …

Omega-6 fatty acids

Omega-6 fatty acids are polyunsaturated fatty acids with a final carbon-carbon double bond in the n-6 position, that is, the sixth bond, counting from the methyl end. They are a family of fatty acid molecules that act as precursors to potent lipid mediator signalling molecules with either pro-inflammatory and anti-inflammatory...
Nutraceutical
Matched Description: … molecules that act as precursors to potent lipid mediator signalling molecules with either pro-inflammatory and …

Bavituximab

Bavituximab is a chimeric Anti-PS monoclonal antibody analog which is used to potentially treat cancers and viral infections. It binds to phosphatidylserine and other exposed host cell lipids when induced by cellular stress. Additional analogs in the class include 3G4, 2aG4, 9d2 and Hu3g4.
Investigational
Matched Description: … Additional analogs in the class include 3G4, 2aG4, 9d2 and Hu3g4. ... It binds to phosphatidylserine and other exposed host cell lipids when induced by cellular stress. ... Bavituximab is a chimeric Anti-PS monoclonal antibody analog which is used to potentially treat cancers and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Droloxifene

Droloxifene, a derivative of the triphenylethylene drug tamoxifen, is a novel selective estrogen receptor modulator (SERM). Droloxifene also exhibits more rapid pharmacokinetics, reaching peak concentrations and being eliminated much more rapidly than tamoxifen. Its higher affinity to the estrogen receptor, higher anti-estrogenic to estrogenic ratio, more effective inhibition of cell...
Investigational
Matched Description: … over tamoxifen in the treatment of human breast cancer. ... Droloxifene appears active and tolerable. ... Droloxifene may have an effect on bone and breast tissue because it induces apoptosis. …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Displaying drugs 1901 - 1925 of 1931 in total