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Displaying drugs 626 - 650 of 709 in total
TAS-106
TAS-106 is a new nucleoside antimetabolite. TAS-106 has demonstrated strong antitumor activity without serious toxicity in nude rat models bearing human tumours .
Investigational
Matched Synonyms: … 4-Amino-1-((2R,3R,4R,5R)-4-ethynyl-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)pyrimidin-2-one …
Matched Iupac: … 4-amino-1-[(2R,3R,4S,5R)-4-ethynyl-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2 …
Matched Description: … -106 has demonstrated strong antitumor activity without serious toxicity in nude rat models bearing human …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Nucleic Acids, Nucleotides, and Nucleosides …
Matched Iupac: … 4-amino-1-[(2R,3R,4S,5R)-4-ethynyl-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2 …
Matched Description: … -106 has demonstrated strong antitumor activity without serious toxicity in nude rat models bearing human …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Nucleic Acids, Nucleotides, and Nucleosides …
Bebtelovimab
Bebtelovimab (LY-COV1404, LY-3853113) is a human monoclonal antibody approved for emergency use in the treatment of COVID-19. It binds to a portion of the SARS-CoV-2 spike (S) protein's receptor-binding domain, thereby preventing spike protein interaction with ACE2 and subsequent viral entry into host cells. Bebtelovimab is notable in that the...
Investigational
Withdrawn
Matched Description: … (Delta) and B.1.1.529 (Omicron) variants. ... Bebtelovimab (LY-COV1404, LY-3853113) is a human monoclonal antibody approved for emergency use in the ... viable candidate for use in resistant SARS-CoV-2 strains (i.e. variants of concern, VOCs), including the B.1.617.2 …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
ZM-39923
ZM-39923 is a small molecule that inhibits Janus kinase and human tissue transglutaminase (TGM2).
Investigational
Matched Synonyms: … 1-propanone, 3-((1-methylethyl)(phenylmethyl)amino)-1-(2-naphthalenyl)- ... 3-((1-methylethyl)(phenylmethyl)amino)-1-(2-naphthalenyl)-1-propanone ... 3-(benzyl(propan-2-yl)amino)-1-(naphthalen-2-yl)propan-1-one …
Matched Iupac: … 3-[benzyl(propan-2-yl)amino]-1-(naphthalen-2-yl)propan-1-one …
Matched Description: … ZM-39923 is a small molecule that inhibits Janus kinase and human tissue transglutaminase (TGM2). …
Matched Iupac: … 3-[benzyl(propan-2-yl)amino]-1-(naphthalen-2-yl)propan-1-one …
Matched Description: … ZM-39923 is a small molecule that inhibits Janus kinase and human tissue transglutaminase (TGM2). …
IRX-2
IRX-2 contains a human leukocyte-derived cytokine mixture. It is being investigated to promote or enhance an anti-cancer immune response.
Investigational
Matched Description: … IRX-2 contains a human leukocyte-derived cytokine mixture. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Intercellular Signaling Peptides and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Intercellular Signaling Peptides and Proteins …
Rifalazil
Rifalazil is a derivative of the antibiotic rifamycin. It is being investigated by ActivBiotics for the treatment of various bacterial infections.
Investigational
Matched Synonyms: … 3'-hydroxy-5'-(4-isobutyl-1-piperazinyl)benzoxazinorifamycin …
Matched Iupac: … ,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,32-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-30-[4- ... (2-methylpropyl)piperazin-1-yl]-6,23,37-trioxo-8,27,38-trioxa-24,34-diazahexacyclo[23.11.1.1^{4,7}.0^ …
Matched Categories: … Heterocyclic Compounds with 4 or More Rings …
Matched Iupac: … ,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,32-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-30-[4- ... (2-methylpropyl)piperazin-1-yl]-6,23,37-trioxo-8,27,38-trioxa-24,34-diazahexacyclo[23.11.1.1^{4,7}.0^ …
Matched Categories: … Heterocyclic Compounds with 4 or More Rings …
MVA-BN-brachyury-TRICOM vaccine
MVA-BN-brachyury-TRICOM vaccine is an investigational cancer vaccine. It is composed of recombinant vaccinia viral vector, modified vaccinia Ankara-Bavarian Nordic (MVA-BN), encoding the human transcription factor and tumour-associated antigen (TAA) brachyury, and a triad of T-cell co-stimulatory molecules (TRICOM), which is comprised of the three human immune-enhancing co-stimulatory molecules B7-1, ICAM-1...
Investigational
Matched Description: … B7-1, ICAM-1 and LFA-3. ... transcription factor and tumour-associated antigen (TAA) brachyury, and a triad of T-cell co-stimulatory ... recombinant vaccinia viral vector, modified vaccinia Ankara-Bavarian Nordic (MVA-BN), encoding the human …
Quercetin
Quercetin is a flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds. Glycosylated forms include RUTIN and quercetrin.
Experimental
Investigational
Matched Synonyms: … 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one ... 3,3',4',5,7-pentahydroxyflavone ... 3,5,7,3',4'-Pentahydroxyflavone …
Matched Iupac: … 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one …
Matched Description: … Glycosylated forms include RUTIN and quercetrin. …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Iupac: … 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one …
Matched Description: … Glycosylated forms include RUTIN and quercetrin. …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Seletracetam
Seletracetam is a pyrrolidone derivative and with a structural similarity to newer generation antiepileptic drug levetiracetam. It binds to the same target as levetiracetam but with higher affinity and has shown potent seizure suppression in models of acquired and genetic epilepsy with high CNS tolerability. It is predicted to have...
Investigational
Matched Synonyms: … (2S)-2-((4S)-4-(2,2-Difluoroethenyl)-2-oxopyrrolidin-1-yl)butanamide …
Matched Iupac: … (2S)-2-[(4S)-4-(2,2-difluoroethenyl)-2-oxopyrrolidin-1-yl]butanamide …
Matched Description: … It is predicted to have low drug-drug interactions and inhibition or induction of any major human metabolizing ... Food and Drug Administration (FDA) investigated as treatment of epilepsy and partial epilepsy however ... in models of acquired and genetic epilepsy with high CNS tolerability. …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Iupac: … (2S)-2-[(4S)-4-(2,2-difluoroethenyl)-2-oxopyrrolidin-1-yl]butanamide …
Matched Description: … It is predicted to have low drug-drug interactions and inhibition or induction of any major human metabolizing ... Food and Drug Administration (FDA) investigated as treatment of epilepsy and partial epilepsy however ... in models of acquired and genetic epilepsy with high CNS tolerability. …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Peldesine
Peldesine is a potent inhibitor of human CCRF-CEM T-cell proliferation. It has undergone phase I trials for the treatment of Human Immunodeficiency Virus (HIV) infections.
Investigational
Matched Synonyms: … 2-Amino-3,5-dihydro-7-(3-pyridylmethyl)-4H-pyrrolo(3,2-d)pyrimidin-4-one …
Matched Iupac: … 2-amino-7-[(pyridin-3-yl)methyl]-1H,4H,5H-pyrrolo[3,2-d]pyrimidin-4-one …
Matched Description: … Peldesine is a potent inhibitor of human CCRF-CEM T-cell proliferation. ... It has undergone phase I trials for the treatment of Human Immunodeficiency Virus (HIV) infections. …
Matched Iupac: … 2-amino-7-[(pyridin-3-yl)methyl]-1H,4H,5H-pyrrolo[3,2-d]pyrimidin-4-one …
Matched Description: … Peldesine is a potent inhibitor of human CCRF-CEM T-cell proliferation. ... It has undergone phase I trials for the treatment of Human Immunodeficiency Virus (HIV) infections. …
IMGN632
Investigational
Coagulin-B
Coagulin-B is an adeno-associated viral vector expressing human blood-coagulation Factor IX.[A259038, A259043] It was previously investigated for the treatment of hemophilia; however, the manufacturing company discontinued the Phase I trial in 2004, halting its further development and investigation.
Investigational
Matched Synonyms: … Coagulin B …
Matched Name: … Coagulin-B …
Matched Description: … Coagulin-B is an adeno-associated viral vector expressing human blood-coagulation Factor IX. ... , the manufacturing company discontinued the Phase I trial in 2004, halting its further development and …
Matched Name: … Coagulin-B …
Matched Description: … Coagulin-B is an adeno-associated viral vector expressing human blood-coagulation Factor IX. ... , the manufacturing company discontinued the Phase I trial in 2004, halting its further development and …
BBM-H803
BBM-H803 is a recombinant adeno-associated virus (AAV) based gene therapy drug for hemophilia A developed and manufactured by Belief BioMed. It consists of an adeno-associated virus vector containing an expression cassette of the human Factor VIII transgene.
Investigational
Matched Description: … It consists of an adeno-associated virus vector containing an expression cassette of the human Factor ... BBM-H803 is a recombinant adeno-associated virus (AAV) based gene therapy drug for hemophilia A developed and …
Albinterferon Alfa-2B
Albumin-interferon alpha (Albuferon) is a novel, long-acting form of interferon alpha. Recombinant interferon alpha is approved for the treatment of hepatitis C, hepatitis B, and a broad range of cancers. Human Genome Sciences modified interferon alpha to improve its pharmacological properties by using the company's proprietary albumin fusion technology. Human...
Investigational
Matched Description: … Recombinant interferon alpha is approved for the treatment of hepatitis C, hepatitis B, and a broad range ... In response to an FDA ruling, Novartis and Human Genome Sciences announced on October 5, 2010 that they ... Human Genome Sciences is developing Albuferon as a potential treatment for chronic hepatitis C. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Intercellular Signaling Peptides and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Intercellular Signaling Peptides and Proteins …
Icaridin
Icaridin, also known as Picaridin or hydroxy-ethyl isobutyl piperidine carboxylate, is a cyclic amine and a member of the piperidine chemical family. Piperidines are structural components of piperine, which is a plant extract from the genus _Piper _, or pepper. Icaridin has been commonly used as a topically-applied insect repellent...
Experimental
Matched Iupac: … butan-2-yl 2-(2-hydroxyethyl)piperidine-1-carboxylate …
Matched Description: … Icaridin, also known as Picaridin or hydroxy-ethyl isobutyl piperidine carboxylate, is a cyclic amine and ... repellent by the Public Health Agency of Canada’s Canadian Advisory Committee on Tropical Medicine and ... insect repellent in various countries but was officially licensed for use in the United States in 2001 and …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Description: … Icaridin, also known as Picaridin or hydroxy-ethyl isobutyl piperidine carboxylate, is a cyclic amine and ... repellent by the Public Health Agency of Canada’s Canadian Advisory Committee on Tropical Medicine and ... insect repellent in various countries but was officially licensed for use in the United States in 2001 and …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
CTx-PDE6b
CTx-PDE6b is an adeno-associated virus (AAV) based gene therapy designed to deliver a full-length non-mutated copy of the functional human PDE6b gene. Being commercialied by Coave Therapeutics, it is being investigated for the treatment of retinitis pigmentosa due to PDE6b gene mutations.
Investigational
Matched Description: … virus (AAV) based gene therapy designed to deliver a full-length non-mutated copy of the functional human …
MRx-4DP0004
MRx-4DP0004 is a lyophilised formulation of the Bifidobacterium breve strain of commensal bacteria. It is a live biotherapeutic derived from the microbiota of a healthy human infant.
Investigational
Matched Description: … It is a live biotherapeutic derived from the microbiota of a healthy human infant. …
Tarenflurbil
Tarenflurbil is an investigational drug that was studied in patients with mild Alzheimer's disease. It is a selective amyloid lowering agent (SALA) that reduces levels of the toxic peptide amyloid beta 42 (Aβ42) in cultured human cells and in animal models. Aβ42 is the primary initiator of neurotoxicity and amyloid...
Investigational
Matched Synonyms: … (2R)-2-(2-fluorobiphenyl-4-yl)propanoic acid ... (−)-(2R)-2-(2-fluorobiphenyl-4-yl)propanoic acid ... (R)-2-fluoro-α-methyl(1,1'-biphenyl)-4-acetic acid …
Matched Iupac: … (2R)-2-{2-fluoro-[1,1'-biphenyl]-4-yl}propanoic acid …
Matched Description: … cells and in animal models. ... amyloid lowering agent (SALA) that reduces levels of the toxic peptide amyloid beta 42 (Aβ42) in cultured human ... Aβ42 is the primary initiator of neurotoxicity and amyloid plaque development in the brains of Alzheimer's …
Matched Categories: … Gamma Secretase Inhibitors and Modulators …
Matched Iupac: … (2R)-2-{2-fluoro-[1,1'-biphenyl]-4-yl}propanoic acid …
Matched Description: … cells and in animal models. ... amyloid lowering agent (SALA) that reduces levels of the toxic peptide amyloid beta 42 (Aβ42) in cultured human ... Aβ42 is the primary initiator of neurotoxicity and amyloid plaque development in the brains of Alzheimer's …
Matched Categories: … Gamma Secretase Inhibitors and Modulators …
Genistein
An isoflavonoid derived from soy products. It inhibits protein-tyrosine kinase and topoisomerase-II (DNA topoisomerases, type II) activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 phase arrest in human and murine cell lines.
Additionally, genistein has antihelmintic activity. It has been...
Investigational
Matched Synonyms: … 4H-1-BENZOPYRAN-4-ONE, 5,7-DIHYDROXY-3-(4-HYDROXYPHENYL)- ... 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one ... 5,7-dihydroxy-3-(4-hydroxyphenyl)-chromen-4-one …
Matched Iupac: … 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one …
Matched Description: … Experimentally, it has been shown to induce G2 phase arrest in human and murine cell lines. ... It inhibits protein-tyrosine kinase and topoisomerase-II (DNA topoisomerases, type II) activity and is ... used as an antineoplastic and antitumor agent. …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Iupac: … 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one …
Matched Description: … Experimentally, it has been shown to induce G2 phase arrest in human and murine cell lines. ... It inhibits protein-tyrosine kinase and topoisomerase-II (DNA topoisomerases, type II) activity and is ... used as an antineoplastic and antitumor agent. …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Hormones, Hormone Substitutes, and Hormone Antagonists …
BBIBP-CorV
BBIBP-CorV vaccine contains a SARS-CoV-2 strain inactivated inside Vero Cells. Investigation shows this vaccine induces neutralizing antibodies in several mammalian species while also showing protective efficacy with SARS-CoV-2 challenge in rhesus macaques . As of August 2020, this vaccine is being tested for prophylaxis against COVID-19 in human clinical trials.
Investigational
Matched Description: … As of August 2020, this vaccine is being tested for prophylaxis against COVID-19 in human clinical trials …
Nafamostat
Nafamostat is a synthetic serine protease inhibitor that is commonly formulated with hydrochloric acid due to its basic properties. It has been used in trials studying the prevention of Liver Transplantation and Postreperfusion Syndrome. The use of nafamostat in Asian countries is approved as an anticoagulant therapy for patients undergoing...
Investigational
Matched Iupac: … 6-carbamimidoylnaphthalen-2-yl 4-carbamimidamidobenzoate …
Matched Description: … It has been used in trials studying the prevention of Liver Transplantation and Postreperfusion Syndrome …
Matched Salts cas: … 82956-11-4 …
Matched Description: … It has been used in trials studying the prevention of Liver Transplantation and Postreperfusion Syndrome …
Matched Salts cas: … 82956-11-4 …
Entinostat
Entinostat is under investigation for the treatment and other of Volunteers, Breast Cancer, Human Volunteers, and Normal Volunteers. Entinostat has been investigated for the treatment of Non-Small Lung Cancer, Epigenetic Therapy.
Investigational
Matched Synonyms: … N-(2-aminophenyl)-4-(N-(pyridin-3-ylmethoxycarbonyl)aminomethyl)benzamide ... N-[[4-[(2-aminoanilino)-oxomethyl]phenyl]methyl]carbamic acid 3-pyridinylmethyl ester …
Matched Iupac: … (pyridin-3-yl)methyl N-({4-[(2-aminophenyl)carbamoyl]phenyl}methyl)carbamate …
Matched Description: … Entinostat is under investigation for the treatment and other of Volunteers, Breast Cancer, Human Volunteers ... , and Normal Volunteers. …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Antineoplastic and Immunomodulating Agents …
Matched Iupac: … (pyridin-3-yl)methyl N-({4-[(2-aminophenyl)carbamoyl]phenyl}methyl)carbamate …
Matched Description: … Entinostat is under investigation for the treatment and other of Volunteers, Breast Cancer, Human Volunteers ... , and Normal Volunteers. …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Antineoplastic and Immunomodulating Agents …
Inodiftagene vixteplasmid
Inodiftagene vixteplasmid is a plasmid DNA vector encoding the diphtheria toxin A (dT-a) gene under transcriptional regulation of the promoter region of the human H19 gene (an imprinted maternally expressed non-protein coding gene).
Investigational
Matched Description: … encoding the diphtheria toxin A (dT-a) gene under transcriptional regulation of the promoter region of the human …
Captodiame
Captodiame, also known as captodiamine, is an antihistamine which is used as a sedative and anxiolytic. It is a derivative of diphenhydramine. Captodiame has been suggested for use in preventing benzodiazepine withdrawal syndrome.
Experimental
Matched Synonyms: … 2-[(4-butylsulfanylphenyl)-phenyl-methyl]sulfanyl-N,N-dimethylethanamine …
Matched Iupac: … [2-({[4-(butylsulfanyl)phenyl](phenyl)methyl}sulfanyl)ethyl]dimethylamine …
Matched Description: … Captodiame, also known as captodiamine, is an antihistamine which is used as a sedative and anxiolytic …
Matched Salts cas: … 904-04-1 …
Matched Iupac: … [2-({[4-(butylsulfanyl)phenyl](phenyl)methyl}sulfanyl)ethyl]dimethylamine …
Matched Description: … Captodiame, also known as captodiamine, is an antihistamine which is used as a sedative and anxiolytic …
Matched Salts cas: … 904-04-1 …
Cimlanod
Cimlanod is under investigation in clinical trial NCT02819271 (A First-in-Human Study of the Safety of Single Continuous Intravenous (IV) Infusions of CXL-1427 for up to 48 Hours in Healthy Volunteers).
Investigational
Matched Description: … Cimlanod is under investigation in clinical trial NCT02819271 (A First-in-Human Study of the Safety of …
Displaying drugs 626 - 650 of 709 in total