The pharmacogenetics of methotrexate.
Article Details
- CitationCopy to clipboard
Hider SL, Bruce IN, Thomson W
The pharmacogenetics of methotrexate.
Rheumatology (Oxford). 2007 Oct;46(10):1520-4. Epub 2007 Jun 24.
- PubMed ID
- 17586865 [ View in PubMed]
- Abstract
Methotrexate (MTX) is a cornerstone of therapy for rheumatoid arthritis. However, it is not universally effective and up to one-third of patients fail to respond to treatment, either because of inefficacy or adverse events, although at present it is not possible to predict therapy response accurately. Pharmacogenetics is the study of variability in drug response due to heredity. MTX has a complex intracellular metabolism and acts via a number of key enzymes. This review critically appraises the studies of MTX pharmacogenetics and highlights the need for further work in this area.
DrugBank Data that Cites this Article
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Methotrexate Bifunctional purine biosynthesis protein PURH Protein Humans UnknownInhibitorDetails Methotrexate Dihydrofolate reductase Protein Humans UnknownSubstrateDetails Methotrexate Folylpolyglutamate synthase, mitochondrial Protein Humans UnknownSubstrateDetails Methotrexate Gamma-glutamyl hydrolase Protein Humans UnknownSubstrateDetails Methotrexate Methylenetetrahydrofolate reductase Protein Humans UnknownSubstrateDetails Methotrexate Thymidylate synthase Protein Humans UnknownSubstrateDetails