Progestogens in menopausal hormone therapy.
Article Details
- CitationCopy to clipboard
Binkowska M, Woron J
Progestogens in menopausal hormone therapy.
Prz Menopauzalny. 2015 Jun;14(2):134-43. doi: 10.5114/pm.2015.52154. Epub 2015 Jun 22.
- PubMed ID
- 26327902 [ View in PubMed]
- Abstract
Progestogens share one common effect: the ability to convert proliferative endometrium to its secretory form. In contrast, their biological activity is varied, depending on the chemical structure, pharmacokinetics, receptor affinity and different potency of action. Progestogens are widely used in the treatment of menstrual cycle disturbances, various gynaecological conditions, contraception and menopausal hormone therapy. The administration of progestogen in menopausal hormone therapy is essential in women with an intact uterus to protect against endometrial hyperplasia and cancer. Progestogen selection should be based on the characteristics available for each progestogen type, relying on the assessment of relative potency of action in experimental models and animal models, and on the indirect knowledge brought by studies of the clinical use of different progestogen formulations. The choice of progestogen should involve the conscious use of knowledge of its benefits, with a focus on minimizing potential side effects. Unfortunately, there are no direct clinical studies comparing the metabolic effects of different progestogens.
DrugBank Data that Cites this Article
- Drugs
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Cyproterone acetate Cytochrome P450 3A4 Protein Humans NoSubstrateInhibitorDetails Dienogest Cytochrome P450 3A4 Protein Humans UnknownSubstrateDetails Medrogestone Cytochrome P450 3A4 Protein Humans NoSubstrateDetails Nomegestrol Cytochrome P450 3A4 Protein Humans NoSubstrateDetails Nomegestrol acetate Cytochrome P450 3A4 Protein Humans NoSubstrateDetails Promegestone Cytochrome P450 3A4 Protein Humans NoSubstrateDetails - Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareMedrogestoneButalbital The serum concentration of Medrogestone can be decreased when it is combined with Butalbital. MedrogestonePentobarbital The serum concentration of Medrogestone can be decreased when it is combined with Pentobarbital. MedrogestoneSecobarbital The serum concentration of Medrogestone can be decreased when it is combined with Secobarbital. MedrogestoneMethohexital The serum concentration of Medrogestone can be decreased when it is combined with Methohexital. MedrogestoneThiopental The serum concentration of Medrogestone can be decreased when it is combined with Thiopental.