Linking pharmacology to clinical reports: cyclobenzaprine and its possible association with serotonin syndrome.
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Mestres J, Seifert SA, Oprea TI
Linking pharmacology to clinical reports: cyclobenzaprine and its possible association with serotonin syndrome.
Clin Pharmacol Ther. 2011 Nov;90(5):662-5. doi: 10.1038/clpt.2011.177. Epub 2011 Oct 5.
- PubMed ID
- 21975349 [ View in PubMed]
- Abstract
The link between cyclobenzaprine (Flexeril) administration and serotonin syndrome (SS) is subject to debate. Establishing such a connection is difficult because of the limited number of case reports available and the almost complete ignorance of its preclinical pharmacology. In this context, evidence is provided here that cyclobenzaprine blocks the serotonin and norepinephrine transporters and binds to another set of five serotonin receptors. SS should be considered when indicative signs occur in the context of cyclobenzaprine use.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Cyclobenzaprine 5-hydroxytryptamine receptor 2A Protein Humans YesAntagonistDetails Cyclobenzaprine 5-hydroxytryptamine receptor 2B Protein Humans UnknownAntagonistDetails Cyclobenzaprine 5-hydroxytryptamine receptor 2C Protein Humans UnknownAntagonistDetails Cyclobenzaprine 5-hydroxytryptamine receptor 6 Protein Humans UnknownAntagonistDetails Cyclobenzaprine 5-hydroxytryptamine receptor 7 Protein Humans UnknownAntagonistDetails Cyclobenzaprine Sodium-dependent noradrenaline transporter Protein Humans UnknownInhibitorDetails Cyclobenzaprine Sodium-dependent serotonin transporter Protein Humans UnknownInhibitorDetails Cyclobenzaprine Toll-like receptor 4 Protein Humans UnknownInhibitorDetails - Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareIsocarboxazidCyclobenzaprine Cyclobenzaprine may increase the serotonergic activities of Isocarboxazid. LinezolidCyclobenzaprine Cyclobenzaprine may increase the serotonergic activities of Linezolid. MinaprineCyclobenzaprine Cyclobenzaprine may increase the serotonergic activities of Minaprine. MoclobemideCyclobenzaprine Cyclobenzaprine may increase the serotonergic activities of Moclobemide. NialamideCyclobenzaprine Cyclobenzaprine may increase the serotonergic activities of Nialamide.