Inhibitors of MAO-A and MAO-B in Psychiatry and Neurology.
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Finberg JP, Rabey JM
Inhibitors of MAO-A and MAO-B in Psychiatry and Neurology.
Front Pharmacol. 2016 Oct 18;7:340. doi: 10.3389/fphar.2016.00340. eCollection 2016.
- PubMed ID
- 27803666 [ View in PubMed]
- Abstract
Inhibitors of MAO-A and MAO-B are in clinical use for the treatment of psychiatric and neurological disorders respectively. Elucidation of the molecular structure of the active sites of the enzymes has enabled a precise determination of the way in which substrates and inhibitor molecules are metabolized, or inhibit metabolism of substrates, respectively. Despite the knowledge of the strong antidepressant efficacy of irreversible MAO inhibitors, their clinical use has been limited by their side effect of potentiation of the cardiovascular effects of dietary amines ("cheese effect"). A number of reversible MAO-A inhibitors which are devoid of cheese effect have been described in the literature, but only one, moclobemide, is currently in clinical use. The irreversible inhibitors of MAO-B, selegiline and rasagiline, are used clinically in treatment of Parkinson's disease, and a recently introduced reversible MAO-B inhibitor, safinamide, has also been found efficacious. Modification of the pharmacokinetic characteristics of selegiline by transdermal administration has led to the development of a new drug form for treatment of depression. The clinical potential of MAO inhibitors together with detailed knowledge of the enzyme's binding site structure should lead to future developments with these drugs.
DrugBank Data that Cites this Article
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions (R)-N-methyl-N-2-propynyl-1-indanamine Amine oxidase [flavin-containing] B Protein Humans UnknownNot Available Details - Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareAlmotriptanNicotine The metabolism of Almotriptan can be decreased when combined with Nicotine. AlmotriptanPhentermine The metabolism of Almotriptan can be decreased when combined with Phentermine. AlmotriptanPhenylpropanolamine The metabolism of Almotriptan can be decreased when combined with Phenylpropanolamine. AlmotriptanPropranolol The metabolism of Almotriptan can be decreased when combined with Propranolol. AlmotriptanPseudoephedrine The metabolism of Almotriptan can be decreased when combined with Pseudoephedrine.