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Identification
NamePseudoephedrine
Accession NumberDB00852  (APRD00634)
TypeSmall Molecule
GroupsApproved
DescriptionAn alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used in the treatment of several disorders including asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.
Structure
Thumb
Synonyms
(+) threo-2-(methylamino)-1-phenyl-1-propanol
(+)-(1S,2S)-Pseudoephedrine
(+)-Pseudoephedrine
(+)-psi-Ephedrine
(+)-threo-Ephedrine
d-Isoephedrine
d-Pseudoephedrine
d-psi-2-Methylamino-1-phenyl-1-propanol
d-psi-Ephedrine
Isoephedrine
L-(+)-Pseudoephedrine
L(+)-psi-Ephedrine
Pseudoefedrina
pseudoéphédrine
Pseudoephedrine D-form
Pseudoephedrinum
Psi-ephedrin
Psi-ephedrine
trans-Ephedrine
ψ-ephedrine
External IDs Not Available
Product Ingredients
IngredientUNIICASInChI KeyDetails
Pseudoephedrine hydrochloride6V9V2RYJ8N 345-78-8BALXUFOVQVENIU-KXNXZCPBSA-NDetails
Pseudoephedrine sulfateY9DL7QPE6B 7460-12-0XVPDSDYVNYOVMP-KXNXZCPBSA-NDetails
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
SudogestTablet, film coated60 mg/1Oralbryant ranch prepack1994-10-01Not applicableUs
Approved Generic Prescription ProductsNot Available
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
12 Hour DecongestantTablet, film coated, extended release120 mg/1OralL. Perrigo Company2011-10-04Not applicableUs
12 Hour DecongestantTablet, film coated, extended release120 mg/1OralMeijer Distribution1999-11-05Not applicableUs
12 Hour DecongestantTablet, film coated, extended release120 mg/1OralKroger1999-12-14Not applicableUs
12 Hour Nasal DecongestantTablet, film coated, extended release120 mg/1OralCvs Health1999-12-01Not applicableUs
12 Hour Nasal Decongestant Non DrowsyTablet, film coated, extended release120 mg/1OralSafeway2000-05-25Not applicableUs
Balminil Decongestionnant Sirop 30mg/5mlSyrup30 mgOralRougier Pharma Division Of Ratiopharm Inc1988-12-312000-09-07Canada
Benylin D for InfantsSyrup7.5 mgOralPfizer Canada Inc., Consumer Healthcare Division2004-08-092006-08-03Canada
Care One Suphedrine Nasal Decongestant Non DrowsyTablet, film coated30 mg/1OralAmerican Sales Company2003-12-01Not applicableUs
Careone Nasal and Sinus DecongestantTablet, film coated, extended release120 mg/1OralAmerican Sales Company2016-09-15Not applicableUs
Careone Suphedrine 12 Hour Relief Non DrowsyTablet, film coated, extended release120 mg/1OralAmerican Sales Company2004-05-11Not applicableUs
Childrens SilfedrineLiquid15 mg/5mLOralSilarx Pharmaceuticals, Inc.2001-01-05Not applicableUs
Childrens Sudafed Nasal DecongestantSolution15 mg/5mLOralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2008-10-01Not applicableUs
Childrens Uniphed Nasal DecongestantLiquid15 mg/5mLOralRij Pharmaceutical Corporation1999-03-16Not applicableUs
Congest Aid Tab 30mgTablet30 mgOralZee Medical Inc1990-12-312009-07-30Canada
Congest-eze Tab 60mgTablet60 mgOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1996-10-182002-07-31Canada
Contac Cold Nondrowsy CapsulesCapsule, extended release120 mgOralSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.1997-07-072001-07-31Canada
Contac-C Nondrowsy (sustained Release Cap)Capsule, extended release120 mgOralSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.1994-12-311997-08-15Canada
Cvs Health Non-drowsy Nasal DecongestantPill30 mg/1OralWestport Pharmaceuticals2015-10-05Not applicableUs
Cvs Health Non-drowsy Nasal DecongestantPill30 mg/1OralWestport Pharmaceuticals2015-10-05Not applicableUs
Cvs Health Non-drowsy Nasal DecongestantPill30 mg/1OralWestport Pharmaceuticals2015-10-05Not applicableUs
Decongestant TabletsTablet60 mgOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1996-12-312002-07-31Canada
Eltor 120 Srt 120mgTablet, extended release120 mgOralMerrell Dow Pharmaceuticals (Canada) Inc.1992-12-311996-08-29Canada
Ephed 60Liquid60 mg/60mLOralDickey Consumer Products DBA DMD2011-10-10Not applicableUs
Equaline 12 Hour DecongestantTablet, film coated, extended release120 mg/1OralSupervalu2004-08-10Not applicableUs
Equaline Nasal Decongestant Non Drowsy Maximum StrengthTablet, film coated30 mg/1OralSupervalu2004-08-17Not applicableUs
Equate SuphedrineTablet, film coated, extended release120 mg/1OralWalmart Stores2000-07-19Not applicableUs
Good Neighbor Pharmacy Nasal DecongestantTablet, film coated30 mg/1OralAmerisource Bergen1989-08-15Not applicableUs
Good Neighbor Pharmacy Nasal DecongestantTablet, film coated, extended release120 mg/1OralAmerisource Bergen1999-08-12Not applicableUs
Good Sense Nasal DecongestantTablet, film coated30 mg/1OralL. Perrigo Company1989-09-15Not applicableUs
Good Sense Suphedrine 12 HourTablet, film coated, extended release120 mg/1OralL. Perrigo Company1999-10-29Not applicableUs
Harris Teeter SinusTablet, film coated30 mg/1OralHarris Teeter2015-06-23Not applicableUs
Harris Teeter Sinus 12 HourTablet, film coated, extended release120 mg/1OralHarris Teeter2015-06-23Not applicableUs
Health Mart Nasal DecongestantTablet, film coated, extended release120 mg/1OralMc Kesson2012-01-11Not applicableUs
Health Mart Nasal DecongestantTablet, film coated30 mg/1OralMc Kesson2011-12-23Not applicableUs
Healthy Accents 12 Hour Nasal Decongestant Maximum StrengthTablet, film coated, extended release120 mg/1OralDza Brands,2011-07-19Not applicableUs
Healthy Accents Nasal DecongestantTablet, film coated30 mg/1OralDza Brands,2011-06-23Not applicableUs
Leader 12 Hour Nasal DecongestantTablet, film coated, extended release120 mg/1OralCardinal Health1999-07-21Not applicableUs
Leader Nasal Decongestant Maximum StrengthTablet, film coated30 mg/1OralCardinal Health1990-06-15Not applicableUs
Maxenal Caplet 120mgTablet120 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1992-12-312000-07-24Canada
Maxenal Src 240mgCapsule, extended release240 mgOralKv Pharmaceutical Company1992-12-312002-04-29Canada
Members Mark Nasal Decongestant Maximum StrengthTablet, film coated30 mg/1OralSam's West, Inc1999-02-03Not applicableUs
Nasal DecongestantTablet30 mg/1OralRugby2012-10-29Not applicableUs
Nasal DecongestantTablet, film coated30 mg/1OralCvs Health1987-07-15Not applicableUs
Nasal DecongestantTablet, film coated, extended release120 mg/1OralRebel Distributors1999-08-12Not applicableUs
Nasal DecongestantTablet, film coated30 mg/1OralPublix Supermarkets, Inc.1993-09-09Not applicableUs
Nasal DecongestantTablet, film coated30 mg/1OralL. Perrigo Company1987-07-15Not applicableUs
Nasal DecongestantTablet, sugar coated30 mg/1OralRugby2011-09-22Not applicableUs
Nasal DecongestantCapsule, gelatin coated30 mg/1OralCvs Health2017-02-09Not applicableUs
Nasal DecongestantTablet, film coated, extended release120 mg/1OralHyvee2000-09-11Not applicableUs
Nasal DecongestantTablet30 mg/1OralProficient Rx LP2012-10-29Not applicableUs
Nasal DecongestantTablet, film coated30 mg/1OralKroger1987-07-15Not applicableUs
Nasal DecongestantTablet, film coated, extended release120 mg/1OralShopko Stores Operating2014-03-10Not applicableUs
Nasal DecongestantTablet, film coated30 mg/1OralH.E.B.1981-08-25Not applicableUs
Nasal DecongestantTablet, film coated30 mg/1OralLnk International, Inc.1981-08-25Not applicableUs
Nasal DecongestantTablet, film coated30 mg/1OralShopko Stores Operating2013-09-07Not applicableUs
Nasal DecongestantTablet, sugar coated30 mg/1Oralbryant ranch prepack2011-09-22Not applicableUs
Nasal DecongestantTablet, film coated, extended release120 mg/1OralPublix Supermarkets, Inc.2000-03-20Not applicableUs
Nasal Decongestant Maximum StrengthTablet, film coated30 mg/1OralBetter Living Brands1981-08-25Not applicableUs
Nasal Decongestant Maximum StrengthTablet30 mg/1OralSupervalu1981-08-25Not applicableUs
Nasal Decongestant Maximum StrengthTablet30 mg/1OralCardinal Health1981-08-25Not applicableUs
Nasal Decongestant Maximum StrengthTablet30 mg/1OralChain Drug Marketing Association1981-08-25Not applicableUs
Nasal Decongestant Maximum StrengthTablet30 mg/1OralSunmark (Mckesson)1981-08-25Not applicableUs
Nasal Decongestant Maximum StrengthTablet, film coated30 mg/1OralChain Drug Consortium1981-08-25Not applicableUs
Nasal Decongestant Maximum Strength Non DrowsyTablet, film coated30 mg/1OralSafeway1987-07-15Not applicableUs
Nasal Decongestant Maximum Strength Non DrowsyTablet, film coated30 mg/1OralMeijer Distribution1991-02-15Not applicableUs
Nasal Decongestant Maximum Strength Non DrowsyTablet, film coated30 mg/1OralHannaford Brothers Company1995-07-05Not applicableUs
Nasal Decongestant Non DrowsyTablet, film coated30 mg/1OralHyvee1989-01-15Not applicableUs
Nasal Decongestant Non-drowsyTablet, film coated30 mg/1OralMc Kesson (Health Mart)1981-08-25Not applicableUs
Nasal Decongestant Non-drowsyTablet, film coated30 mg/1OralCvs Health1981-08-25Not applicableUs
NexafedTablet30 mg/1OralAcura Pharmaceuticals, Inc.2012-12-10Not applicableUs
Non Drowsy Regular Strength Contac Cold 12 HourTablet, extended release120 mgOralGlaxosmithkline Inc1999-08-162009-07-28Canada
Plus SinusTablet, extended release120 mgOralPfizer Canada Inc., Consumer Healthcare Division1999-02-112000-08-03Canada
Preferred Plus SinusTablet, film coated30 mg/1OralKinray2014-06-09Not applicableUs
Pseudo-timeTablet, coated30 mg/1OralTime Cap Laboratories2012-05-01Not applicableUs
Pseudoephedrine HydrochlorideTablet, extended release120 mg/1OralCardinal Health2017-02-15Not applicableUs
Pseudoephedrine HydrochlorideTablet, film coated, extended release120 mg/1OralH.E.B.2006-04-28Not applicableUs
Pseudoephedrine HydrochlorideTablet, extended release120 mg/1OralMc Kesson2017-02-20Not applicableUs
Pseudoephedrine HydrochlorideTablet, film coated, extended release120 mg/1OralMeijer Distribution2006-04-28Not applicableUs
Pseudoephedrine HydrochlorideTablet, coated30 mg/1OralAAA Pharmaceutical, Inc.2012-12-22Not applicableUs
Pseudoephedrine HydrochlorideTablet, film coated60 mg/1OralPhysicians Total Care, Inc.2002-11-25Not applicableUs
Pseudoephedrine HydrochlorideTablet, film coated, extended release120 mg/1OralCvs Health2006-04-28Not applicableUs
Pseudoephedrine HydrochlorideTablet, film coated, extended release120 mg/1OralShopko Stores Operating2006-04-28Not applicableUs
Pseudoephedrine HydrochlorideTablet, film coated30 mg/1OralPerrigo New York Inc.2008-10-17Not applicableUs
Pseudoephedrine HydrochlorideTablet, film coated, extended release120 mg/1OralRemedy Repack2015-10-27Not applicableUs
Pseudoephedrine HydrochlorideTablet, film coated, extended release120 mg/1OralChain Drug Consortium2006-04-28Not applicableUs
Pseudoephedrine HydrochlorideTablet, film coated, extended release120 mg/1OralPerrigo New York Inc.2014-05-24Not applicableUs
Pseudoephedrine HydrochlorideTablet, film coated, extended release120 mg/1OralWalgreen2006-04-28Not applicableUs
Pseudoephedrine HydrochlorideTablet, film coated120 mg/1OralOhm Laboratories, Inc.2006-04-28Not applicableUs
Pseudoephedrine HydrochlorideTablet, film coated, extended release120 mg/1OralAmerisource Bergen2006-04-28Not applicableUs
Pseudoephedrine HydrochlorideTablet, film coated, extended release120 mg/1OralSafeway2006-04-28Not applicableUs
Pseudoephedrine HydrochlorideTablet, extended release120 mg/1OralOhm Laboratories, Inc.2006-04-28Not applicableUs
Pseudoephedrine HydrochlorideTablet, film coated, extended release120 mg/1OralPublix Supermarkets, Inc.2006-04-28Not applicableUs
Pseudoephedrine HydrochlorideTablet, film coated, extended release120 mg/1OralChain Drug Marketing Association2006-04-28Not applicableUs
Pseudoephedrine Hydrochloride Srt 120mg TabTablet, extended release120 mgOralKv Pharmaceutical Company1990-05-042002-04-29Canada
Pseudoephedrine Non Drowsy FormulaTablet30 mg/1OralContract Pharmacal Corporation2001-06-21Not applicableUs
Pseudoephedrine Non-drowsy FormulaTablet60 mg/1OralContract Pharmacal Corporation2001-07-17Not applicableUs
Pulmosirum 5 Tab 60mgTablet60 mgOralNutribon (1986) Inc.1992-12-311996-09-30Canada
Robidrine Tab 60mgTablet60 mgOralWhitehall Robins Inc.1993-12-312000-07-26Canada
Rugby Nasal DecongestantLiquid30 mg/5mLOralA S Medication Solutions1999-07-26Not applicableUs
Rugby Nasal DecongestantLiquid30 mg/5mLOralbryant ranch prepack1999-07-26Not applicableUs
Rugby Nasal DecongestantLiquid30 mg/5mLOralRugby1999-07-26Not applicableUs
Rugby Nasal Decongestant Nasal DecongestantLiquid30 mg/5mLOralDispensing Solutions, Inc.1999-07-26Not applicableUs
Rx Act Nasal DecongestantTablet, film coated30 mg/1OralH.E.B.2006-02-13Not applicableUs
Shoprite Nasal DecongestantTablet, film coated, extended release120 mg/1OralWakfern Food Corporation2014-03-25Not applicableUs
Shoprite Nasal DecongestantTablet, film coated30 mg/1OralWakfern Food Corporation2013-09-17Not applicableUs
Sinus CongestionTablet, film coated30 mg/1OralL. Perrigo Company2016-10-04Not applicableUs
Sinus Pressure and Congestion Relief Maximum StrengthTablet, film coated, extended release120 mg/1OralRite Aid1999-08-30Not applicableUs
Sinus Pressure and Congestion Relief Maximum StrengthTablet30 mg/1OralRite Aid1981-08-25Not applicableUs
Smart Sense 12 Hour DecongestantTablet, film coated, extended release120 mg/1OralKmart Corporation2011-03-14Not applicableUs
Smart Sense Nasal DecongestantTablet, film coated, extended release120 mg/1OralKmart Corporation2014-02-18Not applicableUs
Smart Sense Nasal DecongestantTablet, film coated30 mg/1OralKmart Corporation2011-03-14Not applicableUs
Smart Sense SinusTablet, film coated30 mg/1OralKmart Corporation2015-08-27Not applicableUs
Smart Sense Sinus 12 HourTablet, film coated, extended release120 mg/1OralKmart Corporation2015-08-17Not applicableUs
SudafedTablet, coated30 mg/1OralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2011-10-01Not applicableUs
Sudafed 12 HourTablet, film coated, extended release120 mg/1OralA S Medication Solutions2008-06-01Not applicableUs
Sudafed 12 HourTablet, film coated, extended release120 mg/1OralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2008-06-01Not applicableUs
Sudafed 12 HourTablet, film coated, extended release120 mg/1OralA S Medication Solutions2008-06-01Not applicableUs
Sudafed 24 HourTablet, extended release240 mg/1OralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2008-10-01Not applicableUs
Sudafed Decongestant 12 Hour Caplets - 120mgTablet120 mgOralWarner Lambert Canada Inc.1996-10-111999-08-13Canada
Sudafed Decongestant Children's Chewable TabletsTablet15 mgOralPfizer Canada Inc., Consumer Healthcare Division1998-08-132006-08-03Canada
Sudafed Decongestant Extra Strength TabletTablet60 mgOralPfizer Canada Inc., Consumer Healthcare Division1998-11-302006-08-03Canada
Sudafed Decongestant Extra Strength TabletsTablet60 mgOralWarner Lambert Canada Inc.1996-10-111999-08-13Canada
Sudafed Decongestant Regular Strength SyrupSyrup30 mgOralWarner Lambert Canada Inc.1996-10-111999-08-13Canada
Sudafed Decongestant Regular Strength SyrupSyrup30 mgOralWarner Lambert Canada Inc.1998-11-302000-08-01Canada
Sudafed Decongestant Regular Strength TabletTablet30 mgOralWarner Lambert Canada Inc.1996-10-111999-08-13Canada
Sudafed Decongestant Regular Strength TabletTablet30 mgOralWarner Lambert Canada Inc.1998-11-302000-08-01Canada
Sudafed Nasal Cold 12 Hour CapletsTablet120 mgOralGlaxo Wellcome1995-12-312000-08-03Canada
Sudafed Nasal Cold Extra Strength TabletsTablet60 mgOralGlaxo Wellcome1995-12-312000-08-03Canada
Sudafed Nasal Cold Regular Strength SyrupSyrup30 mgOralGlaxo Wellcome1995-12-312000-08-03Canada
Sudafed Nasal Cold Regular Strength TabsTablet30 mgOralGlaxo Wellcome1995-12-312000-08-03Canada
Sudafed Syr 30mg/5mlSyrup30 mgOralBurroughs Wellcome1958-12-312000-08-02Canada
Sudafed Tab 60mgTablet60 mgOralBurroughs Wellcome1958-12-312000-08-02Canada
Sudodrin Tab 60mgTablet60 mgOralIcn Pharmaceuticals1979-12-311998-08-13Canada
SudogestTablet, film coated60 mg/1OralRemedy Repack2017-01-13Not applicableUs
SudogestTablet30 mg/1OralA S Medication Solutions1981-08-25Not applicableUs
SudogestTablet, film coated60 mg/1OralH.J. Harkins Company1994-10-01Not applicableUs
SudogestTablet, film coated60 mg/1OralA S Medication Solutions1994-10-01Not applicableUs
SudogestTablet30 mg/1OralRebel Distributors1994-10-01Not applicableUs
SudogestTablet, coated30 mg/1OralA S Medication Solutions2014-02-17Not applicableUs
SudogestTablet, film coated30 mg/1OralRemedy Repack2017-01-13Not applicableUs
SudogestTablet30 mg/1OralRemedy Repack2007-04-172017-03-10Us
SudogestTablet, film coated60 mg/1OralMajor1984-12-07Not applicableUs
SudogestTablet, film coated30 mg/1OralA S Medication Solutions1981-08-25Not applicableUs
SudogestTablet, film coated60 mg/1OralRebel Distributors1994-10-01Not applicableUs
SudogestLiquid15 mg/5mLOralMajor2001-01-05Not applicableUs
SudogestTablet, film coated60 mg/1OralUnit Dose Services1984-12-07Not applicableUs
SudogestTablet, film coated60 mg/1OralProficient Rx LP1994-10-01Not applicableUs
SudogestTablet60 mg/1OralDispensing Solutions, Inc.1994-10-01Not applicableUs
SudogestTablet, film coated, extended release120 mg/1OralMajor2006-04-28Not applicableUs
SudogestTablet, coated30 mg/1OralMajor2014-02-17Not applicableUs
SudogestTablet, film coated60 mg/1OralA S Medication Solutions1994-10-01Not applicableUs
SudogestTablet, film coated30 mg/1OralA S Medication Solutions1981-08-25Not applicableUs
SudogestTablet, film coated60 mg/1OralRemedy Repack2013-06-272017-12-02Us
SudogestTablet, film coated, extended release120 mg/1OralRemedy Repack2015-12-15Not applicableUs
SudogestTablet, film coated60 mg/1OralAidarex Pharmaceuticals LLC1994-10-01Not applicableUs
SudogestTablet30 mg/1OralA S Medication Solutions1981-08-25Not applicableUs
SudogestTablet, film coated30 mg/1OralMajor1981-08-25Not applicableUs
SudogestTablet, film coated30 mg/1OralRemedy Repack2012-12-14Not applicableUs
SudogestTablet, coated30 mg/1OralA S Medication Solutions2014-02-17Not applicableUs
Sudogest Nasal DecongestantTablet, film coated30 mg/1OralMajor1991-09-10Not applicableUs
Sunmark Nasal DecongestantTablet, film coated30 mg/1OralMc Kesson2003-08-15Not applicableUs
Sunmark Sinus 12 HourTablet, film coated, extended release120 mg/1OralMc Kesson2003-06-24Not applicableUs
SuphedrineTablet, film coated, extended release120 mg/1OralRite Aid2002-08-13Not applicableUs
SuphedrineTablet, film coated30 mg/1OralWalmart Stores1981-08-252017-03-13Us
Suphedrine Maximum StrengthTablet, film coated30 mg/1OralChain Drug Marketing Association1981-08-25Not applicableUs
Topcare 12 Hour DecongestantTablet, film coated, extended release120 mg/1OralTopco Associates2000-04-25Not applicableUs
Topcare Nasal Decongestant Maximum Strength Non DrowsyTablet, film coated30 mg/1OralTopco Associates1988-01-15Not applicableUs
Triaminic Allergy CongestionLiquid30 mgOralNovartis2001-07-162006-07-04Canada
Triaminic Pediatric Oral Cold Drops - 7.5mg/0.8mlLiquid7.5 mgOralNovartis1995-12-312008-07-15Canada
Up and Up 12 Hour Nasal DecongestantTablet, film coated, extended release120 mg/1OralTarget Corporation.2009-09-02Not applicableUs
Up and Up Nasal DecongestantTablet, film coated30 mg/1OralTarget Corporation.2009-08-04Not applicableUs
Up and Up Sinus 12 HourTablet, film coated, extended release120 mg/1OralTarget Corporation.2015-03-13Not applicableUs
Up and Up SuphedrineTablet, film coated30 mg/1OralTarget Corporation.2015-03-13Not applicableUs
Wal PhedTablet, film coated, extended release120 mg/1OralWalgreen1999-09-24Not applicableUs
Wal-phedTablet, film coated30 mg/1OralWalgreen1981-08-25Not applicableUs
Walphed D Maximum Strength Non Drowsy SinusTablet, film coated, extended release120 mg/1OralWalgreen1999-09-24Not applicableUs
Zephrex DCapsule, gelatin coated30 mg/1OralL. Perrigo Company2016-11-04Not applicableUs
Zephrex-DTablet30 mg/1OralWestport Pharmaceuticals2012-11-15Not applicableUs
Unapproved/Other Products Not Available
International Brands
NameCompany
AfrinolNot Available
Benylin DecongestantNot Available
CenafedNot Available
DecofedNot Available
Dimetapp DecongestantNot Available
Eltor 120Not Available
GenaphedNot Available
MaxenalNot Available
MyfedrineNot Available
NovafedNot Available
RobidrineNot Available
Sudafed DecongestantNot Available
Brand mixtures
NameLabellerIngredients
12 Hour Allergy DMeijer Distribution
A.M. Cold Relief FormulaIvax Pharmaceuticals Incorporated
Abanatuss PedKramer Novis.
Abanatuss Ped DropsKramer Novis.
Abatuss DmxKramer Novis.
Acetaminophen/dextromethorphan/pseudoephedrineApotex Corporation
Acetaminophen/pseudoephedrine/dextromethorphan/doxylamineApotex Corporation
ActiconActipharma, Inc
Actifed DM SyrupGlaxo Wellcome
Actifed DM TabletsGlaxo Wellcome
Actifed Plus CapletGlaxo Wellcome
Actifed Plus CapletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Actifed SyrupGlaxo Wellcome
Actifed TabletsGlaxo Wellcome
ActinelActipharma, Inc
Actinel PediatricActipharma, Inc
Advil Allergy SinusPfizer
Advil Cold & Sinus Convenience PackPfizer Laboratories Div Pfizer Inc.
Advil Cold & Sinus Liqui-gelsPfizer Laboratories Div Pfizer Inc.
Advil Cold and SinusPfizer Laboratories Div Pfizer Inc.
Advil Cold and Sinus DaytimePfizer Laboratories Div Pfizer Inc.
Advil Cold and Sinus NighttimePfizer Laboratories Div Pfizer Inc.
Advil Cold and Sinus PlusPfizer Laboratories Div Pfizer Inc.
Aerius Dual Action 12 HourBayer Inc Consumer Care
Aerius Dual Action 24 HourBayer Inc Consumer Care
Alavert Allergy Sinus D-12Wyeth Ltd.
Alka-seltzer Plus-D Multi-symptom Sinus and ColdBayer Health Care Llc, Consumer Care
All Day Allergy DMajor
All Day Allergy Relief DH.E.B.
All Day Allergy-DL. Perrigo Company
All Day Sinus and Cold DHyvee
Allegra D 12 Hour Allergy and CongestionRebel Distributors
Allegra D-12 HourSanofi Aventis
Allegra--d 24 HourSanofi Aventis
Allegra-Dbryant ranch prepack
Allegra-D 24 HourStat Rx USA
Allegra-D Allergy and CongestionChattem, Inc.
Allerclear-D 24 HourCostco Wholesale
Allergy + Sinus Relief Extra Strength TabletsPharmetics (2011) Inc.
Allergy + Sinus Relief Regular CapletsPharmetics (2011) Inc.
Allergy and Congestion ReliefL. Perrigo Company
Allergy and Congestion Relief D Original Prescription StrengthRite Aid
Allergy and Congestion Relief Non DrowsyAmerisource Bergen
Allergy Relief DShopko Stores Operating
Allergy Relief D 12Cvs Health
Allergy Relief D 12 HourPublix Supermarkets, Inc.
Allergy Relief D 24 HourPublix Supermarkets, Inc.
Allergy Relief-DCvs Health
Allergy Relief-D 24 HourShopko Stores Operating
Allergy Relief-d24 Hour 24 HourTopco Associates
Allergy Sinus Headache CapletsTanta Pharmaceuticals Inc
Allergy Sinus Medication - CapletWestcan Pharmaceuticals Ltd.
Allergy Sinus Nighttime ReliefVita Health Products Inc
Allergy, Sinus and Headache Relief MedicationPharmetics (2011) Inc.
Allpanto SSAMSUNG PHARM IND. CO., LTD.
AprodineRebel Distributors
Atuss DaAber Pharmaceuticals, Llc
Atuss DS Tannate SuspensionAtley Pharmaceuticals
Balminil Codeine + Decongestant + ExpectorantRougier Pharma Division Of Ratiopharm Inc
Balminil Cough and FluRougier Pharma Division Of Ratiopharm Inc
Balminil DM + DecongestantRougier Pharma Division Of Ratiopharm Inc
Balminil DM + Decongestant + ExpectorantTeva
Balminil DM + Decongestant + Expectorant Extra StrengthTeva
Balminil DM-D-E - LiqRougier Pharma Division Of Ratiopharm Inc
Benadryl Allergy & Cold CapletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benadryl Allergy Sinus CapletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benadryl Decongestant TabletsWarner Lambert Canada Inc.
Benadryl TotalMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin 2 Cold and Flu With CodeineMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin 4 Flu - SyrupPfizer Canada Inc., Consumer Healthcare Division
Benylin A-D Extra Strength CapletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin A-D Regular Strength CapletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin A-D-AH Extra Strength CapletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin A-D-AH Regular Strength CapletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin All-IN-one Cold and Flu Extra StrengthMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin All-IN-one Cold and Flu Extra Strength SyrupMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin All-IN-one Cold and Flu Liquid GelsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin All-IN-one Cold and Flu Night Extra StrengthMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin All-IN-one Cold and Flu Night Extra Strength SyrupMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin Codeine 3.3mg De SyrPfizer Canada Inc., Consumer Healthcare Division
Benylin Cough and Chest Congestion Extra Strength With Warming SensationMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin Cough and ColdMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin Cough Plus Cold ReliefMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin D-AH for ChildrenMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin DM-DMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin DM-D Chewables for ChildrenMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin DM-D for ChildrenMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin DM-D for InfantsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin DM-D-AH Chewables for ChildrenMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin DM-D-AH for ChildrenMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin DM-D-E-A Cold and Sinus Liquid GelsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin Extra Strength All-IN-one Cold and Flu With Warming SensationMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin Extra Strength Cough Plus Cold ReliefMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin Extra Strength Mucus & Phlegm Plus Cold ReliefMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin Extra Strength Mucus & Phlegm Plus Cold Relief NightMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin for Children All-IN-one Cold & FeverMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin for Children All-IN-one Cold and FeverMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin for Children Cough Stuffy and Runny NoseMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Bio Dtuss DmxAdvanced Generic Corporation
BionelAdvanced Generic Corporation
Bionel PediatricAdvanced Generic Corporation
Bromfed DMClinical Solutions Wholsesale
Bromfeddm DMPhysicians Total Care, Inc.
Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan HydrobromidePaddock Laboratories, Inc.
Brompheniramine Maleate, Pseudoephedrine Hydrochloride and DextromethorphanhydrobromideProficient Rx LP
Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan HydrobromideMorton Grove Pharmaceuticals, Inc.
Brompheniramine Maleate, Pseudoephedrine Hydrochloride, Dextromethorphan HydrobromideAcella Pharmaceuticals, LLC
Bronchodex PediatriqueTherapex Division De E Z Em Canada Inc
BrotappSilarx Pharmaceuticals, Inc.
Brotapp DM Cold and CoughSilarx Pharmaceuticals, Inc.
Brovex PsbMcr American Pharmaceuticals, Inc.
Brovex Psb DMMcr American Pharmaceuticals, Inc.
Buckley's Cold & Sinus DayThe Buckley's Company
Buckley's Cold & Sinus NightThe Buckley's Company
Buckley's Complete Daytime Plus Mucus Relief SoftgelsThe Buckley's Company
Buckley's Complete Daytime SoftgelsThe Buckley's Company
Buckley's Complete Extra Strength Cough, Cold & Flu DayThe Buckley's Company
Buckley's Complete Extra Strength Cough, Cold and Flu NightThe Buckley's Company
Buckley's Complete Nighttime SoftgelsThe Buckley's Company
Buckley's DM DecongestantThe Buckley's Company
Buckley's Sinus Pain Relief Extra Strength TabletsThe Buckley's Company
Buckleys Daytime Cold and SinusThe Buckley's Company
Buckleys Nighttime Cold and SinusThe Buckley's Company
Calmylin #2 SyrTechnilab Pharma Inc.
Calmylin #3 SyrTechnilab Pharma Inc.
Calmylin Codeine D-E SyrTechnilab Pharma Inc.
Calmylin Cough and Flu LiqTechnilab Pharma Inc.
Calmylin Pediatric SyrupTechnilab Pharma Inc.
Calmylin Pse With CodeineTeva
Capmist DMCapital Pharmaceutical
Care One Ibuprofen Cold and SinusAmerican Sales Company
Careone All Day Allergy DAmerican Sales Company
Careone Allergy and Congestion ReliefAmerican Sales Company
Careone Allergy Relief DAmerican Sales Company
Centracol Pediatrique - SyrPrometic Pharma Inc.
Cetiri DRite Aid
Cetirizine HCl and Pseudoephedrine HCl ERPhysicians Total Care, Inc.
Cetirizine HCl Pseudoephedrine HClCardinal Health
Cetirizine Hydrochloride and Pseudoephedrine HydrochlorideSun Pharmaceutical Industries Limited
Cheratussin DacQualitest
Children's Advil ColdPfizer Laboratories Div Pfizer Inc.
Children's Advil Cold & Flu Multi-symptomPfizer Laboratories Div Pfizer Inc.
Children's Allergy and Sinus Medication Liquid SuspensionPharmetics (2011) Inc.
Children's Benadryl-D Allergy & SinusMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Children's Cough & Cold ReliefTrillium Health Care Products Inc
Children's Motrin ColdMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Children's Nicold MedicineTanta Pharmaceuticals Inc
Children's Nyquil LiquidProcter And Gamble
Children's Sinus Medication Liquid SuspensionPharmetics (2011) Inc.
Children's Tussin Cough Medicine DM Antitussive DecongestantStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Children's Tylenol Allergy - D Chewable TabletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Children's Tylenol Allergy-D SuspensionMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Children's Tylenol Cold & Stuffy NoseMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Children's Tylenol Cold and CoughMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Children's Tylenol Cold Chewable TabletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Children's Tylenol Cold LiquidMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Children's Tylenol Cold Liquid With DMMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Children's Tylenol Cold SuspensionMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Children's Tylenol Complete Cold, Cough & FeverMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Children's Tylenol Decongestant - TabMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Children's Tylenol Sinus Chewable TabletMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Children's Tylenol Sinus SuspensionMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Childrens Advil ColdPfizer
Chlo TussR. A. Mc Neil Company
Chlor-tripolon Decon Ext Str Repetabs 12Schering Plough
Chlor-tripolon Nd SrtSchering Plough
Clarinex-D 12 HourMerck Sharp & Dohme Limited  
Claritin Allergy + SinusBayer Inc Consumer Care
Claritin Allergy + Sinus Extra StrengthBayer Inc Consumer Care
Claritin-D 12 HourMsd Consumer Care Inc.
Claritin-D 24 HourMsd Consumer Care Inc.
CloferaCentrix Pharmaceutical
CoactifedGlaxosmithkline Inc
Codar DRespa Pharmaceuticals
Coditussin DacGlendale Inc
Cold & CoughStrides Pharma Inc
Cold & Cough Extra StrengthStrides Pharma Inc
Cold & FluStrides Pharma Inc
Cold & Flu DaytimeArrow Otc Company
Cold & Flu NighttimeArrow Otc Company
Cold & Flu-IN-oneVita Health Products Inc
Cold & Sinus Liquid CapsulesVita Health Products Inc
Cold & Sinus Liquid FastgelsVita Health Products Inc
Cold & Sinus Relief CapsulesApotex Corporation
Cold + SinusVita Health Products Inc
Cold + Sinus CapletsVita Health Products Inc
Cold + Sinus DaytimeVita Health Products Inc
Cold + Sinus Daytime Cold + Sinus NighttimeVita Health Products Inc
Cold + Sinus NighttimeVita Health Products Inc
Cold + Sinus PlusVita Health Products Inc
Cold and Cough Relief Extra StrengthPharmetics (2011) Inc.
Cold and Flu CapsulesVita Health Products Inc
Cold and Flu Extra Strength DayPharmetics (2011) Inc.
Cold and Flu Medicine - Day Time FormulaPharmetics (2011) Inc.
Cold and Flu Medicine - Night Time FormulaPharmetics (2011) Inc.
Cold and Flu Nighttime DWalgreen
Cold and Flu Nighttime Relief Syrup Extra StrengthPharmetics (2011) Inc.
Cold and Flu-IN-one Extra StrengthVita Health Products Inc
Cold and Flu-IN-one Regular StrengthVita Health Products Inc
Cold and Nasal Congestion Relief Nighttime Extra StrengthPharmetics (2011) Inc.
Cold and Nasal Congestion Relief Super StrengthPharmetics (2011) Inc.
Cold and Sinus Complete Liquid GelsVita Health Products Inc
Cold and Sinus Daytime ReliefVita Health Products Inc
Cold and Sinus Nighttime ReliefVita Health Products Inc
Cold and Sinus Pain ReliefSafeway
Cold and Sinus PlusMarcan Pharmaceuticals Inc
Cold and Sinus ReliefCvs Health
Cold and Sinus Relief ComboVita Health Products Inc
Cold Flu ReliefPerrigo International
Cold MedicationVita Health Products Inc
Cold Medication Extra Strength DaytimePharmascience Inc
Cold Medication Extra Strength Night TimePharmascience Inc
Cold Medication Reg Strength D TabProdemdis Enr.
Cold Medication Reg Strength N TabProdemdis Enr.
Cold Medication Regular Nighttime TabletsPharmetics (2011) Inc.
Cold Relief Daytime TabletJamp Pharma Corporation
Cold Relief Duo PackPharmetics (2011) Inc.
Cold Relief Nightime TabletJamp Pharma Corporation
Cold,sore Throat Pain & Cough Ultra StrengthThe Winning Combination Inc.
Cold/flu ReliefPerrigo International
CompleteVita Health Products Inc
Complete DaytimeVita Health Products Inc
Complete Daytime Liquid CapsulesVita Health Products Inc
Complete Liquid CapsulesVita Health Products Inc
Complete Liquid Capsules Nighttime ReliefVita Health Products Inc
Complete One Cold and Flu Extra StrengthTanta Pharmaceuticals Inc
Complete One Cold and Flu Extra Strength TabletsTanta Pharmaceuticals Inc
Complete One Cold and Flu Nightime Extra Strength LiquidTanta Pharmaceuticals Inc
Complete One Cold and Flu Nightime Extra Strength TabletsTanta Pharmaceuticals Inc
ConexLlorens Pharmaceuticals International Division
CongestacBF ASCHER AND CO INC
Contac Cold and Fever CapletsGlaxosmithkline Inc
Contac Cold and Sore Throat CapletsGlaxosmithkline Inc
Contac Cold Nasal Congestion-nighttimeGlaxosmithkline Inc
Contac Cold Nasal Congestion-non Drowsy Regular StrengthGlaxosmithkline Inc
Contac Complete Cough, Cold & Flu SyrupGlaxosmithkline Inc
Contac Cough & Cold SyrupGlaxosmithkline Inc
Contac Day & Night Sinus/allergy CapletSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.
Contac Extend-C Sustained Release CapsulesGlaxosmithkline Inc
Contac Night CapletsGlaxosmithkline Inc
Contac-C Ext.stren.night Time Cough,cold&fluSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.
CopantoSAMSUNG PHARM IND. CO., LTD.
Coricidin 'd' Nasal and Sinus CongestionSchering Plough Healthcare Products Canada, A Division Of Schering Canada Inc.
Coricidin D Flu, Nasal and SinusSchering Plough Healthcare Products Canada, A Division Of Schering Canada Inc.
Coricidin D Nasal and Sinus Congestion TabletsSchering Plough Healthcare Products Canada, A Division Of Schering Canada Inc.
CotrifedTechnilab Pharma Inc.
Cough & ColdPharmetics (2011) Inc.
Cough & Cold ReliefTrillium Health Care Products Inc
Cough & Cold Relief Extra StrengthTrillium Health Care Products Inc
Cough & Cold Soft Gel CapsApotex Inc., Private Label Division
Cough and Flu SyrupTechnilab Pharma Inc.
Cough Plus Cold Relief SyrupPharmetics (2011) Inc.
Cough Syr W.cod. Pseudoephed.hcl GuaifenesinStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Cough Syrup DM - Decongestant - ExpectorantJamp Pharma Corporation
Cough Syrup DM - Decongestant - Expectorant Extra StrengthJamp Pharma Corporation
Cough Syrup DM - Decongestant for ChildrenJamp Pharma Corporation
Cough Syrup DM DecongestantJamp Pharma Corporation
Cough Syrup DM Decongestant ExpectorantStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Cough Syrup DM Decongestant for ChildrenKsl Pharmaceuticals
Cough Syrup DM-D-EWestcan Pharmaceuticals Ltd.
Cough Syrup DM-D-E With AcetaminophenSupplements Aromatik Inc.
Cough Syrup DM-D-E With Acetaminophen Extra StrengthSupplements Aromatik Inc.
Cough Syrup With CodeineTeva
Cough, Cold & FluVita Health Products Inc
Cough, Cold & Flu Super StrengthThe Winning Combination Inc.
Cough, Cold and Flu Daytime CapletsVita Health Products Inc
Cough, Cold and Flu Nightime CapletsVita Health Products Inc
Cough, Cold and Flu Relief Complete Night Super StrengthPharmetics (2011) Inc.
Cough, Cold and Flu Relief Day Super StrengthPharmetics (2011) Inc.
Covan SyrupPharmascience Inc
Day & Night Combo PackThe Winning Combination Inc.
Day Relief Cold and Flu Liquid CapsulesBanner Pharmacaps
Day Time Liquid CapsIvax Pharmaceuticals Incorporated
Day Time Multi Symptom ReliefStrides Pharma Inc
Day Time ReliefStrides Pharma Inc
Day Time Relief Extra StrengthStrides Pharma Inc
Daycap Cold & Sinus Liquid GelsAccucaps Industries Limited
Dayquil DProcter And Gamble
Dayquil LiquicapsProcter And Gamble
Dayquil Liquicaps - CapProcter And Gamble
Dayquil Medicine - LiqProcter And Gamble
Daytime 325 Liqua CapsJamp Pharma Corporation
Daytime Cold & Flu Liquid CapsulesVita Health Products Inc
Daytime Cold and Flu Liquid CapsulesBanner Pharmacaps
Daytime Cold and Flu ReliefPharmetics (2011) Inc.
Daytime Cold Medication Liquid FastgelsVita Health Products Inc
Daytime Cold Relief CapletsPharmetics (2011) Inc.
Daytime Cold Relief Extra Strength TabletsPharmetics (2011) Inc.
Daytime Cold/flu ReliefPerrigo International
Daytime Cough. Cold. Flu Gel CapsulesApotex Inc., Private Label Division
Daytime Flu Relief Extra StrengthPharmetics (2011) Inc.
Daytime Liqua CapsJamp Pharma Corporation
Daytime Liquid - LiqPerrigo International
Daytime Sinus Relief Extra Strength TabletsPharmetics (2011) Inc.
Deltuss Dmx Cough Suppressant Nasal Decongestant Antihistamine Grape FlavorDeliz Pharmaceutical Corp
Deltuss Dp Nasal Decongestant Antihistamine Cherry FlavorDeliz Pharmaceutical Corp
Demdec SyrRougier Pharma Division Of Ratiopharm Inc
Desgen DM TabsKramer Novis.
Despec-DM TabsInternational Ethical Labs.
Despec-tabInternational Ethical Labs.
Dexbrompherniramine Maleate and Pseudoephedrine Sulfate 6mg/120mgKvk Tech,Inc
Dicel CDCentrix Pharmaceutical
Dimetane DxCreekwood Pharmaceuticals, Inc.
Dimetapp Children's Cough and Cold LiquidWhitehall Robins Inc.
Dimetapp Cold and Sinus CapletsWhitehall Robins Inc.
Dimetapp Cough & Congestion LiquidWyeth Ltd.
Dimetapp Daytime Cold CapletsWyeth Ltd.
Dimetapp Daytime Cold Extra Strength CapletsPfizer Laboratories Div Pfizer Inc.
DM Plus Decongestant Cough SyrupTechnilab Pharma Inc.
DM Plus Decongestant Plus Expector.ex.st.syrTechnilab Pharma Inc.
DM Plus Decongestant Plus Expectorant Cough SyrupTechnilab Pharma Inc.
DM-D-expectorant Cough and Cold SyrupD.C. Labs Limited
DM-decongestant Children's SyrupTrillium Health Care Products Inc
DM-decongestant SyrupTrillium Health Care Products Inc
DM-decongestant-expectorant (extra Strength) SyrupTrillium Health Care Products Inc
DM-decongestant-expectorant SyrupTrillium Health Care Products Inc
Dristan Nd CapletsPfizer Laboratories Div Pfizer Inc.
Dristan Non-drowsy Extra Strength CapletPfizer Laboratories Div Pfizer Inc.
Dristan Sinus CapletsWhitehall Robins Inc.
Drixoral Cold & SinusBayer Inc Consumer Care
Drixoral Day/night - Srt/tabsSchering Plough
Drixoral SyrupSchering Plough
Drixtab TabSchering Plough
Dry Cough & Cold SyrupPharmetics (2011) Inc.
DrymaxJay Mac Pharmaceuticals
Drymax AFJay Mac Pharmaceuticals
DurafluPoly Pharmaceuticals
Ed-A-hist PseEdwards Pharmaceuticals, Inc
Entex LAPurdue Pharma
Entex TWraser Pharmaceuticals
Entre-coughAcella Pharmaceuticals, LLC
Entre-SBrookstone Pharmaceuticals, Inc.
Ephed Plus SinusDickey Consumer Products DBA DMD
Equaline All Day Allergy DSupervalu
Equaline Allergy and Congestion ReliefSupervalu
Equaline Ibuprofen Cold and SinusSupervalu
Equate Allergy Relief DWalmart Stores
Equate Daytime Liquid CapsulesIvax Pharmaceuticals Incorporated
Equate Ibuprofen Cold and SinusWalmart Stores
Equate Nighttime Liquid CapsulesIvax Pharmaceuticals Incorporated
Exefen DmxLarken Laboratories, Inc.
Expectorant DM Cough Extra Strength With DecongestantTanta Pharmaceuticals Inc
Extra Strength Allergy and Sinus ReliefPendopharm Division Of De Pharmascience Inc
Extra Strength Allergy Plus Sinus ReliefKsl Pharmaceuticals
Extra Strength Allergy Sinus MedicationStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Extra Strength Allergy TotalVita Health Products Inc
Extra Strength Cold Medication Daytime ReliefVita Health Products Inc
Extra Strength Cold Medication Daytime RlfStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Extra Strength Cold Medication Nighttime ReliefVita Health Products Inc
Extra Strength Cold Medication Nighttime RlfStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Extra Strength Cough Plus Cold Relief SyrupPharmetics (2011) Inc.
Extra Strength Day and Night Cold MedicationPendopharm Division Of De Pharmascience Inc
Extra Strength Daytime Cold ReliefPendopharm Division Of De Pharmascience Inc
Extra Strength Daytime Cold Relief-capletKsl Pharmaceuticals
Extra Strength Flu Relief DaytimeVita Health Products Inc
Extra Strength Flu Relief NightimeVita Health Products Inc
Extra Strength Head Cold and SinusVita Health Products Inc
Extra Strength Neocitran Flu NightNovartis
Extra Strength Neocitran Total NightNovartis
Extra Strength Nighttime Cold ReliefPendopharm Division Of De Pharmascience Inc
Extra Strength Nighttime Cold Relief-capletKsl Pharmaceuticals
Extra Strength Sinus Medication-capletStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Extra Strength Sinus ReliefPendopharm Division Of De Pharmascience Inc
Extra Strength Sinus Relief DaytimeVita Health Products Inc
Extra Strength Sinus Relief NighttimeVita Health Products Inc
Extra Strength Sinus Relief-capletKsl Pharmaceuticals
Extra Strength Tylenol Allergy Sinus CapletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Allergy Sinus Nighttime CapletMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Cold & Sinus DaytimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Cold & Sinus NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Cold and Flu PowderMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Cold DaytimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Cold Nighttime CapletMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Complete Cold, Cough & FluMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Complete Cold, Cough & Flu DaytimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Complete Cold, Cough & Flu NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Complete Cold, Cough & Flu Plus Mucus ReliefMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Complete Cold, Cough & Flu Plus Mucus Relief NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Flu DaytimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Flu Nighttime GelcapMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Sinus Pain and Congestion DaytimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Sinus Pain and Congestion NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Fexofenadine HCl and Pseudoephedrine HciWalgreens
Fexofenadine HCl and Pseudoephedrine HClDr Reddy's Laboratories
Fexofenadine Hydrochloride and Pseudoephedrine HydrochlorideRebel Distributors
Flu ReliefVita Health Products Inc
Flu, Cough & Cold CompleteVita Health Products Inc
Flu, Cough & Cold Complete Day and NightVita Health Products Inc
Formule 115 DMFrega Inc.
G-con-XMclaren Medical Inc
G-tuss-NLMclaren Medical Inc
G-tuss-NL PedMclaren Medical Inc
G-xpect PseMclaren Medical Inc
GlentussGlendale Inc
Good Neighbor Pharmacy All Day Allergy DAmerisource Bergen
Good Neighbor Pharmacy Childrens Ibuprofen ColdAmerisource Bergen
Good Neighbor Pharmacy Ibuprofen Cold and SinusAmerisource Bergen
Good Neighbor Pharmacy Loratadine DAmerisource Bergen
Good Neighbor Pharmacy Loratadine D 24 HourAmerisource Bergen
Good Neighbor Pharmacy Mucus DAmerisource Bergen
Good Neighbor Pharmacy Night Time DAmerisource Bergen
Good Neighbor Pharmacy Sinus and Cold DAmerisource Bergen
Good Sense All Day Allergy DL. Perrigo Company
Good Sense Allergy and Congestion ReliefL. Perrigo Company
Good Sense Allergy and Congestion Relief Non Drowsy 24 HourL. Perrigo Company
Good Sense Ibuprofen Cold and SinusL. Perrigo Company
Good Sense Mucus DL. Perrigo Company
GripmaxUnipharm, Inc.
Guaifenesin and Pseudoephedrine Hydrochloride Extended ReleasePerrigo New York Inc.
Guaifenesin DacRising Pharmaceuticals
Harris Teeter All Day Allergy DHarris Teeter
Harris Teeter Allergy and Congestion ReliefHarris Teeter
Harris Teeter Mucus Relief DHarris Teeter
Head Cold and Sinus Relief CapletsPharmetics (2011) Inc.
Health Mart Allergy and CongestionMc Kesson
Health Mart Allergy Complete DMc Kesson
Health Mart Mucus Relief DMc Kesson
Health Mart Sinus and Cold DMc Kesson
Healthy Accents Allergy and Congestion Relief 24 Hour Non DrowsyDza Brands,
Healthy Accents Cetirizine-DDza Brands,
Healthy Accents Mucus Relief DDza Brands,
Histenol Cold TabletsZee Medical Inc
Hot Lemon Night Time Total Extra StrengthPharmetics (2011) Inc.
Hot Lemon Relief for Sore Throat and Cough Extra StrengthJamp Pharma Corporation
Hot Lemon Relief for Symptoms Of Cough, Cold and FluPatheon Laboratories
Hot Lemon Relief for Symptoms Of Cough, Cold and Flu Extra StrengthPharmetics (2011) Inc.
HycofenixMission Pharmacal
Hydrocodone Bitartrate and Pseudoephedrine Hydrochloride SolutionTris Pharma, Inc.
Hydrocodone Bitartrate, Chlorpheniramine Maleate and Pseudoephedrine HydrochloridePaddock Laboratories, Inc.
Hydrocodone Bitartrate, Chlorpheniramine Maleate, and Pseudoephedrine HClCypress Pharmaceuticals, Inc.
Hydrocodone Bitartrate, Chlorpheniramine Maleate, and Pseudoephedrine Hydrochloride Oral SolutionTris Pharma, Inc.
Ibu Profen Cold and SinusRite Aid
Ibuprofen + Pseudoephedrine CapletsMarcan Pharmaceuticals Inc
Ibuprofen and PseudoephedrineMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Ibuprofen and Pseudoephedrine HydrochlorideWalgreen
Ibuprofen Cold and SinusKroger
Ibuprofen Cold and Sinus A P JA P J Laboratories Limited
Ibuprofen Cold ChildrensMeijer Distribution
Ibuprofen Cold Relief ChildrensCvs Health
Infants Tylenol Cold Suspension DropsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
J-cof DhcJay Mac Pharmaceuticals
J-tan D PdJay Mac Pharmaceuticals
Jack & Jill Cough and ColdThe Buckley's Company
Jack & Jill Cough, Cold & Flu Junior Strength TabletsThe Buckley's Company
Junior Strength Cold DM - TabletVita Health Products Inc
Junior Strength Tylenol Cold and CoughMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Junior Strength Tylenol Complete Cold, Cough & FeverMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Junior Strength Tylenol Decongestant - TabMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Kidkare Cough/coldRugby
Kirkland Signature Aller Tec DCostco Wholesale
Kirkland Signature Allerclear D 12 HrCostco Wholesale
Kirkland Signature Allerclear D 24hrCostco Wholesale
Koffex DM + Decongestant SyrupTechnilab Pharma Inc.
Koffex DM + Decongestant + ExpectorantTechnilab Pharma Inc.
Koffex DM + Decongestant + Expectorant Extra StrengthTechnilab Pharma Inc.
Koffex DM-D-E - LiqRougier Pharma Division Of Ratiopharm Inc
Leader Allergy D 12Cardinal Health
Leader Allergy Relief D-24Cardinal Health
Leader Ibuprofen Cold and SinusCardinal Health
Leader Ibuprofen Cold ChildrensCardinal Health
Leader Sinus and Cold-DCardinal Health
LiberatorSchering Plough
Lodrane DECR Pharmaceuticals Co., Inc.
Lohist DLarken Laboratories, Inc.
Loratadine and PseudoephedrineWalgreen
Loratadine and Pseudoephedrine SulfateMajor
Loratadine Dbryant ranch prepack
Loratadine D 24 HourPerrigo New York Inc.
Lortuss DMSallus Laboratories, Llc
Lortuss EXSallus Laboratories, Llc
Lortuss LqPoly Pharmaceuticals
M-end DMR. A. Mc Neil Company
M-end DmxR. A. Mc Neil Company
M-end Max DR. A. Mc Neil Company
M-end WcR. A. Mc Neil Company
Mar-cof BPMarnel Pharmaceuticals, Llc
Maux De Gorge Et De LA Toux Extra-fortPharmalab Inc.
Maximum Strength Allergy SinusWalgreen
Medicament Pour Le Rhume, JourLaboratoire Riva Inc
Medicament Pour Le Rhume, NuitLaboratoire Riva Inc
Medicament Pour Les Sinus Reg CapletProdemdis Enr.
Medicament Pour Les Sinus, Extra-fortLaboratoire Riva Inc
Medicament Pour Les Sinus, RegulierLaboratoire Riva Inc
Medicament Sinus Personnel EX-fort CapletProdemdis Enr.
Medicament Sinus Personnel Reg CapletProdemdis Enr.
Medicine Shoppe Allergy Relief D24Medicine Shoppe International
Motrin Cold & Sinus CapletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Motrin Cold & Sinus PainMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Mucinex DPhysicians Total Care, Inc.
Mucinex D Maximum StrengthReckitt Benckiser
Mucus DMeijer Distribution
Mucus D ERPublix Supermarkets, Inc.
Mucus Relief DRite Aid
Neo AcLaser Pharmaceuticals Llc
Neo Citran Daycaps Extra Strength - CapletNovartis
Neo DMLaser Pharmaceuticals Llc
Neocitran Cold & Flu SyrupNovartis
Neocitran Cough & Cold SyrupNovartis
Neocitran Ultra Strength Total FluGlaxosmithkline Inc
Neocitran Ultra Strength Total Flu NightGlaxosmithkline Inc
Nicold Medicine for AdultsTanta Pharmaceuticals Inc
Night Relief Cold and Flu Liquid CapsulesBanner Pharmacaps
Night Time Cold and FluSafeway
Night Time Multi Symptom ReliefStrides Pharma Inc
Night Time ReliefStrides Pharma Inc
Night Time Total Extra StrengthPharmetics (2011) Inc.
Nightcap Complete Liquid GelsAccucaps Industries Limited
Nighttime 325 Liqua CapsJamp Pharma Corporation
Nighttime Cold & Flu Liquid CapsulesVita Health Products Inc
Nighttime Cold & Flu Relief SyrupPharmetics (2011) Inc.
Nighttime Cold and Flu Extra Strength MedicineJamp Pharma Corporation
Nighttime Cold and Flu Liquid CapsulesVita Health Products Inc
Nighttime Cold and Flu ReliefPharmetics (2011) Inc.
Nighttime Cold and Flu-IN-one Extra StrengthVita Health Products Inc
Nighttime Cold Relief Extra Strength TabletsPharmetics (2011) Inc.
Nighttime Cough. Cold. Flu Gel CapsulesApotex Inc., Private Label Division
Nighttime D Cold and FluHyvee
Nighttime D Cold and Flu ReliefWalgreen
Nighttime Flu, Cough & Cold Complete Relief Extra StrengthVita Health Products Inc
Nighttime Liqua CapsJamp Pharma Corporation
Nighttime Super Strength Contac CompleteGlaxosmithkline Inc
Nighttime Total Cold and FluVita Health Products Inc
Nighttime Total Super StrengthThe Winning Combination Inc.
Nite Time (children's)Perrigo International
NitetimeKroger
Nitetime Cold MedicineIvc Industries, Hall Division
Nitetime Cold Medicine LiqJamp Pharma Corporation
Nitetime Cold Medicine Original and CherryWestcan Pharmaceuticals Ltd.
Nitetime DMeijer Distribution
Nitetime D Multi Symptom Cold Flu ReliefMeijer Distribution
Non Drowsy Extra Strength Contac Cold Sore ThroatGlaxosmithkline Inc
Non Drowsy Regular Strength Contac Cold Chest CongestionGlaxosmithkline Inc
Non Drowsy Regular Strength Contac CompleteGlaxosmithkline Inc
Non Drowsy Super Strength Contac Cold Nasal CongestionGlaxosmithkline Inc
Non Drowsy Super Strength Contac CompleteGlaxosmithkline Inc
Notuss-nxdSj Pharmaceuticals, Llc
Novahistex DM Expectorant With DecongestantW.K. Buckley Ltd.
Novahistex DM With DecongestantW.K. Buckley Ltd.
Novahistex Expectorant With DecongestantHoechst Marion Roussel
Novahistine DM Expectorant With DecongestantW.K. Buckley Ltd.
Novahistine DM With Decongestant - LiqW.K. Buckley Ltd.
Nyquil LiquicapsProcter And Gamble
Once-A-day Benylin Cold CapKv Pharmaceutical Company
P.M. Cold Relief FormulaIvax Pharmaceuticals Incorporated
Pain & Fever + ColdAccudial Pharmaceutical, Inc.
Pain & Fever + Cold & CoughAccudial Pharmaceutical, Inc.
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Robitussin Honey Cough and ColdWhitehall Robins Inc.
Robitussin Honey FluWhitehall Robins Inc.
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Shoprite Allergy and Congestion ReliefWakfern Food Corporation
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Signature Care Allergy Relief DSafeway
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Sinus and Cold DL. Perrigo Company
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Sinus Medication Day & NightVita Health Products Inc
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Sinutab N.D.reg Strength TabMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
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Smart Sense Allergy and Congestion Relief DKmart Corporation
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Smart Sense Allergy and Congestion Relief-DKmart Corporation
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SudogestMajor
Sunmark All Day Allergy DMc Kesson
Sunmark Ibuprofen Cold and SinusMc Kesson
Sunmark Loratadine DMc Kesson
Sunmark Mucus Relief DMc Kesson
Sunmark Nite Time D Cold and FluMc Kesson
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Syrup DM-DTherapex Division De E Z Em Canada Inc
Syrup DM-D-ETherapex Division De E Z Em Canada Inc
Theraflu Flu Cold and Cough MedicineSandoz
Theraflu Max-DNovartis
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Triaminic CoughNovartis
Triaminic Cough and CongestionNovartis
Triaminic Cough and Sore ThroatNovartis
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Triaminic DM Expectorant SyrNovartis
Triaminic DM Plus Decongestant SyrupSandoz
Triaminic DM+decongestant Liqui-gels CapsulesSandoz
Triaminic Expectorant SyrNovartis
Triaminic Softchews Cold and AllergyNovartis
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Tricode GfRespa Pharmaceuticals
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Triprofed TabIcn Pharmaceuticals
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Vicks Formula 44m LiqProcter And Gamble
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Vicks Nyquil D Cold and Flu Nighttime ReliefProcter And Gamble
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Wal Itin DWalgreen
Wal Itin D 12 Hour Allergy and CongestionWalgreen
Wal Itin D Non DrowsyWalgreen
Wal Itin D Non Drowsy 24 Hour Allergy and CongestionWalgreen
Wal Profen Cold and SinusWalgreen
Wal Zyr DWalgreen
Wal Zyr D Allergy and CongestionWalgreen
Wal-actWalgreen
Wal-finate DWalgreen
Wal-itin D 24 HourWalgreen
Wal-phedWalgreen
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Zodryl Dec 25Coda Dose, Inc.
Zodryl Dec 30Coda Dose, Inc.
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Categories
UNII7CUC9DDI9F
CAS number90-82-4
WeightAverage: 165.2322
Monoisotopic: 165.115364107
Chemical FormulaC10H15NO
InChI KeyKWGRBVOPPLSCSI-WCBMZHEXSA-N
InChI
InChI=1S/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/t8-,10+/m0/s1
IUPAC Name
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol
SMILES
CN[C@@H](C)[C@@H](O)C1=CC=CC=C1
Pharmacology
IndicationFor the treatment of nasal congestion, sinus congestion, Eustachian tube congestion, and vasomotor rhinitis, and as an adjunct to other agents in the optimum treatment of allergic rhinitis, croup, sinusitis, otitis media, and tracheobronchitis. Also used as first-line therapy of priapism.
Structured Indications
PharmacodynamicsPseudoephedrine is a sympathomimetic agent, structurally similar to ephedrine, used to relieve nasal and sinus congestion and reduce air-travel-related otalgia in adults. The salts pseudoephedrine hydrochloride and pseudoephedrine sulfate are found in many over-the-counter preparations either as single-ingredient preparations, or more commonly in combination with antihistamines and/or paracetamol/ibuprofen. Unlike antihistamines, which modify the systemic histamine-mediated allergic response, pseudoephedrine only serves to relieve nasal congestion commonly associated with colds or allergies. The advantage of oral pseudoephedrine over topical nasal preparations, such as oxymetazoline, is that it does not cause rebound congestion (rhinitis medicamentosa).
Mechanism of actionPseudoephedrine acts directly on both alpha- and, to a lesser degree, beta-adrenergic receptors. Through direct action on alpha-adrenergic receptors in the mucosa of the respiratory tract, pseudoephedrine produces vasoconstriction. Pseudoephedrine relaxes bronchial smooth muscle by stimulating beta2-adrenergic receptors. Like ephedrine, pseudoephedrine releasing norepinephrine from its storage sites, an indirect effect. This is its main and direct mechanism of action. The displaced noradrenaline is released into the neuronal synapse where it is free to activate the postsynaptic adrenergic receptors.
TargetKindPharmacological actionActionsOrganismUniProt ID
Sodium-dependent noradrenaline transporterProteinyes
inhibitor
HumanP23975 details
Sodium-dependent dopamine transporterProteinyes
inhibitor
HumanQ01959 details
Alpha-1A adrenergic receptorProteinyes
agonist
HumanP35348 details
Alpha-2A adrenergic receptorProteinyes
agonist
HumanP08913 details
Sodium-dependent serotonin transporterProteinyes
inhibitor
HumanP31645 details
Beta-2 adrenergic receptorProteinunknown
partial agonist
HumanP07550 details
Beta-1 adrenergic receptorProteinunknown
agonist
partial agonist
HumanP08588 details
Nuclear factor of activated T-cells, cytoplasmic 1ProteinunknownNot AvailableHumanO95644 details
Tumor necrosis factorProteinunknownNot AvailableHumanP01375 details
Nuclear factor kappa-light-chain-enhancer of activated B cellsProteinunknownNot AvailableHumannot applicabledetails
activator protein 1Protein groupunknownNot AvailableHumannot applicabledetails
Interleukin-2ProteinunknownNot AvailableHumanP60568 details
Related Articles
AbsorptionPseudoephedrine is readily and almost completely absorbed from the GI tract and there is no evidence of first-pass metabolism.
Volume of distributionNot Available
Protein bindingPseudoephedrine does not bind to human plasma proteins over the concentration range of 50 to 2000 ng/mL
Metabolism

Hepatic.

Route of eliminationNot Available
Half life9-16 hours
ClearanceNot Available
ToxicityCommon adverse reactions include nervousness, restlessness, and insomnia. Rare adverse reactions include difficult/painful urination, dizziness/lightheadedness, heart palpitations, headache, increased sweating, nausea/vomiting, trembling, troubled breathing, unusual paleness, and weakness.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions
DrugInteractionDrug group
7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE may increase the hypertensive activities of Pseudoephedrine.Experimental
AbirateroneThe serum concentration of Pseudoephedrine can be increased when it is combined with Abiraterone.Approved
AcebutololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Acebutolol.Approved
AcepromazineAcepromazine may decrease the stimulatory activities of Pseudoephedrine.Approved, Vet Approved
AceprometazineAceprometazine may decrease the stimulatory activities of Pseudoephedrine.Approved
AcetazolamideAcetazolamide may decrease the excretion rate of Pseudoephedrine which could result in a higher serum level.Approved, Vet Approved
AcetophenazineAcetophenazine may decrease the stimulatory activities of Pseudoephedrine.Approved
AcrivastinePseudoephedrine may decrease the sedative activities of Acrivastine.Approved
AlcaftadinePseudoephedrine may decrease the sedative activities of Alcaftadine.Approved
AlfentanilPseudoephedrine may increase the analgesic activities of Alfentanil.Approved, Illicit
AlfuzosinAlfuzosin may decrease the vasoconstricting activities of Pseudoephedrine.Approved, Investigational
AlimemazinePseudoephedrine may decrease the sedative activities of Alimemazine.Approved, Vet Approved
AlphacetylmethadolPseudoephedrine may increase the analgesic activities of Alphacetylmethadol.Experimental, Illicit
AlprenololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Alprenolol.Approved, Withdrawn
Aluminum hydroxideAluminum hydroxide may decrease the excretion rate of Pseudoephedrine which could result in a higher serum level.Approved
AmineptineAmineptine may decrease the antihypertensive activities of Pseudoephedrine.Illicit, Withdrawn
AmiodaroneThe metabolism of Pseudoephedrine can be decreased when combined with Amiodarone.Approved, Investigational
AmisulprideAmisulpride may decrease the stimulatory activities of Pseudoephedrine.Approved, Investigational
AmitriptylineAmitriptyline may decrease the antihypertensive activities of Pseudoephedrine.Approved
Ammonium chlorideThe serum concentration of Pseudoephedrine can be decreased when it is combined with Ammonium chloride.Approved, Vet Approved
AmperozideAmperozide may decrease the stimulatory activities of Pseudoephedrine.Experimental
AmphetamineThe risk or severity of adverse effects can be increased when Amphetamine is combined with Pseudoephedrine.Approved, Illicit
AntazolinePseudoephedrine may decrease the sedative activities of Antazoline.Approved
AripiprazoleAripiprazole may decrease the stimulatory activities of Pseudoephedrine.Approved, Investigational
ArotinololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Arotinolol.Approved
ArtemetherThe metabolism of Pseudoephedrine can be decreased when combined with Artemether.Approved
AsenapineAsenapine may decrease the stimulatory activities of Pseudoephedrine.Approved
AstemizolePseudoephedrine may decrease the sedative activities of Astemizole.Approved, Withdrawn
AtenololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Atenolol.Approved
AtomoxetineAtomoxetine may increase the hypertensive activities of Pseudoephedrine.Approved
AzatadinePseudoephedrine may decrease the sedative activities of Azatadine.Approved
AzelastinePseudoephedrine may decrease the sedative activities of Azelastine.Approved
BefunololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Befunolol.Experimental
BenmoxinBenmoxin may increase the hypertensive activities of Pseudoephedrine.Withdrawn
BenzphetamineThe risk or severity of adverse effects can be increased when Benzphetamine is combined with Pseudoephedrine.Approved, Illicit
Benzylpenicilloyl PolylysinePseudoephedrine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.Approved
BetaxololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Betaxolol.Approved
BevantololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Bevantolol.Approved
BezitramidePseudoephedrine may increase the analgesic activities of Bezitramide.Experimental, Illicit, Withdrawn
BifeprunoxBifeprunox may decrease the stimulatory activities of Pseudoephedrine.Investigational
Bismuth SubcitrateBismuth Subcitrate may decrease the excretion rate of Pseudoephedrine which could result in a higher serum level.Approved
BisoprololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Bisoprolol.Approved
BopindololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Bopindolol.Approved
BrexpiprazoleBrexpiprazole may decrease the stimulatory activities of Pseudoephedrine.Approved
BromocriptineBromocriptine may increase the hypertensive activities of Pseudoephedrine.Approved, Investigational
BrompheniraminePseudoephedrine may decrease the sedative activities of Brompheniramine.Approved
BuclizinePseudoephedrine may decrease the sedative activities of Buclizine.Approved
BufuralolPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Bufuralol.Experimental, Investigational
BupranololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Bupranolol.Approved
BuprenorphinePseudoephedrine may increase the analgesic activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Pseudoephedrine can be decreased when combined with Bupropion.Approved
ButorphanolPseudoephedrine may increase the analgesic activities of Butorphanol.Approved, Illicit, Vet Approved
Butyric AcidPseudoephedrine may decrease the sedative activities of Butanoic Acid.Experimental
CabergolineCabergoline may increase the hypertensive activities of Pseudoephedrine.Approved
Calcium carbonateCalcium carbonate may decrease the excretion rate of Pseudoephedrine which could result in a higher serum level.Approved
CarbinoxaminePseudoephedrine may decrease the sedative activities of Carbinoxamine.Approved
CarfentanilPseudoephedrine may increase the analgesic activities of Carfentanil.Illicit, Vet Approved
CariprazineCariprazine may decrease the stimulatory activities of Pseudoephedrine.Approved
CaroxazoneCaroxazone may increase the hypertensive activities of Pseudoephedrine.Withdrawn
CarteololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Carteolol.Approved
CarvedilolPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Carvedilol.Approved, Investigational
CelecoxibThe metabolism of Pseudoephedrine can be decreased when combined with Celecoxib.Approved, Investigational
CeliprololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Celiprolol.Approved, Investigational
CetirizinePseudoephedrine may decrease the sedative activities of Cetirizine.Approved
ChloropyraminePseudoephedrine may decrease the sedative activities of Chloropyramine.Approved
ChloroquineThe metabolism of Pseudoephedrine can be decreased when combined with Chloroquine.Approved, Vet Approved
ChlorphenaminePseudoephedrine may decrease the sedative activities of Chlorphenamine.Approved
ChlorphenoxaminePseudoephedrine may decrease the sedative activities of Chlorphenoxamine.Withdrawn
ChlorphentermineThe risk or severity of adverse effects can be increased when Chlorphentermine is combined with Pseudoephedrine.Illicit, Withdrawn
ChlorpromazineThe metabolism of Pseudoephedrine can be decreased when combined with Chlorpromazine.Approved, Vet Approved
ChlorprothixeneChlorprothixene may decrease the stimulatory activities of Pseudoephedrine.Approved, Withdrawn
CholecalciferolThe metabolism of Pseudoephedrine can be decreased when combined with Cholecalciferol.Approved, Nutraceutical
CimetidineThe metabolism of Pseudoephedrine can be decreased when combined with Cimetidine.Approved
CinacalcetThe metabolism of Pseudoephedrine can be decreased when combined with Cinacalcet.Approved
CinnarizinePseudoephedrine may decrease the sedative activities of Cinnarizine.Approved
CitalopramThe metabolism of Pseudoephedrine can be decreased when combined with Citalopram.Approved
ClemastineThe metabolism of Pseudoephedrine can be decreased when combined with Clemastine.Approved
ClenbuterolThe risk or severity of adverse effects can be increased when Clenbuterol is combined with Pseudoephedrine.Approved, Vet Approved
ClobazamThe metabolism of Pseudoephedrine can be decreased when combined with Clobazam.Approved, Illicit
ClomipramineClomipramine may decrease the antihypertensive activities of Pseudoephedrine.Approved, Vet Approved
ClotrimazoleThe metabolism of Pseudoephedrine can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe metabolism of Pseudoephedrine can be decreased when combined with Clozapine.Approved
CobicistatThe serum concentration of Pseudoephedrine can be increased when it is combined with Cobicistat.Approved
CocaineThe metabolism of Pseudoephedrine can be decreased when combined with Cocaine.Approved, Illicit
CodeinePseudoephedrine may increase the analgesic activities of Codeine.Approved, Illicit
CyamemazineCyamemazine may decrease the stimulatory activities of Pseudoephedrine.Approved
CyclizinePseudoephedrine may decrease the sedative activities of Cyclizine.Approved
CyclobenzaprineCyclobenzaprine may decrease the antihypertensive activities of Pseudoephedrine.Approved
CyproheptadinePseudoephedrine may decrease the sedative activities of Cyproheptadine.Approved
DapiprazoleDapiprazole may decrease the stimulatory activities of Pseudoephedrine.Approved
DarifenacinThe metabolism of Pseudoephedrine can be decreased when combined with Darifenacin.Approved, Investigational
DarunavirThe serum concentration of Pseudoephedrine can be increased when it is combined with Darunavir.Approved
DelavirdineThe metabolism of Pseudoephedrine can be decreased when combined with Delavirdine.Approved
DesipramineDesipramine may decrease the antihypertensive activities of Pseudoephedrine.Approved
DesloratadinePseudoephedrine may decrease the sedative activities of Desloratadine.Approved, Investigational
DesvenlafaxineDesvenlafaxine may increase the tachycardic activities of Pseudoephedrine.Approved
DexbrompheniraminePseudoephedrine may decrease the sedative activities of Dexbrompheniramine.Approved
Dexchlorpheniramine maleatePseudoephedrine may decrease the sedative activities of Dexchlorpheniramine maleate.Approved
DextromoramidePseudoephedrine may increase the analgesic activities of Dextromoramide.Experimental, Illicit
DextropropoxyphenePseudoephedrine may increase the analgesic activities of Dextropropoxyphene.Approved, Illicit, Withdrawn
DezocinePseudoephedrine may increase the analgesic activities of Dezocine.Approved
DiclofenamideDiclofenamide may decrease the excretion rate of Pseudoephedrine which could result in a higher serum level.Approved
DihydrocodeinePseudoephedrine may increase the analgesic activities of Dihydrocodeine.Approved, Illicit
DihydroergotamineDihydroergotamine may increase the hypertensive activities of Pseudoephedrine.Approved
DihydroetorphinePseudoephedrine may increase the analgesic activities of Dihydroetorphine.Experimental, Illicit
DihydromorphinePseudoephedrine may increase the analgesic activities of Dihydromorphine.Experimental, Illicit
DimenhydrinatePseudoephedrine may decrease the sedative activities of Dimenhydrinate.Approved
DimetindenePseudoephedrine may decrease the sedative activities of Dimetindene.Approved
DimetotiazinePseudoephedrine may decrease the sedative activities of Dimetotiazine.Approved
DiphenhydramineThe metabolism of Pseudoephedrine can be decreased when combined with Diphenhydramine.Approved
DiphenoxylatePseudoephedrine may increase the analgesic activities of Diphenoxylate.Approved, Illicit
DobutamineThe risk or severity of adverse effects can be increased when Dobutamine is combined with Pseudoephedrine.Approved
DopamineThe risk or severity of adverse effects can be increased when Dopamine is combined with Pseudoephedrine.Approved
DosulepinDosulepin may decrease the antihypertensive activities of Pseudoephedrine.Approved
DoxazosinDoxazosin may decrease the vasoconstricting activities of Pseudoephedrine.Approved
DoxepinDoxepin may decrease the antihypertensive activities of Pseudoephedrine.Approved
DoxofyllineThe risk or severity of adverse effects can be increased when Pseudoephedrine is combined with Doxofylline.Approved
DoxylaminePseudoephedrine may decrease the sedative activities of Doxylamine.Approved, Vet Approved
DronabinolDronabinol may increase the tachycardic activities of Pseudoephedrine.Approved, Illicit
DronedaroneThe metabolism of Pseudoephedrine can be decreased when combined with Dronedarone.Approved
DroperidolDroperidol may decrease the stimulatory activities of Pseudoephedrine.Approved, Vet Approved
DuloxetineDuloxetine may increase the tachycardic activities of Pseudoephedrine.Approved
EliglustatThe metabolism of Pseudoephedrine can be decreased when combined with Eliglustat.Approved
EmedastinePseudoephedrine may decrease the sedative activities of Emedastine.Approved
EphedrineThe risk or severity of adverse effects can be increased when Ephedrine is combined with Pseudoephedrine.Approved
EpinastinePseudoephedrine may decrease the sedative activities of Epinastine.Approved, Investigational
EpinephrineThe risk or severity of adverse effects can be increased when Epinephrine is combined with Pseudoephedrine.Approved, Vet Approved
Ergoloid mesylateErgoloid mesylate may increase the hypertensive activities of Pseudoephedrine.Approved
ErgonovineErgonovine may increase the hypertensive activities of Pseudoephedrine.Approved
ErgotamineErgotamine may increase the hypertensive activities of Pseudoephedrine.Approved
EsmirtazapineEsmirtazapine may decrease the antihypertensive activities of Pseudoephedrine.Investigational
EsmololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Esmolol.Approved
EthopropazinePseudoephedrine may decrease the sedative activities of Ethopropazine.Approved
EthosuximideThe therapeutic efficacy of Ethosuximide can be decreased when used in combination with Pseudoephedrine.Approved
EthoxzolamideEthoxzolamide may decrease the excretion rate of Pseudoephedrine which could result in a higher serum level.Withdrawn
EthylmorphinePseudoephedrine may increase the analgesic activities of Ethylmorphine.Approved, Illicit
EtilefrineThe risk or severity of adverse effects can be increased when Etilefrine is combined with Pseudoephedrine.Withdrawn
EtorphinePseudoephedrine may increase the analgesic activities of Etorphine.Illicit, Vet Approved
FamotidinePseudoephedrine may decrease the sedative activities of Famotidine.Approved
FencamfamineFencamfamine may decrease the stimulatory activities of Pseudoephedrine.Approved, Illicit, Withdrawn
FenoterolThe risk or severity of adverse effects can be increased when Fenoterol is combined with Pseudoephedrine.Approved
FentanylPseudoephedrine may increase the analgesic activities of Fentanyl.Approved, Illicit, Investigational, Vet Approved
FexofenadinePseudoephedrine may decrease the sedative activities of Fexofenadine.Approved
FlunarizinePseudoephedrine may decrease the sedative activities of Flunarizine.Approved
FluoxetineThe metabolism of Pseudoephedrine can be decreased when combined with Fluoxetine.Approved, Vet Approved
FlupentixolFlupentixol may decrease the stimulatory activities of Pseudoephedrine.Approved, Withdrawn
FluphenazineFluphenazine may decrease the stimulatory activities of Pseudoephedrine.Approved
FluspirileneFluspirilene may decrease the stimulatory activities of Pseudoephedrine.Approved
FluvoxamineThe metabolism of Pseudoephedrine can be decreased when combined with Fluvoxamine.Approved, Investigational
FurazolidoneFurazolidone may increase the hypertensive activities of Pseudoephedrine.Approved, Vet Approved
GuanethidineThe serum concentration of Pseudoephedrine can be decreased when it is combined with Guanethidine.Approved
HaloperidolThe metabolism of Pseudoephedrine can be decreased when combined with Haloperidol.Approved
HeroinPseudoephedrine may increase the analgesic activities of Heroin.Approved, Illicit
HexamethylenetetramineThe serum concentration of Pseudoephedrine can be decreased when it is combined with Hexamethylenetetramine.Approved, Vet Approved
HydracarbazineHydracarbazine may increase the hypertensive activities of Pseudoephedrine.Approved
HydrocodonePseudoephedrine may increase the analgesic activities of Hydrocodone.Approved, Illicit
HydromorphonePseudoephedrine may increase the analgesic activities of Hydromorphone.Approved, Illicit
HydroxyamphetamineThe risk or severity of adverse effects can be increased when Hydroxyamphetamine hydrobromide is combined with Pseudoephedrine.Approved
HydroxyzinePseudoephedrine may decrease the sedative activities of Hydroxyzine.Approved
IloperidoneIloperidone may decrease the stimulatory activities of Pseudoephedrine.Approved
ImipramineImipramine may decrease the antihypertensive activities of Pseudoephedrine.Approved
IndenololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Indenolol.Withdrawn
IndinavirThe metabolism of Pseudoephedrine can be decreased when combined with Indinavir.Approved
IndoraminIndoramin may decrease the vasoconstricting activities of Pseudoephedrine.Withdrawn
IobenguaneThe therapeutic efficacy of Iobenguane can be decreased when used in combination with Pseudoephedrine.Approved
Ioflupane I-123Pseudoephedrine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.Approved
IproclozideIproclozide may increase the hypertensive activities of Pseudoephedrine.Withdrawn
IproniazidIproniazid may increase the hypertensive activities of Pseudoephedrine.Withdrawn
IsocarboxazidIsocarboxazid may increase the hypertensive activities of Pseudoephedrine.Approved
IsoniazidThe metabolism of Pseudoephedrine can be decreased when combined with Isoniazid.Approved
IsoprenalineThe risk or severity of adverse effects can be increased when Isoprenaline is combined with Pseudoephedrine.Approved
IsothipendylPseudoephedrine may decrease the sedative activities of Isothipendyl.Approved
IsoxsuprineThe risk or severity of adverse effects can be increased when Isoxsuprine is combined with Pseudoephedrine.Approved, Withdrawn
KetobemidonePseudoephedrine may increase the analgesic activities of Ketobemidone.Approved
KetoconazoleThe metabolism of Pseudoephedrine can be decreased when combined with Ketoconazole.Approved, Investigational
KetotifenPseudoephedrine may decrease the sedative activities of Ketotifen.Approved
L-Glutamic AcidThe serum concentration of Pseudoephedrine can be decreased when it is combined with L-Glutamic Acid.Nutraceutical
LabetalolPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Labetalol.Approved
LevocabastinePseudoephedrine may decrease the sedative activities of Levocabastine.Approved
LevocetirizinePseudoephedrine may decrease the sedative activities of Levocetirizine.Approved
Levomethadyl AcetatePseudoephedrine may increase the analgesic activities of Levomethadyl Acetate.Approved
LevomilnacipranLevomilnacipran may increase the tachycardic activities of Pseudoephedrine.Approved
LevorphanolPseudoephedrine may increase the analgesic activities of Levorphanol.Approved
LinezolidLinezolid may increase the hypertensive activities of Pseudoephedrine.Approved, Investigational
LithiumLithium may decrease the stimulatory activities of Pseudoephedrine.Approved
LodoxamidePseudoephedrine may decrease the sedative activities of Lodoxamide.Approved
LofentanilPseudoephedrine may increase the analgesic activities of Lofentanil.Illicit
LopinavirThe metabolism of Pseudoephedrine can be decreased when combined with Lopinavir.Approved
LoratadinePseudoephedrine may decrease the sedative activities of Loratadine.Approved
LorcaserinThe metabolism of Pseudoephedrine can be decreased when combined with Lorcaserin.Approved
LoxapineLoxapine may decrease the stimulatory activities of Pseudoephedrine.Approved
LumefantrineThe metabolism of Pseudoephedrine can be decreased when combined with Lumefantrine.Approved
LurasidoneLurasidone may decrease the stimulatory activities of Pseudoephedrine.Approved
MagaldrateMagaldrate may decrease the excretion rate of Pseudoephedrine which could result in a higher serum level.Withdrawn
Magnesium carbonateMagnesium carbonate may decrease the excretion rate of Pseudoephedrine which could result in a higher serum level.Approved
Magnesium HydroxideMagnesium hydroxide may decrease the excretion rate of Pseudoephedrine which could result in a higher serum level.Approved
Magnesium oxideMagnesium oxide may decrease the excretion rate of Pseudoephedrine which could result in a higher serum level.Approved
Magnesium TrisilicateMagnesium Trisilicate may decrease the excretion rate of Pseudoephedrine which could result in a higher serum level.Approved
MebanazineMebanazine may increase the hypertensive activities of Pseudoephedrine.Withdrawn
MeclizinePseudoephedrine may decrease the sedative activities of Meclizine.Approved
MelperoneMelperone may decrease the stimulatory activities of Pseudoephedrine.Approved
MephentermineThe risk or severity of adverse effects can be increased when Mephentermine is combined with Pseudoephedrine.Approved
MepyraminePseudoephedrine may decrease the sedative activities of Mepyramine.Approved, Vet Approved
MequitazinePseudoephedrine may decrease the sedative activities of Mequitazine.Approved
MesoridazineMesoridazine may decrease the stimulatory activities of Pseudoephedrine.Approved
MetaraminolThe risk or severity of adverse effects can be increased when Metaraminol is combined with Pseudoephedrine.Approved, Investigational
MethadoneThe metabolism of Pseudoephedrine can be decreased when combined with Methadone.Approved
Methadyl AcetatePseudoephedrine may increase the analgesic activities of Methadyl Acetate.Approved, Illicit
MethamphetamineThe risk or severity of adverse effects can be increased when Methamphetamine is combined with Pseudoephedrine.Approved, Illicit
MethapyrilenePseudoephedrine may decrease the sedative activities of Methapyrilene.Withdrawn
MethazolamideMethazolamide may decrease the excretion rate of Pseudoephedrine which could result in a higher serum level.Approved
MethotrimeprazineThe metabolism of Pseudoephedrine can be decreased when combined with Methotrimeprazine.Approved
MethoxamineThe risk or severity of adverse effects can be increased when Methoxamine is combined with Pseudoephedrine.Approved
Methylene blueMethylene blue may increase the hypertensive activities of Pseudoephedrine.Investigational
MetiamidePseudoephedrine may decrease the sedative activities of Metiamide.Experimental
MetoprololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Metoprolol.Approved, Investigational
MianserinThe therapeutic efficacy of Pseudoephedrine can be decreased when used in combination with Mianserin.Approved
MidodrineThe risk or severity of adverse effects can be increased when Midodrine is combined with Pseudoephedrine.Approved
MilnacipranMilnacipran may increase the tachycardic activities of Pseudoephedrine.Approved
MinaprineMinaprine may increase the hypertensive activities of Pseudoephedrine.Approved
MirabegronThe metabolism of Pseudoephedrine can be decreased when combined with Mirabegron.Approved
MirtazapineMirtazapine may decrease the antihypertensive activities of Pseudoephedrine.Approved
MoclobemideMoclobemide may increase the hypertensive activities of Pseudoephedrine.Approved
MolindoneMolindone may decrease the stimulatory activities of Pseudoephedrine.Approved
MorphinePseudoephedrine may increase the analgesic activities of Morphine.Approved, Investigational
NabiloneNabilone may increase the tachycardic activities of Pseudoephedrine.Approved, Investigational
NadololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Nadolol.Approved
NalbuphinePseudoephedrine may increase the analgesic activities of Nalbuphine.Approved
NevirapineThe metabolism of Pseudoephedrine can be decreased when combined with Nevirapine.Approved
NialamideNialamide may increase the hypertensive activities of Pseudoephedrine.Withdrawn
NicardipineThe metabolism of Pseudoephedrine can be decreased when combined with Nicardipine.Approved
NilotinibThe metabolism of Pseudoephedrine can be decreased when combined with Nilotinib.Approved, Investigational
NizatidinePseudoephedrine may decrease the sedative activities of Nizatidine.Approved
NorepinephrineThe risk or severity of adverse effects can be increased when Norepinephrine is combined with Pseudoephedrine.Approved
NormethadonePseudoephedrine may increase the analgesic activities of Normethadone.Approved, Illicit
NortriptylineNortriptyline may decrease the antihypertensive activities of Pseudoephedrine.Approved
OctamoxinOctamoxin may increase the hypertensive activities of Pseudoephedrine.Withdrawn
OlanzapineOlanzapine may decrease the stimulatory activities of Pseudoephedrine.Approved, Investigational
OlopatadinePseudoephedrine may decrease the sedative activities of Olopatadine.Approved
OndansetronOndansetron may decrease the stimulatory activities of Pseudoephedrine.Approved
OpiumPseudoephedrine may increase the analgesic activities of Opium.Approved, Illicit
OrciprenalineThe risk or severity of adverse effects can be increased when Orciprenaline is combined with Pseudoephedrine.Approved
OsanetantOsanetant may decrease the stimulatory activities of Pseudoephedrine.Investigational
OxprenololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Oxprenolol.Approved
OxycodonePseudoephedrine may increase the analgesic activities of Oxycodone.Approved, Illicit, Investigational
OxymetazolineThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Pseudoephedrine.Approved
OxymorphonePseudoephedrine may increase the analgesic activities of Oxymorphone.Approved, Investigational, Vet Approved
PaliperidonePaliperidone may decrease the stimulatory activities of Pseudoephedrine.Approved
PanobinostatThe serum concentration of Pseudoephedrine can be increased when it is combined with Panobinostat.Approved, Investigational
PargylinePargyline may increase the hypertensive activities of Pseudoephedrine.Approved
ParoxetineThe metabolism of Pseudoephedrine can be decreased when combined with Paroxetine.Approved, Investigational
Peginterferon alfa-2bThe serum concentration of Pseudoephedrine can be decreased when it is combined with Peginterferon alfa-2b.Approved
PemirolastPseudoephedrine may decrease the sedative activities of Pemirolast.Approved
PenbutololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Penbutolol.Approved, Investigational
PentazocinePseudoephedrine may increase the analgesic activities of Pentazocine.Approved, Vet Approved
PerospironePerospirone may decrease the stimulatory activities of Pseudoephedrine.Approved
PerphenazinePerphenazine may decrease the stimulatory activities of Pseudoephedrine.Approved
PethidinePseudoephedrine may increase the analgesic activities of Pethidine.Approved
PhenelzinePhenelzine may increase the hypertensive activities of Pseudoephedrine.Approved
PhenindaminePseudoephedrine may decrease the sedative activities of Phenindamine.Approved
PheniprazinePheniprazine may increase the hypertensive activities of Pseudoephedrine.Withdrawn
PheniraminePseudoephedrine may decrease the sedative activities of Pheniramine.Approved
PhenmetrazineThe risk or severity of adverse effects can be increased when Phenmetrazine is combined with Pseudoephedrine.Approved, Illicit
PhenobarbitalThe serum concentration of Phenobarbital can be decreased when it is combined with Pseudoephedrine.Approved
PhenoxypropazinePhenoxypropazine may increase the hypertensive activities of Pseudoephedrine.Withdrawn
PhentermineThe risk or severity of adverse effects can be increased when Phentermine is combined with Pseudoephedrine.Approved, Illicit
PhenylephrineThe risk or severity of adverse effects can be increased when Phenylephrine is combined with Pseudoephedrine.Approved
PhenylpropanolamineThe risk or severity of adverse effects can be increased when Phenylpropanolamine is combined with Pseudoephedrine.Approved, Vet Approved, Withdrawn
PhenytoinThe serum concentration of Phenytoin can be decreased when it is combined with Pseudoephedrine.Approved, Vet Approved
PimozidePimozide may decrease the stimulatory activities of Pseudoephedrine.Approved
PindololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Pindolol.Approved
PipamperonePipamperone may decrease the stimulatory activities of Pseudoephedrine.Approved
PipotiazinePipotiazine may decrease the stimulatory activities of Pseudoephedrine.Approved
PirlindolePirlindole may increase the hypertensive activities of Pseudoephedrine.Approved
PivhydrazinePivhydrazine may increase the hypertensive activities of Pseudoephedrine.Withdrawn
PractololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Practolol.Approved
PrazosinPrazosin may decrease the vasoconstricting activities of Pseudoephedrine.Approved
ProcaterolThe risk or severity of adverse effects can be increased when Procaterol is combined with Pseudoephedrine.Approved
ProchlorperazineProchlorperazine may decrease the stimulatory activities of Pseudoephedrine.Approved, Vet Approved
PromazineThe metabolism of Pseudoephedrine can be decreased when combined with Promazine.Approved, Vet Approved
PromethazinePseudoephedrine may decrease the sedative activities of Promethazine.Approved
PropericiazinePropericiazine may decrease the stimulatory activities of Pseudoephedrine.Approved
PropranololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Propranolol.Approved, Investigational
ProtriptylineProtriptyline may decrease the antihypertensive activities of Pseudoephedrine.Approved
QuetiapineQuetiapine may decrease the stimulatory activities of Pseudoephedrine.Approved
QuinidineThe metabolism of Pseudoephedrine can be decreased when combined with Quinidine.Approved
QuinineThe metabolism of Pseudoephedrine can be decreased when combined with Quinine.Approved
RanitidinePseudoephedrine may decrease the sedative activities of Ranitidine.Approved
RanolazineThe metabolism of Pseudoephedrine can be decreased when combined with Ranolazine.Approved, Investigational
RasagilineRasagiline may increase the hypertensive activities of Pseudoephedrine.Approved
RemifentanilPseudoephedrine may increase the analgesic activities of Remifentanil.Approved
RemoxiprideRemoxipride may decrease the stimulatory activities of Pseudoephedrine.Approved, Withdrawn
ReserpineReserpine may decrease the stimulatory activities of Pseudoephedrine.Approved
RisperidoneRisperidone may decrease the stimulatory activities of Pseudoephedrine.Approved, Investigational
RitodrineThe risk or severity of adverse effects can be increased when Ritodrine is combined with Pseudoephedrine.Approved
RitonavirThe metabolism of Pseudoephedrine can be decreased when combined with Ritonavir.Approved, Investigational
RolapitantThe metabolism of Pseudoephedrine can be decreased when combined with Rolapitant.Approved
RopiniroleThe metabolism of Pseudoephedrine can be decreased when combined with Ropinirole.Approved, Investigational
Roxatidine acetatePseudoephedrine may decrease the sedative activities of Roxatidine acetate.Approved
SafrazineSafrazine may increase the hypertensive activities of Pseudoephedrine.Withdrawn
SelegilineSelegiline may increase the hypertensive activities of Pseudoephedrine.Approved, Investigational, Vet Approved
SertindoleSertindole may decrease the stimulatory activities of Pseudoephedrine.Approved, Withdrawn
SertralineThe metabolism of Pseudoephedrine can be decreased when combined with Sertraline.Approved
SilodosinSilodosin may decrease the vasoconstricting activities of Pseudoephedrine.Approved
SotalolPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Sotalol.Approved
Spaglumic AcidPseudoephedrine may decrease the sedative activities of Spaglumic Acid.Approved
SpironolactoneSpironolactone may decrease the vasoconstricting activities of Pseudoephedrine.Approved
StiripentolThe metabolism of Pseudoephedrine can be decreased when combined with Stiripentol.Approved
SufentanilPseudoephedrine may increase the analgesic activities of Sufentanil.Approved, Investigational
SulpirideSulpiride may decrease the stimulatory activities of Pseudoephedrine.Approved
SynephrineThe risk or severity of adverse effects can be increased when Synephrine is combined with Pseudoephedrine.Experimental
TamsulosinTamsulosin may decrease the vasoconstricting activities of Pseudoephedrine.Approved, Investigational
TapentadolPseudoephedrine may increase the analgesic activities of Tapentadol.Approved
Tedizolid PhosphateTedizolid Phosphate may increase the hypertensive activities of Pseudoephedrine.Approved
TerazosinTerazosin may decrease the vasoconstricting activities of Pseudoephedrine.Approved
TerbinafineThe metabolism of Pseudoephedrine can be decreased when combined with Terbinafine.Approved, Investigational, Vet Approved
TerbutalineThe risk or severity of adverse effects can be increased when Terbutaline is combined with Pseudoephedrine.Approved
TerfenadinePseudoephedrine may decrease the sedative activities of Terfenadine.Withdrawn
TesmilifenePseudoephedrine may decrease the sedative activities of Tesmilifene.Investigational
TetryzolineThe risk or severity of adverse effects can be increased when Tetryzoline is combined with Pseudoephedrine.Approved
ThioproperazineThioproperazine may decrease the stimulatory activities of Pseudoephedrine.Approved
ThioridazineThe metabolism of Pseudoephedrine can be decreased when combined with Thioridazine.Withdrawn
ThiothixeneThiothixene may decrease the stimulatory activities of Pseudoephedrine.Approved
TianeptineTianeptine may decrease the antihypertensive activities of Pseudoephedrine.Approved
TiaprideTiapride may decrease the stimulatory activities of Pseudoephedrine.Approved, Investigational
TiclopidineThe metabolism of Pseudoephedrine can be decreased when combined with Ticlopidine.Approved
TimololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Timolol.Approved
TipranavirThe metabolism of Pseudoephedrine can be decreased when combined with Tipranavir.Approved, Investigational
ToloxatoneToloxatone may increase the hypertensive activities of Pseudoephedrine.Approved
TramadolPseudoephedrine may increase the analgesic activities of Tramadol.Approved, Investigational
TranilastPseudoephedrine may decrease the sedative activities of Tranilast.Approved, Investigational
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the hypertensive activities of Pseudoephedrine.Experimental
TranylcypromineTranylcypromine may increase the hypertensive activities of Pseudoephedrine.Approved
TrifluoperazineTrifluoperazine may decrease the stimulatory activities of Pseudoephedrine.Approved
TriflupromazineTriflupromazine may decrease the stimulatory activities of Pseudoephedrine.Approved, Vet Approved
TrimazosinTrimazosin may decrease the vasoconstricting activities of Pseudoephedrine.Experimental
TrimipramineTrimipramine may decrease the antihypertensive activities of Pseudoephedrine.Approved
TripelennaminePseudoephedrine may decrease the sedative activities of Tripelennamine.Approved, Vet Approved
TriprolidinePseudoephedrine may decrease the sedative activities of Triprolidine.Approved
TyramineThe risk or severity of adverse effects can be increased when Tyramine is combined with Pseudoephedrine.Investigational, Nutraceutical
VenlafaxineVenlafaxine may increase the tachycardic activities of Pseudoephedrine.Approved
Vitamin CThe serum concentration of Pseudoephedrine can be decreased when it is combined with Vitamin C.Approved, Nutraceutical
ZiprasidoneThe metabolism of Pseudoephedrine can be decreased when combined with Ziprasidone.Approved
ZotepineZotepine may decrease the stimulatory activities of Pseudoephedrine.Approved
ZuclopenthixolZuclopenthixol may decrease the stimulatory activities of Pseudoephedrine.Approved, Investigational
Food Interactions
  • Take without regard to meals.
References
Synthesis Reference

Andrew G. Myers, “Synthesis of l-azatyrosine using pseudoephedrine as a chiral auxiliary.” U.S. Patent US5760237, issued June, 1991.

US5760237
General ReferencesNot Available
External Links
ATC CodesR01BA02R01BA52
AHFS Codes
  • 12:12.12
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (52.7 KB)
Clinical Trials
Clinical Trials
PhaseStatusPurposeConditionsCount
0RecruitingOtherMultiple System Atrophy (MSA) / Shy-Drager Syndrome1
1CompletedNot AvailableAutonomic Failure / Hypotension, Orthostatic1
1CompletedDiagnosticBMI >30 kg/m2 / Hypertensive / Pure Autonomic Failure / Shy-Drager Syndrome1
1CompletedTreatmentHealthy Volunteers5
2CompletedTreatmentAllergic Rhinitis (AR)3
2CompletedTreatmentSeasonal Allergic Rhinitis1
2Unknown StatusTreatmentRhinitis, Seasonal, Allergic1
2WithdrawnTreatmentHuman Immunodeficiency Virus (HIV) Infections / Sinusitis1
3CompletedTreatmentNasal Congestion Associated With the Common Cold1
3CompletedTreatmentNasal Congestion and Inflammations / Rhinitis1
3CompletedTreatmentPerennial Allergic Rhinitis (PAR)1
3CompletedTreatmentAcute Rhinitis / Pharyngitis1
3CompletedTreatmentRhinitis Seasonal1
3CompletedTreatmentRhinitis, Allergic, Perennial1
3CompletedTreatmentRhinitis, Allergic, Seasonal1
3CompletedTreatmentVasomotor Rhinitis1
3CompletedTreatmentAcute Rhinitis1
3Unknown StatusTreatmentViral Infections of the Upper Respiratory Tract1
3WithdrawnTreatmentCoughing / Inflammatory processes / Rhinitis1
4CompletedPreventionAcute Upper Respiratory Track Infection1
4CompletedTreatmentAcute Respiratory Infections / Acute Rhinosinusitis1
4CompletedTreatmentAcute bacterial rhinosinusitis / Acute Respiratory Infections / Bronchitis1
4CompletedTreatmentAcute Rhinitis / Headaches / Nasal Congestion1
4CompletedTreatmentNasal Congestion1
Not AvailableCompletedNot AvailableHealthy Volunteers2
Not AvailableCompletedNot AvailableSeasonal Allergic Rhinitis / Sinusitis1
Not AvailableCompletedBasic ScienceUrethral Sphincter Activity1
Not AvailableCompletedTreatmentAtopy / Rhinitis1
Not AvailableCompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Sinusitis1
Not AvailableCompletedTreatmentSeasonal Allergic Rhinitis1
Not AvailableRecruitingBasic ScienceMiddle Ear Disease / Nasal Allergies1
Not AvailableUnknown StatusTreatmentCoughing1
Not AvailableUnknown StatusTreatmentRhinitis / Sleep1
Pharmacoeconomics
Manufacturers
  • Ucb inc
  • Schering plough healthcare products inc
Packagers
Dosage forms
FormRouteStrength
Capsule, liquid filledOral
Tablet, film coatedOral
SyrupOral7.5 mg
SyrupOral
SolutionOral15 mg/5mL
Tablet, extended releaseOral
Tablet, multilayer, extended releaseOral
Capsule; kitOral
TabletOral30 mg
Capsule, extended releaseOral120 mg
PillOral30 mg/1
Kit; powder, for solutionOral
Tablet; tablet, extended releaseOral
Tablet, extended releaseOral120 mg
LiquidOral60 mg/60mL
Kit; powderOral
SuspensionOral
Tablet, sugar coatedOral
Tablet, film coated, extended releaseOral120 mg/1
PowderOral
SolutionOral
Tablet, coatedOral
Tablet, chewableOral
Tablet, film coated, extended releaseOral
TabletOral120 mg
Capsule, extended releaseOral240 mg
TabletOral
Capsule, gelatin coatedOral30 mg/1
TabletOral30 mg/1
Tablet, film coatedOral30 mg/1
Tablet, sugar coatedOral30 mg/1
LiquidOral
Capsule, extended releaseOral
Solution / dropsOral
Tablet, extended releaseOral120 mg/1
Tablet, film coatedOral120 mg/1
TabletOral60 mg/1
TabletOral60 mg
ElixirOral
Tablet, multilayerOral
CapsuleOral
LiquidOral30 mg/5mL
Kit; tabletOral
Tablet, extended releaseOral240 mg/1
TabletOral15 mg
SyrupOral30 mg
LiquidOral15 mg/5mL
Tablet, coatedOral30 mg/1
Tablet, film coatedOral60 mg/1
Powder, for solutionOral
LiquidOral30 mg
LiquidOral7.5 mg
Prices
Unit descriptionCostUnit
Sudafed 24 hour tablet0.84USD tablet
Pseudoephedrine hcl crystal0.67USD g
Afrin 0.05% nose spray0.62USD ml
Sudafed 12 hr sinus-pain caplet0.53USD caplet
Drixoral cold & allergy tablet sa0.4USD tablet
Sudafed om sinus nasal spray0.4USD ml
Afrin no drip sinus pump mist0.38USD ml
Sudafed pe cold & cough caplet0.34USD caplet
Afrin sinus spray0.33USD ml
Chlor-trimeton allergy0.31USD each
Sudafed pe severe cold caplet0.28USD caplet
Guaifenesin-phenylephrine tablet0.27USD tablet
Dimetapp cold-allergy tablet chew0.25USD tablet
Sudafed pe 10 mg tablet0.25USD tablet
Chlor-trimeton 8 mg repetab0.24USD tablet
Sudafed pe day & night tablet0.24USD tablet
Sudafed triple action caplet0.23USD caplet
Sudafed pe nighttime cold caplet0.22USD caplet
Sudafed non-drying sinus caplet0.2USD caplet
Sudafed pe sinus & allergy tablet0.2USD tablet
Sudafed pe sinus headache caplet0.2USD caplet
Sudafed 30 mg tablet0.19USD tablet
Wal-phed 30 mg tablet0.17USD tablet
Suphedrin 30 mg tablet0.15USD tablet
CVS Pharmacy decongestant 30 mg tablet0.12USD tablet
Sudogest 60 mg tablet0.12USD tablet
Medi-phedrine 30 mg tablet0.1USD tablet
Nasal decongestant 30 mg tablet0.1USD tablet
Genaphed plus tablet0.09USD tablet
CVS Pharmacy nasal decongest 30 mg tablet0.07USD tablet
Genaphed 30 mg tablet0.07USD tablet
Pseudoephedrine gg syrup0.07USD ml
Pseudoephedrine 60 mg tablet0.06USD tablet
Children's sudafed pe liquid0.05USD ml
Pseudoephedrine 30 mg tablet0.05USD tablet
Dimetapp cold & cough liquid0.04USD ml
Dimetapp dm cold & cough elix0.04USD ml
Dimetapp long-acting cough liquid0.04USD ml
Suphedrine 30 mg tablet0.04USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5855912 Yes1995-08-282015-08-28Us
US6037353 Yes1997-09-142017-09-14Us
US6039974 No1998-07-312018-07-31Us
US6100274 Yes2000-01-072020-01-07Us
US6113942 Yes1995-08-282015-08-28Us
US6211246 No1999-06-102019-06-10Us
US6372252 No2000-04-282020-04-28Us
US6469009 No1999-07-132019-07-13Us
US6489329 No1996-04-082016-04-08Us
US6613357 No2000-12-252020-12-25Us
US6709676 No2001-02-182021-02-18Us
US6955821 No2000-04-282020-04-28Us
US6979463 No2002-03-282022-03-28Us
US7014867 No2002-06-102022-06-10Us
US7226614 No2002-06-102022-06-10Us
US7618649 Yes2001-06-192021-06-19Us
US7820199 Yes2002-09-282022-09-28Us
US7838032 No2000-04-282020-04-28Us
US7863287 No2007-02-282027-02-28Us
US8187630 No2000-12-192020-12-19Us
USRE39069 No1998-05-292018-05-29Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point119 °CPhysProp
water solubility7 mg/LNot Available
logP0.89KRIL,MB & FUNG,HL (1990)
pKa10.3 (at 0 °C)PERRIN,DD (1965)
Predicted Properties
PropertyValueSource
Water Solubility8.26 mg/mLALOGPS
logP1ALOGPS
logP1.32ChemAxon
logS-1.3ALOGPS
pKa (Strongest Acidic)13.89ChemAxon
pKa (Strongest Basic)9.52ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area32.26 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity49.69 m3·mol-1ChemAxon
Polarizability18.83 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9645
Blood Brain Barrier+0.5638
Caco-2 permeable+0.8866
P-glycoprotein substrateNon-substrate0.7182
P-glycoprotein inhibitor INon-inhibitor0.9795
P-glycoprotein inhibitor IINon-inhibitor0.984
Renal organic cation transporterNon-inhibitor0.8965
CYP450 2C9 substrateNon-substrate0.8001
CYP450 2D6 substrateNon-substrate0.7839
CYP450 3A4 substrateNon-substrate0.7235
CYP450 1A2 substrateNon-inhibitor0.5595
CYP450 2C9 inhibitorNon-inhibitor0.7209
CYP450 2D6 inhibitorInhibitor0.5846
CYP450 2C19 inhibitorNon-inhibitor0.5737
CYP450 3A4 inhibitorNon-inhibitor0.9431
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.907
Ames testNon AMES toxic0.9517
CarcinogenicityNon-carcinogens0.7739
BiodegradationNot ready biodegradable0.7807
Rat acute toxicity2.3882 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9329
hERG inhibition (predictor II)Non-inhibitor0.9277
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Spectra
Mass Spec (NIST)Download (8.24 KB)
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, N/A (Annotated)splash10-016s-3900000000-868bf4bba93d8b4be696View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, N/A (Annotated)splash10-0159-2900000000-6c55fc67b7576cb42a8aView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, N/A (Annotated)splash10-0006-9700000000-459686cbaf7d3b59c202View in MoNA
MSMass Spectrum (Electron Ionization)splash10-0a4i-9000000000-8f0484f72b48017f1f2eView in MoNA
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
Taxonomy
DescriptionThis compound belongs to the class of chemical entities known as phenylpropanes. These are organic compounds containing a phenylpropane moiety.
KingdomChemical entities
Super ClassOrganic compounds
ClassBenzenoids
Sub ClassBenzene and substituted derivatives
Direct ParentPhenylpropanes
Alternative Parents
Substituents
  • Phenylpropane
  • Aralkylamine
  • 1,2-aminoalcohol
  • Secondary alcohol
  • Secondary aliphatic amine
  • Secondary amine
  • Alcohol
  • Organopnictogen compound
  • Organic oxygen compound
  • Organooxygen compound
  • Organonitrogen compound
  • Organic nitrogen compound
  • Amine
  • Aromatic alcohol
  • Hydrocarbon derivative
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Norepinephrine:sodium symporter activity
Specific Function:
Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name:
SLC6A2
Uniprot ID:
P23975
Molecular Weight:
69331.42 Da
References
  1. Wee S, Ordway GA, Woolverton WL: Reinforcing effect of pseudoephedrine isomers and the mechanism of action. Eur J Pharmacol. 2004 Jun 16;493(1-3):117-25. [PubMed:15189772 ]
  2. Foley KF, Van Dort ME, Sievert MK, Ruoho AE, Cozzi NV: Stereospecific inhibition of monoamine uptake transporters by meta-hydroxyephedrine isomers. J Neural Transm (Vienna). 2002 Oct;109(10):1229-40. [PubMed:12373557 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Monoamine transmembrane transporter activity
Specific Function:
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name:
SLC6A3
Uniprot ID:
Q01959
Molecular Weight:
68494.255 Da
References
  1. Wee S, Ordway GA, Woolverton WL: Reinforcing effect of pseudoephedrine isomers and the mechanism of action. Eur J Pharmacol. 2004 Jun 16;493(1-3):117-25. [PubMed:15189772 ]
  2. Foley KF, Van Dort ME, Sievert MK, Ruoho AE, Cozzi NV: Stereospecific inhibition of monoamine uptake transporters by meta-hydroxyephedrine isomers. J Neural Transm (Vienna). 2002 Oct;109(10):1229-40. [PubMed:12373557 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Protein heterodimerization activity
Specific Function:
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
Gene Name:
ADRA1A
Uniprot ID:
P35348
Molecular Weight:
51486.005 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Wellington K, Jarvis B: Cetirizine/pseudoephedrine. Drugs. 2001;61(15):2231-40; discussion 2241-2. [PubMed:11772135 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Thioesterase binding
Specific Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianser...
Gene Name:
ADRA2A
Uniprot ID:
P08913
Molecular Weight:
48956.275 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Serotonin:sodium symporter activity
Specific Function:
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin an...
Gene Name:
SLC6A4
Uniprot ID:
P31645
Molecular Weight:
70324.165 Da
References
  1. Wee S, Ordway GA, Woolverton WL: Reinforcing effect of pseudoephedrine isomers and the mechanism of action. Eur J Pharmacol. 2004 Jun 16;493(1-3):117-25. [PubMed:15189772 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
partial agonist
General Function:
Protein homodimerization activity
Specific Function:
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
Gene Name:
ADRB2
Uniprot ID:
P07550
Molecular Weight:
46458.32 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Vansal SS, Feller DR: Direct effects of ephedrine isomers on human beta-adrenergic receptor subtypes. Biochem Pharmacol. 1999 Sep 1;58(5):807-10. [PubMed:10449190 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonistpartial agonist
General Function:
Receptor signaling protein activity
Specific Function:
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.
Gene Name:
ADRB1
Uniprot ID:
P08588
Molecular Weight:
51322.1 Da
References
  1. Vansal SS, Feller DR: Direct effects of ephedrine isomers on human beta-adrenergic receptor subtypes. Biochem Pharmacol. 1999 Sep 1;58(5):807-10. [PubMed:10449190 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Transcriptional activator activity, rna polymerase ii distal enhancer sequence-specific binding
Specific Function:
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells.
Gene Name:
NFATC1
Uniprot ID:
O95644
Molecular Weight:
101241.73 Da
References
  1. Fiebich BL, Collado JA, Stratz C, Valina C, Hochholzer W, Munoz E, Bellido LM: Pseudoephedrine inhibits T-cell activation by targeting NF-kappaB, NFAT and AP-1 signaling pathways. Immunopharmacol Immunotoxicol. 2012 Feb;34(1):98-106. doi: 10.3109/08923973.2011.582118. Epub 2011 Jun 2. [PubMed:21631396 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Tumor necrosis factor receptor binding
Specific Function:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs ...
Gene Name:
TNF
Uniprot ID:
P01375
Molecular Weight:
25644.15 Da
References
  1. Wu Z, Kong X, Zhang T, Ye J, Fang Z, Yang X: Pseudoephedrine/ephedrine shows potent anti-inflammatory activity against TNF-alpha-mediated acute liver failure induced by lipopolysaccharide/D-galactosamine. Eur J Pharmacol. 2014 Feb 5;724:112-21. doi: 10.1016/j.ejphar.2013.11.032. Epub 2013 Dec 21. [PubMed:24365491 ]
  2. Fiebich BL, Collado JA, Stratz C, Valina C, Hochholzer W, Munoz E, Bellido LM: Pseudoephedrine inhibits T-cell activation by targeting NF-kappaB, NFAT and AP-1 signaling pathways. Immunopharmacol Immunotoxicol. 2012 Feb;34(1):98-106. doi: 10.3109/08923973.2011.582118. Epub 2011 Jun 2. [PubMed:21631396 ]
10. Nuclear factor kappa-light-chain-enhancer of activated B cells
Kind
Protein
Organism
Human
Pharmacological action
unknown
References
  1. Fiebich BL, Collado JA, Stratz C, Valina C, Hochholzer W, Munoz E, Bellido LM: Pseudoephedrine inhibits T-cell activation by targeting NF-kappaB, NFAT and AP-1 signaling pathways. Immunopharmacol Immunotoxicol. 2012 Feb;34(1):98-106. doi: 10.3109/08923973.2011.582118. Epub 2011 Jun 2. [PubMed:21631396 ]
Kind
Protein group
Organism
Human
Pharmacological action
unknown
General Function:
Transcriptional activator activity, rna polymerase ii transcription regulatory region sequence-specific binding
Specific Function:
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.
Components:
NameUniProt IDDetails
Cyclic AMP-dependent transcription factor ATF-1P18846 Details
Cyclic AMP-dependent transcription factor ATF-2P15336 Details
Cyclic AMP-dependent transcription factor ATF-3P18847 Details
Cyclic AMP-dependent transcription factor ATF-4P18848 Details
Cyclic AMP-dependent transcription factor ATF-5Q9Y2D1 Details
Cyclic AMP-dependent transcription factor ATF-6 alphaP18850 Details
Cyclic AMP-dependent transcription factor ATF-7P17544 Details
Jun dimerization protein 2Q8WYK2 Details
Proto-oncogene c-FosP01100 Details
Transcription factor AP-1P05412 Details
References
  1. Fiebich BL, Collado JA, Stratz C, Valina C, Hochholzer W, Munoz E, Bellido LM: Pseudoephedrine inhibits T-cell activation by targeting NF-kappaB, NFAT and AP-1 signaling pathways. Immunopharmacol Immunotoxicol. 2012 Feb;34(1):98-106. doi: 10.3109/08923973.2011.582118. Epub 2011 Jun 2. [PubMed:21631396 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Kinase activator activity
Specific Function:
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
Gene Name:
IL2
Uniprot ID:
P60568
Molecular Weight:
17627.52 Da
References
  1. Fiebich BL, Collado JA, Stratz C, Valina C, Hochholzer W, Munoz E, Bellido LM: Pseudoephedrine inhibits T-cell activation by targeting NF-kappaB, NFAT and AP-1 signaling pathways. Immunopharmacol Immunotoxicol. 2012 Feb;34(1):98-106. doi: 10.3109/08923973.2011.582118. Epub 2011 Jun 2. [PubMed:21631396 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Serotonin binding
Specific Function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.
Gene Name:
MAOA
Uniprot ID:
P21397
Molecular Weight:
59681.27 Da
References
  1. Ulus IH, Maher TJ, Wurtman RJ: Characterization of phentermine and related compounds as monoamine oxidase (MAO) inhibitors. Biochem Pharmacol. 2000 Jun 15;59(12):1611-21. [PubMed:10799660 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Comments
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Drug created on June 13, 2005 07:24 / Updated on April 29, 2017 08:03