Pseudoephedrine

Identification

Name
Pseudoephedrine
Accession Number
DB00852  (APRD00634)
Type
Small Molecule
Groups
Approved
Description

An alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used in the treatment of several disorders including asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.

Structure
Thumb
Synonyms
  • (+) threo-2-(methylamino)-1-phenyl-1-propanol
  • (+)-(1S,2S)-Pseudoephedrine
  • (+)-Pseudoephedrine
  • (+)-psi-Ephedrine
  • (+)-threo-Ephedrine
  • d-Isoephedrine
  • d-Pseudoephedrine
  • d-psi-2-Methylamino-1-phenyl-1-propanol
  • d-psi-Ephedrine
  • Isoephedrine
  • L-(+)-Pseudoephedrine
  • L(+)-psi-Ephedrine
  • Pseudoefedrina
  • pseudoéphédrine
  • Pseudoephedrine D-form
  • Pseudoephedrinum
  • Psi-ephedrin
  • Psi-ephedrine
  • trans-Ephedrine
  • ψ-ephedrine
External IDs
Not Available
Product Ingredients
IngredientUNIICASInChI Key
Pseudoephedrine hydrochloride6V9V2RYJ8N 345-78-8BALXUFOVQVENIU-KXNXZCPBSA-N
Pseudoephedrine sulfateY9DL7QPE6B 7460-12-0XVPDSDYVNYOVMP-KXNXZCPBSA-N
Product Images
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
SudoGestTablet, film coated60 mg/1Oralbryant ranch prepack1994-10-01Not applicableUs
Approved Generic Prescription Products
Not Available
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
12 Hour DecongestantTablet, film coated, extended release120 mg/1OralKroger1999-12-14Not applicableUs
12 Hour DecongestantTablet, film coated, extended release120 mg/1OralL. Perrigo Company2011-10-04Not applicableUs
12 Hour DecongestantTablet, film coated, extended release120 mg/1OralMeijer Distribution1999-11-05Not applicableUs
12 Hour Nasal DecongestantTablet, film coated, extended release120 mg/1OralCvs Health1999-12-01Not applicableUs
12 Hour Nasal Decongestant Non DrowsyTablet, film coated, extended release120 mg/1OralSafeway2000-05-25Not applicableUs
Balminil Decongestionnant Sirop 30mg/5mlSyrup30 mgOralRougier Pharma Division Of Ratiopharm Inc1988-12-312000-09-07Canada
Benylin D for InfantsSyrup7.5 mgOralPfizer Canada Inc., Consumer Healthcare Division2004-08-092006-08-03Canada
Care One Suphedrine Nasal Decongestant Non DrowsyTablet, film coated30 mg/1OralAmerican Sales Company2003-12-01Not applicableUs
CareOne Nasal and Sinus DecongestantTablet, film coated, extended release120 mg/1OralAmerican Sales Company2016-09-15Not applicableUs
Careone Suphedrine 12 Hour Relief Non DrowsyTablet, film coated, extended release120 mg/1OralAmerican Sales Company2004-05-11Not applicableUs
Childrens SilfedrineLiquid15 mg/5mLOralSilarx Pharmaceuticals, Inc.2001-01-05Not applicableUs
Childrens Sudafed Nasal DecongestantSolution15 mg/5mLOralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2008-10-01Not applicableUs
Childrens Uniphed Nasal DecongestantLiquid15 mg/5mLOralRij Pharmaceutical Corporation1999-03-16Not applicableUs
Congest Aid Tab 30mgTablet30 mgOralZee Medical Inc1990-12-312009-07-30Canada
Congest-eze Tab 60mgTablet60 mgOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1996-10-182002-07-31Canada
Contac Cold Nondrowsy CapsulesCapsule, extended release120 mgOralSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.1997-07-072001-07-31Canada
Contac-C Nondrowsy (sustained Release Cap)Capsule, extended release120 mgOralSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.1994-12-311997-08-15Canada
CVS Health Non-Drowsy Nasal DecongestantPill30 mg/1OralWestport Pharmaceuticals2015-10-05Not applicableUs
CVS Health Non-Drowsy Nasal DecongestantPill30 mg/1OralWestport Pharmaceuticals2015-10-05Not applicableUs
CVS Health Non-Drowsy Nasal DecongestantPill30 mg/1OralWestport Pharmaceuticals2015-10-05Not applicableUs
Decongestant TabletsTablet60 mgOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1996-12-312002-07-31Canada
Eltor 120 Srt 120mgTablet, extended release120 mgOralMerrell Dow Pharmaceuticals (Canada) Inc.1992-12-311996-08-29Canada
Ephed 60Liquid60 mg/60mLOralDickey Consumer Products DBA DMD2011-10-10Not applicableUs
Equaline 12 Hour DecongestantTablet, film coated, extended release120 mg/1OralSupervalu2004-08-10Not applicableUs
Equaline Nasal Decongestant Non Drowsy Maximum StrengthTablet, film coated30 mg/1OralSupervalu2004-08-17Not applicableUs
Equate SuphedrineTablet, film coated, extended release120 mg/1OralWalmart Stores2000-07-19Not applicableUs
Good Neighbor Pharmacy Nasal DecongestantTablet, film coated30 mg/1OralAmerisource Bergen1989-08-15Not applicableUs
Good Neighbor Pharmacy Nasal DecongestantTablet, film coated, extended release120 mg/1OralAmerisource Bergen1999-08-12Not applicableUs
Good Sense Nasal DecongestantTablet, film coated30 mg/1OralL. Perrigo Company1989-09-15Not applicableUs
Good Sense Suphedrine 12 HourTablet, film coated, extended release120 mg/1OralL. Perrigo Company1999-10-29Not applicableUs
Harris Teeter SinusTablet, film coated30 mg/1OralHarris Teeter2015-06-23Not applicableUs
Harris Teeter Sinus 12 HourTablet, film coated, extended release120 mg/1OralHarris Teeter2015-06-23Not applicableUs
Health Mart nasal decongestantTablet, film coated, extended release120 mg/1OralMc Kesson2012-01-11Not applicableUs
Health Mart Nasal DecongestantTablet, film coated30 mg/1OralMc Kesson2011-12-23Not applicableUs
Healthy Accents 12 Hour Nasal Decongestant maximum strengthTablet, film coated, extended release120 mg/1OralDza Brands,2011-07-19Not applicableUs
Healthy Accents Nasal DecongestantTablet, film coated30 mg/1OralDza Brands,2011-06-23Not applicableUs
Leader 12 Hour Nasal DecongestantTablet, film coated, extended release120 mg/1OralCardinal Health1999-07-21Not applicableUs
Leader Nasal Decongestant Maximum StrengthTablet, film coated30 mg/1OralCardinal Health1990-06-15Not applicableUs
Maxenal Caplet 120mgTablet120 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1992-12-312000-07-24Canada
Maxenal Src 240mgCapsule, extended release240 mgOralKv Pharmaceutical Company1992-12-312002-04-29Canada
Members Mark Nasal Decongestant Maximum StrengthTablet, film coated30 mg/1OralSam's West, Inc1999-02-03Not applicableUs
Nasal DecongestantTablet, film coated30 mg/1OralShopko Stores Operating2013-09-07Not applicableUs
Nasal DecongestantTablet, film coated, extended release120 mg/1OralPublix Supermarkets, Inc.2000-03-20Not applicableUs
Nasal DecongestantTablet, sugar coated30 mg/1OralRugby2011-09-22Not applicableUs
Nasal DecongestantTablet, film coated30 mg/1OralH.E.B.1981-08-25Not applicableUs
Nasal DecongestantTablet, film coated, extended release120 mg/1OralHyvee2000-09-11Not applicableUs
Nasal DecongestantCapsule, gelatin coated30 mg/1OralCvs Health2017-02-09Not applicableUs
Nasal DecongestantTablet, sugar coated30 mg/1Oralbryant ranch prepack2011-09-22Not applicableUs
Nasal DecongestantTablet, film coated30 mg/1OralKroger1987-07-15Not applicableUs
Nasal DecongestantTablet, film coated, extended release120 mg/1OralShopko Stores Operating2014-03-10Not applicableUs
Nasal DecongestantTablet30 mg/1OralRugby2012-10-29Not applicableUs
Nasal DecongestantTablet30 mg/1OralProficient Rx LP2012-10-29Not applicableUs
Nasal DecongestantTablet, film coated30 mg/1OralPublix Supermarkets, Inc.1993-09-09Not applicableUs
Nasal DecongestantTablet, film coated30 mg/1OralLnk International, Inc.1981-08-25Not applicableUs50844 0112 22 nlmimage10 04390268
Nasal DecongestantTablet, film coated30 mg/1OralL. Perrigo Company1987-07-15Not applicableUs
Nasal DecongestantTablet, film coated, extended release120 mg/1OralRebel Distributors1999-08-12Not applicableUs
Nasal DecongestantTablet, film coated30 mg/1OralCvs Health1987-07-15Not applicableUs
Nasal Decongestant Maximum StrengthTablet30 mg/1OralSunmark (Mckesson)1981-08-25Not applicableUs
Nasal Decongestant Maximum StrengthTablet, film coated30 mg/1OralBetter Living Brands1981-08-25Not applicableUs
Nasal Decongestant Maximum StrengthTablet30 mg/1OralCardinal Health1981-08-25Not applicableUs
Nasal Decongestant Maximum StrengthTablet, film coated30 mg/1OralChain Drug Consortium1981-08-25Not applicableUs
Nasal Decongestant Maximum StrengthTablet30 mg/1OralSupervalu1981-08-25Not applicableUs
Nasal Decongestant Maximum StrengthTablet30 mg/1OralChain Drug Marketing Association1981-08-25Not applicableUs
Nasal Decongestant Maximum Strength Non DrowsyTablet, film coated30 mg/1OralMeijer Distribution1991-02-15Not applicableUs
Nasal Decongestant Maximum Strength Non DrowsyTablet, film coated30 mg/1OralHannaford Brothers Company1995-07-05Not applicableUs
Nasal Decongestant Maximum Strength Non DrowsyTablet, film coated30 mg/1OralSafeway1987-07-15Not applicableUs
Nasal Decongestant Maximum Strength, Non-DrowsyTablet, film coated30 mg/1OralAmerisource Bergen1981-08-25Not applicableUs
Nasal Decongestant Non DrowsyTablet, film coated30 mg/1OralHyvee1989-01-15Not applicableUs
Nasal Decongestant Non-drowsyTablet, film coated30 mg/1OralMc Kesson (Health Mart)1981-08-25Not applicableUs
Nasal Decongestant Non-DrowsyTablet, film coated30 mg/1OralCvs Health1981-08-25Not applicableUs
NexafedTablet30 mg/1OralAcura Pharmaceuticals, Inc.2012-12-10Not applicableUs
Non Drowsy Regular Strength Contac Cold 12 HourTablet, extended release120 mgOralGlaxosmithkline Inc1999-08-162009-07-28Canada
Plus SinusTablet, extended release120 mgOralPfizer Canada Inc., Consumer Healthcare Division1999-02-112000-08-03Canada
Preferred Plus SinusTablet, film coated30 mg/1OralKinray2014-06-09Not applicableUs
Pseudo-timeTablet, coated30 mg/1OralTime Cap Laboratories2012-05-01Not applicableUs
Pseudoephedrine HClTablet, extended release120 mg/1OralAurohealth LLC2017-06-09Not applicableUs
Pseudoephedrine HydrochlorideTablet, film coated, extended release120 mg/1OralAmerisource Bergen2006-04-28Not applicableUs
Pseudoephedrine HydrochlorideTablet, film coated, extended release120 mg/1OralH.E.B.2006-04-28Not applicableUs
Pseudoephedrine hydrochlorideTablet, film coated120 mg/1OralOhm Laboratories, Inc.2006-04-28Not applicableUs
Pseudoephedrine HydrochlorideTablet, film coated, extended release120 mg/1OralMeijer Distribution2006-04-28Not applicableUs
Pseudoephedrine HydrochlorideTablet, film coated30 mg/1OralPerrigo New York Inc.2008-10-17Not applicableUs
Pseudoephedrine HydrochlorideTablet, film coated, extended release120 mg/1OralCvs Health2006-04-28Not applicableUs
Pseudoephedrine HydrochlorideTablet, film coated, extended release120 mg/1OralChain Drug Consortium2006-04-28Not applicableUs
Pseudoephedrine HydrochlorideTablet, film coated, extended release120 mg/1OralPerrigo New York Inc.2014-05-24Not applicableUs
Pseudoephedrine HydrochlorideTablet, film coated, extended release120 mg/1OralChain Drug Marketing Association2006-04-28Not applicableUs
Pseudoephedrine HydrochlorideTablet, film coated, extended release120 mg/1OralRemedy Repack2015-10-19Not applicableUs
Pseudoephedrine HydrochlorideTablet, film coated, extended release120 mg/1OralSafeway2006-04-28Not applicableUs
Pseudoephedrine HydrochlorideTablet, film coated, extended release120 mg/1OralPublix Supermarkets, Inc.2006-04-28Not applicableUs
Pseudoephedrine hydrochlorideTablet, extended release120 mg/1OralOhm Laboratories, Inc.2006-04-28Not applicableUs
Pseudoephedrine HydrochlorideTablet, extended release120 mg/1OralCardinal Health2017-02-15Not applicableUs
Pseudoephedrine HydrochlorideTablet, extended release120 mg/1OralMc Kesson2017-02-20Not applicableUs
Pseudoephedrine HydrochlorideTablet, film coated60 mg/1OralPhysicians Total Care, Inc.2002-11-25Not applicableUs
Pseudoephedrine HydrochlorideTablet, coated30 mg/1OralAAA Pharmaceutical, Inc.2012-12-22Not applicableUs
Pseudoephedrine HydrochlorideTablet, film coated, extended release120 mg/1OralShopko Stores Operating2006-04-28Not applicableUs
Pseudoephedrine HydrochlorideTablet, film coated, extended release120 mg/1OralWalgreen2006-04-28Not applicableUs
Pseudoephedrine Hydrochloride Srt 120mg TabTablet, extended release120 mgOralKv Pharmaceutical Company1990-05-042002-04-29Canada
Pseudoephedrine Non drowsy formulaTablet30 mg/1OralContract Pharmacal Corporation2001-06-21Not applicableUs
Pseudoephedrine Non-drowsy formulaTablet60 mg/1OralContract Pharmacal Corporation2001-07-17Not applicableUs
Pulmosirum 5 Tab 60mgTablet60 mgOralNutribon (1986) Inc.1992-12-311996-09-30Canada
Robidrine Tab 60mgTablet60 mgOralWhitehall Robins Inc.1993-12-312000-07-26Canada
Rugby Nasal DecongestantLiquid30 mg/5mLOralA S Medication Solutions1999-07-262017-06-20Us
Rugby Nasal DecongestantLiquid30 mg/5mLOralRugby1999-07-26Not applicableUs
Rugby Nasal DecongestantLiquid30 mg/5mLOralbryant ranch prepack1999-07-26Not applicableUs
Rugby Nasal Decongestant Nasal DecongestantLiquid30 mg/5mLOralDispensing Solutions, Inc.1999-07-26Not applicableUs
Rx Act Nasal DecongestantTablet, film coated30 mg/1OralH.E.B.2006-02-13Not applicableUs
ShopRite Nasal DecongestantTablet, film coated30 mg/1OralWakfern Food Corporation2013-09-17Not applicableUs
ShopRite Nasal DecongestantTablet, film coated, extended release120 mg/1OralWakfern Food Corporation2014-03-25Not applicableUs
Sinus CongestionTablet, film coated30 mg/1OralL. Perrigo Company2016-10-04Not applicableUs
Sinus Pressure and Congestion Relief Maximum StrengthTablet30 mg/1OralRite Aid1981-08-25Not applicableUs
Sinus Pressure and Congestion Relief Maximum StrengthTablet, film coated, extended release120 mg/1OralRite Aid1999-08-30Not applicableUs
Smart Sense 12 Hour DecongestantTablet, film coated, extended release120 mg/1OralKmart Corporation2011-03-14Not applicableUs
Smart Sense Nasal DecongestantTablet, film coated, extended release120 mg/1OralKmart Corporation2014-02-18Not applicableUs
Smart Sense Nasal DecongestantTablet, film coated30 mg/1OralKmart Corporation2011-03-14Not applicableUs
Smart Sense SinusTablet, film coated30 mg/1OralKmart Corporation2015-08-27Not applicableUs
Smart Sense Sinus 12 HourTablet, film coated, extended release120 mg/1OralKmart Corporation2015-08-17Not applicableUs
SudafedTablet, coated30 mg/1OralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2011-10-01Not applicableUs
Sudafed 12 HourTablet, film coated, extended release120 mg/1OralA S Medication Solutions2008-06-012017-06-20Us
Sudafed 12 HourTablet, film coated, extended release120 mg/1OralA S Medication Solutions2008-06-012017-06-20Us
Sudafed 12 HourTablet, film coated, extended release120 mg/1OralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2008-06-01Not applicableUs
Sudafed 12 HourTablet, film coated, extended release120 mg/1OralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2017-09-01Not applicableUs
Sudafed 24 HourTablet, extended release240 mg/1OralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2008-10-01Not applicableUs
Sudafed Decongestant 12 Hour Caplets - 120mgTablet120 mgOralWarner Lambert Canada Inc.1996-10-111999-08-13Canada
Sudafed Decongestant Children's Chewable TabletsTablet15 mgOralPfizer Canada Inc., Consumer Healthcare Division1998-08-132006-08-03Canada
Sudafed Decongestant Extra Strength TabletTablet60 mgOralPfizer Canada Inc., Consumer Healthcare Division1998-11-302006-08-03Canada
Sudafed Decongestant Extra Strength TabletsTablet60 mgOralWarner Lambert Canada Inc.1996-10-111999-08-13Canada
Sudafed Decongestant Regular Strength SyrupSyrup30 mgOralWarner Lambert Canada Inc.1998-11-302000-08-01Canada
Sudafed Decongestant Regular Strength SyrupSyrup30 mgOralWarner Lambert Canada Inc.1996-10-111999-08-13Canada
Sudafed Decongestant Regular Strength TabletTablet30 mgOralWarner Lambert Canada Inc.1996-10-111999-08-13Canada
Sudafed Decongestant Regular Strength TabletTablet30 mgOralWarner Lambert Canada Inc.1998-11-302000-08-01Canada
Sudafed Nasal Cold 12 Hour CapletsTablet120 mgOralGlaxo Wellcome1995-12-312000-08-03Canada
Sudafed Nasal Cold Extra Strength TabletsTablet60 mgOralGlaxo Wellcome1995-12-312000-08-03Canada
Sudafed Nasal Cold Regular Strength SyrupSyrup30 mgOralGlaxo Wellcome1995-12-312000-08-03Canada
Sudafed Nasal Cold Regular Strength TabsTablet30 mgOralGlaxo Wellcome1995-12-312000-08-03Canada
Sudafed Syr 30mg/5mlSyrup30 mgOralBurroughs Wellcome1958-12-312000-08-02Canada
Sudafed Tab 60mgTablet60 mgOralBurroughs Wellcome1958-12-312000-08-02Canada
Sudodrin Tab 60mgTablet60 mgOralIcn Pharmaceuticals1979-12-311998-08-13Canada
SudoGestTablet, film coated30 mg/1OralMajor1981-08-25Not applicableUs
SudoGestTablet, film coated60 mg/1OralRebel Distributors1994-10-01Not applicableUs
SudoGestTablet, film coated, extended release120 mg/1OralRemedy Repack2015-12-15Not applicableUs
SudoGestTablet, film coated60 mg/1OralProficient Rx LP1994-10-01Not applicableUs
SudoGestTablet30 mg/1OralA S Medication Solutions1981-08-252017-06-20Us
SudoGestTablet, film coated30 mg/1OralRemedy Repack2017-01-13Not applicableUs
SudoGestTablet, film coated60 mg/1OralA S Medication Solutions1994-10-012017-06-20Us
SudoGestTablet, film coated30 mg/1OralA S Medication Solutions1981-08-252017-06-20Us
SudoGestTablet, film coated60 mg/1OralUnit Dose Services1984-12-07Not applicableUs
SudoGestTablet, coated30 mg/1OralMajor2014-02-17Not applicableUs
SudoGestTablet30 mg/1OralRebel Distributors1994-10-01Not applicableUs
SudoGestTablet30 mg/1OralA S Medication Solutions1981-08-252017-06-20Us
SudoGestTablet, film coated60 mg/1OralMajor1984-12-07Not applicableUs
SudoGestTablet, coated30 mg/1OralA S Medication Solutions2014-02-172017-06-20Us
SudoGestLiquid15 mg/5mLOralMajor2001-01-05Not applicableUs
SudoGestTablet, film coated60 mg/1OralRemedy Repack2013-06-272017-12-02Us
SudoGestTablet, film coated30 mg/1OralRemedy Repack2012-12-14Not applicableUs
SudoGestTablet, film coated60 mg/1OralA S Medication Solutions1994-10-012017-06-20Us
SudoGestTablet, film coated60 mg/1OralRemedy Repack2017-01-13Not applicableUs
SudoGestTablet, film coated30 mg/1OralA S Medication Solutions1981-08-252017-06-20Us
SudoGestTablet, film coated, extended release120 mg/1OralMajor2006-04-28Not applicableUs
SudoGestTablet30 mg/1OralRemedy Repack2007-04-172017-03-10Us
SudoGestTablet, film coated60 mg/1OralAidarex Pharmaceuticals LLC1994-10-01Not applicableUs
SudoGestTablet, coated30 mg/1OralA S Medication Solutions2014-02-172017-06-20Us
SudoGestTablet60 mg/1OralDispensing Solutions, Inc.1994-10-01Not applicableUs
SudoGestTablet, film coated60 mg/1OralH.J. Harkins Company1994-10-01Not applicableUs
SudoGest Nasal DecongestantTablet, film coated30 mg/1OralMajor1991-09-10Not applicableUs
Sunmark Nasal DecongestantTablet, film coated30 mg/1OralMc Kesson2003-08-15Not applicableUs
Sunmark Sinus 12 hourTablet, film coated, extended release120 mg/1OralMc Kesson2003-06-24Not applicableUs
SuphedrineTablet, film coated30 mg/1OralWalmart Stores1981-08-252017-03-13Us
SuphedrineTablet, film coated, extended release120 mg/1OralRite Aid2002-08-13Not applicableUs
Suphedrine Maximum StrengthTablet, film coated30 mg/1OralChain Drug Marketing Association1981-08-25Not applicableUs
Topcare 12 Hour DecongestantTablet, film coated, extended release120 mg/1OralTopco Associates2000-04-25Not applicableUs
Topcare Nasal Decongestant Maximum Strength Non DrowsyTablet, film coated30 mg/1OralTopco Associates1988-01-15Not applicableUs
Triaminic Allergy CongestionLiquid30 mgOralNovartis2001-07-162006-07-04Canada
Triaminic Pediatric Oral Cold Drops - 7.5mg/0.8mlLiquid7.5 mgOralNovartis1995-12-312008-07-15Canada
Up and Up 12 Hour Nasal DecongestantTablet, film coated, extended release120 mg/1OralTarget Corporation.2009-09-02Not applicableUs
UP AND UP nasal decongestantTablet, film coated30 mg/1OralTarget Corporation.2009-08-04Not applicableUs
Up and Up Sinus 12 HourTablet, film coated, extended release120 mg/1OralTarget Corporation.2015-03-13Not applicableUs
Up and Up SuphedrineTablet, film coated30 mg/1OralTarget Corporation.2015-03-13Not applicableUs
Wal PhedTablet, film coated, extended release120 mg/1OralWalgreen1999-09-24Not applicableUs
Wal-phedTablet, film coated30 mg/1OralWalgreen1981-08-25Not applicableUs
Walphed D Maximum Strength Non Drowsy SinusTablet, film coated, extended release120 mg/1OralWalgreen1999-09-24Not applicableUs
Zephrex DCapsule, gelatin coated30 mg/1OralL. Perrigo Company2016-11-04Not applicableUs
Zephrex-DTablet30 mg/1OralWestport Pharmaceuticals2012-11-15Not applicableUs
Unapproved/Other Products
Not Available
International/Other Brands
Afrinol / Benylin Decongestant / Cenafed / Decofed / Dimetapp Decongestant / Eltor 120 / Genaphed / Maxenal / Myfedrine / Novafed / Robidrine / Sudafed Decongestant
Brand mixtures
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
12 Hour Allergy DTablet, extended releaseOralMeijer Distribution1988-07-15Not applicableUs
A.M. Cold Relief FormulaCapsuleOralIvax Pharmaceuticals IncorporatedNot applicableNot applicableCanada
Abanatuss PedSolutionOralKramer Novis.2015-07-01Not applicableUs
Abanatuss Ped DropsSolutionOralKramer Novis.2015-08-05Not applicableUs
Abatuss DmxLiquidOralKramer Novis.2014-05-25Not applicableUs
Acetaminophen/dextromethorphan/pseudoephedrineCapsuleOralApotex CorporationNot applicableNot applicableCanada
Acetaminophen/pseudoephedrine/dextromethorphan/doxylamineCapsuleOralApotex CorporationNot applicableNot applicableCanada
ActiconTabletOralActipharma, Inc2015-08-13Not applicableUs
Actifed DM SyrupSyrupOralGlaxo Wellcome1980-12-312000-08-03Canada
Actifed DM TabletsTabletOralGlaxo Wellcome1994-12-312000-08-03Canada
Actifed Plus CapletTabletOralGlaxo Wellcome1991-12-312000-08-03Canada
Actifed Plus CapletsTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2000-04-142016-01-22Canada
Actifed SyrupLiquidOralGlaxo Wellcome1960-12-312000-08-03Canada
Actifed TabletsTabletOralGlaxo Wellcome1960-12-312000-08-03Canada
ActinelSolutionOralActipharma, Inc2014-09-24Not applicableUs
Actinel PediatricSolutionOralActipharma, Inc2014-09-24Not applicableUs
Advil Allergy SinusTablet, coatedOralPfizer2002-12-20Not applicableUs
Advil Cold & Sinus Convenience PackKit; TabletOralPfizer Laboratories Div Pfizer Inc.2014-11-27Not applicableCanada
Advil Cold & Sinus Liqui-gelsCapsuleOralPfizer Laboratories Div Pfizer Inc.2005-07-09Not applicableCanada
Advil Cold and SinusTabletOralPfizer Laboratories Div Pfizer Inc.1993-12-31Not applicableCanada
Advil Cold and Sinus DaytimeTabletOralPfizer Laboratories Div Pfizer Inc.2006-08-07Not applicableCanada
Advil Cold and Sinus NighttimeTabletOralPfizer Laboratories Div Pfizer Inc.2006-08-04Not applicableCanada
Advil Cold and Sinus PlusTabletOralPfizer Laboratories Div Pfizer Inc.2004-08-02Not applicableCanada
Aerius Dual Action 12 HourTablet, extended releaseOralBayer Inc Consumer Care2010-02-01Not applicableCanada
Aerius Dual Action 24 HourTablet, multilayer, extended releaseOralBayer Inc Consumer CareNot applicableNot applicableCanada
Alavert Allergy Sinus D-12Tablet, film coated, extended releaseOralWyeth Ltd.2004-01-30Not applicableUs00573 2660 24 nlmimage10 8d46c6b6
Alka-Seltzer Plus-D Multi-Symptom Sinus and ColdCapsule, liquid filledOralBayer Health Care Llc, Consumer Care2013-08-012017-08-19Us
All day Allergy dTablet, extended releaseOralMajor2008-05-06Not applicableUs
all day Allergy Relief DTablet, extended releaseOralH.E.B.2008-05-02Not applicableUs
All Day Allergy-DTablet, extended releaseOralL. Perrigo Company2011-09-06Not applicableUs
All Day Sinus and Cold DTablet, film coatedOralHyvee2013-08-12Not applicableUs
Allegra D 12 Hour Allergy and CongestionTablet, film coated, extended releaseOralRebel Distributors2011-03-03Not applicableUs
Allegra D-12 HourTablet, extended releaseOralSanofi Aventis1997-12-24Not applicableUs00088 1090 47 nlmimage10 d503eadf
Allegra--D 24 HourTablet, film coatedOralSanofi Aventis2004-10-19Not applicableUs
Allegra-DTablet, extended releaseOralbryant ranch prepack2009-03-04Not applicableUs
Allegra-D 24 HourTablet, film coatedOralStat Rx USA2004-10-19Not applicableUs
Allegra-D Allergy and CongestionTablet, film coated, extended releaseOralA S Medication Solutions2011-03-032017-06-20Us
Allerclear-D 24 HourTablet, extended releaseOralCostco Wholesale2016-03-01Not applicableUs
Allergy + Sinus Relief Extra Strength TabletsTabletOralPharmetics (2011) Inc.2004-08-17Not applicableCanada
Allergy + Sinus Relief Regular CapletsTabletOralPharmetics (2011) Inc.Not applicableNot applicableCanada
Allergy and Congestion ReliefTablet, extended releaseOralL. Perrigo Company2012-01-23Not applicableUs
Allergy and Congestion Relief D Original Prescription StrengthTablet, extended releaseOralRite Aid2008-04-10Not applicableUs
Allergy and Congestion Relief Non DrowsyTablet, film coatedOralAmerisource Bergen2010-11-13Not applicableUs
Allergy Relief DTablet, extended releaseOralShopko Stores Operating2013-10-02Not applicableUs
Allergy Relief d 12Tablet, extended releaseOralCvs Health2012-01-25Not applicableUs
Allergy Relief D 12 HourTablet, extended releaseOralPublix Supermarkets, Inc.2013-05-09Not applicableUs
Allergy Relief D 24 HourTablet, extended releaseOralPublix Supermarkets, Inc.2003-06-25Not applicableUs
Allergy Relief-DTablet, film coated, extended releaseOralCvs Health2014-02-07Not applicableUs
Allergy Relief-D 24 HourTablet, extended releaseOralShopko Stores Operating2016-03-01Not applicableUs
Allergy Relief-D24 Hour 24 HourTablet, extended releaseOralTopco Associates2016-03-21Not applicableUs
Allergy Sinus Headache CapletsTabletOralTanta Pharmaceuticals Inc2002-01-04Not applicableCanada
Allergy Sinus Medication - CapletTabletOralWestcan Pharmaceuticals Ltd.1996-10-112002-07-31Canada
Allergy Sinus Nighttime ReliefTabletOralVita Health Products Inc2012-01-12Not applicableCanada
Allergy, Sinus and Headache Relief MedicationTabletOralPharmetics (2011) Inc.Not applicableNot applicableCanada
Allpanto STabletOralSAMSUNG PHARM IND. CO., LTD.2012-03-012017-04-14Us
AprodineTablet, film coatedOralRebel Distributors1993-01-09Not applicableUs
Atuss DaLiquidOralAber Pharmaceuticals, Llc2016-02-082017-02-14Us
Atuss DS Tannate SuspensionSuspensionOralAtley Pharmaceuticals2006-11-212017-08-29Us
Balminil Codeine + Decongestant + ExpectorantLiquidOralRougier Pharma Division Of Ratiopharm Inc2001-12-132015-10-01Canada
Balminil Cough and FluSyrupOralRougier Pharma Division Of Ratiopharm Inc2001-03-202015-10-01Canada
Balminil DM + DecongestantSyrupOralRougier Pharma Division Of Ratiopharm Inc1995-12-312015-10-01Canada
Balminil DM + Decongestant + ExpectorantSyrupOralTeva1998-05-22Not applicableCanada
Balminil DM + Decongestant + Expectorant Extra StrengthSyrupOralTeva1998-04-22Not applicableCanada
Balminil DM-D-E - LiqLiquidOralRougier Pharma Division Of Ratiopharm Inc1997-01-242009-08-04Canada
Benadryl Allergy & Cold CapletsTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Benadryl Allergy Sinus CapletsTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1997-03-032016-01-22Canada
Benadryl Decongestant TabletsTabletOralWarner Lambert Canada Inc.1987-12-311997-08-26Canada
Benadryl TotalTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2004-10-15Not applicableCanada
Benylin 2 Cold and Flu With CodeineSyrupOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2003-07-112015-08-06Canada
Benylin 4 Flu - SyrupSyrupOralPfizer Canada Inc., Consumer Healthcare Division1996-12-312003-07-03Canada
Benylin A-D Extra Strength CapletsTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Benylin A-D Regular Strength CapletsTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Benylin A-D-AH Extra Strength CapletsTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Benylin A-D-AH Regular Strength CapletsTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Benylin All-IN-one Cold and Flu Extra StrengthTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1997-08-06Not applicableCanada
Benylin All-IN-one Cold and Flu Extra Strength SyrupSyrupOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2003-07-03Not applicableCanada
Benylin All-IN-one Cold and Flu Liquid GelsCapsuleOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2010-08-11Not applicableCanada
Benylin All-IN-one Cold and Flu Night Extra StrengthTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2005-09-23Not applicableCanada
Benylin All-IN-one Cold and Flu Night Extra Strength SyrupSyrupOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2005-09-23Not applicableCanada
Benylin Codeine 3.3mg De SyrSyrupOralPfizer Canada Inc., Consumer Healthcare Division1992-12-312003-07-11Canada
Benylin Cough and Chest Congestion Extra Strength With Warming SensationSyrupOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1992-12-31Not applicableCanada
Benylin Cough and ColdSyrupOralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Benylin Cough Plus Cold ReliefSyrupOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1992-12-31Not applicableCanada
Benylin D-AH for ChildrenSyrupOralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Benylin DM-DSyrupOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1992-12-312016-08-05Canada
Benylin DM-D Chewables for ChildrenTablet, chewableOralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Benylin DM-D for ChildrenSyrupOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1992-12-31Not applicableCanada
Benylin DM-D for InfantsSyrupOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2004-08-092007-11-05Canada
Benylin DM-D-AH Chewables for ChildrenTablet, chewableOralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Benylin DM-D-AH for ChildrenSyrupOralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Benylin DM-D-E-A Cold and Sinus Liquid GelsCapsuleOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1995-12-312016-01-22Canada
Benylin Extra Strength All-IN-one Cold and Flu With Warming SensationSyrupOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2009-08-06Not applicableCanada
Benylin Extra Strength Cough Plus Cold ReliefSyrupOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2005-09-30Not applicableCanada
Benylin Extra Strength Mucus & Phlegm Plus Cold ReliefTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2010-08-11Not applicableCanada
Benylin Extra Strength Mucus & Phlegm Plus Cold Relief NightSyrupOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2011-08-08Not applicableCanada
Benylin for Children All-IN-one Cold & FeverSuspensionOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2008-09-01Not applicableCanada
Benylin for Children All-IN-one Cold and FeverTablet, chewableOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2010-09-072016-01-22Canada
Benylin for Children Cough Stuffy and Runny NoseSyrupOralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
BIO Dtuss DMXLiquidOralAdvanced Generic Corporation2011-12-01Not applicableUs
Bio-cnexLiquidOralAdvanced Generic Corporation2017-01-01Not applicableUs
BionelLiquidOralAdvanced Generic Corporation2009-10-01Not applicableUs
Bionel PediatricLiquidOralAdvanced Generic Corporation2009-10-01Not applicableUs
Bromfed DMSyrupOralClinical Solutions Wholsesale2009-08-212017-06-27Us
BromfedDM DMSyrupOralPhysicians Total Care, Inc.2012-10-26Not applicableUs
Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan HydrobromideSyrupOralPaddock Laboratories, Inc.2015-02-06Not applicableUs
Brompheniramine Maleate, Pseudoephedrine Hydrochloride and DextromethorphanHydrobromideSyrupOralProficient Rx LP2010-06-15Not applicableUs
Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan HydrobromideSyrupOralMorton Grove Pharmaceuticals, Inc.2010-06-15Not applicableUs
Brompheniramine Maleate, Pseudoephedrine Hydrochloride, Dextromethorphan HydrobromideSyrupOralAcella Pharmaceuticals, LLC2016-09-21Not applicableUs
Bronchodex PediatriqueSyrupOralTherapex Division De E Z Em Canada Inc1983-12-311997-07-22Canada
BrotappLiquidOralSilarx Pharmaceuticals, Inc.2001-04-05Not applicableUs
Brotapp DM Cold and CoughLiquidOralSilarx Pharmaceuticals, Inc.2001-04-05Not applicableUs
BroveX PSBLiquidOralMcr American Pharmaceuticals, Inc.2007-11-30Not applicableUs
BroveX PSB DMLiquidOralMcr American Pharmaceuticals, Inc.2007-11-30Not applicableUs
Buckley's Cold & Sinus DayTabletOralThe Buckley's CompanyNot applicableNot applicableCanada
Buckley's Cold & Sinus NightTabletOralThe Buckley's CompanyNot applicableNot applicableCanada
Buckley's Complete Daytime Plus Mucus Relief SoftgelsCapsuleOralThe Buckley's Company2010-08-02Not applicableCanada
Buckley's Complete Daytime SoftgelsCapsuleOralThe Buckley's CompanyNot applicableNot applicableCanada
Buckley's Complete Extra Strength Cough, Cold & Flu DayTabletOralThe Buckley's Company2000-08-08Not applicableCanada
Buckley's Complete Extra Strength Cough, Cold and Flu NightTabletOralThe Buckley's Company2000-08-08Not applicableCanada
Buckley's Complete Nighttime SoftgelsCapsuleOralThe Buckley's Company2010-08-02Not applicableCanada
Buckley's Daytime Cold and SinusCapsuleOralThe Buckley's Company2008-07-21Not applicableCanada
Buckley's DM DecongestantLiquidOralThe Buckley's Company1994-12-312016-08-02Canada
Buckley's Nighttime Cold and SinusCapsuleOralThe Buckley's Company2008-07-21Not applicableCanada
Buckley's Sinus Pain Relief Extra Strength TabletsTabletOralThe Buckley's Company2001-10-122008-07-15Canada
Calmylin #2 SyrSyrupOralTechnilab Pharma Inc.1992-12-312003-09-24Canada
Calmylin #3 SyrSyrupOralTechnilab Pharma Inc.1992-12-312003-09-24Canada
Calmylin Codeine D-E SyrSyrupOralTechnilab Pharma Inc.1993-12-311997-08-22Canada
Calmylin Cough and Flu LiqLiquidOralTechnilab Pharma Inc.1992-12-312003-09-24Canada
Calmylin Pediatric SyrupSyrupOralTechnilab Pharma Inc.1989-12-312003-09-24Canada
Calmylin Pse With CodeineLiquidOralTeva1996-08-30Not applicableCanada
Capmist DMTabletOralCapital Pharmaceutical2013-06-20Not applicableUs
Care One Ibuprofen Cold and SinusTablet, sugar coatedOralAmerican Sales Company2004-05-11Not applicableUs
CareOne All Day Allergy DTablet, extended releaseOralAmerican Sales Company2008-05-12Not applicableUs
CareOne Allergy and congestion reliefTablet, extended releaseOralAmerican Sales Company2012-08-21Not applicableUs
CareOne Allergy Relief DTablet, extended releaseOralAmerican Sales Company2016-07-20Not applicableUs
Centracol Pediatrique - SyrSyrupOralPrometic Pharma Inc.1994-12-311999-08-12Canada
Cetiri DTablet, extended releaseOralRite Aid2008-04-10Not applicableUs
Cetirizine HCl and Pseudoephedrine HCl ERTablet, film coated, extended releaseOralPhysicians Total Care, Inc.2008-03-31Not applicableUs
Cetirizine Hydrochloride and Pseudoephedrine HydrochlorideTablet, film coated, extended releaseOralSun Pharmaceutical Industries Limited2012-09-29Not applicableUs
Cheratussin DACLiquidOralQualitest1997-01-01Not applicableUs
Children's Advil ColdSuspensionOralPfizer Laboratories Div Pfizer Inc.2004-08-09Not applicableCanada
Children's Advil Cold & Flu Multi-symptomSuspensionOralPfizer Laboratories Div Pfizer Inc.2010-01-26Not applicableCanada
Children's Allergy and Sinus Medication Liquid SuspensionSuspensionOralPharmetics (2011) Inc.Not applicableNot applicableCanada
Children's Benadryl-D Allergy & SinusLiquidOralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Children's Cough & Cold ReliefSyrupOralTrillium Health Care Products Inc2013-08-29Not applicableCanada
Children's Motrin ColdSuspensionOralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Children's Nicold MedicineLiquidOralTanta Pharmaceuticals IncNot applicableNot applicableCanada
Children's Nyquil LiquidLiquidOralProcter And Gamble1993-12-312006-07-25Canada
Children's Sinus Medication Liquid SuspensionSuspensionOralPharmetics (2011) Inc.Not applicableNot applicableCanada
Children's Tussin Cough Medicine DM Antitussive DecongestantLiquidOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1998-01-132002-07-31Canada
Children's Tylenol Allergy - D Chewable TabletsTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2000-03-152002-07-19Canada
Children's Tylenol Allergy-D SuspensionSuspensionOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2000-06-152005-07-22Canada
Children's Tylenol Cold & Stuffy NoseSuspensionOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1997-10-08Not applicableCanada
Children's Tylenol Cold and CoughSuspensionOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1997-08-12Not applicableCanada
Children's Tylenol Cold Chewable TabletsTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1987-12-312016-01-22Canada
Children's Tylenol Cold LiquidLiquidOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1987-12-311998-08-10Canada
Children's Tylenol Cold Liquid With DMLiquidOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1990-12-311998-08-10Canada
Children's Tylenol Cold SuspensionSuspensionOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1997-08-11Not applicableCanada
Children's Tylenol Complete Cold, Cough & FeverSuspensionOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2012-08-31Not applicableCanada
Children's Tylenol Decongestant - TabTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Children's Tylenol Sinus Chewable TabletTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2000-03-152002-07-19Canada
Children's Tylenol Sinus SuspensionSuspensionOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2000-03-142008-08-07Canada
Childrens Advil ColdSuspensionOralPfizer2002-04-182016-11-18Us
Chlo TussLiquidOralR. A. Mc Neil Company2013-10-01Not applicableUs
Chlor-tripolon Decon Ext Str Repetabs 12Tablet, extended releaseOralSchering Plough1983-12-312006-08-01Canada
Chlor-tripolon Nd SrtTablet, extended releaseOralSchering Plough1992-12-312012-07-24Canada
Clarinex-D 12 HourTablet, extended releaseOralMerck Sharp & Dohme Limited2006-02-01Not applicableUs00085 1322 01 nlmimage10 cf07e78f
Claritin Allergy + SinusTablet, multilayer, extended releaseOralBayer Inc Consumer Care1991-12-31Not applicableCanada
Claritin Allergy + Sinus Extra StrengthTablet, extended releaseOralBayer Inc Consumer Care2005-03-01Not applicableCanada
Claritin-D 12 HourTablet, extended releaseOralBayer Health Care Llc.2009-12-01Not applicableUs
Claritin-D 24 HourTablet, extended releaseOralMsd Consumer Care Inc.2009-12-012017-07-19Us
CloferaLiquidOralCentrix Pharmaceutical2009-08-142016-10-21Us
CoactifedSyrupOralGlaxosmithkline Inc1960-12-31Not applicableCanada
Codar DLiquidOralRespa Pharmaceuticals2011-07-13Not applicableUs
Coditussin DACSyrupOralGlendale Inc2016-05-01Not applicableUs
Cold & CoughCapsuleOralStrides Pharma IncNot applicableNot applicableCanada
Cold & Cough Extra StrengthCapsuleOralStrides Pharma IncNot applicableNot applicableCanada
Cold & FluCapsuleOralStrides Pharma IncNot applicableNot applicableCanada
Cold & Flu DaytimeLiquidOralArrow Otc Company2007-12-072011-08-03Canada
Cold & Flu NighttimeLiquidOralArrow Otc Company2007-12-072011-08-03Canada
Cold & Flu-IN-oneKit; TabletOralVita Health Products Inc2012-04-25Not applicableCanada
Cold & Sinus Liquid CapsulesCapsule; KitOralVita Health Products Inc2016-06-01Not applicableCanada
Cold & Sinus Liquid FastgelsCapsuleOralVita Health Products Inc2009-01-22Not applicableCanada
Cold & Sinus Relief CapsulesCapsuleOralApotex Corporation2014-03-20Not applicableCanada
Cold + SinusTabletOralVita Health Products Inc2010-10-12Not applicableCanada
Cold + Sinus CapletsTabletOralVita Health Products Inc2006-12-08Not applicableCanada
Cold + Sinus DaytimeTabletOralVita Health Products IncNot applicableNot applicableCanada
Cold + Sinus Daytime Cold + Sinus NighttimeKit; TabletOralVita Health Products Inc2014-05-23Not applicableCanada
Cold + Sinus NighttimeTabletOralVita Health Products Inc2015-01-01Not applicableCanada
Cold + Sinus PlusTabletOralVita Health Products Inc2011-04-19Not applicableCanada
Cold and Cough Relief Extra StrengthTabletOralPharmetics (2011) Inc.Not applicableNot applicableCanada
Cold and Flu CapsulesCapsuleOralVita Health Products Inc2003-06-04Not applicableCanada
Cold and Flu Extra Strength DayTabletOralPharmetics (2011) Inc.Not applicableNot applicableCanada
Cold and Flu Medicine - Day Time FormulaCapsuleOralPharmetics (2011) Inc.2006-04-102010-07-12Canada
Cold and Flu Medicine - Night Time FormulaCapsuleOralPharmetics (2011) Inc.2006-04-102010-07-12Canada
Cold and Flu Nighttime DSolutionOralWalgreen2014-02-05Not applicableUs
Cold and Flu Nighttime Relief Syrup Extra StrengthSyrupOralPharmetics (2011) Inc.Not applicableNot applicableCanada
Cold and Flu-IN-one Extra StrengthTabletOralVita Health Products Inc2007-04-01Not applicableCanada
Cold and Flu-IN-one Regular StrengthTabletOralVita Health Products IncNot applicableNot applicableCanada
Cold and Nasal Congestion Relief Nighttime Extra StrengthTabletOralPharmetics (2011) Inc.Not applicableNot applicableCanada
Cold and Nasal Congestion Relief Super StrengthTabletOralPharmetics (2011) Inc.Not applicableNot applicableCanada
Cold and Sinus Complete Liquid GelsCapsuleOralVita Health Products Inc2016-06-01Not applicableCanada
Cold and Sinus Daytime ReliefTabletOralVita Health Products Inc2014-07-15Not applicableCanada
Cold and Sinus Nighttime ReliefTabletOralVita Health Products IncNot applicableNot applicableCanada
Cold and Sinus Pain ReliefTablet, sugar coatedOralSafeway2001-10-30Not applicableUs
Cold and Sinus PlusTabletOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Cold and Sinus ReliefTablet, sugar coatedOralCvs Health2001-10-09Not applicableUs
Cold and Sinus Relief ComboKit; TabletOralVita Health Products Inc2013-06-24Not applicableCanada
Cold Flu ReliefLiquidOralPerrigo International1997-01-09Not applicableCanada
Cold MedicationKit; TabletOralVita Health Products Inc2012-06-28Not applicableCanada
Cold Medication Extra Strength DaytimeTabletOralPharmascience Inc1996-09-192016-10-28Canada
Cold Medication Extra Strength Night TimeTabletOralPharmascience Inc1996-09-192016-10-28Canada
Cold Medication Reg Strength D TabTabletOralProdemdis Enr.1996-09-192010-07-15Canada
Cold Medication Reg Strength N TabTabletOralProdemdis Enr.1996-09-192010-07-15Canada
Cold Medication Regular Nighttime TabletsTabletOralPharmetics (2011) Inc.Not applicableNot applicableCanada
Cold Relief Daytime TabletTabletOralJamp Pharma Corporation2004-06-29Not applicableCanada
Cold Relief Duo PackKit; TabletOralPharmetics (2011) Inc.Not applicableNot applicableCanada
Cold Relief Nightime TabletTabletOralJamp Pharma Corporation2004-06-29Not applicableCanada
Cold,sore Throat Pain & Cough Ultra StrengthPowder, for solutionOralThe Winning Combination Inc.Not applicableNot applicableCanada
Cold/flu ReliefLiquidOralPerrigo International2002-02-202005-05-09Canada
CompleteKit; TabletOralVita Health Products Inc2015-05-01Not applicableCanada
Complete DaytimeTabletOralVita Health Products IncNot applicableNot applicableCanada
Complete Daytime Liquid CapsulesCapsuleOralVita Health Products Inc2015-05-01Not applicableCanada
Complete Liquid CapsulesCapsule; KitOralVita Health Products Inc2012-12-10Not applicableCanada
Complete Liquid Capsules Nighttime ReliefCapsuleOralVita Health Products Inc2017-05-25Not applicableCanada
Complete One Cold and Flu Extra StrengthSolutionOralTanta Pharmaceuticals IncNot applicableNot applicableCanada
Complete One Cold and Flu Extra Strength TabletsTabletOralTanta Pharmaceuticals IncNot applicableNot applicableCanada
Complete One Cold and Flu Nightime Extra Strength LiquidLiquidOralTanta Pharmaceuticals IncNot applicableNot applicableCanada
Complete One Cold and Flu Nightime Extra Strength TabletsTabletOralTanta Pharmaceuticals IncNot applicableNot applicableCanada
ConexTabletOralLlorens Pharmaceuticals International Division2007-11-01Not applicableUs
CongestacTablet, film coatedOralBF ASCHER AND CO INC2014-09-19Not applicableUs
Contac Cold and Fever CapletsTabletOralGlaxosmithkline Inc2000-12-012008-08-01Canada
Contac Cold and Sore Throat CapletsTabletOralGlaxosmithkline Inc2000-12-012008-08-01Canada
Contac Cold Nasal Congestion-nighttimeTabletOralGlaxosmithkline Inc2004-06-302008-08-01Canada
Contac Cold Nasal Congestion-non Drowsy Regular StrengthTabletOralGlaxosmithkline Inc2004-12-162008-08-01Canada
Contac Complete Cough, Cold & Flu SyrupSyrupOralGlaxosmithkline Inc2005-07-032009-05-06Canada
Contac Cough & Cold SyrupSyrupOralGlaxosmithkline Inc2005-07-032008-08-01Canada
Contac Day & Night Sinus/allergy CapletTabletOralSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.1994-12-311996-09-13Canada
Contac Extend-C Sustained Release CapsulesCapsule, extended releaseOralGlaxosmithkline IncNot applicableNot applicableCanada
Contac Night CapletsTabletOralGlaxosmithkline Inc1999-05-132008-08-01Canada
Contac-C Ext.stren.night Time Cough,cold&fluTabletOralSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.1996-12-311997-08-15Canada
CopantoTabletOralSAMSUNG PHARM IND. CO., LTD.2012-03-012017-04-14Us
Coricidin 'd' Nasal and Sinus CongestionTablet, extended releaseOralSchering Plough Healthcare Products Canada, A Division Of Schering Canada Inc.Not applicableNot applicableCanada
Coricidin D Flu, Nasal and SinusTabletOralSchering Plough Healthcare Products Canada, A Division Of Schering Canada Inc.Not applicableNot applicableCanada
Coricidin D Nasal and Sinus Congestion TabletsTablet, extended releaseOralSchering Plough Healthcare Products Canada, A Division Of Schering Canada Inc.Not applicableNot applicableCanada
CotrifedLiquidOralTechnilab Pharma Inc.1989-12-311997-08-22Canada
Cough & ColdSyrupOralPharmetics (2011) Inc.2006-10-19Not applicableCanada
Cough & Cold ReliefSyrupOralTrillium Health Care Products Inc2013-08-29Not applicableCanada
Cough & Cold Relief Extra StrengthSyrupOralTrillium Health Care Products Inc2013-07-30Not applicableCanada
Cough & Cold Soft Gel CapsCapsuleOralApotex Inc., Private Label DivisionNot applicableNot applicableCanada
Cough and Flu SyrupSyrupOralTechnilab Pharma Inc.1995-12-312005-08-07Canada
Cough Plus Cold Relief SyrupSyrupOralPharmetics (2011) Inc.2006-11-13Not applicableCanada
Cough Syr W.cod. Pseudoephed.hcl GuaifenesinSyrupOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1994-12-312002-07-31Canada
Cough Syrup DM - Decongestant - ExpectorantSyrupOralJamp Pharma Corporation2002-12-31Not applicableCanada
Cough Syrup DM - Decongestant - Expectorant Extra StrengthSyrupOralJamp Pharma Corporation2002-12-31Not applicableCanada
Cough Syrup DM - Decongestant for ChildrenSyrupOralJamp Pharma Corporation2002-12-31Not applicableCanada
Cough Syrup DM DecongestantSyrupOralJamp Pharma Corporation2002-12-31Not applicableCanada
Cough Syrup DM Decongestant ExpectorantSyrupOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1994-12-312002-07-31Canada
Cough Syrup DM Decongestant for ChildrenSyrupOralKsl Pharmaceuticals1994-12-311999-08-12Canada
Cough Syrup DM-D-ESyrupOralWestcan Pharmaceuticals Ltd.1995-12-311996-09-09Canada
Cough Syrup DM-D-E With AcetaminophenSyrupOralSupplements Aromatik Inc.Not applicableNot applicableCanada
Cough Syrup DM-D-E With Acetaminophen Extra StrengthSyrupOralSupplements Aromatik Inc.Not applicableNot applicableCanada
Cough Syrup With CodeineSyrupOralTeva1995-12-31Not applicableCanada
Cough, Cold & FluKit; TabletOralVita Health Products Inc2012-09-13Not applicableCanada
Cough, Cold & Flu Super StrengthPowder, for solutionOralThe Winning Combination Inc.Not applicableNot applicableCanada
Cough, Cold and Flu Daytime CapletsTabletOralVita Health Products Inc2003-11-26Not applicableCanada
Cough, Cold and Flu Nightime CapletsTabletOralVita Health Products Inc2003-11-21Not applicableCanada
Cough, Cold and Flu Relief Complete Night Super StrengthTabletOralPharmetics (2011) Inc.Not applicableNot applicableCanada
Cough, Cold and Flu Relief Day Super StrengthTabletOralPharmetics (2011) Inc.Not applicableNot applicableCanada
Covan SyrupSyrupOralPharmascience Inc2000-12-11Not applicableCanada
Day & Night Combo PackKit; Powder, for solutionOralThe Winning Combination Inc.Not applicableNot applicableCanada
Day Relief Cold and Flu Liquid CapsulesCapsuleOralBanner Pharmacaps2005-05-172009-08-07Canada
Day Time Liquid CapsCapsuleOralIvax Pharmaceuticals IncorporatedNot applicableNot applicableCanada
Day Time Multi Symptom ReliefCapsuleOralStrides Pharma IncNot applicableNot applicableCanada
Day Time ReliefCapsuleOralStrides Pharma IncNot applicableNot applicableCanada
Day Time Relief Extra StrengthCapsuleOralStrides Pharma IncNot applicableNot applicableCanada
Daycap Cold & Sinus Liquid GelsCapsuleOralAccucaps Industries LimitedNot applicableNot applicableCanada
Dayquil DLiquidOralProcter And Gamble2004-02-01Not applicableCanada
Dayquil LiquicapsCapsuleOralProcter And Gamble1993-12-311997-10-31Canada
Dayquil Liquicaps - CapCapsuleOralProcter And Gamble1997-03-102005-07-28Canada
Dayquil Medicine - LiqLiquidOralProcter And Gamble2000-08-012004-12-16Canada
Daytime 325 Liqua CapsCapsuleOralJamp Pharma CorporationNot applicableNot applicableCanada
Daytime Cold & Flu Liquid CapsulesCapsuleOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1996-12-311999-09-17Canada
Daytime Cold and Flu Liquid CapsulesCapsuleOralBanner Pharmacaps2003-09-102006-07-10Canada
Daytime Cold and Flu ReliefCapsuleOralPharmetics (2011) Inc.2005-09-13Not applicableCanada
Daytime Cold Medication Liquid FastgelsCapsuleOralVita Health Products Inc2011-03-24Not applicableCanada
Daytime Cold Relief CapletsTabletOralPharmetics (2011) Inc.Not applicableNot applicableCanada
Daytime Cold Relief Extra Strength TabletsTabletOralPharmetics (2011) Inc.2004-08-20Not applicableCanada
Daytime Cold/flu ReliefLiquidOralPerrigo International2005-05-092008-08-06Canada
Daytime Cough. Cold. Flu Gel CapsulesCapsuleOralApotex Inc., Private Label DivisionNot applicableNot applicableCanada
Daytime Flu Relief Extra StrengthTabletOralPharmetics (2011) Inc.Not applicableNot applicableCanada
Daytime Liqua CapsCapsuleOralJamp Pharma Corporation2005-03-15Not applicableCanada
Daytime Liquid - LiqLiquidOralPerrigo International1998-08-072001-03-09Canada
Daytime Sinus Relief Extra Strength TabletsTabletOralPharmetics (2011) Inc.2004-08-17Not applicableCanada
DELTUSS DMX Cough Suppressant Nasal Decongestant Antihistamine GRAPE FlavorLiquidOralDeliz Pharmaceutical Corp2015-03-20Not applicableUs
DELTUSS DP Nasal Decongestant Antihistamine CHERRY FlavorLiquidOralDeliz Pharmaceutical Corp2015-03-20Not applicableUs
Demdec SyrSyrupOralRougier Pharma Division Of Ratiopharm Inc1993-12-311999-09-27Canada
DESGEN DM TabsTabletOralKramer Novis.2015-08-26Not applicableUs
Despec-DM TabsTabletOralInternational Ethical Labs.2014-08-25Not applicableUs
Despec-TabTabletOralInternational Ethical Labs.2014-08-25Not applicableUs
Dexbrompherniramine Maleate and Pseudoephedrine Sulfate 6mg/120mgTablet, extended releaseOralKvk Tech,Inc2013-02-27Not applicableUs
Dicel CDLiquidOralCentrix Pharmaceutical2010-05-062016-10-22Us
Dimetane DXSyrupOralCreekwood Pharmaceuticals, Inc.2011-02-262016-11-29Us
Dimetapp Children's Cough and Cold LiquidLiquidOralWhitehall Robins Inc.2001-01-232001-07-26Canada
Dimetapp Cold and Sinus CapletsTabletOralWhitehall Robins Inc.2002-09-102004-08-05Canada
Dimetapp Cough & Congestion LiquidLiquidOralWyeth Ltd.2001-01-232012-08-02Canada
Dimetapp Daytime Cold CapletsTabletOralWyeth Ltd.2001-01-232006-07-24Canada
Dimetapp Daytime Cold Extra Strength CapletsTabletOralPfizer Laboratories Div Pfizer Inc.2001-01-23Not applicableCanada
DM Plus Decongestant Cough SyrupSyrupOralTechnilab Pharma Inc.1995-12-312005-08-05Canada
DM Plus Decongestant Plus Expector.ex.st.syrSyrupOralTechnilab Pharma Inc.1995-12-312005-08-05Canada
DM Plus Decongestant Plus Expectorant Cough SyrupSyrupOralTechnilab Pharma Inc.1994-12-312005-08-05Canada
DM-D-expectorant Cough and Cold SyrupLiquidOralD.C. Labs Limited1997-10-062003-07-11Canada
DM-decongestant Children's SyrupSyrupOralTrillium Health Care Products Inc2000-03-06Not applicableCanada
DM-decongestant SyrupSyrupOralTrillium Health Care Products Inc2000-02-29Not applicableCanada
DM-decongestant-expectorant (extra Strength) SyrupSyrupOralTrillium Health Care Products Inc2000-02-29Not applicableCanada
DM-decongestant-expectorant SyrupSyrupOralTrillium Health Care Products Inc2000-03-06Not applicableCanada
Dristan Nd CapletsTabletOralPfizer Laboratories Div Pfizer Inc.1993-12-31Not applicableCanada
Dristan Non-drowsy Extra Strength CapletTabletOralPfizer Laboratories Div Pfizer Inc.1993-12-31Not applicableCanada
Dristan Sinus CapletsTabletOralWhitehall Robins Inc.1996-10-222004-08-05Canada
Drixoral Cold & SinusTablet, extended releaseOralBayer Inc Consumer Care1974-12-31Not applicableCanada
Drixoral Day/night - Srt/tabsTablet; Tablet, extended releaseOralSchering Plough1996-09-192012-07-24Canada
Drixoral SyrupSyrupOralSchering Plough1996-12-312012-07-24Canada
Drixtab TabTabletOralSchering Plough1980-12-312012-07-24Canada
Dry Cough & Cold SyrupSyrupOralPharmetics (2011) Inc.Not applicableNot applicableCanada
DryMaxSyrupOralJay Mac Pharmaceuticals2010-01-182016-10-13Us
DryMax AFSyrupOralJay Mac Pharmaceuticals2011-09-232016-10-13Us
DurafluTablet, film coatedOralPoly Pharmaceuticals2011-02-102016-12-30Us
Ed-A-hist PseTablet, coatedOralEdwards Pharmaceuticals, Inc2011-10-08Not applicableUs
Entex LATablet, extended releaseOralPurdue Pharma2004-02-02Not applicableCanada
Entex TTabletOralWraser Pharmaceuticals2010-09-30Not applicableUs
Entre-CoughLiquidOralAcella Pharmaceuticals, LLC2013-02-04Not applicableUs
Entre-SSyrupOralBrookstone Pharmaceuticals, Inc.2009-12-152016-12-09Us
Ephed Plus SinusTabletOralDickey Consumer Products DBA DMD2011-10-18Not applicableUs
Equaline All Day Allergy DTablet, extended releaseOralSupervalu2008-07-30Not applicableUs
Equaline Allergy and Congestion ReliefTablet, extended releaseOralSupervalu2013-02-13Not applicableUs
Equaline Ibuprofen Cold and SinusTablet, sugar coatedOralSupervalu2004-09-21Not applicableUs
Equate Allergy Relief DTablet, extended releaseOralWalmart Stores2008-04-09Not applicableUs
Equate Daytime Liquid CapsulesCapsuleOralIvax Pharmaceuticals IncorporatedNot applicableNot applicableCanada
Equate Ibuprofen Cold and SinusTablet, sugar coatedOralWalmart Stores2001-11-07Not applicableUs
Equate Nighttime Liquid CapsulesCapsuleOralIvax Pharmaceuticals IncorporatedNot applicableNot applicableCanada
ExeFen DMXTabletOralLarken Laboratories, Inc.2011-03-282015-12-29Us
Expectorant DM Cough Extra Strength With DecongestantSyrupOralTanta Pharmaceuticals IncNot applicableNot applicableCanada
Extra Strength Allergy and Sinus ReliefTabletOralPendopharm Division Of De Pharmascience Inc2002-02-152014-02-10Canada
Extra Strength Allergy Plus Sinus ReliefTabletOralKsl Pharmaceuticals1995-12-312002-07-31Canada
Extra Strength Allergy Sinus MedicationTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1995-12-312005-07-20Canada
Extra Strength Allergy TotalTabletOralVita Health Products Inc2008-03-11Not applicableCanada
Extra Strength Cold Medication Daytime ReliefTabletOralVita Health Products Inc1995-12-31Not applicableCanada
Extra Strength Cold Medication Daytime RlfTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1995-12-312005-07-20Canada
Extra Strength Cold Medication Nighttime ReliefTabletOralVita Health Products Inc1995-12-31Not applicableCanada
Extra Strength Cold Medication Nighttime RlfTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1995-12-312006-07-31Canada
Extra Strength Cough Plus Cold Relief SyrupSyrupOralPharmetics (2011) Inc.2006-11-13Not applicableCanada
Extra Strength Day and Night Cold MedicationKit; TabletOralPendopharm Division Of De Pharmascience IncNot applicableNot applicableCanada
Extra Strength Daytime Cold ReliefTabletOralPendopharm Division Of De Pharmascience Inc2002-02-082014-09-19Canada
Extra Strength Daytime Cold Relief-capletTabletOralKsl Pharmaceuticals1995-12-312002-07-31Canada
Extra Strength Flu Relief DaytimeTabletOralVita Health Products Inc2004-03-01Not applicableCanada
Extra Strength Flu Relief NightimeTabletOralVita Health Products Inc2004-01-07Not applicableCanada
Extra Strength Head Cold and SinusTabletOralVita Health Products Inc2004-04-01Not applicableCanada
Extra Strength Neocitran Flu NightKit; PowderOralNovartis1997-11-112016-08-02Canada
Extra Strength Neocitran Total NightPowder, for solutionOralNovartis2005-08-082016-08-02Canada
Extra Strength Nighttime Cold ReliefTabletOralPendopharm Division Of De Pharmascience Inc2002-02-082016-10-25Canada
Extra Strength Nighttime Cold Relief-capletTabletOralKsl Pharmaceuticals1995-12-312002-07-31Canada
Extra Strength Sinus Medication-capletTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1995-12-312002-07-31Canada
Extra Strength Sinus ReliefTabletOralPendopharm Division Of De Pharmascience Inc2002-02-082016-10-25Canada
Extra Strength Sinus Relief DaytimeTabletOralVita Health Products Inc1996-10-11Not applicableCanada
Extra Strength Sinus Relief NighttimeTabletOralVita Health Products Inc2003-04-252013-06-25Canada
Extra Strength Sinus Relief-capletTabletOralKsl Pharmaceuticals1995-12-312002-07-31Canada
Extra Strength Tylenol Allergy Sinus CapletsTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1993-12-312016-01-22Canada
Extra Strength Tylenol Allergy Sinus Nighttime CapletTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2000-05-122016-01-22Canada
Extra Strength Tylenol Cold & Sinus DaytimeTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2010-08-11Not applicableCanada
Extra Strength Tylenol Cold & Sinus NighttimeTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2010-08-11Not applicableCanada
Extra Strength Tylenol Cold and Flu PowderPowder, for solutionOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1991-12-312004-07-22Canada
Extra Strength Tylenol Cold DaytimeTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1987-12-312016-01-22Canada
Extra Strength Tylenol Cold Nighttime CapletTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1987-12-312016-08-05Canada
Extra Strength Tylenol Complete Cold, Cough & FluTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2010-08-11Not applicableCanada
Extra Strength Tylenol Complete Cold, Cough & Flu DaytimeTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2011-08-08Not applicableCanada
Extra Strength Tylenol Complete Cold, Cough & Flu NighttimeTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2011-08-08Not applicableCanada
Extra Strength Tylenol Complete Cold, Cough & Flu Plus Mucus ReliefSyrupOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2011-08-08Not applicableCanada
Extra Strength Tylenol Complete Cold, Cough & Flu Plus Mucus Relief NighttimeSyrupOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2011-08-08Not applicableCanada
Extra Strength Tylenol Flu DaytimeTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2000-05-122016-01-22Canada
Extra Strength Tylenol Flu Nighttime GelcapTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1995-12-312016-01-22Canada
Extra Strength Tylenol Sinus Pain and Congestion DaytimeTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1986-12-312016-01-22Canada
Extra Strength Tylenol Sinus Pain and Congestion NighttimeTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2005-08-232016-01-22Canada
Fexofenadine HCl and Pseudoephedrine HCITablet, extended releaseOralWalgreens2015-07-17Not applicableUs
Fexofenadine HCl and Pseudoephedrine HClTablet, extended releaseOralDr Reddy's Laboratories2011-01-28Not applicableUs55111 0572 01 nlmimage10 ea07f53f
FEXOFENADINE HYDROCHLORIDE and PSEUDOEPHEDRINE HYDROCHLORIDETablet, film coated, extended releaseOralRebel Distributors2009-11-02Not applicableUs
Flu ReliefKit; TabletOralVita Health Products Inc2012-08-28Not applicableCanada
Flu, Cough & Cold CompleteTabletOralVita Health Products Inc2012-05-05Not applicableCanada
Flu, Cough & Cold Complete Day and NightKit; TabletOralVita Health Products Inc2012-07-03Not applicableCanada
Formule 115 DMSyrupOralFrega Inc.1982-12-312007-07-09Canada
G-Con-XLiquidOralMclaren Medical Inc2014-02-11Not applicableUs
G-Tuss-NLLiquidOralMclaren Medical Inc2014-02-11Not applicableUs
G-Tuss-NL PedLiquidOralMclaren Medical Inc2014-02-11Not applicableUs
G-Xpect PSELiquidOralMclaren Medical Inc2014-02-11Not applicableUs
GlentussSyrupOralGlendale Inc2015-12-05Not applicableUs
Good Neighbor Pharmacy All Day Allergy DTablet, extended releaseOralAmerisource Bergen2008-05-06Not applicableUs
Good Neighbor Pharmacy Childrens Ibuprofen ColdSuspensionOralAmerisource Bergen1989-04-15Not applicableUs
Good Neighbor Pharmacy Ibuprofen Cold and SinusTabletOralAmerisource Bergen2001-10-15Not applicableUs
Good Neighbor Pharmacy Loratadine DTablet, extended releaseOralAmerisource Bergen2012-03-23Not applicableUs
Good Neighbor Pharmacy loratadine d 24 hourTablet, extended releaseOralAmerisource Bergen2003-06-23Not applicableUs
Good Neighbor Pharmacy Mucus DTabletOralAmerisource Bergen2015-12-21Not applicableUs
Good Neighbor Pharmacy Night Time DLiquidOralAmerisource Bergen1994-08-28Not applicableUs
Good Neighbor Pharmacy Sinus and Cold DTablet, film coatedOralAmerisource Bergen2013-08-22Not applicableUs
Good Sense All Day Allergy DTablet, extended releaseOralL. Perrigo Company2008-05-02Not applicableUs
Good Sense Allergy and Congestion ReliefTablet, extended releaseOralL. Perrigo Company2012-04-04Not applicableUs
Good Sense Allergy and Congestion Relief Non Drowsy 24 HourTablet, extended releaseOralL. Perrigo Company2003-06-24Not applicableUs
Good Sense Ibuprofen Cold and SinusTablet, sugar coatedOralL. Perrigo Company2001-10-09Not applicableUs
Good Sense Mucus DTablet, extended releaseOralL. Perrigo Company2016-03-15Not applicableUs
GripmaxTabletOralUnipharm, Inc.2014-06-01Not applicableUs
Guaifenesin and pseudoephedrine hydrochloride Extended ReleaseTablet, extended releaseOralPerrigo New York Inc.2016-01-29Not applicableUs
Guaifenesin DACLiquidOralRising Pharmaceuticals2009-09-28Not applicableUs
Harris Teeter All Day Allergy DTablet, extended releaseOralHarris Teeter2015-07-24Not applicableUs
Harris Teeter Allergy and Congestion ReliefTablet, extended releaseOralHarris Teeter2016-09-16Not applicableUs
Harris Teeter Mucus Relief DTablet, extended releaseOralHarris Teeter2016-09-16Not applicableUs
Head Cold and Sinus Relief CapletsTabletOralPharmetics (2011) Inc.Not applicableNot applicableCanada
Health Mart Allergy and CongestionTablet, extended releaseOralMc Kesson2012-03-06Not applicableUs
Health Mart Allergy Complete DTablet, extended releaseOralMc Kesson2012-01-13Not applicableUs
Health Mart mucus relief dTabletOralMc Kesson2015-12-21Not applicableUs
Health Mart Sinus and Cold DTablet, film coatedOralMc Kesson2013-08-15Not applicableUs
Healthy Accents Allergy and Congestion Relief 24 Hour Non DrowsyTablet, extended releaseOralDza Brands,2011-06-23Not applicableUs
Healthy Accents Cetirizine-DTablet, extended releaseOralDza Brands,2011-07-13Not applicableUs
healthy accents mucus relief DTablet, extended releaseOralDza Brands,2016-08-25Not applicableUs
Histenol Cold TabletsTabletOralZee Medical Inc1991-12-312007-03-06Canada
Hot Lemon Night Time Total Extra StrengthPowderOralPharmetics (2011) Inc.Not applicableNot applicableCanada
Hot Lemon Relief for Sore Throat and Cough Extra StrengthPowderOralJamp Pharma CorporationNot applicableNot applicableCanada
Hot Lemon Relief for Symptoms Of Cough, Cold and FluPowderOralPatheon LaboratoriesNot applicableNot applicableCanada
Hot Lemon Relief for Symptoms Of Cough, Cold and Flu Extra StrengthPowderOralPharmetics (2011) Inc.2004-02-13Not applicableCanada
HycofenixLiquidOralMission Pharmacal2015-08-18Not applicableUs
Hydrocodone bitartrate and pseudoephedrine hydrochloride solutionSolutionOralTris Pharma, Inc.2014-12-312016-11-18Us
Hydrocodone Bitartrate Chlorpheniramine Maleate and Pseudoephedrine HydrochlorideSolutionOralBio Pharm, Inc.2017-05-16Not applicableUs
Hydrocodone Bitartrate, Chlorpheniramine Maleate and Pseudoephedrine HydrochlorideSolutionOralPaddock Laboratories, Inc.2014-08-26Not applicableUs
Hydrocodone Bitartrate, Chlorpheniramine Maleate, and Pseudoephedrine HClSolutionOralCypress Pharmaceuticals, Inc.2014-01-09Not applicableUs
Hydrocodone Bitartrate, Chlorpheniramine Maleate, and Pseudoephedrine Hydrochloride Oral SolutionSolutionOralTris Pharma, Inc.2015-01-042016-11-30Us
Ibu Profen Cold and SinusTablet, sugar coatedOralRite Aid2001-10-08Not applicableUs
Ibuprofen + Pseudoephedrine CapletsTabletOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ibuprofen and PseudoephedrineTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2005-11-162016-01-22Canada
Ibuprofen and Pseudoephedrine HydrochlorideTablet, coatedOralWalgreen2001-10-08Not applicableUs
Ibuprofen Cold and SinusTablet, sugar coatedOralKroger2001-10-12Not applicableUs
Ibuprofen Cold and Sinus A P JTablet, coatedOralA P J Laboratories Limited2013-06-01Not applicableUs
Ibuprofen Cold ChildrensSuspensionOralMeijer Distribution2004-02-042017-01-27Us
Ibuprofen Cold Relief ChildrensSuspensionOralCvs Health2004-02-122016-10-13Us
Infants Tylenol Cold Suspension DropsSuspensionOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1997-08-112007-11-05Canada
J-cof DhcLiquidOralJay Mac Pharmaceuticals2008-06-302016-10-13Us
J-tan D PdLiquidOralJay Mac Pharmaceuticals2007-06-052016-10-13Us
Jack & Jill Cough and ColdLiquidOralThe Buckley's Company2001-09-042013-09-04Canada
Jack & Jill Cough, Cold & Flu Junior Strength TabletsTabletOralThe Buckley's Company2001-10-122011-07-26Canada
Junior Strength Cold DM - TabletTabletOralVita Health Products Inc1996-10-112009-08-06Canada
Junior Strength Tylenol Cold and CoughTablet, chewableOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1991-12-312016-01-22Canada
Junior Strength Tylenol Complete Cold, Cough & FeverTablet, chewableOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2011-10-192016-01-22Canada
Junior Strength Tylenol Decongestant - TabTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Kidkare cough/coldLiquidOralRugby2011-01-13Not applicableUs
Kirkland Signature Aller Tec DTablet, extended releaseOralCostco Wholesale2008-04-21Not applicableUs
Kirkland Signature AllerClear D 12 hrTablet, extended releaseOralCostco Wholesale2013-01-10Not applicableUs
Kirkland Signature Allerclear D 24hrTablet, extended releaseOralCostco Wholesale2007-05-21Not applicableUs
Koffex DM + Decongestant SyrupSyrupOralTechnilab Pharma Inc.1994-12-312003-09-24Canada
Koffex DM + Decongestant + ExpectorantSyrupOralTechnilab Pharma Inc.2001-01-102003-09-24Canada
Koffex DM + Decongestant + Expectorant Extra StrengthSyrupOralTechnilab Pharma Inc.1999-04-282003-09-24Canada
Koffex DM-D-E - LiqLiquidOralRougier Pharma Division Of Ratiopharm Inc1997-02-202003-09-22Canada
Leader Allergy D 12Tablet, extended releaseOralCardinal Health2008-05-14Not applicableUs
Leader Allergy Relief D-24Tablet, film coated, extended releaseOralCardinal Health2004-11-17Not applicableUs
Leader Ibuprofen Cold and SinusTablet, sugar coatedOralCardinal Health2001-10-10Not applicableUs
Leader Ibuprofen Cold ChildrensSuspensionOralCardinal Health2004-03-252016-11-15Us
Leader Sinus and Cold-DTablet, film coatedOralCardinal Health2013-11-05Not applicableUs
LiberatorTablet, extended releaseOralSchering Plough2002-04-082012-07-24Canada
Lodrane DCapsuleOralECR Pharmaceuticals Co., Inc.2011-10-21Not applicableUs
LoHist DLiquidOralLarken Laboratories, Inc.2003-09-15Not applicableUs
Loratadine and PseudoephedrineTablet, film coated, extended releaseOralWalgreen2013-11-07Not applicableUs
Loratadine and Pseudoephedrine SulfateTablet, film coated, extended releaseOralMajor2004-11-17Not applicableUs
Loratadine DTablet, extended releaseOralbryant ranch prepack2012-01-19Not applicableUs
Loratadine D 24 HourTablet, extended releaseOralPerrigo New York Inc.2014-04-25Not applicableUs
Lortuss DMLiquidOralSallus Laboratories, Llc2014-06-14Not applicableUs
Lortuss EXLiquidOralSallus Laboratories, Llc2014-06-01Not applicableUs
Lortuss LqLiquidOralPoly Pharmaceuticals2011-02-22Not applicableUs
M-end DMLiquidOralR. A. Mc Neil Company2008-11-132017-02-07Us
M-end DmxLiquidOralR. A. Mc Neil Company2011-10-13Not applicableUs
M-end Max DLiquidOralR. A. Mc Neil Company2011-10-132017-02-28Us
M-end WcLiquidOralR. A. Mc Neil Company2008-09-302017-02-04Us
Mar-cof BPSyrupOralMarnel Pharmaceuticals, Llc2009-10-01Not applicableUs
Maux De Gorge Et De LA Toux Extra-fortPowderOralPharmalab Inc.Not applicableNot applicableCanada
Maximum Strength Allergy SinusTabletOralWalgreen1999-10-01Not applicableUs
Medicament Pour Le Rhume, JourTabletOralLaboratoire Riva IncNot applicableNot applicableCanada
Medicament Pour Le Rhume, NuitTabletOralLaboratoire Riva IncNot applicableNot applicableCanada
Medicament Pour Les Sinus Reg CapletTabletOralProdemdis Enr.1991-12-312010-07-15Canada
Medicament Pour Les Sinus, Extra-fortTabletOralLaboratoire Riva Inc2000-04-19Not applicableCanada
Medicament Pour Les Sinus, RegulierTabletOralLaboratoire Riva Inc2000-04-19Not applicableCanada
Medicament Sinus Personnel EX-fort CapletTabletOralProdemdis Enr.1991-12-312008-08-08Canada
Medicament Sinus Personnel Reg CapletTabletOralProdemdis Enr.1991-12-312008-08-08Canada
Medicine Shoppe Allergy Relief D24Tablet, film coated, extended releaseOralMedicine Shoppe International2004-11-17Not applicableUs
Motrin Cold & Sinus CapletsTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Motrin Cold & Sinus PainTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2009-08-102016-08-05Canada
Mucinex DTablet, extended releaseOralPhysicians Total Care, Inc.2008-01-07Not applicableUs
Mucinex D Maximum StrengthTablet, extended releaseOralReckitt Benckiser2012-06-26Not applicableUs
Mucus DTablet, extended releaseOralMeijer Distribution2015-12-16Not applicableUs
Mucus D ERTablet, extended releaseOralPublix Supermarkets, Inc.2016-06-23Not applicableUs
Mucus Relief DTabletOralRite Aid2015-12-18Not applicableUs
Neo ACSyrupOralLaser Pharmaceuticals Llc2009-09-22Not applicableUs
Neo Citran Daycaps Extra Strength - CapletTabletOralNovartis1994-12-311999-07-21Canada
Neo DMSyrupOralLaser Pharmaceuticals Llc2008-01-02Not applicableUs
Neocitran Cold & Flu SyrupSyrupOralNovartis2004-07-302007-07-18Canada
Neocitran Cough & Cold SyrupSyrupOralNovartis2004-07-302007-07-18Canada
Neocitran Ultra Strength Total FluPowder, for solutionOralGlaxosmithkline Inc2014-10-06Not applicableCanada
Neocitran Ultra Strength Total Flu NightPowderOralGlaxosmithkline Inc1998-08-28Not applicableCanada
Nicold Medicine for AdultsSyrupOralTanta Pharmaceuticals IncNot applicableNot applicableCanada
Night Relief Cold and Flu Liquid CapsulesCapsuleOralBanner Pharmacaps2005-01-052009-08-07Canada
Night Time Cold and FluLiquidOralSafeway1994-07-19Not applicableUs
Night Time Multi Symptom ReliefCapsuleOralStrides Pharma IncNot applicableNot applicableCanada
Night Time ReliefCapsuleOralStrides Pharma IncNot applicableNot applicableCanada
Night Time Total Extra StrengthPowderOralPharmetics (2011) Inc.2010-12-08Not applicableCanada
Nightcap Complete Liquid GelsCapsuleOralAccucaps Industries LimitedNot applicableNot applicableCanada
Nighttime 325 Liqua CapsCapsuleOralJamp Pharma CorporationNot applicableNot applicableCanada
Nighttime Cold & Flu Liquid CapsulesCapsuleOralVita Health Products Inc1996-12-312008-08-05Canada
Nighttime Cold & Flu Relief SyrupSyrupOralPharmetics (2011) Inc.Not applicableNot applicableCanada
Nighttime Cold and Flu Extra Strength MedicineLiquidOralJamp Pharma CorporationNot applicableNot applicableCanada
Nighttime Cold and Flu Liquid CapsulesCapsuleOralVita Health Products Inc1997-02-192003-11-07Canada
Nighttime Cold and Flu ReliefCapsuleOralPharmetics (2011) Inc.2005-09-13Not applicableCanada
Nighttime Cold and Flu-IN-one Extra StrengthTabletOralVita Health Products Inc2008-04-21Not applicableCanada
Nighttime Cold Relief Extra Strength TabletsTabletOralPharmetics (2011) Inc.2004-08-25Not applicableCanada
Nighttime Cough. Cold. Flu Gel CapsulesCapsuleOralApotex Inc., Private Label DivisionNot applicableNot applicableCanada
Nighttime D Cold and FluLiquidOralHyvee1994-02-14Not applicableUs
Nighttime D Cold and Flu ReliefLiquidOralWalgreen2002-06-19Not applicableUs
Nighttime Flu, Cough & Cold Complete Relief Extra StrengthTabletOralVita Health Products Inc2014-07-16Not applicableCanada
Nighttime Liqua CapsCapsuleOralJamp Pharma Corporation2006-02-13Not applicableCanada
Nighttime Super Strength Contac CompleteTabletOralGlaxosmithkline Inc1997-07-082009-07-28Canada
Nighttime Total Cold and FluTabletOralVita Health Products Inc2009-03-01Not applicableCanada
Nighttime Total Super StrengthPowder, for solutionOralThe Winning Combination Inc.Not applicableNot applicableCanada
Ninjacof-DLiquidOralCenturion Labs2017-08-16Not applicableUs
Nite Time (children's)LiquidOralPerrigo International1999-06-182007-04-16Canada
NiteTimeLiquidOralKroger1994-05-09Not applicableUs
Nitetime Cold MedicineLiquidOralIvc Industries, Hall Division1997-11-241998-07-17Canada
Nitetime Cold Medicine LiqLiquidOralJamp Pharma Corporation1992-12-31Not applicableCanada
Nitetime Cold Medicine Original and CherryLiquidOralWestcan Pharmaceuticals Ltd.Not applicableNot applicableCanada
Nitetime DLiquidOralMeijer Distribution1994-03-29Not applicableUs
Nitetime D multi symptom cold flu reliefLiquidOralMeijer Distribution1994-02-01Not applicableUs
Non Drowsy Extra Strength Contac Cold Sore ThroatTabletOralGlaxosmithkline Inc1992-12-312008-08-01Canada
Non Drowsy Regular Strength Contac Cold Chest CongestionCapsuleOralGlaxosmithkline Inc1998-10-272008-08-01Canada
Non Drowsy Regular Strength Contac CompleteTabletOralGlaxosmithkline Inc2004-06-202008-08-01Canada
Non Drowsy Super Strength Contac Cold Nasal CongestionTabletOralGlaxosmithkline Inc2004-06-302008-08-01Canada
Non Drowsy Super Strength Contac CompleteTabletOralGlaxosmithkline Inc1993-12-312009-07-28Canada
Notuss-NXDLiquidOralSj Pharmaceuticals, Llc2010-11-03Not applicableUs
Novahistex DM Expectorant With DecongestantLiquidOralW.K. Buckley Ltd.1994-12-312002-04-02Canada
Novahistex DM With DecongestantLiquidOralW.K. Buckley Ltd.1995-12-312002-04-02Canada
Novahistex Expectorant With DecongestantLiquidOralHoechst Marion Roussel1994-12-311996-12-09Canada
Novahistine DM Expectorant With DecongestantLiquidOralW.K. Buckley Ltd.1995-12-312002-04-02Canada
Novahistine DM With Decongestant - LiqLiquidOralW.K. Buckley Ltd.1994-12-312002-04-02Canada
Nyquil LiquicapsCapsuleOralProcter And Gamble1993-12-312005-07-28Canada
Once-A-day Benylin Cold CapCapsule, extended releaseOralKv Pharmaceutical Company1990-12-312002-04-29Canada
P.M. Cold Relief FormulaCapsuleOralIvax Pharmaceuticals IncorporatedNot applicableNot applicableCanada
Pain & Fever + ColdSuspensionOralAccudial Pharmaceutical, Inc.2012-10-01Not applicableCanada
Pain & Fever + Cold & CoughSuspensionOralAccudial Pharmaceutical, Inc.2012-10-01Not applicableCanada
Pain & Fever + DecongestantSuspensionOralAccudial Pharmaceutical, Inc.Not applicableNot applicableCanada
Panatuss PEDLiquidOralSeyer Pharmatec, Inc.2012-12-15Not applicableUs
PECGEN PSE Cough Suppressant Expectorant Nasal Decongestant GRAPE FlavorLiquidOralKramer Novis.2014-08-08Not applicableUs
Pedia ReliefLiquidOralMajor1997-01-05Not applicableUs
Pediatric Cough and Cold MedicineLiquidOralSilarx Pharmaceuticals, Inc.1997-01-05Not applicableUs
Pediatric Cough SyrupSyrupOralTechnilab Pharma Inc.1995-12-312000-09-07Canada
Personnelle Contre Le Rhume LiqLiquidOralTherapex Division De E Z Em Canada Inc1992-12-312007-09-04Canada
Personnelle DM SyrSyrupOralTherapex Division De E Z Em Canada Inc1994-12-312000-08-01Canada
Phenylhistine DHLiquidOralQualitest1996-10-012018-04-30Us
Poly Hist NCLiquidOralPoly Pharmaceuticals2010-01-01Not applicableUs
Poly-tussin DLiquidOralPoly Pharmaceuticals2012-09-18Not applicableUs
Poly-Vent DMTabletOralPoly Pharmaceuticals2013-06-17Not applicableUs
Poly-Vent IRTabletOralPoly Pharmaceuticals2013-06-11Not applicableUs
Preferred Plus Allergy and Congestion ReliefTablet, extended releaseOralKinray2015-02-12Not applicableUs
Preferred Plus Sinus and Cold DTablet, film coatedOralKinray2015-05-18Not applicableUs
Prime's Sore Throat, Cough and Colds CapsulesCapsuleOralPrime Packaging, Inc.Not applicableNot applicableCanada
Promatussin DM Adult Formula SyrSyrupOralWyeth Ayerst Canada Inc.1993-12-311996-09-10Canada
Promatussin DM Children FormulaLiquidOralWyeth Ltd.1981-12-311996-09-10Canada
Pseudoephedrine PlusTabletOralContract Pharmacal Corporation2001-02-20Not applicableUs
Q Tapp Cold and AllergyLiquidOralQualitest2002-04-032017-09-30Us
Q Tapp Cold and CoughLiquidOralQualitest2002-04-022018-01-31Us
Q-TappElixirOralQualitest2001-04-052016-11-15Us
Q-Tapp DM ElixirElixirOralQualitest2001-04-052016-12-13Us
Ratio-cotridinSyrupOralTeva1996-07-30Not applicableCanada
Ratio-cotridin ExpectorantSyrupOralTeva1994-12-31Not applicableCanada
Reactine CompleteTablet, extended releaseOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2003-03-07Not applicableCanada
Reg.str.cold Medic.(night Time Relief)capletTabletOralWestcan Pharmaceuticals Ltd.1995-12-312002-07-31Canada
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Sinutab N.D.reg Strength TabTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1991-12-312016-08-05Canada
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Smart Sense Allergy and Congestion ReliefTablet, extended releaseOralKmart Corporation2011-07-21Not applicableUs
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Sudafed Cold and Cough Extra Strength CapletsTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2000-03-012016-06-27Canada
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Sudafed Sinus & AllergyTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Sudafed Sinus AdvanceTabletOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2000-08-01Not applicableCanada
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Sunmark All Day Allergy DTablet, extended releaseOralMc Kesson2008-04-18Not applicableUs
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Total Cold and Flu Extra StrengthSyrupOralTrillium Health Care Products Inc2007-07-11Not applicableCanada
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Tylenol Cold & Flu NighttimeLiquidOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2005-08-222008-08-07Canada
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Zodryl DEC 50SuspensionOralCoda Dose, Inc.2009-08-24Not applicableUs
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Categories
UNII
7CUC9DDI9F
CAS number
90-82-4
Weight
Average: 165.2322
Monoisotopic: 165.115364107
Chemical Formula
C10H15NO
InChI Key
KWGRBVOPPLSCSI-WCBMZHEXSA-N
InChI
InChI=1S/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/t8-,10+/m0/s1
IUPAC Name
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol
SMILES
CN[C@@H](C)[C@@H](O)C1=CC=CC=C1

Pharmacology

Indication

For the treatment of nasal congestion, sinus congestion, Eustachian tube congestion, and vasomotor rhinitis, and as an adjunct to other agents in the optimum treatment of allergic rhinitis, croup, sinusitis, otitis media, and tracheobronchitis. Also used as first-line therapy of priapism.

Structured Indications
Pharmacodynamics

Pseudoephedrine is a sympathomimetic agent, structurally similar to ephedrine, used to relieve nasal and sinus congestion and reduce air-travel-related otalgia in adults. The salts pseudoephedrine hydrochloride and pseudoephedrine sulfate are found in many over-the-counter preparations either as single-ingredient preparations, or more commonly in combination with antihistamines and/or paracetamol/ibuprofen. Unlike antihistamines, which modify the systemic histamine-mediated allergic response, pseudoephedrine only serves to relieve nasal congestion commonly associated with colds or allergies. The advantage of oral pseudoephedrine over topical nasal preparations, such as oxymetazoline, is that it does not cause rebound congestion (rhinitis medicamentosa).

Mechanism of action

Pseudoephedrine acts directly on both alpha- and, to a lesser degree, beta-adrenergic receptors. Through direct action on alpha-adrenergic receptors in the mucosa of the respiratory tract, pseudoephedrine produces vasoconstriction. Pseudoephedrine relaxes bronchial smooth muscle by stimulating beta2-adrenergic receptors. Like ephedrine, pseudoephedrine releasing norepinephrine from its storage sites, an indirect effect. This is its main and direct mechanism of action. The displaced noradrenaline is released into the neuronal synapse where it is free to activate the postsynaptic adrenergic receptors.

TargetActionsOrganism
ASodium-dependent noradrenaline transporter
inhibitor
Human
ASodium-dependent dopamine transporter
inhibitor
Human
AAlpha-1A adrenergic receptor
agonist
Human
AAlpha-2A adrenergic receptor
agonist
Human
ASodium-dependent serotonin transporter
inhibitor
Human
UBeta-2 adrenergic receptor
partial agonist
Human
UBeta-1 adrenergic receptor
agonist
partial agonist
Human
UNuclear factor of activated T-cells, cytoplasmic 1Not AvailableHuman
UTumor necrosis factorNot AvailableHuman
UNuclear factor kappa-light-chain-enhancer of activated B cellsNot AvailableHuman
Uactivator protein 1Not AvailableHuman
UInterleukin-2Not AvailableHuman
Absorption

Pseudoephedrine is readily and almost completely absorbed from the GI tract and there is no evidence of first-pass metabolism.

Volume of distribution
Not Available
Protein binding

Pseudoephedrine does not bind to human plasma proteins over the concentration range of 50 to 2000 ng/mL

Metabolism

Hepatic.

Route of elimination
Not Available
Half life

9-16 hours

Clearance
Not Available
Toxicity

Common adverse reactions include nervousness, restlessness, and insomnia. Rare adverse reactions include difficult/painful urination, dizziness/lightheadedness, heart palpitations, headache, increased sweating, nausea/vomiting, trembling, troubled breathing, unusual paleness, and weakness.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE may increase the hypertensive activities of Pseudoephedrine.Experimental
AbirateroneThe serum concentration of Pseudoephedrine can be increased when it is combined with Abiraterone.Approved
AcebutololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Acebutolol.Approved
AcepromazineAcepromazine may decrease the stimulatory activities of Pseudoephedrine.Approved, Vet Approved
AceprometazineAceprometazine may decrease the stimulatory activities of Pseudoephedrine.Approved
AcetazolamideAcetazolamide may decrease the excretion rate of Pseudoephedrine which could result in a higher serum level.Approved, Vet Approved
AcetophenazineAcetophenazine may decrease the stimulatory activities of Pseudoephedrine.Approved
AcrivastinePseudoephedrine may decrease the sedative activities of Acrivastine.Approved
AlcaftadinePseudoephedrine may decrease the sedative activities of Alcaftadine.Approved
AlfentanilPseudoephedrine may increase the analgesic activities of Alfentanil.Approved, Illicit
AlfuzosinAlfuzosin may decrease the vasoconstricting activities of Pseudoephedrine.Approved, Investigational
AlimemazinePseudoephedrine may decrease the sedative activities of Alimemazine.Approved, Vet Approved
AlphacetylmethadolPseudoephedrine may increase the analgesic activities of Alphacetylmethadol.Experimental, Illicit
AlprenololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Alprenolol.Approved, Withdrawn
Aluminum hydroxideAluminum hydroxide may decrease the excretion rate of Pseudoephedrine which could result in a higher serum level.Approved
AmineptineAmineptine may decrease the antihypertensive activities of Pseudoephedrine.Illicit, Withdrawn
AmiodaroneThe metabolism of Pseudoephedrine can be decreased when combined with Amiodarone.Approved, Investigational
AmisulprideAmisulpride may decrease the stimulatory activities of Pseudoephedrine.Approved, Investigational
AmitriptylineAmitriptyline may decrease the antihypertensive activities of Pseudoephedrine.Approved
Ammonium chlorideThe serum concentration of Pseudoephedrine can be decreased when it is combined with Ammonium chloride.Approved, Vet Approved
AmperozideAmperozide may decrease the stimulatory activities of Pseudoephedrine.Experimental
AmphetamineThe risk or severity of adverse effects can be increased when Amphetamine is combined with Pseudoephedrine.Approved, Illicit
AntazolinePseudoephedrine may decrease the sedative activities of Antazoline.Approved
AripiprazoleAripiprazole may decrease the stimulatory activities of Pseudoephedrine.Approved, Investigational
ArotinololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Arotinolol.Approved
ArtemetherThe metabolism of Pseudoephedrine can be decreased when combined with Artemether.Approved
AsenapineAsenapine may decrease the stimulatory activities of Pseudoephedrine.Approved
AstemizolePseudoephedrine may decrease the sedative activities of Astemizole.Approved, Withdrawn
AtenololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Atenolol.Approved
AtomoxetineAtomoxetine may increase the hypertensive activities of Pseudoephedrine.Approved
AzaperoneAzaperone may decrease the stimulatory activities of Pseudoephedrine.Vet Approved
AzatadinePseudoephedrine may decrease the sedative activities of Azatadine.Approved
AzelastinePseudoephedrine may decrease the sedative activities of Azelastine.Approved
BefunololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Befunolol.Experimental
BenmoxinBenmoxin may increase the hypertensive activities of Pseudoephedrine.Withdrawn
BenperidolBenperidol may decrease the stimulatory activities of Pseudoephedrine.Investigational
BenzphetamineThe risk or severity of adverse effects can be increased when Benzphetamine is combined with Pseudoephedrine.Approved, Illicit
Benzylpenicilloyl PolylysinePseudoephedrine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.Approved
BetaxololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Betaxolol.Approved
BevantololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Bevantolol.Approved
BezitramidePseudoephedrine may increase the analgesic activities of Bezitramide.Experimental, Illicit, Withdrawn
BifeprunoxBifeprunox may decrease the stimulatory activities of Pseudoephedrine.Investigational
Bismuth SubcitrateBismuth Subcitrate may decrease the excretion rate of Pseudoephedrine which could result in a higher serum level.Approved
BisoprololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Bisoprolol.Approved
BopindololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Bopindolol.Approved
BrexpiprazoleBrexpiprazole may decrease the stimulatory activities of Pseudoephedrine.Approved
BromocriptineBromocriptine may increase the hypertensive activities of Pseudoephedrine.Approved, Investigational
BromperidolBromperidol may decrease the stimulatory activities of Pseudoephedrine.Investigational
BrompheniraminePseudoephedrine may decrease the sedative activities of Brompheniramine.Approved
BucindololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Bucindolol.Investigational
BuclizinePseudoephedrine may decrease the sedative activities of Buclizine.Approved
BufuralolPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Bufuralol.Experimental, Investigational
BupranololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Bupranolol.Approved
BuprenorphinePseudoephedrine may increase the analgesic activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Pseudoephedrine can be decreased when combined with Bupropion.Approved
ButorphanolPseudoephedrine may increase the analgesic activities of Butorphanol.Approved, Illicit, Vet Approved
Butyric AcidPseudoephedrine may decrease the sedative activities of Butanoic Acid.Experimental
CabergolineCabergoline may increase the hypertensive activities of Pseudoephedrine.Approved
Calcium CarbonateCalcium carbonate may decrease the excretion rate of Pseudoephedrine which could result in a higher serum level.Approved
CarbinoxaminePseudoephedrine may decrease the sedative activities of Carbinoxamine.Approved
CarfentanilPseudoephedrine may increase the analgesic activities of Carfentanil.Illicit, Vet Approved
CariprazineCariprazine may decrease the stimulatory activities of Pseudoephedrine.Approved
CaroxazoneCaroxazone may increase the hypertensive activities of Pseudoephedrine.Withdrawn
CarteololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Carteolol.Approved
CarvedilolPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Carvedilol.Approved, Investigational
CelecoxibThe metabolism of Pseudoephedrine can be decreased when combined with Celecoxib.Approved, Investigational
CeliprololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Celiprolol.Approved, Investigational
CetirizinePseudoephedrine may decrease the sedative activities of Cetirizine.Approved
ChloropyraminePseudoephedrine may decrease the sedative activities of Chloropyramine.Approved
ChloroquineThe metabolism of Pseudoephedrine can be decreased when combined with Chloroquine.Approved, Vet Approved
ChlorphenaminePseudoephedrine may decrease the sedative activities of Chlorphenamine.Approved
ChlorphenoxaminePseudoephedrine may decrease the sedative activities of Chlorphenoxamine.Withdrawn
ChlorphentermineThe risk or severity of adverse effects can be increased when Chlorphentermine is combined with Pseudoephedrine.Illicit, Withdrawn
ChlorpromazineThe metabolism of Pseudoephedrine can be decreased when combined with Chlorpromazine.Approved, Vet Approved
ChlorprothixeneChlorprothixene may decrease the stimulatory activities of Pseudoephedrine.Approved, Withdrawn
CholecalciferolThe metabolism of Pseudoephedrine can be decreased when combined with Cholecalciferol.Approved, Nutraceutical
CimetidineThe metabolism of Pseudoephedrine can be decreased when combined with Cimetidine.Approved
CinacalcetThe metabolism of Pseudoephedrine can be decreased when combined with Cinacalcet.Approved
CinnarizinePseudoephedrine may decrease the sedative activities of Cinnarizine.Approved
CitalopramThe metabolism of Pseudoephedrine can be decreased when combined with Citalopram.Approved
ClemastineThe metabolism of Pseudoephedrine can be decreased when combined with Clemastine.Approved
ClenbuterolThe risk or severity of adverse effects can be increased when Clenbuterol is combined with Pseudoephedrine.Approved, Vet Approved
ClobazamThe metabolism of Pseudoephedrine can be decreased when combined with Clobazam.Approved, Illicit
ClomipramineClomipramine may decrease the antihypertensive activities of Pseudoephedrine.Approved, Vet Approved
ClotrimazoleThe metabolism of Pseudoephedrine can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe metabolism of Pseudoephedrine can be decreased when combined with Clozapine.Approved
CobicistatThe serum concentration of Pseudoephedrine can be increased when it is combined with Cobicistat.Approved
CocaineThe metabolism of Pseudoephedrine can be decreased when combined with Cocaine.Approved, Illicit
CodeinePseudoephedrine may increase the analgesic activities of Codeine.Approved, Illicit
CyamemazineCyamemazine may decrease the stimulatory activities of Pseudoephedrine.Approved
CyclizinePseudoephedrine may decrease the sedative activities of Cyclizine.Approved
CyclobenzaprineCyclobenzaprine may decrease the antihypertensive activities of Pseudoephedrine.Approved
CyproheptadinePseudoephedrine may decrease the sedative activities of Cyproheptadine.Approved
DapiprazoleDapiprazole may decrease the stimulatory activities of Pseudoephedrine.Approved
DarifenacinThe metabolism of Pseudoephedrine can be decreased when combined with Darifenacin.Approved, Investigational
DarunavirThe serum concentration of Pseudoephedrine can be increased when it is combined with Darunavir.Approved
DelavirdineThe metabolism of Pseudoephedrine can be decreased when combined with Delavirdine.Approved
DesipramineDesipramine may decrease the antihypertensive activities of Pseudoephedrine.Approved
DesloratadinePseudoephedrine may decrease the sedative activities of Desloratadine.Approved, Investigational
DesvenlafaxineDesvenlafaxine may increase the tachycardic activities of Pseudoephedrine.Approved
DexbrompheniraminePseudoephedrine may decrease the sedative activities of Dexbrompheniramine.Approved
Dexchlorpheniramine maleatePseudoephedrine may decrease the sedative activities of Dexchlorpheniramine maleate.Approved
DextromoramidePseudoephedrine may increase the analgesic activities of Dextromoramide.Experimental, Illicit
DextropropoxyphenePseudoephedrine may increase the analgesic activities of Dextropropoxyphene.Approved, Illicit, Withdrawn
DezocinePseudoephedrine may increase the analgesic activities of Dezocine.Approved
DiclofenamideDiclofenamide may decrease the excretion rate of Pseudoephedrine which could result in a higher serum level.Approved
DihydrocodeinePseudoephedrine may increase the analgesic activities of Dihydrocodeine.Approved, Illicit
DihydroergotamineDihydroergotamine may increase the hypertensive activities of Pseudoephedrine.Approved
DihydroetorphinePseudoephedrine may increase the analgesic activities of Dihydroetorphine.Experimental, Illicit
DihydromorphinePseudoephedrine may increase the analgesic activities of Dihydromorphine.Experimental, Illicit
DimenhydrinatePseudoephedrine may decrease the sedative activities of Dimenhydrinate.Approved
DimetindenePseudoephedrine may decrease the sedative activities of Dimetindene.Approved
DimetotiazinePseudoephedrine may decrease the sedative activities of Dimetotiazine.Approved
DiphenhydramineThe metabolism of Pseudoephedrine can be decreased when combined with Diphenhydramine.Approved
DiphenoxylatePseudoephedrine may increase the analgesic activities of Diphenoxylate.Approved, Illicit
DobutamineThe risk or severity of adverse effects can be increased when Dobutamine is combined with Pseudoephedrine.Approved
DopamineThe risk or severity of adverse effects can be increased when Dopamine is combined with Pseudoephedrine.Approved
DosulepinDosulepin may decrease the antihypertensive activities of Pseudoephedrine.Approved
DoxazosinDoxazosin may decrease the vasoconstricting activities of Pseudoephedrine.Approved
DoxepinDoxepin may decrease the antihypertensive activities of Pseudoephedrine.Approved
DoxofyllineThe risk or severity of adverse effects can be increased when Pseudoephedrine is combined with Doxofylline.Approved
DoxylaminePseudoephedrine may decrease the sedative activities of Doxylamine.Approved, Vet Approved
DPDPEPseudoephedrine may increase the analgesic activities of DPDPE.Investigational
DronabinolDronabinol may increase the tachycardic activities of Pseudoephedrine.Approved, Illicit
DronedaroneThe metabolism of Pseudoephedrine can be decreased when combined with Dronedarone.Approved
DroperidolDroperidol may decrease the stimulatory activities of Pseudoephedrine.Approved, Vet Approved
DuloxetineDuloxetine may increase the tachycardic activities of Pseudoephedrine.Approved
EbastinePseudoephedrine may decrease the sedative activities of Ebastine.Investigational
EcopipamEcopipam may decrease the stimulatory activities of Pseudoephedrine.Investigational
EliglustatThe metabolism of Pseudoephedrine can be decreased when combined with Eliglustat.Approved
EmedastinePseudoephedrine may decrease the sedative activities of Emedastine.Approved
EphedrineThe risk or severity of adverse effects can be increased when Ephedrine is combined with Pseudoephedrine.Approved
EpinastinePseudoephedrine may decrease the sedative activities of Epinastine.Approved, Investigational
EpinephrineThe risk or severity of adverse effects can be increased when Epinephrine is combined with Pseudoephedrine.Approved, Vet Approved
Ergoloid mesylateErgoloid mesylate may increase the hypertensive activities of Pseudoephedrine.Approved
ErgonovineErgonovine may increase the hypertensive activities of Pseudoephedrine.Approved
ErgotamineErgotamine may increase the hypertensive activities of Pseudoephedrine.Approved
EsmirtazapineEsmirtazapine may decrease the antihypertensive activities of Pseudoephedrine.Investigational
EsmololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Esmolol.Approved
EthopropazinePseudoephedrine may decrease the sedative activities of Ethopropazine.Approved
EthosuximideThe therapeutic efficacy of Ethosuximide can be decreased when used in combination with Pseudoephedrine.Approved
EthoxzolamideEthoxzolamide may decrease the excretion rate of Pseudoephedrine which could result in a higher serum level.Withdrawn
EthylmorphinePseudoephedrine may increase the analgesic activities of Ethylmorphine.Approved, Illicit
EtilefrineThe risk or severity of adverse effects can be increased when Etilefrine is combined with Pseudoephedrine.Withdrawn
EtorphinePseudoephedrine may increase the analgesic activities of Etorphine.Illicit, Vet Approved
FamotidinePseudoephedrine may decrease the sedative activities of Famotidine.Approved
FencamfamineFencamfamine may decrease the stimulatory activities of Pseudoephedrine.Approved, Illicit, Withdrawn
FenoterolThe risk or severity of adverse effects can be increased when Fenoterol is combined with Pseudoephedrine.Approved
FentanylPseudoephedrine may increase the analgesic activities of Fentanyl.Approved, Illicit, Investigational, Vet Approved
FexofenadinePseudoephedrine may decrease the sedative activities of Fexofenadine.Approved
FlunarizinePseudoephedrine may decrease the sedative activities of Flunarizine.Approved
FluoxetineThe metabolism of Pseudoephedrine can be decreased when combined with Fluoxetine.Approved, Vet Approved
FlupentixolFlupentixol may decrease the stimulatory activities of Pseudoephedrine.Approved, Withdrawn
FluphenazineFluphenazine may decrease the stimulatory activities of Pseudoephedrine.Approved
FluspirileneFluspirilene may decrease the stimulatory activities of Pseudoephedrine.Approved
FluvoxamineThe metabolism of Pseudoephedrine can be decreased when combined with Fluvoxamine.Approved, Investigational
FurazolidoneFurazolidone may increase the hypertensive activities of Pseudoephedrine.Approved, Vet Approved
Glutamic AcidThe serum concentration of Pseudoephedrine can be decreased when it is combined with L-Glutamic Acid.Approved, Nutraceutical
GuanethidineThe serum concentration of Pseudoephedrine can be decreased when it is combined with Guanethidine.Approved
HaloperidolThe metabolism of Pseudoephedrine can be decreased when combined with Haloperidol.Approved
HeroinPseudoephedrine may increase the analgesic activities of Heroin.Approved, Illicit
HydracarbazineHydracarbazine may increase the hypertensive activities of Pseudoephedrine.Experimental
HydrocodonePseudoephedrine may increase the analgesic activities of Hydrocodone.Approved, Illicit
HydromorphonePseudoephedrine may increase the analgesic activities of Hydromorphone.Approved, Illicit
HydroxyamphetamineThe risk or severity of adverse effects can be increased when Hydroxyamphetamine hydrobromide is combined with Pseudoephedrine.Approved
HydroxyzinePseudoephedrine may decrease the sedative activities of Hydroxyzine.Approved
IloperidoneIloperidone may decrease the stimulatory activities of Pseudoephedrine.Approved
ImipramineImipramine may decrease the antihypertensive activities of Pseudoephedrine.Approved
IndenololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Indenolol.Withdrawn
IndinavirThe metabolism of Pseudoephedrine can be decreased when combined with Indinavir.Approved
IndoraminIndoramin may decrease the vasoconstricting activities of Pseudoephedrine.Withdrawn
IobenguaneThe therapeutic efficacy of Iobenguane can be decreased when used in combination with Pseudoephedrine.Approved
Ioflupane I-123Pseudoephedrine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.Approved
IproclozideIproclozide may increase the hypertensive activities of Pseudoephedrine.Withdrawn
IproniazidIproniazid may increase the hypertensive activities of Pseudoephedrine.Withdrawn
IsocarboxazidIsocarboxazid may increase the hypertensive activities of Pseudoephedrine.Approved
IsoniazidThe metabolism of Pseudoephedrine can be decreased when combined with Isoniazid.Approved
IsoprenalineThe risk or severity of adverse effects can be increased when Isoprenaline is combined with Pseudoephedrine.Approved
IsothipendylPseudoephedrine may decrease the sedative activities of Isothipendyl.Approved
IsoxsuprineThe risk or severity of adverse effects can be increased when Isoxsuprine is combined with Pseudoephedrine.Approved, Withdrawn
KetobemidonePseudoephedrine may increase the analgesic activities of Ketobemidone.Approved
KetoconazoleThe metabolism of Pseudoephedrine can be decreased when combined with Ketoconazole.Approved, Investigational
KetotifenPseudoephedrine may decrease the sedative activities of Ketotifen.Approved
LabetalolPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Labetalol.Approved
LandiololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Aop200704.Investigational
LevocabastinePseudoephedrine may decrease the sedative activities of Levocabastine.Approved
LevocetirizinePseudoephedrine may decrease the sedative activities of Levocetirizine.Approved
Levomethadyl AcetatePseudoephedrine may increase the analgesic activities of Levomethadyl Acetate.Approved
LevomilnacipranLevomilnacipran may increase the tachycardic activities of Pseudoephedrine.Approved
LevorphanolPseudoephedrine may increase the analgesic activities of Levorphanol.Approved
LinezolidLinezolid may increase the hypertensive activities of Pseudoephedrine.Approved, Investigational
LithiumLithium may decrease the stimulatory activities of Pseudoephedrine.Approved
LodoxamidePseudoephedrine may decrease the sedative activities of Lodoxamide.Approved
LofentanilPseudoephedrine may increase the analgesic activities of Lofentanil.Illicit
LopinavirThe metabolism of Pseudoephedrine can be decreased when combined with Lopinavir.Approved
LoratadinePseudoephedrine may decrease the sedative activities of Loratadine.Approved
LorcaserinThe metabolism of Pseudoephedrine can be decreased when combined with Lorcaserin.Approved
LoxapineLoxapine may decrease the stimulatory activities of Pseudoephedrine.Approved
LumefantrineThe metabolism of Pseudoephedrine can be decreased when combined with Lumefantrine.Approved
LurasidoneLurasidone may decrease the stimulatory activities of Pseudoephedrine.Approved
MagaldrateMagaldrate may decrease the excretion rate of Pseudoephedrine which could result in a higher serum level.Withdrawn
Magnesium carbonateMagnesium carbonate may decrease the excretion rate of Pseudoephedrine which could result in a higher serum level.Approved
Magnesium HydroxideMagnesium hydroxide may decrease the excretion rate of Pseudoephedrine which could result in a higher serum level.Approved
Magnesium oxideMagnesium oxide may decrease the excretion rate of Pseudoephedrine which could result in a higher serum level.Approved
Magnesium TrisilicateMagnesium Trisilicate may decrease the excretion rate of Pseudoephedrine which could result in a higher serum level.Approved
MebanazineMebanazine may increase the hypertensive activities of Pseudoephedrine.Withdrawn
MeclizinePseudoephedrine may decrease the sedative activities of Meclizine.Approved
MelperoneMelperone may decrease the stimulatory activities of Pseudoephedrine.Approved
MephentermineThe risk or severity of adverse effects can be increased when Mephentermine is combined with Pseudoephedrine.Approved
MepyraminePseudoephedrine may decrease the sedative activities of Mepyramine.Approved, Vet Approved
MequitazinePseudoephedrine may decrease the sedative activities of Mequitazine.Approved
MesoridazineMesoridazine may decrease the stimulatory activities of Pseudoephedrine.Approved
MetaraminolThe risk or severity of adverse effects can be increased when Metaraminol is combined with Pseudoephedrine.Approved, Investigational
MethadoneThe metabolism of Pseudoephedrine can be decreased when combined with Methadone.Approved
Methadyl AcetatePseudoephedrine may increase the analgesic activities of Methadyl Acetate.Approved, Illicit
MethamphetamineThe risk or severity of adverse effects can be increased when Methamphetamine is combined with Pseudoephedrine.Approved, Illicit
MethapyrilenePseudoephedrine may decrease the sedative activities of Methapyrilene.Withdrawn
MethazolamideMethazolamide may decrease the excretion rate of Pseudoephedrine which could result in a higher serum level.Approved
MethenamineThe serum concentration of Pseudoephedrine can be decreased when it is combined with Hexamethylenetetramine.Approved, Vet Approved
MethotrimeprazineThe metabolism of Pseudoephedrine can be decreased when combined with Methotrimeprazine.Approved
MethoxamineThe risk or severity of adverse effects can be increased when Methoxamine is combined with Pseudoephedrine.Approved
Methylene blueMethylene blue may increase the hypertensive activities of Pseudoephedrine.Investigational
MetiamidePseudoephedrine may decrease the sedative activities of Metiamide.Experimental
MetoprololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Metoprolol.Approved, Investigational
MianserinThe therapeutic efficacy of Pseudoephedrine can be decreased when used in combination with Mianserin.Approved
MidodrineThe risk or severity of adverse effects can be increased when Midodrine is combined with Pseudoephedrine.Approved
MilnacipranMilnacipran may increase the tachycardic activities of Pseudoephedrine.Approved
MinaprineMinaprine may increase the hypertensive activities of Pseudoephedrine.Approved
MirabegronThe metabolism of Pseudoephedrine can be decreased when combined with Mirabegron.Approved
MirtazapineMirtazapine may decrease the antihypertensive activities of Pseudoephedrine.Approved
MizolastinePseudoephedrine may decrease the sedative activities of Mizolastine.Investigational
MoclobemideMoclobemide may increase the hypertensive activities of Pseudoephedrine.Approved
MolindoneMolindone may decrease the stimulatory activities of Pseudoephedrine.Approved
MorphinePseudoephedrine may increase the analgesic activities of Morphine.Approved, Investigational
NabiloneNabilone may increase the tachycardic activities of Pseudoephedrine.Approved, Investigational
NadololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Nadolol.Approved
NalbuphinePseudoephedrine may increase the analgesic activities of Nalbuphine.Approved
NevirapineThe metabolism of Pseudoephedrine can be decreased when combined with Nevirapine.Approved
NialamideNialamide may increase the hypertensive activities of Pseudoephedrine.Withdrawn
NicardipineThe metabolism of Pseudoephedrine can be decreased when combined with Nicardipine.Approved
NilotinibThe metabolism of Pseudoephedrine can be decreased when combined with Nilotinib.Approved, Investigational
NizatidinePseudoephedrine may decrease the sedative activities of Nizatidine.Approved
NorepinephrineThe risk or severity of adverse effects can be increased when Norepinephrine is combined with Pseudoephedrine.Approved
NormethadonePseudoephedrine may increase the analgesic activities of Normethadone.Approved, Illicit
NortriptylineNortriptyline may decrease the antihypertensive activities of Pseudoephedrine.Approved
NylidrinThe risk or severity of adverse effects can be increased when Nylidrin is combined with Pseudoephedrine.Approved
OctamoxinOctamoxin may increase the hypertensive activities of Pseudoephedrine.Withdrawn
OlanzapineOlanzapine may decrease the stimulatory activities of Pseudoephedrine.Approved, Investigational
OlopatadinePseudoephedrine may decrease the sedative activities of Olopatadine.Approved
OndansetronOndansetron may decrease the stimulatory activities of Pseudoephedrine.Approved
OpipramolOpipramol may decrease the antihypertensive activities of Pseudoephedrine.Investigational
OpiumPseudoephedrine may increase the analgesic activities of Opium.Approved, Illicit
OrciprenalineThe risk or severity of adverse effects can be increased when Orciprenaline is combined with Pseudoephedrine.Approved
OsanetantOsanetant may decrease the stimulatory activities of Pseudoephedrine.Investigational
OxprenololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Oxprenolol.Approved
OxycodonePseudoephedrine may increase the analgesic activities of Oxycodone.Approved, Illicit, Investigational
OxymetazolineThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Pseudoephedrine.Approved
OxymorphonePseudoephedrine may increase the analgesic activities of Oxymorphone.Approved, Investigational, Vet Approved
OzagrelPseudoephedrine may decrease the sedative activities of Kct 0809.Investigational
PaliperidonePaliperidone may decrease the stimulatory activities of Pseudoephedrine.Approved
PanobinostatThe serum concentration of Pseudoephedrine can be increased when it is combined with Panobinostat.Approved, Investigational
PargylinePargyline may increase the hypertensive activities of Pseudoephedrine.Approved
ParoxetineThe metabolism of Pseudoephedrine can be decreased when combined with Paroxetine.Approved, Investigational
Peginterferon alfa-2bThe serum concentration of Pseudoephedrine can be decreased when it is combined with Peginterferon alfa-2b.Approved
PemirolastPseudoephedrine may decrease the sedative activities of Pemirolast.Approved
PenbutololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Penbutolol.Approved, Investigational
PentazocinePseudoephedrine may increase the analgesic activities of Pentazocine.Approved, Vet Approved
PerazinePerazine may decrease the stimulatory activities of Pseudoephedrine.Investigational
PerospironePerospirone may decrease the stimulatory activities of Pseudoephedrine.Approved
PerphenazinePerphenazine may decrease the stimulatory activities of Pseudoephedrine.Approved
PethidinePseudoephedrine may increase the analgesic activities of Pethidine.Approved
PhenelzinePhenelzine may increase the hypertensive activities of Pseudoephedrine.Approved
PhenindaminePseudoephedrine may decrease the sedative activities of Phenindamine.Approved
PheniprazinePheniprazine may increase the hypertensive activities of Pseudoephedrine.Withdrawn
PheniraminePseudoephedrine may decrease the sedative activities of Pheniramine.Approved
PhenmetrazineThe risk or severity of adverse effects can be increased when Phenmetrazine is combined with Pseudoephedrine.Approved, Illicit
PhenobarbitalThe serum concentration of Phenobarbital can be decreased when it is combined with Pseudoephedrine.Approved
PhenoxypropazinePhenoxypropazine may increase the hypertensive activities of Pseudoephedrine.Withdrawn
PhentermineThe risk or severity of adverse effects can be increased when Phentermine is combined with Pseudoephedrine.Approved, Illicit
PhenylephrineThe risk or severity of adverse effects can be increased when Phenylephrine is combined with Pseudoephedrine.Approved
PhenylpropanolamineThe risk or severity of adverse effects can be increased when Phenylpropanolamine is combined with Pseudoephedrine.Approved, Vet Approved, Withdrawn
PhenytoinThe serum concentration of Phenytoin can be decreased when it is combined with Pseudoephedrine.Approved, Vet Approved
PimozidePimozide may decrease the stimulatory activities of Pseudoephedrine.Approved
PindololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Pindolol.Approved
PipamperonePipamperone may decrease the stimulatory activities of Pseudoephedrine.Approved
PipotiazinePipotiazine may decrease the stimulatory activities of Pseudoephedrine.Approved
PiritramidePseudoephedrine may increase the analgesic activities of Piritramide.Investigational
PirlindolePirlindole may increase the hypertensive activities of Pseudoephedrine.Approved
PivhydrazinePivhydrazine may increase the hypertensive activities of Pseudoephedrine.Withdrawn
PractololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Practolol.Approved
PrazosinPrazosin may decrease the vasoconstricting activities of Pseudoephedrine.Approved
ProcaterolThe risk or severity of adverse effects can be increased when Procaterol is combined with Pseudoephedrine.Approved
ProchlorperazineProchlorperazine may decrease the stimulatory activities of Pseudoephedrine.Approved, Vet Approved
PromazineThe metabolism of Pseudoephedrine can be decreased when combined with Promazine.Approved, Vet Approved
PromethazinePseudoephedrine may decrease the sedative activities of Promethazine.Approved
PropericiazinePropericiazine may decrease the stimulatory activities of Pseudoephedrine.Approved
PropranololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Propranolol.Approved, Investigational
ProthipendylProthipendyl may decrease the stimulatory activities of Pseudoephedrine.Investigational
ProtriptylineProtriptyline may decrease the antihypertensive activities of Pseudoephedrine.Approved
QuetiapineQuetiapine may decrease the stimulatory activities of Pseudoephedrine.Approved
QuinidineThe metabolism of Pseudoephedrine can be decreased when combined with Quinidine.Approved
QuinineThe metabolism of Pseudoephedrine can be decreased when combined with Quinine.Approved
RacepinephrineThe risk or severity of adverse effects can be increased when Racepinephrine is combined with Pseudoephedrine.Approved
RacloprideRaclopride may decrease the stimulatory activities of Pseudoephedrine.Investigational
RanitidinePseudoephedrine may decrease the sedative activities of Ranitidine.Approved
RanolazineThe metabolism of Pseudoephedrine can be decreased when combined with Ranolazine.Approved, Investigational
RasagilineRasagiline may increase the hypertensive activities of Pseudoephedrine.Approved
RemifentanilPseudoephedrine may increase the analgesic activities of Remifentanil.Approved
RemoxiprideRemoxipride may decrease the stimulatory activities of Pseudoephedrine.Approved, Withdrawn
ReserpineReserpine may decrease the stimulatory activities of Pseudoephedrine.Approved
RisperidoneRisperidone may decrease the stimulatory activities of Pseudoephedrine.Approved, Investigational
RitanserinRitanserin may decrease the stimulatory activities of Pseudoephedrine.Investigational
RitodrineThe risk or severity of adverse effects can be increased when Ritodrine is combined with Pseudoephedrine.Approved
RitonavirThe metabolism of Pseudoephedrine can be decreased when combined with Ritonavir.Approved, Investigational
RolapitantThe metabolism of Pseudoephedrine can be decreased when combined with Rolapitant.Approved
RopiniroleThe metabolism of Pseudoephedrine can be decreased when combined with Ropinirole.Approved, Investigational
Roxatidine acetatePseudoephedrine may decrease the sedative activities of Roxatidine acetate.Approved
SafrazineSafrazine may increase the hypertensive activities of Pseudoephedrine.Withdrawn
SelegilineSelegiline may increase the hypertensive activities of Pseudoephedrine.Approved, Investigational, Vet Approved
SertindoleSertindole may decrease the stimulatory activities of Pseudoephedrine.Approved, Withdrawn
SertralineThe metabolism of Pseudoephedrine can be decreased when combined with Sertraline.Approved
SilodosinSilodosin may decrease the vasoconstricting activities of Pseudoephedrine.Approved
SotalolPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Sotalol.Approved
Spaglumic AcidPseudoephedrine may decrease the sedative activities of Spaglumic Acid.Approved
SpironolactoneSpironolactone may decrease the vasoconstricting activities of Pseudoephedrine.Approved
StiripentolThe metabolism of Pseudoephedrine can be decreased when combined with Stiripentol.Approved
SufentanilPseudoephedrine may increase the analgesic activities of Sufentanil.Approved, Investigational
SulpirideSulpiride may decrease the stimulatory activities of Pseudoephedrine.Approved
SynephrineThe risk or severity of adverse effects can be increased when Synephrine is combined with Pseudoephedrine.Experimental
TamsulosinTamsulosin may decrease the vasoconstricting activities of Pseudoephedrine.Approved, Investigational
TapentadolPseudoephedrine may increase the analgesic activities of Tapentadol.Approved
Tedizolid PhosphateTedizolid Phosphate may increase the hypertensive activities of Pseudoephedrine.Approved
TerazosinTerazosin may decrease the vasoconstricting activities of Pseudoephedrine.Approved
TerbinafineThe metabolism of Pseudoephedrine can be decreased when combined with Terbinafine.Approved, Investigational, Vet Approved
TerbutalineThe risk or severity of adverse effects can be increased when Terbutaline is combined with Pseudoephedrine.Approved
TerfenadinePseudoephedrine may decrease the sedative activities of Terfenadine.Withdrawn
TesmilifenePseudoephedrine may decrease the sedative activities of Tesmilifene.Investigational
TetryzolineThe risk or severity of adverse effects can be increased when Tetryzoline is combined with Pseudoephedrine.Approved
ThioproperazineThioproperazine may decrease the stimulatory activities of Pseudoephedrine.Approved
ThioridazineThe metabolism of Pseudoephedrine can be decreased when combined with Thioridazine.Withdrawn
ThiothixeneThiothixene may decrease the stimulatory activities of Pseudoephedrine.Approved
ThonzylaminePseudoephedrine may decrease the sedative activities of Thonzylamine.Approved
TianeptineTianeptine may decrease the antihypertensive activities of Pseudoephedrine.Approved
TiaprideTiapride may decrease the stimulatory activities of Pseudoephedrine.Approved, Investigational
TiclopidineThe metabolism of Pseudoephedrine can be decreased when combined with Ticlopidine.Approved
TimololPseudoephedrine may increase the atrioventricular blocking (AV block) activities of Timolol.Approved
TipranavirThe metabolism of Pseudoephedrine can be decreased when combined with Tipranavir.Approved, Investigational
ToloxatoneToloxatone may increase the hypertensive activities of Pseudoephedrine.Approved
TramadolPseudoephedrine may increase the analgesic activities of Tramadol.Approved, Investigational
TranilastPseudoephedrine may decrease the sedative activities of Tranilast.Approved, Investigational
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the hypertensive activities of Pseudoephedrine.Experimental
TranylcypromineTranylcypromine may increase the hypertensive activities of Pseudoephedrine.Approved
TrifluoperazineTrifluoperazine may decrease the stimulatory activities of Pseudoephedrine.Approved
TriflupromazineTriflupromazine may decrease the stimulatory activities of Pseudoephedrine.Approved, Vet Approved
TrimazosinTrimazosin may decrease the vasoconstricting activities of Pseudoephedrine.Experimental
TrimipramineTrimipramine may decrease the antihypertensive activities of Pseudoephedrine.Approved
TripelennaminePseudoephedrine may decrease the sedative activities of Tripelennamine.Approved, Vet Approved
TriprolidinePseudoephedrine may decrease the sedative activities of Triprolidine.Approved
TyramineThe risk or severity of adverse effects can be increased when Tyramine is combined with Pseudoephedrine.Investigational, Nutraceutical
VenlafaxineVenlafaxine may increase the tachycardic activities of Pseudoephedrine.Approved
Vitamin CThe serum concentration of Pseudoephedrine can be decreased when it is combined with Vitamin C.Approved, Nutraceutical
ZiprasidoneThe metabolism of Pseudoephedrine can be decreased when combined with Ziprasidone.Approved
ZotepineZotepine may decrease the stimulatory activities of Pseudoephedrine.Approved
ZuclopenthixolZuclopenthixol may decrease the stimulatory activities of Pseudoephedrine.Approved, Investigational
Food Interactions
  • Take without regard to meals.

References

Synthesis Reference

Andrew G. Myers, "Synthesis of l-azatyrosine using pseudoephedrine as a chiral auxiliary." U.S. Patent US5760237, issued June, 1991.

US5760237
General References
Not Available
External Links
Human Metabolome Database
HMDB01943
KEGG Drug
D08449
KEGG Compound
C02765
PubChem Compound
7028
PubChem Substance
46508190
ChemSpider
6761
ChEBI
51209
ChEMBL
CHEMBL1590
Therapeutic Targets Database
DAP000195
PharmGKB
PA451170
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Pseudoephedrine
ATC Codes
R01BA02 — PseudoephedrineR01BA52 — Pseudoephedrine, combinations
AHFS Codes
  • 12:12.12
PDB Entries
Not Available
FDA label
Not Available
MSDS
Download (52.7 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0Active Not RecruitingOtherMultiple System Atrophy (MSA) / Shy-Drager Syndrome1
1CompletedNot AvailableAutonomic Failure / Idiopathic orthostatic hypotension1
1CompletedDiagnosticBMI >30 kg/m2 / Hypertensive / Progressive autonomic failure / Shy-Drager Syndrome1
1CompletedTreatmentHealthy Volunteers5
2CompletedTreatmentAllergic Rhinitis (AR)3
2CompletedTreatmentSeasonal Allergic Rhinitis (SAR)1
2Unknown StatusTreatmentRhinitis, Seasonal, Allergic1
2WithdrawnTreatmentHuman Immunodeficiency Virus (HIV) Infections / Sinusitis1
3CompletedTreatmentNasal Congestion Associated With the Common Cold1
3CompletedTreatmentNasal Congestion and Inflammations / Rhinitis1
3CompletedTreatmentPerennial Allergic Rhinitis (PAR)1
3CompletedTreatmentAcute Rhinitis / Pharyngitis1
3CompletedTreatmentRhinitis, Allergic, Perennial1
3CompletedTreatmentRhinitis, Allergic, Seasonal1
3CompletedTreatmentSeasonal Rhinitis1
3CompletedTreatmentVasomotor Rhinitis1
3CompletedTreatmentAcute Rhinitis1
3Unknown StatusTreatmentViral Infections of the Upper Respiratory Tract1
3WithdrawnTreatmentCoughing / Inflammatory Reaction / Rhinitis1
4CompletedPreventionAcute Upper Respiratory Track Infection1
4CompletedTreatmentAcute Respiratory Infections / Acute Rhinosinusitis1
4CompletedTreatmentAcute maxillary sinusitis caused by M. catarrhalis / Acute Respiratory Infections / Bronchitis1
4CompletedTreatmentAcute Rhinitis / Headaches / Nasal Stuffiness1
4CompletedTreatmentNasal Stuffiness1
Not AvailableCompletedNot AvailableHealthy Volunteers2
Not AvailableCompletedNot AvailableSeasonal Allergic Rhinitis (SAR) / Sinusitis1
Not AvailableCompletedBasic ScienceUrethral Sphincter Activity1
Not AvailableCompletedTreatmentAtopics / Rhinitis1
Not AvailableCompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Sinusitis1
Not AvailableCompletedTreatmentSeasonal Allergic Rhinitis (SAR)1
Not AvailableRecruitingBasic ScienceMiddle Ear Disease / Nasal Allergies1
Not AvailableUnknown StatusTreatmentCoughing1
Not AvailableUnknown StatusTreatmentRhinitis / Sleep1

Pharmacoeconomics

Manufacturers
  • Ucb inc
  • Schering plough healthcare products inc
Packagers
Dosage forms
FormRouteStrength
Tablet, multilayer, extended releaseOral
Capsule, liquid filledOral
Tablet, film coatedOral
SyrupOral7.5 mg
SyrupOral
SolutionOral15 mg/5mL
Tablet, extended releaseOral
Capsule; kitOral
TabletOral30 mg
Capsule, extended releaseOral120 mg
PillOral30 mg/1
Kit; powder, for solutionOral
Tablet; tablet, extended releaseOral
Tablet, extended releaseOral120 mg
LiquidOral60 mg/60mL
Kit; powderOral
SuspensionOral
Tablet, sugar coatedOral
Tablet, film coated, extended releaseOral120 mg/1
PowderOral
SolutionOral
Tablet, coatedOral
Tablet, chewableOral
Tablet, film coated, extended releaseOral
TabletOral120 mg
Capsule, extended releaseOral240 mg
TabletOral
Capsule, gelatin coatedOral30 mg/1
TabletOral30 mg/1
Tablet, film coatedOral30 mg/1
Tablet, sugar coatedOral30 mg/1
LiquidOral
Capsule, extended releaseOral
Solution / dropsOral
Tablet, extended releaseOral120 mg/1
Tablet, film coatedOral120 mg/1
TabletOral60 mg/1
TabletOral60 mg
ElixirOral
Tablet, multilayerOral
CapsuleOral
LiquidOral30 mg/5mL
Tablet, extended releaseOral240 mg/1
TabletOral15 mg
SyrupOral30 mg
LiquidOral15 mg/5mL
Tablet, coatedOral30 mg/1
Tablet, film coatedOral60 mg/1
Powder, for solutionOral
Kit; tabletOral
LiquidOral30 mg
LiquidOral7.5 mg
Prices
Unit descriptionCostUnit
Sudafed 24 hour tablet0.84USD tablet
Pseudoephedrine hcl crystal0.67USD g
Afrin 0.05% nose spray0.62USD ml
Sudafed 12 hr sinus-pain caplet0.53USD caplet
Drixoral cold & allergy tablet sa0.4USD tablet
Sudafed om sinus nasal spray0.4USD ml
Afrin no drip sinus pump mist0.38USD ml
Sudafed pe cold & cough caplet0.34USD caplet
Afrin sinus spray0.33USD ml
Chlor-trimeton allergy0.31USD each
Sudafed pe severe cold caplet0.28USD caplet
Guaifenesin-phenylephrine tablet0.27USD tablet
Dimetapp cold-allergy tablet chew0.25USD tablet
Sudafed pe 10 mg tablet0.25USD tablet
Chlor-trimeton 8 mg repetab0.24USD tablet
Sudafed pe day & night tablet0.24USD tablet
Sudafed triple action caplet0.23USD caplet
Sudafed pe nighttime cold caplet0.22USD caplet
Sudafed non-drying sinus caplet0.2USD caplet
Sudafed pe sinus & allergy tablet0.2USD tablet
Sudafed pe sinus headache caplet0.2USD caplet
Sudafed 30 mg tablet0.19USD tablet
Wal-phed 30 mg tablet0.17USD tablet
Suphedrin 30 mg tablet0.15USD tablet
CVS Pharmacy decongestant 30 mg tablet0.12USD tablet
Sudogest 60 mg tablet0.12USD tablet
Medi-phedrine 30 mg tablet0.1USD tablet
Nasal decongestant 30 mg tablet0.1USD tablet
Genaphed plus tablet0.09USD tablet
CVS Pharmacy nasal decongest 30 mg tablet0.07USD tablet
Genaphed 30 mg tablet0.07USD tablet
Pseudoephedrine gg syrup0.07USD ml
Pseudoephedrine 60 mg tablet0.06USD tablet
Children's sudafed pe liquid0.05USD ml
Pseudoephedrine 30 mg tablet0.05USD tablet
Dimetapp cold & cough liquid0.04USD ml
Dimetapp dm cold & cough elix0.04USD ml
Dimetapp long-acting cough liquid0.04USD ml
Suphedrine 30 mg tablet0.04USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6037353 Yes1997-09-142017-09-14Us
US6039974 No1998-07-312018-07-31Us
US6211246 No1999-06-102019-06-10Us
US6469009 No1999-07-132019-07-13Us
US7226614 No2002-06-102022-06-10Us
US6489329 No1996-04-082016-04-08Us
US7014867 No2002-06-102022-06-10Us
US6100274 Yes2000-01-072020-01-07Us
US6372252 No2000-04-282020-04-28Us
US6955821 No2000-04-282020-04-28Us
US7838032 No2000-04-282020-04-28Us
US7618649 Yes2001-06-192021-06-19Us
US6709676 No2001-02-182021-02-18Us
US8187630 No2000-12-192020-12-19Us
US7863287 No2007-02-282027-02-28Us
US6979463 No2002-03-282022-03-28Us
US7820199 Yes2002-09-282022-09-28Us
US6613357 No2000-12-252020-12-25Us
USRE39069 No1998-05-292018-05-29Us
US6113942 Yes1995-08-282015-08-28Us
US5855912 Yes1995-08-282015-08-28Us

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)119 °CPhysProp
water solubility7 mg/LNot Available
logP0.89KRIL,MB & FUNG,HL (1990)
pKa10.3 (at 0 °C)PERRIN,DD (1965)
Predicted Properties
PropertyValueSource
Water Solubility8.26 mg/mLALOGPS
logP1ALOGPS
logP1.32ChemAxon
logS-1.3ALOGPS
pKa (Strongest Acidic)13.89ChemAxon
pKa (Strongest Basic)9.52ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area32.26 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity49.69 m3·mol-1ChemAxon
Polarizability18.83 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9645
Blood Brain Barrier+0.5638
Caco-2 permeable+0.8866
P-glycoprotein substrateNon-substrate0.7182
P-glycoprotein inhibitor INon-inhibitor0.9795
P-glycoprotein inhibitor IINon-inhibitor0.984
Renal organic cation transporterNon-inhibitor0.8965
CYP450 2C9 substrateNon-substrate0.8001
CYP450 2D6 substrateNon-substrate0.7839
CYP450 3A4 substrateNon-substrate0.7235
CYP450 1A2 substrateNon-inhibitor0.5595
CYP450 2C9 inhibitorNon-inhibitor0.7209
CYP450 2D6 inhibitorInhibitor0.5846
CYP450 2C19 inhibitorNon-inhibitor0.5737
CYP450 3A4 inhibitorNon-inhibitor0.9431
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.907
Ames testNon AMES toxic0.9517
CarcinogenicityNon-carcinogens0.7739
BiodegradationNot ready biodegradable0.7807
Rat acute toxicity2.3882 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9329
hERG inhibition (predictor II)Non-inhibitor0.9277
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )

Spectra

Mass Spec (NIST)
Download (8.24 KB)
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
LC-MS/MS Spectrum - Quattro_QQQ 10V, N/A (Annotated)LC-MS/MSsplash10-016s-3900000000-868bf4bba93d8b4be696
LC-MS/MS Spectrum - Quattro_QQQ 25V, N/A (Annotated)LC-MS/MSsplash10-0159-2900000000-6c55fc67b7576cb42a8a
LC-MS/MS Spectrum - Quattro_QQQ 40V, N/A (Annotated)LC-MS/MSsplash10-0006-9700000000-459686cbaf7d3b59c202
Predicted LC-MS/MS Spectrum - 10V, PositivePredicted LC-MS/MSNot Available
Predicted LC-MS/MS Spectrum - 20V, PositivePredicted LC-MS/MSNot Available
Predicted LC-MS/MS Spectrum - 40V, PositivePredicted LC-MS/MSNot Available
Predicted LC-MS/MS Spectrum - 10V, NegativePredicted LC-MS/MSNot Available
Predicted LC-MS/MS Spectrum - 20V, NegativePredicted LC-MS/MSNot Available
Predicted LC-MS/MS Spectrum - 40V, NegativePredicted LC-MS/MSNot Available
Mass Spectrum (Electron Ionization)MSsplash10-0a4i-9000000000-8f0484f72b48017f1f2e
1H NMR Spectrum1D NMRNot applicable
[1H,13C] 2D NMR Spectrum2D NMRNot applicable

Taxonomy

Description
This compound belongs to the class of chemical entities known as phenylpropanes. These are organic compounds containing a phenylpropane moiety.
Kingdom
Chemical entities
Super Class
Organic compounds
Class
Benzenoids
Sub Class
Benzene and substituted derivatives
Direct Parent
Phenylpropanes
Alternative Parents
Aralkylamines / Secondary alcohols / 1,2-aminoalcohols / Dialkylamines / Organopnictogen compounds / Hydrocarbon derivatives / Aromatic alcohols
Substituents
Phenylpropane / Aralkylamine / 1,2-aminoalcohol / Secondary alcohol / Secondary aliphatic amine / Secondary amine / Alcohol / Organopnictogen compound / Organic oxygen compound / Organooxygen compound
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
secondary alcohol, secondary amine (CHEBI:51209 ) / Phenylalanine derived alkaloids (C02765 )

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Norepinephrine:sodium symporter activity
Specific Function
Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name
SLC6A2
Uniprot ID
P23975
Uniprot Name
Sodium-dependent noradrenaline transporter
Molecular Weight
69331.42 Da
References
  1. Wee S, Ordway GA, Woolverton WL: Reinforcing effect of pseudoephedrine isomers and the mechanism of action. Eur J Pharmacol. 2004 Jun 16;493(1-3):117-25. [PubMed:15189772 ]
  2. Foley KF, Van Dort ME, Sievert MK, Ruoho AE, Cozzi NV: Stereospecific inhibition of monoamine uptake transporters by meta-hydroxyephedrine isomers. J Neural Transm (Vienna). 2002 Oct;109(10):1229-40. [PubMed:12373557 ]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Monoamine transmembrane transporter activity
Specific Function
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name
SLC6A3
Uniprot ID
Q01959
Uniprot Name
Sodium-dependent dopamine transporter
Molecular Weight
68494.255 Da
References
  1. Wee S, Ordway GA, Woolverton WL: Reinforcing effect of pseudoephedrine isomers and the mechanism of action. Eur J Pharmacol. 2004 Jun 16;493(1-3):117-25. [PubMed:15189772 ]
  2. Foley KF, Van Dort ME, Sievert MK, Ruoho AE, Cozzi NV: Stereospecific inhibition of monoamine uptake transporters by meta-hydroxyephedrine isomers. J Neural Transm (Vienna). 2002 Oct;109(10):1229-40. [PubMed:12373557 ]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Agonist
General Function
Protein heterodimerization activity
Specific Function
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) prot...
Gene Name
ADRA1A
Uniprot ID
P35348
Uniprot Name
Alpha-1A adrenergic receptor
Molecular Weight
51486.005 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Wellington K, Jarvis B: Cetirizine/pseudoephedrine. Drugs. 2001;61(15):2231-40; discussion 2241-2. [PubMed:11772135 ]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Agonist
General Function
Thioesterase binding
Specific Function
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazo...
Gene Name
ADRA2A
Uniprot ID
P08913
Uniprot Name
Alpha-2A adrenergic receptor
Molecular Weight
48956.275 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Serotonin:sodium symporter activity
Specific Function
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into t...
Gene Name
SLC6A4
Uniprot ID
P31645
Uniprot Name
Sodium-dependent serotonin transporter
Molecular Weight
70324.165 Da
References
  1. Wee S, Ordway GA, Woolverton WL: Reinforcing effect of pseudoephedrine isomers and the mechanism of action. Eur J Pharmacol. 2004 Jun 16;493(1-3):117-25. [PubMed:15189772 ]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Partial agonist
General Function
Protein homodimerization activity
Specific Function
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately ...
Gene Name
ADRB2
Uniprot ID
P07550
Uniprot Name
Beta-2 adrenergic receptor
Molecular Weight
46458.32 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Vansal SS, Feller DR: Direct effects of ephedrine isomers on human beta-adrenergic receptor subtypes. Biochem Pharmacol. 1999 Sep 1;58(5):807-10. [PubMed:10449190 ]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Agonist
Partial agonist
General Function
Receptor signaling protein activity
Specific Function
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately e...
Gene Name
ADRB1
Uniprot ID
P08588
Uniprot Name
Beta-1 adrenergic receptor
Molecular Weight
51322.1 Da
References
  1. Vansal SS, Feller DR: Direct effects of ephedrine isomers on human beta-adrenergic receptor subtypes. Biochem Pharmacol. 1999 Sep 1;58(5):807-10. [PubMed:10449190 ]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Transcriptional activator activity, rna polymerase ii distal enhancer sequence-specific binding
Specific Function
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. ...
Gene Name
NFATC1
Uniprot ID
O95644
Uniprot Name
Nuclear factor of activated T-cells, cytoplasmic 1
Molecular Weight
101241.73 Da
References
  1. Fiebich BL, Collado JA, Stratz C, Valina C, Hochholzer W, Munoz E, Bellido LM: Pseudoephedrine inhibits T-cell activation by targeting NF-kappaB, NFAT and AP-1 signaling pathways. Immunopharmacol Immunotoxicol. 2012 Feb;34(1):98-106. doi: 10.3109/08923973.2011.582118. Epub 2011 Jun 2. [PubMed:21631396 ]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Tumor necrosis factor receptor binding
Specific Function
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct ac...
Gene Name
TNF
Uniprot ID
P01375
Uniprot Name
Tumor necrosis factor
Molecular Weight
25644.15 Da
References
  1. Wu Z, Kong X, Zhang T, Ye J, Fang Z, Yang X: Pseudoephedrine/ephedrine shows potent anti-inflammatory activity against TNF-alpha-mediated acute liver failure induced by lipopolysaccharide/D-galactosamine. Eur J Pharmacol. 2014 Feb 5;724:112-21. doi: 10.1016/j.ejphar.2013.11.032. Epub 2013 Dec 21. [PubMed:24365491 ]
  2. Fiebich BL, Collado JA, Stratz C, Valina C, Hochholzer W, Munoz E, Bellido LM: Pseudoephedrine inhibits T-cell activation by targeting NF-kappaB, NFAT and AP-1 signaling pathways. Immunopharmacol Immunotoxicol. 2012 Feb;34(1):98-106. doi: 10.3109/08923973.2011.582118. Epub 2011 Jun 2. [PubMed:21631396 ]
10. Nuclear factor kappa-light-chain-enhancer of activated B cells
Kind
Protein
Organism
Human
Pharmacological action
Unknown
References
  1. Fiebich BL, Collado JA, Stratz C, Valina C, Hochholzer W, Munoz E, Bellido LM: Pseudoephedrine inhibits T-cell activation by targeting NF-kappaB, NFAT and AP-1 signaling pathways. Immunopharmacol Immunotoxicol. 2012 Feb;34(1):98-106. doi: 10.3109/08923973.2011.582118. Epub 2011 Jun 2. [PubMed:21631396 ]
Kind
Protein group
Organism
Human
Pharmacological action
Unknown
General Function
Transcriptional activator activity, rna polymerase ii transcription regulatory region sequence-specific binding
Specific Function
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. ...

Components:
References
  1. Fiebich BL, Collado JA, Stratz C, Valina C, Hochholzer W, Munoz E, Bellido LM: Pseudoephedrine inhibits T-cell activation by targeting NF-kappaB, NFAT and AP-1 signaling pathways. Immunopharmacol Immunotoxicol. 2012 Feb;34(1):98-106. doi: 10.3109/08923973.2011.582118. Epub 2011 Jun 2. [PubMed:21631396 ]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Kinase activator activity
Specific Function
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimu...
Gene Name
IL2
Uniprot ID
P60568
Uniprot Name
Interleukin-2
Molecular Weight
17627.52 Da
References
  1. Fiebich BL, Collado JA, Stratz C, Valina C, Hochholzer W, Munoz E, Bellido LM: Pseudoephedrine inhibits T-cell activation by targeting NF-kappaB, NFAT and AP-1 signaling pathways. Immunopharmacol Immunotoxicol. 2012 Feb;34(1):98-106. doi: 10.3109/08923973.2011.582118. Epub 2011 Jun 2. [PubMed:21631396 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Serotonin binding
Specific Function
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral...
Gene Name
MAOA
Uniprot ID
P21397
Uniprot Name
Amine oxidase [flavin-containing] A
Molecular Weight
59681.27 Da
References
  1. Ulus IH, Maher TJ, Wurtman RJ: Characterization of phentermine and related compounds as monoamine oxidase (MAO) inhibitors. Biochem Pharmacol. 2000 Jun 15;59(12):1611-21. [PubMed:10799660 ]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...
Gene Name
CYP2D6
Uniprot ID
P10635
Uniprot Name
Cytochrome P450 2D6
Molecular Weight
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Drug created on June 13, 2005 07:24 / Updated on September 01, 2017 10:33