Structure and sequence of the rfb (O antigen) gene cluster of Salmonella serovar typhimurium (strain LT2).

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Jiang XM, Neal B, Santiago F, Lee SJ, Romana LK, Reeves PR

Structure and sequence of the rfb (O antigen) gene cluster of Salmonella serovar typhimurium (strain LT2).

Mol Microbiol. 1991 Mar;5(3):695-713.

PubMed ID
1710759 [ View in PubMed
]
Abstract

The rfb gene cluster of Salmonella LT2 has been cloned and sequenced. The genes rfbA, rfbB, rfbD, rfbF, rfbG, rfbK, rfbM and rfbP were located individually and the gene rfbL was located outside the cluster. Approximately 16 open reading frames were found in the region which is essential for the expression of O antigen. The gene products of rfbB and rfbG were found to have homology with the group of dehydrogenase and related enzymes described previously. Analysis of the G + C ratio of the rfb cluster extended the area of low-G + C composition previously found in the sequence of rfbJ to the whole rfb gene cluster. Three to five segments with discrete G + C contents and codon adaptation indices are present in the rfb region, indicating a heterogeneous origin of these segments. Potential promoters were found near the start of the rfb region, supporting the possibility that the rfb gene cluster is an operon.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
dTDP-4-dehydrorhamnose 3,5-epimeraseP26394Details
CDP-glucose 4,6-dehydrataseP26397Details
dTDP-glucose 4,6-dehydrataseP26391Details
Glucose-1-phosphate thymidylyltransferaseP26393Details
dTDP-4-dehydrorhamnose reductaseP26392Details
Glucose-1-phosphate cytidylyltransferaseP26396Details