- Accession Number
A class of compounds named after and generally derived from C20 fatty acids (EICOSANOIC ACIDS) that includes PROSTAGLANDINS; LEUKOTRIENES; THROMBOXANES, and HYDROXYEICOSATETRAENOIC ACIDS. They have hormone-like effects mediated by specialized receptors (RECEPTORS, EICOSANOID).
Drug Drug Description Dihomo-gamma-linolenic acid For nutritional supplementation, also for treating dietary shortage or imbalance Icosapent A polyunsaturated fatty acid, usually found in fish oils, that is used in many supplements. Travoprost A prostaglandin analog used in the treatment of elevated intraocular pressure due to open angle glaucoma or ocular hypertension. Treprostinil A prostacyclin vasodilator for the treatment of pulmonary arterial hypertension to relieve exercise associated symptoms and to prevent clinical deterioration after stopping epoprostenol. Carboprost tromethamine A prostaglandin used to treat postpartum uterine hemorrhage due to atony when other methods of management have not been effective. Latanoprost An isopropyl ester prodrug used to treat increased intraocular pressure. Alprostadil A medication used to treat erectile dysfunction. Bimatoprost A prostaglandin analog used to treat hypotrichosis of the eyelashes and intraocular pressure in open angle glaucoma or ocular hypertension. Dinoprostone A prostaglandin used to induce labor or abortion as well as to treat nonmetastatic gestational trophoblastic disease. Misoprostol A prostaglandin E1 analogue used to reduce the risk of NSAID-induced gastric ulcers. Lubiprostone A prostaglandin derivative used to treat constipation caused by irritable bowel syndrome and opioid-use. Iloprost A synthetic prostacyclin analog indicated to treat pulmonary arterial hypertension (PAH). Dinoprost tromethamine Used for aborting second-trimester pregnancy (between the twelfth to eighteenth week of gestation) and in incomplete abortion or for therapeutic abortion in cases of intrauterine fetal death and congenital abnormalities... Epoprostenol A vasodilator and platelet aggregation inhibitor used for the management of primary pulmonary hypertension and pulmonary hypertension in patients with heart failure. Prostaglandin B2 Not Available Prostaglandin G2 A cyclic endoperoxide intermediate produced by the action of CYCLOOXYGENASE on ARACHIDONIC ACID. It is further converted by a series of specific enzymes to the series 2 prostaglandins. [PubChem] Arachidonic Acid An unsaturated, essential fatty acid. It is found in animal and human fat as well as in the liver, brain, and glandular organs, and is a constituent of animal phosphatides.... Beraprost For the treatment of pulmonary hypertension. Cobiprostone Investigated for use/treatment in cystic fibrosis. Unoprostone A prostaglandin analogue used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension who are clinically unresponsive to other ocular antihypertensive agents. Tafluprost An ophthalmic prostaglandin analog used to lower intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Leukotriene C4 The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates... Icosapent ethyl An ethyl ester of eicosapentaenoic acid (EPA) that reduces synthesis and enhances clearance of triglycerides that is used to treat patients with severe hypertriglyceridemia. Gemeprost Indicated for the softening and dilatation of the cervix uteri prior to transcervical, intrauterine operative procedures in the first trimester of pregnancy or facilitating therapeutic termination of pregnancy in patients... Limaprost Limaprost is used for the improvement of various ischemic symptoms such as ulcer, pain and feeling of coldness associated with thromboangiitis obliterans as well as improvement of subjective symptoms (pain... Omega-3-acid ethyl esters A mixture of fatty acids used as an adjunct to diet to reduce triglyceride (TG) levels in adult patients with severe hypertriglyceridemia. Fenprostalene Not Annotated Luprostiol Not Annotated Prostalene Analog of prostaglandin F2 alpha. Cloprostenol Not Annotated Fluprostenol Not Annotated Latanoprostene bunod A prostaglandin analog used to reduce ocular hypertension or treat open-angle glaucoma. Leukotriene D4 Leukotriene D4 has been used in trials studying the diagnostic of Asthma and Allergic Rhinitis. Sulprostone Sulprostone has been used in trials studying Abortion, Induced. Dinoprost A medication used to induce a second trimester abortion. Leukotriene B4 Leukotriene B4 has been used in trials studying the treatment of HIV Infections. Resolvin E1 Resolvin E1 (RX 10001) is under investigation in clinical trial NCT00941018 (Single and Multiple Ascending Oral Dose Study of Resolvin E1 in Healthy Volunteers). Enprostil Not Annotated Prostaglandin D2 The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesized by alveolar macrophages. Among its many biological actions, the most important... Methoxy arachidonyl fluorophosphonate Methoxy arachidonyl fluorophosphonate, commonly referred as MAFP, is an irreversible active site-directed enzyme inhibitor that inhibits nearly all serine hydrolases and serine proteases. It inhibits phospholipase A2 and fatty acid... Edasalonexent Edasalonexent is under investigation in clinical trial NCT01511900 (A Multiple Ascending Dose Study of CAT-1004 in Patients With Type 2 Diabetes).
- Drugs & Drug Targets