Inflammation Mediators

Name
Inflammation Mediators
Accession Number
DBCAT000352
Description

The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).

Drugs
DrugDrug Description
Dihomo-gamma-linolenic acidFor nutritional supplementation, also for treating dietary shortage or imbalance
IcosapentA polyunsaturated fatty acid, usually found in fish oils, that is used in many supplements.
TreprostinilA prostacyclin vasodilator for the treatment of pulmonary arterial hypertension to relieve exercise associated symptoms and to prevent clinical deterioration after stopping epoprostenol.
Carboprost tromethamineA prostaglandin used to treat postpartum uterine hemorrhage due to atony when other methods of management have not been effective.
AlprostadilA medication used to treat erectile dysfunction.
BimatoprostA prostaglandin analog used to treat hypotrichosis of the eyelashes and intraocular pressure in open angle glaucoma or ocular hypertension.
DinoprostoneA prostaglandin used to induce labor or abortion as well as to treat nonmetastatic gestational trophoblastic disease.
MisoprostolA prostaglandin E1 analogue used to reduce the risk of NSAID-induced gastric ulcers.
LubiprostoneA prostaglandin derivative used to treat constipation caused by irritable bowel syndrome and opioid-use.
IloprostA synthetic prostacyclin analog indicated to treat pulmonary arterial hypertension (PAH).
Dinoprost tromethamineUsed for aborting second-trimester pregnancy (between the twelfth to eighteenth week of gestation) and in incomplete abortion or for therapeutic abortion in cases of intrauterine fetal death and congenital abnormalities...
EpoprostenolA vasodilator and platelet aggregation inhibitor used for the management of primary pulmonary hypertension and pulmonary hypertension in patients with heart failure.
5-Methoxy-N,N-diisopropyltryptamine5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) is a tryptamine derivative and shares many similarities with schedule I tryptamine hallucinogens such as alpha-ethyltryptamine, N,N-dimethyltryptamine, N,N-diethyltryptamine, bufotenine, psilocybin and psilocin. Since 1999, there has been a...
BufotenineA hallucinogenic serotonin analog found in frog or toad skins, mushrooms, higher plants, and mammals, especially in the brains, plasma, and urine of schizophrenics. Bufotenin has been used as a...
Platelet Activating FactorNot Available
Prostaglandin B2Not Available
Prostaglandin G2A cyclic endoperoxide intermediate produced by the action of CYCLOOXYGENASE on ARACHIDONIC ACID. It is further converted by a series of specific enzymes to the series 2 prostaglandins. [PubChem]
Arachidonic AcidAn unsaturated, essential fatty acid. It is found in animal and human fat as well as in the liver, brain, and glandular organs, and is a constituent of animal phosphatides....
N-acetylhistamineNot Available
BeraprostFor the treatment of pulmonary hypertension.
HistamineAn ingredient of topical drugs for the relief of joint pain or muscle aches and pains.
CobiprostoneInvestigated for use/treatment in cystic fibrosis.
CTCE-0214Investigated for use/treatment in adverse effects (chemotherapy), blood (blood forming organ disorders, unspecified), cancer/tumors (unspecified), neutropenics, and vascular diseases.
IcatibantA bradykinin B2 receptor antagonist used to treat acute episodes of swelling and inflammation associated with hereditary angioedema (HAE).
LabradimilInvestigated for use/treatment in brain cancer and pediatric indications.
N-chlorotaurineInvestigated for use/treatment in eye disorders/infections.
SaralasinNot Annotated
UnoprostoneA prostaglandin analogue used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension who are clinically unresponsive to other ocular antihypertensive agents.
TafluprostAn ophthalmic prostaglandin analog used to lower intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
SerotoninFor temporary relief of nervousness, anxiety, mood swings, joint pains, weakness, drowsiness, itching and lethargy. Not evaluated by the FDA, homeopathic product.
Leukotriene C4The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates...
Icosapent ethylAn ethyl ester of eicosapentaenoic acid (EPA) that reduces synthesis and enhances clearance of triglycerides that is used to treat patients with severe hypertriglyceridemia.
GemeprostIndicated for the softening and dilatation of the cervix uteri prior to transcervical, intrauterine operative procedures in the first trimester of pregnancy or facilitating therapeutic termination of pregnancy in patients...
LimaprostLimaprost is used for the improvement of various ischemic symptoms such as ulcer, pain and feeling of coldness associated with thromboangiitis obliterans as well as improvement of subjective symptoms (pain...
Omega-3-acid ethyl estersA mixture of fatty acids used as an adjunct to diet to reduce triglyceride (TG) levels in adult patients with severe hypertriglyceridemia.
FenprostaleneNot Annotated
LuprostiolNot Annotated
ProstaleneAnalog of prostaglandin F2 alpha.
CloprostenolNot Annotated
FluprostenolNot Annotated
Latanoprostene bunodA prostaglandin analog used to reduce ocular hypertension or treat open-angle glaucoma.
Angiotensin IIA peptide hormone of the RAAS system used to raise blood pressure in septic or other forms of shock.
Leukotriene D4Leukotriene D4 has been used in trials studying the diagnostic of Asthma and Allergic Rhinitis.
NagrestipenNagrestipen has been used in trials studying the treatment of CANCER, Neoplasm, Metastasis, Radiation Oncology, and Neoplasm Metastasis.
BradykininBradykinin has been investigated for the basic science and treatment of Hypertension and Diabetes Type 2.
SulprostoneSulprostone has been used in trials studying Abortion, Induced.
DinoprostA medication used to induce a second trimester abortion.
Leukotriene B4Leukotriene B4 has been used in trials studying the treatment of HIV Infections.
Resolvin E1Resolvin E1 (RX 10001) is under investigation in clinical trial NCT00941018 (Single and Multiple Ascending Oral Dose Study of Resolvin E1 in Healthy Volunteers).
AngiotensinamideNot Annotated
EnprostilNot Annotated
Prostaglandin D2The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesized by alveolar macrophages. Among its many biological actions, the most important...
N-acetylserotoninNot Available
TravoprostA prostaglandin analog used in the treatment of elevated intraocular pressure due to open angle glaucoma or ocular hypertension.
Methoxy arachidonyl fluorophosphonateMethoxy arachidonyl fluorophosphonate, commonly referred as MAFP, is an irreversible active site-directed enzyme inhibitor that inhibits nearly all serine hydrolases and serine proteases. It inhibits phospholipase A2 and fatty acid...
Sar9, Met (O2)11-Substance PInvestigated for use/treatment in acute respiratory distress syndrome (ARDS) and viral infection.
Angiotensin 1-7TXA127 has been investigated for the treatment of Miscellaneous Peripheral Blood Cell Abnormalities.
AclerastideAclerastide has been investigated for the treatment of Diabetic Foot, Diabetic Foot Ulcers, and Foot Ulcer, Diabetic.
EdasalonexentEdasalonexent is under investigation in clinical trial NCT01511900 (A Multiple Ascending Dose Study of CAT-1004 in Patients With Type 2 Diabetes).
Drugs & Drug Targets
DrugTargetType
Dihomo-gamma-linolenic acidProstaglandin G/H synthase 2target
Dihomo-gamma-linolenic acidProstaglandin G/H synthase 1target
Dihomo-gamma-linolenic acidFatty acid-binding protein, braincarrier
IcosapentProstaglandin G/H synthase 2target
IcosapentProstaglandin G/H synthase 1target
IcosapentFree fatty acid receptor 1target
IcosapentFatty acid-binding protein, braincarrier
IcosapentFatty acid desaturase 1target
IcosapentLong-chain-fatty-acid--CoA ligase 4target
IcosapentSodium/calcium exchanger 1target
IcosapentPeroxisome proliferator-activated receptor gammatarget
IcosapentPeroxisome proliferator-activated receptor deltatarget
IcosapentTransient receptor potential cation channel subfamily V member 1target
IcosapentPeroxisome proliferator-activated receptor alphatarget
IcosapentSerum albumincarrier
TreprostinilP2Y purinoceptor 12target
TreprostinilPeroxisome proliferator-activated receptor deltatarget
TreprostinilProstacyclin receptortarget
TreprostinilCytochrome P450 2C9enzyme
Carboprost tromethamineProstaglandin E2 receptor EP1 subtypetarget
AlprostadilProstaglandin E2 receptor EP2 subtypetarget
AlprostadilProstaglandin E2 receptor EP1 subtypetarget
AlprostadilMultidrug resistance-associated protein 5transporter
AlprostadilSolute carrier organic anion transporter family member 2B1transporter
AlprostadilSolute carrier organic anion transporter family member 3A1transporter
AlprostadilMultidrug resistance-associated protein 4transporter
AlprostadilSolute carrier organic anion transporter family member 2A1transporter
AlprostadilProstaglandin D2 receptor 2target
AlprostadilSolute carrier family 22 member 6transporter
BimatoprostProstaglandin F2-alpha receptortarget
BimatoprostProstaglandin E2 receptor EP1 subtypetarget
BimatoprostProstaglandin E2 receptor EP3 subtypetarget
BimatoprostCytochrome P450 3A4enzyme
BimatoprostCytochrome P450 3A5enzyme
DinoprostoneProstaglandin E2 receptor EP2 subtypetarget
DinoprostoneProstaglandin E2 receptor EP1 subtypetarget
DinoprostoneProstaglandin E2 receptor EP4 subtypetarget
DinoprostoneProstaglandin E2 receptor EP3 subtypetarget
DinoprostoneSolute carrier family 22 member 2transporter
DinoprostoneMultidrug resistance-associated protein 5transporter
DinoprostoneSolute carrier family 22 member 6transporter
DinoprostoneSolute carrier family 22 member 8transporter
DinoprostoneSolute carrier family 22 member 11transporter
DinoprostoneSolute carrier family 22 member 7transporter
DinoprostoneMultidrug resistance-associated protein 4transporter
DinoprostoneSolute carrier organic anion transporter family member 2B1transporter
DinoprostoneSolute carrier organic anion transporter family member 1A2transporter
DinoprostoneOrganic solute transporter subunit alphatransporter
DinoprostoneOrganic solute transporter subunit betatransporter
DinoprostoneSolute carrier organic anion transporter family member 2A1transporter
DinoprostoneSolute carrier organic anion transporter family member 4A1transporter
DinoprostoneSolute carrier organic anion transporter family member 1C1transporter
DinoprostoneSolute carrier organic anion transporter family member 3A1transporter
DinoprostoneSolute carrier organic anion transporter family member 1B1transporter
DinoprostoneProstaglandin D2 receptor 2target
MisoprostolProstaglandin E2 receptor EP2 subtypetarget
MisoprostolProstaglandin E2 receptor EP3 subtypetarget
MisoprostolProstaglandin E2 receptor EP4 subtypetarget
MisoprostolProstaglandin E2 receptor EP1 subtypetarget
LubiprostoneChloride channel protein 2target
LubiprostoneCarbonyl reductase [NADPH] 1enzyme
IloprostProstacyclin receptortarget
IloprostTissue-type plasminogen activatortarget
IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
IloprostSolute carrier organic anion transporter family member 2B1transporter
IloprostSolute carrier organic anion transporter family member 2A1transporter
IloprostSolute carrier organic anion transporter family member 3A1transporter
IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Ctarget
IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
IloprostProstaglandin E2 receptor EP1 subtypetarget
IloprostProstaglandin D2 receptor 2target
Dinoprost tromethamineProstacyclin receptortarget
Dinoprost tromethamineProstaglandin F2-alpha receptortarget
Dinoprost tromethamineSolute carrier family 22 member 2transporter
Dinoprost tromethamineSolute carrier family 22 member 6transporter
Dinoprost tromethamineSolute carrier family 22 member 7transporter
Dinoprost tromethamineSolute carrier family 22 member 8transporter
Dinoprost tromethamineSolute carrier family 22 member 11transporter
Dinoprost tromethamineSolute carrier organic anion transporter family member 2A1transporter
Dinoprost tromethamineSolute carrier organic anion transporter family member 3A1transporter
EpoprostenolP2Y purinoceptor 12target
EpoprostenolProstacyclin receptortarget
EpoprostenolProstacyclin synthasetarget
BufotenineAmine oxidase [flavin-containing] Aenzyme
Platelet Activating FactorGanglioside GM2 activatortarget
Platelet Activating FactorP-glycoprotein 1transporter
Platelet Activating FactorPlatelet-activating factor receptortarget
Prostaglandin G2Prostaglandin G/H synthase 2target
Arachidonic AcidProstaglandin G/H synthase 1target
Arachidonic AcidSerum albumincarrier
Arachidonic AcidFatty acid-binding protein, adipocytecarrier
Arachidonic Acid14 kDa fatty acid-binding proteintarget
Arachidonic AcidFatty acid-binding protein, intestinalcarrier
Arachidonic AcidCytochrome P450 2C9enzyme
Arachidonic AcidSolute carrier organic anion transporter family member 2A1transporter
Arachidonic AcidPeroxisome proliferator-activated receptor alphatarget
Arachidonic AcidBile acid receptortarget
Arachidonic AcidRetinoic acid receptor RXR-alphatarget
N-acetylhistamineGlutaminyl-peptide cyclotransferasetarget
BeraprostProstacyclin receptortarget
BeraprostCytochrome P450 2C8enzyme
HistamineHistamine H1 receptortarget
HistamineHistamine H2 receptortarget
HistamineHistamine H3 receptortarget
HistamineHistamine N-methyltransferaseenzyme
HistamineSolute carrier family 22 member 2transporter
HistamineSolute carrier family 22 member 1transporter
HistamineSolute carrier family 22 member 3transporter
HistamineSolute carrier family 22 member 5transporter
HistamineHistamine H4 receptortarget
HistamineSynaptic vesicular amine transportertarget
CobiprostoneChloride channel protein 2target
CTCE-0214Stromal cell-derived factor 1target
IcatibantB2 bradykinin receptortarget
IcatibantAminopeptidase Ntarget
LabradimilB2 bradykinin receptortarget
TafluprostProstaglandin F2-alpha receptortarget
TafluprostProstaglandin G/H synthase 2enzyme
SerotoninSolute carrier family 22 member 2transporter
SerotoninSodium-dependent serotonin transportertarget
Serotonin5-hydroxytryptamine receptor 2Atarget
Serotonin5-hydroxytryptamine receptor 3Atarget
Serotonin5-hydroxytryptamine receptor 3Btarget
SerotoninSynaptic vesicular amine transportertarget
Leukotriene C4Solute carrier organic anion transporter family member 1B1transporter
Leukotriene C4Solute carrier organic anion transporter family member 1B3transporter
Leukotriene C4Cysteinyl leukotriene receptor 1target
Leukotriene C4Cysteinyl leukotriene receptor 2target
Leukotriene C4Multidrug resistance-associated protein 1target
GemeprostProstaglandin E2 receptor EP2 subtypetarget
GemeprostProstaglandin E2 receptor EP3 subtypetarget
LimaprostProstaglandin E2 receptor EP1 subtypetarget
LimaprostProstaglandin E2 receptor EP2 subtypetarget
LimaprostProstaglandin E2 receptor EP3 subtypetarget
LimaprostProstaglandin E2 receptor EP4 subtypetarget
Omega-3-acid ethyl estersSterol O-acyltransferase 1enzyme
Omega-3-acid ethyl estersSterol regulatory element-binding protein 1target
Latanoprostene bunodProstaglandin F2-alpha receptortarget
Latanoprostene bunodSolute carrier organic anion transporter family member 2B1transporter
Angiotensin IIType-1 angiotensin II receptortarget
Leukotriene D4Cysteinyl leukotriene receptor 1target
Leukotriene D4Cysteinyl leukotriene receptor 2target
DinoprostProstaglandin D2 receptor 2target
Leukotriene B4Leukotriene B4 receptor 1target
Leukotriene B4Leukotriene B4 receptor 2target
Leukotriene B4Peroxisome proliferator-activated receptor alphatarget
Prostaglandin D2Aldo-keto reductase family 1 member C3target
Prostaglandin D2Solute carrier organic anion transporter family member 2A1transporter
Prostaglandin D2Prostaglandin D2 receptor 2target
N-acetylserotoninSepiapterin reductasetarget
TravoprostProstaglandin F2-alpha receptortarget
Methoxy arachidonyl fluorophosphonateFatty-acid amide hydrolase 1target
Sar9, Met (O2)11-Substance PCytochrome P450 19A1enzyme
Sar9, Met (O2)11-Substance PCholinesteraseenzyme
Sar9, Met (O2)11-Substance PProstaglandin G/H synthase 2enzyme