Inflammation Mediators

The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).
DrugDrug NameDrug Indication
DB00154Dihomo-gamma-linolenic acidFor nutritional supplementation, also for treating dietary shortage or imbalance
DB00158Folic acidFolic acid is indicated for the treatment of folic acid deficiency, megaloblastic anemia, and in anemias of nutritional origins, pregnancy, infancy, or childhood.
DB00159IcosapentEPA can be used for lowering elevated triglycerides in those who are hyperglyceridemic. In addition, EPA may play a therapeutic role in patients with cystic fibrosis by reducing disease severity and may play a similar role in type 2 diabetics in slowing the progression of diabetic nephropathy.
DB00374TreprostinilFor use as a continuous subcutaneous infusion or intravenous infusion (for those not able to tolerate a subcutaneous infusion) for the treatment of pulmonary arterial hypertension in patients with NYHA Class II-IV symptoms to diminish symptoms associated with exercise.
DB00429Carboprost tromethamineFor aborting pregnancy between the 13th and 20th weeks of gestation as calculated from the first day of the last normal menstrual period and in the following conditions related to second trimester abortion: 1. Failure of expulsion of the fetus during the course of treatment by another method; 2. Premature rupture of membranes in intrauterine methods with loss of drug and insufficient or absent uterine activity; 3. Requirement of a repeat intrauterine instillation of drug for expulsion of the fetus; 4. Inadvertent or spontaneous rupture of membranes in the presence of a previable fetus and absence of adequate activity for expulsion. Also for the treatment of postpartum hemorrhage due to uterine atony which has not responded to conventional methods of management.
DB00654LatanoprostFor the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
DB00770AlprostadilFor palliative, not definitive, therapy to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in neonates who have congenital heart defects and who depend upon the patent ductus for survival. Also for the treatment of erectile dysfunction due to neurogenic, vasculogenic, psychogenic, or mixed etiology.
DB00905BimatoprostBimatoprost is used for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. These patients must be intolerant to other intraocular pressure lowering medications or inadequately responsive to other treatments.[L6877] Bimatoprost is also indicated to treat eyelash hypotrichosis.[L6910]
DB00917DinoprostoneFor the termination of pregnancy during the second trimester (from the 12th through the 20th gestational week as calculated from the first day of the last normal menstrual period), as well as for evacuation of the uterine contents in the management of missed abortion or intrauterine fetal death up to 28 weeks of gestational age as calculated from the first day of the last normal menstrual period. Also used in the management of nonmetastatic gestational trophoblastic disease (benign hydatidiform mole). Other indications include improving the cervical inducibility (cervical "ripening") in pregnant women at or near term with a medical or obstetrical need for labor induction, and the management of postpartum hemorrhage.
DB00929MisoprostolIndicated for the treatment of ulceration (duodenal, gastric and NSAID induced) and prophylaxis for NSAID induced ulceration. Misoprostol is also indicated for other uses that are not approved in Canada, including the medical termination of an intrauterine pregnancy used alone or in combination with methotrexate,as well as the induction of labour in a selected population of pregnant women with unfavourable cervices. This indication is avoided in women with prior uterine surgery or cesarean surgery due to an increased risk of possible uterine rupture. Misoprostol is also used for the prevention or treatment of serious postpartum hemorrhage.
DB01046LubiprostoneFor the treatment of chronic idiopathic constipation in the adult population. Also used for the treatment of irritable bowel syndrome with constipation in women who are 18 years of age or older.
DB01088IloprostUsed for the treatment of pulmonary arterial hypertension.
DB01160Dinoprost tromethamineUsed for aborting second-trimester pregnancy (between the twelfth to eighteenth week of gestation) and in incomplete abortion or for therapeutic abortion in cases of intrauterine fetal death and congenital abnormalities incompatible with life. Also used at low-doses for medically indicated induction of labor at term. Also injected intra-arterially for use as a vasodilator to assist in angiography.
DB01240EpoprostenolFor the long-term intravenous treatment of primary pulmonary hypertension and pulmonary hypertension associated with the scleroderma spectrum of disease in NYHA Class III and Class IV patients who do not respond adequately to conventional therapy.
DB014415-Methoxy-N,N-diisopropyltryptamineNot Available
DB01445BufotenineNot Available
DB02261Platelet Activating FactorNot Available
DB02304Prostaglandin B2Not Available
DB03866Prostaglandin G2Not Available
DB04557Arachidonic AcidNot Available
DB04622N-ACETYLHISTAMINENot Available
DB05229BeraprostFor the treatment of pulmonary hypertension.
DB05381HistamineHistamine phosphate is indicated as a diagnostic aid for evaluation of gastric acid secretory function.
DB05514CobiprostoneInvestigated for use/treatment in cystic fibrosis.
DB05934CTCE-0214Investigated for use/treatment in adverse effects (chemotherapy), blood (blood forming organ disorders, unspecified), cancer/tumors (unspecified), neutropenics, and vascular diseases.
DB06196IcatibantApproved for use in acute attacks of hereditary angioedema (HAE). Investigated for use/treatment in angioedema, liver disease, and burns and burn infections.
DB06549LabradimilInvestigated for use/treatment in brain cancer and pediatric indications.
DB06633N-chlorotaurineInvestigated for use/treatment in eye disorders/infections.
DB06763SaralasinNot Available
DB06826UnoprostoneFor the lowering of intraocular pressure in patients with open-angle glaucoma or ocular hypertension who are intolerant of other intraocular pressure lowering medications or insufficiently responsive (failed to achieve target IOP determined after multiple measurements over time) to another intraocular pressure lowering medication.
DB08819TafluprostTafluprost is indicated for reducing elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
DB08839SerotoninNot Available
DB08855Leukotriene C4Not Available
DB08887Icosapent ethylIcosapent ethyl is used as adjunct therapy to reduce triglyceride (TG) levels in adults with severe (>500 mg/dL) hypertriglyceridemia.
DB08964GemeprostIndicated for the softening and dilatation of the cervix uteri prior to transcervical, intrauterine operative procedures in the first trimester of pregnancy or facilitating therapeutic termination of pregnancy in patients in the second trimester of gestation.
DB09211LimaprostLimaprost is used for the improvement of various ischemic symptoms such as ulcer, pain and feeling of coldness associated with thromboangiitis obliterans as well as improvement of subjective symptoms (pain and numbness of lower legs) and gait ability associated with acquired lumbar spinal canal stenosis (in patients with bilateral intermittent claudication showing normal SLR test result).
DB09539Omega-3-acid ethyl estersOmega-3-Acid Ethyl Esters capsules, USP are indicated as an adjunct to diet to reduce triglyceride (TG) levels in adult patients with severe (≥500 mg/dL) hypertriglyceridemia (HTG)[FDA Label][A176687].
DB11411FenprostaleneNot Available
DB11425LuprostiolNot Available
DB11454ProstaleneNot Available
DB11507CloprostenolNot Available
DB11519FluprostenolNot Available
DB11660Latanoprostene BunodLatanoprostene bunod opthalmic solution is indicated for the reduction of intraocular pressure in patients with open-angle glaucoma or ocular hypertension [FDA Label].
DB11842Angiotensin IIAngiotensin II is a vasoconstrictor indicated for increasing blood pressure in adults with septic or other distributive shock [FDA Label].
DB11858Leukotriene D4Not Available
DB12075NagrestipenNot Available
DB12126BradykininNot Available
DB12708SulprostoneNot Available
DB12789DinoprostNot Available
DB12961Leukotriene B4Not Available
DB13105Resolvin E1Not Available
DB13517AngiotensinamideNot Available
DB13824EnprostilNot Available
DB140105-methoxy-N,N-dimethyltryptamineNot Available
DB02056Prostaglandin D2Not Available
DB04275N-acetylserotoninNot Available
DB00287TravoprostTravoprost ophthalmic solution is indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension [F3061, F3064, L5146]. Travoprost is also currently indicated for the decrease of elevated intraocular pressure in paediatric patients aged 2 months to < 18 years with ocular hypertension or paediatric glaucoma [L5146].
DB02465Methoxy arachidonyl fluorophosphonateNot Available
DB05875Sar9, Met (O2)11-Substance PInvestigated for use/treatment in acute respiratory distress syndrome (ARDS) and viral infection.
DrugDrug NameTargetType
DB00154Dihomo-gamma-linolenic acidProstaglandin G/H synthase 2target
DB00154Dihomo-gamma-linolenic acidProstaglandin G/H synthase 1target
DB00154Dihomo-gamma-linolenic acidFatty acid-binding protein, braincarrier
DB00158Folic acidFolate receptor gammatarget
DB00158Folic acidFolate receptor betatarget
DB00158Folic acidMethylenetetrahydrofolate reductaseenzyme
DB00158Folic acidMultidrug resistance-associated protein 4transporter
DB00158Folic acidSolute carrier family 22 member 6transporter
DB00158Folic acidCanalicular multispecific organic anion transporter 2transporter
DB00158Folic acidATP-binding cassette sub-family C member 11transporter
DB00158Folic acidATP-binding cassette sub-family G member 2transporter
DB00158Folic acidProton-coupled folate transportertransporter
DB00158Folic acidMitochondrial folate transporter/carriertransporter
DB00158Folic acidGamma-glutamyl hydrolaseenzyme
DB00158Folic acidFolate receptor alphatarget
DB00158Folic acidDihydrofolate reductaseenzyme
DB00159IcosapentProstaglandin G/H synthase 2target
DB00159IcosapentProstaglandin G/H synthase 1target
DB00159IcosapentFree fatty acid receptor 1target
DB00159IcosapentFatty acid-binding protein, braincarrier
DB00159IcosapentFatty acid desaturase 1target
DB00159IcosapentLong-chain-fatty-acid--CoA ligase 4target
DB00159IcosapentLong-chain-fatty-acid--CoA ligase 3target
DB00159IcosapentSodium/calcium exchanger 1target
DB00159IcosapentPeroxisome proliferator-activated receptor gammatarget
DB00159IcosapentPeroxisome proliferator-activated receptor deltatarget
DB00159IcosapentTransient receptor potential cation channel subfamily V member 1target
DB00159IcosapentPeroxisome proliferator-activated receptor alphatarget
DB00159IcosapentSerum albumincarrier
DB00374TreprostinilP2Y purinoceptor 12target
DB00374TreprostinilPeroxisome proliferator-activated receptor deltatarget
DB00374TreprostinilProstacyclin receptortarget
DB00374TreprostinilCytochrome P450 2C9enzyme
DB00429Carboprost tromethamineProstaglandin E2 receptor EP1 subtypetarget
DB00654LatanoprostProstaglandin F2-alpha receptortarget
DB00654LatanoprostSolute carrier organic anion transporter family member 2B1transporter
DB00654LatanoprostSolute carrier family 22 member 1transporter
DB00770AlprostadilProstaglandin E2 receptor EP2 subtypetarget
DB00770AlprostadilProstaglandin E2 receptor EP1 subtypetarget
DB00770AlprostadilMultidrug resistance-associated protein 5transporter
DB00770AlprostadilSolute carrier organic anion transporter family member 2B1transporter
DB00770AlprostadilSolute carrier organic anion transporter family member 3A1transporter
DB00770AlprostadilMultidrug resistance-associated protein 4transporter
DB00770AlprostadilSolute carrier organic anion transporter family member 2A1transporter
DB00770AlprostadilProstaglandin D2 receptor 2target
DB00770AlprostadilSolute carrier family 22 member 6transporter
DB00905BimatoprostProstaglandin F2-alpha receptortarget
DB00905BimatoprostProstaglandin E2 receptor EP1 subtypetarget
DB00905BimatoprostProstaglandin E2 receptor EP3 subtypetarget
DB00905BimatoprostCytochrome P450 3A4enzyme
DB00905BimatoprostCytochrome P450 3A5enzyme
DB00917DinoprostoneProstaglandin E2 receptor EP2 subtypetarget
DB00917DinoprostoneProstaglandin E2 receptor EP1 subtypetarget
DB00917DinoprostoneProstaglandin E2 receptor EP4 subtypetarget
DB00917DinoprostoneProstaglandin E2 receptor EP3 subtypetarget
DB00917DinoprostoneSolute carrier family 22 member 2transporter
DB00917DinoprostoneMultidrug resistance-associated protein 5transporter
DB00917DinoprostoneSolute carrier family 22 member 6transporter
DB00917DinoprostoneSolute carrier family 22 member 8transporter
DB00917DinoprostoneSolute carrier family 22 member 11transporter
DB00917DinoprostoneSolute carrier family 22 member 7transporter
DB00917DinoprostoneMultidrug resistance-associated protein 4transporter
DB00917DinoprostoneSolute carrier organic anion transporter family member 2B1transporter
DB00917DinoprostoneSolute carrier organic anion transporter family member 1A2transporter
DB00917DinoprostoneOrganic solute transporter subunit alphatransporter
DB00917DinoprostoneOrganic solute transporter subunit betatransporter
DB00917DinoprostoneSolute carrier organic anion transporter family member 2A1transporter
DB00917DinoprostoneSolute carrier organic anion transporter family member 4A1transporter
DB00917DinoprostoneSolute carrier organic anion transporter family member 1C1transporter
DB00917DinoprostoneSolute carrier organic anion transporter family member 3A1transporter
DB00917DinoprostoneSolute carrier organic anion transporter family member 1B1transporter
DB00917DinoprostoneCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DB00917DinoprostoneCytochrome P450 19A1enzyme
DB00917DinoprostoneProstaglandin D2 receptor 2target
DB00929MisoprostolProstaglandin E2 receptor EP2 subtypetarget
DB00929MisoprostolProstaglandin E2 receptor EP3 subtypetarget
DB00929MisoprostolProstaglandin E2 receptor EP4 subtypetarget
DB01046LubiprostoneChloride channel protein 2target
DB01046LubiprostoneCarbonyl reductase [NADPH] 1enzyme
DB01088IloprostProstacyclin receptortarget
DB01088IloprostTissue-type plasminogen activatortarget
DB01088IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DB01088IloprostSolute carrier organic anion transporter family member 2B1transporter
DB01088IloprostSolute carrier organic anion transporter family member 2A1transporter
DB01088IloprostSolute carrier organic anion transporter family member 3A1transporter
DB01088IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB01088IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Ctarget
DB01088IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
DB01088IloprostProstaglandin E2 receptor EP1 subtypetarget
DB01088IloprostProstaglandin D2 receptor 2target
DB01160Dinoprost tromethamineProstacyclin receptortarget
DB01160Dinoprost tromethamineProstaglandin F2-alpha receptortarget
DB01160Dinoprost tromethamineSolute carrier family 22 member 2transporter
DB01160Dinoprost tromethamineSolute carrier family 22 member 6transporter
DB01160Dinoprost tromethamineSolute carrier family 22 member 7transporter
DB01160Dinoprost tromethamineSolute carrier family 22 member 8transporter
DB01160Dinoprost tromethamineSolute carrier family 22 member 11transporter
DB01160Dinoprost tromethamineSolute carrier organic anion transporter family member 2A1transporter
DB01160Dinoprost tromethamineSolute carrier organic anion transporter family member 3A1transporter
DB01240EpoprostenolP2Y purinoceptor 12target
DB01240EpoprostenolProstacyclin receptortarget
DB01240EpoprostenolProstacyclin synthasetarget
DB01445BufotenineAmine oxidase [flavin-containing] Aenzyme
DB01445BufotenineAmine oxidase [flavin-containing] Benzyme
DB02261Platelet Activating FactorGanglioside GM2 activatortarget
DB02261Platelet Activating FactorMultidrug resistance protein 1transporter
DB02261Platelet Activating FactorPlatelet-activating factor receptortarget
DB03866Prostaglandin G2Prostaglandin G/H synthase 2target
DB04557Arachidonic AcidProstaglandin G/H synthase 1target
DB04557Arachidonic AcidSerum albumincarrier
DB04557Arachidonic AcidFatty acid-binding protein, adipocytecarrier
DB04557Arachidonic Acid14 kDa fatty acid-binding proteintarget
DB04557Arachidonic AcidFatty acid-binding protein, intestinalcarrier
DB04557Arachidonic AcidCytochrome P450 2C9enzyme
DB04557Arachidonic AcidSolute carrier organic anion transporter family member 2A1transporter
DB04557Arachidonic AcidPeroxisome proliferator-activated receptor alphatarget
DB04557Arachidonic AcidBile acid receptortarget
DB04557Arachidonic AcidRetinoic acid receptor RXR-alphatarget
DB04622N-ACETYLHISTAMINEGlutaminyl-peptide cyclotransferasetarget
DB05229BeraprostProstacyclin receptortarget
DB05229BeraprostCytochrome P450 2C8enzyme
DB05381HistamineHistamine H1 receptortarget
DB05381HistamineHistamine H2 receptortarget
DB05381HistamineHistamine H3 receptortarget
DB05381HistamineHistamine N-methyltransferaseenzyme
DB05381HistamineSolute carrier family 22 member 2transporter
DB05381HistamineSolute carrier family 22 member 1transporter
DB05381HistamineSolute carrier family 22 member 3transporter
DB05381HistamineSolute carrier family 22 member 5transporter
DB05381HistamineHistamine H4 receptortarget
DB05381HistamineCytochrome P450 2C9enzyme
DB05381HistamineCytochrome P450 3A4enzyme
DB05381HistamineSynaptic vesicular amine transportertarget
DB05514CobiprostoneChloride channel protein 2target
DB05934CTCE-0214Stromal cell-derived factor 1target
DB06196IcatibantB2 bradykinin receptortarget
DB06196IcatibantAminopeptidase Ntarget
DB06549LabradimilB2 bradykinin receptortarget
DB08819TafluprostProstaglandin F2-alpha receptortarget
DB08819TafluprostProstaglandin G/H synthase 2enzyme
DB08839SerotoninSolute carrier family 22 member 2transporter
DB08839SerotoninSodium-dependent serotonin transportertarget
DB08839Serotonin5-hydroxytryptamine receptor 2Atarget
DB08839Serotonin5-hydroxytryptamine receptor 3Atarget
DB08839Serotonin5-hydroxytryptamine receptor 3Btarget
DB08839SerotoninSynaptic vesicular amine transportertarget
DB08855Leukotriene C4Solute carrier organic anion transporter family member 1B1transporter
DB08855Leukotriene C4Solute carrier organic anion transporter family member 1B3transporter
DB08855Leukotriene C4Cysteinyl leukotriene receptor 1target
DB08855Leukotriene C4Cysteinyl leukotriene receptor 2target
DB08855Leukotriene C4Multidrug resistance-associated protein 1target
DB08964GemeprostProstaglandin E2 receptor EP2 subtypetarget
DB08964GemeprostProstaglandin E2 receptor EP3 subtypetarget
DB09211LimaprostProstaglandin E2 receptor EP1 subtypetarget
DB09211LimaprostProstaglandin E2 receptor EP2 subtypetarget
DB09211LimaprostProstaglandin E2 receptor EP3 subtypetarget
DB09211LimaprostProstaglandin E2 receptor EP4 subtypetarget
DB09539Omega-3-acid ethyl estersSterol O-acyltransferase 1enzyme
DB09539Omega-3-acid ethyl estersSterol regulatory element-binding protein 1target
DB11660Latanoprostene BunodProstaglandin F2-alpha receptortarget
DB11660Latanoprostene BunodSolute carrier organic anion transporter family member 2B1transporter
DB11842Angiotensin IIType-1 angiotensin II receptortarget
DB11858Leukotriene D4Cysteinyl leukotriene receptor 1target
DB11858Leukotriene D4Cysteinyl leukotriene receptor 2target
DB12789DinoprostProstaglandin D2 receptor 2target
DB12961Leukotriene B4Leukotriene B4 receptor 1target
DB12961Leukotriene B4Leukotriene B4 receptor 2target
DB12961Leukotriene B4Peroxisome proliferator-activated receptor alphatarget
DB140105-methoxy-N,N-dimethyltryptamine5-hydroxytryptamine receptor 1Atarget
DB140105-methoxy-N,N-dimethyltryptamine5-hydroxytryptamine receptor 2Atarget
DB140105-methoxy-N,N-dimethyltryptamineCytochrome P450 2D6enzyme
DB02056Prostaglandin D2Aldo-keto reductase family 1 member C3target
DB02056Prostaglandin D2Solute carrier organic anion transporter family member 2A1transporter
DB02056Prostaglandin D2Prostaglandin D2 receptor 2target
DB04275N-acetylserotoninSepiapterin reductasetarget
DB00287TravoprostProstaglandin F2-alpha receptortarget
DB02465Methoxy arachidonyl fluorophosphonateFatty-acid amide hydrolase 1target
DB05875Sar9, Met (O2)11-Substance PCytochrome P450 19A1enzyme
DB05875Sar9, Met (O2)11-Substance PCholinesteraseenzyme
DB05875Sar9, Met (O2)11-Substance PProstaglandin G/H synthase 2enzyme