Inflammation Mediators

The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).
DrugDrug NameDrug Description
DB00154Dihomo-gamma-linolenic acidFor nutritional supplementation, also for treating dietary shortage or imbalance
DB00159IcosapentA polyunsaturated fatty acid, usually found in fish oils, that is used in many supplements.
DB00374TreprostinilA prostacyclin vasodilator for the treatment of pulmonary arterial hypertension to relieve exercise associated symptoms and to prevent clinical deterioration after stopping epoprostenol.
DB00429Carboprost tromethamineA prostaglandin used to treat postpartum uterine hemorrhage due to atony when other methods of management have not been effective.
DB00770AlprostadilA medication used to treat erectile dysfunction.
DB00905BimatoprostA prostaglandin analog used to treat hypotrichosis of the eyelashes and intraocular pressure in open angle glaucoma or ocular hypertension.
DB00917DinoprostoneA prostaglandin used to induce labor or abortion as well as to treat nonmetastatic gestational trophoblastic disease.
DB00929MisoprostolA prostaglandin E1 analogue used to reduce the risk of NSAID-induced gastric ulcers.
DB01046LubiprostoneA prostaglandin derivative used to treat constipation caused by irritable bowel syndrome and opioid-use.
DB01088IloprostA synthetic prostacyclin analog indicated to treat pulmonary arterial hypertension (PAH).
DB01160Dinoprost tromethamineUsed for aborting second-trimester pregnancy (between the twelfth to eighteenth week of gestation) and in incomplete abortion or for therapeutic abortion in cases of intrauterine fetal death and congenital abnormalities...
DB01240EpoprostenolA vasodilator and platelet aggregation inhibitor used for the management of primary pulmonary hypertension and pulmonary hypertension in patients with heart failure.
DB014415-Methoxy-N,N-diisopropyltryptamine5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) is a tryptamine derivative and shares many similarities with schedule I tryptamine hallucinogens such as alpha-ethyltryptamine, N,N-dimethyltryptamine, N,N-diethyltryptamine, bufotenine, psilocybin and psilocin. Since 1999, there has been a...
DB01445BufotenineA hallucinogenic serotonin analog found in frog or toad skins, mushrooms, higher plants, and mammals, especially in the brains, plasma, and urine of schizophrenics. Bufotenin has been used as a...
DB02261Platelet Activating FactorNot Available
DB02304Prostaglandin B2Not Available
DB03866Prostaglandin G2A cyclic endoperoxide intermediate produced by the action of CYCLOOXYGENASE on ARACHIDONIC ACID. It is further converted by a series of specific enzymes to the series 2 prostaglandins. [PubChem]
DB04557Arachidonic AcidAn unsaturated, essential fatty acid. It is found in animal and human fat as well as in the liver, brain, and glandular organs, and is a constituent of animal phosphatides....
DB04622N-ACETYLHISTAMINENot Available
DB05229BeraprostFor the treatment of pulmonary hypertension.
DB05381HistamineAn ingredient of topical drugs for the relief of joint pain or muscle aches and pains.
DB05514CobiprostoneInvestigated for use/treatment in cystic fibrosis.
DB05934CTCE-0214Investigated for use/treatment in adverse effects (chemotherapy), blood (blood forming organ disorders, unspecified), cancer/tumors (unspecified), neutropenics, and vascular diseases.
DB06196IcatibantA bradykinin B2 receptor antagonist used to treat acute episodes of swelling and inflammation associated with hereditary angioedema (HAE).
DB06549LabradimilInvestigated for use/treatment in brain cancer and pediatric indications.
DB06633N-chlorotaurineInvestigated for use/treatment in eye disorders/infections.
DB06763SaralasinNot Annotated
DB06826UnoprostoneA prostaglandin analogue used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension who are clinically unresponsive to other ocular antihypertensive agents.
DB08819TafluprostAn ophthalmic prostaglandin analog used to lower intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
DB08839SerotoninFor temporary relief of nervousness, anxiety, mood swings, joint pains, weakness, drowsiness, itching and lethargy. Not evaluated by the FDA, homeopathic product.
DB08855Leukotriene C4The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates...
DB08887Icosapent ethylAn ethyl ester of eicosapentaenoic acid (EPA) that reduces synthesis and enhances clearance of triglycerides that is used to treat patients with severe hypertriglyceridemia.
DB08964GemeprostIndicated for the softening and dilatation of the cervix uteri prior to transcervical, intrauterine operative procedures in the first trimester of pregnancy or facilitating therapeutic termination of pregnancy in patients...
DB09211LimaprostLimaprost is used for the improvement of various ischemic symptoms such as ulcer, pain and feeling of coldness associated with thromboangiitis obliterans as well as improvement of subjective symptoms (pain...
DB09539Omega-3-acid ethyl estersA mixture of fatty acids used as an adjunct to diet to reduce triglyceride (TG) levels in adult patients with severe hypertriglyceridemia.
DB11411FenprostaleneNot Annotated
DB11425LuprostiolNot Annotated
DB11454ProstaleneAnalog of prostaglandin F2 alpha.
DB11507CloprostenolNot Annotated
DB11519FluprostenolNot Annotated
DB11660Latanoprostene bunodA prostaglandin analog used to reduce ocular hypertension or treat open-angle glaucoma.
DB11842Angiotensin IIA peptide hormone of the RAAS system used to raise blood pressure in septic or other forms of shock.
DB11858Leukotriene D4Leukotriene D4 has been used in trials studying the diagnostic of Asthma and Allergic Rhinitis.
DB12075NagrestipenNagrestipen has been used in trials studying the treatment of CANCER, Neoplasm, Metastasis, Radiation Oncology, and Neoplasm Metastasis.
DB12126BradykininBradykinin has been investigated for the basic science and treatment of Hypertension and Diabetes Type 2.
DB12708SulprostoneSulprostone has been used in trials studying Abortion, Induced.
DB12789DinoprostA medication used to induce a second trimester abortion.
DB12961Leukotriene B4Leukotriene B4 has been used in trials studying the treatment of HIV Infections.
DB13105Resolvin E1Resolvin E1 (RX 10001) is under investigation in clinical trial NCT00941018 (Single and Multiple Ascending Oral Dose Study of Resolvin E1 in Healthy Volunteers).
DB13517AngiotensinamideNot Annotated
DB13824EnprostilNot Annotated
DB02056Prostaglandin D2The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesized by alveolar macrophages. Among its many biological actions, the most important...
DB04275N-acetylserotoninNot Available
DB00287TravoprostA prostaglandin analog used in the treatment of elevated intraocular pressure due to open angle glaucoma or ocular hypertension.
DB02465Methoxy arachidonyl fluorophosphonateMethoxy arachidonyl fluorophosphonate, commonly referred as MAFP, is an irreversible active site-directed enzyme inhibitor that inhibits nearly all serine hydrolases and serine proteases. It inhibits phospholipase A2 and fatty acid...
DB05875Sar9, Met (O2)11-Substance PInvestigated for use/treatment in acute respiratory distress syndrome (ARDS) and viral infection.
DB11720Angiotensin 1-7TXA127 has been investigated for the treatment of Miscellaneous Peripheral Blood Cell Abnormalities.
DB12631AclerastideAclerastide has been investigated for the treatment of Diabetic Foot, Diabetic Foot Ulcers, and Foot Ulcer, Diabetic.
DB15010EdasalonexentEdasalonexent is under investigation in clinical trial NCT01511900 (A Multiple Ascending Dose Study of CAT-1004 in Patients With Type 2 Diabetes).
DrugDrug NameTargetType
DB00154Dihomo-gamma-linolenic acidProstaglandin G/H synthase 2target
DB00154Dihomo-gamma-linolenic acidProstaglandin G/H synthase 1target
DB00154Dihomo-gamma-linolenic acidFatty acid-binding protein, braincarrier
DB00159IcosapentProstaglandin G/H synthase 2target
DB00159IcosapentProstaglandin G/H synthase 1target
DB00159IcosapentFree fatty acid receptor 1target
DB00159IcosapentFatty acid-binding protein, braincarrier
DB00159IcosapentFatty acid desaturase 1target
DB00159IcosapentLong-chain-fatty-acid--CoA ligase 4target
DB00159IcosapentLong-chain-fatty-acid--CoA ligase 3target
DB00159IcosapentSodium/calcium exchanger 1target
DB00159IcosapentPeroxisome proliferator-activated receptor gammatarget
DB00159IcosapentPeroxisome proliferator-activated receptor deltatarget
DB00159IcosapentTransient receptor potential cation channel subfamily V member 1target
DB00159IcosapentPeroxisome proliferator-activated receptor alphatarget
DB00159IcosapentSerum albumincarrier
DB00374TreprostinilP2Y purinoceptor 12target
DB00374TreprostinilPeroxisome proliferator-activated receptor deltatarget
DB00374TreprostinilProstacyclin receptortarget
DB00374TreprostinilCytochrome P450 2C9enzyme
DB00429Carboprost tromethamineProstaglandin E2 receptor EP1 subtypetarget
DB00770AlprostadilProstaglandin E2 receptor EP2 subtypetarget
DB00770AlprostadilProstaglandin E2 receptor EP1 subtypetarget
DB00770AlprostadilMultidrug resistance-associated protein 5transporter
DB00770AlprostadilSolute carrier organic anion transporter family member 2B1transporter
DB00770AlprostadilSolute carrier organic anion transporter family member 3A1transporter
DB00770AlprostadilMultidrug resistance-associated protein 4transporter
DB00770AlprostadilSolute carrier organic anion transporter family member 2A1transporter
DB00770AlprostadilProstaglandin D2 receptor 2target
DB00770AlprostadilSolute carrier family 22 member 6transporter
DB00905BimatoprostProstaglandin F2-alpha receptortarget
DB00905BimatoprostProstaglandin E2 receptor EP1 subtypetarget
DB00905BimatoprostProstaglandin E2 receptor EP3 subtypetarget
DB00905BimatoprostCytochrome P450 3A4enzyme
DB00905BimatoprostCytochrome P450 3A5enzyme
DB00917DinoprostoneProstaglandin E2 receptor EP2 subtypetarget
DB00917DinoprostoneProstaglandin E2 receptor EP1 subtypetarget
DB00917DinoprostoneProstaglandin E2 receptor EP4 subtypetarget
DB00917DinoprostoneProstaglandin E2 receptor EP3 subtypetarget
DB00917DinoprostoneSolute carrier family 22 member 2transporter
DB00917DinoprostoneMultidrug resistance-associated protein 5transporter
DB00917DinoprostoneSolute carrier family 22 member 6transporter
DB00917DinoprostoneSolute carrier family 22 member 8transporter
DB00917DinoprostoneSolute carrier family 22 member 11transporter
DB00917DinoprostoneSolute carrier family 22 member 7transporter
DB00917DinoprostoneMultidrug resistance-associated protein 4transporter
DB00917DinoprostoneSolute carrier organic anion transporter family member 2B1transporter
DB00917DinoprostoneSolute carrier organic anion transporter family member 1A2transporter
DB00917DinoprostoneOrganic solute transporter subunit alphatransporter
DB00917DinoprostoneOrganic solute transporter subunit betatransporter
DB00917DinoprostoneSolute carrier organic anion transporter family member 2A1transporter
DB00917DinoprostoneSolute carrier organic anion transporter family member 4A1transporter
DB00917DinoprostoneSolute carrier organic anion transporter family member 1C1transporter
DB00917DinoprostoneSolute carrier organic anion transporter family member 3A1transporter
DB00917DinoprostoneSolute carrier organic anion transporter family member 1B1transporter
DB00917DinoprostoneProstaglandin D2 receptor 2target
DB00929MisoprostolProstaglandin E2 receptor EP2 subtypetarget
DB00929MisoprostolProstaglandin E2 receptor EP3 subtypetarget
DB00929MisoprostolProstaglandin E2 receptor EP4 subtypetarget
DB00929MisoprostolProstaglandin E2 receptor EP1 subtypetarget
DB01046LubiprostoneChloride channel protein 2target
DB01046LubiprostoneCarbonyl reductase [NADPH] 1enzyme
DB01088IloprostProstacyclin receptortarget
DB01088IloprostTissue-type plasminogen activatortarget
DB01088IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DB01088IloprostSolute carrier organic anion transporter family member 2B1transporter
DB01088IloprostSolute carrier organic anion transporter family member 2A1transporter
DB01088IloprostSolute carrier organic anion transporter family member 3A1transporter
DB01088IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB01088IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Ctarget
DB01088IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
DB01088IloprostProstaglandin E2 receptor EP1 subtypetarget
DB01088IloprostProstaglandin D2 receptor 2target
DB01160Dinoprost tromethamineProstacyclin receptortarget
DB01160Dinoprost tromethamineProstaglandin F2-alpha receptortarget
DB01160Dinoprost tromethamineSolute carrier family 22 member 2transporter
DB01160Dinoprost tromethamineSolute carrier family 22 member 6transporter
DB01160Dinoprost tromethamineSolute carrier family 22 member 7transporter
DB01160Dinoprost tromethamineSolute carrier family 22 member 8transporter
DB01160Dinoprost tromethamineSolute carrier family 22 member 11transporter
DB01160Dinoprost tromethamineSolute carrier organic anion transporter family member 2A1transporter
DB01160Dinoprost tromethamineSolute carrier organic anion transporter family member 3A1transporter
DB01240EpoprostenolP2Y purinoceptor 12target
DB01240EpoprostenolProstacyclin receptortarget
DB01240EpoprostenolProstacyclin synthasetarget
DB01445BufotenineAmine oxidase [flavin-containing] Aenzyme
DB02261Platelet Activating FactorGanglioside GM2 activatortarget
DB02261Platelet Activating FactorP-glycoprotein 1transporter
DB02261Platelet Activating FactorPlatelet-activating factor receptortarget
DB03866Prostaglandin G2Prostaglandin G/H synthase 2target
DB04557Arachidonic AcidProstaglandin G/H synthase 1target
DB04557Arachidonic AcidSerum albumincarrier
DB04557Arachidonic AcidFatty acid-binding protein, adipocytecarrier
DB04557Arachidonic Acid14 kDa fatty acid-binding proteintarget
DB04557Arachidonic AcidFatty acid-binding protein, intestinalcarrier
DB04557Arachidonic AcidCytochrome P450 2C9enzyme
DB04557Arachidonic AcidSolute carrier organic anion transporter family member 2A1transporter
DB04557Arachidonic AcidPeroxisome proliferator-activated receptor alphatarget
DB04557Arachidonic AcidBile acid receptortarget
DB04557Arachidonic AcidRetinoic acid receptor RXR-alphatarget
DB04622N-ACETYLHISTAMINEGlutaminyl-peptide cyclotransferasetarget
DB05229BeraprostProstacyclin receptortarget
DB05229BeraprostCytochrome P450 2C8enzyme
DB05381HistamineHistamine H1 receptortarget
DB05381HistamineHistamine H2 receptortarget
DB05381HistamineHistamine H3 receptortarget
DB05381HistamineHistamine N-methyltransferaseenzyme
DB05381HistamineSolute carrier family 22 member 2transporter
DB05381HistamineSolute carrier family 22 member 1transporter
DB05381HistamineSolute carrier family 22 member 3transporter
DB05381HistamineSolute carrier family 22 member 5transporter
DB05381HistamineHistamine H4 receptortarget
DB05381HistamineSynaptic vesicular amine transportertarget
DB05514CobiprostoneChloride channel protein 2target
DB05934CTCE-0214Stromal cell-derived factor 1target
DB06196IcatibantB2 bradykinin receptortarget
DB06196IcatibantAminopeptidase Ntarget
DB06549LabradimilB2 bradykinin receptortarget
DB08819TafluprostProstaglandin F2-alpha receptortarget
DB08819TafluprostProstaglandin G/H synthase 2enzyme
DB08839SerotoninSolute carrier family 22 member 2transporter
DB08839SerotoninSodium-dependent serotonin transportertarget
DB08839Serotonin5-hydroxytryptamine receptor 2Atarget
DB08839Serotonin5-hydroxytryptamine receptor 3Atarget
DB08839Serotonin5-hydroxytryptamine receptor 3Btarget
DB08839SerotoninSynaptic vesicular amine transportertarget
DB08855Leukotriene C4Solute carrier organic anion transporter family member 1B1transporter
DB08855Leukotriene C4Solute carrier organic anion transporter family member 1B3transporter
DB08855Leukotriene C4Cysteinyl leukotriene receptor 1target
DB08855Leukotriene C4Cysteinyl leukotriene receptor 2target
DB08855Leukotriene C4Multidrug resistance-associated protein 1target
DB08964GemeprostProstaglandin E2 receptor EP2 subtypetarget
DB08964GemeprostProstaglandin E2 receptor EP3 subtypetarget
DB09211LimaprostProstaglandin E2 receptor EP1 subtypetarget
DB09211LimaprostProstaglandin E2 receptor EP2 subtypetarget
DB09211LimaprostProstaglandin E2 receptor EP3 subtypetarget
DB09211LimaprostProstaglandin E2 receptor EP4 subtypetarget
DB09539Omega-3-acid ethyl estersSterol O-acyltransferase 1enzyme
DB09539Omega-3-acid ethyl estersSterol regulatory element-binding protein 1target
DB11660Latanoprostene bunodProstaglandin F2-alpha receptortarget
DB11660Latanoprostene bunodSolute carrier organic anion transporter family member 2B1transporter
DB11842Angiotensin IIType-1 angiotensin II receptortarget
DB11858Leukotriene D4Cysteinyl leukotriene receptor 1target
DB11858Leukotriene D4Cysteinyl leukotriene receptor 2target
DB12789DinoprostProstaglandin D2 receptor 2target
DB12961Leukotriene B4Leukotriene B4 receptor 1target
DB12961Leukotriene B4Leukotriene B4 receptor 2target
DB12961Leukotriene B4Peroxisome proliferator-activated receptor alphatarget
DB02056Prostaglandin D2Aldo-keto reductase family 1 member C3target
DB02056Prostaglandin D2Solute carrier organic anion transporter family member 2A1transporter
DB02056Prostaglandin D2Prostaglandin D2 receptor 2target
DB04275N-acetylserotoninSepiapterin reductasetarget
DB00287TravoprostProstaglandin F2-alpha receptortarget
DB02465Methoxy arachidonyl fluorophosphonateFatty-acid amide hydrolase 1target
DB05875Sar9, Met (O2)11-Substance PCytochrome P450 19A1enzyme
DB05875Sar9, Met (O2)11-Substance PCholinesteraseenzyme
DB05875Sar9, Met (O2)11-Substance PProstaglandin G/H synthase 2enzyme