Benzyl Compounds

DrugDrug NameDrug Indication
DB00179MasoprocolUsed for the treatment of actinic keratoses (precancerous skin growths that can become malignant if left untreated).
DB00773EtoposideFor use in combination with other chemotherapeutic agents in the treatment of refractory testicular tumors and as first line treatment in patients with small cell lung cancer. Also used to treat other malignancies such as lymphoma, non-lymphocytic leukemia, and glioblastoma multiforme.
DB01091ButenafineFor the topical treatment of the following dermatologic infections: tinea (pityriasis) versicolor due to M. furfur, interdigital tinea pedis (athlete’s foot), tinea corporis (ringworm) and tinea cruris (jock itch) due to E. floccosum, T. mentagrophytes, T. rubrum, and T. tonsurans.
DB01179PodofiloxFor treatment of external genital warts (Condyloma acuminatum).
DB01626PargylineFor the treatment of moderate to severe hypertension.
DB017112,3,4,5,6-Pentafluorobenzyl AlcoholNot Available
DB02044N-(3-(Aminomethyl)Benzyl)AcetamidineNot Available
DB02464BenzylamineNot Available
DB02822Para-Bromobenzyl AlcoholNot Available
DB030582-Aminobenzyl alcoholNot Available
DB04200MatairesinolNot Available
DB04884DapoxetineFor the treatment of premature ejaculation.
DB04898XimelagatranFor the treatment of acute deep vein thrombosis.
DB06654SafinamideSafinamide is indicated as an add-on treatment to levodopa with or without other medicines for Parkinson’s disease
DB06770Benzyl alcoholUlesfia (benzyl alcohol) lotion is indicated for the topical treatment of head lice infestation in patients 6 months of age and older. Ulesfia Lotion does not have ovicidal activity.
DB09082VilanterolVilanterol is approved for use in several combination products such as with fluticasone furoate under the tradename Breo Ellipta and in combination with umeclidinium bromide as Anoro Ellipta. Approved by the FDA in 2013, use of Breo Ellipta is indicated for the long-term, once-daily maintenance treatment of airflow obstruction in patients with COPD, including chronic bronchitis and emphysema. It is also indicated for once-daily maintenance treatment of asthma in patients aged 18 or older with reversible obstructive airways disease.
DB11957IdalopirdineNot Available
DB12087Vanillyl alcoholNot Available
DB12179SecoisolariciresinolNot Available
DB12226TerameprocolNot Available
DB12585OndelopranNot Available
DB12596CombretastatinNot Available
DB12802PicropodophyllinNot Available
DB13205TeclozanNot Available
DB13269Dichlorobenzyl alcoholDichlorobenzyl alcohol in combination with [DB13908] is available in over-the-counter products used for symptomatic relief of acute sore throat and postoperative sore throat.[A27155]
DB13616MelagatranNot Available
DB14129MacelignanNot Available
DB09298SilibininCurrently being tested as a treatment of severe intoxications with hepatotoxic substances, such as death cap (Amanita phalloides) poisoning.
DB148552-(aminomethyl)phenolNot Available
DrugDrug NameTargetType
DB00179MasoprocolArachidonate 5-lipoxygenasetarget
DB00179MasoprocolCytochrome P450 2J2enzyme
DB00179MasoprocolSex hormone-binding globulintarget
DB00773EtoposideDNA topoisomerase 2-alphatarget
DB00773EtoposideCytochrome P450 3A4enzyme
DB00773EtoposideCanalicular multispecific organic anion transporter 2transporter
DB00773EtoposideMultidrug resistance-associated protein 6transporter
DB00773EtoposideMultidrug resistance protein 1transporter
DB00773EtoposideMultidrug resistance-associated protein 1transporter
DB00773EtoposideMultidrug resistance-associated protein 7transporter
DB00773EtoposideCanalicular multispecific organic anion transporter 1transporter
DB00773EtoposideATP-binding cassette sub-family G member 2transporter
DB00773EtoposideCytochrome P450 1A2enzyme
DB00773EtoposideCytochrome P450 2C8enzyme
DB00773EtoposideCytochrome P450 2E1enzyme
DB00773EtoposideCytochrome P450 3A5enzyme
DB00773EtoposideUDP-glucuronosyltransferase 1-1enzyme
DB00773EtoposideDNA topoisomerase 2-betatarget
DB00773EtoposideGlutathione S-transferase theta-1enzyme
DB00773EtoposideGlutathione S-transferase Penzyme
DB00773EtoposideProstaglandin G/H synthase 2enzyme
DB00773EtoposideProstaglandin G/H synthase 1enzyme
DB01091ButenafineSqualene monooxygenasetarget
DB01179PodofiloxDNA topoisomerase 2-alphatarget
DB01179PodofiloxTubulin alpha-4A chaintarget
DB01179PodofiloxTubulin beta chaintarget
DB01626PargylineAmine oxidase [flavin-containing] Btarget
DB01626PargylineAmine oxidase [flavin-containing] Atarget
DB017112,3,4,5,6-Pentafluorobenzyl AlcoholAlcohol dehydrogenase 1Ctarget
DB02044N-(3-(Aminomethyl)Benzyl)AcetamidineNitric oxide synthase, endothelialtarget
DB02044N-(3-(Aminomethyl)Benzyl)AcetamidineNitric oxide synthase, inducibletarget
DB02044N-(3-(Aminomethyl)Benzyl)AcetamidineNitric oxide synthase, braintarget
DB02464BenzylamineTrypsin-1target
DB02464BenzylamineTrypsin-2target
DB02822Para-Bromobenzyl AlcoholAlcohol dehydrogenase 1Ctarget
DB030582-Aminobenzyl alcoholComplement factor Dtarget
DB04200MatairesinolDehydrogenase/reductase SDR family member 4-like 2target
DB04884Dapoxetine5-hydroxytryptamine receptor 1Atarget
DB04884Dapoxetine5-hydroxytryptamine receptor 1Btarget
DB04884Dapoxetine5-hydroxytryptamine receptor 2Ctarget
DB04884DapoxetineCytochrome P450 3A4enzyme
DB04884DapoxetineCytochrome P450 2D6enzyme
DB04898XimelagatranProthrombintarget
DB04898XimelagatranCytochrome P450 2C9enzyme
DB06654SafinamideAmine oxidase [flavin-containing] Btarget
DB06654SafinamideAmine oxidase [flavin-containing] Aenzyme
DB06654SafinamideATP-binding cassette sub-family G member 2transporter
DB06654SafinamideSolute carrier organic anion transporter family member 3A1transporter
DB06654SafinamideCytochrome P450 3A4enzyme
DB06654SafinamideCytochrome P450 1A1enzyme
DB06654SafinamideCytochrome P450 1A2enzyme
DB06654SafinamideCytochrome P450 2B6enzyme
DB06654SafinamideCytochrome P450 2C9enzyme
DB06654SafinamideCytochrome P450 2D6enzyme
DB06654SafinamideCytochrome P450 2C19enzyme
DB06654SafinamideCytochrome P450 2E1enzyme
DB06654SafinamideCytochrome P450 3A5enzyme
DB06770Benzyl alcoholCytochrome P450 2C8enzyme
DB06770Benzyl alcoholCytochrome P450 1A1enzyme
DB06770Benzyl alcoholAldehyde dehydrogenase, mitochondrialenzyme
DB06770Benzyl alcoholCytochrome P450 1A2enzyme
DB06770Benzyl alcoholCytochrome P450 2E1enzyme
DB06770Benzyl alcoholCytochrome P450 2D6enzyme
DB09082VilanterolCytochrome P450 3A4enzyme
DB09082VilanterolBeta-2 adrenergic receptortarget
DB13269Dichlorobenzyl alcoholSodium channel proteintarget
DB09298SilibininSolute carrier family 22 member 6transporter
DB09298SilibininUDP-glucuronosyltransferase 1-1enzyme
DB09298SilibininSolute carrier organic anion transporter family member 1B1transporter
DB09298SilibininSolute carrier organic anion transporter family member 1B3transporter
DB09298SilibininSolute carrier organic anion transporter family member 2B1transporter