Identification

Name
Benzyl alcohol
Accession Number
DB06770
Type
Small Molecule
Groups
Approved
Description
Not Available
Structure
Thumb
Synonyms
  • (hydroxymethyl)benzene
  • Alcoholum benzylicum
  • Alcool benzylique
  • Alcoolbenzylique
  • alpha-Hydroxytoluene
  • Aromatic alcohol
  • Bentalol
  • Benzalalcohol
  • Benzalcohol
  • Benzenecarbinol
  • Benzenemethanol
  • Benzoyl alcohol
  • Benzyl alcohol
  • Benzylalkohol
  • Benzylic alcohol
  • Hydroxymethylbenzene
  • Phenylcarbinol
  • Phenylmethanol
  • Phenylmethyl alcohol
  • α-toluenol
External IDs
E-1519 / FEMA NO. 2137 / INS NO.1519 / INS-1519 / NSC-8044
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
UlesfiaLotion50 mg/1gTopicalShionogi2009-05-262016-04-30Us
UlesfiaLotion50 mg/1gTopicalLachlan Pharmaceuticals2015-08-17Not applicableUs
UlesfiaLotion50 mg/1gTopicalConcordia Pharmaceuticals, Inc2009-05-262016-07-22Us
UlesfiaLotion50 mg/1gTopicalZylera Pharmaceuticals, LLC2014-07-16Not applicableUs
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
AverteaxCream10 mg/1gTopicalCamellix, LLC2014-01-01Not applicableUs
Baby's Own Teething Gel - 2.5%Gel2.5 %TopicalBlock Drug Company (Canada) Ltd.1998-03-022001-03-14Canada
Baby's Own Teething Gel 2.5%Gel2.5 %TopicalDannorth Laboratories Inc.1990-12-311997-08-12Canada
Babys Own Gora Teething LotLotion25 mgDentalG.T. Fulford Pharmaceuticals1961-12-311998-06-25Canada
Babys Own Teething GelGel25 mgDentalG.T. Fulford Pharmaceuticals1977-12-311998-06-25Canada
ProtocoxilGel100 mg/1gTopicalBio ekuiliber llc2017-05-09Not applicableUs
ProtocoxilGel100 mg/1gTopicalBio ekuiliber llc2017-05-09Not applicableUs
Zilactin Early Relief Cold SoreGel0.1 g/1gTopicalBlairex Laboratories, Inc.2005-06-30Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
biochemistry PAIN RELIEF FOOT ACTIVEBenzyl alcohol (190 mg/1mL) + Lidocaine hydrochloride (40 mg/1mL)LiquidTopicalPure Source, Llc2014-02-06Not applicableUs
CiproBenzyl alcohol (9 mg/1mL) + Ciprofloxacin hydrochloride (2 mg/1mL) + Hydrocortisone (10 mg/1mL)SuspensionAuricular (otic)Physicians Total Care, Inc.2009-02-12Not applicableUs
Cipro HCBenzyl alcohol (9 mg/1mL) + Ciprofloxacin hydrochloride (2 mg/1mL) + Hydrocortisone (10 mg/1mL)SuspensionAuricular (otic)Stat Rx USA1998-02-10Not applicableUs
Denture Orajel GelBenzyl alcohol (1 %) + Benzocaine (7.5 %) + Clove oil (0.2 %)GelBuccal; TopicalCommerce Pharmaceutics Inc.1997-12-172004-07-20Canada
EnbrelBenzyl alcohol (9.93 mg/1mL) + Etanercept (25 mg/1mL)KitPhysicians Total Care, Inc.2003-04-302012-06-30Us
Foille OntBenzyl alcohol (4 %) + Benzocaine (2 %)OintmentTopicalBlistex Corporation1980-12-312007-07-10Canada
Itch XBenzyl alcohol (10 g/100g) + Pramoxine hydrochloride (1 g/100g)GelTopicalBF ASCHER AND CO INC2014-09-19Not applicableUs
Itch X GelBenzyl alcohol (10 %) + Pramoxine hydrochloride (1 %)GelTopicalB.F. Ascher & Company Inc.1994-12-311998-07-09Canada
Itch-XBenzyl alcohol (10 g/100mL) + Pramoxine hydrochloride (1 g/100mL)SprayTopicalBF ASCHER AND CO INC2014-09-19Not applicableUs
Itch-X GelBenzyl alcohol (10 %) + Pramoxine hydrochloride (1 %)GelTopicalB.F. Ascher & Company Inc.1994-12-312002-07-09Canada
Categories
UNII
LKG8494WBH
CAS number
100-51-6
Weight
Average: 108.1378
Monoisotopic: 108.057514878
Chemical Formula
C7H8O
InChI Key
WVDDGKGOMKODPV-UHFFFAOYSA-N
InChI
InChI=1S/C7H8O/c8-6-7-4-2-1-3-5-7/h1-5,8H,6H2
IUPAC Name
phenylmethanol
SMILES
OCC1=CC=CC=C1

Pharmacology

Indication

Ulesfia (benzyl alcohol) lotion is indicated for the topical treatment of head lice infestation in patients 6 months of age and older. Ulesfia Lotion does not have ovicidal activity.

Associated Conditions
Pharmacodynamics
Not Available
Mechanism of action

Benzyl alcohol inhibits lice from closing their respiratory spiracles, allowing the vehicle to obstruct the spiracles and causing the lice to asphyxiate.

Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity

1250 mg/kg (rat, oral) LD50 400 mg/kg IPR-RAT LD50 2000 mg/kg SKN-RBT LD50 53 mg/kg IVN-RAT LD50 2500 mg/kg ORL-GPG LD50

Affected organisms
  • Head lice
Pathways
PathwayCategory
Glycerol Metabolism V (Glycerophosphoserine)Metabolic
Hexuronide and Hexuronate DegradationMetabolic
Glycerol Metabolism IIMetabolic
Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine)Metabolic
Glycerol Metabolism IV (Glycerophosphoglycerol)Metabolic
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
(R)-warfarinThe metabolism of (R)-warfarin can be decreased when combined with Benzyl alcohol.
(S)-WarfarinThe metabolism of (S)-Warfarin can be decreased when combined with Benzyl alcohol.
2,5-Dimethoxy-4-ethylthioamphetamineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with 2,5-Dimethoxy-4-ethylthioamphetamine.
3-isobutyl-1-methyl-7H-xanthineThe serum concentration of 3-isobutyl-1-methyl-7H-xanthine can be increased when it is combined with Benzyl alcohol.
3,4-MethylenedioxyamphetamineThe risk or severity of adverse effects can be increased when 3,4-Methylenedioxyamphetamine is combined with Benzyl alcohol.
4-Bromo-2,5-dimethoxyamphetamineThe risk or severity of adverse effects can be increased when 4-Bromo-2,5-dimethoxyamphetamine is combined with Benzyl alcohol.
4-MethoxyamphetamineThe risk or severity of adverse effects can be increased when 4-Methoxyamphetamine is combined with Benzyl alcohol.
5-methoxy-N,N-dimethyltryptamineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with 5-methoxy-N,N-dimethyltryptamine.
6-O-benzylguanineThe serum concentration of 6-O-benzylguanine can be increased when it is combined with Benzyl alcohol.
7-DeazaguanineThe serum concentration of 7-Deazaguanine can be increased when it is combined with Benzyl alcohol.
Food Interactions
Not Available

References

Synthesis Reference

Cornelis Jongsma, Leon H. B. Frijns, Paula A. M. Raven-Donners, "Method for the preparation of a pure alkali metal benzoate and benzyl alcohol." U.S. Patent US4296245, issued June, 1940.

US4296245
General References
  1. Taylor PM, Chengelis CP, Miller WR, Parker GA, Gleason TR, Cozzi E: Evaluation of propofol containing 2% benzyl alcohol preservative in cats. J Feline Med Surg. 2012 Aug;14(8):516-26. doi: 10.1177/1098612X12440354. Epub 2012 Feb 24. [PubMed:22366290]
  2. Novak E, Stubbs SS, Sanborn EC, Eustice RM: The tolerance and safety of intravenously administered benzyl alcohol in methylprednisolone sodium succinate formulations in normal human subjects. Toxicol Appl Pharmacol. 1972 Sep;23(1):54-61. [PubMed:4560999]
  3. Meinking TL, Villar ME, Vicaria M, Eyerdam DH, Paquet D, Mertz-Rivera K, Rivera HF, Hiriart J, Reyna S: The clinical trials supporting benzyl alcohol lotion 5% (Ulesfia): a safe and effective topical treatment for head lice (pediculosis humanus capitis). Pediatr Dermatol. 2010 Jan-Feb;27(1):19-24. doi: 10.1111/j.1525-1470.2009.01059.x. [PubMed:20199404]
External Links
Human Metabolome Database
HMDB0003119
KEGG Drug
D00077
KEGG Compound
C03485
PubChem Compound
244
PubChem Substance
175427090
ChemSpider
13860335
ChEBI
17987
ChEMBL
CHEMBL720
PharmGKB
PA448594
HET
010
RxList
RxList Drug Page
Wikipedia
Benzyl_alcohol
ATC Codes
P03AX06 — Benzyl alcohol
PDB Entries
2amq / 2hob / 2q6f / 3d23 / 3iwm / 4ii8 / 5eb5 / 5eu8 / 5gwy / 5gwz
show 2 more
FDA label
Download (1.05 MB)
MSDS
Download (50.6 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedTreatmentOtitis Externa1
3CompletedTreatmentLice of the head1
4CompletedTreatmentHip Pain1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
CreamTopical10 mg/1g
GelTopical2.5 %
LotionDental25 mg
GelDental25 mg
SuspensionAuricular (otic)
GelBuccal; Topical
Kit
OintmentTopical
GelTopical
CreamTopical
SprayTopical
Aerosol, sprayTopical
SolutionOral
GelTopical100 mg/1g
CreamPercutaneous; Topical; Transdermal
LiquidPercutaneous; Topical; Transdermal
LiquidTopical
LotionTopical50 mg/1g
GelTopical0.1 g/1g
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5858383No1999-01-122017-08-11Us
US6139859No2000-10-312017-08-11Us
US6793931No2004-09-212022-07-11Us
US7294342No2007-11-132024-05-19Us

Properties

State
Liquid
Experimental Properties
PropertyValueSource
melting point (°C)-15..2 °C, 258 K, 5 °F# http://sitem.herts.ac.uk/aeru/footprint/en/Reports/953.htm.
boiling point (°C)205.3 °C, 478 K, 402 °F# http://sitem.herts.ac.uk/aeru/footprint/en/Reports/953.htm.
water solubility33 mg/mL, clear, colorless# http://www.chemicalbook.com/ProductChemicalPropertiesCB3852587_EN.htm
logP1.1# http://sitem.herts.ac.uk/aeru/footprint/en/Reports/953.htm.
pKa15.4# http://sitem.herts.ac.uk/aeru/footprint/en/Reports/953.htm.
Predicted Properties
PropertyValueSource
Water Solubility26.8 mg/mLALOGPS
logP1.07ALOGPS
logP1.21ChemAxon
logS-0.61ALOGPS
pKa (Strongest Acidic)15.02ChemAxon
pKa (Strongest Basic)-2.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area20.23 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity32.87 m3·mol-1ChemAxon
Polarizability11.89 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9906
Blood Brain Barrier+0.9698
Caco-2 permeable+0.8859
P-glycoprotein substrateNon-substrate0.8373
P-glycoprotein inhibitor INon-inhibitor0.9803
P-glycoprotein inhibitor IINon-inhibitor0.9629
Renal organic cation transporterNon-inhibitor0.8259
CYP450 2C9 substrateNon-substrate0.7995
CYP450 2D6 substrateNon-substrate0.9234
CYP450 3A4 substrateNon-substrate0.8408
CYP450 1A2 substrateInhibitor0.5434
CYP450 2C9 inhibitorNon-inhibitor0.9285
CYP450 2D6 inhibitorNon-inhibitor0.9623
CYP450 2C19 inhibitorNon-inhibitor0.7859
CYP450 3A4 inhibitorNon-inhibitor0.9558
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8458
Ames testNon AMES toxic0.9645
CarcinogenicityNon-carcinogens0.5381
BiodegradationReady biodegradable0.8774
Rat acute toxicity1.9753 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8998
hERG inhibition (predictor II)Non-inhibitor0.9625
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Download (7.19 KB)
Spectra
SpectrumSpectrum TypeSplash Key
GC-MS Spectrum - GC-MS (1 TMS)GC-MSsplash10-00ko-6900000000-a9d668ecd37a1579a6fe
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
GC-MS Spectrum - EI-BGC-MSsplash10-056r-9400000000-77cec715500da9c57a84
GC-MS Spectrum - EI-BGC-MSsplash10-056r-9400000000-8dc38068387df3fa06aa
GC-MS Spectrum - EI-BGC-MSsplash10-056r-9300000000-fb124b56257906cce9f1
GC-MS Spectrum - EI-BGC-MSsplash10-056r-9400000000-7a77e67486ae3b2dd855
GC-MS Spectrum - EI-BGC-MSsplash10-056r-9400000000-dd0878988e7c2d9a5431
GC-MS Spectrum - GC-MSGC-MSsplash10-00ko-6900000000-a9d668ecd37a1579a6fe
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-0006-8900000000-c256b0b7a0755f08ac64
Mass Spectrum (Electron Ionization)MSsplash10-056r-9400000000-a8f1fd78fa3f8781f296
MS/MS Spectrum - Quattro_QQQ 10V, N/A (Annotated)LC-MS/MSsplash10-0a4i-9500000000-2a82c3dd7c6871f61c34
MS/MS Spectrum - Quattro_QQQ 25V, N/A (Annotated)LC-MS/MSsplash10-0006-9000000000-ad1762d5292c30b29bbd
MS/MS Spectrum - Quattro_QQQ 40V, N/ALC-MS/MSsplash10-0006-9000000000-3c8d4c630cf42e3bfd3f
MS/MS Spectrum - EI-B (HITACHI RMU-7M) , PositiveLC-MS/MSsplash10-056r-9400000000-c4dcb2148958f946cd01
MS/MS Spectrum - EI-B (HITACHI RMU-6M) , PositiveLC-MS/MSsplash10-056r-9400000000-e17e577dbe4546313a91
MS/MS Spectrum - EI-B (JEOL JMS-01-SG-2) , PositiveLC-MS/MSsplash10-056r-9300000000-fb124b56257906cce9f1
MS/MS Spectrum - EI-B (HITACHI M-80) , PositiveLC-MS/MSsplash10-056r-9400000000-47b3605316c57e02b84f
MS/MS Spectrum - EI-B (HITACHI M-80B) , PositiveLC-MS/MSsplash10-056r-9400000000-dd0878988e7c2d9a5431
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0a4i-0900000000-3a71c23796a048eb999c
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0a4i-1900000000-40737e7bdf548d714249
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0uxr-9100000000-23e82914cfa9372ecafc
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0a4i-1900000000-17f95f5a398b5850abb2
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0a6r-7900000000-733d283e0916e755a736
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-9000000000-d0c6e5fc39516ee594b4
MS/MS Spectrum - , positiveLC-MS/MSsplash10-0a4i-3900000000-4d1bf15f6cf8f65bf0a6
1H NMR Spectrum1D NMRNot Applicable
1H NMR Spectrum1D NMRNot Applicable
13C NMR Spectrum1D NMRNot Applicable
1H NMR Spectrum1D NMRNot Applicable
13C NMR Spectrum1D NMRNot Applicable
[1H,13C] 2D NMR Spectrum2D NMRNot Applicable

Taxonomy

Description
This compound belongs to the class of organic compounds known as benzyl alcohols. These are organic compounds containing the phenylmethanol substructure.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Benzyl alcohols
Direct Parent
Benzyl alcohols
Alternative Parents
Primary alcohols / Hydrocarbon derivatives / Aromatic alcohols
Substituents
Benzyl alcohol / Organic oxygen compound / Hydrocarbon derivative / Aromatic alcohol / Primary alcohol / Organooxygen compound / Alcohol / Aromatic homomonocyclic compound
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
benzyl alcohols (CHEBI:17987) / an aromatic compound (BENZYL-ALCOHOL)

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C8
Uniprot ID
P10632
Uniprot Name
Cytochrome P450 2C8
Molecular Weight
55824.275 Da
References
  1. Nakajima T, Wang RS, Elovaara E, Gonzalez FJ, Gelboin HV, Raunio H, Pelkonen O, Vainio H, Aoyama T: Toluene metabolism by cDNA-expressed human hepatic cytochrome P450. Biochem Pharmacol. 1997 Feb 7;53(3):271-7. [PubMed:9065730]
  2. Kim H, Wang RS, Elovaara E, Raunio H, Pelkonen O, Aoyama T, Vainio H, Nakajima T: Cytochrome P450 isozymes responsible for the metabolism of toluene and styrene in human liver microsomes. Xenobiotica. 1997 Jul;27(7):657-65. [PubMed:9253143]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Vitamin d 24-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A1
Uniprot ID
P04798
Uniprot Name
Cytochrome P450 1A1
Molecular Weight
58164.815 Da
References
  1. Furman GM, Silverman DM, Schatz RA: Inhibition of rat lung mixed-function oxidase activity following repeated low-level toluene inhalation: possible role of toluene metabolites. J Toxicol Environ Health A. 1998 Aug 21;54(8):633-45. [PubMed:9726784]
  2. Nakajima T, Wang RS, Elovaara E, Gonzalez FJ, Gelboin HV, Raunio H, Pelkonen O, Vainio H, Aoyama T: Toluene metabolism by cDNA-expressed human hepatic cytochrome P450. Biochem Pharmacol. 1997 Feb 7;53(3):271-7. [PubMed:9065730]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Electron carrier activity
Specific Function
Not Available
Gene Name
ALDH2
Uniprot ID
P05091
Uniprot Name
Aldehyde dehydrogenase, mitochondrial
Molecular Weight
56380.93 Da
References
  1. Kawamoto T, Koga M, Murata K, Matsuda S, Kodama Y: Effects of ALDH2, CYP1A1, and CYP2E1 genetic polymorphisms and smoking and drinking habits on toluene metabolism in humans. Toxicol Appl Pharmacol. 1995 Aug;133(2):295-304. [PubMed:7645026]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A2
Uniprot ID
P05177
Uniprot Name
Cytochrome P450 1A2
Molecular Weight
58293.76 Da
References
  1. Nakajima T, Wang RS, Elovaara E, Gonzalez FJ, Gelboin HV, Raunio H, Pelkonen O, Vainio H, Aoyama T: Toluene metabolism by cDNA-expressed human hepatic cytochrome P450. Biochem Pharmacol. 1997 Feb 7;53(3):271-7. [PubMed:9065730]
  2. Kim H, Wang RS, Elovaara E, Raunio H, Pelkonen O, Aoyama T, Vainio H, Nakajima T: Cytochrome P450 isozymes responsible for the metabolism of toluene and styrene in human liver microsomes. Xenobiotica. 1997 Jul;27(7):657-65. [PubMed:9253143]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic ...
Gene Name
CYP2E1
Uniprot ID
P05181
Uniprot Name
Cytochrome P450 2E1
Molecular Weight
56848.42 Da
References
  1. Nakajima T, Wang RS, Elovaara E, Gonzalez FJ, Gelboin HV, Raunio H, Pelkonen O, Vainio H, Aoyama T: Toluene metabolism by cDNA-expressed human hepatic cytochrome P450. Biochem Pharmacol. 1997 Feb 7;53(3):271-7. [PubMed:9065730]
  2. Lipscomb JC, Barton HA, Tornero-Velez R, Evans MV, Alcasey S, Snawder JE, Laskey J: The metabolic rate constants and specific activity of human and rat hepatic cytochrome P-450 2E1 toward toluene and chloroform. J Toxicol Environ Health A. 2004 Apr 9;67(7):537-53. [PubMed:15129551]
  3. Kim H, Wang RS, Elovaara E, Raunio H, Pelkonen O, Aoyama T, Vainio H, Nakajima T: Cytochrome P450 isozymes responsible for the metabolism of toluene and styrene in human liver microsomes. Xenobiotica. 1997 Jul;27(7):657-65. [PubMed:9253143]
  4. Wang RS, Nakajima T, Park SS, Gelboin HV, Murayama N: Monoclonal antibody-directed assessment of toluene induction of rat hepatic cytochrome P450 isozymes. Biochem Pharmacol. 1993 Aug 3;46(3):413-9. [PubMed:8347164]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...
Gene Name
CYP2D6
Uniprot ID
P10635
Uniprot Name
Cytochrome P450 2D6
Molecular Weight
55768.94 Da
References
  1. Obach RS: Mechanism of cytochrome P4503A4- and 2D6-catalyzed dehydrogenation of ezlopitant as probed with isotope effects using five deuterated analogs. Drug Metab Dispos. 2001 Dec;29(12):1599-607. [PubMed:11717179]

Drug created on September 14, 2010 10:21 / Updated on December 14, 2018 05:41