Identification

Name
Benzyl alcohol
Accession Number
DB06770
Type
Small Molecule
Groups
Approved
Description
Not Available
Structure
Thumb
Synonyms
  • (Hydroxymethyl)benzene
  • Alcoholum benzylicum
  • Alcool benzylique
  • Alcoolbenzylique
  • alpha-Hydroxytoluene
  • alpha-Toluenol
  • Aromatic alcohol
  • Bentalol
  • Benzalalcohol
  • Benzalcohol
  • Benzenecarbinol
  • Benzenemethanol
  • Benzoyl alcohol
  • Benzyl alcohol
  • Benzylalkohol
  • Benzylic alcohol
  • Hydroxymethylbenzene
  • Phenylcarbinol
  • Phenylmethanol
  • Phenylmethyl alcohol
External IDs
E-1519 / FEMA NO. 2137 / INS NO.1519 / INS-1519 / NSC-8044
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
UlesfiaLotion50 mg/gTopicalZylera Pharmaceuticals, LLC2014-07-16Not applicableUs
UlesfiaLotion50 mg/gTopicalLachlan Pharmaceuticals2015-08-17Not applicableUs
UlesfiaLotion50 mg/gTopicalConcordia Pharmaceuticals, Inc2009-05-262016-10-13Us
UlesfiaLotion50 mg/gTopicalShionogi2009-05-262016-10-13Us
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
AverteaxCream10 mg/gTopicalCamellix, LLC2014-01-01Not applicableUs
Baby's Own Teething Gel - 2.5%Gel2.5 %TopicalBlock Drug Company (Canada) Ltd.1998-03-022001-03-14Canada
Baby's Own Teething Gel 2.5%Gel2.5 %TopicalDannorth Laboratories Inc.1990-12-311997-08-12Canada
Babys Own Gora Teething LotLotion25 mgDentalG.T. Fulford Pharmaceuticals1961-12-311998-06-25Canada
Babys Own Teething GelGel25 mgDentalG.T. Fulford Pharmaceuticals1977-12-311998-06-25Canada
ProtocoxilGel100 mg/gTopicalBio ekuiliber llc2017-05-09Not applicableUs
ProtocoxilGel100 mg/gTopicalBio ekuiliber llc2017-05-09Not applicableUs
Zilactin Early Relief Cold SoreGel.1 g/gTopicalBlairex Laboratories, Inc.2005-06-30Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
biochemistry PAIN RELIEF FOOT ACTIVEBenzyl alcohol (190 mg/mL) + Lidocaine hydrochloride (40 mg/mL)LiquidTopicalPure Source, Llc2014-02-06Not applicableUs
Cipro HCBenzyl alcohol (9 mg/mL) + Ciprofloxacin (2 mg/mL) + Hydrocortisone (10 mg/mL)SuspensionAuricular (otic)Stat Rx USA1998-02-10Not applicableUs
Denture Orajel GelBenzyl alcohol (1 %) + Benzocaine (7.5 %) + Clove oil (0.2 %)GelBuccal; TopicalCommerce Pharmaceutics Inc.1997-12-172004-07-20Canada
Foille OntBenzyl alcohol (4 %) + Benzocaine (2 %)OintmentTopicalBlistex Corporation1980-12-312007-07-10Canada
Itch XBenzyl alcohol (10 g/100g) + Pramoxine hydrochloride (1 g/100g)GelTopicalBF ASCHER AND CO INC2014-09-19Not applicableUs
Itch X GelBenzyl alcohol (10 %) + Pramoxine hydrochloride (1 %)GelTopicalB.F. Ascher & Company Inc.1994-12-311998-07-09Canada
Itch-XBenzyl alcohol (10 g/100mL) + Pramoxine hydrochloride (1 g/100mL)SprayTopicalBF ASCHER AND CO INC2014-09-19Not applicableUs
Itch-X GelBenzyl alcohol (10 %) + Pramoxine hydrochloride (1 %)GelTopicalB.F. Ascher & Company Inc.1994-12-312002-07-09Canada
IvarestBenzyl alcohol (10.5 g/100g) + Diphenhydramine hydrochloride (2 g/100g) + Zinc oxide (14 g/100g)CreamTopicalBlistex Corporation2007-12-31Not applicableUs
Ivy DryBenzyl alcohol (10 g/100g) + Camphor (.6 g/100g) + Menthol (.4 g/100g)CreamTopicalIvy Dry, Inc.2012-08-22Not applicableUs
Categories
UNII
LKG8494WBH
CAS number
100-51-6
Weight
Average: 108.1378
Monoisotopic: 108.057514878
Chemical Formula
C7H8O
InChI Key
WVDDGKGOMKODPV-UHFFFAOYSA-N
InChI
InChI=1S/C7H8O/c8-6-7-4-2-1-3-5-7/h1-5,8H,6H2
IUPAC Name
phenylmethanol
SMILES
OCC1=CC=CC=C1

Pharmacology

Indication

Ulesfia (benzyl alcohol) lotion is indicated for the topical treatment of head lice infestation in patients 6 months of age and older. Ulesfia Lotion does not have ovicidal activity.

Structured Indications
Pharmacodynamics
Not Available
Mechanism of action

Benzyl alcohol inhibits lice from closing their respiratory spiracles, allowing the vehicle to obstruct the spiracles and causing the lice to asphyxiate.

Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity

1250 mg/kg (rat, oral) LD50 400 mg/kg IPR-RAT LD50 2000 mg/kg SKN-RBT LD50 53 mg/kg IVN-RAT LD50 2500 mg/kg ORL-GPG LD50

Affected organisms
  • Head lice
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Benzyl alcohol.Experimental
AbirateroneThe serum concentration of Benzyl alcohol can be increased when it is combined with Abiraterone.Approved
AcepromazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Benzyl alcohol.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Benzyl alcohol.Approved
AdipiplonThe risk or severity of adverse effects can be increased when Adipiplon is combined with Benzyl alcohol.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Benzyl alcohol.Approved, Investigational
AlaproclateThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Alaproclate.Experimental
AlfaxaloneThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Alfaxalone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Benzyl alcohol.Approved, Illicit
AllopregnanoloneThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Allopregnanolone.Investigational
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Benzyl alcohol.Experimental, Illicit
AlphaprodineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Alphaprodine.Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Benzyl alcohol.Approved, Illicit, Investigational
AmiodaroneThe metabolism of Benzyl alcohol can be decreased when combined with Amiodarone.Approved, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Amisulpride is combined with Benzyl alcohol.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Amitriptyline.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Benzyl alcohol.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Amoxapine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Amperozide.Experimental
AprepitantThe serum concentration of Benzyl alcohol can be increased when it is combined with Aprepitant.Approved, Investigational
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Benzyl alcohol.Approved, Investigational
ArtemetherThe metabolism of Benzyl alcohol can be decreased when combined with Artemether.Approved
ArticaineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Articaine.Approved
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Benzyl alcohol.Approved
AtazanavirThe metabolism of Benzyl alcohol can be decreased when combined with Atazanavir.Approved, Investigational
AtomoxetineThe metabolism of Benzyl alcohol can be decreased when combined with Atomoxetine.Approved
AzaperoneThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Azaperone.Investigational, Vet Approved
AzelastineBenzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
AzithromycinThe metabolism of Benzyl alcohol can be decreased when combined with Azithromycin.Approved
BaclofenThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Baclofen.Approved
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Benzyl alcohol.Illicit
BenperidolThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Benperidol.Investigational
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Benzyl alcohol.Approved
BetaxololThe metabolism of Benzyl alcohol can be decreased when combined with Betaxolol.Approved
BoceprevirThe metabolism of Benzyl alcohol can be decreased when combined with Boceprevir.Approved, Withdrawn
BortezomibThe metabolism of Benzyl alcohol can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Benzyl alcohol can be decreased when it is combined with Bosentan.Approved, Investigational
BrexpiprazoleThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Brexpiprazole.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Benzyl alcohol.Approved
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Benzyl alcohol.Approved, Illicit
BromisovalThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Bromisoval.Experimental
BromperidolThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Bromperidol.Investigational
BrompheniramineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Brompheniramine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Brotizolam.Approved, Investigational, Withdrawn
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Benzyl alcohol.Approved, Investigational
BuprenorphineBenzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Benzyl alcohol can be decreased when combined with Bupropion.Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Benzyl alcohol.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Benzyl alcohol.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Butacaine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Butalbital.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Butamben.Approved
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Benzyl alcohol.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Benzyl alcohol.Approved, Illicit, Vet Approved
CaffeineThe metabolism of Benzyl alcohol can be decreased when combined with Caffeine.Approved
CanertinibThe risk or severity of adverse effects can be increased when Canertinib is combined with Benzyl alcohol.Investigational
CarbamazepineThe metabolism of Benzyl alcohol can be increased when combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Carbinoxamine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Benzyl alcohol.Illicit, Investigational, Vet Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Carisoprodol.Approved
CelecoxibThe metabolism of Benzyl alcohol can be decreased when combined with Celecoxib.Approved, Investigational
CeritinibThe serum concentration of Benzyl alcohol can be increased when it is combined with Ceritinib.Approved
CetirizineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Cetirizine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Benzyl alcohol.Approved, Illicit, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Benzyl alcohol.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Benzyl alcohol.Approved, Investigational, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Benzyl alcohol.Approved
ChloroquineThe metabolism of Benzyl alcohol can be decreased when combined with Chloroquine.Approved, Vet Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Chlorphenamine.Approved
ChlorpromazineThe metabolism of Benzyl alcohol can be decreased when combined with Chlorpromazine.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Benzyl alcohol.Approved, Investigational, Withdrawn
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Chlorzoxazone.Approved
CholecalciferolThe metabolism of Benzyl alcohol can be decreased when combined with Cholecalciferol.Approved, Nutraceutical
CimetidineThe metabolism of Benzyl alcohol can be decreased when combined with Cimetidine.Approved
CinacalcetThe metabolism of Benzyl alcohol can be decreased when combined with Cinacalcet.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Benzyl alcohol.Approved, Vet Approved
CitalopramThe metabolism of Benzyl alcohol can be decreased when combined with Citalopram.Approved
ClarithromycinThe metabolism of Benzyl alcohol can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Benzyl alcohol can be decreased when combined with Clemastine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Clidinium.Approved
ClobazamThe metabolism of Benzyl alcohol can be decreased when combined with Clobazam.Approved, Illicit
clomethiazoleThe risk or severity of adverse effects can be increased when clomethiazole is combined with Benzyl alcohol.Investigational
ClomipramineThe metabolism of Benzyl alcohol can be decreased when combined with Clomipramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Clonazepam.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Clonidine.Approved
ClopenthixolThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Clopenthixol.Experimental
ClopidogrelThe metabolism of Benzyl alcohol can be decreased when combined with Clopidogrel.Approved, Nutraceutical
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Benzyl alcohol.Approved, Illicit
ClothiapineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Clothiapine.Experimental
ClotrimazoleThe metabolism of Benzyl alcohol can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe metabolism of Benzyl alcohol can be decreased when combined with Clozapine.Approved
CobicistatThe serum concentration of Benzyl alcohol can be increased when it is combined with Cobicistat.Approved
CocaineThe metabolism of Benzyl alcohol can be decreased when combined with Cocaine.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Benzyl alcohol.Approved, Illicit
ConivaptanThe serum concentration of Benzyl alcohol can be increased when it is combined with Conivaptan.Approved, Investigational
CrisaboroleThe metabolism of Benzyl alcohol can be decreased when combined with Crisaborole.Approved
CrizotinibThe metabolism of Benzyl alcohol can be decreased when combined with Crizotinib.Approved
CyclizineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Cyclizine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Benzyl alcohol.Approved
CyclosporineThe metabolism of Benzyl alcohol can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Cyproheptadine.Approved
Cyproterone acetateThe serum concentration of Benzyl alcohol can be decreased when it is combined with Cyproterone acetate.Approved, Investigational
DabrafenibThe serum concentration of Benzyl alcohol can be decreased when it is combined with Dabrafenib.Approved
DantroleneThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Dantrolene.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Benzyl alcohol.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Dapoxetine.Investigational
DarifenacinThe metabolism of Benzyl alcohol can be decreased when combined with Darifenacin.Approved, Investigational
DarunavirThe serum concentration of Benzyl alcohol can be increased when it is combined with Darunavir.Approved
DasatinibThe serum concentration of Benzyl alcohol can be increased when it is combined with Dasatinib.Approved, Investigational
DeferasiroxThe serum concentration of Benzyl alcohol can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Benzyl alcohol can be decreased when combined with Delavirdine.Approved
DeramciclaneThe risk or severity of adverse effects can be increased when Deramciclane is combined with Benzyl alcohol.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Benzyl alcohol.Approved
DesipramineThe metabolism of Benzyl alcohol can be decreased when combined with Desipramine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Desloratadine.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Detomidine.Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Dexbrompheniramine.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Benzyl alcohol.Approved, Vet Approved
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Benzyl alcohol.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Benzyl alcohol.Approved, Illicit, Investigational, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Benzyl alcohol.Approved, Investigational
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Benzyl alcohol.Approved, Illicit, Vet Approved
Diethyl etherThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Diethyl ether.Experimental
DifenoxinThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Difenoxin.Approved, Illicit
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Benzyl alcohol.Approved, Illicit
DihydroergotamineThe metabolism of Benzyl alcohol can be decreased when combined with Dihydroergotamine.Approved
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Benzyl alcohol.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Benzyl alcohol.Experimental, Illicit
DiltiazemThe metabolism of Benzyl alcohol can be decreased when combined with Diltiazem.Approved
DimenhydrinateThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Dimenhydrinate.Approved
DiphenhydramineThe metabolism of Benzyl alcohol can be decreased when combined with Diphenhydramine.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Benzyl alcohol.Approved, Illicit
DixyrazineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Dixyrazine.Experimental
DoramectinThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Doramectin.Vet Approved
DosulepinThe metabolism of Benzyl alcohol can be decreased when combined with Dosulepin.Approved
DoxepinThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Doxepin.Approved
DoxorubicinThe metabolism of Benzyl alcohol can be decreased when combined with Doxorubicin.Approved, Investigational
DoxycyclineThe metabolism of Benzyl alcohol can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Benzyl alcohol.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with DPDPE.Investigational
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Benzyl alcohol.Approved, Illicit
DronedaroneThe metabolism of Benzyl alcohol can be decreased when combined with Dronedarone.Approved
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Benzyl alcohol.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Benzyl alcohol.Experimental, Illicit
DuloxetineThe metabolism of Benzyl alcohol can be decreased when combined with Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Benzyl alcohol.Approved
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Benzyl alcohol.Experimental, Illicit
EcopipamThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Ecopipam.Investigational
EfavirenzThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Efavirenz.Approved, Investigational
EliglustatThe metabolism of Benzyl alcohol can be decreased when combined with Eliglustat.Approved
EltanoloneThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Eltanolone.Investigational
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Benzyl alcohol.Approved, Investigational, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Entacapone.Approved, Investigational
EnzalutamideThe serum concentration of Benzyl alcohol can be decreased when it is combined with Enzalutamide.Approved
ErythromycinThe metabolism of Benzyl alcohol can be decreased when combined with Erythromycin.Approved, Vet Approved
EscitalopramThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Escitalopram.Approved, Investigational
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Benzyl alcohol.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Benzyl alcohol.Approved
EthanolBenzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Benzyl alcohol.Approved, Illicit, Withdrawn
EthosuximideThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Ethosuximide.Approved
EthotoinThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Ethotoin.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Benzyl alcohol.Withdrawn
Ethyl chlorideThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Ethyl chloride.Experimental, Investigational
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Benzyl alcohol.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Benzyl alcohol.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Etidocaine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Etifoxine.Investigational, Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Etizolam.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Benzyl alcohol.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Etoperidone.Withdrawn
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Benzyl alcohol.Illicit, Vet Approved
EzogabineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Felbamate.Approved
FelodipineThe metabolism of Benzyl alcohol can be decreased when combined with Felodipine.Approved, Investigational
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Benzyl alcohol.Approved, Illicit, Withdrawn
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Benzyl alcohol.Approved, Illicit, Investigational, Vet Approved
FexofenadineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Fexofenadine.Approved
FlibanserinThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Flibanserin.Approved
FluanisoneThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Fluanisone.Experimental
FluconazoleThe metabolism of Benzyl alcohol can be decreased when combined with Fluconazole.Approved
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Benzyl alcohol.Approved, Illicit
FlunarizineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Benzyl alcohol.Approved, Illicit
FluoxetineThe metabolism of Benzyl alcohol can be decreased when combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Benzyl alcohol.Approved, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Benzyl alcohol.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Benzyl alcohol.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Fluspirilene is combined with Benzyl alcohol.Approved, Investigational
Fluticasone propionateThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Fluticasone propionate.Approved
FluvoxamineThe metabolism of Benzyl alcohol can be decreased when combined with Fluvoxamine.Approved, Investigational
FosamprenavirThe metabolism of Benzyl alcohol can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Benzyl alcohol can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe metabolism of Benzyl alcohol can be increased when combined with Fosphenytoin.Approved
FospropofolThe risk or severity of adverse effects can be increased when Fospropofol is combined with Benzyl alcohol.Approved, Illicit, Investigational
Fusidic AcidThe serum concentration of Benzyl alcohol can be increased when it is combined with Fusidic Acid.Approved
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Benzyl alcohol.Approved, Investigational
Gabapentin EnacarbilThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Gabapentin Enacarbil.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Benzyl alcohol.Approved, Illicit, Investigational
GepironeThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Benzyl alcohol.Approved, Illicit
GuanfacineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Benzyl alcohol.Approved, Illicit, Withdrawn
HaloperidolThe metabolism of Benzyl alcohol can be decreased when combined with Haloperidol.Approved
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Benzyl alcohol.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Benzyl alcohol.Approved, Illicit, Investigational
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Benzyl alcohol.Approved
HyaluronidaseThe risk or severity of adverse effects can be increased when Hyaluronidase is combined with Benzyl alcohol.Approved, Investigational
HydrocodoneBenzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Benzyl alcohol.Approved, Illicit
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Benzyl alcohol.Approved
IdelalisibThe serum concentration of Benzyl alcohol can be increased when it is combined with Idelalisib.Approved
IloperidoneThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Iloperidone.Approved
ImatinibThe metabolism of Benzyl alcohol can be decreased when combined with Imatinib.Approved
ImipramineThe metabolism of Benzyl alcohol can be decreased when combined with Imipramine.Approved
IndalpineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Indalpine.Investigational, Withdrawn
IndinavirThe metabolism of Benzyl alcohol can be decreased when combined with Indinavir.Approved
IndiplonThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Indiplon.Investigational
IrbesartanThe metabolism of Benzyl alcohol can be decreased when combined with Irbesartan.Approved, Investigational
IsavuconazoniumThe metabolism of Benzyl alcohol can be decreased when combined with Isavuconazonium.Approved, Investigational
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Benzyl alcohol.Approved, Vet Approved
IsoniazidThe metabolism of Benzyl alcohol can be decreased when combined with Isoniazid.Approved
IsradipineThe metabolism of Benzyl alcohol can be decreased when combined with Isradipine.Approved
ItraconazoleThe metabolism of Benzyl alcohol can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Benzyl alcohol can be increased when it is combined with Ivacaftor.Approved
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Benzyl alcohol.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Ketazolam is combined with Benzyl alcohol.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Ketobemidone is combined with Benzyl alcohol.Approved, Investigational
KetoconazoleThe metabolism of Benzyl alcohol can be decreased when combined with Ketoconazole.Approved, Investigational
LamotrigineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Lamotrigine.Approved, Investigational
LapatinibThe metabolism of Benzyl alcohol can be decreased when combined with Lapatinib.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Levetiracetam.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Benzyl alcohol.Approved, Investigational
LevocabastineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Levocetirizine.Approved
LevodopaThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Levodopa.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Benzyl alcohol.Approved, Investigational
LevomilnacipranThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Levomilnacipran.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Benzyl alcohol.Approved
LidocaineThe metabolism of Benzyl alcohol can be decreased when combined with Lidocaine.Approved, Vet Approved
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Benzyl alcohol.Approved
LobeglitazoneThe metabolism of Benzyl alcohol can be decreased when combined with Lobeglitazone.Approved, Investigational
LofentanilThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Lofentanil.Illicit
LopinavirThe metabolism of Benzyl alcohol can be decreased when combined with Lopinavir.Approved
LoprazolamThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Loprazolam.Experimental
LoratadineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Loratadine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Benzyl alcohol.Approved
LorcaserinThe metabolism of Benzyl alcohol can be decreased when combined with Lorcaserin.Approved
LormetazepamThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Lormetazepam.Approved
LosartanThe metabolism of Benzyl alcohol can be decreased when combined with Losartan.Approved
LovastatinThe metabolism of Benzyl alcohol can be decreased when combined with Lovastatin.Approved, Investigational
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Benzyl alcohol.Approved
LuliconazoleThe serum concentration of Benzyl alcohol can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Benzyl alcohol can be increased when it is combined with Lumacaftor.Approved
LumefantrineThe metabolism of Benzyl alcohol can be decreased when combined with Lumefantrine.Approved
LurasidoneThe risk or severity of adverse effects can be increased when Lurasidone is combined with Benzyl alcohol.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Benzyl alcohol.Approved, Vet Approved
ManidipineThe metabolism of Benzyl alcohol can be decreased when combined with Manidipine.Approved, Investigational
MaprotilineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Maprotiline.Approved
MebicarThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Mebicar.Experimental
MeclizineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Meclizine.Approved
MedazepamThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Medazepam.Experimental
MedetomidineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Medetomidine.Vet Approved
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Benzyl alcohol.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Melperone.Approved, Investigational
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Benzyl alcohol.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Benzyl alcohol.Approved, Illicit
MeptazinolThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Meptazinol.Experimental
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Benzyl alcohol.Approved, Investigational
MetaxaloneThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Metaxalone.Approved
MethadoneThe metabolism of Benzyl alcohol can be decreased when combined with Methadone.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Benzyl alcohol.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Methapyrilene is combined with Benzyl alcohol.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Benzyl alcohol.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Methocarbamol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Benzyl alcohol.Approved
MethotrimeprazineBenzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Benzyl alcohol.Approved, Investigational, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Methsuximide.Approved
MethylecgonineThe risk or severity of adverse effects can be increased when Methylecgonine is combined with Benzyl alcohol.Experimental
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Benzyl alcohol.Approved
MetoprololThe metabolism of Benzyl alcohol can be decreased when combined with Metoprolol.Approved, Investigational
MetyrosineBenzyl alcohol may increase the sedative activities of Metyrosine.Approved
MexiletineThe metabolism of Benzyl alcohol can be decreased when combined with Mexiletine.Approved
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Benzyl alcohol.Approved, Illicit
MidostaurinThe metabolism of Benzyl alcohol can be decreased when combined with Midostaurin.Approved
MifepristoneThe serum concentration of Benzyl alcohol can be increased when it is combined with Mifepristone.Approved, Investigational
MilnacipranThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Milnacipran.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Benzyl alcohol.Approved, Investigational
MirabegronThe metabolism of Benzyl alcohol can be decreased when combined with Mirabegron.Approved
MirtazapineBenzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MitotaneThe serum concentration of Benzyl alcohol can be decreased when it is combined with Mitotane.Approved
MolindoneThe risk or severity of adverse effects can be increased when Molindone is combined with Benzyl alcohol.Approved
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Benzyl alcohol.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Benzyl alcohol.Approved, Investigational
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Benzyl alcohol.Approved
NefazodoneThe metabolism of Benzyl alcohol can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Benzyl alcohol can be decreased when combined with Nelfinavir.Approved
NetupitantThe serum concentration of Benzyl alcohol can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Benzyl alcohol can be increased when combined with Nevirapine.Approved
NicardipineThe metabolism of Benzyl alcohol can be decreased when combined with Nicardipine.Approved
NicotineThe metabolism of Benzyl alcohol can be decreased when combined with Nicotine.Approved
NilotinibThe metabolism of Benzyl alcohol can be decreased when combined with Nilotinib.Approved, Investigational
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Benzyl alcohol.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Benzyl alcohol.Approved, Vet Approved
NorfluraneThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Norflurane.Investigational
NormethadoneThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Normethadone.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Nortriptyline.Approved
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Benzyl alcohol.Approved, Investigational
OlaparibThe metabolism of Benzyl alcohol can be decreased when combined with Olaparib.Approved
OlopatadineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Olopatadine.Approved
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Benzyl alcohol.Approved
OpiumThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Opium.Approved, Illicit
OrphenadrineBenzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Osanetant is combined with Benzyl alcohol.Investigational
OsimertinibThe serum concentration of Benzyl alcohol can be increased when it is combined with Osimertinib.Approved
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Benzyl alcohol.Approved
OxethazaineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Oxethazaine.Approved, Investigational
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Benzyl alcohol.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Benzyl alcohol.Approved
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Benzyl alcohol.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Benzyl alcohol.Approved, Investigational, Vet Approved
PalbociclibThe serum concentration of Benzyl alcohol can be increased when it is combined with Palbociclib.Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Benzyl alcohol.Approved
PanobinostatThe serum concentration of Benzyl alcohol can be increased when it is combined with Panobinostat.Approved, Investigational
ParaldehydeBenzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
ParoxetineThe metabolism of Benzyl alcohol can be decreased when combined with Paroxetine.Approved, Investigational
Peginterferon alfa-2bThe serum concentration of Benzyl alcohol can be decreased when it is combined with Peginterferon alfa-2b.Approved
PenfluridolThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Penfluridol.Experimental
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Benzyl alcohol.Approved, Vet Approved
PentobarbitalThe metabolism of Benzyl alcohol can be increased when combined with Pentobarbital.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Benzyl alcohol.Approved
PerazineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Perazine.Investigational
PerospironeThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Perospirone.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Benzyl alcohol.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Benzyl alcohol.Approved
PhenazocineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Phenazocine.Experimental
PhenibutThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Phenibut.Experimental
PhenobarbitalThe metabolism of Benzyl alcohol can be increased when combined with Phenobarbital.Approved
PhenoperidineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Phenoperidine.Experimental
PhenoxyethanolThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Phenoxyethanol.Approved
PhenytoinThe metabolism of Benzyl alcohol can be increased when combined with Phenytoin.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Benzyl alcohol.Approved
PioglitazoneThe metabolism of Benzyl alcohol can be decreased when combined with Pioglitazone.Approved, Investigational
PipamperoneThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Pipamperone.Approved, Investigational
PipotiazineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Pipotiazine.Approved, Investigational
PiritramideThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Piritramide.Investigational
PizotifenThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Pizotifen.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Pomalidomide.Approved
PosaconazoleThe metabolism of Benzyl alcohol can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PramipexoleBenzyl alcohol may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Pramocaine.Approved
PrazepamThe risk or severity of adverse effects can be increased when Prazepam is combined with Benzyl alcohol.Approved, Illicit
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Benzyl alcohol.Approved, Illicit, Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Benzyl alcohol.Approved
PrimidoneThe metabolism of Benzyl alcohol can be increased when combined with Primidone.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Benzyl alcohol.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Benzyl alcohol.Approved, Vet Approved
PromazineThe metabolism of Benzyl alcohol can be decreased when combined with Promazine.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Promethazine.Approved
PropanididThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Propanidid.Experimental
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Benzyl alcohol.Approved, Vet Approved
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Benzyl alcohol.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Propoxycaine.Approved
ProtriptylineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Protriptyline.Approved
ProxibarbalThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Proxibarbal.Experimental
PSD502The risk or severity of adverse effects can be increased when PSD502 is combined with Benzyl alcohol.Investigational
QuazepamThe serum concentration of Benzyl alcohol can be increased when it is combined with Quazepam.Approved, Illicit
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Benzyl alcohol.Approved
QuinidineThe metabolism of Benzyl alcohol can be decreased when combined with Quinidine.Approved
QuinineThe metabolism of Benzyl alcohol can be decreased when combined with Quinine.Approved
QuinisocaineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Quinisocaine.Experimental
RabeprazoleThe metabolism of Benzyl alcohol can be decreased when combined with Rabeprazole.Approved, Investigational
RacloprideThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Ramelteon.Approved, Investigational
RanolazineThe metabolism of Benzyl alcohol can be decreased when combined with Ranolazine.Approved, Investigational
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Benzyl alcohol.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Benzyl alcohol.Approved, Withdrawn
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Benzyl alcohol.Approved, Investigational
RifabutinThe metabolism of Benzyl alcohol can be increased when combined with Rifabutin.Approved
RifampicinThe metabolism of Benzyl alcohol can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Benzyl alcohol can be increased when combined with Rifapentine.Approved
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Benzyl alcohol.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Ritanserin.Investigational
RitonavirThe metabolism of Benzyl alcohol can be decreased when combined with Ritonavir.Approved, Investigational
RolapitantThe metabolism of Benzyl alcohol can be decreased when combined with Rolapitant.Approved
RomifidineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Romifidine.Vet Approved
RopiniroleBenzyl alcohol may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Benzyl alcohol.Approved
RosiglitazoneThe metabolism of Benzyl alcohol can be decreased when combined with Rosiglitazone.Approved, Investigational
RotigotineBenzyl alcohol may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Benzyl alcohol.Approved
SaquinavirThe metabolism of Benzyl alcohol can be decreased when combined with Saquinavir.Approved, Investigational
ScopolamineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Scopolamine.Approved
SecobarbitalThe metabolism of Benzyl alcohol can be increased when combined with Secobarbital.Approved, Vet Approved
SepranoloneThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Sepranolone.Investigational
SertindoleThe risk or severity of adverse effects can be increased when Sertindole is combined with Benzyl alcohol.Approved, Investigational, Withdrawn
SertralineThe metabolism of Benzyl alcohol can be decreased when combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Benzyl alcohol.Approved, Vet Approved
SildenafilThe metabolism of Benzyl alcohol can be decreased when combined with Sildenafil.Approved, Investigational
SiltuximabThe serum concentration of Benzyl alcohol can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Benzyl alcohol can be increased when it is combined with Simeprevir.Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Benzyl alcohol.Approved
SorafenibThe metabolism of Benzyl alcohol can be decreased when combined with Sorafenib.Approved, Investigational
St. John's WortThe serum concentration of Benzyl alcohol can be decreased when it is combined with St. John's Wort.Investigational, Nutraceutical
StiripentolThe serum concentration of Benzyl alcohol can be increased when it is combined with Stiripentol.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Benzyl alcohol.Approved, Investigational
SulfamethoxazoleThe metabolism of Benzyl alcohol can be decreased when combined with Sulfamethoxazole.Approved
SulfisoxazoleThe metabolism of Benzyl alcohol can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Benzyl alcohol.Approved, Investigational
SultoprideThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Sultopride.Experimental
SuvorexantBenzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TamoxifenThe metabolism of Benzyl alcohol can be decreased when combined with Tamoxifen.Approved
TandospironeThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Benzyl alcohol.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Tasimelteon.Approved
Technetium Tc-99m tilmanoceptBenzyl alcohol may decrease effectiveness of Technetium Tc-99m tilmanocept as a diagnostic agent.Approved, Investigational
TelaprevirThe metabolism of Benzyl alcohol can be decreased when combined with Telaprevir.Approved, Withdrawn
TelithromycinThe metabolism of Benzyl alcohol can be decreased when combined with Telithromycin.Approved
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Benzyl alcohol.Approved
Tenofovir disoproxilThe metabolism of Benzyl alcohol can be decreased when combined with Tenofovir disoproxil.Approved, Investigational
TerbinafineThe metabolism of Benzyl alcohol can be decreased when combined with Terbinafine.Approved, Investigational, Vet Approved
TeriflunomideThe serum concentration of Benzyl alcohol can be decreased when it is combined with Teriflunomide.Approved
TetrabenazineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Tetracaine.Approved, Vet Approved
TetrahydropalmatineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Tetrahydropalmatine.Investigational
TetrodotoxinThe risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Benzyl alcohol.Investigational
ThalidomideBenzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
TheophyllineThe metabolism of Benzyl alcohol can be decreased when combined with Theophylline.Approved
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Benzyl alcohol.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Benzyl alcohol.Approved, Vet Approved
ThioridazineThe metabolism of Benzyl alcohol can be decreased when combined with Thioridazine.Approved, Withdrawn
ThiotepaThe metabolism of Benzyl alcohol can be decreased when combined with Thiotepa.Approved
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Benzyl alcohol.Approved
TiagabineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Tiagabine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Tiapride.Approved, Investigational
TiclopidineThe metabolism of Benzyl alcohol can be decreased when combined with Ticlopidine.Approved
TiletamineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Tiletamine.Vet Approved
TilidineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Tilidine.Experimental
TipranavirThe metabolism of Benzyl alcohol can be decreased when combined with Tipranavir.Approved, Investigational
TizanidineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Tizanidine.Approved
TocilizumabThe serum concentration of Benzyl alcohol can be decreased when it is combined with Tocilizumab.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Tolcapone.Approved, Withdrawn
TopiramateThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Topiramate.Approved
TopiroxostatThe metabolism of Benzyl alcohol can be decreased when combined with Topiroxostat.Approved, Investigational
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Benzyl alcohol.Approved, Investigational
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Trans-2-Phenylcyclopropylamine is combined with Benzyl alcohol.Experimental
TranylcypromineThe metabolism of Benzyl alcohol can be decreased when combined with Tranylcypromine.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Benzyl alcohol.Approved, Investigational
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Benzyl alcohol.Approved
Tricaine methanesulfonateThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Tricaine methanesulfonate.Vet Approved
TrichloroethyleneThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Trichloroethylene.Experimental
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Benzyl alcohol.Approved
TrifluperidolThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Trifluperidol.Experimental
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Benzyl alcohol.Approved, Vet Approved
TrimethoprimThe metabolism of Benzyl alcohol can be decreased when combined with Trimethoprim.Approved, Vet Approved
TrimipramineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Triprolidine.Approved
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Benzyl alcohol.Approved, Investigational
VemurafenibThe serum concentration of Benzyl alcohol can be increased when it is combined with Vemurafenib.Approved
VenlafaxineThe metabolism of Benzyl alcohol can be decreased when combined with Venlafaxine.Approved
VeraliprideThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Veralipride.Experimental
VerapamilThe metabolism of Benzyl alcohol can be decreased when combined with Verapamil.Approved
VigabatrinThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Vigabatrin.Approved
Vinyl etherThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Vinyl ether.Experimental
VoriconazoleThe metabolism of Benzyl alcohol can be decreased when combined with Voriconazole.Approved, Investigational
VortioxetineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Vortioxetine.Approved
XenonThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Xenon.Experimental
XylazineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Xylazine.Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Benzyl alcohol.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Ziconotide.Approved
ZimelidineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Zimelidine.Withdrawn
ZiprasidoneThe metabolism of Benzyl alcohol can be decreased when combined with Ziprasidone.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Zolazepam.Vet Approved
ZolpidemBenzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Benzyl alcohol.Approved
ZotepineThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Zotepine.Approved, Investigational
ZucapsaicinThe metabolism of Benzyl alcohol can be decreased when combined with Zucapsaicin.Approved
ZuclopenthixolThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Benzyl alcohol.Approved, Investigational
Food Interactions
Not Available

References

Synthesis Reference

Cornelis Jongsma, Leon H. B. Frijns, Paula A. M. Raven-Donners, "Method for the preparation of a pure alkali metal benzoate and benzyl alcohol." U.S. Patent US4296245, issued June, 1940.

US4296245
General References
  1. Taylor PM, Chengelis CP, Miller WR, Parker GA, Gleason TR, Cozzi E: Evaluation of propofol containing 2% benzyl alcohol preservative in cats. J Feline Med Surg. 2012 Aug;14(8):516-26. doi: 10.1177/1098612X12440354. Epub 2012 Feb 24. [PubMed:22366290]
  2. Novak E, Stubbs SS, Sanborn EC, Eustice RM: The tolerance and safety of intravenously administered benzyl alcohol in methylprednisolone sodium succinate formulations in normal human subjects. Toxicol Appl Pharmacol. 1972 Sep;23(1):54-61. [PubMed:4560999]
  3. Meinking TL, Villar ME, Vicaria M, Eyerdam DH, Paquet D, Mertz-Rivera K, Rivera HF, Hiriart J, Reyna S: The clinical trials supporting benzyl alcohol lotion 5% (Ulesfia): a safe and effective topical treatment for head lice (pediculosis humanus capitis). Pediatr Dermatol. 2010 Jan-Feb;27(1):19-24. doi: 10.1111/j.1525-1470.2009.01059.x. [PubMed:20199404]
External Links
Human Metabolome Database
HMDB03119
KEGG Drug
D00077
KEGG Compound
C03485
PubChem Compound
244
PubChem Substance
175427090
ChemSpider
13860335
ChEBI
17987
ChEMBL
CHEMBL720
PharmGKB
PA448594
HET
010
RxList
RxList Drug Page
Wikipedia
Benzyl_alcohol
ATC Codes
P03AX06 — Benzyl alcohol
PDB Entries
2amq / 2hob / 2q6f / 3d23 / 3iwm / 4ii8 / 5eb5 / 5eu8 / 5gwy / 5gwz
FDA label
Download (1.05 MB)
MSDS
Download (50.6 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedTreatmentOtitis Externa1
3CompletedTreatmentLice of the head1
4RecruitingTreatmentHip Pain1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
CreamTopical10 mg/g
GelTopical2.5 %
LotionDental25 mg
GelDental25 mg
SuspensionAuricular (otic)
GelBuccal; Topical
OintmentTopical
GelTopical
CreamTopical
SprayTopical
Aerosol, sprayTopical
GelTopical100 mg/g
CreamPercutaneous; Topical; Transdermal
LiquidPercutaneous; Topical; Transdermal
LiquidTopical
LotionTopical50 mg/g
GelTopical.1 g/g
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5858383No1997-08-112017-08-11Us
US6139859No1997-08-112017-08-11Us
US6793931No2002-07-112022-07-11Us
US7294342No2004-05-192024-05-19Us

Properties

State
Liquid
Experimental Properties
PropertyValueSource
melting point (°C)-15..2 °C, 258 K, 5 °F# http://sitem.herts.ac.uk/aeru/footprint/en/Reports/953.htm.
boiling point (°C)205.3 °C, 478 K, 402 °F# http://sitem.herts.ac.uk/aeru/footprint/en/Reports/953.htm.
water solubility33 mg/mL, clear, colorless# http://www.chemicalbook.com/ProductChemicalPropertiesCB3852587_EN.htm
logP1.1# http://sitem.herts.ac.uk/aeru/footprint/en/Reports/953.htm.
pKa15.4# http://sitem.herts.ac.uk/aeru/footprint/en/Reports/953.htm.
Predicted Properties
PropertyValueSource
Water Solubility26.8 mg/mLALOGPS
logP1.07ALOGPS
logP1.21ChemAxon
logS-0.61ALOGPS
pKa (Strongest Acidic)15.02ChemAxon
pKa (Strongest Basic)-2.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area20.23 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity32.87 m3·mol-1ChemAxon
Polarizability11.89 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9906
Blood Brain Barrier+0.9698
Caco-2 permeable+0.8859
P-glycoprotein substrateNon-substrate0.8373
P-glycoprotein inhibitor INon-inhibitor0.9803
P-glycoprotein inhibitor IINon-inhibitor0.9629
Renal organic cation transporterNon-inhibitor0.8259
CYP450 2C9 substrateNon-substrate0.7995
CYP450 2D6 substrateNon-substrate0.9234
CYP450 3A4 substrateNon-substrate0.8408
CYP450 1A2 substrateInhibitor0.5434
CYP450 2C9 inhibitorNon-inhibitor0.9285
CYP450 2D6 inhibitorNon-inhibitor0.9623
CYP450 2C19 inhibitorNon-inhibitor0.7859
CYP450 3A4 inhibitorNon-inhibitor0.9558
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8458
Ames testNon AMES toxic0.9645
CarcinogenicityNon-carcinogens0.5381
BiodegradationReady biodegradable0.8774
Rat acute toxicity1.9753 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8998
hERG inhibition (predictor II)Non-inhibitor0.9625
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Download (7.19 KB)
Spectra
SpectrumSpectrum TypeSplash Key
GC-MS Spectrum - GC-MS (1 TMS)GC-MSsplash10-00ko-6900000000-a9d668ecd37a1579a6fe
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
GC-MS Spectrum - EI-BGC-MSsplash10-056r-9400000000-77cec715500da9c57a84
GC-MS Spectrum - EI-BGC-MSsplash10-056r-9400000000-8dc38068387df3fa06aa
GC-MS Spectrum - EI-BGC-MSsplash10-056r-9300000000-fb124b56257906cce9f1
GC-MS Spectrum - EI-BGC-MSsplash10-056r-9400000000-7a77e67486ae3b2dd855
GC-MS Spectrum - EI-BGC-MSsplash10-056r-9400000000-dd0878988e7c2d9a5431
GC-MS Spectrum - GC-MSGC-MSsplash10-00ko-6900000000-a9d668ecd37a1579a6fe
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-0006-8900000000-c256b0b7a0755f08ac64
Mass Spectrum (Electron Ionization)MSsplash10-056r-9400000000-a8f1fd78fa3f8781f296
MS/MS Spectrum - Quattro_QQQ 10V, N/A (Annotated)LC-MS/MSsplash10-0a4i-9500000000-2a82c3dd7c6871f61c34
MS/MS Spectrum - Quattro_QQQ 25V, N/A (Annotated)LC-MS/MSsplash10-0006-9000000000-ad1762d5292c30b29bbd
MS/MS Spectrum - Quattro_QQQ 40V, N/ALC-MS/MSsplash10-0006-9000000000-3c8d4c630cf42e3bfd3f
MS/MS Spectrum - EI-B (HITACHI RMU-7M) , PositiveLC-MS/MSsplash10-056r-9400000000-c4dcb2148958f946cd01
MS/MS Spectrum - EI-B (HITACHI RMU-6M) , PositiveLC-MS/MSsplash10-056r-9400000000-e17e577dbe4546313a91
MS/MS Spectrum - EI-B (JEOL JMS-01-SG-2) , PositiveLC-MS/MSsplash10-056r-9300000000-fb124b56257906cce9f1
MS/MS Spectrum - EI-B (HITACHI M-80) , PositiveLC-MS/MSsplash10-056r-9400000000-47b3605316c57e02b84f
MS/MS Spectrum - EI-B (HITACHI M-80B) , PositiveLC-MS/MSsplash10-056r-9400000000-dd0878988e7c2d9a5431
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0a4i-0900000000-3a71c23796a048eb999c
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0a4i-1900000000-40737e7bdf548d714249
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0uxr-9100000000-23e82914cfa9372ecafc
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0a4i-1900000000-17f95f5a398b5850abb2
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0a6r-7900000000-733d283e0916e755a736
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-9000000000-d0c6e5fc39516ee594b4
MS/MS Spectrum - , positiveLC-MS/MSsplash10-0a4i-3900000000-4d1bf15f6cf8f65bf0a6
1H NMR Spectrum1D NMRNot Applicable
1H NMR Spectrum1D NMRNot Applicable
13C NMR Spectrum1D NMRNot Applicable
1H NMR Spectrum1D NMRNot Applicable
13C NMR Spectrum1D NMRNot Applicable
[1H,13C] 2D NMR Spectrum2D NMRNot Applicable

Taxonomy

Description
This compound belongs to the class of organic compounds known as benzyl alcohols. These are organic compounds containing the phenylmethanol substructure.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Benzyl alcohols
Direct Parent
Benzyl alcohols
Alternative Parents
Primary alcohols / Hydrocarbon derivatives / Aromatic alcohols
Substituents
Benzyl alcohol / Organic oxygen compound / Hydrocarbon derivative / Aromatic alcohol / Primary alcohol / Organooxygen compound / Alcohol / Aromatic homomonocyclic compound
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
benzyl alcohols (CHEBI:17987) / an aromatic compound (BENZYL-ALCOHOL)

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C8
Uniprot ID
P10632
Uniprot Name
Cytochrome P450 2C8
Molecular Weight
55824.275 Da
References
  1. Nakajima T, Wang RS, Elovaara E, Gonzalez FJ, Gelboin HV, Raunio H, Pelkonen O, Vainio H, Aoyama T: Toluene metabolism by cDNA-expressed human hepatic cytochrome P450. Biochem Pharmacol. 1997 Feb 7;53(3):271-7. [PubMed:9065730]
  2. Kim H, Wang RS, Elovaara E, Raunio H, Pelkonen O, Aoyama T, Vainio H, Nakajima T: Cytochrome P450 isozymes responsible for the metabolism of toluene and styrene in human liver microsomes. Xenobiotica. 1997 Jul;27(7):657-65. [PubMed:9253143]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Vitamin d 24-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A1
Uniprot ID
P04798
Uniprot Name
Cytochrome P450 1A1
Molecular Weight
58164.815 Da
References
  1. Furman GM, Silverman DM, Schatz RA: Inhibition of rat lung mixed-function oxidase activity following repeated low-level toluene inhalation: possible role of toluene metabolites. J Toxicol Environ Health A. 1998 Aug 21;54(8):633-45. [PubMed:9726784]
  2. Nakajima T, Wang RS, Elovaara E, Gonzalez FJ, Gelboin HV, Raunio H, Pelkonen O, Vainio H, Aoyama T: Toluene metabolism by cDNA-expressed human hepatic cytochrome P450. Biochem Pharmacol. 1997 Feb 7;53(3):271-7. [PubMed:9065730]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Electron carrier activity
Specific Function
Not Available
Gene Name
ALDH2
Uniprot ID
P05091
Uniprot Name
Aldehyde dehydrogenase, mitochondrial
Molecular Weight
56380.93 Da
References
  1. Kawamoto T, Koga M, Murata K, Matsuda S, Kodama Y: Effects of ALDH2, CYP1A1, and CYP2E1 genetic polymorphisms and smoking and drinking habits on toluene metabolism in humans. Toxicol Appl Pharmacol. 1995 Aug;133(2):295-304. [PubMed:7645026]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2B6
Uniprot ID
P20813
Uniprot Name
Cytochrome P450 2B6
Molecular Weight
56277.81 Da
References
  1. Nakajima T, Wang RS, Elovaara E, Gonzalez FJ, Gelboin HV, Raunio H, Pelkonen O, Vainio H, Aoyama T: Toluene metabolism by cDNA-expressed human hepatic cytochrome P450. Biochem Pharmacol. 1997 Feb 7;53(3):271-7. [PubMed:9065730]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A2
Uniprot ID
P05177
Uniprot Name
Cytochrome P450 1A2
Molecular Weight
58293.76 Da
References
  1. Nakajima T, Wang RS, Elovaara E, Gonzalez FJ, Gelboin HV, Raunio H, Pelkonen O, Vainio H, Aoyama T: Toluene metabolism by cDNA-expressed human hepatic cytochrome P450. Biochem Pharmacol. 1997 Feb 7;53(3):271-7. [PubMed:9065730]
  2. Kim H, Wang RS, Elovaara E, Raunio H, Pelkonen O, Aoyama T, Vainio H, Nakajima T: Cytochrome P450 isozymes responsible for the metabolism of toluene and styrene in human liver microsomes. Xenobiotica. 1997 Jul;27(7):657-65. [PubMed:9253143]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic ...
Gene Name
CYP2E1
Uniprot ID
P05181
Uniprot Name
Cytochrome P450 2E1
Molecular Weight
56848.42 Da
References
  1. Nakajima T, Wang RS, Elovaara E, Gonzalez FJ, Gelboin HV, Raunio H, Pelkonen O, Vainio H, Aoyama T: Toluene metabolism by cDNA-expressed human hepatic cytochrome P450. Biochem Pharmacol. 1997 Feb 7;53(3):271-7. [PubMed:9065730]
  2. Lipscomb JC, Barton HA, Tornero-Velez R, Evans MV, Alcasey S, Snawder JE, Laskey J: The metabolic rate constants and specific activity of human and rat hepatic cytochrome P-450 2E1 toward toluene and chloroform. J Toxicol Environ Health A. 2004 Apr 9;67(7):537-53. [PubMed:15129551]
  3. Kim H, Wang RS, Elovaara E, Raunio H, Pelkonen O, Aoyama T, Vainio H, Nakajima T: Cytochrome P450 isozymes responsible for the metabolism of toluene and styrene in human liver microsomes. Xenobiotica. 1997 Jul;27(7):657-65. [PubMed:9253143]
  4. Wang RS, Nakajima T, Park SS, Gelboin HV, Murayama N: Monoclonal antibody-directed assessment of toluene induction of rat hepatic cytochrome P450 isozymes. Biochem Pharmacol. 1993 Aug 3;46(3):413-9. [PubMed:8347164]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...
Gene Name
CYP2D6
Uniprot ID
P10635
Uniprot Name
Cytochrome P450 2D6
Molecular Weight
55768.94 Da
References
  1. Obach RS: Mechanism of cytochrome P4503A4- and 2D6-catalyzed dehydrogenation of ezlopitant as probed with isotope effects using five deuterated analogs. Drug Metab Dispos. 2001 Dec;29(12):1599-607. [PubMed:11717179]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Obach RS: Mechanism of cytochrome P4503A4- and 2D6-catalyzed dehydrogenation of ezlopitant as probed with isotope effects using five deuterated analogs. Drug Metab Dispos. 2001 Dec;29(12):1599-607. [PubMed:11717179]

Drug created on September 14, 2010 10:21 / Updated on November 09, 2017 03:55