Neuromuscular Blocking Agents

Name
Neuromuscular Blocking Agents
Accession Number
DBCAT000511
Description

Drugs that interrupt transmission of nerve impulses at the skeletal neuromuscular junction. They can be of two types, competitive, stabilizing blockers (NEUROMUSCULAR NONDEPOLARIZING AGENTS) or noncompetitive, depolarizing agents (NEUROMUSCULAR DEPOLARIZING AGENTS). Both prevent acetylcholine from triggering the muscle contraction and they are used as anesthesia adjuvants, as relaxants during electroshock, in convulsive states, etc.

Drugs
DrugDrug Description
SuccinylcholineA depolarizing skeletal muscle relaxant used as an adjunct to anesthesia and for skeletal muscle relaxation during intubation, mechanical ventilation, and surgical procedures.
CisatracuriumA skeletal muscle relaxant used to facilitate tracheal intubation, muscle relaxation in surgery, or mechanical ventilation.
RocuroniumA vecuronium analog used to facilitate tracheal intubation and to relax skeletal muscles during surgery.
Atracurium besylateA non-depolarizing neuromuscular blocker used to facilitate endotracheal intubation and relax skeletal muscles during surgery.
PancuroniumA neuromuscular blocker used as an adjunct to general anesthesia to facilitate tracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
VecuroniumA nondepolarizing neuromuscular blocking agent used to relax muscles or as an adjunct in general anesthesia during surgical procedures.
Metocurine iodideFor use as an anesthesia adjunct to induce skeletal muscle relaxation and to reduce the intensity of muscle contractions in convulsive therapy.
Gallamine triethiodideA nondepolarizing nerve blocker used in addition to anesthesia to cause skeletal muscle relaxation.
DoxacuriumA nondepolarizing neuromuscular blocking agent used as an adjunct to general anesthesia to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgical procedures.
TubocurarineA neuromuscular blocker used for the diagnosis of and facilitation of intubation after induction of anesthesia during surgical procedures.
MivacuriumA short-acting non-depolarizing neuromuscular blocking agent used to induce anesthesia during intubation and promote skeletal muscle relaxation during surgery or mechanical ventilation.
DecamethoniumFor use as a skeletal muscle relaxant
MetocurineMetocurine is a muscle relaxant.
PipecuroniumA nondepolarizing neuromuscular blocking agent used to relax muscles during anesthesia and surgical procedures.
RapacuroniumA nondepolarizing neuromuscular blocking agent used as an adjunct to general anesthesia to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgical procedures.
NeosaxitoxinNeosaxitoxin is under investigation in clinical trial NCT01786655 (Safety Study of Long-Acting Local Anesthetic).
AtracuriumNot Annotated
GallamineNot Annotated
AlcuroniumA non-depolarizing skeletal muscle relaxant similar to tubocurarine. It is used as an anesthesia adjuvant.
PyrantelAn anthelmintic used to treat helminth infections.
Drugs & Drug Targets
DrugTargetType
SuccinylcholineMuscarinic acetylcholine receptor M1target
SuccinylcholineCholinesteraseenzyme
SuccinylcholineMuscarinic acetylcholine receptor M2target
SuccinylcholineMuscarinic acetylcholine receptor M3target
SuccinylcholineAlpha-7 nicotinic cholinergic receptor subunittarget
SuccinylcholineNeuronal acetylcholine receptor subunit alpha-10target
CisatracuriumNeuronal acetylcholine receptor subunit alpha-2target
RocuroniumNeuronal acetylcholine receptor subunit alpha-2target
RocuroniumMuscarinic acetylcholine receptor M2target
Rocuronium5-hydroxytryptamine receptor 3Atarget
RocuroniumSolute carrier family 22 member 1transporter
RocuroniumSolute carrier organic anion transporter family member 1A2transporter
Atracurium besylateNeuronal acetylcholine receptor subunit alpha-2target
PancuroniumNeuronal acetylcholine receptor subunit alpha-2target
PancuroniumCholinesteraseenzyme
PancuroniumMuscarinic acetylcholine receptor M2target
PancuroniumMuscarinic acetylcholine receptor M3target
PancuroniumSolute carrier family 22 member 1transporter
PancuroniumSolute carrier family 22 member 2transporter
VecuroniumP-glycoprotein 1transporter
VecuroniumNeuronal acetylcholine receptor subunit alpha-2target
Metocurine iodideNeuronal acetylcholine receptor subunit alpha-2target
Gallamine triethiodideNeuronal acetylcholine receptor subunit alpha-2target
Gallamine triethiodideMuscarinic acetylcholine receptor M2target
Gallamine triethiodideAcetylcholinesterasetarget
Gallamine triethiodideMuscarinic acetylcholine receptor M1target
Gallamine triethiodideMuscarinic acetylcholine receptor M5target
DoxacuriumNeuronal acetylcholine receptor subunit alpha-2target
DoxacuriumMuscarinic acetylcholine receptor M2target
DoxacuriumCholinesteraseenzyme
TubocurarineNeuronal acetylcholine receptor subunit alpha-2target
TubocurarineAcetylcholinesterasetarget
Tubocurarine5-hydroxytryptamine receptor 3Atarget
TubocurarineSolute carrier family 22 member 1transporter
TubocurarineSolute carrier family 22 member 2transporter
TubocurarineNeuronal acetylcholine receptor subunit alpha-7target
TubocurarineCholinesteraseenzyme
MivacuriumNeuronal acetylcholine receptor subunit alpha-2target
MivacuriumMuscarinic acetylcholine receptor M2target
MivacuriumMuscarinic acetylcholine receptor M3target
MivacuriumCholinesterasetarget
DecamethoniumNeuronal acetylcholine receptor subunit alpha-2target
DecamethoniumAcetylcholinesterasetarget
DecamethoniumCholinesteraseenzyme
DecamethoniumNeuronal acetylcholine receptor subunit alpha-4target
DecamethoniumNeuronal acetylcholine receptor subunit beta-2target
MetocurineNeuronal acetylcholine receptor subunit alpha-2target
MetocurineMuscarinic acetylcholine receptor M2target
PipecuroniumNeuronal acetylcholine receptor subunit alpha-2target
PipecuroniumMuscarinic acetylcholine receptor M2target
PipecuroniumMuscarinic acetylcholine receptor M3target
PipecuroniumCholinesteraseenzyme
RapacuroniumMuscarinic acetylcholine receptor M2target
PyrantelG-protein coupled receptor 35target
PyrantelCytochrome P450 4A11enzyme
PyrantelMuscarinic acetylcholine receptor M1target