Alcuronium

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Alcuronium
Accession Number
DB13648
Type
Small Molecule
Groups
Experimental
Description

A non-depolarizing skeletal muscle relaxant similar to tubocurarine. It is used as an anesthesia adjuvant.

Structure
Thumb
Synonyms
  • Alcuronum
  • Alloferine
  • Diallylnortoxiferine
  • Diallyltoxiferine
  • N,N'-diallyl-bis-nor-toxiferine
  • N,N'-Diallylnortoxiferinium
Product Ingredients
IngredientUNIICASInChI Key
Alcuronium chloride490DW6501Y15180-03-7CPYGBGOXCJJJGC-GKLGUMFISA-L
Categories
UNII
S8U3J5W06N
CAS number
23214-96-2
Weight
Average: 666.909
Monoisotopic: 666.392279706
Chemical Formula
C44H50N4O2
InChI Key
MUQUYTSLDVKIOF-CHJKCJHBSA-N
InChI
InChI=1S/C44H50N4O2/c1-3-17-47-19-15-43-35-9-5-7-11-37(35)45-26-34-32-24-40-44(16-20-48(40,18-4-2)28-30(32)14-22-50)36-10-6-8-12-38(36)46(42(34)44)25-33(41(43)45)31(23-39(43)47)29(27-47)13-21-49/h3-14,25-26,31-32,39-42,49-50H,1-2,15-24,27-28H2/q+2/b29-13-,30-14-,33-25-,34-26-/t31-,32-,39-,40-,41-,42-,43+,44+,47-,48-/m0/s1
IUPAC Name
(1S,9Z,11S,13S,14R,17S,25Z,27S,28E,30R,33S,35S,37E,38S)-28,37-bis(2-hydroxyethylidene)-14,30-bis(prop-2-en-1-yl)-8,14,24,30-tetraazaundecacyclo[25.5.2.2^{11,14}.1^{1,8}.1^{10,17}.0^{2,7}.0^{13,17}.0^{18,23}.0^{30,33}.0^{24,35}.0^{26,38}]octatriaconta-2(7),3,5,9,18(23),19,21,25-octaene-14,30-diium
SMILES
[H][C@@]12C[C@@]3([H])\C(C[N@+]1(CC=C)CC[C@@]21C2=C(C=CC=C2)N2\C=C4/[C@]5([H])N(\C=C3/[C@@]12[H])C1=C(C=CC=C1)[C@@]51CC[N@@+]2(CC=C)C\C(=C\CO)[C@]4([H])C[C@@]12[H])=C/CO

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
1,10-PhenanthrolineThe therapeutic efficacy of Alcuronium can be decreased when used in combination with 1,10-Phenanthroline.
AcetaminophenThe risk or severity of adverse effects can be increased when Alcuronium is combined with Acetaminophen.
AclidiniumAclidinium may increase the anticholinergic activities of Alcuronium.
AlaproclateThe risk or severity of adverse effects can be increased when Alcuronium is combined with Alaproclate.
Aluminum sulfateThe therapeutic efficacy of Aluminum sulfate can be decreased when used in combination with Alcuronium.
AmbenoniumThe therapeutic efficacy of Alcuronium can be decreased when used in combination with Ambenonium.
AmitriptylineAlcuronium may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
AmoxapineAlcuronium may increase the central nervous system depressant (CNS depressant) activities of Amoxapine.
Anisotropine methylbromideAnisotropine methylbromide may increase the anticholinergic activities of Alcuronium.
AprotininThe therapeutic efficacy of Alcuronium can be decreased when used in combination with Aprotinin.
Additional Data Available
  • Extended Description
    Extended Description

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  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

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  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

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  • Action
    Action

    An effect category for each drug interaction. Know how this interaction affects the subject drug.

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Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
10308750
ChEBI
55313
ChEMBL
CHEMBL3305985
Wikipedia
Alcuronium_chloride
ATC Codes
M03AA01 — Alcuronium

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.000244 mg/mLALOGPS
logP3.28ALOGPS
logP-4.3ChemAxon
logS-6.5ALOGPS
pKa (Strongest Acidic)15.3ChemAxon
pKa (Strongest Basic)1.52ChemAxon
Physiological Charge2ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area46.94 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity226.64 m3·mol-1ChemAxon
Polarizability75.98 Å3ChemAxon
Number of Rings11ChemAxon
Bioavailability1ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as strychnos alkaloids. These are alkaloids having a core structure based on the strychnan, stemmadenine (seco-curan), or the akuammicine (curan) skeleton.
Kingdom
Organic compounds
Super Class
Alkaloids and derivatives
Class
Strychnos alkaloids
Sub Class
Not Available
Direct Parent
Strychnos alkaloids
Alternative Parents
Curan alkaloids / Carbazoles / Indolizidines / Tertiary alkylarylamines / Aralkylamines / Piperidines / N-alkylpyrrolidines / Benzenoids / Tetraalkylammonium salts / Allylamines
show 7 more
Substituents
Strychnan skeleton / Akuammicine-skeleton / Curan skeleton / Stemmadenine-skeleton / Carbazole / Indole or derivatives / Indolizidine / Tertiary aliphatic/aromatic amine / Aralkylamine / Benzenoid
show 22 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
indole alkaloid (CHEBI:55313)

Drug created on June 23, 2017 14:45 / Updated on May 01, 2019 13:35