Alcuronium

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Alcuronium
Accession Number
DB13648
Description

A non-depolarizing skeletal muscle relaxant similar to tubocurarine. It is used as an anesthesia adjuvant.

Type
Small Molecule
Groups
Experimental
Structure
Thumb
Weight
Average: 666.909
Monoisotopic: 666.392279706
Chemical Formula
C44H50N4O2
Synonyms
  • Alcuronum
  • Alloferine
  • Diallylnortoxiferine
  • Diallyltoxiferine
  • N,N'-diallyl-bis-nor-toxiferine
  • N,N'-Diallylnortoxiferinium

Pharmacology

Indication
Not Available
Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
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Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
Learn about our commercial Adverse Effects data.
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Alcuronium.
AcetophenazineThe risk or severity of adverse effects can be increased when Acetophenazine is combined with Alcuronium.
AcetyldigitoxinThe risk or severity of Cardiac Arrhythmia can be increased when Alcuronium is combined with Acetyldigitoxin.
AclidiniumAlcuronium may increase the central nervous system depressant (CNS depressant) activities of Aclidinium.
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Alcuronium.
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Alcuronium.
AlimemazineThe risk or severity of adverse effects can be increased when Alimemazine is combined with Alcuronium.
AlloinThe therapeutic efficacy of Alloin can be decreased when used in combination with Alcuronium.
AlmotriptanThe risk or severity of adverse effects can be increased when Almotriptan is combined with Alcuronium.
AlosetronThe risk or severity of adverse effects can be increased when Alosetron is combined with Alcuronium.
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

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  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

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  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

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  • Action
    Action

    An effect category for each drug interaction. Know how this interaction affects the subject drug.

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Food Interactions
Not Available

Products

Product Ingredients
IngredientUNIICASInChI Key
Alcuronium chloride490DW6501Y15180-03-7CPYGBGOXCJJJGC-GKLGUMFISA-L

Categories

ATC Codes
M03AA01 — Alcuronium
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as strychnos alkaloids. These are alkaloids having a core structure based on the strychnan, stemmadenine (seco-curan), or the akuammicine (curan) skeleton.
Kingdom
Organic compounds
Super Class
Alkaloids and derivatives
Class
Strychnos alkaloids
Sub Class
Not Available
Direct Parent
Strychnos alkaloids
Alternative Parents
Curan alkaloids / Carbazoles / Indolizidines / Tertiary alkylarylamines / Aralkylamines / Piperidines / N-alkylpyrrolidines / Benzenoids / Tetraalkylammonium salts / Allylamines
show 7 more
Substituents
Akuammicine-skeleton / Alcohol / Allylamine / Amine / Aralkylamine / Aromatic heteropolycyclic compound / Azacycle / Benzenoid / Carbazole / Curan skeleton
show 22 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
indole alkaloid (CHEBI:55313)

Chemical Identifiers

UNII
S8U3J5W06N
CAS number
23214-96-2
InChI Key
MUQUYTSLDVKIOF-CHJKCJHBSA-N
InChI
InChI=1S/C44H50N4O2/c1-3-17-47-19-15-43-35-9-5-7-11-37(35)45-26-34-32-24-40-44(16-20-48(40,18-4-2)28-30(32)14-22-50)36-10-6-8-12-38(36)46(42(34)44)25-33(41(43)45)31(23-39(43)47)29(27-47)13-21-49/h3-14,25-26,31-32,39-42,49-50H,1-2,15-24,27-28H2/q+2/b29-13-,30-14-,33-25-,34-26-/t31-,32-,39-,40-,41-,42-,43+,44+,47-,48-/m0/s1
IUPAC Name
(1S,9Z,11S,13S,14R,17S,25Z,27S,28E,30R,33S,35S,37E,38S)-28,37-bis(2-hydroxyethylidene)-14,30-bis(prop-2-en-1-yl)-8,14,24,30-tetraazaundecacyclo[25.5.2.2^{11,14}.1^{1,8}.1^{10,17}.0^{2,7}.0^{13,17}.0^{18,23}.0^{30,33}.0^{24,35}.0^{26,38}]octatriaconta-2(7),3,5,9,18(23),19,21,25-octaene-14,30-diium
SMILES
[H][C@@]12C[C@@]3([H])\C(C[N@+]1(CC=C)CC[C@@]21C2=C(C=CC=C2)N2\C=C4/[C@]5([H])N(\C=C3/[C@@]12[H])C1=C(C=CC=C1)[C@@]51CC[N@@+]2(CC=C)C\C(=C\CO)[C@]4([H])C[C@@]12[H])=C/CO

References

General References
Not Available
ChemSpider
10308750
RxNav
460
ChEBI
55313
ChEMBL
CHEMBL3305985
Wikipedia
Alcuronium_chloride

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.000244 mg/mLALOGPS
logP3.28ALOGPS
logP-4.3ChemAxon
logS-6.5ALOGPS
pKa (Strongest Acidic)15.3ChemAxon
pKa (Strongest Basic)1.52ChemAxon
Physiological Charge2ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area46.94 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity226.64 m3·mol-1ChemAxon
Polarizability75.98 Å3ChemAxon
Number of Rings11ChemAxon
Bioavailability1ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on June 23, 2017 14:45 / Updated on June 12, 2020 10:53

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