Botulinum Toxin Type A


Botulinum Toxin Type A
Accession Number
DB00083  (BTD00092, BIOD00092)
Approved, Investigational
Biologic Classification
Protein Based Therapies
Other protein based therapies

Purified botulinum toxin from Clostridium botulinum, purified from culture via dialysis and acid precipitation.

Protein structure
Protein chemical formula
Protein average weight
149322.7 Da
>Botulinum Toxin Type A Sequence
Download FASTA Format
  • AbobotulinumtoxinA
  • BoNT/A
  • Bontoxilysin A
  • Botulinum neurotoxin type A precursor
  • BTX-A
  • IncobotulinumtoxinA
  • OnabotulinumtoxinA
  • Toxina botulĂ­nica A
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
BotoxPowder, for solution100 unitIntramuscularAllergan1992-12-31Not applicableCanada
BotoxInjection, powder, lyophilized, for solution200 [USP'U]/1Intradermal; IntramuscularAllergan, Inc.2010-01-11Not applicableUs
BotoxInjection, powder, lyophilized, for solution100 [USP'U]/1Intradermal; IntramuscularAllergan, Inc.1989-12-15Not applicableUs
BOTOX CosmeticInjection, powder, lyophilized, for solution100 [USP'U]/1IntramuscularAllergan2008-05-20Not applicableUs
BOTOX CosmeticInjection, powder, lyophilized, for solution50 [USP'U]/1IntramuscularAllergan2008-07-15Not applicableUs
BOTOX CosmeticPowder, for solution100 unitIntramuscularAllergan2001-05-07Not applicableCanada
DysportInjection, powder, lyophilized, for solution300 U/1IntramuscularIpsen Biopharmaceuticals, Inc.2009-11-02Not applicableUs
DysportInjection, powder, lyophilized, for solution300 [USP'U]/1IntramuscularMedicis Pharmaceutical Corporation2009-05-252015-03-31Us
DysportInjection, powder, lyophilized, for solution500 U/1IntramuscularIpsen Biopharmaceuticals, Inc.2009-11-02Not applicableUs
DysportInjection, powder, lyophilized, for solution300 U/1IntramuscularGalderma2009-11-02Not applicableUs
CAS number



For the treatment of cervical dystonia in adults to decrease the severity of abnormal head position and neck pain associated with cervical dystonia. Also for the treatment of severe primary axillary hyperhidrosis that is inadequately managed with topical agents and for the treatment of strabismus and blepharospasm associated with dystonia, including benign essential blepharospasm or VII nerve disorders in patients 12 years of age and above. Also used cosmetically to temporarily improve the appearance of moderate-to-severe frown lines between the eyebrows (glabellar lines) as well as for the treatment of excessive underarm sweating.

Associated Conditions
Associated Therapies

A 150 kDa neurotoxic protein produced from fermentation of Hall strain Clostridium botulinum type A grown in a medium containing casein hydrolysate, glucose and yeast extract. It is purified from the culture solution by dialysis and a series of acid precipitations to a complex consisting of the neurotoxin, and several accessory proteins. Botulinum Toxin Type A is not expected to be present in the peripheral blood at measurable levels following IM or intradermal injection at the recommended doses. The recommended quantities of neurotoxin administered at each treatment session are not expected to result in systemic, overt distant clinical effects, i.e. muscle weakness, in patients without other neuromuscular dysfunction. However, sub-clinical systemic effects have been shown by single-fiber electromyography after IM doses of botulinum toxins appropriate to produce clinically observable local muscle weakness.

Mechanism of action

Botulinum Toxin Type A blocks neuromuscular transmission by binding to acceptor sites on motor or sympathetic nerve terminals, entering the nerve terminals, and inhibiting the release of acetylcholine. This inhibition occurs as the neurotoxin cleaves SNAP-25, a protein integral to the successful docking and release of acetylcholine from vesicles situated within nerve endings.

ASynaptosomal-associated protein 25
URho-related GTP-binding protein RhoBNot AvailableHuman

The chemical complexity of Botulinum Toxin Type A combined with its extreme potency limits the opportunity to study its pharmacokinetic profile in humans. Therefore, no human pharmacokinetic studies have been performed. Botulinum Toxin Type A is injected directly into the target organ, a skeletal muscle. Thus, bioavailability of the intravenous or oral route is not of clinical relevance.

Volume of distribution
Not Available
Protein binding
Not Available
Not Available
Route of elimination
Not Available
Half life
Not Available
Not Available

Based on toxicological studies, it has been estimated that the human LD50 by injection is approximately 2800 Units, equivalent to 28 individual vials of BOTOX (Botulinum Toxin Type A) Purified Neurotoxin Complex (100 Units) for a 70 kg adult. When injected intramuscularly, Botulinum Toxin Type A has been shown to be teratogenic or to have embryocidal effects in some animal species.

Affected organisms
  • Humans and other mammals
Not Available
Pharmacogenomic Effects/ADRs
Not Available


Drug Interactions
2,5-Dimethoxy-4-ethylthioamphetamineThe risk or severity of adverse effects can be increased when Botulinum Toxin Type A is combined with 2,5-Dimethoxy-4-ethylthioamphetamine.
3,4-MethylenedioxyamphetamineThe risk or severity of adverse effects can be increased when Botulinum Toxin Type A is combined with 3,4-Methylenedioxyamphetamine.
4-Bromo-2,5-dimethoxyamphetamineThe risk or severity of adverse effects can be increased when Botulinum Toxin Type A is combined with 4-Bromo-2,5-dimethoxyamphetamine.
4-MethoxyamphetamineThe risk or severity of adverse effects can be increased when Botulinum Toxin Type A is combined with 4-Methoxyamphetamine.
5-methoxy-N,N-dimethyltryptamineThe risk or severity of adverse effects can be increased when Botulinum Toxin Type A is combined with 5-methoxy-N,N-dimethyltryptamine.
7-NitroindazoleThe risk or severity of adverse effects can be increased when Botulinum Toxin Type A is combined with 7-Nitroindazole.
AcepromazineThe risk or severity of adverse effects can be increased when Botulinum Toxin Type A is combined with Acepromazine.
AceprometazineThe risk or severity of adverse effects can be increased when Botulinum Toxin Type A is combined with Aceprometazine.
AcetazolamideThe risk or severity of adverse effects can be increased when Botulinum Toxin Type A is combined with Acetazolamide.
AcetophenazineThe risk or severity of adverse effects can be increased when Botulinum Toxin Type A is combined with Acetophenazine.
Food Interactions
Not Available


General References
  1. Montecucco C, Molgo J: Botulinal neurotoxins: revival of an old killer. Curr Opin Pharmacol. 2005 Jun;5(3):274-9. [PubMed:15907915]
  2. Brin MF, Lew MF, Adler CH, Comella CL, Factor SA, Jankovic J, O'Brien C, Murray JJ, Wallace JD, Willmer-Hulme A, Koller M: Safety and efficacy of NeuroBloc (botulinum toxin type B) in type A-resistant cervical dystonia. Neurology. 1999 Oct 22;53(7):1431-8. [PubMed:10534247]
  3. Shukla HD, Sharma SK: Clostridium botulinum: a bug with beauty and weapon. Crit Rev Microbiol. 2005;31(1):11-8. [PubMed:15839401]
  4. Eisenach JH, Atkinson JL, Fealey RD: Hyperhidrosis: evolving therapies for a well-established phenomenon. Mayo Clin Proc. 2005 May;80(5):657-66. [PubMed:15887434]
  5. Schurch B, Corcos J: Botulinum toxin injections for paediatric incontinence. Curr Opin Urol. 2005 Jul;15(4):264-7. [PubMed:15928517]
External Links
KEGG Compound
PubChem Substance
Therapeutic Targets Database
RxList Drug Page
ATC Codes
M03AX01 — Botulinum toxin
AHFS Codes
  • 92:92.00 — Other Miscellaneous Therapeutic Agents
FDA label
Download (115 KB)

Clinical Trials

Clinical Trials
0CompletedTreatmentBladder Pain Syndrome1
0Not Yet RecruitingTreatmentGummy Smile Due to Hypermobile Upper Lip1
0RecruitingTreatmentComplex Regional Pain Syndrome (CRPS)1
0RecruitingTreatmentSecondary Headache Disorder1
0TerminatedTreatmentNeurocostal neuralgia1
0WithdrawnDiagnosticBenign Prostatic Hyperplasia (BPH) / Enlarged Prostate With Lower Urinary Tract Symptoms (LUTS) / Prostate Cancer1
1Active Not RecruitingTreatmentPruritus1
1CompletedOtherPsoriasis Vulgaris (Plaque Psoriasis)1
1CompletedTreatmentBMI >30 kg/m22
1CompletedTreatmentCerebral Palsy (CP) / Spasticity1
1CompletedTreatmentDry Eye Syndromes1
1CompletedTreatmentKnee Osteoarthritis (Knee OA)1
1CompletedTreatmentScrotal Pain1
1CompletedTreatmentVasculogenic Erectile Dysfunction1
1CompletedTreatmentWound; Abdomen, Abdominal Wall1
1Not Yet RecruitingTreatmentHyperhidrosis1
1Not Yet RecruitingTreatmentParkinson's Disease (PD)1
1RecruitingBasic ScienceHealthy Volunteers2
1RecruitingTreatmentAnhidrotic Area / Hyperhidrosis1
1RecruitingTreatmentBack Pain Lower Back / Cervical Pain1
1RecruitingTreatmentBotulinum Toxins, Type A / Plantar Fascitis1
1RecruitingTreatmentDepression / Parkinson's Disease (PD)1
1RecruitingTreatmentMyofascial Pain Syndromes / Myofascial Trigger Point Pain / Trigger Point Pain, Myofascial1
1RecruitingTreatmentUrinary Bladder, Overactive1
1Unknown StatusTreatmentThoracic Outlet Syndrome1
1WithdrawnTreatmentBruxism / Myofascial Pain Dysfunction Syndrome, Temporomandibular Joint / Temporomandibular Joint Disorders / Temporomandibular Joint Dysfunction Syndrome1
1, 2Active Not RecruitingPreventionNonvalvular Atrial Fibrillation1
1, 2CompletedTreatmentBenign Prostatic Hyperplasia (BPH)1
1, 2CompletedTreatmentCervical Dystonia / Refractory Cervicothoracic Myofascial Pain Syndrome (CMPS)1
1, 2CompletedTreatmentCluster Headache1
1, 2CompletedTreatmentDetrusor Hyperreflexia / Detrusor Instability / Urinary Bladder, Overactive1
1, 2CompletedTreatmentHeadache Disorders / Trigeminal Neuralgia (TN)1
1, 2CompletedTreatmentMigraine Disorders1
1, 2CompletedTreatmentOral Dystonia / Tardive Dystonia1
1, 2CompletedTreatmentOsteoarthritis (OA)1
1, 2Not Yet RecruitingTreatmentAbnormal Head Position and Neck Pain for These 7 Muscle Groups: Splenius,Scalene,Sterno-cleido-mastoid,Levator Scapulae,Semispinalis,Trapezius,and Longissimus / Cervical Dystonia Adults 1
1, 2Not Yet RecruitingTreatmentChronic Migraine More than15 Days Per Month, and Lasting 4 Hours a Day or Longer1
1, 2Not Yet RecruitingTreatmentIncreased Muscle Tone in Elbow, Wrist, Finger, and Thumb Flexors / Upper Limb Spasticity Unilaterally in Adults With History of Stroke1
1, 2RecruitingTreatmentCleft Lip / Cleft Palates / Scarring1
1, 2RecruitingTreatmentCluster Headache1
1, 2TerminatedTreatmentEmpty Nose Syndrome / Rhinitis, Atrophic1
1, 2Unknown StatusTreatmentUrge Urinary Incontinence1
2Active Not RecruitingTreatmentDisease, Chronic / Nasal Polyposis / Rhinitis1
2Active Not RecruitingTreatmentObesity, Morbid1
2Active Not RecruitingTreatmentParkinson's Disease (PD)1
2Active Not RecruitingTreatmentRaynaud's Disease1
2Active Not RecruitingTreatmentTremor, Essential1
2Active Not RecruitingTreatmentTremors1
2CompletedTreatmentAmyotrophic Lateral Sclerosis (ALS) / Sialorrhea1
2CompletedTreatmentAnal Fissures1
2CompletedTreatmentBenign Prostatic Hyperplasia (BPH)3
2CompletedTreatmentBotulinum Toxins, Type A1
2CompletedTreatmentBurning Mouth Syndrome1
2CompletedTreatmentCarpal Tunnel Syndrome (CTS)1
2CompletedTreatmentCerebral Palsy (CP)1
2CompletedTreatmentCerebral Palsy (CP) / Equine and Equinovarus Foot Deformation / Spastic Paraplegia and Hemiparesis1
2CompletedTreatmentCerebral Palsy (CP) / Muscle Spasticity1
2CompletedTreatmentCervical Dystonia2
2CompletedTreatmentCervicogenic Headaches1
2CompletedTreatmentChronic Pain Syndrome / Prostatitis1
2CompletedTreatmentChronic Testicular Pain1
2CompletedTreatmentCrows Feet / Facial Wrinkles / Lateral Canthal Lines3
2CompletedTreatmentCrows Feet / Lateral Canthal Lines1
2CompletedTreatmentCutaneous Leiomyomas / Hereditary Leiomyomatosis and Renal Cell Cancer1
2CompletedTreatmentDementias / Paratonia1
2CompletedTreatmentDetrusor Muscle Hyperactivity1
2CompletedTreatmentDiabetes Mellitus (DM) / Muscle Cramps Aggravated1
2CompletedTreatmentEssential Tremor of the Upper Limbs1
2CompletedTreatmentFacial Rhytids1
2CompletedTreatmentGlabellar Frown Lines3
2CompletedTreatmentInterstitial Cystitis1
2CompletedTreatmentLacrimation increased1
2CompletedTreatmentLateral Canthal Lines1
2CompletedTreatmentLow Anterior Resection Syndrome / Rectal Carcinoma1
2CompletedTreatmentMajor Depressive Disorder (MDD)1
2CompletedTreatmentMasticatory Muscles, Hypertrophy of1
2CompletedTreatmentMotor Neurone Disease / Muscle Spasticity / Strokes1
2CompletedTreatmentMuscle Contracture / Muscle Spasticity / Strokes1
2CompletedTreatmentMuscle Spasticity / Strokes2
2CompletedTreatmentMyofascial Pain Syndromes2
2CompletedTreatmentOsteoarthritis (OA)1
2CompletedTreatmentPain of the knee1
2CompletedTreatmentParkinson / Tremors1
2CompletedTreatmentPostherpetic Neuralgia1
2CompletedTreatmentRestless Legs Syndrome (RLS)1
2CompletedTreatmentSkin Aging1
2CompletedTreatmentStomach Neoplasms1
2CompletedTreatmentThoracic Outlet Syndrome1
2CompletedTreatmentUrinary Bladder, Overactive3
2CompletedTreatmentUrinary Bladder, Overactive / Urinary Incontinence (UI)1
2Enrolling by InvitationPreventionPost-operative Excessive Scarring1
2Enrolling by InvitationTreatmentScrotal Pain1
2Not Yet RecruitingTreatmentBenign Masseteric Hypertrophy1
2Not Yet RecruitingTreatmentChronic Scar Pain1
2Not Yet RecruitingTreatmentFunctional Popliteal Artery Entrapment Syndrome / Popliteal artery entrapment syndrome1
2Not Yet RecruitingTreatmentGroin Injury / Tendinopathy1
2Not Yet RecruitingTreatmentPeripheral Neuropathy Due to Chemotherapy1
2Not Yet RecruitingTreatmentTemporo-Myofascial Disorder1
2RecruitingSupportive CareOesophageal Carcinoma1
2RecruitingTreatmentAtrial Flutter1
2RecruitingTreatmentBenign Prostatic Hyperplasia (BPH) / Lower Urinary Track Symptoms1
2RecruitingTreatmentBladder Pain Syndrome1
2RecruitingTreatmentBorderline Personality Disorder (BPD)1
2RecruitingTreatmentCervical Dystonia1
2RecruitingTreatmentDisease, Chronic / Migraine Disorders1
2RecruitingTreatmentFacial Pain1
2RecruitingTreatmentHallux Abductovalgus1
2RecruitingTreatmentHypertrophic Scars1
2RecruitingTreatmentHypertrophy of Masseter Muscle1
2RecruitingTreatmentMigraine Disorders / Migrainous Headache / Pediatrics1
2RecruitingTreatmentNeuropathic Back Pain / Spinal Cord Injuries (SCI)1
2RecruitingTreatmentObstructed Defecation Syndrome (ODS)1
2RecruitingTreatmentOveractive Bladder With Urinary Incontinence / Urinary Incontinence (UI)1
2RecruitingTreatmentPeyronie's Disease1
2RecruitingTreatmentPost-Operative Pain1
2RecruitingTreatmentRotator Cuff Tear Arthropathy1
2RecruitingTreatmentTrigeminal Neuralgia (TN)1
2TerminatedTreatmentAcne Vulgaris1
2TerminatedTreatmentAllodynia / Pain, Neuropathic1
2TerminatedTreatmentBack Pain Lower Back1
2TerminatedTreatmentCerebral Palsy (CP)1
2TerminatedTreatmentCerebral Palsy, Spastic / Pain NOS1
2TerminatedTreatmentHabitual Snoring1
2TerminatedTreatmentNeurogenic Bladder Dysfunction Nos / Spinal Cord Injuries (SCI)1
2TerminatedTreatmentNew Daily Persistent Headache1
2TerminatedTreatmentPain NOS1
2TerminatedTreatmentPremature Ejaculation1
2TerminatedTreatmentUrinary Bladder, Overactive2
2Unknown StatusPreventionScarring1
2Unknown StatusTreatmentArthritis / Pain NOS1
2Unknown StatusTreatmentEpidermolysis Bullosa Simplex1
2Unknown StatusTreatmentHemifacial Spasm1
2Unknown StatusTreatmentRosaceas1
2WithdrawnTreatmentAmyotrophic Lateral Sclerosis (ALS) / Parkinson's Disease (PD)1
2WithdrawnTreatmentContact Ulcer of Vocal Folds / Granuloma / Granuloma of Vocal Cords / Granuloma, Laryngeal1
2WithdrawnTreatmentLower Urinary Tract Symptoms (LUTS) / Prostate Cancer / Radioactive Seed Implantation1
2WithdrawnTreatmentUrinary Bladder, Overactive / Urinary Incontinence (UI)1
2, 3CompletedPreventionScarring1
2, 3CompletedTreatmentBenign Prostatic Enlargement (BPE) / Benign Prostatic Hyperplasia (BPH)1
2, 3CompletedTreatmentFowler's Syndrome / Urinary Retention1
2, 3CompletedTreatmentPlantar Fasciitis, Chronic1
2, 3CompletedTreatmentRecalcitrant Alopecia Totalis / Recalcitrant Alopecia Universalis1
2, 3CompletedTreatmentRefractory Migraine1
2, 3CompletedTreatmentSialorrhea1
2, 3Not Yet RecruitingTreatmentBase-of-thumb Osteoarthritis1
2, 3Not Yet RecruitingTreatmentEpidermolysis Bullosa Simplex1
2, 3RecruitingTreatmentBlepharospasm1
2, 3RecruitingTreatmentCrows Feet Lines1
2, 3RecruitingTreatmentErectile Dysfunction (ED) / Sexual Dysfunctions1
2, 3TerminatedTreatmentPrimary Focal Hyperhidrosis of the Hands1
2, 3Unknown StatusPreventionForward Head Posture With Associated Episodic Headache Disorder1
2, 3Unknown StatusTreatmentCerebral Palsy (CP) / Sialorrhea1
2, 3Unknown StatusTreatmentLower Limb Spasticity After Stroke1
2, 3Unknown StatusTreatmentNon-relaxing Puborectalis Syndrome1
2, 3Unknown StatusTreatmentUrinary Bladder, Overactive1
3Active Not RecruitingTreatmentCerebral Palsy (CP) / Chronic Troublesome Sialorrhea / Disability, Intellectual / Strokes / Traumatic Brain Injury (TBI)1
3Active Not RecruitingTreatmentComparison between group treated with botulinum toxin and placebo1
3CompletedNot AvailableAging1
3CompletedSupportive CareBRCA1 Mutations / BRCA2 Mutation / Breast Diseases / Cancer, Breast / Neoplasms / Postoperative pain1
3CompletedSupportive CareStroke With Hemiparesis1
3CompletedTreatmentAllodynia / Headaches1
3CompletedTreatmentBack Pain Lower Back1
3CompletedTreatmentBack Pain Lower Back Chronic1
3CompletedTreatmentBilateral Blepharospasm (BEB)1
3CompletedTreatmentCanthal Lines1
3CompletedTreatmentCerebral Palsy (CP)1
3CompletedTreatmentCerebral Palsy (CP) / Children / Muscle Spasticity2
3CompletedTreatmentCerebral Palsy (CP) / Muscle Spasticity / Pediatrics2
3CompletedTreatmentCerebral Palsy (CP) / Muscle Spasticity / Pediatrics / Strokes2
3CompletedTreatmentCerebral Palsy (CP) / Spasticity1
3CompletedTreatmentCerebrovascular Accidents3
3CompletedTreatmentCervical Dystonia5
3CompletedTreatmentChronic Troublesome Sialorrhea / Parkinson's Disease (PD) / Post-stroke / Traumatic Brain Injury (TBI)1
3CompletedTreatmentCrow's Feet Lines / Facial Rhytides / Glabellar Lines2
3CompletedTreatmentCrow's Feet Lines / Frown Lines / Glabellar Lines / Upper Facial Rhytides1
3CompletedTreatmentCrow's Feet Lines / Lateral Canthal Lines1
3CompletedTreatmentCrow's Feet Lines / Lateral Canthus Rhytides2
3CompletedTreatmentDisseminated Sclerosis / Neurogenic Bladder Dysfunction / Urinary Incontinence (UI)1
3CompletedTreatmentDisseminated Sclerosis / Tremors1
3CompletedTreatmentEssential Blepharospasm2
3CompletedTreatmentFacial Rhytides / Glabellar Rhytides1
3CompletedTreatmentForehead Rhytides / Glabellar Rhytides1
3CompletedTreatmentFrown Lines Between the Eyebrows / Glabellar Rhytides1
3CompletedTreatmentGlabellar Frown Lines1
3CompletedTreatmentGlabellar Lines4
3CompletedTreatmentGlabellar Lines / Moderate to Severe Glabellar Lines1
3CompletedTreatmentGlabellar Rhytides2
3CompletedTreatmentLateral Epicondylitis1
3CompletedTreatmentLateral Periorbital Wrinkles1
3CompletedTreatmentLeg Spasticity1
3CompletedTreatmentLower Extremity Deformities, Congenital / Unequal Length of Limbs; Congenital1
3CompletedTreatmentLower Limb Spasticity Due to Cerebral Palsy1
3CompletedTreatmentLower Limb and Combined Lower Limb and Upper Limb Spasticity Due to Cerebral Palsy1
3CompletedTreatmentMigraine Disorders3
3CompletedTreatmentModerate to Severe Glabellar Line1
3CompletedTreatmentMuscle Spasticity1
3CompletedTreatmentMyofascial Pain Syndromes1
3CompletedTreatmentNervous System Disorders2
3CompletedTreatmentNeurogenic Detrusor Overactivity1
3CompletedTreatmentNotalgia Paresthetica1
3CompletedTreatmentOther Infantile Cerebral Palsy1
3CompletedTreatmentPost-stroke Spasticity of the Lower Limb1
3CompletedTreatmentPost-stroke Spasticity of the Upper Limb1
3CompletedTreatmentPost-stroke Upper Limb Spasticity1
3CompletedTreatmentRaynaud's Syndrome / Scleroderma1
3CompletedTreatmentRefractory Urge Urinary Incontinence / Urinary Incontinence, Urge1
3CompletedTreatmentSkin Aging5
3CompletedTreatmentSpasticity Post-Traumatic Brain Injury / Spasticity, Post-Stroke1
3CompletedTreatmentSpasticity of the Upper and Lower Limb Due to Cerebral Causes1
3CompletedTreatmentSpasticity, Post-Stroke1
3CompletedTreatmentSpasticity / Strokes2
3CompletedTreatmentUpper Limb Spasticity1
3CompletedTreatmentUpper Limb Spasticity (Altered Skeletal Muscle Performance) in Children1
3CompletedTreatmentUrinary Bladder, Overactive5
3CompletedTreatmentUrinary Bladder, Overactive / Urinary Incontinence (UI)2
3CompletedTreatmentUrinary Incontinence (UI)1
3CompletedTreatmentFacial fine wrinkling1
3Enrolling by InvitationTreatmentChronic Migraine1
3Enrolling by InvitationTreatmentUrinary Bladder, Overactive1
3Not Yet RecruitingTreatmentCerebral Palsy (CP)1
3Not Yet RecruitingTreatmentCerebrovascular Accidents1
3Not Yet RecruitingTreatmentExcessive Gingival Display1
3Not Yet RecruitingTreatmentTrigeminal Neuropathy, Traumatic1
3RecruitingPreventionIntercanthal Distance Ratio / Scarring1
3RecruitingTreatmentAcquired Esotropia1
3RecruitingTreatmentCerebral Palsy (CP)2
3RecruitingTreatmentCerebrovascular Accidents1
3RecruitingTreatmentCrow's Feet Lines2
3RecruitingTreatmentDisseminated Sclerosis / Spasticity, Muscle1
3RecruitingTreatmentHyperhidrosis / Residual Limbs1
3RecruitingTreatmentLateral Epicondylitis1
3RecruitingTreatmentMuscle Spasticity1
3RecruitingTreatmentMyofascial Pain Syndrome / Pain Syndrome / Pain, Head / Temporomandibular Disorders1
3RecruitingTreatmentObstetrical Brachial Plexus Palsy1
3RecruitingTreatmentRaynaud Phenomenon Secondary to Systemic Sclerosis1
3RecruitingTreatmentTrigeminal Neuralgia (TN)1
3RecruitingTreatmentUrinary Bladder, Overactive1
3RecruitingTreatmentUrinary Bladder, Overactive / Urinary Incontinence (UI)3
3RecruitingTreatmentUrinary Incontinence (UI)1
3TerminatedTreatmentChronic Post Traumatic Headache1
3TerminatedTreatmentChronic Prostatitis With Chronic Pelvic Pain Syndrome / Prostatitis1
3TerminatedTreatmentDetrusor Hyperreflexia / Urge Incontinence / Urinary Bladder, Overactive / Urinary Incontinence (UI) / Urinary Urge Incontinence1
3TerminatedTreatmentDetrusor Overactivity / Urge Urinary Incontinence / Urinary Incontinence (UI) / Urination urgency of1
3TerminatedTreatmentLower Urinary Tract Discomfort / Stent Pain1
3TerminatedTreatmentMuscle Spasticity / Strokes1
3TerminatedTreatmentPatellofemoral Pain Syndrome1
3TerminatedTreatmentSkin Aging1
3TerminatedTreatmentUrinary Bladder, Overactive1
3Unknown StatusTreatmentHemiplegic Patients Post-AVC1
3Unknown StatusTreatmentScarring1
3Unknown StatusTreatmentUrinary Bladder, Overactive1
3Unknown StatusTreatmentFacial fine wrinkling1
3WithdrawnOtherNeurocostal neuralgia / Pain Due to Certain Specified Procedures / Pain, Neuropathic1
3WithdrawnPreventionMigraine Disorders2
3WithdrawnTreatmentMuscle Spasticity / Strokes1
4Active Not RecruitingTreatmentBlepharospasm / Botulinum Toxins, Type A / Hemifacial Spasm1
4Active Not RecruitingTreatmentChronic Idiopathic Constipation / Functional Constipation1
4Active Not RecruitingTreatmentParkinson's Disease (PD)1
4Active Not RecruitingTreatmentUrinary Bladder, Overactive / Urinary Incontinence (UI)1
4CompletedNot AvailableHealthy Subjects, Only With Wrinkles on Forehead1
4CompletedNot AvailableUrinary Bladder, Overactive1
4CompletedBasic ScienceHealthy Volunteers1
4CompletedPreventionMigraine Disorders2
4CompletedPreventionPainful Bladder Syndrome (PBS) / Urinary Bladder, Neurogenic / Urinary Bladder, Overactive / Urinary Urge Incontinence1
4CompletedPreventionStrokes / Upper Limb Spasticity1
4CompletedTreatmentBrain Injury / Spasticity Secondary to Either a Disorder or Trauma / Spinal Cord Injuries (SCI) / Strokes / Tumors1
4CompletedTreatmentBrain Injury / Spasticity / Strokes1
4CompletedTreatmentBrow Ptosis1
4CompletedTreatmentBrow Ptosis / Lid Ptosis1
4CompletedTreatmentCerebral Palsy (CP)1
4CompletedTreatmentCerebral Palsy and Botulinum Toxin1
4CompletedTreatmentCerebrovascular Accidents / Muscle Spasticity2
4CompletedTreatmentCervical Dystonia4
4CompletedTreatmentChronic Migraine5
4CompletedTreatmentCrow's Feet Lines / Facial Rhytides / Glabellar Lines / Nasolabial Folds1
4CompletedTreatmentDiabetic Polyneuropathies / Other Polyneuropathies / Postherpetic Neuralgia1
4CompletedTreatmentDisseminated Sclerosis / Muscle Spasticity1
4CompletedTreatmentEsotropia / Exotropia1
4CompletedTreatmentEssential Blepharospasm2
4CompletedTreatmentFacial Asymmetry / Facial Nerve Injuries / Facial Paresis Associated With Facial Nerve Dysfunction / Synkinesis1
4CompletedTreatmentFacial Rhytides1
4CompletedTreatmentGlabellar Frown Lines3
4CompletedTreatmentGlabellar Furrows1
4CompletedTreatmentGlabellar Lines1
4CompletedTreatmentGlabellar Rhytides1
4CompletedTreatmentHallux Valgus1
4CompletedTreatmentInterstitial Cystitis1
4CompletedTreatmentInterstitial Cystitis / Painful Bladder Syndrome (PBS)1
4CompletedTreatmentIntrinsic Aging of Skin / Solar Elastosis1
4CompletedTreatmentMigraine Disorders2
4CompletedTreatmentMild to Moderate Temporal Atrophy / Moderate to Severe Glabellar Rhytids / Moderate to Severe Periorbital Rhytids1
4CompletedTreatmentMuscle Spasticity1
4CompletedTreatmentPain, Neuropathic / Spinal Cord Injuries (SCI)1
4CompletedTreatmentPlantar Fascitis1
4CompletedTreatmentSkin Aging1
4CompletedTreatmentSpasmodic Torticollis1
4CompletedTreatmentSpastic Hemiplegia1
4CompletedTreatmentSpastic Hemiplegia / Spasticity as Sequela of Stroke / Strokes1
4CompletedTreatmentStroke Rehabilitation / Stroke Rehabilitation Spasticity Management1
4CompletedTreatmentSun-induced Wrinkles1
4CompletedTreatmentUpper Limb Spasticity1
4CompletedTreatmentUrinary Bladder, Overactive1
4CompletedTreatmentUrinary Bladder, Overactive / Urinary Incontinence (UI)1
4CompletedTreatmentWrinkles in Frontal Area1
4CompletedTreatmentFacial fine wrinkling1
4Enrolling by InvitationTreatmentAchalasia1
4Not Yet RecruitingTreatmentActivity / Pain NOS1
4Not Yet RecruitingTreatmentEquinovarus; Acquired1
4Not Yet RecruitingTreatmentFacial Rhytides, Skin Folds, Loss of Volume and Skin Quality1
4RecruitingBasic ScienceMigraines1
4RecruitingOtherGlabellar Frown Lines1
4RecruitingOtherMuscle Spasticity / Strokes1
4RecruitingPreventionOther Degenerative Disorders of Eyelid and Periocular Area1
4RecruitingTreatmentBreast Diseases / Neoplasms / Neoplasms by Site / Neoplasms, Breast / Skin Diseases1
4RecruitingTreatmentBrow Lifting1
4RecruitingTreatmentCerebral Palsy (CP) / Muscle Spasticity1
4RecruitingTreatmentKnee Osteoarthritis (Knee OA)1
4RecruitingTreatmentMixed Urinary Incontinence / Stress Urinary Incontinence (SUI) / Urgency Incontinence1
4RecruitingTreatmentPain, Face1
4RecruitingTreatmentPainful Intercourse / Pelvic Floor Dysfunctions / Pelvic Pain1
4RecruitingTreatmentRaynaud's Phenomenon1
4RecruitingTreatmentUrinary Bladder, Overactive / Urinary Frequency/Urgency / Urinary Incontinence (UI) / Urination urgency of1
4TerminatedTreatmentAnxiety Disorder Social / Feeling Anxious1
4TerminatedTreatmentArthritis Multiple Joint / Basal Thumb Joint Arthritis / Basilar Joint Arthritis / Carpometacarpal Arthritis / Trapeziometacarpal Arthritis1
4TerminatedTreatmentBack Pain Lower Back1
4TerminatedTreatmentChronic Male Pelvic Pain Syndrome1
4TerminatedTreatmentParkinson's Disease (PD)1
4TerminatedTreatmentSpasmodic Torticollis1
4Unknown StatusPreventionAutonomic Dysreflexia1
4Unknown StatusTreatmentBack Pain Lower Back Chronic1
4Unknown StatusTreatmentBruxism1
4Unknown StatusTreatmentCatocholamine Induced Finger Necrosis1
4Unknown StatusTreatmentElastosis Senilis / Skin Aging1
4Unknown StatusTreatmentMajor Depressive Disorder (MDD)1
4Unknown StatusTreatmentMuscle Spasticity1
4Unknown StatusTreatmentOveractive Detrusor1
4Unknown StatusTreatmentSleep Bruxism1
4WithdrawnTreatmentFoot Deformities / Leg Length Inequality1
4WithdrawnTreatmentGraves Ophthalmopathy1
Not AvailableActive Not RecruitingNot AvailableDysphonia1
Not AvailableActive Not RecruitingTreatmentFacial Flushing1
Not AvailableActive Not RecruitingTreatmentHeadaches1
Not AvailableActive Not RecruitingTreatmentIdiopathic Clubfoot (Talipes Equinovarus)1
Not AvailableActive Not RecruitingTreatmentMyofascial Pelvic Pain1
Not AvailableActive Not RecruitingTreatmentFacial fine wrinkling1
Not AvailableCompletedNot AvailableBlepharospasm / Cervical Dystonia1
Not AvailableCompletedNot AvailableCerebral Palsy (CP)1
Not AvailableCompletedNot AvailableChronic Migraine, Headaches1
Not AvailableCompletedNot AvailableCrow's Feet Lines / Lateral Canthal Lines1
Not AvailableCompletedNot AvailableFacial Rhytides1
Not AvailableCompletedNot AvailableGlabellar Lines1
Not AvailableCompletedNot AvailableGlabellar Lines / Hyperhidrosis / Muscle Spasticity1
Not AvailableCompletedNot AvailableHeadaches / Migraine Disorders1
Not AvailableCompletedNot AvailableLower Limb Spasticity1
Not AvailableCompletedNot AvailableMigraine Disorders1
Not AvailableCompletedNot AvailableMumps1
Not AvailableCompletedNot AvailableMuscle Spasticity2
Not AvailableCompletedNot AvailableSkin Laxity1
Not AvailableCompletedNot AvailableSpasticity, Post-Stroke1
Not AvailableCompletedNot AvailableTorticollis1
Not AvailableCompletedNot AvailableUrinary Bladder, Neurogenic / Urinary Bladder, Overactive1
Not AvailableCompletedNot AvailableUrinary Bladder, Overactive / Urinary Incontinence (UI)3
Not AvailableCompletedNot AvailableUrinary Incontinence (UI)1
Not AvailableCompletedDiagnosticBotulinum Toxins, Type A / Normal, Healthy Volunteers / Strength, Muscle1
Not AvailableCompletedHealth Services ResearchHealthy Volunteers1
Not AvailableCompletedHealth Services ResearchMuscle Spasticity / Strokes1
Not AvailableCompletedPreventionHerpes Labialis1
Not AvailableCompletedPreventionPost Traumatic Stiffness1
Not AvailableCompletedSupportive CarePain NOS1
Not AvailableCompletedTreatmentAchalasia, Esophageal1
Not AvailableCompletedTreatmentAxillary Hyperhidrosis1
Not AvailableCompletedTreatmentBotulinum Toxin / Cerebral Palsy, Spastic / Physical Therapy1
Not AvailableCompletedTreatmentCerebral Palsy (CP) / Muscle Spasticity1
Not AvailableCompletedTreatmentDiabetes Mellitus (DM) / Pain, Neuropathic1
Not AvailableCompletedTreatmentDiabetes Mellitus (DM) / Peripheral Neuropathy / Plantar Ulcers1
Not AvailableCompletedTreatmentEpicondylitis, Lateral Humeral / Lateral Epicondylitis1
Not AvailableCompletedTreatmentFacial Paralysis1
Not AvailableCompletedTreatmentFacial Rhytides / Glabellar Frown Lines1
Not AvailableCompletedTreatmentFacial Wrinkles1
Not AvailableCompletedTreatmentHIV Posterior Cheek Enlargement1
Not AvailableCompletedTreatmentHyperhidrosis1
Not AvailableCompletedTreatmentIdiopathic Clubfoot (Talipes Equinovarus)1
Not AvailableCompletedTreatmentKeratoconus1
Not AvailableCompletedTreatmentNon-neurogenic / Urinary Urge Incontinence1
Not AvailableCompletedTreatmentPain NOS1
Not AvailableCompletedTreatmentPelvic Pain1
Not AvailableCompletedTreatmentPost-stroke Shoulder Pain and Spasticity1
Not AvailableCompletedTreatmentPrimary Axillary Hyperhidrosis1
Not AvailableCompletedTreatmentRaynaud's Syndrome1
Not AvailableCompletedTreatmentSkin Wrinklings1
Not AvailableCompletedTreatmentSpastic Equinovarus1
Not AvailableCompletedTreatmentSubacute Cervical Pain / Subacute Upper Back Pain1
Not AvailableCompletedTreatmentTremor, Essential1
Not AvailableCompletedTreatmentUrinary Incontinence (UI)1
Not AvailableCompletedTreatmentVaginismus1
Not AvailableEnrolling by InvitationNot AvailableUnilateral Spastic Cerebral Palsy1
Not AvailableRecruitingNot AvailableCerebral Palsy (CP)1
Not AvailableRecruitingNot AvailableDetrusor, Overactive / Disseminated Sclerosis / Lower Urinary Tract Symptoms (LUTS) / Neurogenic Bladder Dysfunction / Urge Incontinence1
Not AvailableRecruitingNot AvailableEsthetic Outcome of Injection of Botulinum Toxin Type-A in Cleft Lip Repair1
Not AvailableRecruitingNot AvailableLower Limb Spasticity1
Not AvailableRecruitingNot AvailableMixed Incontinence, Urge and Stress1
Not AvailableRecruitingNot AvailableUrinary Bladder, Overactive1
Not AvailableRecruitingTreatmentChronic Vocal Tic / Gilles de la Tourette's Syndrome1
Not AvailableRecruitingTreatmentEpicondylitis, Lateral Humeral / Lateral Epicondylitis1
Not AvailableRecruitingTreatmentGingival Exposure1
Not AvailableRecruitingTreatmentHemifacial Spasm1
Not AvailableRecruitingTreatmentMigrainous Headache1
Not AvailableRecruitingTreatmentPlantar fascial fibromatosis1
Not AvailableSuspendedTreatmentPain NOS1
Not AvailableTerminatedNot AvailableCerebral Palsy (CP)1
Not AvailableTerminatedTreatmentBrain Injury / Stiff Knee Gait1
Not AvailableTerminatedTreatmentEquinus Contracture1
Not AvailableTerminatedTreatmentErythema and Flushing Associated With Rosacea1
Not AvailableTerminatedTreatmentMigrainous Headache1
Not AvailableTerminatedTreatmentTransient ischemia attacks / Vasopressor1
Not AvailableUnknown StatusTreatmentAlopecia Areata (AA)1
Not AvailableUnknown StatusTreatmentEsophageal Spasm, Diffuse1
Not AvailableUnknown StatusTreatmentFlexion Contracture Following Total Knee Replacement1
Not AvailableUnknown StatusTreatmentLateral Epicondylitis / Type A Botulinum Toxin1
Not AvailableWithdrawnNot AvailableChronic Migraine, Headaches1


Not Available
  • Allergan Inc.
  • Tercica Inc.
Dosage forms
Injection, powder, lyophilized, for solutionIntradermal; Intramuscular100 [USP'U]/1
Injection, powder, lyophilized, for solutionIntradermal; Intramuscular200 [USP'U]/1
Powder, for solutionIntramuscular100 unit
Injection, powder, lyophilized, for solutionIntramuscular100 [USP'U]/1
Injection, powder, lyophilized, for solutionIntramuscular50 [USP'U]/1
Injection, powder, lyophilized, for solutionIntramuscular300 U/1
Injection, powder, lyophilized, for solutionIntramuscular300 [USP'U]/1
Injection, powder, lyophilized, for solutionIntramuscular500 U/1
Powder, for solutionIntramuscular300 unit
Powder, for solutionIntramuscular500 unit
Injection, powder, lyophilized, for solutionIntramuscular200 [USP'U]/1
Powder, for solutionIntramuscular50 unit
Unit descriptionCostUnit
Botox 200 unit vial1260.0USD vial
Dysport 500 unit vial852.0USD vial
Botox 100 unit655.2USD vial
Botox 100 unit vial630.0USD vial
Botox cosmetic 100 unit vial630.0USD vial
Botox cosmetic 50 unit vial346.8USD vial
Botox (100 - 200 unit/Vial)3.74USD vial
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patent NumberPediatric ExtensionApprovedExpires (estimated)


Experimental Properties
water solubilitySolubleNot Available
hydrophobicity-0.368Not Available
isoelectric point6.06Not Available


Not Available
Organic Compounds
Super Class
Organic Acids
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Alternative Parents
Not Available
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available


Pharmacological action
General Function
Syntaxin-1 binding
Specific Function
t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesi...
Gene Name
Uniprot ID
Uniprot Name
Synaptosomal-associated protein 25
Molecular Weight
23314.905 Da
  1. Zhou JY, Wang ZF, Ren XM, Tang MZ, Shi YL: Antagonism of botulinum toxin type A-induced cleavage of SNAP-25 in rat cerebral synaptosome by toosendanin. FEBS Lett. 2003 Dec 4;555(2):375-9. [PubMed:14644446]
  2. Flynn TC: Myobloc. Dermatol Clin. 2004 Apr;22(2):207-11, vii. [PubMed:15222581]
  3. Okada M, Yoshida S, Zhu G, Kaneko S: [Methodological consideration in studying the exocytosis mechanisms using microdialysis]. Nihon Shinkei Seishin Yakurigaku Zasshi. 2004 Aug;24(4):165-70. [PubMed:15484814]
  4. Frassoni C, Inverardi F, Coco S, Ortino B, Grumelli C, Pozzi D, Verderio C, Matteoli M: Analysis of SNAP-25 immunoreactivity in hippocampal inhibitory neurons during development in culture and in situ. Neuroscience. 2005;131(4):813-23. [PubMed:15749336]
  5. Straughan D: Progress in applying the Three Rs to the potency testing of Botulinum toxin type A. Altern Lab Anim. 2006 Jun;34(3):305-13. [PubMed:16831062]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
Pharmacological action
General Function
Gtpase activity
Specific Function
Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative r...
Gene Name
Uniprot ID
Uniprot Name
Rho-related GTP-binding protein RhoB
Molecular Weight
22123.185 Da
  1. Ishida H, Zhang X, Erickson K, Ray P: Botulinum toxin type A targets RhoB to inhibit lysophosphatidic acid-stimulated actin reorganization and acetylcholine release in nerve growth factor-treated PC12 cells. J Pharmacol Exp Ther. 2004 Sep;310(3):881-9. Epub 2004 May 12. [PubMed:15140914]

Drug created on June 13, 2005 07:24 / Updated on November 18, 2018 13:32