Botulinum toxin type A

Identification

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Name
Botulinum toxin type A
Accession Number
DB00083  (BTD00092, BIOD00092)
Type
Biotech
Groups
Approved, Investigational
Biologic Classification
Protein Based Therapies
Other protein based therapies
Description

Purified botulinum toxin from Clostridium botulinum, purified from culture via dialysis and acid precipitation.

Protein structure
Db00083
Protein chemical formula
C6760H10447N1743O2010S32
Protein average weight
149322.7 Da
Sequences
>Botulinum Toxin Type A Sequence
MPFVNKQFNYKDPVNGVDIAYIKIPNVGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLN
PPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGG
STIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGY
GSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPN
RVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKA
KSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKV
LNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFT
GLFEFYKLLCVRGIITSKTKSLDKGYNKALNDLCIKVNNWDLFFSPSEDNFTNDLNKGEE
ITSDTNIEAAEENISLDLIQQYYLTFNFDNEPENISIENLSSDIIGQLELMPNIERFPNG
KKYELDKYTMFHYLRAQEFEHGKSRIALTNSVNEALLNPSRVYTFFSSDYVKKVNKATEA
AMFLGWVEQLVYDFTDETSEVSTTDKIADITIIIPYIGPALNIGNMLYKDDFVGALIFSG
AVILLEFIPEIAIPVLGTFALVSYIANKVLTVQTIDNALSKRNEKWDEVYKYIVTNWLAK
VNTQIDLIRKKMKEALENQAEATKAIINYQYNQYTEEEKNNINFNIDDLSSKLNESINKA
MININKFLNQCSVSYLMNSMIPYGVKRLEDFDASLKDALLKYIYDNRGTLIGQVDRLKDK
VNNTLSTDIPFQLSKYVDNQRLLSTFTEYIKNIINTSILNLRYESNHLIDLSRYASKINI
GSKVNFDPIDKNQIQLFNLESSKIEVILKNAIVYNSMYENFSTSFWIRIPKYFNSISLNN
EYTIINCMENNSGWKVSLNYGEIIWTLQDTQEIKQRVVFKYSQMINISDYINRWIFVTIT
NNRLNNSKIYINGRLIDQKPISNLGNIHASNNIMFKLDGCRDTHRYIWIKYFNLFDKELN
EKEIKDLYDNQSNSGILKDFWGDYLQYDKPYYMLNLYDPNKYVDVNNVGIRGYMYLKGPR
GSVMTTNIYLNSSLYRGTKFIIKKYASGNKDNIVRNNDRVYINVVVKNKEYRLATNASQA
GVEKILSALEIPDVGNLSQVVVMKSKNDQGITNKCKMNLQDNNGNDIGFIGFHQFNNIAK
LVASNWYNRQIERSSRTLGCSWEFIPVDDGWGERPL
Download FASTA Format
Synonyms
  • AbobotulinumtoxinA
  • Botulinum A neurotoxin
  • Botulinum toxin A
  • Botulinum toxin type A
  • BTX-A
  • Evabotulinumtoxina
  • IncobotulinumtoxinA
  • OnabotulinumtoxinA
  • Prabotulinumtoxin A
  • Toxina botulĂ­nica A
  • Toxine botulinique A
External IDs
AGN 191622 / ANT-1207 / ANT-1401 / ANT-1403 / NT 201
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
BotoxInjection, powder, lyophilized, for solution100 [USP'U]/1Intradermal; IntramuscularAllergan, Inc.1989-12-15Not applicableUs
BotoxInjection, powder, lyophilized, for solution200 [USP'U]/1Intradermal; IntramuscularAllergan, Inc.2010-01-11Not applicableUs
BotoxPowder, for solution100 unitIntramuscularAllergan1992-12-31Not applicableCanada
BOTOX CosmeticInjection, powder, lyophilized, for solution100 [USP'U]/1IntramuscularAllergan, Inc.2008-05-20Not applicableUs
BOTOX CosmeticInjection, powder, lyophilized, for solution50 [USP'U]/1IntramuscularAllergan, Inc.2008-07-15Not applicableUs
BOTOX CosmeticPowder, for solution100 unitIntramuscularAllergan2001-05-07Not applicableCanada
DysportInjection, powder, lyophilized, for solution300 U/1IntramuscularIpsen Biopharmaceuticals, Inc.2009-11-02Not applicableUs
DysportInjection, powder, lyophilized, for solution500 U/1IntramuscularIpsen Biopharmaceuticals, Inc.2009-11-02Not applicableUs
DysportInjection, powder, lyophilized, for solution300 U/1IntramuscularGalderma Laboratories, L.P.2009-11-02Not applicableUs
DysportInjection, powder, lyophilized, for solution300 [USP'U]/1IntramuscularMedicis Pharmaceutical Corporation2009-05-252015-03-31Us
Additional Data Available
  • Application Number
    Application Number

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  • Product Code
    Product Code

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Categories
UNII
E211KPY694
CAS number
93384-43-1

Pharmacology

Indication

For the treatment of cervical dystonia in adults to decrease the severity of abnormal head position and neck pain associated with cervical dystonia. Also for the treatment of severe primary axillary hyperhidrosis that is inadequately managed with topical agents and for the treatment of strabismus and blepharospasm associated with dystonia, including benign essential blepharospasm or VII nerve disorders in patients 12 years of age and above. Also used cosmetically to temporarily improve the appearance of moderate-to-severe frown lines between the eyebrows (glabellar lines) as well as for the treatment of excessive underarm sweating.

Associated Conditions
Associated Therapies
Pharmacodynamics

A 150 kDa neurotoxic protein produced from fermentation of Hall strain Clostridium botulinum type A grown in a medium containing casein hydrolysate, glucose and yeast extract. It is purified from the culture solution by dialysis and a series of acid precipitations to a complex consisting of the neurotoxin, and several accessory proteins. Botulinum Toxin Type A is not expected to be present in the peripheral blood at measurable levels following IM or intradermal injection at the recommended doses. The recommended quantities of neurotoxin administered at each treatment session are not expected to result in systemic, overt distant clinical effects, i.e. muscle weakness, in patients without other neuromuscular dysfunction. However, sub-clinical systemic effects have been shown by single-fiber electromyography after IM doses of botulinum toxins appropriate to produce clinically observable local muscle weakness.

Mechanism of action

Botulinum Toxin Type A blocks neuromuscular transmission by binding to acceptor sites on motor or sympathetic nerve terminals, entering the nerve terminals, and inhibiting the release of acetylcholine. This inhibition occurs as the neurotoxin cleaves SNAP-25, a protein integral to the successful docking and release of acetylcholine from vesicles situated within nerve endings.

TargetActionsOrganism
ASynaptosomal-associated protein 25
inhibitor
Humans
URho-related GTP-binding protein RhoBNot AvailableHumans
Additional Data Available
Adverse Effects

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption

The chemical complexity of Botulinum Toxin Type A combined with its extreme potency limits the opportunity to study its pharmacokinetic profile in humans. Therefore, no human pharmacokinetic studies have been performed. Botulinum Toxin Type A is injected directly into the target organ, a skeletal muscle. Thus, bioavailability of the intravenous or oral route is not of clinical relevance.

Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity

Based on toxicological studies, it has been estimated that the human LD50 by injection is approximately 2800 Units, equivalent to 28 individual vials of BOTOX (Botulinum Toxin Type A) Purified Neurotoxin Complex (100 Units) for a 70 kg adult. When injected intramuscularly, Botulinum Toxin Type A has been shown to be teratogenic or to have embryocidal effects in some animal species.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
2,5-Dimethoxy-4-ethylthioamphetamineThe risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with 2,5-Dimethoxy-4-ethylthioamphetamine.
4-Bromo-2,5-dimethoxyamphetamineThe risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with 4-Bromo-2,5-dimethoxyamphetamine.
4-MethoxyamphetamineThe risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with 4-Methoxyamphetamine.
5-methoxy-N,N-dimethyltryptamineThe risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with 5-methoxy-N,N-dimethyltryptamine.
7-NitroindazoleThe risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with 7-Nitroindazole.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinolineThe risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.
AcepromazineThe risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Acepromazine.
AceprometazineThe risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Aceprometazine.
AcetazolamideThe risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Acetazolamide.
AcetophenazineThe risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Acetophenazine.
Additional Data Available
  • Extended Description
    Extended Description

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  • Severity
    Severity

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  • Evidence Level
    Evidence Level

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  • Action
    Action

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Food Interactions
Not Available

References

General References
  1. Montecucco C, Molgo J: Botulinal neurotoxins: revival of an old killer. Curr Opin Pharmacol. 2005 Jun;5(3):274-9. [PubMed:15907915]
  2. Brin MF, Lew MF, Adler CH, Comella CL, Factor SA, Jankovic J, O'Brien C, Murray JJ, Wallace JD, Willmer-Hulme A, Koller M: Safety and efficacy of NeuroBloc (botulinum toxin type B) in type A-resistant cervical dystonia. Neurology. 1999 Oct 22;53(7):1431-8. [PubMed:10534247]
  3. Shukla HD, Sharma SK: Clostridium botulinum: a bug with beauty and weapon. Crit Rev Microbiol. 2005;31(1):11-8. [PubMed:15839401]
  4. Eisenach JH, Atkinson JL, Fealey RD: Hyperhidrosis: evolving therapies for a well-established phenomenon. Mayo Clin Proc. 2005 May;80(5):657-66. [PubMed:15887434]
  5. Schurch B, Corcos J: Botulinum toxin injections for paediatric incontinence. Curr Opin Urol. 2005 Jul;15(4):264-7. [PubMed:15928517]
External Links
UniProt
P10845
Genbank
X52066
KEGG Drug
D00783
KEGG Compound
C07946
PubChem Substance
46505347
Therapeutic Targets Database
DAP001298
PharmGKB
PA164754825
RxList
RxList Drug Page
Wikipedia
Botox
ATC Codes
M03AX01 — Botulinum toxin
AHFS Codes
  • 92:92.00 — Other Miscellaneous Therapeutic Agents
FDA label
Download (115 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedTreatmentBenign Prostatic Hyperplasia (BPH)1
0CompletedTreatmentBladder Pain Syndrome1
0CompletedTreatmentStroke1
0Not Yet RecruitingTreatmentBilateral Vocal Fold Paralysis (BVFP)1
0Not Yet RecruitingTreatmentGummy Smile Due to Hypermobile Upper Lip1
0RecruitingTreatmentComplex Regional Pain Syndrome (CRPS)1
0RecruitingTreatmentSecondary Headache Disorder1
0TerminatedTreatmentNeuralgia1
0WithdrawnDiagnosticBenign Prostatic Hyperplasia (BPH) / Enlarged Prostate With Lower Urinary Tract Symptoms (LUTS) / Prostate Cancer1
1Active Not RecruitingTreatmentPruritus1
1CompletedBasic ScienceHealthy Volunteers2
1CompletedOtherPsoriasis Vulgaris (Plaque Psoriasis)1
1CompletedScreeningHealthy Volunteers1
1CompletedTreatmentAnhidrotic Area / Hyperhidrosis1
1CompletedTreatmentBMI >30 kg/m22
1CompletedTreatmentCerebral Palsy (CP) / Spasticity1
1CompletedTreatmentDry Eye Syndromes1
1CompletedTreatmentHyperhidrosis1
1CompletedTreatmentKnee Osteoarthritis (Knee OA)1
1CompletedTreatmentPsoriasis Vulgaris (Plaque Psoriasis)1
1CompletedTreatmentScrotal Pain1
1CompletedTreatmentUrinary Bladder, Overactive1
1CompletedTreatmentVaginismus1
1CompletedTreatmentVasculogenic Erectile Dysfunction1
1CompletedTreatmentWound; Abdomen, Abdominal Wall1
1Not Yet RecruitingTreatmentCervical Dystonia1
1Not Yet RecruitingTreatmentGingival Overgrowth1
1Not Yet RecruitingTreatmentMajor Depressive Disorder (MDD) / Major Depressive Episode / Treatment Resistant Depression (TRD)1
1RecruitingTreatmentBack Pain Lower Back / Neck Pain1
1RecruitingTreatmentBotulinum Toxins, Type A / Plantar Fascitis1
1RecruitingTreatmentDepression / Parkinson's Disease (PD)1
1RecruitingTreatmentHyperhidrosis1
1RecruitingTreatmentMyofascial Pain Syndromes / Myofascial Trigger Point Pain / Trigger Point Pain, Myofascial1
1TerminatedTreatmentChronic Pain Syndrome / Prostatitis1
1TerminatedTreatmentSpasticity1
1Unknown StatusTreatmentThoracic Outlet Syndrome1
1WithdrawnTreatmentBruxism / Myofascial Pain Dysfunction Syndrome, Temporomandibular Joint / Temporomandibular Joint Disorders / Temporomandibular Joint Dysfunction Syndrome1
1WithdrawnTreatmentTorticollis1
1, 2Active Not RecruitingTreatmentModerate to Severe Glabellar Lines1
1, 2CompletedNot AvailableCerebral Palsy (CP)1
1, 2CompletedPreventionAtrial Fibrillation (AF)1
1, 2CompletedTreatmentBenign Prostatic Hyperplasia (BPH)1
1, 2CompletedTreatmentCervical Dystonia / Refractory Cervicothoracic Myofascial Pain Syndrome (CMPS)1
1, 2CompletedTreatmentCluster Headache1
1, 2CompletedTreatmentDetrusor Hyperreflexia / Detrusor Instability / Urinary Bladder, Overactive1
1, 2CompletedTreatmentGlabellar Lines1
1, 2CompletedTreatmentHeadache Disorders / Trigeminal Neuralgia (TN)1
1, 2CompletedTreatmentMigraine Disorders1
1, 2CompletedTreatmentOral Dystonia / Tardive Dystonia1
1, 2CompletedTreatmentOsteoarthritis (OA)1
1, 2CompletedTreatmentRestless Legs Syndrome (RLS)1
1, 2Not Yet RecruitingTreatmentAbnormal Head Position and Neck Pain for These 7 Muscle Groups: Splenius,Scalene,Sterno-cleido-mastoid,Levator Scapulae,Semispinalis,Trapezius,and Longissimus / Cervical Dystonia Adults 1
1, 2Not Yet RecruitingTreatmentChronic Migraine More than15 Days Per Month, and Lasting 4 Hours a Day or Longer1
1, 2Not Yet RecruitingTreatmentIncreased Muscle Tone in Elbow, Wrist, Finger, and Thumb Flexors / Upper Limb Spasticity Unilaterally in Adults With History of Stroke1
1, 2RecruitingTreatmentCleft Lip / Cleft Palates / Scarring1
1, 2RecruitingTreatmentCluster Headache1
1, 2RecruitingTreatmentCompartment Syndrome of Leg1
1, 2TerminatedTreatmentEmpty Nose Syndrome / Rhinitis, Atrophic1
1, 2Unknown StatusTreatmentUrinary Incontinence, Urge1
2Active Not RecruitingTreatmentHallux Abductovalgus1
2Active Not RecruitingTreatmentModerate to Severe Glabellar Frown Lines1
2Active Not RecruitingTreatmentObesity, Morbid1
2Active Not RecruitingTreatmentParkinson's Disease (PD)1
2Active Not RecruitingTreatmentTremor1
2Active Not RecruitingTreatmentTremor, Essential1
2CompletedPreventionMigraine1
2CompletedPreventionPost-operative Excessive Scarring1
2CompletedTreatmentAcne Vulgaris1
2CompletedTreatmentAmyotrophic Lateral Sclerosis (ALS) / Sialorrhea1
2CompletedTreatmentAnal Fissures1
2CompletedTreatmentBMI >30 kg/m21
2CompletedTreatmentBenign Prostatic Hyperplasia (BPH)3
2CompletedTreatmentBlepharospasm1
2CompletedTreatmentBotulinum Toxins, Type A1
2CompletedTreatmentBotulinum Toxin / Cervical Spasm / Radiotherapy Side Effect1
2CompletedTreatmentBotulinum Toxin / Erectile Dysfunction1
2CompletedTreatmentBurning Mouth Syndrome1
2CompletedTreatmentCarpal Tunnel Syndrome (CTS)1
2CompletedTreatmentCerebral Palsy (CP)1
2CompletedTreatmentCerebral Palsy (CP) / Equine and Equinovarus Foot Deformation / Spastic Paraplegia and Hemiparesis1
2CompletedTreatmentCerebral Palsy (CP) / Muscle Spasticity1
2CompletedTreatmentCervical Dystonia2
2CompletedTreatmentCervicogenic Headaches1
2CompletedTreatmentChronic Scar Pain1
2CompletedTreatmentChronic Testicular Pain1
2CompletedTreatmentCrows Feet / Facial Wrinkles / Lateral Canthal Lines4
2CompletedTreatmentCrows Feet / Lateral Canthal Lines3
2CompletedTreatmentCutaneous Leiomyomas / Hereditary Leiomyomatosis and Renal Cell Cancer1
2CompletedTreatmentDementias / Paratonia1
2CompletedTreatmentDepression2
2CompletedTreatmentDetrusor Muscle Hyperactivity1
2CompletedTreatmentDiabetes Mellitus (DM) / Muscle Cramps Aggravated1
2CompletedTreatmentDisease, Chronic / Nasal Polyposis / Rhinitis1
2CompletedTreatmentDysfunctional Voiding1
2CompletedTreatmentEssential Tremor of the Upper Limbs1
2CompletedTreatmentFacial Rhytids1
2CompletedTreatmentGlabellar Frown Lines4
2CompletedTreatmentHyperhidrosis2
2CompletedTreatmentHypertrophy of Masseter Muscle1
2CompletedTreatmentIdiopathic Toe Walking1
2CompletedTreatmentInterstitial Cystitis2
2CompletedTreatmentLacrimation increased1
2CompletedTreatmentLateral Canthal Lines2
2CompletedTreatmentLow Anterior Resection Syndrome / Rectal Carcinoma1
2CompletedTreatmentMajor Depressive Disorder (MDD)1
2CompletedTreatmentMasseter Muscle Hypertrophy / Masticatory Muscles, Hypertrophy of1
2CompletedTreatmentMotor Neurone Disease / Muscle Spasticity / Stroke1
2CompletedTreatmentMuscle Contracture / Muscle Spasticity / Stroke1
2CompletedTreatmentMuscle Spasticity / Stroke2
2CompletedTreatmentMyofascial Pain Syndromes2
2CompletedTreatmentOsteoarthritis (OA)1
2CompletedTreatmentPain of the knee1
2CompletedTreatmentParkinson's Disease (PD)1
2CompletedTreatmentParkinson / Tremor1
2CompletedTreatmentPostherpetic Neuralgia1
2CompletedTreatmentPrimary Axillary Hyperhidrosis1
2CompletedTreatmentProctalgia1
2CompletedTreatmentRaynaud's Phenomenon1
2CompletedTreatmentRestless Legs Syndrome (RLS)1
2CompletedTreatmentRotator Cuff Tear Arthropathy1
2CompletedTreatmentScrotal Pain1
2CompletedTreatmentSialorrhea1
2CompletedTreatmentSkin Aging1
2CompletedTreatmentSkin Quality1
2CompletedTreatmentSmiling1
2CompletedTreatmentSpinal Cord Injuries (SCI)1
2CompletedTreatmentStomach Neoplasms1
2CompletedTreatmentThoracic Outlet Syndrome1
2CompletedTreatmentUrinary Bladder, Overactive4
2CompletedTreatmentUrinary Bladder, Overactive / Urinary Incontinence (UI)1
2CompletedTreatmentFacial fine wrinkling1
2Not Yet RecruitingTreatmentBenign Masseteric Hypertrophy1
2Not Yet RecruitingTreatmentFunctional Popliteal Artery Entrapment Syndrome / Popliteal artery entrapment syndrome1
2Not Yet RecruitingTreatmentJoint Diseases / Knee / Magnetic Resonance Imaging (MRI) / Therapeutics1
2Not Yet RecruitingTreatmentPeripheral Neuropathy Due to Chemotherapy1
2Not Yet RecruitingTreatmentPlantar Fascitis1
2Not Yet RecruitingTreatmentSpastic Foot1
2Not Yet RecruitingTreatmentTemporo-Myofascial Disorder1
2RecruitingSupportive CareEsophageal Carcinoma1
2RecruitingTreatmentAtrial Flutter1
2RecruitingTreatmentBenign Prostatic Hyperplasia (BPH) / Lower Urinary Track Symptoms1
2RecruitingTreatmentBladder Pain Syndrome1
2RecruitingTreatmentBorderline Personality Disorder (BPD)1
2RecruitingTreatmentCervical Dystonia1
2RecruitingTreatmentDisease, Chronic / Migraine Disorders1
2RecruitingTreatmentDystonias1
2RecruitingTreatmentFacial Pain1
2RecruitingTreatmentGlabellar Frown Lines2
2RecruitingTreatmentGroin Injury / Tendinopathy1
2RecruitingTreatmentHyperhidrosis1
2RecruitingTreatmentHypertrophic Scars1
2RecruitingTreatmentLateral Canthal Lines1
2RecruitingTreatmentMasseter Muscle Prominence1
2RecruitingTreatmentMigraine / Migraine Disorders / Pediatrics1
2RecruitingTreatmentNocturnal Bruxism1
2RecruitingTreatmentObstructed Defecation Syndrome (ODS)1
2RecruitingTreatmentOveractive Bladder With Urinary Incontinence / Urinary Incontinence (UI)1
2RecruitingTreatmentPain, Neuropathic1
2RecruitingTreatmentPainful Unilateral Femorotibial Knee Osteoarthritis of Any Etiology1
2RecruitingTreatmentPeyronie's Disease1
2RecruitingTreatmentPlatysma Prominence1
2RecruitingTreatmentPlatysmal Bands1
2RecruitingTreatmentPost Operative Pain1
2RecruitingTreatmentTendinopathy Rotator Cuff1
2RecruitingTreatmentTrigeminal Neuralgia (TN)1
2RecruitingTreatmentVulvodynia1
2TerminatedTreatmentAcne Vulgaris1
2TerminatedTreatmentAllodynia / Pain, Neuropathic1
2TerminatedTreatmentBack Pain Lower Back1
2TerminatedTreatmentBlepharospasm1
2TerminatedTreatmentCerebral Palsy (CP)1
2TerminatedTreatmentCerebral Palsy, Spastic / Pain1
2TerminatedTreatmentHabitual Snoring1
2TerminatedTreatmentNeurogenic Bladder Dysfunction Nos / Spinal Cord Injuries (SCI)1
2TerminatedTreatmentNeuropathic Back Pain / Spinal Cord Injuries (SCI)1
2TerminatedTreatmentNew Daily Persistent Headache1
2TerminatedTreatmentPain1
2TerminatedTreatmentPremature Ejaculation1
2TerminatedTreatmentUrinary Bladder, Overactive2
2Unknown StatusPreventionScarring1
2Unknown StatusTreatmentAcne Rosacea1
2Unknown StatusTreatmentArthritis / Pain1
2Unknown StatusTreatmentEpidermolysis Bullosa Simplex1
2Unknown StatusTreatmentHemifacial Spasm1
2Unknown StatusTreatmentHemiparesis / Shoulder Pain / Stroke1
2WithdrawnTreatmentAmyotrophic Lateral Sclerosis (ALS) / Parkinson's Disease (PD)1
2WithdrawnTreatmentContact Ulcer of Vocal Folds / Granuloma / Granuloma of Vocal Cords / Granuloma, Laryngeal1
2WithdrawnTreatmentLower Urinary Tract Symptoms (LUTS) / Prostate Cancer / Radioactive Seed Implantation1
2WithdrawnTreatmentNeuroma1
2WithdrawnTreatmentSleep-Disordered Breathing1
2WithdrawnTreatmentTraumatic Brain Injury (TBI)1
2WithdrawnTreatmentUrinary Bladder, Overactive / Urinary Incontinence (UI)1
2, 3CompletedPreventionForward Head Posture With Associated Episodic Headache Disorder1
2, 3CompletedPreventionScarring1
2, 3CompletedTreatmentBenign Prostatic Enlargement (BPE) / Benign Prostatic Hyperplasia (BPH)1
2, 3CompletedTreatmentBlepharospasm1
2, 3CompletedTreatmentErectile Dysfunction / Sexual Dysfunctions1
2, 3CompletedTreatmentFowler's Syndrome / Urinary Retention1
2, 3CompletedTreatmentGlabella Line Severity1
2, 3CompletedTreatmentPlantar Fasciitis, Chronic1
2, 3CompletedTreatmentRecalcitrant Alopecia Totalis / Recalcitrant Alopecia Universalis1
2, 3CompletedTreatmentRefractory Migraine1
2, 3CompletedTreatmentSialorrhea1
2, 3Not Yet RecruitingPreventionHypertrophic Scars / Mammary Disorder / Scarring1
2, 3RecruitingTreatmentBase-of-thumb Osteoarthritis1
2, 3RecruitingTreatmentCrows Feet Lines1
2, 3RecruitingTreatmentEpidermolysis Bullosa Simplex1
2, 3RecruitingTreatmentErectile Dysfunction1
2, 3TerminatedTreatmentPrimary Focal Hyperhidrosis of the Hands1
2, 3Unknown StatusTreatmentCerebral Palsy (CP) / Sialorrhea1
2, 3Unknown StatusTreatmentEye Diseases1
2, 3Unknown StatusTreatmentLower Limb Spasticity After Stroke1
2, 3Unknown StatusTreatmentNon-relaxing Puborectalis Syndrome1
2, 3Unknown StatusTreatmentUrinary Bladder, Overactive1
3Active Not RecruitingTreatmentGlabellar Frown Lines1
3Active Not RecruitingTreatmentUrinary Incontinence (UI)1
3CompletedNot AvailableAging1
3CompletedPreventionMigraine Without Aura Prophylaxis1
3CompletedPreventionNeurogenic Bladder Dysfunction1
3CompletedSupportive CareBRCA1 Mutations / BRCA2 Mutation / Breast Cancer / Breast Diseases / Neoplasms / Postoperative pain1
3CompletedSupportive CareStroke With Hemiparesis1
3CompletedTreatmentAllodynia / Headache1
3CompletedTreatmentBack Pain Lower Back1
3CompletedTreatmentBack Pain Lower Back Chronic1
3CompletedTreatmentBilateral Blepharospasm (BEB)1
3CompletedTreatmentBlepharospasm2
3CompletedTreatmentCanthal Lines1
3CompletedTreatmentCerebral Palsy (CP)1
3CompletedTreatmentCerebral Palsy (CP) / Children / Muscle Spasticity2
3CompletedTreatmentCerebral Palsy (CP) / Chronic Troublesome Sialorrhea / Disability, Intellectual / Stroke / Traumatic Brain Injury (TBI)1
3CompletedTreatmentCerebral Palsy (CP) / Muscle Spasticity / Pediatrics2
3CompletedTreatmentCerebral Palsy (CP) / Muscle Spasticity / Pediatrics / Stroke2
3CompletedTreatmentCerebral Palsy (CP) / Post Operative Pain1
3CompletedTreatmentCerebral Palsy (CP) / Spasticity1
3CompletedTreatmentCerebrovascular Accident3
3CompletedTreatmentCervical Dystonia8
3CompletedTreatmentChronic Troublesome Sialorrhea / Parkinson's Disease (PD) / Post-stroke / Traumatic Brain Injury (TBI)1
3CompletedTreatmentComparison between group treated with botulinum toxin and placebo1
3CompletedTreatmentCrow's Feet Lines1
3CompletedTreatmentCrow's Feet Lines / Facial Rhytides / Glabellar Lines2
3CompletedTreatmentCrow's Feet Lines / Frown Lines / Glabellar Lines / Upper Facial Rhytides1
3CompletedTreatmentCrow's Feet Lines / Lateral Canthal Lines1
3CompletedTreatmentCrow's Feet Lines / Lateral Canthus Rhytides2
3CompletedTreatmentDisseminated Sclerosis / Neurogenic Bladder Dysfunction / Urinary Incontinence (UI)1
3CompletedTreatmentDisseminated Sclerosis / Tremor1
3CompletedTreatmentEpicondylitis, Lateral Humeral1
3CompletedTreatmentEssential Blepharospasm2
3CompletedTreatmentFacial Rhytides / Glabellar Rhytides1
3CompletedTreatmentForehead Rhytides / Glabellar Rhytides1
3CompletedTreatmentFrown Lines Between the Eyebrows / Glabellar Rhytides1
3CompletedTreatmentGlabellar Frown Lines5
3CompletedTreatmentGlabellar Lines5
3CompletedTreatmentGlabellar Lines / Moderate to Severe Glabellar Lines1
3CompletedTreatmentGlabellar Rhytides2
3CompletedTreatmentHealthy Volunteers1
3CompletedTreatmentHemifacial Spasm1
3CompletedTreatmentHyperhidrosis1
3CompletedTreatmentLateral Epicondylitis2
3CompletedTreatmentLateral Periorbital Wrinkles1
3CompletedTreatmentLeg Spasticity1
3CompletedTreatmentLower Extremity Deformities, Congenital / Unequal Length of Limbs; Congenital1
3CompletedTreatmentLower Limb Spasticity Due to Cerebral Palsy1
3CompletedTreatmentLower Limb and Combined Lower Limb and Upper Limb Spasticity Due to Cerebral Palsy1
3CompletedTreatmentMigraine Disorders3
3CompletedTreatmentModerate to Severe Glabellar Frown Lines2
3CompletedTreatmentModerate to Severe Glabellar Line1
3CompletedTreatmentMuscle Spasticity2
3CompletedTreatmentMyofascial Pain Syndromes1
3CompletedTreatmentMyofascial Pelviperineal Pain1
3CompletedTreatmentNervous System Disorders2
3CompletedTreatmentNeurogenic Detrusor Overactivity1
3CompletedTreatmentNeurogenic Vesical Hyperactivity Syndrom1
3CompletedTreatmentNotalgia Paresthetica1
3CompletedTreatmentOther Infantile Cerebral Palsy1
3CompletedTreatmentPost-stroke Spasticity of the Lower Limb1
3CompletedTreatmentPost-stroke Spasticity of the Upper Limb1
3CompletedTreatmentPost-stroke Upper Limb Spasticity1
3CompletedTreatmentRaynaud's Phenomenon / Scleroderma1
3CompletedTreatmentRefractory Urge Urinary Incontinence / Urinary Incontinence, Urge1
3CompletedTreatmentSkin Aging5
3CompletedTreatmentSpastic Diplegic Cerebral Palsy1
3CompletedTreatmentSpasticity2
3CompletedTreatmentSpasticity Post-Traumatic Brain Injury / Spasticity, Post-Stroke1
3CompletedTreatmentSpasticity of the Upper and Lower Limb Due to Cerebral Causes1
3CompletedTreatmentSpasticity, Post-Stroke2
3CompletedTreatmentSpasticity / Stroke2
3CompletedTreatmentStrabismus1
3CompletedTreatmentStroke1
3CompletedTreatmentUpper Limb Spasticity1
3CompletedTreatmentUpper Limb Spasticity (Altered Skeletal Muscle Performance) in Children1
3CompletedTreatmentUrinary Bladder, Overactive6
3CompletedTreatmentUrinary Bladder, Overactive / Urinary Incontinence (UI)2
3CompletedTreatmentUrinary Bladder, Overactive / Urinary Incontinence, Urge1
3CompletedTreatmentUrinary Incontinence (UI)1
3CompletedTreatmentVulvodynia2
3CompletedTreatmentFacial fine wrinkling1
3Enrolling by InvitationTreatmentChronic Migraine1
3Enrolling by InvitationTreatmentUrinary Bladder, Overactive1
3Not Yet RecruitingTreatmentCerebral Palsy (CP)1
3Not Yet RecruitingTreatmentCerebrovascular Accident1
3Not Yet RecruitingTreatmentExcessive Gingival Display1
3Not Yet RecruitingTreatmentTrigeminal Neuropathy, Traumatic1
3Not Yet RecruitingTreatmentUrinary Incontinence, Urge / Urinary Incontinence,Stress1
3RecruitingPreventionIntercanthal Distance Ratio / Scarring1
3RecruitingTreatmentAcquired Esotropia1
3RecruitingTreatmentCerebral Palsy (CP)3
3RecruitingTreatmentCerebrovascular Accident1
3RecruitingTreatmentCervical Dystonia1
3RecruitingTreatmentCluster Headache1
3RecruitingTreatmentCrow's Feet Lines2
3RecruitingTreatmentDisseminated Sclerosis / Spasticity, Muscle1
3RecruitingTreatmentEssential Head Tremor1
3RecruitingTreatmentFecal Incontinence1
3RecruitingTreatmentFocal Hand Dystonia1
3RecruitingTreatmentGlabellar Frown Lines3
3RecruitingTreatmentHyperhidrosis Primary Focal Axilla1
3RecruitingTreatmentHyperhidrosis / Residual Limbs1
3RecruitingTreatmentLateral Epicondylitis1
3RecruitingTreatmentLower Limb or Combined Lower Limb and Upper Limb Spasticity Due to Stroke or Traumatic Brain Injury1
3RecruitingTreatmentMasseter Muscle Prominence1
3RecruitingTreatmentMigraine Disorders1
3RecruitingTreatmentMyofascial Pain Syndrome / Pain Syndrome / Pain, Head / Temporomandibular Disorders1
3RecruitingTreatmentObstetrical Brachial Plexus Palsy1
3RecruitingTreatmentRaynaud Phenomenon Secondary to Systemic Sclerosis1
3RecruitingTreatmentStroke1
3RecruitingTreatmentSurgery, Cardiac1
3RecruitingTreatmentTrigeminal Neuralgia (TN)1
3RecruitingTreatmentUrinary Bladder, Overactive1
3RecruitingTreatmentUrinary Bladder, Overactive / Urinary Incontinence (UI)1
3RecruitingTreatmentVestibulodynia1
3TerminatedTreatmentChronic Post Traumatic Headache1
3TerminatedTreatmentChronic Prostatitis With Chronic Pelvic Pain Syndrome / Prostatitis1
3TerminatedTreatmentDetrusor Hyperreflexia / Urinary Bladder, Overactive / Urinary Incontinence (UI) / Urinary Incontinence, Urge / Urinary Urge Incontinence1
3TerminatedTreatmentDetrusor Overactivity / Urinary Incontinence (UI) / Urinary Incontinence, Urge / Urinary Urgency1
3TerminatedTreatmentLower Urinary Tract Discomfort / Stent Pain1
3TerminatedTreatmentMuscle Spasticity / Stroke1
3TerminatedTreatmentPatellofemoral Pain Syndrome1
3TerminatedTreatmentSkin Aging1
3TerminatedTreatmentUrinary Bladder, Overactive1
3TerminatedTreatmentUrinary Bladder, Overactive / Urinary Incontinence (UI)2
3Unknown StatusTreatmentArthritis / Shoulder Pain1
3Unknown StatusTreatmentFoot Dystonia / Parkinson's Disease (PD)1
3Unknown StatusTreatmentHemiplegic Patients Post-AVC1
3Unknown StatusTreatmentScarring1
3Unknown StatusTreatmentVaginismus1
3Unknown StatusTreatmentFacial fine wrinkling1
3WithdrawnOtherNeuralgia / Pain Due to Certain Specified Procedures / Pain, Neuropathic1
3WithdrawnPreventionMigraine Disorders2
3WithdrawnTreatmentMuscle Spasticity / Stroke1
4Active Not RecruitingOtherGlabellar Frown Lines1
4Active Not RecruitingTreatmentChronic Idiopathic Constipation / Functional Constipation1
4Active Not RecruitingTreatmentMixed Urinary Incontinence / Stress Urinary Incontinence (SUI) / Urgency Incontinence1
4Active Not RecruitingTreatmentPainful Intercourse / Pelvic Floor Dysfunctions / Pelvic Pain1
4Active Not RecruitingTreatmentParkinson's Disease (PD)1
4Active Not RecruitingTreatmentSpinal Cord Injuries (SCI) / Urinary Bladder, Overactive1
4Active Not RecruitingTreatmentUrinary Bladder, Overactive1
4CompletedNot AvailableHealthy Subjects, Only With Wrinkles on Forehead1
4CompletedNot AvailableUrinary Bladder, Overactive1
4CompletedBasic ScienceHealthy Volunteers1
4CompletedPreventionMigraine Disorders2
4CompletedPreventionPainful Bladder Syndrome (PBS) / Urinary Bladder, Neurogenic / Urinary Bladder, Overactive / Urinary Urge Incontinence1
4CompletedTreatmentAesthetics1
4CompletedTreatmentAging1
4CompletedTreatmentBlepharoptosis / Brow Ptosis1
4CompletedTreatmentBlepharospasm1
4CompletedTreatmentBlepharospasm / Botulinum Toxins, Type A / Hemifacial Spasm1
4CompletedTreatmentBrain Injury / Spasticity Secondary to Either a Disorder or Trauma / Spinal Cord Injuries (SCI) / Stroke / Tumors1
4CompletedTreatmentBrain Injury / Spasticity / Stroke1
4CompletedTreatmentBrow Ptosis1
4CompletedTreatmentCerebral Palsy (CP)1
4CompletedTreatmentCerebral Palsy and Botulinum Toxin1
4CompletedTreatmentCerebrovascular Accident / Muscle Spasticity2
4CompletedTreatmentCervical Dystonia5
4CompletedTreatmentChronic Migraine5
4CompletedTreatmentClostridium Botulinum Toxin Adverse Reaction / Neurogenic Bladder Dysfunction / Parkinson's Disease (PD) / Urinary Incontinence (UI)1
4CompletedTreatmentCrow's Feet Lines / Facial Rhytides / Glabellar Lines / Nasolabial Folds1
4CompletedTreatmentDepression / Quality of Life1
4CompletedTreatmentDiabetic Polyneuropathies / Other Polyneuropathies / Postherpetic Neuralgia1
4CompletedTreatmentDisseminated Sclerosis / Muscle Spasticity1
4CompletedTreatmentEsotropia / Exotropia1
4CompletedTreatmentEssential Blepharospasm2
4CompletedTreatmentFacial Asymmetry / Facial Nerve Injuries / Facial Paresis Associated With Facial Nerve Dysfunction / Synkinesis1
4CompletedTreatmentFacial Rhytides1
4CompletedTreatmentFibromyalgia1
4CompletedTreatmentGlabellar Frown Lines3
4CompletedTreatmentGlabellar Furrows1
4CompletedTreatmentGlabellar Lines1
4CompletedTreatmentGlabellar Rhytides1
4CompletedTreatmentHallux Valgus1
4CompletedTreatmentHyperhidrosis3
4CompletedTreatmentInterstitial Cystitis1
4CompletedTreatmentInterstitial Cystitis / Painful Bladder Syndrome (PBS)1
4CompletedTreatmentIntrinsic Aging of Skin / Solar Elastosis1
4CompletedTreatmentMigraine Disorders2
4CompletedTreatmentMild to Moderate Temporal Atrophy / Moderate to Severe Glabellar Rhytids / Moderate to Severe Periorbital Rhytids1
4CompletedTreatmentMuscle Spasticity2
4CompletedTreatmentMuscle Spasticity / Stroke1
4CompletedTreatmentNerve Trauma / Postherpetic Neuralgia1
4CompletedTreatmentPain, Neuropathic / Spinal Cord Injuries (SCI)1
4CompletedTreatmentPain / Spinal Cord Injuries (SCI)1
4CompletedTreatmentPlantar Fascitis1
4CompletedTreatmentPost-Traumatic Headaches1
4CompletedTreatmentSkin Aging1
4CompletedTreatmentSpasmodic Torticollis1
4CompletedTreatmentSpastic Hemiplegia1
4CompletedTreatmentSpastic Hemiplegia / Spasticity as Sequela of Stroke / Stroke1
4CompletedTreatmentSpasticity1
4CompletedTreatmentStroke Rehabilitation / Stroke Rehabilitation Spasticity Management1
4CompletedTreatmentStroke / Upper Limb Spasticity1
4CompletedTreatmentSun-induced Wrinkles1
4CompletedTreatmentTorticollis1
4CompletedTreatmentUpper Limb Spasticity1
4CompletedTreatmentUrinary Bladder, Overactive1
4CompletedTreatmentUrinary Bladder, Overactive / Urinary Incontinence (UI)2
4CompletedTreatmentVitiligo1
4CompletedTreatmentWrinkles in Frontal Area2
4CompletedTreatmentFacial fine wrinkling1
4Enrolling by InvitationOtherForehead Rhytides / Forehead Wrinkles1
4Enrolling by InvitationTreatmentAchalasia1
4Enrolling by InvitationTreatmentPost Operative Nausea and Vomiting (PONV) / Post-gastrointestinal bypass surgery1
4Not Yet RecruitingTreatmentActivity / Pain1
4Not Yet RecruitingTreatmentAdolescent Idiopathic Scoliosis (AIS)1
4Not Yet RecruitingTreatmentObese / Type 2 Diabetes Mellitus1
4Not Yet RecruitingTreatmentPain / Stroke1
4Not Yet RecruitingTreatmentSpastic Hemiplegia / Stroke Sequelae1
4RecruitingBasic ScienceMigraine1
4RecruitingOtherMuscle Spasticity / Stroke1
4RecruitingPreventionOther Degenerative Disorders of Eyelid and Periocular Area1
4RecruitingTreatmentBreast Diseases / Neoplasms / Neoplasms by Site / Neoplasms, Breast / Skin Diseases1
4RecruitingTreatmentBrow Lifting1
4RecruitingTreatmentCerebral Palsy (CP) / Muscle Spasticity1
4RecruitingTreatmentEquinovarus; Acquired1
4RecruitingTreatmentFacial Rhytides, Skin Folds, Loss of Volume and Skin Quality1
4RecruitingTreatmentFissure in Ano1
4RecruitingTreatmentHypertrophic Scars / Scar Keloid1
4RecruitingTreatmentKnee Osteoarthritis (Knee OA)1
4RecruitingTreatmentMuscle Spasticity / Stroke1
4RecruitingTreatmentPain, Face1
4RecruitingTreatmentRaynaud's Phenomenon1
4RecruitingTreatmentScarring1
4RecruitingTreatmentSpasticity1
4RecruitingTreatmentSpasticity as Sequela of Stroke1
4RecruitingTreatmentSpasticity / Stroke1
4RecruitingTreatmentSynkinesis1
4RecruitingTreatmentUrinary Bladder, Overactive1
4RecruitingTreatmentUrinary Bladder, Overactive / Urinary Frequency/Urgency / Urinary Incontinence (UI) / Urinary Urgency1
4TerminatedTreatmentAnxiety / Anxiety Disorder Social1
4TerminatedTreatmentArthritis Multiple Joint / Basal Thumb Joint Arthritis / Basilar Joint Arthritis / Carpometacarpal Arthritis / Trapeziometacarpal Arthritis1
4TerminatedTreatmentBack Pain Lower Back1
4TerminatedTreatmentChronic Male Pelvic Pain Syndrome1
4TerminatedTreatmentEssential Axillary Hyperhidrosis1
4TerminatedTreatmentParkinson's Disease (PD)1
4TerminatedTreatmentSpasmodic Torticollis1
4Unknown StatusPreventionAutonomic Dysreflexia1
4Unknown StatusTreatmentBack Pain Lower Back Chronic1
4Unknown StatusTreatmentBotulinum Toxin / Cervical Dystonia / Quality of Life1
4Unknown StatusTreatmentBruxism1
4Unknown StatusTreatmentCatocholamine Induced Finger Necrosis1
4Unknown StatusTreatmentElastosis Senilis / Skin Aging1
4Unknown StatusTreatmentMajor Depressive Disorder (MDD)1
4Unknown StatusTreatmentOveractive Detrusor1
4Unknown StatusTreatmentSleep Bruxism1
4WithdrawnTreatmentFoot Deformities / Leg Length Inequality1
4WithdrawnTreatmentGraves Ophthalmopathy1
Not AvailableActive Not RecruitingNot AvailableLower Limb Spasticity1
Not AvailableActive Not RecruitingNot AvailableUrinary Bladder, Overactive1
Not AvailableActive Not RecruitingTreatmentFlushing1
Not AvailableActive Not RecruitingTreatmentHeadache1
Not AvailableActive Not RecruitingTreatmentIdiopathic Clubfoot (Talipes Equinovarus)1
Not AvailableActive Not RecruitingTreatmentMyofascial Pelvic Pain1
Not AvailableActive Not RecruitingTreatmentFacial fine wrinkling1
Not AvailableCompletedNot AvailableBlepharospasm / Cervical Dystonia1
Not AvailableCompletedNot AvailableCerebral Palsy (CP)3
Not AvailableCompletedNot AvailableCervical Dystonia1
Not AvailableCompletedNot AvailableCervical Dystonia / Torticollis1
Not AvailableCompletedNot AvailableChronic Migraine1
Not AvailableCompletedNot AvailableCrow's Feet Lines / Lateral Canthal Lines1
Not AvailableCompletedNot AvailableFacial Rhytides1
Not AvailableCompletedNot AvailableGlabellar Lines1
Not AvailableCompletedNot AvailableGlabellar Lines / Hyperhidrosis / Muscle Spasticity1
Not AvailableCompletedNot AvailableHeadache / Migraine Disorders1
Not AvailableCompletedNot AvailableLower Limb Spasticity1
Not AvailableCompletedNot AvailableMigraine Disorders2
Not AvailableCompletedNot AvailableMumps1
Not AvailableCompletedNot AvailableMuscle Spasticity2
Not AvailableCompletedNot AvailableNeurogenic Bladder Dysfunction2
Not AvailableCompletedNot AvailableRefractory Chronic Migraine1
Not AvailableCompletedNot AvailableSkin Laxity1
Not AvailableCompletedNot AvailableSpasticity, Post-Stroke1
Not AvailableCompletedNot AvailableTorticollis1
Not AvailableCompletedNot AvailableUrinary Bladder, Neurogenic / Urinary Bladder, Overactive1
Not AvailableCompletedNot AvailableUrinary Bladder, Overactive / Urinary Incontinence (UI)3
Not AvailableCompletedNot AvailableUrinary Incontinence (UI)1
Not AvailableCompletedDiagnosticBotulinum Toxins, Type A / Normal, Healthy Volunteers / Strength, Muscle1
Not AvailableCompletedHealth Services ResearchHealthy Volunteers1
Not AvailableCompletedHealth Services ResearchMuscle Spasticity / Stroke1
Not AvailableCompletedPreventionHerpes Labialis1
Not AvailableCompletedPreventionPost Traumatic Stiffness1
Not AvailableCompletedSupportive CarePain1
Not AvailableCompletedTreatmentAchalasia, Esophageal1
Not AvailableCompletedTreatmentAlopecia Areata (AA)1
Not AvailableCompletedTreatmentAnkle Osteoarthritis1
Not AvailableCompletedTreatmentAnticholinergic Syndrome / Quality of Life / Urinary Bladder, Overactive / Urologic Diseases1
Not AvailableCompletedTreatmentAxillary Hyperhidrosis1
Not AvailableCompletedTreatmentBotulinum Toxin / Cerebral Palsy, Spastic / Physical Therapy1
Not AvailableCompletedTreatmentCerebral Palsy (CP) / Muscle Spasticity1
Not AvailableCompletedTreatmentDiabetes Mellitus (DM) / Pain, Neuropathic1
Not AvailableCompletedTreatmentDiabetes Mellitus (DM) / Peripheral neuropathy / Plantar Ulcers1
Not AvailableCompletedTreatmentEpicondylitis, Lateral Humeral / Lateral Epicondylitis1
Not AvailableCompletedTreatmentFacial Paralysis1
Not AvailableCompletedTreatmentFacial Rhytides / Glabellar Frown Lines1
Not AvailableCompletedTreatmentFacial Wrinkles1
Not AvailableCompletedTreatmentGastroparesis1
Not AvailableCompletedTreatmentHIV Posterior Cheek Enlargement1
Not AvailableCompletedTreatmentHyperhidrosis1
Not AvailableCompletedTreatmentIdiopathic Clubfoot (Talipes Equinovarus)1
Not AvailableCompletedTreatmentIdiopathic Toe-walking1
Not AvailableCompletedTreatmentKeratoconus1
Not AvailableCompletedTreatmentMyofascial Pain Syndrome / Temporomandibular Disorders1
Not AvailableCompletedTreatmentNon-neurogenic / Urinary Urge Incontinence1
Not AvailableCompletedTreatmentPain1
Not AvailableCompletedTreatmentPelvic Pain1
Not AvailableCompletedTreatmentPost-stroke Shoulder Pain and Spasticity1
Not AvailableCompletedTreatmentPost-stroke Upper Limb Spasticity1
Not AvailableCompletedTreatmentPrimary Axillary Hyperhidrosis1
Not AvailableCompletedTreatmentRaynaud's Phenomenon1
Not AvailableCompletedTreatmentSkin Wrinklings1
Not AvailableCompletedTreatmentSpastic Equinovarus1
Not AvailableCompletedTreatmentSpasticity, Muscle1
Not AvailableCompletedTreatmentSpinal Cord Injuries (SCI)1
Not AvailableCompletedTreatmentSpinal Stenosis With Nocturnal Calf Cramps1
Not AvailableCompletedTreatmentSubacute Cervical Pain / Subacute Upper Back Pain1
Not AvailableCompletedTreatmentTremor, Essential1
Not AvailableCompletedTreatmentUpper Limb Spasticity1
Not AvailableCompletedTreatmentUrinary Incontinence (UI)1
Not AvailableCompletedTreatmentVaginismus1
Not AvailableEnrolling by InvitationNot AvailableUnilateral Spastic Cerebral Palsy1
Not AvailableNot Yet RecruitingTreatmentOsteoarthritis Knees Both1
Not AvailableRecruitingNot AvailableDetrusor, Overactive / Disseminated Sclerosis / Lower Urinary Tract Symptoms (LUTS) / Neurogenic Bladder Dysfunction / Urinary Incontinence, Urge1
Not AvailableRecruitingNot AvailableDysphonia1
Not AvailableRecruitingNot AvailableEsthetic Outcome of Injection of Botulinum Toxin Type-A in Cleft Lip Repair1
Not AvailableRecruitingNot AvailableMixed Incontinence, Urge and Stress1
Not AvailableRecruitingNot AvailableMuscle Spasticity1
Not AvailableRecruitingNot AvailableUrinary Bladder, Overactive1
Not AvailableRecruitingTreatmentChronic Vocal Tic / Gilles de la Tourette's Syndrome1
Not AvailableRecruitingTreatmentEpicondylitis, Lateral Humeral / Lateral Epicondylitis1
Not AvailableRecruitingTreatmentHemifacial Spasm1
Not AvailableRecruitingTreatmentMigraine1
Not AvailableRecruitingTreatmentPlantar fascial fibromatosis1
Not AvailableSuspendedTreatmentPain1
Not AvailableTerminatedNot AvailableCerebral Palsy (CP)1
Not AvailableTerminatedTreatmentBrain Injury / Stiff Knee Gait1
Not AvailableTerminatedTreatmentEquinus Contracture1
Not AvailableTerminatedTreatmentErythema and Flushing Associated With Rosacea1
Not AvailableTerminatedTreatmentIschaemia / Vasopressor1
Not AvailableTerminatedTreatmentMigraine1
Not AvailableTerminatedTreatmentUrinary Bladder, Overactive1
Not AvailableUnknown StatusTreatmentAlopecia Areata (AA)1
Not AvailableUnknown StatusTreatmentBlepharospasm1
Not AvailableUnknown StatusTreatmentCerebral Palsy (CP) / Drooling1
Not AvailableUnknown StatusTreatmentEsophageal Spasm, Diffuse1
Not AvailableUnknown StatusTreatmentFlexion Contracture Following Total Knee Replacement1
Not AvailableUnknown StatusTreatmentLateral Epicondylitis / Type A Botulinum Toxin1
Not AvailableWithdrawnNot AvailableChronic Migraine1
Not AvailableWithdrawnTreatmentGingival Exposure1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
  • Allergan Inc.
  • Tercica Inc.
Dosage forms
FormRouteStrength
Injection, powder, lyophilized, for solutionIntradermal; Intramuscular100 [USP'U]/1
Injection, powder, lyophilized, for solutionIntradermal; Intramuscular200 [USP'U]/1
Powder, for solutionIntramuscular100 unit
Injection, powder, lyophilized, for solutionIntramuscular300 U/1
Injection, powder, lyophilized, for solutionIntramuscular300 [USP'U]/1
Injection, powder, lyophilized, for solutionIntramuscular500 U/1
PowderIntramuscular100 [USP'U]/1
Injection, powder, lyophilized, for solutionIntramuscular100 [USP'U]/1
Injection, powder, lyophilized, for solutionIntramuscular200 [USP'U]/1
Injection, powder, lyophilized, for solutionIntramuscular50 [USP'U]/1
Powder, for solutionIntramuscular50 unit
Powder, for solutionIntramuscular
Prices
Unit descriptionCostUnit
Botox 200 unit vial1260.0USD vial
Dysport 500 unit vial852.0USD vial
Botox 100 unit655.2USD vial
Botox 100 unit vial630.0USD vial
Botox cosmetic 100 unit vial630.0USD vial
Botox cosmetic 50 unit vial346.8USD vial
Botox (100 - 200 unit/Vial)3.74USD vial
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2280565No2005-11-152019-08-20Canada
CA2310845No2001-05-152014-06-07Canada
Additional Data Available
  • Filed On
    Filed On

    The date on which a patent was filed with the relevant government.

    Learn more

Properties

State
Solid
Experimental Properties
PropertyValueSource
water solubilitySolubleNot Available
hydrophobicity-0.368Not Available
isoelectric point6.06Not Available

Taxonomy

Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available

Targets

Kind
Protein
Organism
Humans
Pharmacological action
Yes
Actions
Inhibitor
General Function
Syntaxin-1 binding
Specific Function
t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesi...
Gene Name
SNAP25
Uniprot ID
P60880
Uniprot Name
Synaptosomal-associated protein 25
Molecular Weight
23314.905 Da
References
  1. Zhou JY, Wang ZF, Ren XM, Tang MZ, Shi YL: Antagonism of botulinum toxin type A-induced cleavage of SNAP-25 in rat cerebral synaptosome by toosendanin. FEBS Lett. 2003 Dec 4;555(2):375-9. [PubMed:14644446]
  2. Flynn TC: Myobloc. Dermatol Clin. 2004 Apr;22(2):207-11, vii. [PubMed:15222581]
  3. Okada M, Yoshida S, Zhu G, Kaneko S: [Methodological consideration in studying the exocytosis mechanisms using microdialysis]. Nihon Shinkei Seishin Yakurigaku Zasshi. 2004 Aug;24(4):165-70. [PubMed:15484814]
  4. Frassoni C, Inverardi F, Coco S, Ortino B, Grumelli C, Pozzi D, Verderio C, Matteoli M: Analysis of SNAP-25 immunoreactivity in hippocampal inhibitory neurons during development in culture and in situ. Neuroscience. 2005;131(4):813-23. [PubMed:15749336]
  5. Straughan D: Progress in applying the Three Rs to the potency testing of Botulinum toxin type A. Altern Lab Anim. 2006 Jun;34(3):305-13. [PubMed:16831062]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Gtpase activity
Specific Function
Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative r...
Gene Name
RHOB
Uniprot ID
P62745
Uniprot Name
Rho-related GTP-binding protein RhoB
Molecular Weight
22123.185 Da
References
  1. Ishida H, Zhang X, Erickson K, Ray P: Botulinum toxin type A targets RhoB to inhibit lysophosphatidic acid-stimulated actin reorganization and acetylcholine release in nerve growth factor-treated PC12 cells. J Pharmacol Exp Ther. 2004 Sep;310(3):881-9. Epub 2004 May 12. [PubMed:15140914]

Drug created on June 13, 2005 07:24 / Updated on December 08, 2019 20:10