Salicylates

The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.
DrugDrug NameDrug Indication
DB00936Salicylic acidKey additive in many skin-care products for the treatment of acne, psoriasis, callouses, corns, keratosis pilaris and warts.
DB00945Acetylsalicylic acid**Pain, fever, and inflammation** Acetylsalicylic acid (ASA), in the regular tablet form (immediate-release), is indicated to relieve pain, fever, and inflammation associated with many conditions, including the flu, the common cold, neck and back pain, dysmenorrhea, headache, tooth pain, sprains, fractures, myositis, neuralgia, synovitis, arthritis, bursitis, burns, and various injuries. It is also used for symptomatic pain relief after surgical and dental procedures [FDA label]. The _extra strength_ formulation of acetylsalicylic acid is also indicated for the management migraine pain with photophobia (sensitivity to light) and phonophobia (sensitivity to sound)[FDA label]. **Other indications** ASA is also indicated for various other purposes, due to its ability to inhibit platelet aggregation. These include: Reducing the risk of cardiovascular death in suspected cases of myocardial infarction (MI) [FDA label]. Reducing the risk of a first non-fatal myocardial infarction in patients, and for reducing the risk of morbidity and mortality in cases of unstable angina and in those who have had a prior myocardial infarction [FDA label]. For reducing the risk of transient ischemic attacks (TIA) and to prevent atherothrombotic cerebral infarction (in conjunction with other treatments) [FDA label]. For the prevention of thromboembolism after hip replacement surgery [FDA label]. For decreasing platelet to platelet adhesion following carotid endarterectomy, aiding in the prevention of transient ischemic attacks (TIA) [FDA label]. Used for patients undergoing hemodialysis with a silicone rubber arteriovenous cannula inserted to prevent thrombosis at the insertion site [FDA Label]. **Important note regarding use of the extended-release formulation [F4405]** In the setting of acute myocardial infarction, or before percutaneous interventions, the extended-release form of acetylsalicylic acid should not be used. Use immediate-release formulations in scenarios requiring rapid onset of action [Label, F4405]. The extended-release form is taken to decrease the incidence of mortality and myocardial infarction (MI) for individuals diagnosed with chronic coronary artery disease (CAD), including patients with previous myocardial infarction (MI) or unstable angina or with chronic stable angina. Additionally, the extended-release form is used to decrease the risk of death and recurrent episodes of stroke in patients with a history of stroke or TIA [F4405].
DB00244MesalazineMesalazine is indicated for the induction of remission in patients with active or mild to moderate acute exacerbations of ulcerative colitis and for the maintenance of remission of ulcerative colitis [FDA Label], [L5101]. Prescribing information for mesalazine in the UK also indicates the medication for the maintenance of remission of Crohn's ileo-colitis [L5101].
DB01014BalsalazideFor the treatment of mildly to moderately active ulcerative colitis.
DB01250OlsalazineFor the treatment of Inflammatory Bowel Disease and Ulcerative Colitis.
DB00795SulfasalazineFor the treatment of Crohn's disease and rheumatoid arthritis as a second-line agent.
DB00233Aminosalicylic AcidFor the treatment of tuberculosis
DB00861DiflunisalFor symptomatic treatment of mild to moderate pain accompanied by inflammation (e.g. musculoskeletal trauma, post-dental extraction, post-episiotomy), osteoarthritis, and rheumatoid arthritis.
DB06251DersalazineInvestigated for use/treatment in inflammatory bowel disease.
DB06807Phenyl aminosalicylateNot Available
DB12445NitroaspirinNot Available
DB13509AloxiprinNot Available
DB13538GuacetisalNot Available
DB13612Carbaspirin calciumNot Available
DB09543Methyl salicylateOintments or liniments containing methyl salicylate are applied topically as counter irritant for relief of acute pain associated with lumbago,sciatica and rheumatic conditions. Local analgesics for human and veterinary medicine.
DB11079Trolamine salicylateIndicated for the temporary relief of aches, and pains of muscles and joints associated with backache, lumbago, strains, bruises, sprains and arthritic or rheumatic pain, pain of tendons and ligaments [L1791].
DB01294Bismuth subsalicylateUsed to treat nausea, heartburn, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract.
DB14026Thiosalicylic acidNot Available
DB14006Choline salicylateThe oral gel is indicated for the relief of pain and discomfort of common mouth ulcers, cold sores, denture sore spots, infant teething and mouth ulcers, and sore spots due to orthodontic devices in children [L2135].
DrugDrug NameTargetType
DB00936Salicylic acidSerum albumincarrier
DB00936Salicylic acidProstaglandin G/H synthase 1target
DB00936Salicylic acidProstaglandin G/H synthase 2target
DB00936Salicylic acidAldo-keto reductase family 1 member C1target
DB00936Salicylic acidSolute carrier family 22 member 6transporter
DB00936Salicylic acidSolute carrier family 22 member 10transporter
DB00936Salicylic acidSolute carrier family 22 member 8transporter
DB00936Salicylic acidSolute carrier family 22 member 11transporter
DB00936Salicylic acidSolute carrier organic anion transporter family member 2B1transporter
DB00936Salicylic acidMonocarboxylate transporter 1transporter
DB00936Salicylic acidSolute carrier family 22 member 7transporter
DB00936Salicylic acidCytochrome P450 2C9enzyme
DB00945Acetylsalicylic acidProstaglandin G/H synthase 1target
DB00945Acetylsalicylic acidProstaglandin G/H synthase 2target
DB00945Acetylsalicylic acidAldo-keto reductase family 1 member C1target
DB00945Acetylsalicylic acidSolute carrier family 22 member 6transporter
DB00945Acetylsalicylic acidMultidrug resistance protein 1transporter
DB00945Acetylsalicylic acidCytochrome P450 2C19enzyme
DB00945Acetylsalicylic acidCytochrome P450 2C9enzyme
DB00945Acetylsalicylic acid5'-AMP-activated protein kinasetarget
DB00945Acetylsalicylic acidEndothelin-1 receptortarget
DB00945Acetylsalicylic acidNuclear factor kappa b beta subunittarget
DB00945Acetylsalicylic acidCellular tumor antigen p53target
DB00945Acetylsalicylic acid78 kDa glucose-regulated proteintarget
DB00945Acetylsalicylic acidRibosomal protein S6 kinase alpha-3target
DB00945Acetylsalicylic acidNF-kappa-B inhibitor alphatarget
DB00945Acetylsalicylic acidTumor necrosis factor-inducible gene 6 proteintarget
DB00945Acetylsalicylic acidCaspase-1target
DB00945Acetylsalicylic acidCaspase-3target
DB00945Acetylsalicylic acidInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB00945Acetylsalicylic acidExtracellular signal-regulated kinase (ERK)target
DB00945Acetylsalicylic acidG1/S-specific cyclin-D1target
DB00945Acetylsalicylic acidMyc proto-oncogene proteintarget
DB00945Acetylsalicylic acidProliferating cell nuclear antigentarget
DB00945Acetylsalicylic acidCyclin Atarget
DB00945Acetylsalicylic acidUDP-glucuronosyltransferase 1-6enzyme
DB00945Acetylsalicylic acidArylamine N-acetyltransferase 2enzyme
DB00945Acetylsalicylic acidSolute carrier family 22 member 8transporter
DB00244MesalazineProstaglandin G/H synthase 1target
DB00244MesalazineProstaglandin G/H synthase 2target
DB00244MesalazinePeroxisome proliferator-activated receptor gammatarget
DB00244MesalazineInhibitor of nuclear factor kappa-B kinase subunit alphatarget
DB00244MesalazineInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB00244MesalazineArachidonate 5-lipoxygenasetarget
DB00244MesalazineMyeloperoxidasetarget
DB00244MesalazineArylamine N-acetyltransferasetarget
DB00244MesalazineArylamine N-acetyltransferase 1enzyme
DB01014BalsalazideProstaglandin G/H synthase 1target
DB01014BalsalazideProstaglandin G/H synthase 2target
DB01014BalsalazideArachidonate 5-lipoxygenasetarget
DB01014BalsalazidePeroxisome proliferator-activated receptor gammatarget
DB01014BalsalazideNADPH azoreductaseenzyme
DB01250OlsalazineInterferon gammatarget
DB01250OlsalazineThiopurine S-methyltransferasetarget
DB00795SulfasalazineAcetyl-CoA acetyltransferase, mitochondrialtarget
DB00795SulfasalazineCystine/glutamate transportertarget
DB00795SulfasalazineATP-binding cassette sub-family G member 2transporter
DB00795SulfasalazineCanalicular multispecific organic anion transporter 1transporter
DB00795SulfasalazineInhibitor of nuclear factor kappa-B kinase subunit alphatarget
DB00795SulfasalazineInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB00795SulfasalazineProstaglandin G/H synthase 2target
DB00795SulfasalazinePeroxisome proliferator-activated receptor gammatarget
DB00795SulfasalazineProstaglandin G/H synthase 1target
DB00795SulfasalazineArachidonate 5-lipoxygenasetarget
DB00795SulfasalazineProton-coupled folate transportertransporter
DB00795SulfasalazineThromboxane-A synthasetarget
DB00795SulfasalazinePhospholipase A2target
DB00795SulfasalazineSolute carrier organic anion transporter family member 1B1transporter
DB00795SulfasalazineSolute carrier organic anion transporter family member 1B3transporter
DB00795SulfasalazineSolute carrier organic anion transporter family member 2B1transporter
DB00233Aminosalicylic Acid2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinasetarget
DB00233Aminosalicylic AcidGroup IIE secretory phospholipase A2target
DB00233Aminosalicylic AcidProstaglandin G/H synthase 2target
DB00233Aminosalicylic AcidArachidonate 5-lipoxygenasetarget
DB00233Aminosalicylic AcidInhibitor of nuclear factor kappa-B kinase subunit alphatarget
DB00233Aminosalicylic AcidMyeloperoxidaseenzyme
DB00861DiflunisalProstaglandin G/H synthase 1target
DB00861DiflunisalProstaglandin G/H synthase 2target
DB00861DiflunisalTransthyretincarrier
DB00861DiflunisalSerum albumincarrier
DB00861DiflunisalSolute carrier family 22 member 6transporter
DB00861DiflunisalUDP-glucuronosyltransferase 1-8enzyme
DB00861DiflunisalUDP-glucuronosyltransferase 1-9enzyme
DB12445NitroaspirinProstaglandin G/H synthase 1target
DB11079Trolamine salicylateProstaglandin G/H synthase 1target
DB11079Trolamine salicylateProstaglandin G/H synthase 2target
DB01294Bismuth subsalicylateSerum albumincarrier
DB01294Bismuth subsalicylateSerotransferrincarrier
DB14006Choline salicylateCholine-phosphate cytidylyltransferase Btarget
DB14006Choline salicylateAcetylcholinesterasetarget
DB14006Choline salicylateCholine-phosphate cytidylyltransferase Atarget
DB14006Choline salicylatePhospholipase D2target
DB14006Choline salicylateCholinesterasetarget
DB14006Choline salicylatePhospholipase D1target
DB14006Choline salicylatePhosphoethanolamine/phosphocholine phosphatasetarget
DB14006Choline salicylateSolute carrier family 22 member 2transporter
DB14006Choline salicylateSolute carrier family 22 member 1transporter
DB14006Choline salicylateSolute carrier family 22 member 3transporter
DB14006Choline salicylateSolute carrier family 22 member 5transporter
DB14006Choline salicylateSolute carrier family 22 member 4transporter
DB14006Choline salicylateCholine/ethanolaminephosphotransferase 1enzyme
DB14006Choline salicylateCholine transporter-like protein 1transporter
DB14006Choline salicylateCholine transporter-like protein 4transporter
DB14006Choline salicylateCholine transporter-like protein 2transporter
DB14006Choline salicylateCholine transporter-like protein 3transporter
DB14006Choline salicylateCholine/ethanolamine kinaseenzyme
DB14006Choline salicylateCholine O-acetyltransferaseenzyme
DB14006Choline salicylateCholine kinase alphaenzyme
DB14006Choline salicylateCholine dehydrogenase, mitochondrialenzyme
DB14006Choline salicylateHigh affinity choline transporter 1transporter
DB14006Choline salicylateNeuronal acetylcholine receptor subunit alpha-7target