Identification

Name
Mesalazine
Accession Number
DB00244  (APRD01098, DB05376, DB06396)
Type
Small Molecule
Groups
Approved
Description

An anti-inflammatory agent, structurally related to the salicylates, which is active in inflammatory bowel disease. It is considered to be the active moiety of sulphasalazine. (From Martindale, The Extra Pharmacopoeia, 30th ed)

Structure
Thumb
Synonyms
  • 3-carboxy-4-hydroxyaniline
  • 5-aminosalicylic acid
  • 5-ASA
  • m-Aminosalicylic acid
  • Mesalamine
  • Mesalazina
  • Mésalazine
  • Mesalazinum
  • p-Aminosalicylsaeure
External IDs
MAX-002 / SPD476
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
5-asaTablet, delayed release400 mgOralSanis Health Inc2010-11-022012-08-03Canada
AprisoCapsule, extended release375 mg/1OralAphena Pharma Solutions Tennessee, Inc.2008-10-31Not applicableUs
AprisoCapsule, extended release375 mg/1OralPhysicians Total Care, Inc.2010-08-18Not applicableUs
AprisoCapsule, extended release375 mg/1OralSalix Pharmaceuticals2008-10-31Not applicableUs65649 0103 02 nlmimage10 eb39758b
AsacolTablet, delayed release400 mgOralAllergan1993-12-31Not applicableCanada
AsacolTablet400 mg/1OralRemedy Repack2011-08-172016-11-08Us00149 0752 15 nlmimage10 cf12e7c7
AsacolTablet, delayed release400 mg/1OralCardinal Health1992-04-012018-05-11Us
AsacolTablet, delayed release400 mg/1OralKaiser Foundations Hospitals2012-02-23Not applicableUs
AsacolTablet, delayed release400 mg/1OralRemedy Repack2011-03-092017-11-28Us
AsacolTablet, delayed release400 mg/1OralLake Erie Medical &Surgical Supply Dba Quality Care Products Llc2012-03-232016-12-24Us
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
MesalamineEnema4 g/60mLRectalGavis Pharmaceuticals, LLC.2009-12-16Not applicableUs
MesalamineTablet, delayed release1.2 g/1OralZydus Pharmaceuticals Usa, Inc.2017-06-19Not applicableUs
MesalamineTablet, delayed release800 mg/1OralZydus Pharmaceuticals Usa, Inc.2016-08-01Not applicableUs
MesalamineTablet, delayed release800 mg/1OralZydus Pharmaceuticals Usa, Inc.2016-08-01Not applicableUs
MesalamineKitPerrigo New York Inc.2009-09-01Not applicableUs
MesalamineTablet, delayed release1.2 g/1OralCadila Pharnmaceuticals2017-06-19Not applicableUs
MesalamineEnema4 g/60mLRectalANI Pharmaceuticals, Inc.2016-05-13Not applicableUs
MesalamineTablet, delayed release1.2 g/1OralActavis Pharma Company2018-03-26Not applicableUs
MesalamineTablet, delayed release1.2 g/1OralShire2007-01-16Not applicableUs
MesalamineEnema4 g/60mLRectalPerrigo New York Inc.2007-10-11Not applicableUs
International/Other Brands
Asacol / Asacolitin / Canasa / Claversal / Fisalamine / Iialda / Lixacol / Mesasal / Pentasa / Rowasa / Salofalk
Categories
UNII
4Q81I59GXC
CAS number
89-57-6
Weight
Average: 153.1354
Monoisotopic: 153.042593095
Chemical Formula
C7H7NO3
InChI Key
KBOPZPXVLCULAV-UHFFFAOYSA-N
InChI
InChI=1S/C7H7NO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,8H2,(H,10,11)
IUPAC Name
5-amino-2-hydroxybenzoic acid
SMILES
NC1=CC(C(O)=O)=C(O)C=C1

Pharmacology

Indication

For the treatment of active ulcerative proctitis.

Associated Conditions
Pharmacodynamics

Mesalazine (INN, BAN), also known as Mesalamine (USAN) or 5-aminosalicylic acid (5-ASA), is an anti-inflammatory drug used to treat inflammation of the digestive tract (Crohn's disease) and mild to moderate ulcerative colitis. Mesalazine is a bowel-specific aminosalicylate drug that is metabolized in the gut and has its predominant actions there, thereby having fewer systemic side effects. As a derivative of salicylic acid, 5-ASA is also an antioxidant that traps free radicals, which are potentially damaging by-products of metabolism.

Mechanism of action

Although the mechanism of action of mesalazine is not fully understood, it appears to be topical rather than systemic. Mucosal production of arachidonic acid metabolites, both through the cyclooxygenase pathways, i.e., prostanoids, and through the lipoxygenase pathways, i.e., leukotrienes and hydroxyeicosatetraenoic acids, is increased in patients with chronic inflammatory bowel disease, and it is possible that mesalazine diminishes inflammation by blocking cyclooxygenase and inhibiting prostaglandin production in the colon.

TargetActionsOrganism
AProstaglandin G/H synthase 2
inhibitor
Human
AProstaglandin G/H synthase 1
inhibitor
Human
AArachidonate 5-lipoxygenase
inhibitor
Human
APeroxisome proliferator-activated receptor gamma
agonist
Human
UInhibitor of nuclear factor kappa-B kinase subunit alpha
inhibitor
Human
UInhibitor of nuclear factor kappa-B kinase subunit beta
inhibitor
Human
UMyeloperoxidaseNot AvailableHuman
UArylamine N-acetyltransferaseNot AvailableMycobacterium tuberculosis
Absorption

20 to 30% absorbed following oral administration. 10 to 35% absorbed from the colon (rectal suppository) - extent of absorption is determined by the length of time the drug is retained in the colon.

Volume of distribution
Not Available
Protein binding

About 80% of N-Ac-5-ASA is bound to plasma proteins, whereas 40% of mesalamine is protein bound.

Metabolism

Rapidly and extensively metabolized, mainly to N-acetyl-5-ASA (Ac-5-ASA) in the intestinal mucosal wall and the liver. Ac-5-ASA is further acetylated (deactivated) in at least 2 sites, the colonic epithelium and the liver.

Route of elimination

Approximately 28% of the mesalamine in Asacol tablets is absorbed after oral ingestion, leaving the remainder available for topical action and excretion in the feces. It is excreted mainly by the kidney as N-acetyl-5-aminosalicylic acid.

Half life

The mean elimination half-life was 5 hours for 5-ASA and six hours for N-acetyl-5-ASA following the initial dose. At steady state, the mean elimination half-life was seven hours for both 5-ASA and N-acetyl-5-ASA.

Clearance
Not Available
Toxicity

Oral, mouse: LD50 = 3370 mg/kg; Oral, rat: LD50 = 2800 mg/kg; Skin, rabbit: LD50 = >5 gm/kg. There have been no documented reports of serious toxicity in man resulting from massive overdosing with mesalamine. Under ordinary circumstances, mesalazine absorption from the colon is limited.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
(4R)-limoneneThe risk or severity of adverse effects can be increased when (4R)-limonene is combined with Mesalazine.Investigational
16-BromoepiandrosteroneThe risk or severity of adverse effects can be increased when Mesalazine is combined with 16-Bromoepiandrosterone.Investigational
19-norandrostenedioneThe risk or severity of adverse effects can be increased when Mesalazine is combined with 19-norandrostenedione.Experimental, Illicit
5-androstenedioneThe risk or severity of adverse effects can be increased when Mesalazine is combined with 5-androstenedione.Experimental, Illicit
AbciximabThe risk or severity of adverse effects can be increased when Abciximab is combined with Mesalazine.Approved
AcarboseMesalazine may increase the hypoglycemic activities of Acarbose.Approved, Investigational
AcebutololMesalazine may decrease the antihypertensive activities of Acebutolol.Approved, Investigational
AceclofenacThe risk or severity of adverse effects can be increased when Mesalazine is combined with Aceclofenac.Approved, Investigational
AcemetacinThe risk or severity of adverse effects can be increased when Mesalazine is combined with Acemetacin.Approved, Experimental, Investigational
AcenocoumarolMesalazine may increase the anticoagulant activities of Acenocoumarol.Approved, Investigational
AcetaminophenThe risk or severity of adverse effects can be increased when Mesalazine is combined with Acetaminophen.Approved
AcetazolamideThe risk or severity of adverse effects can be increased when Mesalazine is combined with Acetazolamide.Approved, Vet Approved
AcetyldigitoxinThe serum concentration of Acetyldigitoxin can be decreased when it is combined with Mesalazine.Approved
AcetyldigoxinThe serum concentration of Acetyldigoxin can be decreased when it is combined with Mesalazine.Experimental
AdapaleneThe risk or severity of adverse effects can be increased when Adapalene is combined with Mesalazine.Approved
AlaproclateAlaproclate may increase the antiplatelet activities of Mesalazine.Experimental
AlbiglutideMesalazine may increase the hypoglycemic activities of Albiglutide.Approved
AlclofenacThe risk or severity of adverse effects can be increased when Alclofenac is combined with Mesalazine.Approved, Withdrawn
AlclometasoneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Alclometasone.Approved
AldosteroneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Aldosterone.Experimental, Investigational
Alendronic acidThe risk or severity of adverse effects can be increased when Mesalazine is combined with Alendronic acid.Approved
AliskirenMesalazine may decrease the antihypertensive activities of Aliskiren.Approved, Investigational
AlmasilateThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Almasilate.Approved, Experimental
AlminoprofenThe risk or severity of adverse effects can be increased when Alminoprofen is combined with Mesalazine.Experimental
AlogliptinMesalazine may increase the hypoglycemic activities of Alogliptin.Approved
AloglutamolThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Aloglutamol.Approved
AloxiprinThe risk or severity of adverse effects can be increased when Mesalazine is combined with Aloxiprin.Experimental
AlprenololMesalazine may decrease the antihypertensive activities of Alprenolol.Approved, Withdrawn
AlprostadilThe risk or severity of adverse effects can be increased when Alprostadil is combined with Mesalazine.Approved, Investigational
AlteplaseThe risk or severity of adverse effects can be increased when Mesalazine is combined with Alteplase.Approved
AluminiumThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Aluminium.Approved, Investigational
Aluminium acetoacetateThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Aluminium acetoacetate.Experimental
Aluminium glycinateThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Aluminium glycinate.Experimental
Aluminum hydroxideThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Aluminum hydroxide.Approved, Investigational
AmcinonideThe risk or severity of adverse effects can be increased when Mesalazine is combined with Amcinonide.Approved
AmikacinMesalazine may decrease the excretion rate of Amikacin which could result in a higher serum level.Approved, Investigational, Vet Approved
AmilorideMesalazine may decrease the antihypertensive activities of Amiloride.Approved
Aminosalicylic AcidThe risk or severity of adverse effects can be increased when Mesalazine is combined with Aminosalicylic Acid.Approved
AmiodaroneMesalazine may decrease the antihypertensive activities of Amiodarone.Approved, Investigational
Ammonium chlorideThe serum concentration of Mesalazine can be increased when it is combined with Ammonium chloride.Approved, Investigational, Vet Approved
AnagrelideThe risk or severity of adverse effects can be increased when Anagrelide is combined with Mesalazine.Approved
AncrodMesalazine may increase the anticoagulant activities of Ancrod.Approved, Investigational
AndrographolideThe risk or severity of adverse effects can be increased when Andrographolide is combined with Mesalazine.Investigational
AndrostenedioneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Androstenedione.Experimental, Illicit
AnecortaveThe risk or severity of adverse effects can be increased when Mesalazine is combined with Anecortave.Investigational
anecortave acetateThe risk or severity of adverse effects can be increased when Mesalazine is combined with anecortave acetate.Investigational
AnisodamineThe risk or severity of adverse effects can be increased when Anisodamine is combined with Mesalazine.Investigational
AnistreplaseThe risk or severity of adverse effects can be increased when Mesalazine is combined with Anistreplase.Approved
AntipyrineThe risk or severity of adverse effects can be increased when Mesalazine is combined with Antipyrine.Approved, Investigational
Antithrombin III humanMesalazine may increase the anticoagulant activities of Antithrombin III human.Approved
AntrafenineThe risk or severity of adverse effects can be increased when Mesalazine is combined with Antrafenine.Approved
ApixabanMesalazine may increase the anticoagulant activities of Apixaban.Approved
ApocyninThe risk or severity of adverse effects can be increased when Apocynin is combined with Mesalazine.Investigational
ApramycinMesalazine may decrease the excretion rate of Apramycin which could result in a higher serum level.Experimental, Vet Approved
ApremilastThe risk or severity of adverse effects can be increased when Apremilast is combined with Mesalazine.Approved, Investigational
ArbekacinMesalazine may decrease the excretion rate of Arbekacin which could result in a higher serum level.Approved, Investigational
ArdeparinMesalazine may increase the anticoagulant activities of Ardeparin.Approved, Investigational, Withdrawn
ArgatrobanThe risk or severity of adverse effects can be increased when Argatroban is combined with Mesalazine.Approved, Investigational
ArotinololMesalazine may decrease the antihypertensive activities of Arotinolol.Investigational
AsenapineThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Asenapine.Approved
AstaxanthinThe risk or severity of adverse effects can be increased when Mesalazine is combined with Astaxanthin.Investigational
AtamestaneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Atamestane.Investigational
AtenololMesalazine may decrease the antihypertensive activities of Atenolol.Approved
AzapropazoneThe risk or severity of adverse effects can be increased when Azapropazone is combined with Mesalazine.Withdrawn
AzathioprineThe metabolism of Azathioprine can be decreased when combined with Mesalazine.Approved
AzelastineThe risk or severity of adverse effects can be increased when Azelastine is combined with Mesalazine.Approved
Azficel-TThe risk or severity of adverse effects can be increased when Mesalazine is combined with Azficel-T.Approved, Investigational
Azilsartan medoxomilThe risk or severity of adverse effects can be increased when Azilsartan medoxomil is combined with Mesalazine.Approved, Investigational
AzosemideThe therapeutic efficacy of Azosemide can be decreased when used in combination with Mesalazine.Investigational
BalsalazideThe risk or severity of adverse effects can be increased when Mesalazine is combined with Balsalazide.Approved, Investigational
BatroxobinThe risk or severity of adverse effects can be increased when Mesalazine is combined with Batroxobin.Experimental
BazedoxifeneMesalazine may increase the thrombogenic activities of Bazedoxifene.Approved, Investigational
BecaplerminMesalazine may increase the anticoagulant activities of Becaplermin.Approved, Investigational
Beclomethasone dipropionateThe risk or severity of adverse effects can be increased when Mesalazine is combined with Beclomethasone dipropionate.Approved, Investigational
BefunololMesalazine may decrease the antihypertensive activities of Befunolol.Experimental
BekanamycinMesalazine may decrease the excretion rate of Bekanamycin which could result in a higher serum level.Experimental
BemiparinThe risk or severity of adverse effects can be increased when Mesalazine is combined with Bemiparin.Approved, Investigational
BenazeprilThe therapeutic efficacy of Benazepril can be decreased when used in combination with Mesalazine.Approved, Investigational
BendazacThe risk or severity of adverse effects can be increased when Bendazac is combined with Mesalazine.Experimental
BendroflumethiazideThe therapeutic efficacy of Bendroflumethiazide can be decreased when used in combination with Mesalazine.Approved
BenorilateThe risk or severity of adverse effects can be increased when Benorilate is combined with Mesalazine.Experimental
BenoxaprofenThe risk or severity of adverse effects can be increased when Benoxaprofen is combined with Mesalazine.Withdrawn
BenzthiazideThe therapeutic efficacy of Benzthiazide can be decreased when used in combination with Mesalazine.Approved
BenzydamineThe risk or severity of adverse effects can be increased when Benzydamine is combined with Mesalazine.Approved
BeraprostThe risk or severity of adverse effects can be increased when Beraprost is combined with Mesalazine.Investigational
BetamethasoneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Betamethasone.Approved, Vet Approved
BetaxololMesalazine may decrease the antihypertensive activities of Betaxolol.Approved, Investigational
BetrixabanThe risk or severity of bleeding can be increased when Betrixaban is combined with Mesalazine.Approved, Investigational
BevantololMesalazine may decrease the antihypertensive activities of Bevantolol.Approved
BevoniumThe risk or severity of adverse effects can be increased when Bevonium is combined with Mesalazine.Experimental
BimatoprostThe therapeutic efficacy of Bimatoprost can be decreased when used in combination with Mesalazine.Approved, Investigational
Bismuth SubcitrateThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Bismuth Subcitrate.Approved, Investigational
Bismuth subnitrateThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Bismuth subnitrate.Approved
BisoprololMesalazine may decrease the antihypertensive activities of Bisoprolol.Approved
BivalirudinMesalazine may increase the anticoagulant activities of Bivalirudin.Approved, Investigational
BopindololMesalazine may decrease the antihypertensive activities of Bopindolol.Approved
BrinaseThe risk or severity of adverse effects can be increased when Mesalazine is combined with Brinase.Experimental
BrinzolamideThe risk or severity of adverse effects can be increased when Mesalazine is combined with Brinzolamide.Approved
BromfenacThe risk or severity of adverse effects can be increased when Bromfenac is combined with Mesalazine.Approved
BromocriptineMesalazine may increase the hypoglycemic activities of Bromocriptine.Approved, Investigational
BucillamineThe risk or severity of adverse effects can be increased when Bucillamine is combined with Mesalazine.Investigational
BucindololMesalazine may decrease the antihypertensive activities of Bucindolol.Investigational
BudesonideThe risk or severity of adverse effects can be increased when Mesalazine is combined with Budesonide.Approved
BufexamacThe risk or severity of adverse effects can be increased when Mesalazine is combined with Bufexamac.Approved, Experimental
BuflomedilThe risk or severity of adverse effects can be increased when Buflomedil is combined with Mesalazine.Experimental
BufuralolMesalazine may decrease the antihypertensive activities of Bufuralol.Experimental, Investigational
BumadizoneThe risk or severity of adverse effects can be increased when Bumadizone is combined with Mesalazine.Experimental
BumetanideThe therapeutic efficacy of Bumetanide can be decreased when used in combination with Mesalazine.Approved
BupranololMesalazine may decrease the antihypertensive activities of Bupranolol.Approved
ButylphthalideThe risk or severity of adverse effects can be increased when Butylphthalide is combined with Mesalazine.Investigational
Calcium CarbonateThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Calcium Carbonate.Approved, Investigational
Calcium silicateThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Calcium silicate.Experimental
CanagliflozinMesalazine may increase the hypoglycemic activities of Canagliflozin.Approved
CandesartanThe risk or severity of adverse effects can be increased when Candesartan is combined with Mesalazine.Experimental
Candesartan cilexetilThe risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Mesalazine.Approved
CandoxatrilThe therapeutic efficacy of Candoxatril can be decreased when used in combination with Mesalazine.Experimental
CangrelorThe risk or severity of adverse effects can be increased when Cangrelor is combined with Mesalazine.Approved
CaplacizumabThe risk or severity of adverse effects can be increased when Mesalazine is combined with Caplacizumab.Investigational
CapsaicinThe risk or severity of adverse effects can be increased when Mesalazine is combined with Capsaicin.Approved
CaptoprilThe therapeutic efficacy of Captopril can be decreased when used in combination with Mesalazine.Approved
Carbaspirin calciumThe risk or severity of adverse effects can be increased when Carbaspirin calcium is combined with Mesalazine.Experimental, Investigational
Carboprost TromethamineThe therapeutic efficacy of Carboprost Tromethamine can be decreased when used in combination with Mesalazine.Approved
CarprofenThe risk or severity of adverse effects can be increased when Mesalazine is combined with Carprofen.Approved, Vet Approved, Withdrawn
CarteololMesalazine may decrease the antihypertensive activities of Carteolol.Approved
CarvedilolMesalazine may decrease the antihypertensive activities of Carvedilol.Approved, Investigational
CastanospermineThe risk or severity of adverse effects can be increased when Castanospermine is combined with Mesalazine.Experimental
CelecoxibThe risk or severity of adverse effects can be increased when Mesalazine is combined with Celecoxib.Approved, Investigational
CeliprololMesalazine may decrease the antihypertensive activities of Celiprolol.Approved, Investigational
CertoparinMesalazine may increase the anticoagulant activities of Certoparin.Approved, Investigational
ChloroquineThe risk or severity of adverse effects can be increased when Chloroquine is combined with Mesalazine.Approved, Investigational, Vet Approved
ChlorothiazideThe therapeutic efficacy of Chlorothiazide can be decreased when used in combination with Mesalazine.Approved, Vet Approved
ChlorotrianiseneMesalazine may increase the thrombogenic activities of Chlorotrianisene.Investigational, Withdrawn
ChlorphenesinThe risk or severity of adverse effects can be increased when Mesalazine is combined with Chlorphenesin.Approved, Vet Approved, Withdrawn
ChlorpropamideMesalazine may increase the hypoglycemic activities of Chlorpropamide.Approved, Investigational
ChlorthalidoneThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Mesalazine.Approved
CholestyramineCholestyramine can cause a decrease in the absorption of Mesalazine resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
Choline magnesium trisalicylateThe risk or severity of adverse effects can be increased when Mesalazine is combined with Choline magnesium trisalicylate.Approved
CiclesonideThe risk or severity of adverse effects can be increased when Mesalazine is combined with Ciclesonide.Approved, Investigational
CilazaprilThe therapeutic efficacy of Cilazapril can be decreased when used in combination with Mesalazine.Approved
CilostazolThe risk or severity of adverse effects can be increased when Cilostazol is combined with Mesalazine.Approved, Investigational
CimetidineThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Cimetidine.Approved, Investigational
CimicoxibThe risk or severity of adverse effects can be increased when Mesalazine is combined with Cimicoxib.Investigational
CinoxacinMesalazine may increase the neuroexcitatory activities of Cinoxacin.Approved, Investigational, Withdrawn
CiprofloxacinMesalazine may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
CisplatinThe risk or severity of adverse effects can be increased when Mesalazine is combined with Cisplatin.Approved
CitalopramCitalopram may increase the antiplatelet activities of Mesalazine.Approved
Citric AcidMesalazine may increase the anticoagulant activities of Citric Acid.Approved, Nutraceutical, Vet Approved
ClobetasolThe risk or severity of adverse effects can be increased when Mesalazine is combined with Clobetasol.Approved, Investigational
Clobetasol propionateThe risk or severity of adverse effects can be increased when Mesalazine is combined with Clobetasol propionate.Approved
ClobetasoneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Clobetasone.Approved
ClocortoloneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Clocortolone.Approved
Clodronic AcidThe risk or severity of adverse effects can be increased when Mesalazine is combined with Clodronic Acid.Approved, Investigational, Vet Approved
ClonixinThe risk or severity of adverse effects can be increased when Clonixin is combined with Mesalazine.Approved
ClopidogrelThe risk or severity of adverse effects can be increased when Clopidogrel is combined with Mesalazine.Approved
CloprostenolThe therapeutic efficacy of Cloprostenol can be decreased when used in combination with Mesalazine.Vet Approved
CloranololMesalazine may decrease the antihypertensive activities of Cloranolol.Experimental
CloricromenThe risk or severity of adverse effects can be increased when Cloricromen is combined with Mesalazine.Experimental
ClorindioneMesalazine may increase the anticoagulant activities of Clorindione.Experimental
ColesevelamColesevelam can cause a decrease in the absorption of Mesalazine resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
ColestipolColestipol can cause a decrease in the absorption of Mesalazine resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Conjugated estrogensMesalazine may increase the thrombogenic activities of Conjugated estrogens.Approved
Cortexolone 17α-propionateThe risk or severity of adverse effects can be increased when Mesalazine is combined with Cortexolone 17α-propionate.Investigational
CorticosteroneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Corticosterone.Experimental
Cortisone acetateThe risk or severity of adverse effects can be increased when Mesalazine is combined with Cortisone acetate.Approved, Investigational
CurcuminThe risk or severity of adverse effects can be increased when Curcumin is combined with Mesalazine.Approved, Investigational
CyclopenthiazideThe therapeutic efficacy of Cyclopenthiazide can be decreased when used in combination with Mesalazine.Experimental
CyclosporineMesalazine may increase the nephrotoxic activities of Cyclosporine.Approved, Investigational, Vet Approved
CymarinThe serum concentration of Cymarin can be decreased when it is combined with Mesalazine.Experimental
Dabigatran etexilateMesalazine may increase the anticoagulant activities of Dabigatran etexilate.Approved
DaidzeinMesalazine may increase the thrombogenic activities of Daidzein.Experimental
DalteparinMesalazine may increase the anticoagulant activities of Dalteparin.Approved
DanaparoidMesalazine may increase the anticoagulant activities of Danaparoid.Approved, Withdrawn
DapagliflozinMesalazine may increase the hypoglycemic activities of Dapagliflozin.Approved
DapoxetineDapoxetine may increase the antiplatelet activities of Mesalazine.Investigational
DarexabanMesalazine may increase the anticoagulant activities of Darexaban.Investigational
DeferasiroxThe risk or severity of adverse effects can be increased when Mesalazine is combined with Deferasirox.Approved, Investigational
DefibrotideThe risk or severity of adverse effects can be increased when Defibrotide is combined with Mesalazine.Approved, Investigational
DeflazacortThe risk or severity of adverse effects can be increased when Mesalazine is combined with Deflazacort.Approved, Investigational
DelaprilThe therapeutic efficacy of Delapril can be decreased when used in combination with Mesalazine.Experimental
DersalazineMesalazine may increase the anticoagulant activities of Dersalazine.Investigational
DesipramineMesalazine may decrease the antihypertensive activities of Desipramine.Approved, Investigational
DesirudinMesalazine may increase the anticoagulant activities of Desirudin.Approved
DeslanosideThe serum concentration of Deslanoside can be decreased when it is combined with Mesalazine.Approved
DesmopressinThe risk or severity of adverse effects can be increased when Mesalazine is combined with Desmopressin.Approved
DesmoteplaseThe risk or severity of adverse effects can be increased when Mesalazine is combined with Desmoteplase.Investigational
DesonideThe risk or severity of adverse effects can be increased when Mesalazine is combined with Desonide.Approved, Investigational
DesoximetasoneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Desoximetasone.Approved
Desoxycorticosterone acetateThe risk or severity of adverse effects can be increased when Mesalazine is combined with Desoxycorticosterone acetate.Approved
Desoxycorticosterone PivalateThe risk or severity of adverse effects can be increased when Mesalazine is combined with Desoxycorticosterone Pivalate.Experimental, Vet Approved
DesvenlafaxineDesvenlafaxine may increase the antiplatelet activities of Mesalazine.Approved, Investigational
DexamethasoneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Dexamethasone.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe risk or severity of adverse effects can be increased when Mesalazine is combined with Dexamethasone isonicotinate.Vet Approved
DexibuprofenThe risk or severity of adverse effects can be increased when Mesalazine is combined with Dexibuprofen.Approved, Investigational
DexketoprofenThe risk or severity of adverse effects can be increased when Mesalazine is combined with Dexketoprofen.Approved, Investigational
DexlansoprazoleThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Dexlansoprazole.Approved, Investigational
DexrabeprazoleThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Dexrabeprazole.Experimental
DextranMesalazine may increase the anticoagulant activities of Dextran.Approved, Investigational, Vet Approved
DibekacinMesalazine may decrease the excretion rate of Dibekacin which could result in a higher serum level.Experimental
Dibotermin alfaThe risk or severity of adverse effects can be increased when Mesalazine is combined with Dibotermin alfa.Approved, Investigational
DiclofenacThe risk or severity of adverse effects can be increased when Diclofenac is combined with Mesalazine.Approved, Vet Approved
DiclofenamideThe risk or severity of adverse effects can be increased when Mesalazine is combined with Diclofenamide.Approved, Investigational
DicoumarolMesalazine may increase the anticoagulant activities of Dicoumarol.Approved
DienestrolMesalazine may increase the thrombogenic activities of Dienestrol.Approved, Investigational
DiethylstilbestrolMesalazine may increase the thrombogenic activities of Diethylstilbestrol.Approved, Investigational
DifenpiramideThe risk or severity of adverse effects can be increased when Difenpiramide is combined with Mesalazine.Experimental
DiflorasoneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Diflorasone.Approved
DiflunisalThe risk or severity of adverse effects can be increased when Mesalazine is combined with Diflunisal.Approved, Investigational
DifluocortoloneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Difluocortolone.Approved, Investigational, Withdrawn
DifluprednateThe risk or severity of adverse effects can be increased when Mesalazine is combined with Difluprednate.Approved
DigitoxinThe serum concentration of Digitoxin can be decreased when it is combined with Mesalazine.Approved, Investigational
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Mesalazine.Approved
Digoxin Immune Fab (Ovine)The serum concentration of Digoxin Immune Fab (Ovine) can be decreased when it is combined with Mesalazine.Approved
DihydrostreptomycinMesalazine may decrease the excretion rate of Dihydrostreptomycin which could result in a higher serum level.Investigational, Vet Approved
DiltiazemDiltiazem may increase the anticoagulant activities of Mesalazine.Approved, Investigational
DinoprostThe therapeutic efficacy of Dinoprost can be decreased when used in combination with Mesalazine.Investigational
Dinoprost TromethamineThe therapeutic efficacy of Dinoprost Tromethamine can be decreased when used in combination with Mesalazine.Approved, Vet Approved
DinoprostoneThe therapeutic efficacy of Dinoprostone can be decreased when used in combination with Mesalazine.Approved
DiphenadioneMesalazine may increase the anticoagulant activities of Diphenadione.Experimental
DipyridamoleThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Mesalazine.Approved
DisopyramideMesalazine may increase the hypoglycemic activities of Disopyramide.Approved
DitazoleThe risk or severity of adverse effects can be increased when Mesalazine is combined with Ditazole.Approved, Withdrawn
DorzolamideThe risk or severity of adverse effects can be increased when Mesalazine is combined with Dorzolamide.Approved
DoxepinThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Doxepin.Approved, Investigational
DrospirenoneMesalazine may increase the hyperkalemic activities of Drospirenone.Approved
Drotrecogin alfaThe risk or severity of adverse effects can be increased when Mesalazine is combined with Drotrecogin alfa.Approved, Investigational, Withdrawn
DroxicamThe risk or severity of adverse effects can be increased when Mesalazine is combined with Droxicam.Withdrawn
DulaglutideMesalazine may increase the hypoglycemic activities of Dulaglutide.Approved, Investigational
DuloxetineDuloxetine may increase the antiplatelet activities of Mesalazine.Approved
DuvelisibThe risk or severity of adverse effects can be increased when Duvelisib is combined with Mesalazine.Investigational
E-6201The risk or severity of adverse effects can be increased when E-6201 is combined with Mesalazine.Investigational
Edetic AcidMesalazine may increase the anticoagulant activities of Edetic Acid.Approved, Vet Approved
EdoxabanMesalazine may increase the anticoagulant activities of Edoxaban.Approved
EmpagliflozinMesalazine may increase the hypoglycemic activities of Empagliflozin.Approved
EnalaprilThe therapeutic efficacy of Enalapril can be decreased when used in combination with Mesalazine.Approved, Vet Approved
EnalaprilatThe therapeutic efficacy of Enalaprilat can be decreased when used in combination with Mesalazine.Approved
EnoxacinMesalazine may increase the neuroexcitatory activities of Enoxacin.Approved, Investigational
EnoxaparinMesalazine may increase the anticoagulant activities of Enoxaparin.Approved
EnprostilThe therapeutic efficacy of Enprostil can be decreased when used in combination with Mesalazine.Experimental
EpanololMesalazine may decrease the antihypertensive activities of Epanolol.Experimental
EpimestrolMesalazine may increase the thrombogenic activities of Epimestrol.Experimental
EpinastineThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Epinastine.Approved, Investigational
EpirizoleThe risk or severity of adverse effects can be increased when Epirizole is combined with Mesalazine.Approved
EpitizideThe therapeutic efficacy of Epitizide can be decreased when used in combination with Mesalazine.Experimental
EplerenoneMesalazine may decrease the antihypertensive activities of Eplerenone.Approved
EplivanserinThe risk or severity of adverse effects can be increased when Eplivanserin is combined with Mesalazine.Investigational
eplivanserineThe risk or severity of adverse effects can be increased when eplivanserine is combined with Mesalazine.Investigational
EpoprostenolThe risk or severity of adverse effects can be increased when Epoprostenol is combined with Mesalazine.Approved
EprosartanThe risk or severity of adverse effects can be increased when Eprosartan is combined with Mesalazine.Approved
EptifibatideThe risk or severity of adverse effects can be increased when Eptifibatide is combined with Mesalazine.Approved, Investigational
EquileninThe risk or severity of adverse effects can be increased when Mesalazine is combined with Equilenin.Experimental
EquilinThe risk or severity of adverse effects can be increased when Mesalazine is combined with Equilin.Approved
EquolMesalazine may increase the thrombogenic activities of Equol.Investigational
EsatenololMesalazine may decrease the antihypertensive activities of Esatenolol.Experimental
EscitalopramEscitalopram may increase the antiplatelet activities of Mesalazine.Approved, Investigational
EsmololMesalazine may decrease the antihypertensive activities of Esmolol.Approved
EsomeprazoleThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Esomeprazole.Approved, Investigational
EstradiolMesalazine may increase the thrombogenic activities of Estradiol.Approved, Investigational, Vet Approved
Estradiol acetateMesalazine may increase the thrombogenic activities of Estradiol acetate.Approved, Investigational, Vet Approved
Estradiol cypionateMesalazine may increase the thrombogenic activities of Estradiol cypionate.Approved, Investigational, Vet Approved
Estradiol valerateMesalazine may increase the thrombogenic activities of Estradiol valerate.Approved, Investigational, Vet Approved
EstriolMesalazine may increase the thrombogenic activities of Estriol.Approved, Investigational, Vet Approved
Estrogens, esterifiedMesalazine may increase the thrombogenic activities of Estrogens, esterified.Approved
EstroneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Estrone.Approved
Estrone sulfateThe risk or severity of adverse effects can be increased when Mesalazine is combined with Estrone sulfate.Approved
Etacrynic acidThe therapeutic efficacy of Etacrynic acid can be decreased when used in combination with Mesalazine.Approved, Investigational
EtanerceptThe risk or severity of adverse effects can be increased when Etanercept is combined with Mesalazine.Approved, Investigational
EthenzamideThe risk or severity of adverse effects can be increased when Ethenzamide is combined with Mesalazine.Experimental
Ethinyl EstradiolMesalazine may increase the thrombogenic activities of Ethinyl Estradiol.Approved
EthoxzolamideThe risk or severity of adverse effects can be increased when Mesalazine is combined with Ethoxzolamide.Withdrawn
Ethyl biscoumacetateMesalazine may increase the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
Etidronic acidThe risk or severity of adverse effects can be increased when Mesalazine is combined with Etidronic acid.Approved
EtodolacThe risk or severity of adverse effects can be increased when Mesalazine is combined with Etodolac.Approved, Investigational, Vet Approved
EtofenamateThe risk or severity of adverse effects can be increased when Etofenamate is combined with Mesalazine.Approved, Investigational
EtoperidoneEtoperidone may increase the antiplatelet activities of Mesalazine.Withdrawn
EtoricoxibThe risk or severity of adverse effects can be increased when Mesalazine is combined with Etoricoxib.Approved, Investigational
Evening primrose oilThe risk or severity of adverse effects can be increased when Evening primrose oil is combined with Mesalazine.Investigational, Nutraceutical
ExenatideMesalazine may increase the hypoglycemic activities of Exenatide.Approved, Investigational
ExisulindThe risk or severity of adverse effects can be increased when Exisulind is combined with Mesalazine.Investigational
FamotidineThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Famotidine.Approved
FelbinacThe risk or severity of adverse effects can be increased when Felbinac is combined with Mesalazine.Experimental
FenbufenThe risk or severity of adverse effects can be increased when Fenbufen is combined with Mesalazine.Approved
FenoprofenThe risk or severity of adverse effects can be increased when Mesalazine is combined with Fenoprofen.Approved
FenprostaleneThe therapeutic efficacy of Fenprostalene can be decreased when used in combination with Mesalazine.Vet Approved
FentiazacThe risk or severity of adverse effects can be increased when Fentiazac is combined with Mesalazine.Experimental
FeprazoneThe risk or severity of adverse effects can be increased when Feprazone is combined with Mesalazine.Experimental
Ferulic acidThe risk or severity of adverse effects can be increased when Ferulic acid is combined with Mesalazine.Experimental
FibrinolysinThe risk or severity of adverse effects can be increased when Mesalazine is combined with Fibrinolysin.Investigational
FimasartanThe risk or severity of adverse effects can be increased when Fimasartan is combined with Mesalazine.Approved, Investigational
Fish oilThe risk or severity of adverse effects can be increased when Mesalazine is combined with Fish oil.Approved, Nutraceutical
FleroxacinMesalazine may increase the neuroexcitatory activities of Fleroxacin.Approved
FloctafenineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Mesalazine.Approved, Withdrawn
FluasteroneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Fluasterone.Investigational
FludrocortisoneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Fludrocortisone.Approved, Investigational
FluindioneMesalazine may increase the anticoagulant activities of Fluindione.Approved, Investigational
FlumequineMesalazine may increase the neuroexcitatory activities of Flumequine.Withdrawn
FlumethasoneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Flumethasone.Approved, Vet Approved
FlunisolideThe risk or severity of adverse effects can be increased when Mesalazine is combined with Flunisolide.Approved, Investigational
FlunixinThe risk or severity of adverse effects can be increased when Flunixin is combined with Mesalazine.Vet Approved
FlunoxaprofenThe risk or severity of adverse effects can be increased when Flunoxaprofen is combined with Mesalazine.Experimental
Fluocinolone AcetonideThe risk or severity of adverse effects can be increased when Mesalazine is combined with Fluocinolone Acetonide.Approved, Investigational, Vet Approved
FluocinonideThe risk or severity of adverse effects can be increased when Mesalazine is combined with Fluocinonide.Approved, Investigational
FluocortoloneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Fluocortolone.Approved, Withdrawn
FluorometholoneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Fluorometholone.Approved, Investigational
FluoxetineFluoxetine may increase the antiplatelet activities of Mesalazine.Approved, Vet Approved
FluprednideneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Fluprednidene.Approved, Withdrawn
FluprednisoloneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Fluprednisolone.Approved
FluprostenolThe therapeutic efficacy of Fluprostenol can be decreased when used in combination with Mesalazine.Vet Approved
FlurandrenolideThe risk or severity of adverse effects can be increased when Mesalazine is combined with Flurandrenolide.Approved
FlurbiprofenThe risk or severity of adverse effects can be increased when Flurbiprofen is combined with Mesalazine.Approved, Investigational
FluticasoneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Fluticasone.Approved, Experimental, Investigational
Fluticasone furoateThe risk or severity of adverse effects can be increased when Mesalazine is combined with Fluticasone furoate.Approved
Fluticasone propionateThe risk or severity of adverse effects can be increased when Mesalazine is combined with Fluticasone propionate.Approved
FluvoxamineFluvoxamine may increase the antiplatelet activities of Mesalazine.Approved, Investigational
Folic AcidThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Mesalazine.Approved, Nutraceutical, Vet Approved
FondaparinuxMesalazine may increase the anticoagulant activities of Fondaparinux.Approved, Investigational
Fondaparinux sodiumMesalazine may increase the anticoagulant activities of Fondaparinux sodium.Approved, Investigational
ForasartanThe risk or severity of adverse effects can be increased when Forasartan is combined with Mesalazine.Experimental
FormestaneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Formestane.Approved, Investigational, Withdrawn
FosinoprilThe therapeutic efficacy of Fosinopril can be decreased when used in combination with Mesalazine.Approved
FramycetinMesalazine may decrease the excretion rate of Framycetin which could result in a higher serum level.Approved
FurosemideThe therapeutic efficacy of Furosemide can be decreased when used in combination with Mesalazine.Approved, Vet Approved
GabexateMesalazine may increase the anticoagulant activities of Gabexate.Investigational
GarenoxacinMesalazine may increase the neuroexcitatory activities of Garenoxacin.Investigational
GatifloxacinMesalazine may increase the neuroexcitatory activities of Gatifloxacin.Approved, Investigational
GemeprostThe therapeutic efficacy of Gemeprost can be decreased when used in combination with Mesalazine.Approved, Withdrawn
GemifloxacinMesalazine may increase the neuroexcitatory activities of Gemifloxacin.Approved, Investigational
GeneticinMesalazine may decrease the excretion rate of Geneticin which could result in a higher serum level.Experimental
GenisteinMesalazine may increase the thrombogenic activities of Genistein.Investigational
GentamicinMesalazine may decrease the excretion rate of Gentamicin which could result in a higher serum level.Approved, Vet Approved
GENTAMICIN C1AMesalazine may decrease the excretion rate of GENTAMICIN C1A which could result in a higher serum level.Experimental
Ginkgo bilobaGinkgo biloba may increase the anticoagulant activities of Mesalazine.Approved, Investigational, Nutraceutical
GinsengThe risk or severity of adverse effects can be increased when Mesalazine is combined with Ginseng.Approved, Investigational, Nutraceutical
GitoformateThe serum concentration of Gitoformate can be decreased when it is combined with Mesalazine.Experimental
GliclazideMesalazine may increase the hypoglycemic activities of Gliclazide.Approved
GlimepirideMesalazine may increase the hypoglycemic activities of Glimepiride.Approved
GlipizideMesalazine may increase the hypoglycemic activities of Glipizide.Approved, Investigational
GlyburideMesalazine may increase the hypoglycemic activities of Glyburide.Approved
GrepafloxacinMesalazine may increase the neuroexcitatory activities of Grepafloxacin.Approved, Investigational, Withdrawn
GuacetisalThe risk or severity of adverse effects can be increased when Guacetisal is combined with Mesalazine.Experimental
HalcinonideThe risk or severity of adverse effects can be increased when Mesalazine is combined with Halcinonide.Approved, Investigational, Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Mesalazine is combined with Haloperidol.Approved
HE3286The risk or severity of adverse effects can be increased when Mesalazine is combined with HE3286.Investigational
Hemoglobin crosfumarilMesalazine may increase the anticoagulant activities of Hemoglobin crosfumaril.Experimental
HeparinThe risk or severity of adverse effects can be increased when Mesalazine is combined with Heparin.Approved, Investigational
HexestrolMesalazine may increase the thrombogenic activities of Hexestrol.Withdrawn
HigenamineThe risk or severity of adverse effects can be increased when Higenamine is combined with Mesalazine.Investigational
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Mesalazine.Approved, Investigational
HydralazineMesalazine may decrease the antihypertensive activities of Hydralazine.Approved
HydrochlorothiazideThe therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Mesalazine.Approved, Vet Approved
HydrocortisoneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Hydrocortisone.Approved, Vet Approved
HydroflumethiazideThe therapeutic efficacy of Hydroflumethiazide can be decreased when used in combination with Mesalazine.Approved, Investigational
HydrotalciteThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Hydrotalcite.Approved, Experimental, Investigational
HydroxytyrosolThe risk or severity of adverse effects can be increased when Hydroxytyrosol is combined with Mesalazine.Investigational
Hygromycin BMesalazine may decrease the excretion rate of Hygromycin B which could result in a higher serum level.Vet Approved
IbandronateThe risk or severity of adverse effects can be increased when Mesalazine is combined with Ibandronate.Approved, Investigational
IbudilastThe risk or severity of adverse effects can be increased when Ibudilast is combined with Mesalazine.Approved, Investigational
IbuprofenThe risk or severity of adverse effects can be increased when Mesalazine is combined with Ibuprofen.Approved
IbuproxamThe risk or severity of adverse effects can be increased when Ibuproxam is combined with Mesalazine.Withdrawn
IcatibantThe risk or severity of adverse effects can be increased when Icatibant is combined with Mesalazine.Approved, Investigational
IcosapentThe risk or severity of adverse effects can be increased when Mesalazine is combined with Icosapent.Approved, Nutraceutical
Icosapent ethylThe risk or severity of adverse effects can be increased when Icosapent ethyl is combined with Mesalazine.Approved, Investigational, Nutraceutical
IdraparinuxMesalazine may increase the anticoagulant activities of Idraparinux.Investigational
IfenprodilThe risk or severity of adverse effects can be increased when Ifenprodil is combined with Mesalazine.Approved, Investigational, Withdrawn
IfetrobanThe risk or severity of adverse effects can be increased when Ifetroban is combined with Mesalazine.Investigational
IloprostThe risk or severity of adverse effects can be increased when Iloprost is combined with Mesalazine.Approved, Investigational
ImidaprilThe therapeutic efficacy of Imidapril can be decreased when used in combination with Mesalazine.Investigational
Imidazole salicylateThe risk or severity of adverse effects can be increased when Imidazole salicylate is combined with Mesalazine.Experimental
IndalpineIndalpine may increase the antiplatelet activities of Mesalazine.Investigational, Withdrawn
IndapamideThe therapeutic efficacy of Indapamide can be decreased when used in combination with Mesalazine.Approved
IndenololMesalazine may decrease the antihypertensive activities of Indenolol.Withdrawn
IndobufenThe risk or severity of adverse effects can be increased when Indobufen is combined with Mesalazine.Investigational
IndomethacinThe risk or severity of adverse effects can be increased when Mesalazine is combined with Indomethacin.Approved, Investigational
IndoprofenThe risk or severity of adverse effects can be increased when Indoprofen is combined with Mesalazine.Withdrawn
Insulin AspartMesalazine may increase the hypoglycemic activities of Insulin Aspart.Approved
Insulin DetemirMesalazine may increase the hypoglycemic activities of Insulin Detemir.Approved
Insulin GlargineMesalazine may increase the hypoglycemic activities of Insulin Glargine.Approved
Insulin GlulisineMesalazine may increase the hypoglycemic activities of Insulin Glulisine.Approved
Insulin HumanMesalazine may increase the hypoglycemic activities of Insulin Human.Approved, Investigational
Insulin LisproMesalazine may increase the hypoglycemic activities of Insulin Lispro.Approved
IrbesartanThe risk or severity of adverse effects can be increased when Irbesartan is combined with Mesalazine.Approved, Investigational
IsepamicinMesalazine may decrease the excretion rate of Isepamicin which could result in a higher serum level.Experimental
IsoxicamThe risk or severity of adverse effects can be increased when Isoxicam is combined with Mesalazine.Withdrawn
IstaroximeThe risk or severity of adverse effects can be increased when Mesalazine is combined with Istaroxime.Investigational
KanamycinMesalazine may decrease the excretion rate of Kanamycin which could result in a higher serum level.Approved, Investigational, Vet Approved
KebuzoneThe risk or severity of adverse effects can be increased when Kebuzone is combined with Mesalazine.Experimental
KetanserinThe risk or severity of adverse effects can be increased when Ketanserin is combined with Mesalazine.Investigational
KetoprofenThe risk or severity of adverse effects can be increased when Mesalazine is combined with Ketoprofen.Approved, Vet Approved
KetorolacThe risk or severity of adverse effects can be increased when Ketorolac is combined with Mesalazine.Approved
LabetalolMesalazine may decrease the antihypertensive activities of Labetalol.Approved
LafutidineThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Lafutidine.Investigational
Lanatoside CThe serum concentration of Lanatoside C can be decreased when it is combined with Mesalazine.Experimental
LandiololMesalazine may decrease the antihypertensive activities of Landiolol.Investigational
LansoprazoleThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Lansoprazole.Approved, Investigational
LatanoprostThe therapeutic efficacy of Latanoprost can be decreased when used in combination with Mesalazine.Approved, Investigational
Latanoprostene BunodThe therapeutic efficacy of Latanoprostene Bunod can be decreased when used in combination with Mesalazine.Approved, Investigational
LavoltidineThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Lavoltidine.Investigational
LeflunomideThe risk or severity of adverse effects can be increased when Leflunomide is combined with Mesalazine.Approved, Investigational
LepirudinMesalazine may increase the anticoagulant activities of Lepirudin.Approved
LetaxabanMesalazine may increase the anticoagulant activities of Letaxaban.Investigational
LevobetaxololMesalazine may decrease the antihypertensive activities of Levobetaxolol.Approved, Investigational
LevobunololMesalazine may decrease the antihypertensive activities of Levobunolol.Approved
LevofloxacinMesalazine may increase the neuroexcitatory activities of Levofloxacin.Approved, Investigational
LevomilnacipranLevomilnacipran may increase the antiplatelet activities of Mesalazine.Approved, Investigational
LimaprostThe therapeutic efficacy of Limaprost can be decreased when used in combination with Mesalazine.Approved, Investigational
LinsidomineThe risk or severity of adverse effects can be increased when Linsidomine is combined with Mesalazine.Experimental
LiraglutideMesalazine may increase the hypoglycemic activities of Liraglutide.Approved
LisinoprilThe therapeutic efficacy of Lisinopril can be decreased when used in combination with Mesalazine.Approved, Investigational
LisofyllineThe risk or severity of adverse effects can be increased when Lisofylline is combined with Mesalazine.Investigational
LithiumThe serum concentration of Lithium can be increased when it is combined with Mesalazine.Approved
LomefloxacinMesalazine may increase the neuroexcitatory activities of Lomefloxacin.Approved, Investigational
LonazolacThe risk or severity of adverse effects can be increased when Lonazolac is combined with Mesalazine.Experimental
LornoxicamThe risk or severity of adverse effects can be increased when Mesalazine is combined with Lornoxicam.Approved, Investigational
LosartanThe risk or severity of adverse effects can be increased when Losartan is combined with Mesalazine.Approved
LoteprednolThe risk or severity of adverse effects can be increased when Mesalazine is combined with Loteprednol.Approved
LoxoprofenThe risk or severity of adverse effects can be increased when Loxoprofen is combined with Mesalazine.Approved, Investigational
LubiprostoneThe therapeutic efficacy of Lubiprostone can be decreased when used in combination with Mesalazine.Approved, Investigational
LumiracoxibThe risk or severity of adverse effects can be increased when Mesalazine is combined with Lumiracoxib.Approved, Investigational
LuprostiolThe therapeutic efficacy of Luprostiol can be decreased when used in combination with Mesalazine.Vet Approved
MagaldrateThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Magaldrate.Approved, Withdrawn
Magnesium carbonateThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Magnesium carbonate.Approved, Investigational
Magnesium hydroxideThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Magnesium hydroxide.Approved, Investigational
Magnesium oxideThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Magnesium oxide.Approved
Magnesium peroxideThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Magnesium peroxide.Experimental
Magnesium salicylateThe risk or severity of adverse effects can be increased when Mesalazine is combined with Magnesium salicylate.Approved
Magnesium silicateThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Magnesium silicate.Approved
Magnesium TrisilicateThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Magnesium Trisilicate.Approved
MasoprocolThe risk or severity of adverse effects can be increased when Masoprocol is combined with Mesalazine.Approved, Investigational
ME-609The risk or severity of adverse effects can be increased when Mesalazine is combined with ME-609.Investigational
MecaserminMesalazine may increase the hypoglycemic activities of Mecasermin.Approved, Investigational
Meclofenamic acidThe risk or severity of adverse effects can be increased when Mesalazine is combined with Meclofenamic acid.Approved, Vet Approved
MedrysoneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Medrysone.Approved
Mefenamic acidThe risk or severity of adverse effects can be increased when Mesalazine is combined with Mefenamic acid.Approved
MelagatranMesalazine may increase the anticoagulant activities of Melagatran.Experimental
MelengestrolThe risk or severity of adverse effects can be increased when Mesalazine is combined with Melengestrol.Vet Approved
MeloxicamThe risk or severity of adverse effects can be increased when Mesalazine is combined with Meloxicam.Approved, Vet Approved
MepindololMesalazine may decrease the antihypertensive activities of Mepindolol.Experimental
MercaptopurineThe metabolism of Mercaptopurine can be decreased when combined with Mesalazine.Approved
MestranolMesalazine may increase the thrombogenic activities of Mestranol.Approved
MetamizoleThe risk or severity of adverse effects can be increased when Metamizole is combined with Mesalazine.Approved, Investigational, Withdrawn
MetforminMesalazine may increase the hypoglycemic activities of Metformin.Approved
MethallenestrilMesalazine may increase the thrombogenic activities of Methallenestril.Experimental
MethanthelineThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Methantheline.Approved, Investigational
MethazolamideThe risk or severity of adverse effects can be increased when Mesalazine is combined with Methazolamide.Approved
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Mesalazine.Approved
MethyclothiazideThe therapeutic efficacy of Methyclothiazide can be decreased when used in combination with Mesalazine.Approved
Methyl salicylateMesalazine may increase the anticoagulant activities of Methyl salicylate.Approved, Vet Approved
MethylprednisoloneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Methylprednisolone.Approved, Vet Approved
MetiamideThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Metiamide.Experimental
MetildigoxinThe serum concentration of Metildigoxin can be decreased when it is combined with Mesalazine.Experimental
MetipranololMesalazine may decrease the antihypertensive activities of Metipranolol.Approved
MetolazoneThe therapeutic efficacy of Metolazone can be decreased when used in combination with Mesalazine.Approved
MetoprololMesalazine may decrease the antihypertensive activities of Metoprolol.Approved, Investigational
MicronomicinMesalazine may decrease the excretion rate of Micronomicin which could result in a higher serum level.Experimental
MifamurtideThe therapeutic efficacy of Mifamurtide can be decreased when used in combination with Mesalazine.Approved, Experimental
MifepristoneMesalazine may increase the hypoglycemic activities of Mifepristone.Approved, Investigational
MiglitolMesalazine may increase the hypoglycemic activities of Miglitol.Approved
MilnacipranMilnacipran may increase the antiplatelet activities of Mesalazine.Approved, Investigational
MilrinoneThe risk or severity of adverse effects can be increased when Milrinone is combined with Mesalazine.Approved
MisoprostolThe therapeutic efficacy of Misoprostol can be decreased when used in combination with Mesalazine.Approved
MizoribineThe risk or severity of adverse effects can be increased when Mizoribine is combined with Mesalazine.Investigational
MoexiprilThe therapeutic efficacy of Moexipril can be decreased when used in combination with Mesalazine.Approved
MofebutazoneThe risk or severity of adverse effects can be increased when Mofebutazone is combined with Mesalazine.Experimental
MometasoneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Mometasone.Approved, Vet Approved
MorniflumateThe risk or severity of adverse effects can be increased when Morniflumate is combined with Mesalazine.Approved
MoxestrolMesalazine may increase the thrombogenic activities of Moxestrol.Experimental
MoxifloxacinMesalazine may increase the neuroexcitatory activities of Moxifloxacin.Approved, Investigational
Mycophenolate mofetilThe risk or severity of adverse effects can be increased when Mycophenolate mofetil is combined with Mesalazine.Approved, Investigational
Mycophenolic acidThe risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Mesalazine.Approved
NabumetoneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Nabumetone.Approved
NadololMesalazine may decrease the antihypertensive activities of Nadolol.Approved
NadroparinMesalazine may increase the anticoagulant activities of Nadroparin.Approved, Investigational
NafamostatThe risk or severity of adverse effects can be increased when Nafamostat is combined with Mesalazine.Approved, Investigational
NaftifineThe risk or severity of adverse effects can be increased when Naftifine is combined with Mesalazine.Approved
NaftopidilThe risk or severity of adverse effects can be increased when Naftopidil is combined with Mesalazine.Investigational
Nalidixic AcidMesalazine may increase the neuroexcitatory activities of Nalidixic Acid.Approved, Investigational
NaproxenThe risk or severity of adverse effects can be increased when Mesalazine is combined with Naproxen.Approved, Vet Approved
NateglinideMesalazine may increase the hypoglycemic activities of Nateglinide.Approved, Investigational
NCX 1022The risk or severity of adverse effects can be increased when Mesalazine is combined with NCX 1022.Investigational
NeamineMesalazine may decrease the excretion rate of Neamine which could result in a higher serum level.Experimental
NebivololMesalazine may decrease the antihypertensive activities of Nebivolol.Approved, Investigational
NefazodoneNefazodone may increase the antiplatelet activities of Mesalazine.Approved, Withdrawn
NemonoxacinMesalazine may increase the neuroexcitatory activities of Nemonoxacin.Investigational
NeomycinMesalazine may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Vet Approved
NepafenacThe risk or severity of adverse effects can be increased when Nepafenac is combined with Mesalazine.Approved, Investigational
NetilmicinMesalazine may decrease the excretion rate of Netilmicin which could result in a higher serum level.Approved, Investigational
NifenazoneThe risk or severity of adverse effects can be increased when Nifenazone is combined with Mesalazine.Experimental
Niflumic AcidThe risk or severity of adverse effects can be increased when Mesalazine is combined with Niflumic Acid.Approved
NimesulideThe risk or severity of adverse effects can be increased when Mesalazine is combined with Nimesulide.Approved, Investigational, Withdrawn
NiperotidineThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Niperotidine.Experimental, Investigational
NitroaspirinThe risk or severity of adverse effects can be increased when Nitroaspirin is combined with Mesalazine.Investigational
NizatidineThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Nizatidine.Approved
NorfloxacinMesalazine may increase the neuroexcitatory activities of Norfloxacin.Approved
OfloxacinMesalazine may increase the neuroexcitatory activities of Ofloxacin.Approved
OlanzapineThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Olanzapine.Approved, Investigational
OleandrinThe serum concentration of Oleandrin can be decreased when it is combined with Mesalazine.Experimental, Investigational
Oleoyl-estroneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Oleoyl-estrone.Investigational
OlmesartanThe risk or severity of adverse effects can be increased when Olmesartan is combined with Mesalazine.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Olopatadine is combined with Mesalazine.Approved
OlsalazineThe risk or severity of adverse effects can be increased when Olsalazine is combined with Mesalazine.Approved
Omacetaxine mepesuccinateThe risk or severity of bleeding can be increased when Mesalazine is combined with Omacetaxine mepesuccinate.Approved, Investigational
OmapatrilatThe therapeutic efficacy of Omapatrilat can be decreased when used in combination with Mesalazine.Investigational
OmeprazoleThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Omeprazole.Approved, Investigational, Vet Approved
OrgoteinThe risk or severity of adverse effects can be increased when Orgotein is combined with Mesalazine.Vet Approved
OtamixabanMesalazine may increase the anticoagulant activities of Otamixaban.Investigational
OuabainThe serum concentration of Ouabain can be decreased when it is combined with Mesalazine.Approved
OxaprozinThe risk or severity of adverse effects can be increased when Mesalazine is combined with Oxaprozin.Approved
Oxolinic acidMesalazine may increase the neuroexcitatory activities of Oxolinic acid.Experimental
OxprenololMesalazine may decrease the antihypertensive activities of Oxprenolol.Approved
OxyphenbutazoneThe risk or severity of adverse effects can be increased when Oxyphenbutazone is combined with Mesalazine.Approved, Withdrawn
OzagrelThe risk or severity of adverse effects can be increased when Mesalazine is combined with Ozagrel.Investigational
PalmidrolThe risk or severity of adverse effects can be increased when Palmidrol is combined with Mesalazine.Experimental, Nutraceutical
PamidronateThe risk or severity of adverse effects can be increased when Mesalazine is combined with Pamidronate.Approved
PantoprazoleThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Pantoprazole.Approved
ParamethasoneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Paramethasone.Approved
ParecoxibThe risk or severity of adverse effects can be increased when Mesalazine is combined with Parecoxib.Approved
ParnaparinThe risk or severity of adverse effects can be increased when Mesalazine is combined with Parnaparin.Approved, Investigational
ParomomycinMesalazine may decrease the excretion rate of Paromomycin which could result in a higher serum level.Approved, Investigational
ParoxetineParoxetine may increase the antiplatelet activities of Mesalazine.Approved, Investigational
ParthenolideThe risk or severity of adverse effects can be increased when Parthenolide is combined with Mesalazine.Approved, Investigational
PazufloxacinMesalazine may increase the neuroexcitatory activities of Pazufloxacin.Investigational
PefloxacinMesalazine may increase the neuroexcitatory activities of Pefloxacin.Approved
PenbutololMesalazine may decrease the antihypertensive activities of Penbutolol.Approved, Investigational
Pentaerythritol TetranitrateMesalazine may increase the anticoagulant activities of Pentaerythritol Tetranitrate.Approved
PentamidineMesalazine may increase the hypoglycemic activities of Pentamidine.Approved, Investigational
Pentosan PolysulfateMesalazine may increase the anticoagulant activities of Pentosan Polysulfate.Approved
PentoxifyllineThe risk or severity of adverse effects can be increased when Pentoxifylline is combined with Mesalazine.Approved, Investigational
PerindoprilThe therapeutic efficacy of Perindopril can be decreased when used in combination with Mesalazine.Approved
PeruvosideThe serum concentration of Peruvoside can be decreased when it is combined with Mesalazine.Experimental
PhenindioneMesalazine may increase the anticoagulant activities of Phenindione.Approved, Investigational
PhenprocoumonMesalazine may increase the anticoagulant activities of Phenprocoumon.Approved, Investigational
Phenyl aminosalicylateMesalazine may increase the anticoagulant activities of Phenyl aminosalicylate.Approved
PhenylbutazoneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Phenylbutazone.Approved, Vet Approved
PicotamideThe risk or severity of adverse effects can be increased when Picotamide is combined with Mesalazine.Experimental
PimecrolimusThe risk or severity of adverse effects can be increased when Pimecrolimus is combined with Mesalazine.Approved, Investigational
PindololMesalazine may decrease the antihypertensive activities of Pindolol.Approved, Investigational
PioglitazoneMesalazine may increase the hypoglycemic activities of Pioglitazone.Approved, Investigational
Pipemidic acidMesalazine may increase the neuroexcitatory activities of Pipemidic acid.Experimental
PiretanideThe therapeutic efficacy of Piretanide can be decreased when used in combination with Mesalazine.Approved
PirfenidoneThe risk or severity of adverse effects can be increased when Pirfenidone is combined with Mesalazine.Approved, Investigational
Piromidic acidMesalazine may increase the neuroexcitatory activities of Piromidic acid.Experimental
PiroxicamThe risk or severity of adverse effects can be increased when Mesalazine is combined with Piroxicam.Approved, Investigational
PirprofenThe risk or severity of adverse effects can be increased when Pirprofen is combined with Mesalazine.Experimental
PitolisantThe risk or severity of adverse effects can be increased when Mesalazine is combined with Pitolisant.Approved, Investigational
Platelet Activating FactorMesalazine may decrease the antihypertensive activities of Platelet Activating Factor.Experimental
PlazomicinMesalazine may decrease the excretion rate of Plazomicin which could result in a higher serum level.Investigational
Polyestradiol phosphateMesalazine may increase the thrombogenic activities of Polyestradiol phosphate.Approved
PolythiazideThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Mesalazine.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Mesalazine is combined with Pomalidomide.Approved
Potassium CitrateMesalazine may increase the anticoagulant activities of Potassium Citrate.Approved, Investigational, Vet Approved
PractololMesalazine may decrease the antihypertensive activities of Practolol.Approved
PralatrexateThe serum concentration of Pralatrexate can be increased when it is combined with Mesalazine.Approved, Investigational
PramlintideMesalazine may increase the hypoglycemic activities of Pramlintide.Approved, Investigational
PranoprofenThe risk or severity of adverse effects can be increased when Pranoprofen is combined with Mesalazine.Experimental, Investigational
PrasteroneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Prasterone.Approved, Investigational, Nutraceutical
Prasterone sulfateThe risk or severity of adverse effects can be increased when Mesalazine is combined with Prasterone sulfate.Investigational
PrasugrelThe risk or severity of adverse effects can be increased when Prasugrel is combined with Mesalazine.Approved
PrednicarbateThe risk or severity of adverse effects can be increased when Mesalazine is combined with Prednicarbate.Approved, Investigational
PrednisoloneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Prednisolone.Approved, Vet Approved
PrednisoneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Prednisone.Approved, Vet Approved
PregnenoloneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Pregnenolone.Approved, Experimental, Investigational
ProbenecidThe therapeutic efficacy of Probenecid can be decreased when used in combination with Mesalazine.Approved, Investigational
ProglumetacinThe risk or severity of adverse effects can be increased when Proglumetacin is combined with Mesalazine.Experimental
PromestrieneMesalazine may increase the thrombogenic activities of Promestriene.Investigational
PromethazineThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Promethazine.Approved, Investigational
PropacetamolThe risk or severity of adverse effects can be increased when Propacetamol is combined with Mesalazine.Approved, Investigational
PropafenoneMesalazine may decrease the antihypertensive activities of Propafenone.Approved
PropranololMesalazine may decrease the antihypertensive activities of Propranolol.Approved, Investigational
PropyphenazoneThe risk or severity of adverse effects can be increased when Propyphenazone is combined with Mesalazine.Experimental
ProquazoneThe risk or severity of adverse effects can be increased when Proquazone is combined with Mesalazine.Experimental
ProscillaridinThe serum concentration of Proscillaridin can be decreased when it is combined with Mesalazine.Experimental
Prostaglandin B2The therapeutic efficacy of Prostaglandin B2 can be decreased when used in combination with Mesalazine.Experimental
Prostaglandin G2The therapeutic efficacy of Prostaglandin G2 can be decreased when used in combination with Mesalazine.Experimental
ProstaleneThe therapeutic efficacy of Prostalene can be decreased when used in combination with Mesalazine.Vet Approved
Protein CMesalazine may increase the anticoagulant activities of Protein C.Approved
Protein S humanMesalazine may increase the anticoagulant activities of Protein S human.Approved
ProtocatechualdehydeMesalazine may increase the anticoagulant activities of Protocatechualdehyde.Approved
PrulifloxacinMesalazine may increase the neuroexcitatory activities of Prulifloxacin.Investigational
PTC299The risk or severity of adverse effects can be increased when PTC299 is combined with Mesalazine.Investigational
PuromycinMesalazine may decrease the excretion rate of Puromycin which could result in a higher serum level.Experimental
QuinaprilThe therapeutic efficacy of Quinapril can be decreased when used in combination with Mesalazine.Approved, Investigational
QuinestrolMesalazine may increase the thrombogenic activities of Quinestrol.Approved
QuinethazoneThe therapeutic efficacy of Quinethazone can be decreased when used in combination with Mesalazine.Approved
QuinineMesalazine may increase the hypoglycemic activities of Quinine.Approved
RabeprazoleThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Rabeprazole.Approved, Investigational
RamatrobanThe risk or severity of adverse effects can be increased when Ramatroban is combined with Mesalazine.Investigational
RamiprilThe therapeutic efficacy of Ramipril can be decreased when used in combination with Mesalazine.Approved
RanitidineThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Ranitidine.Approved
RelcovaptanThe risk or severity of adverse effects can be increased when Relcovaptan is combined with Mesalazine.Investigational
RepaglinideMesalazine may increase the hypoglycemic activities of Repaglinide.Approved, Investigational
RescinnamineThe therapeutic efficacy of Rescinnamine can be decreased when used in combination with Mesalazine.Approved
ResveratrolThe risk or severity of adverse effects can be increased when Mesalazine is combined with Resveratrol.Approved, Experimental, Investigational
ReteplaseThe risk or severity of adverse effects can be increased when Mesalazine is combined with Reteplase.Approved, Investigational
ReviparinMesalazine may increase the anticoagulant activities of Reviparin.Approved, Investigational
RibostamycinMesalazine may decrease the excretion rate of Ribostamycin which could result in a higher serum level.Approved, Investigational
RidogrelThe risk or severity of adverse effects can be increased when Ridogrel is combined with Mesalazine.Approved
RimexoloneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Rimexolone.Approved
RisedronateThe risk or severity of adverse effects can be increased when Mesalazine is combined with Risedronate.Approved, Investigational
RivaroxabanMesalazine may increase the anticoagulant activities of Rivaroxaban.Approved
RofecoxibThe risk or severity of adverse effects can be increased when Mesalazine is combined with Rofecoxib.Approved, Investigational, Withdrawn
RosiglitazoneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Rosiglitazone.Approved, Investigational
RosoxacinMesalazine may increase the neuroexcitatory activities of Rosoxacin.Approved, Investigational
Roxatidine acetateThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Roxatidine acetate.Approved, Investigational
RufloxacinMesalazine may increase the neuroexcitatory activities of Rufloxacin.Experimental
SacubitrilThe risk or severity of adverse effects can be increased when Sacubitril is combined with Mesalazine.Approved
SalicylamideThe risk or severity of adverse effects can be increased when Salicylamide is combined with Mesalazine.Approved
Salicylic acidThe risk or severity of adverse effects can be increased when Mesalazine is combined with Salicylic acid.Approved, Investigational, Vet Approved
SalsalateThe risk or severity of adverse effects can be increased when Mesalazine is combined with Salsalate.Approved
SaprisartanThe risk or severity of adverse effects can be increased when Saprisartan is combined with Mesalazine.Experimental
SaralasinThe risk or severity of adverse effects can be increased when Saralasin is combined with Mesalazine.Investigational
SarilumabSarilumab may increase the immunosuppressive activities of Mesalazine.Approved, Investigational
SarpogrelateThe risk or severity of adverse effects can be increased when Sarpogrelate is combined with Mesalazine.Investigational
SaruplaseThe risk or severity of adverse effects can be increased when Mesalazine is combined with Saruplase.Experimental
SaxagliptinMesalazine may increase the hypoglycemic activities of Saxagliptin.Approved
SecoisolariciresinolMesalazine may increase the thrombogenic activities of Secoisolariciresinol.Investigational
SelexipagThe risk or severity of adverse effects can be increased when Mesalazine is combined with Selexipag.Approved
SeliciclibThe risk or severity of adverse effects can be increased when Mesalazine is combined with Seliciclib.Investigational
SemapimodThe risk or severity of adverse effects can be increased when Semapimod is combined with Mesalazine.Investigational
SeratrodastThe risk or severity of adverse effects can be increased when Seratrodast is combined with Mesalazine.Approved
SerrapeptaseThe risk or severity of adverse effects can be increased when Serrapeptase is combined with Mesalazine.Investigational
SertralineSertraline may increase the antiplatelet activities of Mesalazine.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Mesalazine.Approved, Vet Approved
SisomicinMesalazine may decrease the excretion rate of Sisomicin which could result in a higher serum level.Investigational
SitafloxacinMesalazine may increase the neuroexcitatory activities of Sitafloxacin.Experimental, Investigational
SitagliptinMesalazine may increase the hypoglycemic activities of Sitagliptin.Approved, Investigational
Sodium bicarbonateThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Sodium bicarbonate.Approved
Sodium CitrateMesalazine may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
Sodium phosphateSodium phosphate may increase the nephrotoxic activities of Mesalazine.Approved
SotalolMesalazine may decrease the antihypertensive activities of Sotalol.Approved
SparfloxacinMesalazine may increase the neuroexcitatory activities of Sparfloxacin.Approved, Investigational
SpiraprilThe therapeutic efficacy of Spirapril can be decreased when used in combination with Mesalazine.Approved
SpironolactoneMesalazine may decrease the antihypertensive activities of Spironolactone.Approved
SRT501The risk or severity of adverse effects can be increased when SRT501 is combined with Mesalazine.Investigational
StreptokinaseThe risk or severity of adverse effects can be increased when Mesalazine is combined with Streptokinase.Approved, Investigational
StreptomycinMesalazine may decrease the excretion rate of Streptomycin which could result in a higher serum level.Approved, Vet Approved
SulfadiazineMesalazine may increase the hypoglycemic activities of Sulfadiazine.Approved, Investigational, Vet Approved
SulfamethoxazoleMesalazine may increase the hypoglycemic activities of Sulfamethoxazole.Approved
SulfasalazineThe risk or severity of adverse effects can be increased when Mesalazine is combined with Sulfasalazine.Approved
SulfisoxazoleMesalazine may increase the hypoglycemic activities of Sulfisoxazole.Approved, Vet Approved
SulindacThe risk or severity of adverse effects can be increased when Mesalazine is combined with Sulindac.Approved, Investigational
SulodexideMesalazine may increase the anticoagulant activities of Sulodexide.Approved, Investigational
SulprostoneThe therapeutic efficacy of Sulprostone can be decreased when used in combination with Mesalazine.Investigational
SunitinibMesalazine may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
SuprofenThe risk or severity of adverse effects can be increased when Mesalazine is combined with Suprofen.Approved, Withdrawn
SuxibuzoneThe risk or severity of adverse effects can be increased when Suxibuzone is combined with Mesalazine.Experimental
Synthetic Conjugated Estrogens, AMesalazine may increase the thrombogenic activities of Synthetic Conjugated Estrogens, A.Approved
Synthetic Conjugated Estrogens, BMesalazine may increase the thrombogenic activities of Synthetic Conjugated Estrogens, B.Approved
TacrolimusMesalazine may increase the nephrotoxic activities of Tacrolimus.Approved, Investigational
TafluprostThe therapeutic efficacy of Tafluprost can be decreased when used in combination with Mesalazine.Approved
TalinololMesalazine may decrease the antihypertensive activities of Talinolol.Investigational
TalniflumateThe risk or severity of adverse effects can be increased when Talniflumate is combined with Mesalazine.Approved
TarenflurbilThe risk or severity of adverse effects can be increased when Tarenflurbil is combined with Mesalazine.Investigational
TasosartanThe risk or severity of adverse effects can be increased when Tasosartan is combined with Mesalazine.Approved
Technetium Tc-99m etidronateThe risk or severity of adverse effects can be increased when Mesalazine is combined with Technetium Tc-99m etidronate.Approved
Technetium Tc-99m medronateThe risk or severity of adverse effects can be increased when Mesalazine is combined with Technetium Tc-99m medronate.Approved
TelmisartanThe risk or severity of adverse effects can be increased when Telmisartan is combined with Mesalazine.Approved, Investigational
TemafloxacinMesalazine may increase the neuroexcitatory activities of Temafloxacin.Withdrawn
TemocaprilThe therapeutic efficacy of Temocapril can be decreased when used in combination with Mesalazine.Experimental, Investigational
TenecteplaseThe risk or severity of adverse effects can be increased when Mesalazine is combined with Tenecteplase.Approved
TenidapThe risk or severity of adverse effects can be increased when Tenidap is combined with Mesalazine.Experimental
Tenofovir disoproxilThe risk or severity of adverse effects can be increased when Mesalazine is combined with Tenofovir disoproxil.Approved, Investigational
TenoxicamThe risk or severity of adverse effects can be increased when Mesalazine is combined with Tenoxicam.Approved
TepoxalinThe risk or severity of adverse effects can be increased when Tepoxalin is combined with Mesalazine.Vet Approved
TerbutalineMesalazine may decrease the antihypertensive activities of Terbutaline.Approved
TeriflunomideThe risk or severity of adverse effects can be increased when Teriflunomide is combined with Mesalazine.Approved
TertatololMesalazine may decrease the antihypertensive activities of Tertatolol.Experimental
TesmilifeneThe risk or severity of adverse effects can be increased when Tesmilifene is combined with Mesalazine.Investigational
Tiaprofenic acidThe risk or severity of adverse effects can be increased when Mesalazine is combined with Tiaprofenic acid.Approved
TiboloneMesalazine may increase the thrombogenic activities of Tibolone.Approved, Investigational
TicagrelorThe risk or severity of adverse effects can be increased when Mesalazine is combined with Ticagrelor.Approved
TiclopidineThe risk or severity of adverse effects can be increased when Ticlopidine is combined with Mesalazine.Approved
Tiludronic acidThe risk or severity of adverse effects can be increased when Mesalazine is combined with Tiludronic acid.Approved, Investigational, Vet Approved
TimololMesalazine may decrease the antihypertensive activities of Timolol.Approved
TinoridineThe risk or severity of adverse effects can be increased when Tinoridine is combined with Mesalazine.Investigational
TinzaparinThe risk or severity of adverse effects can be increased when Mesalazine is combined with Tinzaparin.Approved
TioclomarolMesalazine may increase the anticoagulant activities of Tioclomarol.Experimental
TioguanineThe metabolism of Tioguanine can be decreased when combined with Mesalazine.Approved
TirofibanThe risk or severity of adverse effects can be increased when Tirofiban is combined with Mesalazine.Approved
TixocortolThe risk or severity of adverse effects can be increased when Mesalazine is combined with Tixocortol.Approved, Withdrawn
TobramycinMesalazine may decrease the excretion rate of Tobramycin which could result in a higher serum level.Approved, Investigational
TolazamideMesalazine may increase the hypoglycemic activities of Tolazamide.Approved, Investigational
TolbutamideMesalazine may increase the hypoglycemic activities of Tolbutamide.Approved, Investigational
Tolfenamic AcidThe risk or severity of adverse effects can be increased when Tolfenamic Acid is combined with Mesalazine.Approved, Investigational
TolmetinThe risk or severity of adverse effects can be increased when Mesalazine is combined with Tolmetin.Approved
TorasemideThe therapeutic efficacy of Torasemide can be decreased when used in combination with Mesalazine.Approved
TrandolaprilThe therapeutic efficacy of Trandolapril can be decreased when used in combination with Mesalazine.Approved
TranilastThe risk or severity of adverse effects can be increased when Tranilast is combined with Mesalazine.Approved, Investigational
TrapidilThe risk or severity of adverse effects can be increased when Trapidil is combined with Mesalazine.Approved
TravoprostThe therapeutic efficacy of Travoprost can be decreased when used in combination with Mesalazine.Approved
TreprostinilThe risk or severity of adverse effects can be increased when Treprostinil is combined with Mesalazine.Approved, Investigational
TriamcinoloneThe risk or severity of adverse effects can be increased when Mesalazine is combined with Triamcinolone.Approved, Vet Approved
TriamtereneMesalazine may decrease the antihypertensive activities of Triamterene.Approved
TribenosideThe risk or severity of adverse effects can be increased when Tribenoside is combined with Mesalazine.Experimental
TrichlormethiazideThe therapeutic efficacy of Trichlormethiazide can be decreased when used in combination with Mesalazine.Approved, Vet Approved
TriflusalThe risk or severity of adverse effects can be increased when Triflusal is combined with Mesalazine.Approved, Investigational
TriptolideThe risk or severity of adverse effects can be increased when Triptolide is combined with Mesalazine.Investigational
Trolamine salicylateThe risk or severity of adverse effects can be increased when Mesalazine is combined with Trolamine salicylate.Approved
TromethamineThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Tromethamine.Approved
TrovafloxacinMesalazine may increase the neuroexcitatory activities of Trovafloxacin.Approved, Investigational, Withdrawn
TroxerutinMesalazine may increase the anticoagulant activities of Troxerutin.Investigational
UlobetasolThe risk or severity of adverse effects can be increased when Mesalazine is combined with Ulobetasol.Approved
UnoprostoneThe therapeutic efficacy of Unoprostone can be decreased when used in combination with Mesalazine.Approved, Investigational
UrokinaseThe risk or severity of adverse effects can be increased when Mesalazine is combined with Urokinase.Approved, Investigational, Withdrawn
ValdecoxibThe risk or severity of adverse effects can be increased when Mesalazine is combined with Valdecoxib.Approved, Investigational, Withdrawn
Valproic AcidThe serum concentration of Valproic Acid can be increased when it is combined with Mesalazine.Approved, Investigational
ValsartanThe risk or severity of adverse effects can be increased when Valsartan is combined with Mesalazine.Approved, Investigational
VancomycinThe serum concentration of Vancomycin can be increased when it is combined with Mesalazine.Approved
VenlafaxineVenlafaxine may increase the antiplatelet activities of Mesalazine.Approved
VerapamilVerapamil may increase the anticoagulant activities of Mesalazine.Approved
VorapaxarThe risk or severity of adverse effects can be increased when Vorapaxar is combined with Mesalazine.Approved
WarfarinMesalazine may increase the anticoagulant activities of Warfarin.Approved
XimelagatranMesalazine may increase the anticoagulant activities of Ximelagatran.Approved, Investigational, Withdrawn
ZaltoprofenThe risk or severity of adverse effects can be increased when Zaltoprofen is combined with Mesalazine.Approved, Investigational
ZeranolMesalazine may increase the thrombogenic activities of Zeranol.Vet Approved
ZileutonThe risk or severity of adverse effects can be increased when Zileuton is combined with Mesalazine.Approved, Investigational, Withdrawn
ZimelidineZimelidine may increase the antiplatelet activities of Mesalazine.Withdrawn
ZofenoprilThe therapeutic efficacy of Zofenopril can be decreased when used in combination with Mesalazine.Experimental
Zoledronic acidThe risk or severity of adverse effects can be increased when Mesalazine is combined with Zoledronic acid.Approved
ZomepiracThe risk or severity of adverse effects can be increased when Zomepirac is combined with Mesalazine.Withdrawn
Food Interactions
  • Take without regard to meals.

References

Synthesis Reference

Thomas M. Parkinson, Joseph P. Brown, Robert E. Wingard, Jr., "Pharmaceutical preparations containing a polymeric agent for releasing 5-aminosalicylic acid or its salts into the gastrointestinal tract." U.S. Patent US4298595, issued January, 1975.

US4298595
General References
  1. Link [Link]
External Links
Human Metabolome Database
HMDB0014389
KEGG Drug
D00377
PubChem Compound
4075
PubChem Substance
46509142
ChemSpider
3933
BindingDB
60918
ChEBI
6775
ChEMBL
CHEMBL704
Therapeutic Targets Database
DAP000729
PharmGKB
PA450384
IUPHAR
2700
Guide to Pharmacology
GtP Drug Page
RxList
RxList Drug Page
PDRhealth
PDRhealth Drug Page
Wikipedia
Mesalazine
ATC Codes
A07EC02 — Mesalazine
AHFS Codes
  • 56:36.00 — Anti-inflammatory Agents
MSDS
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Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedNot AvailableHealthy Volunteers4
1CompletedNot AvailableUlcerative Colitis (UC)1
1CompletedBasic ScienceHealthy Volunteers1
1CompletedBasic ScienceUlcerative Colitis (UC)3
1CompletedTreatmentHealthy Volunteers4
1CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections1
1CompletedTreatmentUlcerative Colitis (UC)1
1TerminatedNot AvailableUlcerative Colitis (UC)1
1, 2Active Not RecruitingTreatmentHelminth Infection / Protozoan Infections / Ulcerative Colitis (UC) / Ulcerative Colitis Exacerbation1
1, 2CompletedTreatmentChronic Beryllium Disease (CBD)1
1, 2CompletedTreatmentMalnutrition1
2CompletedPreventionSporadic Colorectal Adenoma1
2CompletedTreatmentColorectal Cancers1
2CompletedTreatmentDiverticulitis1
2CompletedTreatmentDiverticulosis, Colonic1
2CompletedTreatmentIrritable Bowel Syndrome (IBS)2
2CompletedTreatmentProctitis1
2CompletedTreatmentUlcerative Colitis (UC)2
2Not Yet RecruitingPreventionColorectal Cancers1
2Not Yet RecruitingPreventionColorectal Neoplasms, Hereditary Nonpolyposis1
2RecruitingTreatmentCrohn's Disease (CD) / Inflammatory Bowel Diseases (IBD) / Ulcerative Colitis (UC)1
2WithdrawnTreatmentColitis / Cytokines / Drug Evaluation / Hermanski-Pudlak Syndrome / Lymphocytes1
2, 3CompletedTreatmentDiarrhea / Microscopic Colitis1
2, 3CompletedTreatmentIrritable Bowel Syndrome (IBS)1
2, 3RecruitingTreatmentCrohn's Disease (CD) / Inflammatory Bowel Diseases (IBD)1
3CompletedNot AvailableMild to Moderate Ulcerative Colitis1
3CompletedPreventionCrohn's Disease (CD)1
3CompletedPreventionDiverticular disorders1
3CompletedPreventionDiverticulitis2
3CompletedPreventionRecurrences / Ulcerative Colitis (UC)1
3CompletedPreventionUlcerative Colitis (UC)2
3CompletedTreatmentActive Ulcerative Colitis1
3CompletedTreatmentActive Ulcerative Colitis / Remission of Ulcerative Colitis1
3CompletedTreatmentAcute Ulcerative Colitis1
3CompletedTreatmentCollagenous Colitis1
3CompletedTreatmentCrohn's Disease (CD)2
3CompletedTreatmentIrritable Bowel Syndrome (IBS)1
3CompletedTreatmentLymphocytic Colitis1
3CompletedTreatmentUlcerative Colitis (UC)18
3CompletedTreatmentUlcerative Colitis in Remission1
3RecruitingTreatmentCrohn's Disease (CD) / Oral Ulcers1
3RecruitingTreatmentIrritable Bowel Syndrome (IBS)1
3RecruitingTreatmentUlcerative Colitis (UC)8
3TerminatedPreventionDiverticulitis2
3TerminatedTreatmentCrohn's Disease (CD)2
3TerminatedTreatmentProctitis1
3TerminatedTreatmentUlcerative Colitis (UC)2
3TerminatedTreatmentUlcerative Proctitis1
4Active Not RecruitingTreatmentUlcerative Colitis (UC)1
4CompletedDiagnosticUlcerative Colitis (UC)1
4CompletedPreventionUlcerative Colitis (UC)1
4CompletedTreatmentAcquired Immune Deficiency Syndrome (AIDS) / Human Immunodeficiency Virus (HIV) Infections / Immune System Diseases / Lentivirus Infections / Sexually Transmitted Disease (STD)1
4CompletedTreatmentCrohn's Disease (CD) / Inflammatory Bowel Diseases (IBD) / Ulcerative Colitis (UC)1
4CompletedTreatmentDiverticular Disease of the Colon1
4CompletedTreatmentIrritable Bowel Syndrome With Diarrhoea1
4CompletedTreatmentMild to Moderate Ulcerative Colitis1
4CompletedTreatmentUlcerative Colitis (UC)1
4RecruitingTreatmentCrohn's Disease (CD)1
4RecruitingTreatmentUlcerative Colitis (UC)1
4TerminatedTreatmentCrohn's Disease (CD)1
4Unknown StatusTreatmentIntestinal LNH1
4WithdrawnTreatmentDiarrhea- Predominant Irritable Bowel Syndrome / Quality of Life1
Not AvailableActive Not RecruitingNot AvailableActive Ulcerative Proctitis / Distal Ulcerative Colitis1
Not AvailableActive Not RecruitingBasic ScienceLocal Drug Concentration in Gastrointestinal Tract1
Not AvailableCompletedTreatmentHealthy Volunteers1
Not AvailableCompletedTreatmentInflammatory Bowel Diseases (IBD) / Ulcerative Colitis (UC)1
Not AvailableRecruitingNot AvailableUlcerative Colitis (UC)1
Not AvailableRecruitingSupportive CareUlcerative Colitis (UC)1
Not AvailableRecruitingTreatmentAminosalicylic Acid / Ulcerative Colitis (UC)1
Not AvailableTerminatedTreatmentUlcerative Colitis (UC)1
Not AvailableUnknown StatusNot AvailableSimple Diverticular Disease1

Pharmacoeconomics

Manufacturers
  • Salix pharmaceuticals inc
  • Shire development inc
  • Perrigo israel pharmaceuticals ltd
  • Teva pharmaceuticals usa inc
  • Alaven pharmaceutical llc
  • Axcan pharma us inc
  • Warner chilcott pharmaceuticals inc
Packagers
  • Alaven Pharmaceutical
  • Amerisource Health Services Corp.
  • Anip Acquisition Co.
  • Atlantic Biologicals Corporation
  • Axcan Pharma Inc.
  • Cardinal Health
  • Comprehensive Consultant Services Inc.
  • Cosmo SPA
  • Dept Health Central Pharmacy
  • Diversified Healthcare Services Inc.
  • Ferring Pharmaceuticals Inc.
  • Franklin Pharmaceutical LLC
  • Gavis Pharmaceuticals LLC
  • Heartland Repack Services LLC
  • Infar SA
  • Letco Medical Inc.
  • Norwich Pharmaceuticals Inc.
  • Paddock Labs
  • PD-Rx Pharmaceuticals Inc.
  • Perrigo Co.
  • Physicians Total Care Inc.
  • Prasco Labs
  • Prepak Systems Inc.
  • Resource Optimization and Innovation LLC
  • Salix Pharmaceuticals
  • Sanofi-Aventis Inc.
  • Shire Inc.
  • Solvay Pharmaceuticals
  • Teva Pharmaceutical Industries Ltd.
  • Vangard Labs Inc.
  • Warner Chilcott Co. Inc.
  • WC Pharmaceuticals
  • Wellspring Pharmaceutical
Dosage forms
FormRouteStrength
Tablet, delayed releaseOral400 mg
Capsule, extended releaseOral375 mg/1
TabletOral400 mg/1
Tablet, delayed releaseOral400 mg/1
Tablet, delayed releaseOral800 mg
SuppositoryRectal1000 mg/1
Capsule, delayed releaseOral400 mg/1
Tablet, delayed releaseOral1.2 g/1
EnemaRectal4 g/60mL
Kit
SuspensionRectal4 g/60mL
Tablet, delayed releaseOral800 mg/1
Tablet, extended releaseOral1.2 g
KitRectal1 g
CapsuleOral250 mg/1
CapsuleOral500 mg/1
SuspensionRectal1 g
SuspensionRectal4 g
Tablet, extended releaseOral1 g
Enema; liquidRectal2 g
Tablet, extended releaseOral250 mg
Tablet, extended releaseOral500 mg
SuppositoryRectal1 g
SuppositoryRectal500 mg
SuspensionRectal2 g
Tablet, delayed releaseOral500 mg
Tablet, delayed releaseOral250 mg
SuppositoryRectal250 mg
Prices
Unit descriptionCostUnit
Canasa 30 1000 mg Suppository Box488.32USD box
Canasa 1000 mg suppository13.88USD suppository
Salofalk (4 g/60 g) 4 g/enm Enema6.73USD enema
Canasa 500 mg suppository6.24USD suppository
Pentasa (4 g/100 Ml) 4 g/enm Enema5.02USD enema
Pentasa (1 g/100Ml) 1 g/enm Enema4.17USD enema
Salofalk (2 g/60 g) 2 g/enm Enema3.96USD enema
Asacol hd dr 800 mg tablet3.88USD tablet
Pentasa 500 mg capsule2.66USD capsule
Asacol 400 mg Enteric Coated Tabs2.22USD tab
Asacol ec 400 mg tablet1.94USD tablet
Salofalk 1000 mg Suppository1.81USD suppository
Pentasa 1 g Suppository1.8USD suppository
Salofalk 500 mg Suppository1.23USD suppository
Asacol 800 800 mg Enteric-Coated Tablet1.14USD tablet
Pentasa 250 mg capsule1.07USD capsule
Mesasal 500 mg Enteric-Coated Tablet0.69USD tablet
Pentasa 500 mg Sustained-Release Tablet0.63USD tablet
Asacol 400 mg Enteric-Coated Tablet0.59USD tablet
Salofalk 500 mg Enteric-Coated Tablet0.56USD tablet
Novo-5 Asa 400 mg Enteric-Coated Tablet0.42USD tablet
Rowasa 4 gm/60 ml enema0.41USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5541170No1993-07-302013-07-30Us
CA2444814No2009-06-092021-10-24Canada
CA2111697No2002-08-202012-06-16Canada
US7645801No2007-07-242027-07-24Us
US6773720No2000-06-082020-06-08Us
US8436051No2008-06-062028-06-06Us
US8217083No2008-06-062028-06-06Us
US6893662No2001-11-152021-11-15Us
US8580302No2001-11-152021-11-15Us
US9089492No2001-11-152021-11-15Us
US8911778No1998-04-202018-04-20Us
US6551620No1998-04-202018-04-20Us
US8337886No1998-04-202018-04-20Us
US8865688No2010-05-012030-05-01Us
US8496965No1998-04-202018-04-20Us
US8940328No1998-04-202018-04-20Us
US8956647No1998-04-202018-04-20Us
US6649180No2000-04-132020-04-13Us

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)283 °CPhysProp
water solubility0.84 g/L at 20°CNot Available
logP1.2Not Available
Predicted Properties
PropertyValueSource
Water Solubility12.2 mg/mLALOGPS
logP0.75ALOGPS
logP-0.29ChemAxon
logS-1.1ALOGPS
pKa (Strongest Acidic)2.02ChemAxon
pKa (Strongest Basic)5.87ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area83.55 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity40 m3·mol-1ChemAxon
Polarizability14.26 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9471
Blood Brain Barrier-0.6168
Caco-2 permeable-0.8829
P-glycoprotein substrateNon-substrate0.8186
P-glycoprotein inhibitor INon-inhibitor0.985
P-glycoprotein inhibitor IINon-inhibitor0.9912
Renal organic cation transporterNon-inhibitor0.9314
CYP450 2C9 substrateNon-substrate0.8284
CYP450 2D6 substrateNon-substrate0.8331
CYP450 3A4 substrateNon-substrate0.7636
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.8712
CYP450 2D6 inhibitorNon-inhibitor0.9744
CYP450 2C19 inhibitorInhibitor0.6752
CYP450 3A4 inhibitorNon-inhibitor0.6628
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9023
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.7922
BiodegradationReady biodegradable0.6197
Rat acute toxicity1.7065 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9759
hERG inhibition (predictor II)Non-inhibitor0.9715
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Download (8.48 KB)
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0f79-0900000000-db75ae2d436dd6156c91

Taxonomy

Description
This compound belongs to the class of organic compounds known as aminobenzoic acids. These are benzoic acids containing an amine group attached to the benzene moiety.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Benzoic acids and derivatives
Direct Parent
Aminobenzoic acids
Alternative Parents
Salicylic acids / Benzoic acids / p-Aminophenols / Benzoyl derivatives / Aniline and substituted anilines / 1-hydroxy-2-unsubstituted benzenoids / Vinylogous acids / Amino acids / Monocarboxylic acids and derivatives / Carboxylic acids
show 5 more
Substituents
Aminobenzoic acid / Hydroxybenzoic acid / Salicylic acid or derivatives / Salicylic acid / Benzoic acid / P-aminophenol / Aminophenol / Benzoyl / Aniline or substituted anilines / 1-hydroxy-2-unsubstituted benzenoid
show 17 more
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
monocarboxylic acid, phenols, aromatic amine, amino acid, monohydroxybenzoic acid (CHEBI:6775)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Prostaglandin-endoperoxide synthase activity
Specific Function
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and...
Gene Name
PTGS2
Uniprot ID
P35354
Uniprot Name
Prostaglandin G/H synthase 2
Molecular Weight
68995.625 Da
References
  1. Mifflin RC, Saada JI, Di Mari JF, Valentich JD, Adegboyega PA, Powell DW: Aspirin-mediated COX-2 transcript stabilization via sustained p38 activation in human intestinal myofibroblasts. Mol Pharmacol. 2004 Feb;65(2):470-8. [PubMed:14742690]
  2. Generini S, Fiori G, Matucci Cerinic M: Therapy of spondylarthropathy in inflammatory bowel disease. Clin Exp Rheumatol. 2002 Nov-Dec;20(6 Suppl 28):S88-94. [PubMed:12463455]
  3. Distrutti E, Sediari L, Mencarelli A, Renga B, Orlandi S, Russo G, Caliendo G, Santagada V, Cirino G, Wallace JL, Fiorucci S: 5-Amino-2-hydroxybenzoic acid 4-(5-thioxo-5H-[1,2]dithiol-3yl)-phenyl ester (ATB-429), a hydrogen sulfide-releasing derivative of mesalamine, exerts antinociceptive effects in a model of postinflammatory hypersensitivity. J Pharmacol Exp Ther. 2006 Oct;319(1):447-58. Epub 2006 Jul 19. [PubMed:16855178]
  4. Cipolla G, Crema F, Sacco S, Moro E, de Ponti F, Frigo G: Nonsteroidal anti-inflammatory drugs and inflammatory bowel disease: current perspectives. Pharmacol Res. 2002 Jul;46(1):1-6. [PubMed:12208114]
  5. Pruzanski W, Stefanski E, Vadas P, Ramamurthy NS: Inhibition of extracellular release of proinflammatory secretory phospholipase A2 (sPLA2) by sulfasalazine: a novel mechanism of anti-inflammatory activity. Biochem Pharmacol. 1997 Jun 15;53(12):1901-7. [PubMed:9256165]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Prostaglandin-endoperoxide synthase activity
Specific Function
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gas...
Gene Name
PTGS1
Uniprot ID
P23219
Uniprot Name
Prostaglandin G/H synthase 1
Molecular Weight
68685.82 Da
References
  1. Allgayer H: Review article: mechanisms of action of mesalazine in preventing colorectal carcinoma in inflammatory bowel disease. Aliment Pharmacol Ther. 2003 Sep;18 Suppl 2:10-4. [PubMed:12950415]
  2. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Iron ion binding
Specific Function
Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.
Gene Name
ALOX5
Uniprot ID
P09917
Uniprot Name
Arachidonate 5-lipoxygenase
Molecular Weight
77982.595 Da
References
  1. Nielsen OH, Bukhave K, Elmgreen J, Ahnfelt-Ronne I: Inhibition of 5-lipoxygenase pathway of arachidonic acid metabolism in human neutrophils by sulfasalazine and 5-aminosalicylic acid. Dig Dis Sci. 1987 Jun;32(6):577-82. [PubMed:2882965]
  2. Allgayer H, Eisenburg J, Paumgartner G: Soybean lipoxygenase inhibition: studies with the sulphasalazine metabolites N-acetylaminosalicylic acid, 5-aminosalicylic acid and sulphapyridine. Eur J Clin Pharmacol. 1984;26(4):449-51. [PubMed:6428914]
  3. Sircar JC, Schwender CF, Carethers ME: Inhibition of soybean lipoxygenase by sulfasalazine and 5-aminosalicylic acid: a possible mode of action in ulcerative colitis. Biochem Pharmacol. 1983 Jan 1;32(1):170-2. [PubMed:6131674]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Agonist
General Function
Zinc ion binding
Specific Function
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE...
Gene Name
PPARG
Uniprot ID
P37231
Uniprot Name
Peroxisome proliferator-activated receptor gamma
Molecular Weight
57619.58 Da
References
  1. Rousseaux C, Lefebvre B, Dubuquoy L, Lefebvre P, Romano O, Auwerx J, Metzger D, Wahli W, Desvergne B, Naccari GC, Chavatte P, Farce A, Bulois P, Cortot A, Colombel JF, Desreumaux P: Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma. J Exp Med. 2005 Apr 18;201(8):1205-15. Epub 2005 Apr 11. [PubMed:15824083]
  2. Schwab M, Reynders V, Loitsch S, Shastri YM, Steinhilber D, Schroder O, Stein J: PPARgamma is involved in mesalazine-mediated induction of apoptosis and inhibition of cell growth in colon cancer cells. Carcinogenesis. 2008 Jul;29(7):1407-14. doi: 10.1093/carcin/bgn118. Epub 2008 Jun 9. [PubMed:18544567]
  3. Linard C, Gremy O, Benderitter M: Reduction of peroxisome proliferation-activated receptor gamma expression by gamma-irradiation as a mechanism contributing to inflammatory response in rat colon: modulation by the 5-aminosalicylic acid agonist. J Pharmacol Exp Ther. 2008 Mar;324(3):911-20. Epub 2007 Dec 12. [PubMed:18077625]
  4. Desreumaux P, Ghosh S: Review article: mode of action and delivery of 5-aminosalicylic acid - new evidence. Aliment Pharmacol Ther. 2006 Sep;24 Suppl 1:2-9. [PubMed:16939423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Scaffold protein binding
Specific Function
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or oth...
Gene Name
CHUK
Uniprot ID
O15111
Uniprot Name
Inhibitor of nuclear factor kappa-B kinase subunit alpha
Molecular Weight
84638.88 Da
References
  1. Bantel H, Berg C, Vieth M, Stolte M, Kruis W, Schulze-Osthoff K: Mesalazine inhibits activation of transcription factor NF-kappaB in inflamed mucosa of patients with ulcerative colitis. Am J Gastroenterol. 2000 Dec;95(12):3452-7. [PubMed:11151876]
  2. Allgayer H: Review article: mechanisms of action of mesalazine in preventing colorectal carcinoma in inflammatory bowel disease. Aliment Pharmacol Ther. 2003 Sep;18 Suppl 2:10-4. [PubMed:12950415]
  3. Weber CK, Liptay S, Wirth T, Adler G, Schmid RM: Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta. Gastroenterology. 2000 Nov;119(5):1209-18. [PubMed:11054378]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Scaffold protein binding
Specific Function
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or oth...
Gene Name
IKBKB
Uniprot ID
O14920
Uniprot Name
Inhibitor of nuclear factor kappa-B kinase subunit beta
Molecular Weight
86563.245 Da
References
  1. Bantel H, Berg C, Vieth M, Stolte M, Kruis W, Schulze-Osthoff K: Mesalazine inhibits activation of transcription factor NF-kappaB in inflamed mucosa of patients with ulcerative colitis. Am J Gastroenterol. 2000 Dec;95(12):3452-7. [PubMed:11151876]
  2. Allgayer H: Review article: mechanisms of action of mesalazine in preventing colorectal carcinoma in inflammatory bowel disease. Aliment Pharmacol Ther. 2003 Sep;18 Suppl 2:10-4. [PubMed:12950415]
  3. Weber CK, Liptay S, Wirth T, Adler G, Schmid RM: Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta. Gastroenterology. 2000 Nov;119(5):1209-18. [PubMed:11054378]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Peroxidase activity
Specific Function
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production o...
Gene Name
MPO
Uniprot ID
P05164
Uniprot Name
Myeloperoxidase
Molecular Weight
83867.71 Da
References
  1. Nandi J, Saud B, Zinkievich JM, Palma DT, Levine RA: 5-aminosalicylic acid improves indomethacin-induced enteropathy by inhibiting iNOS transcription in rats. Dig Dis Sci. 2008 Jan;53(1):123-32. Epub 2007 May 15. [PubMed:17503181]
Kind
Protein
Organism
Mycobacterium tuberculosis
Pharmacological action
Unknown
General Function
Catalyzes the transfer of the acetyl group from acetyl coenzyme A to the free amino group of arylamines and hydrazines (PubMed:18795795). Is able to utilize not only acetyl-CoA, but also n-propionyl-CoA and acetoacetyl-CoA as acyl donors, although at a lower rate (PubMed:19014350). As acetyl-CoA and propionyl-CoA are products of cholesterol catabolism and the nat gene is likely present in the same operon than genes involved in cholesterol degradation, this enzyme could have a role in the utilization and regulation of these CoA species (PubMed:19014350).
Specific Function
Arylamine n-acetyltransferase activity
Gene Name
nat
Uniprot ID
P9WJI5
Uniprot Name
Arylamine N-acetyltransferase
Molecular Weight
31028.88 Da
References
  1. Tucker MA, Smith TJ: Acetylation of 5-aminosalicylate by hamster colon arylamine N-acetyltransferase. J Appl Toxicol. 1990 Feb;10(1):73-4. [PubMed:2335716]

Drug created on June 13, 2005 07:24 / Updated on June 19, 2018 10:51