Dopamine Agonists

Drugs that bind to and activate dopamine receptors.
DrugDrug NameDrug Description
DB00268RopiniroleA non-ergoline dopamine agonist used to treat the symptoms of Parkinson's disease and Restless Legs Syndrome.
DB00413PramipexoleA non-ergot dopamine agonist used to treat the signs and symptoms of idiopathic Parkinson's disease and Restless Legs Syndrome (RLS).
DB00714ApomorphineA morphine derivative D2 dopamine agonist used to treat hypomobile "off" episodes of advanced Parkinson's disease.
DB01186PergolideA long-acting dopamine agonist that is uncommonly used for the management of Parkinson's disease, due to the risk for cardiac valvulopathy.
DB01200BromocriptineA dopamine D2 receptor agonist used for the treatment of galactorrhea due to hyperprolactinemia and other prolactin-related conditions, as well as in early Parkinsonian Syndrome.
DB05271RotigotineA non-selective dopamine agonist used for the treatment of Parkinson's Disease and Restless Leg Syndrome.
DB12478PiribedilPiribedil has been investigated in Parkinson's Disease.
DB13385DihydroergocryptineNot Annotated
DB00800FenoldopamA dopamine D1 receptor agonist used for the short term management of hypertension.
DB00248CabergolineA dopamine receptor agonist used for the treatment of hyperprolactinemic conditions due to various causes.
DB00320DihydroergotamineAn ergot alkaloid used in the acute treatment of migraine headache and cluster headache.
DB01049Ergoloid mesylateA nootropic with an unknown mechanism of action indicated in individuals over sixty who manifest signs and symptoms of an idiopathic decline in mental capacity.
DB11273DihydroergocornineA nootropic with an unknown mechanism of action indicated in individuals over sixty who manifest signs and symptoms of an idiopathic decline in mental capacity.
DB12313DopexamineDopexamine has been used in trials studying the diagnostic and treatment of Free Flap, Oral Cancer, Hypotension, Septic Shock, and Head and Neck Cancer.
DB12890DihydrexidineDihydrexidine has been used in trials studying the treatment of SPD, Cocaine-Related Disorders, and Schizotypal Personality Disorder.
DB13316IbopamineNot Annotated
DB13520MetergolineMetergoline is an ergot-derived psychoactive drug that acts as a ligand for serotonin and dopamine receptors. Metergoline is an antagonist at various 5-HT receptor subtypes at a relatively low concentration...
DB00589LisurideFor the management of Parkinson's Disease
DB09097QuinagolideA dopamine D2 receptor agonist used for the treatment of hyperprolactinemia.
DB09128BrexpiprazoleA serotonin–dopamine activity modulator used in the treatment of major depressive disorder as an adjunct and schizophrenia.
DB01238AripiprazoleAn atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome.
DB15130DexpramipexoleDexpramipexole is under investigation in clinical trial NCT01511029 (Study to Evaluate the QTC Interval in Healthy Volunteers Dosed With Dexpramipexole (QTC = Electrocardiogram (ECG) Interval Measured From the Onset of...
DB06077LumateperoneA novel 2nd generation antipsychotic used to manage both positive and negative symptoms in patients with schizophrenia.
DrugDrug NameTargetType
DB00268RopiniroleDopamine D2 receptortarget
DB00268RopiniroleDopamine D3 receptortarget
DB00268RopiniroleDopamine D4 receptortarget
DB00268RopiniroleCytochrome P450 1A2enzyme
DB00268RopiniroleAlpha adrenergic receptortarget
DB00413PramipexoleDopamine D3 receptortarget
DB00413PramipexoleDopamine D4 receptortarget
DB00413PramipexoleDopamine D2 receptortarget
DB00413Pramipexole5-hydroxytryptamine receptor 1Atarget
DB00413PramipexoleAlpha-2A adrenergic receptortarget
DB00413PramipexoleSolute carrier family 22 member 2transporter
DB00413PramipexoleSolute carrier family 22 member 1transporter
DB00413PramipexoleSolute carrier family 22 member 3transporter
DB00714ApomorphineDopamine D2 receptortarget
DB00714ApomorphineDopamine D1 receptortarget
DB00714ApomorphineDopamine D4 receptortarget
DB00714ApomorphineDopamine D3 receptortarget
DB00714ApomorphineDopamine D5 receptortarget
DB00714ApomorphineNeuron-specific vesicular protein calcyontarget
DB00714ApomorphineAlpha-2C adrenergic receptortarget
DB00714ApomorphineAlpha-2B adrenergic receptortarget
DB00714Apomorphine5-hydroxytryptamine receptor 2Ctarget
DB00714Apomorphine5-hydroxytryptamine receptor 1Atarget
DB00714Apomorphine5-hydroxytryptamine receptor 2Atarget
DB00714Apomorphine5-hydroxytryptamine receptor 2Btarget
DB00714ApomorphineAlpha-2A adrenergic receptortarget
DB00714Apomorphine5-hydroxytryptamine receptor 1Dtarget
DB00714Apomorphine5-hydroxytryptamine receptor 1Btarget
DB01186PergolideDopamine D2 receptortarget
DB01186PergolideDopamine D1 receptortarget
DB01186PergolideDopamine D3 receptortarget
DB01186Pergolide5-hydroxytryptamine receptor 1Atarget
DB01186PergolideAlpha-1A adrenergic receptortarget
DB01186PergolideAlpha-2A adrenergic receptortarget
DB01186PergolideAlpha-2B adrenergic receptortarget
DB01186PergolideAlpha-2C adrenergic receptortarget
DB01186PergolideAlpha-1B adrenergic receptortarget
DB01186PergolideAlpha-1D adrenergic receptortarget
DB01186PergolideDopamine D4 receptortarget
DB01186PergolideDopamine D5 receptortarget
DB01186Pergolide5-hydroxytryptamine receptor 1Btarget
DB01186Pergolide5-hydroxytryptamine receptor 1Dtarget
DB01186Pergolide5-hydroxytryptamine receptor 2Atarget
DB01186Pergolide5-hydroxytryptamine receptor 2Btarget
DB01186Pergolide5-hydroxytryptamine receptor 2Ctarget
DB01186PergolideCytochrome P450 2D6enzyme
DB01186PergolideCytochrome P450 3A4enzyme
DB01200BromocriptineDopamine D2 receptortarget
DB01200BromocriptineCytochrome P450 3A4enzyme
DB01200Bromocriptine5-hydroxytryptamine receptor 1Dtarget
DB01200BromocriptineAlpha-2A adrenergic receptortarget
DB01200BromocriptineDopamine D3 receptortarget
DB01200Bromocriptine5-hydroxytryptamine receptor 1Atarget
DB01200BromocriptineAlpha-2C adrenergic receptortarget
DB01200BromocriptineAlpha-2B adrenergic receptortarget
DB01200Bromocriptine5-hydroxytryptamine receptor 2Btarget
DB01200BromocriptineDopamine D4 receptortarget
DB01200Bromocriptine5-hydroxytryptamine receptor 2Atarget
DB01200Bromocriptine5-hydroxytryptamine receptor 1Btarget
DB01200Bromocriptine5-hydroxytryptamine receptor 2Ctarget
DB01200BromocriptineDopamine D5 receptortarget
DB01200BromocriptineDopamine D1 receptortarget
DB01200BromocriptineAlpha-1A adrenergic receptortarget
DB01200BromocriptineAlpha-1B adrenergic receptortarget
DB01200BromocriptineAlpha-1D adrenergic receptortarget
DB01200Bromocriptine5-hydroxytryptamine receptor 7target
DB01200BromocriptineP-glycoprotein 1transporter
DB05271RotigotineDopamine D3 receptortarget
DB05271RotigotineDopamine D5 receptortarget
DB05271RotigotineDopamine D4 receptortarget
DB05271RotigotineDopamine D2 receptortarget
DB05271Rotigotine5-hydroxytryptamine receptor 1Atarget
DB05271RotigotineDopamine D1 receptortarget
DB05271RotigotineCytochrome P450 2D6enzyme
DB05271RotigotineCytochrome P450 3A4enzyme
DB05271RotigotineAlpha-2B adrenergic receptortarget
DB12478PiribedilDopamine D2 receptortarget
DB12478PiribedilDopamine D3 receptortarget
DB13385DihydroergocryptineCytochrome P450 3A4enzyme
DB00800FenoldopamDopamine D5 receptortarget
DB00800FenoldopamDopamine D1 receptortarget
DB00800FenoldopamAlpha-2B adrenergic receptortarget
DB00800FenoldopamAlpha-2C adrenergic receptortarget
DB00800FenoldopamAlpha-2A adrenergic receptortarget
DB00800FenoldopamAlpha-1B adrenergic receptortarget
DB00800FenoldopamAlpha-1D adrenergic receptortarget
DB00800FenoldopamAlpha-1A adrenergic receptortarget
DB00248CabergolineDopamine D2 receptortarget
DB00248Cabergoline5-hydroxytryptamine receptor 2Btarget
DB00248CabergolineDopamine D3 receptortarget
DB00248Cabergoline5-hydroxytryptamine receptor 2Atarget
DB00248CabergolineAlpha-2B adrenergic receptortarget
DB00248Cabergoline5-hydroxytryptamine receptor 1Dtarget
DB00248CabergolineDopamine D4 receptortarget
DB00248CabergolineAlpha-2A adrenergic receptortarget
DB00248Cabergoline5-hydroxytryptamine receptor 1Atarget
DB00248CabergolineAlpha-2C adrenergic receptortarget
DB00248CabergolineDopamine D5 receptortarget
DB00248CabergolineDopamine D1 receptortarget
DB00248Cabergoline5-hydroxytryptamine receptor 1Btarget
DB00248Cabergoline5-hydroxytryptamine receptor 2Ctarget
DB00248CabergolineCytochrome P450 3A4enzyme
DB00248Cabergoline5-hydroxytryptamine receptor 7target
DB00248CabergolineAlpha-1A adrenergic receptortarget
DB00248CabergolineAlpha-1B adrenergic receptortarget
DB00248CabergolineAlpha-1D adrenergic receptortarget
DB00248CabergolineBeta-1 adrenergic receptortarget
DB00248CabergolineBeta-2 adrenergic receptortarget
DB00248CabergolineD(1) dopamine receptortarget
DB00248CabergolineP-glycoprotein 1transporter
DB00320Dihydroergotamine5-hydroxytryptamine receptor 1Dtarget
DB00320Dihydroergotamine5-hydroxytryptamine receptor 1Btarget
DB00320DihydroergotamineCytochrome P450 3A4enzyme
DB00320DihydroergotamineAlpha-2A adrenergic receptortarget
DB00320Dihydroergotamine5-hydroxytryptamine receptor 2Btarget
DB00320DihydroergotamineP-glycoprotein 1transporter
DB01049Ergoloid mesylateDopamine receptortarget
DB01049Ergoloid mesylateAlpha adrenergic receptortarget
DB01049Ergoloid mesylateBeta adrenergic receptortarget
DB01049Ergoloid mesylateSerotonin Receptorstarget
DB01049Ergoloid mesylateCytochrome P450 3A4enzyme
DB11273DihydroergocornineSerotonin Receptorstarget
DB11273DihydroergocornineBeta adrenergic receptortarget
DB11273DihydroergocornineAlpha adrenergic receptortarget
DB11273DihydroergocornineCytochrome P450 3A4enzyme
DB12890DihydrexidineDopamine D1 receptortarget
DB13520MetergolineSodium channel protein type 2 subunit alphatarget
DB00589LisurideDopamine D1 receptortarget
DB00589Lisuride5-hydroxytryptamine receptor 1Atarget
DB00589LisurideDopamine D2 receptortarget
DB00589LisurideAlpha-2A adrenergic receptortarget
DB00589LisurideAlpha-2B adrenergic receptortarget
DB00589LisurideAlpha-2C adrenergic receptortarget
DB00589LisurideDopamine D3 receptortarget
DB00589Lisuride5-hydroxytryptamine receptor 1Dtarget
DB00589Lisuride5-hydroxytryptamine receptor 2Btarget
DB00589Lisuride5-hydroxytryptamine receptor 2Atarget
DB00589LisurideDopamine D4 receptortarget
DB00589Lisuride5-hydroxytryptamine receptor 2Ctarget
DB00589LisurideDopamine D5 receptortarget
DB00589Lisuride5-hydroxytryptamine receptor 1Btarget
DB00589LisurideCytochrome P450 3A4enzyme
DB00589Lisuride5-hydroxytryptamine receptor 7target
DB09097QuinagolideDopamine D2 receptortarget
DB09097QuinagolideD(1) dopamine receptortarget
DB09128BrexpiprazoleCytochrome P450 2D6enzyme
DB09128BrexpiprazoleCytochrome P450 3A4enzyme
DB09128Brexpiprazole5-hydroxytryptamine receptor 1Atarget
DB09128BrexpiprazoleDopamine D2 receptortarget
DB09128Brexpiprazole5-hydroxytryptamine receptor 2Atarget
DB09128BrexpiprazoleAlpha-2C adrenergic receptortarget
DB09128BrexpiprazoleAlpha-1B adrenergic receptortarget
DB01238AripiprazoleDopamine D2 receptortarget
DB01238Aripiprazole5-hydroxytryptamine receptor 1Atarget
DB01238Aripiprazole5-hydroxytryptamine receptor 2Atarget
DB01238AripiprazoleCytochrome P450 3A4enzyme
DB01238AripiprazoleCytochrome P450 2D6enzyme
DB01238Aripiprazole5-hydroxytryptamine receptor 1Btarget
DB01238Aripiprazole5-hydroxytryptamine receptor 1Dtarget
DB01238Aripiprazole5-hydroxytryptamine receptor 1Etarget
DB01238AripiprazoleDopamine D1 receptortarget
DB01238AripiprazoleDopamine D5 receptortarget
DB01238AripiprazoleDopamine D3 receptortarget
DB01238AripiprazoleDopamine D4 receptortarget
DB01238Aripiprazole5-hydroxytryptamine receptor 2Ctarget
DB01238Aripiprazole5-hydroxytryptamine receptor 3Atarget
DB01238Aripiprazole5-hydroxytryptamine receptor 6target
DB01238Aripiprazole5-hydroxytryptamine receptor 7target
DB01238AripiprazoleHistamine H1 receptortarget
DB01238AripiprazoleAlpha-1A adrenergic receptortarget
DB01238AripiprazoleAlpha-1B adrenergic receptortarget
DB01238AripiprazoleAlpha-2A adrenergic receptortarget
DB01238AripiprazoleAlpha-2B adrenergic receptortarget
DB01238AripiprazoleAlpha-2C adrenergic receptortarget
DB01238AripiprazoleCytochrome P450 3A5enzyme
DB01238AripiprazoleCytochrome P450 3A7enzyme
DB01238AripiprazoleSerum albumincarrier
DB01238Aripiprazole5-hydroxytryptamine receptor 2Btarget
DB01238Aripiprazole5-hydroxytryptamine receptor 5Atarget
DB01238AripiprazoleBeta-1 adrenergic receptortarget
DB01238AripiprazoleBeta-2 adrenergic receptortarget
DB01238AripiprazoleHistamine H2 receptortarget
DB01238AripiprazoleHistamine H3 receptortarget
DB01238AripiprazoleHistamine H4 receptortarget
DB01238AripiprazoleMuscarinic acetylcholine receptor M1target
DB01238AripiprazoleMuscarinic acetylcholine receptor M2target
DB01238AripiprazoleMuscarinic acetylcholine receptor M3target
DB01238AripiprazoleMuscarinic acetylcholine receptor M4target
DB01238AripiprazoleMuscarinic acetylcholine receptor M5target
DB01238AripiprazoleKappa-type opioid receptortarget
DB01238AripiprazoleMu-type opioid receptortarget
DB01238AripiprazoleDelta-type opioid receptortarget
DB01238AripiprazoleGlutamate (NMDA) receptortarget
DB01238AripiprazoleSodium-dependent dopamine transportertarget
DB01238AripiprazoleSodium-dependent serotonin transportertarget
DB06077Lumateperone5-hydroxytryptamine receptor 2Atarget
DB06077LumateperoneDopamine D2 receptortarget
DB06077LumateperoneDopamine D1 receptortarget
DB06077LumateperoneSodium-dependent serotonin transportertarget
DB06077LumateperoneGlutamate receptor ionotropic, NMDA 2Btarget
DB06077LumateperoneAldo-keto reductase familyenzyme
DB06077LumateperoneCytochrome P450 3A4enzyme
DB06077LumateperoneCytochrome P450 2C8enzyme
DB06077LumateperoneCytochrome P450 1A2enzyme
DB06077LumateperoneUDP-glucuronosyltransferase 1-1enzyme
DB06077LumateperoneUDP-glucuronosyltransferase 1-4enzyme
DB06077LumateperoneUDP-glucuronosyltransferase 2B15enzyme
DB06077LumateperoneAldo-keto reductase family 1 member C1enzyme
DB06077LumateperoneAldo-keto reductase family 1 member B10enzyme
DB06077LumateperoneAldo-keto reductase family 1 member C4enzyme