Dopamine Agonists

Drugs that bind to and activate dopamine receptors.
DrugDrug NameDrug Indication
DB00268RopiniroleFor the treatment of the signs and symptoms of Parkinson's disease and for the treatment of primary moderate-severe restless legs syndrome [FDA label].
DB00413PramipexoleThis drug is indicated for the symptomatic treatment of Parkinson’s disease [FDA label]. This drug can be administered as monotherapy or in conjunction with levodopa. It is also indicated for symptomatic treatment of moderate to severe primary Restless Legs Syndrome (RLS) [FDA label].
DB00714ApomorphineFor the acute, intermittent treatment of hypomobility, off episodes (end-of-dose wearing off and unpredictable on/off episodes) associated with advanced Parkinson's disease.
DB01186PergolideIndicated as adjunctive treatment to levodopa/carbidopa in the management of the signs and symptoms of Parkinson's disease. It was withdrawn from the US and Canadian markets in 2007 due to an increased risk of cardiac valvulopathy.
DB01200BromocriptineFor the treatment of galactorrhea due to hyperprolactinemia, prolactin-dependent menstrual disorders and infertility, prolactin-secreting adenomas, prolactin-dependent male hypogonadism, as adjunct therapy to surgery or radiotherapy for acromegaly or as monotherapy is special cases, as monotherapy in early Parksinsonian Syndrome or as an adjunct with levodopa in advanced cases with motor complications. Bromocriptine has also been used off-label to treat restless legs syndrome and neuroleptic malignant syndrome.
DB05271RotigotineFor use/treatment in neurologic disorders and parkinson's disease as well as moderate-to-severe primary Restless Legs Syndrome.
DB12478PiribedilNot Available
DB13385DihydroergocryptineNot Available
DB00800FenoldopamFor the in-hospital, short-term (up to 48 hours) management of severe hypertension when rapid, but quickly reversible, emergency reduction of blood pressure is clinically indicated, including malignant hypertension with deteriorating end-organ function.
DB00248CabergolineFor the treatment of hyperprolactinemic disorders, either idiopathic or due to prolactinoma (prolactin-secreting adenomas). May also be used to manage symptoms of Parkinsonian Syndrome as monotherapy during initial symptomatic management or as an adjunct to levodopa therapy during advanced stages of disease.
DB00320DihydroergotamineFor the acute treatment of migraine headaches with or without aura and the acute treatment of cluster headache episodes.
DB01049Ergoloid mesylateIt was labeled by the FDA for the treatment of symptoms of an idiopathic decline in the mental capacity not related to a potentially reversible condition[A32913] as well as for age-related cognitive impairment.[A32926] The prescription of this drug is conditioned to the corroboration that the patient is not suffering from a potentially reversible and treatable condition especially delirium and dementiform illness secondary to systemic disease, primary neurological disease or primary mood disturbance.[L2637] To know more about the individual components of the ergoloid mixture, please visit [DB13345] and [DB11274]
DB11273DihydroergocornineTo know more about the approved indications please visit [DB01049]
DB12313DopexamineNot Available
DB12890DihydrexidineNot Available
DB13316IbopamineNot Available
DB13520MetergolineNot Available
DB00589LisurideFor the management of Parkinson's Disease
DB09097QuinagolideIndicated for the treatment of hyperprolactinemia (idiopathic or originating from a prolactin-secreting pituitary microadenoma or macroadenoma).
DB09128BrexpiprazoleAs an adjunctive treatment of major depressive disorder (MDD) and for treatment of schizophrenia.
DB15130DexpramipexoleNot Available
DrugDrug NameTargetType
DB00268RopiniroleD(2) dopamine receptortarget
DB00268RopiniroleD(3) dopamine receptortarget
DB00268RopiniroleD(4) dopamine receptortarget
DB00268RopiniroleCytochrome P450 1A2enzyme
DB00268RopiniroleAlpha adrenergic receptortarget
DB00413PramipexoleD(3) dopamine receptortarget
DB00413PramipexoleD(4) dopamine receptortarget
DB00413PramipexoleD(2) dopamine receptortarget
DB00413Pramipexole5-hydroxytryptamine receptor 1Atarget
DB00413PramipexoleAlpha-2A adrenergic receptortarget
DB00413PramipexoleSolute carrier family 22 member 2transporter
DB00413PramipexoleSolute carrier family 22 member 1transporter
DB00413PramipexoleSolute carrier family 22 member 3transporter
DB00714ApomorphineD(2) dopamine receptortarget
DB00714ApomorphineD(1A) dopamine receptortarget
DB00714ApomorphineD(4) dopamine receptortarget
DB00714ApomorphineD(3) dopamine receptortarget
DB00714ApomorphineD(1B) dopamine receptortarget
DB00714ApomorphineNeuron-specific vesicular protein calcyontarget
DB00714ApomorphineAlpha-2C adrenergic receptortarget
DB00714ApomorphineAlpha-2B adrenergic receptortarget
DB00714Apomorphine5-hydroxytryptamine receptor 2Ctarget
DB00714Apomorphine5-hydroxytryptamine receptor 1Atarget
DB00714Apomorphine5-hydroxytryptamine receptor 2Atarget
DB00714Apomorphine5-hydroxytryptamine receptor 2Btarget
DB00714ApomorphineAlpha-2A adrenergic receptortarget
DB00714Apomorphine5-hydroxytryptamine receptor 1Dtarget
DB00714Apomorphine5-hydroxytryptamine receptor 1Btarget
DB01186PergolideD(2) dopamine receptortarget
DB01186PergolideD(1A) dopamine receptortarget
DB01186PergolideD(3) dopamine receptortarget
DB01186Pergolide5-hydroxytryptamine receptor 1Atarget
DB01186PergolideAlpha-1A adrenergic receptortarget
DB01186PergolideAlpha-2A adrenergic receptortarget
DB01186PergolideAlpha-2B adrenergic receptortarget
DB01186PergolideAlpha-2C adrenergic receptortarget
DB01186PergolideAlpha-1B adrenergic receptortarget
DB01186PergolideAlpha-1D adrenergic receptortarget
DB01186PergolideD(4) dopamine receptortarget
DB01186PergolideD(1B) dopamine receptortarget
DB01186Pergolide5-hydroxytryptamine receptor 1Btarget
DB01186Pergolide5-hydroxytryptamine receptor 1Dtarget
DB01186Pergolide5-hydroxytryptamine receptor 2Atarget
DB01186Pergolide5-hydroxytryptamine receptor 2Btarget
DB01186Pergolide5-hydroxytryptamine receptor 2Ctarget
DB01186PergolideCytochrome P450 2D6enzyme
DB01186PergolideCytochrome P450 3A4enzyme
DB01200BromocriptineD(2) dopamine receptortarget
DB01200BromocriptineCytochrome P450 3A4enzyme
DB01200Bromocriptine5-hydroxytryptamine receptor 1Dtarget
DB01200BromocriptineAlpha-2A adrenergic receptortarget
DB01200BromocriptineD(3) dopamine receptortarget
DB01200Bromocriptine5-hydroxytryptamine receptor 1Atarget
DB01200BromocriptineAlpha-2C adrenergic receptortarget
DB01200BromocriptineAlpha-2B adrenergic receptortarget
DB01200Bromocriptine5-hydroxytryptamine receptor 2Btarget
DB01200BromocriptineD(4) dopamine receptortarget
DB01200Bromocriptine5-hydroxytryptamine receptor 2Atarget
DB01200Bromocriptine5-hydroxytryptamine receptor 1Btarget
DB01200Bromocriptine5-hydroxytryptamine receptor 2Ctarget
DB01200BromocriptineD(1B) dopamine receptortarget
DB01200BromocriptineD(1A) dopamine receptortarget
DB01200BromocriptineAlpha-1A adrenergic receptortarget
DB01200BromocriptineAlpha-1B adrenergic receptortarget
DB01200BromocriptineAlpha-1D adrenergic receptortarget
DB01200Bromocriptine5-hydroxytryptamine receptor 7target
DB01200BromocriptineMultidrug resistance protein 1transporter
DB05271RotigotineD(3) dopamine receptortarget
DB05271RotigotineD(1B) dopamine receptortarget
DB05271RotigotineD(4) dopamine receptortarget
DB05271RotigotineD(2) dopamine receptortarget
DB05271Rotigotine5-hydroxytryptamine receptor 1Atarget
DB05271RotigotineD(1A) dopamine receptortarget
DB05271RotigotineCytochrome P450 2D6enzyme
DB05271RotigotineCytochrome P450 3A4enzyme
DB05271RotigotineAlpha-2B adrenergic receptortarget
DB12478PiribedilD(2) dopamine receptortarget
DB12478PiribedilD(3) dopamine receptortarget
DB13385DihydroergocryptineCytochrome P450 3A4enzyme
DB00800FenoldopamD(1B) dopamine receptortarget
DB00800FenoldopamD(1A) dopamine receptortarget
DB00800FenoldopamAlpha-2B adrenergic receptortarget
DB00800FenoldopamAlpha-2C adrenergic receptortarget
DB00800FenoldopamAlpha-2A adrenergic receptortarget
DB00800FenoldopamAlpha-1B adrenergic receptortarget
DB00800FenoldopamAlpha-1D adrenergic receptortarget
DB00800FenoldopamAlpha-1A adrenergic receptortarget
DB00248CabergolineD(2) dopamine receptortarget
DB00248Cabergoline5-hydroxytryptamine receptor 2Btarget
DB00248CabergolineD(3) dopamine receptortarget
DB00248Cabergoline5-hydroxytryptamine receptor 2Atarget
DB00248CabergolineAlpha-2B adrenergic receptortarget
DB00248Cabergoline5-hydroxytryptamine receptor 1Dtarget
DB00248CabergolineD(4) dopamine receptortarget
DB00248CabergolineAlpha-2A adrenergic receptortarget
DB00248Cabergoline5-hydroxytryptamine receptor 1Atarget
DB00248CabergolineAlpha-2C adrenergic receptortarget
DB00248CabergolineD(1B) dopamine receptortarget
DB00248CabergolineD(1A) dopamine receptortarget
DB00248Cabergoline5-hydroxytryptamine receptor 1Btarget
DB00248Cabergoline5-hydroxytryptamine receptor 2Ctarget
DB00248CabergolineCytochrome P450 3A4enzyme
DB00248Cabergoline5-hydroxytryptamine receptor 7target
DB00248CabergolineAlpha-1A adrenergic receptortarget
DB00248CabergolineAlpha-1B adrenergic receptortarget
DB00248CabergolineAlpha-1D adrenergic receptortarget
DB00248CabergolineBeta-1 adrenergic receptortarget
DB00248CabergolineBeta-2 adrenergic receptortarget
DB00248CabergolineD(1) dopamine receptortarget
DB00248CabergolineD(2S) dopamine receptortarget
DB00248CabergolineD(2L) dopamine receptortarget
DB00248CabergolineMultidrug resistance protein 1transporter
DB00320Dihydroergotamine5-hydroxytryptamine receptor 1Dtarget
DB00320Dihydroergotamine5-hydroxytryptamine receptor 1Btarget
DB00320DihydroergotamineCytochrome P450 3A4enzyme
DB00320DihydroergotamineAlpha-2A adrenergic receptortarget
DB00320Dihydroergotamine5-hydroxytryptamine receptor 2Btarget
DB00320DihydroergotamineMultidrug resistance protein 1transporter
DB01049Ergoloid mesylateDopamine receptortarget
DB01049Ergoloid mesylateAlpha adrenergic receptortarget
DB01049Ergoloid mesylateBeta adrenergic receptortarget
DB01049Ergoloid mesylateSerotonin Receptorstarget
DB01049Ergoloid mesylateCytochrome P450 3A4enzyme
DB11273DihydroergocornineSerotonin Receptorstarget
DB11273DihydroergocornineBeta adrenergic receptortarget
DB11273DihydroergocornineAlpha adrenergic receptortarget
DB11273DihydroergocornineCytochrome P450 3A4enzyme
DB12890DihydrexidineD(1A) dopamine receptortarget
DB13520MetergolineSodium channel protein type 2 subunit alphatarget
DB00589LisurideD(1A) dopamine receptortarget
DB00589Lisuride5-hydroxytryptamine receptor 1Atarget
DB00589LisurideD(2) dopamine receptortarget
DB00589LisurideAlpha-2A adrenergic receptortarget
DB00589LisurideAlpha-2B adrenergic receptortarget
DB00589LisurideAlpha-2C adrenergic receptortarget
DB00589LisurideD(3) dopamine receptortarget
DB00589Lisuride5-hydroxytryptamine receptor 1Dtarget
DB00589Lisuride5-hydroxytryptamine receptor 2Btarget
DB00589Lisuride5-hydroxytryptamine receptor 2Atarget
DB00589LisurideD(4) dopamine receptortarget
DB00589Lisuride5-hydroxytryptamine receptor 2Ctarget
DB00589LisurideD(1B) dopamine receptortarget
DB00589Lisuride5-hydroxytryptamine receptor 1Btarget
DB00589LisurideCytochrome P450 2D6enzyme
DB00589LisurideCytochrome P450 3A4enzyme
DB00589Lisuride5-hydroxytryptamine receptor 7target
DB09097QuinagolideD(2) dopamine receptortarget
DB09097QuinagolideD(1) dopamine receptortarget
DB09128BrexpiprazoleCytochrome P450 2D6enzyme
DB09128BrexpiprazoleCytochrome P450 3A4enzyme
DB09128Brexpiprazole5-hydroxytryptamine receptor 1Atarget
DB09128BrexpiprazoleD(2) dopamine receptortarget
DB09128Brexpiprazole5-hydroxytryptamine receptor 2Atarget
DB09128BrexpiprazoleAlpha-2C adrenergic receptortarget
DB09128BrexpiprazoleAlpha-1B adrenergic receptortarget