Penicillins

Name
Penicillins
Accession Number
DBCAT000702  (DBCAT000739, DBCAT003326)
Description

A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)

ATC Classification
Drugs
DrugDrug Description
CloxacillinAn antibiotic agent used for the treatment of beta-hemolytic streptococcal and pneumococcal infections as well as staphylococcal infections.
PivmecillinamA prodrug of the beta lactam antibiotic mecillinam, indicated for the treatment of uncomplicated urinary tract infections (UTIs).
FlucloxacillinA narrow spectrum penicillin antibiotic that exerts specific activity against Gram positive organisms in skin and soft tissue infections, except those caused by methicillin resistant staphylococcus aureus (MRSA).
AmpicillinA penicillin derivative used for the treatment of a variety of infections caused by gram-positive and gram-negative bacteria as well as some anaerobes.
PhenoxymethylpenicillinA penicillin antibiotic used to prevent and treat mild to moderately severe infections in the respiratory tract, skin, and soft tissues.
DicloxacillinA penicillin used to treat penicillinase-producing bacterial infections that are susceptible to the drug.
CarbenicillinFor the treatment of acute and chronic infections of the upper and lower urinary tract and in asymptomatic bacteriuria due to susceptible strains of bacteria.
NafcillinA penicillin derivative antibiotic used to treat susceptible staphylococcal infections.
OxacillinA penicillin antibiotic used to treat a number of susceptible bacterial infections.
Benzylpenicilloyl polylysineA penicillin derivative used to determine penicillin allergies.
CyclacillinFor the treatment of bacterial infections caused by susceptible organisms.
BenzylpenicillinA penicillin used for the treatment of infections caused by gram-positive cocci, in particular streptococcal infections. This form of penicillin is typically used in intravenous or long-acting injectable formulations due to poor oral absorption.
AmoxicillinA penicillin derivative used for the treatment of infections caused by gram-positive bacteria, in particular streptococcal bacteria causing upper respiratory tract infections.
AmdinocillinUsed in the treatment of urinary tract infections caused by some strains of E. coli and klebsiella and enterobacter species. Used mainly against Gram negative organisms.
BacampicillinFor infections at the following sites: upper and lower respiratory tract; skin and soft tissue; urinary tract and acute uncomplicated gonococcal urethritis, when due to sensitive strains of the following...
MeticillinUsed to treat infections caused by susceptible Gram-positive bacteria, particularly beta-lactamase-producing organisms such as Staphylococcus aureus that would otherwise be resistant to most penicillins.
TicarcillinA beta lactam antibiotic used to treat a variety of infections in the body.
AzidocillinFor treatment of infection (Respiratory, GI, UTI and meningitis) due to E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, nonpenicillinase-producing N. gononhoeae, H. influenzae, staphylococci, streptococci including...
CarindacillinA penicillin antibiotic used to treat a variety of infections, but is no longer marketed in the USA.
Procaine benzylpenicillinA local anesthetic and antibiotic combination for intramuscular injection to treat a variety of bacterial infections while reducing pain from a deep intramuscular injection.
SultamicillinSultamicillin has been used in trials studying the prevention and treatment of Ventilator Associated Pneumonia and Chronic Obstructive Pulmonary Disease (COPD).
EpicillinNot Annotated
CarfecillinNot Annotated
PropicillinNot Annotated
SulbenicillinNot Annotated
PenamecillinNot Annotated
MetampicillinMetampicillin is a penicillin antibiotic prepared by the reaction of ampicillin with formaldehyde. It is hydrolysed in aqueous solution to form ampicillin. Hydrolysis is rapid under acid conditions like the...
TemocillinTemocillin has been investigated in Infection, Liver Dysfunction, and Urinary Tract Infection.
PiperacillinA penicillin antibiotic combined with tazobactam to treat piperacillin-resistant, piperacillin/tazobactam­ susceptible, β-lactamase generating strains of several bacteria.
MezlocillinUsed to treat serious gram–negative infections of the lungs, urinary tract, and skin.
AzlocillinFor the treatment of infections caused by Pseudomonas aeruginosa, Escherichia coli, and Haemophilus influenzae.
PivampicillinAn ampicillin prodrug used to treat a variety of infections.
TalampicillinNot Annotated
AspoxicillinNot Annotated
PheneticillinPheneticillin (or phenethicillin) is a penicillin antibiotic which is approved for use internationally.
HetacillinHetacillin is a beta-lactam antibiotic prodrug used to treat bacterial infections. In the body it gets converted to ampicillin.
ClometocillinNot Annotated
Drugs & Drug Targets
DrugTargetType
CloxacillinPenicillin-binding protein 1Atarget
CloxacillinBeta-lactamasetarget
CloxacillinSerum albumincarrier
CloxacillinSolute carrier family 15 member 1transporter
CloxacillinSolute carrier family 15 member 2transporter
CloxacillinSolute carrier family 22 member 6transporter
CloxacillinPenicillin-binding protein 2atarget
CloxacillinPenicillin-binding protein 2Btarget
CloxacillinPenicillin-binding protein 3target
CloxacillinD-alanyl-D-alanine carboxypeptidase DacAtarget
PivmecillinamPenicillin-binding protein 1Atarget
FlucloxacillinPenicillin-binding protein 1Atarget
FlucloxacillinCytochrome P450 3A4enzyme
FlucloxacillinBile salt export pumptransporter
AmpicillinSerum albumincarrier
AmpicillinSolute carrier family 22 member 5transporter
AmpicillinSolute carrier family 15 member 1transporter
AmpicillinSolute carrier family 15 member 2transporter
AmpicillinPenicillin-binding protein 2atarget
AmpicillinPenicillin-binding protein 1btarget
AmpicillinPenicillin-binding protein 3target
AmpicillinPenicillin-binding protein 1Atarget
AmpicillinPenicillin-binding protein 2Btarget
AmpicillinMonocarboxylate transporter 1transporter
AmpicillinSolute carrier family 15 member 1target
AmpicillinSolute carrier family 15 member 2target
AmpicillinAngiopoietin-1 receptortarget
PhenoxymethylpenicillinPenicillin-binding protein 1Atarget
PhenoxymethylpenicillinMecA PBP2' (penicillin binding protein 2')target
PhenoxymethylpenicillinD-alanyl-D-alanine carboxypeptidase DacBtarget
PhenoxymethylpenicillinPenicillin acylasetarget
PhenoxymethylpenicillinSolute carrier family 15 member 1target
DicloxacillinSolute carrier family 15 member 1transporter
DicloxacillinSolute carrier family 15 member 2transporter
DicloxacillinPenicillin-binding protein 3target
DicloxacillinPenicillin-binding protein 1btarget
DicloxacillinPenicillin-binding protein 2atarget
DicloxacillinPenicillin-binding protein 3target
DicloxacillinPenicillin-binding protein 1Atarget
DicloxacillinPenicillin-binding protein 2Btarget
DicloxacillinCytochrome P450 3A4enzyme
CarbenicillinSolute carrier family 22 member 6transporter
CarbenicillinPenicillin-binding proteintarget
CarbenicillinCytosolic phospholipase A2enzyme
NafcillinCytochrome P450 1A2enzyme
NafcillinCytochrome P450 3A4enzyme
NafcillinSolute carrier family 22 member 6transporter
NafcillinPenicillin-binding protein 1btarget
NafcillinPenicillin-binding protein 2Btarget
NafcillinPenicillin-binding protein 2atarget
NafcillinPenicillin-binding protein 3target
NafcillinPenicillin-binding protein 1Atarget
NafcillinSerum albumincarrier
OxacillinPenicillin-binding protein 1Atarget
OxacillinSolute carrier family 15 member 1transporter
OxacillinSolute carrier family 15 member 2transporter
OxacillinPenicillin-binding protein 3target
OxacillinPenicillin-binding protein 2atarget
OxacillinPenicillin-binding protein 1Atarget
OxacillinPenicillin-binding protein 2Btarget
OxacillinPenicillin-binding protein 1btarget
OxacillinSolute carrier family 15 member 1target
OxacillinPenicillin-binding protein 2target
OxacillinSolute carrier family 15 member 2target
Benzylpenicilloyl polylysineHigh affinity immunoglobulin epsilon receptor subunit gammatarget
Benzylpenicilloyl polylysineHigh affinity immunoglobulin epsilon receptor subunit alphatarget
CyclacillinSolute carrier family 22 member 5transporter
CyclacillinSolute carrier family 15 member 1transporter
CyclacillinSolute carrier family 15 member 2transporter
CyclacillinPenicillin-binding protein 1Atarget
CyclacillinPenicillin-binding protein 3target
CyclacillinPenicillin binding protein 2atarget
CyclacillinPenicillin-binding proteintarget
BenzylpenicillinSolute carrier family 22 member 5transporter
BenzylpenicillinSolute carrier family 15 member 1transporter
BenzylpenicillinSolute carrier family 15 member 2transporter
BenzylpenicillinSolute carrier family 22 member 6transporter
BenzylpenicillinSolute carrier family 22 member 8transporter
BenzylpenicillinSolute carrier family 22 member 4transporter
BenzylpenicillinSolute carrier family 22 member 11transporter
BenzylpenicillinSolute carrier organic anion transporter family member 2B1transporter
BenzylpenicillinSolute carrier organic anion transporter family member 4A1transporter
BenzylpenicillinSolute carrier organic anion transporter family member 3A1transporter
BenzylpenicillinSolute carrier organic anion transporter family member 1B1transporter
BenzylpenicillinPenicillin-binding protein 3target
BenzylpenicillinSolute carrier family 22 member 8target
BenzylpenicillinSolute carrier family 15 member 1target
BenzylpenicillinSolute carrier family 15 member 2target
BenzylpenicillinBeta-lactamase TEMenzyme
BenzylpenicillinSerum albumincarrier
AmoxicillinSolute carrier family 15 member 1transporter
AmoxicillinSolute carrier family 15 member 2transporter
AmoxicillinSolute carrier family 22 member 6transporter
AmoxicillinCytochrome P450 2C8enzyme
AmoxicillinSerum albumincarrier
AmoxicillinBeta-lactamase 2enzyme
AmoxicillinPenicillin binding proteintarget
AmdinocillinPenicillin-binding protein 2target
AmdinocillinPenicillin-binding protein 2atarget
AmdinocillinPenicillin-binding protein 3target
AmdinocillinPenicillin-binding protein 1Atarget
AmdinocillinPenicillin-binding protein 2Btarget
AmdinocillinPenicillin-binding protein 1btarget
BacampicillinPenicillin-binding proteintarget
MeticillinMecA PBP2' (penicillin binding protein 2')target
MeticillinPenicillin-binding protein 2atarget
MeticillinPenicillin-binding protein 1btarget
MeticillinPenicillin-binding protein 2Btarget
MeticillinPenicillin-binding protein 3target
MeticillinPenicillin-binding protein 1Atarget
TicarcillinPenicillin binding protein 2atarget
AzidocillinPenicillin-binding protein 2atarget
AzidocillinPenicillin-binding protein 1btarget
AzidocillinPenicillin-binding protein 3target
AzidocillinPenicillin-binding protein 1Atarget
AzidocillinPenicillin-binding protein 2Btarget
AzidocillinSolute carrier family 22 member 5transporter
AzidocillinSolute carrier family 15 member 1transporter
AzidocillinSolute carrier family 15 member 2transporter
CarindacillinPenicillin-binding proteintarget
PiperacillinSolute carrier family 22 member 6transporter
PiperacillinPenicillin-binding protein 3target
PiperacillinPenicillin-binding protein 2Btarget
PiperacillinPenicillin-binding protein 2atarget
PiperacillinPenicillin-binding protein 1btarget
PiperacillinSolute carrier family 22 member 8transporter
MezlocillinPenicillin-binding protein 1Atarget
MezlocillinPenicillin-binding protein 2target
MezlocillinPenicillin-binding protein 3target
AzlocillinPenicillin-binding protein 1Atarget
PivampicillinPenicillin-binding protein 1Atarget
HetacillinPenicillin-binding protein 2atarget
HetacillinPenicillin-binding protein 1btarget
HetacillinPenicillin-binding protein 3target
HetacillinPenicillin-binding protein 1Atarget
HetacillinPenicillin-binding protein 2Btarget