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Identification
NameNafcillin
Accession NumberDB00607  (APRD01130, DB08269)
TypeSmall Molecule
GroupsApproved
DescriptionA semi-synthetic antibiotic related to penicillin. [PubChem]
Structure
Thumb
Synonyms
(2-Ethoxy-1-naphthalenyl)penicillin
(2-Ethoxy-1-naphthyl)penicillin
(2S,5R,6R)-6-{[(2-ethoxynaphthalen-1-yl)carbonyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
6-(2-Ethoxy-1-naphthamido)penicillanic acid
Nafcilina
Nafcilline
Nafcillinum
Naphcillin
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
NafcillinInjection, solution1 g/50mLIntravenousBaxter Healthcare Corporation1989-10-31Not applicableUs
NafcillinInjection, solution2 g/100mLIntravenousBaxter Healthcare Corporation1989-10-31Not applicableUs
Unipen Injection Pws 500mg/vialPowder, for solution500 mgIntramuscular; IntravenousWyeth Ayerst Canada Inc.1994-12-311998-08-13Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
NafcillinInjection, powder, for solution1 g/1Intramuscular; IntravenousSandoz Inc1984-08-02Not applicableUs
NafcillinInjection, powder, for solution10 g/100mLIntravenousAuro Medics Pharma Llc2012-12-26Not applicableUs
NafcillinInjection1 g/1Intramuscular; IntravenousClaris Lifesciences, Inc.2012-02-01Not applicableUs
NafcillinInjection, powder, for solution10 g/100mLIntravenousSandoz Inc1984-08-02Not applicableUs
NafcillinInjection, powder, for solution10 g/100mLIntravenousWG Critical Care, LLC2011-04-27Not applicableUs
NafcillinInjection, powder, for solution2 g/1Intramuscular; IntravenousSandoz Inc1984-08-02Not applicableUs
NafcillinPowder, for solution1 g/4mLIntramuscular; IntravenousAPP Pharmaceuticals, LLC2011-06-30Not applicableUs
NafcillinInjection2 g/1Intramuscular; IntravenousClaris Lifesciences, Inc.2012-02-01Not applicableUs
NafcillinInjection, powder, for solution1 g/4mLIntramuscular; IntravenousSagent Pharmaceuticals2012-10-25Not applicableUs
NafcillinInjection, powder, for solution1 g/4mLIntramuscular; IntravenousAuro Medics Pharma Llc2012-12-26Not applicableUs
NafcillinInjection, powder, for solution10 g/100mLIntravenousSandoz Inc1984-08-02Not applicableUs
NafcillinPowder, for solution2 g/8mLIntramuscular; IntravenousAPP Pharmaceuticals, LLC2011-06-30Not applicableUs
NafcillinInjection, powder, for solution1 g/1Intramuscular; IntravenousSandoz Inc1984-08-02Not applicableUs
NafcillinPowder, for solution1 g/1Intramuscular; IntravenousWG Critical Care, LLC2013-01-18Not applicableUs
NafcillinInjection, powder, for solution2 g/8mLIntramuscular; IntravenousSagent Pharmaceuticals2012-10-25Not applicableUs
NafcillinInjection, powder, for solution2 g/8mLIntramuscular; IntravenousAuro Medics Pharma Llc2012-12-26Not applicableUs
NafcillinInjection, powder, for solution10 g/100mLIntravenousAPP Pharmaceuticals, LLC2011-04-27Not applicableUs
NafcillinInjection, powder, for solution2 g/1Intramuscular; IntravenousSandoz Inc1984-08-02Not applicableUs
NafcillinPowder, for solution2 g/1Intramuscular; IntravenousWG Critical Care, LLC2013-01-18Not applicableUs
NafcillinInjection, powder, for solution10 g/100mLIntravenousSagent Pharmaceuticals2012-10-25Not applicableUs
Nafcillin SodiumInjection, powder, for solution1 g/4mLIntramuscular; IntravenousTeva Parenteral Medicines, Inc.2014-04-08Not applicableUs
Nafcillin SodiumInjection, powder, for solution2 g/1IntravenousSandoz Inc2005-09-23Not applicableUs
Nafcillin SodiumInjection, powder, for solution2 g/8mLIntramuscular; IntravenousTeva Parenteral Medicines, Inc.2014-04-09Not applicableUs
Nafcillin SodiumInjection, powder, for solution1 g/1IntravenousSandoz Inc2005-09-23Not applicableUs
Nafcillin SodiumInjection, powder, for solution2 g/1IntravenousSandoz Inc2005-09-23Not applicableUs
Nafcillin SodiumInjection, powder, for solution1 g/1IntravenousSandoz Inc2005-09-23Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
NallpenNot Available
UnipenNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Nafcillin Sodium
985-16-0
Thumb
  • InChI Key: AYAPZOUDXCDGIF-FRFVDRIFSA-M
  • Monoisotopic Mass: 436.106887157
  • Average Mass: 436.457
DBSALT000497
Categories
UNII4CNZ27M7RV
CAS number147-52-4
WeightAverage: 414.475
Monoisotopic: 414.124942514
Chemical FormulaC21H22N2O5S
InChI KeyGPXLMGHLHQJAGZ-JTDSTZFVSA-N
InChI
InChI=1S/C21H22N2O5S/c1-4-28-13-10-9-11-7-5-6-8-12(11)14(13)17(24)22-15-18(25)23-16(20(26)27)21(2,3)29-19(15)23/h5-10,15-16,19H,4H2,1-3H3,(H,22,24)(H,26,27)/t15-,16+,19-/m1/s1
IUPAC Name
(2S,5R,6R)-6-(2-ethoxynaphthalene-1-amido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
SMILES
[H][C@]12SC(C)(C)[C@@H](N1C(=O)[[email protected]]2NC(=O)C1=C(OCC)C=CC2=CC=CC=C12)C(O)=O
Pharmacology
IndicationFor the treatment of infections caused by penicillinase-producing staphylococci which have demonstrated susceptibility to the drugs.
Structured Indications
PharmacodynamicsNafcillin is a semisynthetic antibiotic substance derived from 6-amino-penicillanic acid. The drugs in this class are highly resistant to inactivation by staphylococcal penicillinase and are active against penicillinase-producing and non penicillinase-producing strains of Staphylococcus aureus. The penicillinase- resistant penicillins are active in vitro against a variety of other bacteria.
Mechanism of actionPenicillinase-resistant penicillins exert a bactericidal action against penicillin-susceptible microorganisms during the state of active multiplication. All penicillins inhibit the biosynthesis of the bacterial cell wall.
TargetKindPharmacological actionActionsOrganismUniProt ID
Penicillin-binding protein 1bProteinyes
inhibitor
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)Q7CRA4 details
Penicillin-binding protein 2BProteinyes
inhibitor
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)P0A3M6 details
Penicillin-binding protein 2aProteinyes
inhibitor
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)Q8DNB6 details
Penicillin-binding protein 3Proteinyes
inhibitor
Streptococcus pneumoniaeQ75Y35 details
Penicillin-binding protein 1AProteinyes
inhibitor
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)Q8DR59 details
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein binding89.9 ±1.5%
Metabolism

Hepatic metabolism accounts for less than 30% of the biotransformation of most penicillins.

Route of eliminationNafcillin is primarily eliminated by nonrenal routes, namely hepatic inactivation and excretion in the bile.
Half lifeThe serum half-life of nafcillin administered by the intravenous route ranged from 33 to 61 minutes as measured in three separate studies.
ClearanceNot Available
ToxicitySerious toxicity is unlikely following large doses of nafcillin. Acute ingestion of large doses of nafcillin may cause nausea, vomiting, diarrhea and abdominal pain. Acute oliguric renal failure and hematuria may occur following large doses.
Affected organisms
  • Enteric bacteria and other eubacteria
  • Staphylococcus aureus
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
AbirateroneThe serum concentration of Abiraterone can be decreased when it is combined with Nafcillin.Approved
AcenocoumarolNafcillin may decrease the anticoagulant activities of Acenocoumarol.Approved
AcetaminophenThe serum concentration of Acetaminophen can be decreased when it is combined with Nafcillin.Approved
AclarubicinThe serum concentration of Aclarubicin can be decreased when it is combined with Nafcillin.Investigational
AdinazolamThe serum concentration of Adinazolam can be decreased when it is combined with Nafcillin.Approved
AlbendazoleThe serum concentration of Albendazole can be decreased when it is combined with Nafcillin.Approved, Vet Approved
AlclometasoneThe serum concentration of Alclometasone can be decreased when it is combined with Nafcillin.Approved
AlfentanilThe serum concentration of Alfentanil can be decreased when it is combined with Nafcillin.Approved, Illicit
AlfuzosinThe serum concentration of Alfuzosin can be decreased when it is combined with Nafcillin.Approved, Investigational
AliskirenThe serum concentration of Aliskiren can be decreased when it is combined with Nafcillin.Approved, Investigational
AllylestrenolThe serum concentration of Allylestrenol can be decreased when it is combined with Nafcillin.Approved
AlmotriptanThe serum concentration of Almotriptan can be decreased when it is combined with Nafcillin.Approved, Investigational
AlogliptinThe serum concentration of Alogliptin can be decreased when it is combined with Nafcillin.Approved
AlosetronThe serum concentration of Alosetron can be decreased when it is combined with Nafcillin.Approved, Withdrawn
AlprazolamThe serum concentration of Alprazolam can be decreased when it is combined with Nafcillin.Approved, Illicit, Investigational
AmbrisentanThe serum concentration of Ambrisentan can be decreased when it is combined with Nafcillin.Approved, Investigational
AmbroxolThe serum concentration of Ambroxol can be decreased when it is combined with Nafcillin.Approved
AmikacinThe serum concentration of Amikacin can be decreased when it is combined with Nafcillin.Approved, Vet Approved
AminophenazoneThe serum concentration of Aminophenazone can be decreased when it is combined with Nafcillin.Approved, Withdrawn
AminophyllineThe serum concentration of Aminophylline can be decreased when it is combined with Nafcillin.Approved
AmiodaroneThe serum concentration of Amiodarone can be decreased when it is combined with Nafcillin.Approved, Investigational
AmitriptylineThe serum concentration of Amitriptyline can be decreased when it is combined with Nafcillin.Approved
AmlodipineThe metabolism of Amlodipine can be increased when combined with Nafcillin.Approved
AmprenavirThe serum concentration of Amprenavir can be decreased when it is combined with Nafcillin.Approved
AmrinoneThe metabolism of Amrinone can be increased when combined with Nafcillin.Approved
AmrubicinThe serum concentration of Amrubicin can be decreased when it is combined with Nafcillin.Approved, Investigational
annamycinThe serum concentration of annamycin can be decreased when it is combined with Nafcillin.Investigational
AntipyrineThe serum concentration of Antipyrine can be decreased when it is combined with Nafcillin.Approved
ApixabanThe serum concentration of Apixaban can be decreased when it is combined with Nafcillin.Approved
ApramycinThe serum concentration of Apramycin can be decreased when it is combined with Nafcillin.Experimental, Vet Approved
ApremilastThe serum concentration of Apremilast can be decreased when it is combined with Nafcillin.Approved, Investigational
AprepitantThe serum concentration of Aprepitant can be decreased when it is combined with Nafcillin.Approved, Investigational
ArbekacinThe serum concentration of Arbekacin can be decreased when it is combined with Nafcillin.Approved
ArgatrobanThe serum concentration of Argatroban can be decreased when it is combined with Nafcillin.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Nafcillin.Approved, Investigational
ArtemetherThe serum concentration of Artemether can be decreased when it is combined with Nafcillin.Approved
AsenapineThe serum concentration of Asenapine can be decreased when it is combined with Nafcillin.Approved
AstemizoleThe serum concentration of Astemizole can be decreased when it is combined with Nafcillin.Approved, Withdrawn
AtazanavirThe serum concentration of Atazanavir can be decreased when it is combined with Nafcillin.Approved, Investigational
AtorvastatinThe serum concentration of Atorvastatin can be decreased when it is combined with Nafcillin.Approved
AvanafilThe serum concentration of Avanafil can be decreased when it is combined with Nafcillin.Approved
AxitinibThe serum concentration of Axitinib can be decreased when it is combined with Nafcillin.Approved, Investigational
AzelastineThe serum concentration of Azelastine can be decreased when it is combined with Nafcillin.Approved
AzelnidipineThe metabolism of Azelnidipine can be increased when combined with Nafcillin.Approved
AzimilideThe metabolism of Azimilide can be increased when combined with Nafcillin.Investigational
AzithromycinThe serum concentration of Azithromycin can be decreased when it is combined with Nafcillin.Approved
BanoxantroneThe serum concentration of Banoxantrone can be decreased when it is combined with Nafcillin.Investigational
BarnidipineThe metabolism of Barnidipine can be increased when combined with Nafcillin.Approved
BcgThe therapeutic efficacy of Bcg can be decreased when used in combination with Nafcillin.Investigational
BedaquilineThe serum concentration of Bedaquiline can be decreased when it is combined with Nafcillin.Approved
BenidipineThe metabolism of Benidipine can be increased when combined with Nafcillin.Approved
BenzphetamineThe serum concentration of Benzphetamine can be decreased when it is combined with Nafcillin.Approved, Illicit
Benzyl alcoholThe serum concentration of Benzyl alcohol can be decreased when it is combined with Nafcillin.Approved
BepridilThe metabolism of Bepridil can be increased when combined with Nafcillin.Approved, Withdrawn
BexaroteneThe serum concentration of Bexarotene can be decreased when it is combined with Nafcillin.Approved, Investigational
BezafibrateThe serum concentration of Bezafibrate can be decreased when it is combined with Nafcillin.Approved
BicalutamideThe serum concentration of Bicalutamide can be decreased when it is combined with Nafcillin.Approved
BisoprololThe serum concentration of Bisoprolol can be decreased when it is combined with Nafcillin.Approved
BoceprevirThe serum concentration of Boceprevir can be decreased when it is combined with Nafcillin.Approved
BortezomibThe serum concentration of Bortezomib can be decreased when it is combined with Nafcillin.Approved, Investigational
BosentanThe serum concentration of Bosentan can be decreased when it is combined with Nafcillin.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be decreased when it is combined with Nafcillin.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be decreased when it is combined with Nafcillin.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be decreased when it is combined with Nafcillin.Approved
BrinzolamideThe serum concentration of Brinzolamide can be decreased when it is combined with Nafcillin.Approved
BromazepamThe serum concentration of Bromazepam can be decreased when it is combined with Nafcillin.Approved, Illicit
BromocriptineThe serum concentration of Bromocriptine can be decreased when it is combined with Nafcillin.Approved, Investigational
BrompheniramineThe serum concentration of Brompheniramine can be decreased when it is combined with Nafcillin.Approved
BudesonideThe serum concentration of Budesonide can be decreased when it is combined with Nafcillin.Approved
BupivacaineThe serum concentration of Bupivacaine can be decreased when it is combined with Nafcillin.Approved, Investigational
BuprenorphineThe serum concentration of Buprenorphine can be decreased when it is combined with Nafcillin.Approved, Illicit, Investigational, Vet Approved
BupropionThe serum concentration of Bupropion can be decreased when it is combined with Nafcillin.Approved
BuspironeThe serum concentration of Buspirone can be decreased when it is combined with Nafcillin.Approved, Investigational
BusulfanThe serum concentration of Busulfan can be decreased when it is combined with Nafcillin.Approved, Investigational
CabazitaxelThe serum concentration of Cabazitaxel can be decreased when it is combined with Nafcillin.Approved
CabergolineThe serum concentration of Cabergoline can be decreased when it is combined with Nafcillin.Approved
CabozantinibThe serum concentration of Cabozantinib can be decreased when it is combined with Nafcillin.Approved
CaffeineThe serum concentration of Caffeine can be decreased when it is combined with Nafcillin.Approved
CaiThe metabolism of Cai can be increased when combined with Nafcillin.Investigational
CalcitriolThe serum concentration of Calcitriol can be decreased when it is combined with Nafcillin.Approved, Nutraceutical
CanagliflozinThe serum concentration of Canagliflozin can be decreased when it is combined with Nafcillin.Approved
CarbamazepineThe serum concentration of Carbamazepine can be decreased when it is combined with Nafcillin.Approved, Investigational
CarbinoxamineThe serum concentration of Carbinoxamine can be decreased when it is combined with Nafcillin.Approved
CariprazineThe serum concentration of Cariprazine can be decreased when it is combined with Nafcillin.Approved
CarvedilolThe serum concentration of Carvedilol can be decreased when it is combined with Nafcillin.Approved, Investigational
CelecoxibThe serum concentration of Celecoxib can be decreased when it is combined with Nafcillin.Approved, Investigational
CeliprololThe serum concentration of Celiprolol can be decreased when it is combined with Nafcillin.Approved, Investigational
CephalexinThe serum concentration of Cephalexin can be decreased when it is combined with Nafcillin.Approved, Vet Approved
CerivastatinThe serum concentration of Cerivastatin can be decreased when it is combined with Nafcillin.Withdrawn
CevimelineThe serum concentration of Cevimeline can be decreased when it is combined with Nafcillin.Approved
Chenodeoxycholic acidThe serum concentration of Chenodeoxycholic acid can be decreased when it is combined with Nafcillin.Approved
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Nafcillin.Approved, Illicit
ChloroquineThe serum concentration of Chloroquine can be decreased when it is combined with Nafcillin.Approved, Vet Approved
ChlorotrianiseneThe metabolism of Chlorotrianisene can be increased when combined with Nafcillin.Withdrawn
ChlorphenamineThe serum concentration of Chlorphenamine can be decreased when it is combined with Nafcillin.Approved
ChlorpromazineThe serum concentration of Chlorpromazine can be decreased when it is combined with Nafcillin.Approved, Vet Approved
ChlortetracyclineThe therapeutic efficacy of Nafcillin can be decreased when used in combination with Chlortetracycline.Approved, Vet Approved
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be decreased when it is combined with Nafcillin.Approved
CholecalciferolThe serum concentration of Cholecalciferol can be decreased when it is combined with Nafcillin.Approved, Nutraceutical
CiclesonideThe serum concentration of Ciclesonide can be decreased when it is combined with Nafcillin.Approved, Investigational
CilnidipineThe metabolism of Cilnidipine can be increased when combined with Nafcillin.Approved
CilostazolThe serum concentration of Cilostazol can be decreased when it is combined with Nafcillin.Approved
CinacalcetThe serum concentration of Cinacalcet can be decreased when it is combined with Nafcillin.Approved
CinnarizineThe metabolism of Cinnarizine can be increased when combined with Nafcillin.Approved
CisaprideThe serum concentration of Cisapride can be decreased when it is combined with Nafcillin.Approved, Investigational, Withdrawn
CitalopramThe serum concentration of Citalopram can be decreased when it is combined with Nafcillin.Approved
ClarithromycinThe serum concentration of the active metabolites of Clarithromycin can be increased when Clarithromycin is used in combination with Nafcillin.Approved
ClevidipineThe metabolism of Clevidipine can be increased when combined with Nafcillin.Approved
ClindamycinThe serum concentration of Clindamycin can be decreased when it is combined with Nafcillin.Approved, Vet Approved
ClobazamThe serum concentration of Clobazam can be decreased when it is combined with Nafcillin.Approved, Illicit
ClofazimineThe serum concentration of Clofazimine can be decreased when it is combined with Nafcillin.Approved, Investigational
ClofibrateThe serum concentration of Clofibrate can be decreased when it is combined with Nafcillin.Approved
clomethiazoleThe serum concentration of clomethiazole can be decreased when it is combined with Nafcillin.Investigational
ClomipramineThe serum concentration of Clomipramine can be decreased when it is combined with Nafcillin.Approved, Vet Approved
ClonazepamThe serum concentration of Clonazepam can be decreased when it is combined with Nafcillin.Approved, Illicit
ClonidineThe serum concentration of Clonidine can be decreased when it is combined with Nafcillin.Approved
ClopidogrelThe serum concentration of Clopidogrel can be decreased when it is combined with Nafcillin.Approved, Nutraceutical
ClorazepateThe serum concentration of Clorazepate can be decreased when it is combined with Nafcillin.Approved, Illicit
ClotiazepamThe serum concentration of Clotiazepam can be decreased when it is combined with Nafcillin.Approved, Illicit
ClozapineThe serum concentration of Clozapine can be decreased when it is combined with Nafcillin.Approved
CobimetinibThe serum concentration of Cobimetinib can be decreased when it is combined with Nafcillin.Approved
CocaineThe serum concentration of Cocaine can be decreased when it is combined with Nafcillin.Approved, Illicit
CodeineThe serum concentration of Codeine can be decreased when it is combined with Nafcillin.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be decreased when it is combined with Nafcillin.Approved
ConivaptanThe serum concentration of Conivaptan can be decreased when it is combined with Nafcillin.Approved, Investigational
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be increased when combined with Nafcillin.Approved
Cortisone acetateThe serum concentration of Cortisone acetate can be decreased when it is combined with Nafcillin.Approved
CrizotinibThe serum concentration of Crizotinib can be decreased when it is combined with Nafcillin.Approved
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be decreased when it is combined with Nafcillin.Approved
CyclophosphamideThe serum concentration of Cyclophosphamide can be decreased when it is combined with Nafcillin.Approved, Investigational
CyclosporineThe metabolism of Cyclosporine can be increased when combined with Nafcillin.Approved, Investigational, Vet Approved
CyclosporineThe serum concentration of Cyclosporine can be decreased when it is combined with Nafcillin.Approved, Investigational, Vet Approved
CytarabineThe serum concentration of Cytarabine can be decreased when it is combined with Nafcillin.Approved, Investigational
DabrafenibThe serum concentration of Dabrafenib can be decreased when it is combined with Nafcillin.Approved
DaclatasvirThe serum concentration of Daclatasvir can be decreased when it is combined with Nafcillin.Approved
DantroleneThe serum concentration of Dantrolene can be decreased when it is combined with Nafcillin.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be decreased when it is combined with Nafcillin.Approved
DapsoneThe serum concentration of Dapsone can be decreased when it is combined with Nafcillin.Approved, Investigational
DarifenacinThe serum concentration of Darifenacin can be decreased when it is combined with Nafcillin.Approved, Investigational
DarodipineThe metabolism of Darodipine can be increased when combined with Nafcillin.Experimental
DarunavirThe serum concentration of Darunavir can be decreased when it is combined with Nafcillin.Approved
DasabuvirThe serum concentration of Dasabuvir can be decreased when it is combined with Nafcillin.Approved
DasatinibThe serum concentration of Dasatinib can be decreased when it is combined with Nafcillin.Approved, Investigational
DaunorubicinThe serum concentration of Daunorubicin can be decreased when it is combined with Nafcillin.Approved
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Nafcillin.Approved
DemeclocyclineThe therapeutic efficacy of Nafcillin can be decreased when used in combination with Demeclocycline.Approved
DesvenlafaxineThe serum concentration of Desvenlafaxine can be decreased when it is combined with Nafcillin.Approved
DexamethasoneThe serum concentration of Dexamethasone can be decreased when it is combined with Nafcillin.Approved, Investigational, Vet Approved
DextromethorphanThe serum concentration of Dextromethorphan can be decreased when it is combined with Nafcillin.Approved
DextropropoxypheneThe serum concentration of Dextropropoxyphene can be decreased when it is combined with Nafcillin.Approved, Illicit, Withdrawn
DiazepamThe serum concentration of Diazepam can be decreased when it is combined with Nafcillin.Approved, Illicit, Vet Approved
DiclofenacThe serum concentration of Diclofenac can be decreased when it is combined with Nafcillin.Approved, Vet Approved
DicoumarolNafcillin may decrease the anticoagulant activities of Dicoumarol.Approved
DienestrolThe metabolism of Dienestrol can be increased when combined with Nafcillin.Approved
DiethylstilbestrolThe metabolism of Diethylstilbestrol can be increased when combined with Nafcillin.Approved
DigitoxinThe serum concentration of Digitoxin can be decreased when it is combined with Nafcillin.Approved
DigoxinThe serum concentration of Digoxin can be decreased when it is combined with Nafcillin.Approved
DihydrocodeineThe serum concentration of Dihydrocodeine can be decreased when it is combined with Nafcillin.Approved, Illicit
DihydroergotamineThe serum concentration of Dihydroergotamine can be decreased when it is combined with Nafcillin.Approved
DihydrostreptomycinThe serum concentration of Dihydrostreptomycin can be decreased when it is combined with Nafcillin.Vet Approved
DiltiazemThe metabolism of Diltiazem can be increased when combined with Nafcillin.Approved
DisopyramideThe serum concentration of Disopyramide can be decreased when it is combined with Nafcillin.Approved
DisulfiramThe serum concentration of Disulfiram can be decreased when it is combined with Nafcillin.Approved
DocetaxelThe serum concentration of Docetaxel can be decreased when it is combined with Nafcillin.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be decreased when it is combined with Nafcillin.Approved
DolasetronThe serum concentration of Dolasetron can be decreased when it is combined with Nafcillin.Approved
DomperidoneThe serum concentration of Domperidone can be decreased when it is combined with Nafcillin.Approved, Investigational, Vet Approved
DonepezilThe serum concentration of Donepezil can be decreased when it is combined with Nafcillin.Approved
DorzolamideThe serum concentration of Dorzolamide can be decreased when it is combined with Nafcillin.Approved
DotarizineThe metabolism of Dotarizine can be increased when combined with Nafcillin.Investigational
DoxepinThe serum concentration of Doxepin can be decreased when it is combined with Nafcillin.Approved
DoxorubicinThe serum concentration of Doxorubicin can be decreased when it is combined with Nafcillin.Approved, Investigational
DoxycyclineThe therapeutic efficacy of Nafcillin can be decreased when used in combination with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be decreased when it is combined with Nafcillin.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be decreased when it is combined with Nafcillin.Approved
DutasterideThe serum concentration of Dutasteride can be decreased when it is combined with Nafcillin.Approved, Investigational
EfavirenzThe serum concentration of Efavirenz can be decreased when it is combined with Nafcillin.Approved, Investigational
EfonidipineThe metabolism of Efonidipine can be increased when combined with Nafcillin.Approved
EletriptanThe serum concentration of Eletriptan can be decreased when it is combined with Nafcillin.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be decreased when it is combined with Nafcillin.Approved
ElvitegravirThe serum concentration of Elvitegravir can be decreased when it is combined with Nafcillin.Approved
EnalaprilThe serum concentration of Enalapril can be decreased when it is combined with Nafcillin.Approved, Vet Approved
EnzalutamideThe serum concentration of Enzalutamide can be decreased when it is combined with Nafcillin.Approved
EperisoneThe metabolism of Eperisone can be increased when combined with Nafcillin.Approved, Investigational
EpinastineThe serum concentration of Epinastine can be decreased when it is combined with Nafcillin.Approved, Investigational
EpirubicinThe serum concentration of Epirubicin can be decreased when it is combined with Nafcillin.Approved
EplerenoneThe serum concentration of Eplerenone can be decreased when it is combined with Nafcillin.Approved
ErgocalciferolThe serum concentration of Ergocalciferol can be decreased when it is combined with Nafcillin.Approved, Nutraceutical
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be decreased when it is combined with Nafcillin.Approved
ErgonovineThe serum concentration of Ergonovine can be decreased when it is combined with Nafcillin.Approved
ErgotamineThe serum concentration of Ergotamine can be decreased when it is combined with Nafcillin.Approved
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with Nafcillin.Approved, Investigational
ErythromycinThe serum concentration of Erythromycin can be decreased when it is combined with Nafcillin.Approved, Vet Approved
EscitalopramThe serum concentration of Escitalopram can be decreased when it is combined with Nafcillin.Approved, Investigational
EsomeprazoleThe serum concentration of Esomeprazole can be decreased when it is combined with Nafcillin.Approved, Investigational
EstazolamThe serum concentration of Estazolam can be decreased when it is combined with Nafcillin.Approved, Illicit
EstradiolThe metabolism of Estradiol can be increased when combined with Nafcillin.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe serum concentration of Estradiol valerate/Dienogest can be decreased when it is combined with Nafcillin.Approved
EstramustineThe metabolism of Estramustine can be increased when combined with Nafcillin.Approved
Estrogens, esterifiedThe metabolism of Estrogens, esterified can be increased when combined with Nafcillin.Approved
EstroneThe serum concentration of Estrone can be decreased when it is combined with Nafcillin.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be increased when combined with Nafcillin.Approved
EszopicloneThe serum concentration of Eszopiclone can be decreased when it is combined with Nafcillin.Approved
EthanolThe serum concentration of Ethanol can be decreased when it is combined with Nafcillin.Approved
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be increased when combined with Nafcillin.Approved
EthosuximideThe serum concentration of Ethosuximide can be decreased when it is combined with Nafcillin.Approved
Ethyl biscoumacetateNafcillin may decrease the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
EthylmorphineThe serum concentration of Ethylmorphine can be decreased when it is combined with Nafcillin.Approved, Illicit
EtonogestrelThe serum concentration of Etonogestrel can be decreased when it is combined with Nafcillin.Approved, Investigational
EtoposideThe serum concentration of Etoposide can be decreased when it is combined with Nafcillin.Approved
EtoricoxibThe serum concentration of Etoricoxib can be decreased when it is combined with Nafcillin.Approved, Investigational
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Nafcillin.Approved
EverolimusThe serum concentration of Everolimus can be decreased when it is combined with Nafcillin.Approved
ExemestaneThe serum concentration of Exemestane can be decreased when it is combined with Nafcillin.Approved, Investigational
FamciclovirThe serum concentration of Famciclovir can be decreased when it is combined with Nafcillin.Approved
FelbamateThe serum concentration of Felbamate can be decreased when it is combined with Nafcillin.Approved
FelodipineThe metabolism of Felodipine can be increased when combined with Nafcillin.Approved, Investigational
FendilineThe metabolism of Fendiline can be increased when combined with Nafcillin.Withdrawn
FenofibrateThe serum concentration of Fenofibrate can be decreased when it is combined with Nafcillin.Approved
FentanylThe serum concentration of Fentanyl can be decreased when it is combined with Nafcillin.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of Fesoterodine can be decreased when it is combined with Nafcillin.Approved
FinasterideThe serum concentration of Finasteride can be decreased when it is combined with Nafcillin.Approved
FingolimodThe serum concentration of Fingolimod can be decreased when it is combined with Nafcillin.Approved, Investigational
FlibanserinThe serum concentration of Flibanserin can be decreased when it is combined with Nafcillin.Approved
FluindioneNafcillin may decrease the anticoagulant activities of Fluindione.Investigational
FlunarizineThe metabolism of Flunarizine can be increased when combined with Nafcillin.Approved
FlunisolideThe serum concentration of Flunisolide can be decreased when it is combined with Nafcillin.Approved, Investigational
FlunitrazepamThe serum concentration of Flunitrazepam can be decreased when it is combined with Nafcillin.Approved, Illicit
FluorometholoneThe serum concentration of Fluorometholone can be decreased when it is combined with Nafcillin.Approved
FluoxetineThe serum concentration of Fluoxetine can be decreased when it is combined with Nafcillin.Approved, Vet Approved
FlurazepamThe serum concentration of Flurazepam can be decreased when it is combined with Nafcillin.Approved, Illicit
FlutamideThe serum concentration of Flutamide can be decreased when it is combined with Nafcillin.Approved
Fluticasone furoateThe serum concentration of Fluticasone furoate can be decreased when it is combined with Nafcillin.Approved
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be decreased when it is combined with Nafcillin.Approved
FluvastatinThe serum concentration of Fluvastatin can be decreased when it is combined with Nafcillin.Approved
FosamprenavirThe serum concentration of Fosamprenavir can be decreased when it is combined with Nafcillin.Approved
FramycetinThe serum concentration of Framycetin can be decreased when it is combined with Nafcillin.Approved
FulvestrantThe serum concentration of Fulvestrant can be decreased when it is combined with Nafcillin.Approved, Investigational
GabapentinThe metabolism of Gabapentin can be increased when combined with Nafcillin.Approved, Investigational
GalantamineThe serum concentration of Galantamine can be decreased when it is combined with Nafcillin.Approved
GallopamilThe metabolism of Gallopamil can be increased when combined with Nafcillin.Investigational
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with Nafcillin.Approved, Investigational
GemfibrozilThe serum concentration of Gemfibrozil can be decreased when it is combined with Nafcillin.Approved
GeneticinThe serum concentration of Geneticin can be decreased when it is combined with Nafcillin.Experimental
GentamicinThe serum concentration of Gentamicin can be decreased when it is combined with Nafcillin.Approved, Vet Approved
GENTAMICIN C1AThe serum concentration of GENTAMICIN C1A can be decreased when it is combined with Nafcillin.Experimental
GlipizideThe serum concentration of Glipizide can be decreased when it is combined with Nafcillin.Approved
GlyburideThe serum concentration of Glyburide can be decreased when it is combined with Nafcillin.Approved
GranisetronThe serum concentration of Granisetron can be decreased when it is combined with Nafcillin.Approved, Investigational
GrepafloxacinThe serum concentration of Grepafloxacin can be decreased when it is combined with Nafcillin.Withdrawn
GuanfacineThe serum concentration of Guanfacine can be decreased when it is combined with Nafcillin.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be decreased when it is combined with Nafcillin.Approved
HaloperidolThe serum concentration of Haloperidol can be decreased when it is combined with Nafcillin.Approved
HalothaneThe serum concentration of Halothane can be decreased when it is combined with Nafcillin.Approved, Vet Approved
HexestrolThe metabolism of Hexestrol can be increased when combined with Nafcillin.Withdrawn
HexobarbitalThe serum concentration of Hexobarbital can be decreased when it is combined with Nafcillin.Approved
Histamine PhosphateThe serum concentration of Histamine Phosphate can be decreased when it is combined with Nafcillin.Approved
HydrocodoneThe serum concentration of Hydrocodone can be decreased when it is combined with Nafcillin.Approved, Illicit
HydrocortisoneThe serum concentration of Hydrocortisone can be decreased when it is combined with Nafcillin.Approved, Vet Approved
HydromorphoneThe serum concentration of Hydromorphone can be decreased when it is combined with Nafcillin.Approved, Illicit
Hydroxyprogesterone caproateThe serum concentration of Hydroxyprogesterone caproate can be decreased when it is combined with Nafcillin.Approved
Hygromycin BThe serum concentration of Hygromycin B can be decreased when it is combined with Nafcillin.Vet Approved
IbrutinibThe serum concentration of Ibrutinib can be decreased when it is combined with Nafcillin.Approved
IdarubicinThe serum concentration of Idarubicin can be decreased when it is combined with Nafcillin.Approved
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Nafcillin resulting in a loss in efficacy.Approved
IloperidoneThe serum concentration of Iloperidone can be decreased when it is combined with Nafcillin.Approved
ImatinibThe serum concentration of Imatinib can be decreased when it is combined with Nafcillin.Approved
ImipramineThe serum concentration of Imipramine can be decreased when it is combined with Nafcillin.Approved
ImiquimodThe serum concentration of Imiquimod can be decreased when it is combined with Nafcillin.Approved, Investigational
IndacaterolThe serum concentration of Indacaterol can be decreased when it is combined with Nafcillin.Approved
IndapamideThe serum concentration of Indapamide can be decreased when it is combined with Nafcillin.Approved
IndinavirThe serum concentration of Indinavir can be decreased when it is combined with Nafcillin.Approved
INNO-206The serum concentration of INNO-206 can be decreased when it is combined with Nafcillin.Investigational
Ipratropium bromideThe serum concentration of Ipratropium bromide can be decreased when it is combined with Nafcillin.Approved
IrinotecanThe serum concentration of Irinotecan can be decreased when it is combined with Nafcillin.Approved, Investigational
IsavuconazoniumThe serum concentration of Isavuconazonium can be decreased when it is combined with Nafcillin.Approved, Investigational
Isosorbide DinitrateThe serum concentration of Isosorbide Dinitrate can be decreased when it is combined with Nafcillin.Approved
Isosorbide MononitrateThe serum concentration of Isosorbide Mononitrate can be decreased when it is combined with Nafcillin.Approved
IsradipineThe metabolism of Isradipine can be increased when combined with Nafcillin.Approved
ItraconazoleThe serum concentration of Itraconazole can be decreased when it is combined with Nafcillin.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be decreased when it is combined with Nafcillin.Approved
IvacaftorThe serum concentration of Ivacaftor can be decreased when it is combined with Nafcillin.Approved
IvermectinThe serum concentration of Ivermectin can be decreased when it is combined with Nafcillin.Approved, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be decreased when it is combined with Nafcillin.Approved, Investigational
IxazomibThe serum concentration of Ixazomib can be decreased when it is combined with Nafcillin.Approved
KanamycinThe serum concentration of Kanamycin can be decreased when it is combined with Nafcillin.Approved, Vet Approved
KetamineThe serum concentration of Ketamine can be decreased when it is combined with Nafcillin.Approved, Vet Approved
KetazolamThe serum concentration of Ketazolam can be decreased when it is combined with Nafcillin.Approved
KetobemidoneThe serum concentration of Ketobemidone can be decreased when it is combined with Nafcillin.Approved
KetoconazoleThe serum concentration of Ketoconazole can be decreased when it is combined with Nafcillin.Approved, Investigational
LacidipineThe metabolism of Lacidipine can be increased when combined with Nafcillin.Approved
LamotrigineThe metabolism of Lamotrigine can be increased when combined with Nafcillin.Approved, Investigational
LansoprazoleThe serum concentration of Lansoprazole can be decreased when it is combined with Nafcillin.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be decreased when it is combined with Nafcillin.Approved, Investigational
LaquinimodThe serum concentration of Laquinimod can be decreased when it is combined with Nafcillin.Investigational
LenvatinibThe serum concentration of Lenvatinib can be decreased when it is combined with Nafcillin.Approved
LercanidipineThe metabolism of Lercanidipine can be increased when combined with Nafcillin.Approved, Investigational
LetrozoleThe serum concentration of Letrozole can be decreased when it is combined with Nafcillin.Approved, Investigational
LevobupivacaineThe serum concentration of Levobupivacaine can be decreased when it is combined with Nafcillin.Approved
LevocetirizineThe serum concentration of Levocetirizine can be decreased when it is combined with Nafcillin.Approved
Levomethadyl AcetateThe serum concentration of Levomethadyl Acetate can be decreased when it is combined with Nafcillin.Approved
LevomilnacipranThe serum concentration of Levomilnacipran can be decreased when it is combined with Nafcillin.Approved
LevonorgestrelThe serum concentration of Levonorgestrel can be decreased when it is combined with Nafcillin.Approved, Investigational
LevothyroxineThe serum concentration of Levothyroxine can be decreased when it is combined with Nafcillin.Approved
LidocaineThe serum concentration of Lidocaine can be decreased when it is combined with Nafcillin.Approved, Vet Approved
LisurideThe serum concentration of Lisuride can be decreased when it is combined with Nafcillin.Approved
LomitapideThe serum concentration of Lomitapide can be decreased when it is combined with Nafcillin.Approved
LoperamideThe serum concentration of Loperamide can be decreased when it is combined with Nafcillin.Approved
LopinavirThe serum concentration of Lopinavir can be decreased when it is combined with Nafcillin.Approved
LoratadineThe serum concentration of Loratadine can be decreased when it is combined with Nafcillin.Approved
LorcaserinThe serum concentration of Lorcaserin can be decreased when it is combined with Nafcillin.Approved
LosartanThe serum concentration of Losartan can be decreased when it is combined with Nafcillin.Approved
LovastatinThe serum concentration of Lovastatin can be decreased when it is combined with Nafcillin.Approved, Investigational
LumefantrineThe serum concentration of Lumefantrine can be decreased when it is combined with Nafcillin.Approved
LurasidoneThe serum concentration of Lurasidone can be decreased when it is combined with Nafcillin.Approved
MacitentanThe serum concentration of Macitentan can be decreased when it is combined with Nafcillin.Approved
Magnesium SulfateThe metabolism of Magnesium Sulfate can be increased when combined with Nafcillin.Approved, Vet Approved
ManidipineThe metabolism of Manidipine can be increased when combined with Nafcillin.Approved
MaravirocThe serum concentration of Maraviroc can be decreased when it is combined with Nafcillin.Approved, Investigational
MebendazoleThe serum concentration of Mebendazole can be decreased when it is combined with Nafcillin.Approved, Vet Approved
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Nafcillin.Approved, Investigational
MefloquineThe serum concentration of Mefloquine can be decreased when it is combined with Nafcillin.Approved
MeloxicamThe serum concentration of Meloxicam can be decreased when it is combined with Nafcillin.Approved, Vet Approved
MestranolThe metabolism of Mestranol can be increased when combined with Nafcillin.Approved
MethadoneThe serum concentration of Methadone can be decreased when it is combined with Nafcillin.Approved
MethallenestrilThe metabolism of Methallenestril can be increased when combined with Nafcillin.Experimental
MethaqualoneThe serum concentration of Methaqualone can be decreased when it is combined with Nafcillin.Illicit, Withdrawn
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Nafcillin.Approved
MethoxsalenThe serum concentration of Methoxsalen can be decreased when it is combined with Nafcillin.Approved
MethoxyfluraneThe serum concentration of Methoxyflurane can be decreased when it is combined with Nafcillin.Approved, Vet Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be decreased when it is combined with Nafcillin.Approved, Vet Approved
MethyltestosteroneThe serum concentration of Methyltestosterone can be decreased when it is combined with Nafcillin.Approved
MetrizamideThe serum concentration of Metrizamide can be decreased when it is combined with Nafcillin.Approved
MetronidazoleThe serum concentration of Metronidazole can be decreased when it is combined with Nafcillin.Approved
MexiletineThe serum concentration of Mexiletine can be decreased when it is combined with Nafcillin.Approved
MianserinThe serum concentration of Mianserin can be decreased when it is combined with Nafcillin.Approved
MibefradilThe metabolism of Mibefradil can be increased when combined with Nafcillin.Withdrawn
MiconazoleThe serum concentration of Miconazole can be decreased when it is combined with Nafcillin.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Midazolam can be decreased when it is combined with Nafcillin.Approved, Illicit
MifepristoneThe serum concentration of Mifepristone can be decreased when it is combined with Nafcillin.Approved, Investigational
MinocyclineThe therapeutic efficacy of Nafcillin can be decreased when used in combination with Minocycline.Approved, Investigational
MirabegronThe serum concentration of Mirabegron can be decreased when it is combined with Nafcillin.Approved
MirtazapineThe serum concentration of Mirtazapine can be decreased when it is combined with Nafcillin.Approved
ModafinilThe serum concentration of Modafinil can be decreased when it is combined with Nafcillin.Approved, Investigational
MontelukastThe serum concentration of Montelukast can be decreased when it is combined with Nafcillin.Approved
MorphineThe serum concentration of Morphine can be decreased when it is combined with Nafcillin.Approved, Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be decreased when it is combined with Nafcillin.Approved, Investigational
Mycophenolic acidThe serum concentration of the active metabolites of Mycophenolic acid can be reduced when Mycophenolic acid is used in combination with Nafcillin resulting in a loss in efficacy.Approved
NaftopidilThe metabolism of Naftopidil can be increased when combined with Nafcillin.Investigational
NaloxegolThe serum concentration of Naloxegol can be decreased when it is combined with Nafcillin.Approved
NaloxoneThe serum concentration of Naloxone can be decreased when it is combined with Nafcillin.Approved, Vet Approved
NateglinideThe serum concentration of Nateglinide can be decreased when it is combined with Nafcillin.Approved, Investigational
NeamineThe serum concentration of Neamine can be decreased when it is combined with Nafcillin.Experimental
NefazodoneThe serum concentration of Nefazodone can be decreased when it is combined with Nafcillin.Approved, Withdrawn
NelfinavirThe serum concentration of Nelfinavir can be decreased when it is combined with Nafcillin.Approved
NeomycinThe serum concentration of Neomycin can be decreased when it is combined with Nafcillin.Approved, Vet Approved
NetilmicinThe serum concentration of Netilmicin can be decreased when it is combined with Nafcillin.Approved
NevirapineThe serum concentration of Nevirapine can be decreased when it is combined with Nafcillin.Approved
NicardipineThe metabolism of Nicardipine can be increased when combined with Nafcillin.Approved
NicotineThe serum concentration of Nicotine can be decreased when it is combined with Nafcillin.Approved
NifedipineThe metabolism of Nifedipine can be increased when combined with Nafcillin.Approved
NiguldipineThe metabolism of Niguldipine can be increased when combined with Nafcillin.Experimental
NilotinibThe serum concentration of Nilotinib can be decreased when it is combined with Nafcillin.Approved, Investigational
NiludipineThe metabolism of Niludipine can be increased when combined with Nafcillin.Experimental
NilvadipineThe metabolism of Nilvadipine can be increased when combined with Nafcillin.Approved
NimesulideThe metabolism of Nimesulide can be increased when combined with Nafcillin.Approved, Withdrawn
NimodipineThe metabolism of Nimodipine can be increased when combined with Nafcillin.Approved
NisoldipineThe serum concentration of Nisoldipine can be decreased when it is combined with Nafcillin.Approved
NitrazepamThe serum concentration of Nitrazepam can be decreased when it is combined with Nafcillin.Approved
NitrendipineThe metabolism of Nitrendipine can be increased when combined with Nafcillin.Approved
NorethisteroneThe serum concentration of Norethisterone can be decreased when it is combined with Nafcillin.Approved
NorgestrelThe serum concentration of Norgestrel can be decreased when it is combined with Nafcillin.Approved
NortriptylineThe serum concentration of Nortriptyline can be decreased when it is combined with Nafcillin.Approved
OlaparibThe serum concentration of Olaparib can be decreased when it is combined with Nafcillin.Approved
OlopatadineThe serum concentration of Olopatadine can be decreased when it is combined with Nafcillin.Approved
OmeprazoleThe serum concentration of Omeprazole can be decreased when it is combined with Nafcillin.Approved, Investigational, Vet Approved
OndansetronThe serum concentration of Ondansetron can be decreased when it is combined with Nafcillin.Approved
OrphenadrineThe serum concentration of Orphenadrine can be decreased when it is combined with Nafcillin.Approved
OspemifeneThe serum concentration of Ospemifene can be decreased when it is combined with Nafcillin.Approved
OxazepamThe serum concentration of Oxazepam can be decreased when it is combined with Nafcillin.Approved
OxybutyninThe serum concentration of Oxybutynin can be decreased when it is combined with Nafcillin.Approved, Investigational
OxycodoneThe serum concentration of Oxycodone can be decreased when it is combined with Nafcillin.Approved, Illicit, Investigational
OxymorphoneThe serum concentration of Oxymorphone can be decreased when it is combined with Nafcillin.Approved, Investigational, Vet Approved
OxytetracyclineThe therapeutic efficacy of Nafcillin can be decreased when used in combination with Oxytetracycline.Approved, Vet Approved
PaclitaxelThe serum concentration of Paclitaxel can be decreased when it is combined with Nafcillin.Approved, Vet Approved
PalbociclibThe serum concentration of Palbociclib can be decreased when it is combined with Nafcillin.Approved
PalonosetronThe serum concentration of Palonosetron can be decreased when it is combined with Nafcillin.Approved, Investigational
PanobinostatThe serum concentration of Panobinostat can be decreased when it is combined with Nafcillin.Approved, Investigational
PantoprazoleThe serum concentration of Pantoprazole can be decreased when it is combined with Nafcillin.Approved
ParamethadioneThe serum concentration of Paramethadione can be decreased when it is combined with Nafcillin.Approved
ParamethasoneThe serum concentration of Paramethasone can be decreased when it is combined with Nafcillin.Approved
ParecoxibThe serum concentration of Parecoxib can be decreased when it is combined with Nafcillin.Approved
ParicalcitolThe serum concentration of Paricalcitol can be decreased when it is combined with Nafcillin.Approved, Investigational
ParitaprevirThe serum concentration of Paritaprevir can be decreased when it is combined with Nafcillin.Approved
ParomomycinThe serum concentration of Paromomycin can be decreased when it is combined with Nafcillin.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be decreased when it is combined with Nafcillin.Approved
PentamidineThe serum concentration of Pentamidine can be decreased when it is combined with Nafcillin.Approved
PerampanelThe serum concentration of Perampanel can be decreased when it is combined with Nafcillin.Approved
PergolideThe serum concentration of Pergolide can be decreased when it is combined with Nafcillin.Approved, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be increased when combined with Nafcillin.Approved
PermethrinThe serum concentration of Permethrin can be decreased when it is combined with Nafcillin.Approved, Investigational
PerphenazineThe serum concentration of Perphenazine can be decreased when it is combined with Nafcillin.Approved
PethidineThe serum concentration of Pethidine can be decreased when it is combined with Nafcillin.Approved
PhenacetinThe serum concentration of Phenacetin can be decreased when it is combined with Nafcillin.Withdrawn
PhenindioneNafcillin may decrease the anticoagulant activities of Phenindione.Approved
PhenoxybenzamineThe serum concentration of Phenoxybenzamine can be decreased when it is combined with Nafcillin.Approved
PhenprocoumonNafcillin may decrease the anticoagulant activities of Phenprocoumon.Approved
PhenytoinThe serum concentration of Phenytoin can be decreased when it is combined with Nafcillin.Approved, Vet Approved
Picosulfuric acidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Nafcillin.Approved
PilocarpineThe serum concentration of Pilocarpine can be decreased when it is combined with Nafcillin.Approved
PimecrolimusThe serum concentration of Pimecrolimus can be decreased when it is combined with Nafcillin.Approved, Investigational
PimozideThe serum concentration of Pimozide can be decreased when it is combined with Nafcillin.Approved
PinacidilThe serum concentration of Pinacidil can be decreased when it is combined with Nafcillin.Withdrawn
PinaveriumThe metabolism of Pinaverium can be increased when combined with Nafcillin.Approved
PioglitazoneThe serum concentration of Pioglitazone can be decreased when it is combined with Nafcillin.Approved, Investigational
PipotiazineThe serum concentration of Pipotiazine can be decreased when it is combined with Nafcillin.Approved
PirarubicinThe serum concentration of Pirarubicin can be decreased when it is combined with Nafcillin.Investigational
PlicamycinThe serum concentration of Plicamycin can be decreased when it is combined with Nafcillin.Approved, Withdrawn
PodofiloxThe serum concentration of Podofilox can be decreased when it is combined with Nafcillin.Approved
PomalidomideThe serum concentration of Pomalidomide can be decreased when it is combined with Nafcillin.Approved
PonatinibThe serum concentration of Ponatinib can be decreased when it is combined with Nafcillin.Approved
PosaconazoleThe serum concentration of Posaconazole can be decreased when it is combined with Nafcillin.Approved, Investigational, Vet Approved
PrasteroneThe serum concentration of Prasterone can be decreased when it is combined with Nafcillin.Approved, Nutraceutical
PrasugrelThe serum concentration of Prasugrel can be decreased when it is combined with Nafcillin.Approved
PravastatinThe serum concentration of Pravastatin can be decreased when it is combined with Nafcillin.Approved
PrazepamThe serum concentration of Prazepam can be decreased when it is combined with Nafcillin.Approved, Illicit
PraziquantelThe serum concentration of Praziquantel can be decreased when it is combined with Nafcillin.Approved, Vet Approved
PrednisoloneThe serum concentration of Prednisolone can be decreased when it is combined with Nafcillin.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be decreased when it is combined with Nafcillin.Approved, Vet Approved
PregabalinThe metabolism of Pregabalin can be increased when combined with Nafcillin.Approved, Illicit, Investigational
PrenylamineThe metabolism of Prenylamine can be increased when combined with Nafcillin.Withdrawn
PrimaquineThe serum concentration of Primaquine can be decreased when it is combined with Nafcillin.Approved
ProbenecidThe serum concentration of Nafcillin can be increased when it is combined with Probenecid.Approved
ProchlorperazineThe serum concentration of Prochlorperazine can be decreased when it is combined with Nafcillin.Approved, Vet Approved
ProgesteroneThe serum concentration of Progesterone can be decreased when it is combined with Nafcillin.Approved, Vet Approved
ProguanilThe serum concentration of Proguanil can be decreased when it is combined with Nafcillin.Approved
PromazineThe serum concentration of Promazine can be decreased when it is combined with Nafcillin.Approved, Vet Approved
PropafenoneThe serum concentration of Propafenone can be decreased when it is combined with Nafcillin.Approved
PropofolThe serum concentration of Propofol can be decreased when it is combined with Nafcillin.Approved, Investigational, Vet Approved
PropranololThe serum concentration of Propranolol can be decreased when it is combined with Nafcillin.Approved, Investigational
PuromycinThe serum concentration of Puromycin can be decreased when it is combined with Nafcillin.Experimental
PyrazinamideThe serum concentration of Pyrazinamide can be decreased when it is combined with Nafcillin.Approved
QuazepamThe serum concentration of Quazepam can be decreased when it is combined with Nafcillin.Approved, Illicit
QuetiapineThe serum concentration of Quetiapine can be decreased when it is combined with Nafcillin.Approved
QuinacrineThe serum concentration of Quinacrine can be decreased when it is combined with Nafcillin.Approved
QuinidineThe serum concentration of Quinidine can be decreased when it is combined with Nafcillin.Approved
QuinineThe serum concentration of Quinine can be decreased when it is combined with Nafcillin.Approved
RabeprazoleThe serum concentration of Rabeprazole can be decreased when it is combined with Nafcillin.Approved, Investigational
RaloxifeneThe serum concentration of Raloxifene can be decreased when it is combined with Nafcillin.Approved, Investigational
RamelteonThe serum concentration of Ramelteon can be decreased when it is combined with Nafcillin.Approved, Investigational
RanolazineThe serum concentration of Ranolazine can be decreased when it is combined with Nafcillin.Approved, Investigational
ReboxetineThe serum concentration of Reboxetine can be decreased when it is combined with Nafcillin.Approved, Investigational
RegorafenibThe serum concentration of Regorafenib can be decreased when it is combined with Nafcillin.Approved
RepaglinideThe serum concentration of Repaglinide can be decreased when it is combined with Nafcillin.Approved, Investigational
RetapamulinThe serum concentration of Retapamulin can be decreased when it is combined with Nafcillin.Approved
RibostamycinThe serum concentration of Ribostamycin can be decreased when it is combined with Nafcillin.Approved
RifabutinThe serum concentration of Rifabutin can be decreased when it is combined with Nafcillin.Approved
RifampicinThe serum concentration of Rifampicin can be decreased when it is combined with Nafcillin.Approved
RilpivirineThe serum concentration of Rilpivirine can be decreased when it is combined with Nafcillin.Approved
RimonabantThe serum concentration of Rimonabant can be decreased when it is combined with Nafcillin.Approved, Investigational
RiociguatThe serum concentration of Riociguat can be decreased when it is combined with Nafcillin.Approved
RisedronateThe metabolism of Risedronate can be increased when combined with Nafcillin.Approved, Investigational
RisperidoneThe serum concentration of Risperidone can be decreased when it is combined with Nafcillin.Approved, Investigational
RitonavirThe serum concentration of Ritonavir can be decreased when it is combined with Nafcillin.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be decreased when it is combined with Nafcillin.Approved
RofecoxibThe serum concentration of Rofecoxib can be decreased when it is combined with Nafcillin.Investigational, Withdrawn
RolapitantThe serum concentration of Rolapitant can be decreased when it is combined with Nafcillin.Approved
RomidepsinThe serum concentration of Romidepsin can be decreased when it is combined with Nafcillin.Approved, Investigational
RopiniroleThe serum concentration of Ropinirole can be decreased when it is combined with Nafcillin.Approved, Investigational
RopivacaineThe serum concentration of Ropivacaine can be decreased when it is combined with Nafcillin.Approved
RosuvastatinThe serum concentration of Rosuvastatin can be decreased when it is combined with Nafcillin.Approved
RotigotineThe serum concentration of Rotigotine can be decreased when it is combined with Nafcillin.Approved
RoxithromycinThe serum concentration of Roxithromycin can be decreased when it is combined with Nafcillin.Approved, Withdrawn
RuxolitinibThe serum concentration of Ruxolitinib can be decreased when it is combined with Nafcillin.Approved
SalmeterolThe serum concentration of Salmeterol can be decreased when it is combined with Nafcillin.Approved
SaquinavirThe serum concentration of Saquinavir can be decreased when it is combined with Nafcillin.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Nafcillin.Approved
SelegilineThe serum concentration of Selegiline can be decreased when it is combined with Nafcillin.Approved, Investigational, Vet Approved
SelexipagThe serum concentration of Selexipag can be decreased when it is combined with Nafcillin.Approved
SeratrodastThe serum concentration of Seratrodast can be decreased when it is combined with Nafcillin.Approved, Investigational
SertindoleThe serum concentration of Sertindole can be decreased when it is combined with Nafcillin.Approved, Withdrawn
SertralineThe serum concentration of Sertraline can be decreased when it is combined with Nafcillin.Approved
SevofluraneThe serum concentration of Sevoflurane can be decreased when it is combined with Nafcillin.Approved, Vet Approved
SibutramineThe serum concentration of Sibutramine can be decreased when it is combined with Nafcillin.Approved, Illicit, Investigational, Withdrawn
SildenafilThe serum concentration of Sildenafil can be decreased when it is combined with Nafcillin.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be decreased when it is combined with Nafcillin.Approved
SimeprevirThe serum concentration of Simeprevir can be decreased when it is combined with Nafcillin.Approved
SimvastatinThe serum concentration of Simvastatin can be decreased when it is combined with Nafcillin.Approved
SirolimusThe serum concentration of Sirolimus can be decreased when it is combined with Nafcillin.Approved, Investigational
SisomicinThe serum concentration of Sisomicin can be decreased when it is combined with Nafcillin.Investigational
SitagliptinThe serum concentration of Sitagliptin can be decreased when it is combined with Nafcillin.Approved, Investigational
SolifenacinThe serum concentration of Solifenacin can be decreased when it is combined with Nafcillin.Approved
SonidegibThe serum concentration of Sonidegib can be decreased when it is combined with Nafcillin.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be decreased when it is combined with Nafcillin.Approved, Investigational
SP1049CThe serum concentration of SP1049C can be decreased when it is combined with Nafcillin.Investigational
SpectinomycinThe serum concentration of Spectinomycin can be decreased when it is combined with Nafcillin.Approved, Vet Approved
SpiramycinThe serum concentration of Spiramycin can be decreased when it is combined with Nafcillin.Approved
StreptomycinThe serum concentration of Streptomycin can be decreased when it is combined with Nafcillin.Approved, Vet Approved
StreptozocinThe serum concentration of Streptozocin can be decreased when it is combined with Nafcillin.Approved
SufentanilThe serum concentration of Sufentanil can be decreased when it is combined with Nafcillin.Approved, Investigational
SulfadiazineThe serum concentration of Sulfadiazine can be decreased when it is combined with Nafcillin.Approved, Vet Approved
SulfamethoxazoleThe serum concentration of Sulfamethoxazole can be decreased when it is combined with Nafcillin.Approved
SulfinpyrazoneThe serum concentration of Sulfinpyrazone can be decreased when it is combined with Nafcillin.Approved
SunitinibThe serum concentration of Sunitinib can be decreased when it is combined with Nafcillin.Approved, Investigational
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be increased when combined with Nafcillin.Approved
Synthetic Conjugated Estrogens, BThe serum concentration of Synthetic Conjugated Estrogens, B can be decreased when it is combined with Nafcillin.Approved
TacrolimusThe serum concentration of Tacrolimus can be decreased when it is combined with Nafcillin.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be decreased when it is combined with Nafcillin.Approved, Investigational
TamoxifenThe serum concentration of Tamoxifen can be decreased when it is combined with Nafcillin.Approved
TamsulosinThe serum concentration of Tamsulosin can be decreased when it is combined with Nafcillin.Approved, Investigational
TasosartanThe serum concentration of Tasosartan can be decreased when it is combined with Nafcillin.Approved
Taurochenodeoxycholic acidThe serum concentration of Taurochenodeoxycholic acid can be decreased when it is combined with Nafcillin.Experimental
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Nafcillin.Approved
TelithromycinThe serum concentration of Telithromycin can be decreased when it is combined with Nafcillin.Approved
TemazepamThe serum concentration of Temazepam can be decreased when it is combined with Nafcillin.Approved
TemsirolimusThe serum concentration of Temsirolimus can be decreased when it is combined with Nafcillin.Approved
TeniposideThe serum concentration of Teniposide can be decreased when it is combined with Nafcillin.Approved
TerbinafineThe serum concentration of Terbinafine can be decreased when it is combined with Nafcillin.Approved, Investigational, Vet Approved
TerfenadineThe serum concentration of Terfenadine can be decreased when it is combined with Nafcillin.Withdrawn
TesmilifeneThe serum concentration of Tesmilifene can be decreased when it is combined with Nafcillin.Investigational
TestosteroneThe serum concentration of Testosterone can be decreased when it is combined with Nafcillin.Approved, Investigational
TetracyclineThe therapeutic efficacy of Nafcillin can be decreased when used in combination with Tetracycline.Approved, Vet Approved
TheophyllineThe serum concentration of Theophylline can be decreased when it is combined with Nafcillin.Approved
ThiotepaThe serum concentration of Thiotepa can be decreased when it is combined with Nafcillin.Approved
TiagabineThe serum concentration of Tiagabine can be decreased when it is combined with Nafcillin.Approved
TicagrelorThe serum concentration of Ticagrelor can be decreased when it is combined with Nafcillin.Approved
TiclopidineThe serum concentration of Ticlopidine can be decreased when it is combined with Nafcillin.Approved
TinidazoleThe serum concentration of Tinidazole can be decreased when it is combined with Nafcillin.Approved, Investigational
TiotropiumThe serum concentration of Tiotropium can be decreased when it is combined with Nafcillin.Approved
TipranavirThe serum concentration of Tipranavir can be decreased when it is combined with Nafcillin.Approved, Investigational
TobramycinThe serum concentration of Tobramycin can be decreased when it is combined with Nafcillin.Approved, Investigational
TofacitinibThe serum concentration of Tofacitinib can be decreased when it is combined with Nafcillin.Approved, Investigational
Tolfenamic AcidThe metabolism of Tolfenamic Acid can be increased when combined with Nafcillin.Approved
TolterodineThe serum concentration of Tolterodine can be decreased when it is combined with Nafcillin.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be decreased when it is combined with Nafcillin.Approved
ToremifeneThe serum concentration of Toremifene can be decreased when it is combined with Nafcillin.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be decreased when it is combined with Nafcillin.Approved, Investigational
TramadolThe serum concentration of Tramadol can be decreased when it is combined with Nafcillin.Approved, Investigational
TranilastThe metabolism of Tranilast can be increased when combined with Nafcillin.Approved, Investigational
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be decreased when it is combined with Nafcillin.Approved
TrazodoneThe serum concentration of Trazodone can be decreased when it is combined with Nafcillin.Approved, Investigational
TretinoinThe serum concentration of Tretinoin can be decreased when it is combined with Nafcillin.Approved, Investigational, Nutraceutical
TriamcinoloneThe serum concentration of Triamcinolone can be decreased when it is combined with Nafcillin.Approved, Vet Approved
TriazolamThe serum concentration of Triazolam can be decreased when it is combined with Nafcillin.Approved
TrimethadioneThe serum concentration of Trimethadione can be decreased when it is combined with Nafcillin.Approved
TrimethoprimThe serum concentration of Trimethoprim can be decreased when it is combined with Nafcillin.Approved, Vet Approved
TrimipramineThe serum concentration of Trimipramine can be decreased when it is combined with Nafcillin.Approved
TroglitazoneThe serum concentration of Troglitazone can be decreased when it is combined with Nafcillin.Withdrawn
TroleandomycinThe serum concentration of Troleandomycin can be decreased when it is combined with Nafcillin.Approved
UdenafilThe serum concentration of Udenafil can be decreased when it is combined with Nafcillin.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be decreased when it is combined with Nafcillin.Approved
ValdecoxibThe serum concentration of Valdecoxib can be decreased when it is combined with Nafcillin.Investigational, Withdrawn
ValrubicinThe serum concentration of Valrubicin can be decreased when it is combined with Nafcillin.Approved
VandetanibThe serum concentration of Vandetanib can be decreased when it is combined with Nafcillin.Approved
VanoxerineThe serum concentration of Vanoxerine can be decreased when it is combined with Nafcillin.Investigational
VardenafilThe serum concentration of Vardenafil can be decreased when it is combined with Nafcillin.Approved
VemurafenibThe serum concentration of Vemurafenib can be decreased when it is combined with Nafcillin.Approved
VenetoclaxThe serum concentration of Venetoclax can be decreased when it is combined with Nafcillin.Approved
VenlafaxineThe serum concentration of Venlafaxine can be decreased when it is combined with Nafcillin.Approved
VerapamilThe metabolism of Verapamil can be increased when combined with Nafcillin.Approved
VicrivirocThe serum concentration of Vicriviroc can be decreased when it is combined with Nafcillin.Investigational
VilanterolThe serum concentration of Vilanterol can be decreased when it is combined with Nafcillin.Approved
VilazodoneThe serum concentration of Vilazodone can be decreased when it is combined with Nafcillin.Approved
VinblastineThe serum concentration of Vinblastine can be decreased when it is combined with Nafcillin.Approved
VincristineThe serum concentration of Vincristine can be decreased when it is combined with Nafcillin.Approved, Investigational
VindesineThe serum concentration of Vindesine can be decreased when it is combined with Nafcillin.Approved
VinorelbineThe serum concentration of Vinorelbine can be decreased when it is combined with Nafcillin.Approved, Investigational
VinpocetineThe metabolism of Vinpocetine can be increased when combined with Nafcillin.Investigational
VismodegibThe serum concentration of Vismodegib can be decreased when it is combined with Nafcillin.Approved
VoriconazoleThe serum concentration of Voriconazole can be decreased when it is combined with Nafcillin.Approved, Investigational
VortioxetineThe serum concentration of Vortioxetine can be decreased when it is combined with Nafcillin.Approved
WarfarinNafcillin may decrease the anticoagulant activities of Warfarin.Approved
XylometazolineThe metabolism of Xylometazoline can be increased when combined with Nafcillin.Approved
YohimbineThe serum concentration of Yohimbine can be decreased when it is combined with Nafcillin.Approved, Vet Approved
ZafirlukastThe serum concentration of Zafirlukast can be decreased when it is combined with Nafcillin.Approved, Investigational
ZalcitabineThe serum concentration of Zalcitabine can be decreased when it is combined with Nafcillin.Approved
ZaleplonThe serum concentration of Zaleplon can be decreased when it is combined with Nafcillin.Approved, Illicit, Investigational
ZiconotideThe metabolism of Ziconotide can be increased when combined with Nafcillin.Approved
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Nafcillin.Approved
ZileutonThe serum concentration of Zileuton can be decreased when it is combined with Nafcillin.Approved, Investigational, Withdrawn
ZiprasidoneThe serum concentration of Ziprasidone can be decreased when it is combined with Nafcillin.Approved
ZolpidemThe serum concentration of Zolpidem can be decreased when it is combined with Nafcillin.Approved
ZomepiracThe serum concentration of Zomepirac can be decreased when it is combined with Nafcillin.Withdrawn
ZonisamideThe serum concentration of Zonisamide can be decreased when it is combined with Nafcillin.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be decreased when it is combined with Nafcillin.Approved
ZorubicinThe serum concentration of Zorubicin can be decreased when it is combined with Nafcillin.Experimental
Food InteractionsNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesJ01CF06
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (44.1 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption-0.5328
Blood Brain Barrier-0.9938
Caco-2 permeable-0.6248
P-glycoprotein substrateSubstrate0.708
P-glycoprotein inhibitor INon-inhibitor0.8782
P-glycoprotein inhibitor IINon-inhibitor0.8807
Renal organic cation transporterNon-inhibitor0.923
CYP450 2C9 substrateNon-substrate0.7898
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateNon-substrate0.5
CYP450 1A2 substrateNon-inhibitor0.8164
CYP450 2C9 inhibitorNon-inhibitor0.7263
CYP450 2D6 inhibitorNon-inhibitor0.8869
CYP450 2C19 inhibitorNon-inhibitor0.8082
CYP450 3A4 inhibitorInhibitor0.5653
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7437
Ames testNon AMES toxic0.796
CarcinogenicityNon-carcinogens0.6679
BiodegradationNot ready biodegradable0.9972
Rat acute toxicity2.1208 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9994
hERG inhibition (predictor II)Non-inhibitor0.6449
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Wyeth ayerst laboratories
  • Apothecon inc div bristol myers squibb
  • Marsam pharmaceuticals llc
  • Sandoz inc
  • Glaxosmithkline
  • Baxter healthcare corp
Packagers
Dosage forms
FormRouteStrength
InjectionIntramuscular; Intravenous1 g/1
InjectionIntramuscular; Intravenous2 g/1
Injection, powder, for solutionIntramuscular; Intravenous1 g/1
Injection, powder, for solutionIntramuscular; Intravenous2 g/1
Injection, powder, for solutionIntravenous10 g/100mL
Injection, solutionIntravenous1 g/50mL
Injection, solutionIntravenous2 g/100mL
Powder, for solutionIntramuscular; Intravenous1 g/4mL
Powder, for solutionIntramuscular; Intravenous1 g/1
Powder, for solutionIntramuscular; Intravenous2 g/8mL
Powder, for solutionIntramuscular; Intravenous2 g/1
Injection, powder, for solutionIntramuscular; Intravenous1 g/4mL
Injection, powder, for solutionIntramuscular; Intravenous2 g/8mL
Injection, powder, for solutionIntravenous1 g/1
Injection, powder, for solutionIntravenous2 g/1
Powder, for solutionIntramuscular; Intravenous500 mg
Prices
Unit descriptionCostUnit
Nafcillin 10 gm vial118.01USD vial
Nafcillin 2 gm vial24.08USD vial
Nafcillin 1 gm vial12.41USD vial
Nafcillin 1 gm/ 50 ml inj0.43USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
water solubilitySolubleNot Available
logP3.3Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0172 mg/mLALOGPS
logP3.21ALOGPS
logP2.29ChemAxon
logS-4.4ALOGPS
pKa (Strongest Acidic)3.31ChemAxon
pKa (Strongest Basic)-1.6ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area95.94 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity108.14 m3·mol-1ChemAxon
Polarizability42.22 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as penicillins. These are organic compounds containing the penicillin core structure, which is structurally characterized by a penam ring bearing two methyl groups at position 2, and an amide group at position 6 [starting from the sulfur atom at position 1].
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassLactams
Sub ClassBeta lactams
Direct ParentPenicillins
Alternative Parents
Substituents
  • Penicillin
  • 1-naphthalenecarboxylic acid or derivatives
  • 1-naphthalenecarboxamide
  • N-acyl-alpha amino acid or derivatives
  • Naphthalene
  • Alpha-amino acid or derivatives
  • Benzamide
  • Benzoyl
  • Alkyl aryl ether
  • Benzenoid
  • Thiazolidine
  • Tertiary carboxylic acid amide
  • Tertiary amine
  • Secondary carboxylic acid amide
  • Carboxamide group
  • Azetidine
  • Azacycle
  • Dialkylthioether
  • Hemithioaminal
  • Thioether
  • Monocarboxylic acid or derivatives
  • Ether
  • Carboxylic acid
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Pharmacological action
yes
Actions
inhibitor
General Function:
Transferase activity, transferring acyl groups
Specific Function:
Not Available
Gene Name:
pbp1b
Uniprot ID:
Q7CRA4
Molecular Weight:
89479.92 Da
References
  1. Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. [PubMed:7447421 ]
Kind
Protein
Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Pharmacological action
yes
Actions
inhibitor
General Function:
Penicillin binding
Specific Function:
Not Available
Gene Name:
penA
Uniprot ID:
P0A3M6
Molecular Weight:
73872.305 Da
References
  1. Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. [PubMed:7447421 ]
Kind
Protein
Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Pharmacological action
yes
Actions
inhibitor
General Function:
Transferase activity, transferring acyl groups
Specific Function:
Not Available
Gene Name:
pbp2a
Uniprot ID:
Q8DNB6
Molecular Weight:
80797.94 Da
References
  1. Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. [PubMed:7447421 ]
Kind
Protein
Organism
Streptococcus pneumoniae
Pharmacological action
yes
Actions
inhibitor
General Function:
Serine-type d-ala-d-ala carboxypeptidase activity
Specific Function:
Not Available
Gene Name:
pbp3
Uniprot ID:
Q75Y35
Molecular Weight:
45209.84 Da
References
  1. Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. [PubMed:7447421 ]
Kind
Protein
Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Pharmacological action
yes
Actions
inhibitor
General Function:
Penicillin binding
Specific Function:
Cell wall formation.
Gene Name:
pbpA
Uniprot ID:
Q8DR59
Molecular Weight:
79700.9 Da
References
  1. Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. [PubMed:7447421 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Yasuda K, Ranade A, Venkataramanan R, Strom S, Chupka J, Ekins S, Schuetz E, Bachmann K: A comprehensive in vitro and in silico analysis of antibiotics that activate pregnane X receptor and induce CYP3A4 in liver and intestine. Drug Metab Dispos. 2008 Aug;36(8):1689-97. doi: 10.1124/dmd.108.020701. Epub 2008 May 27. [PubMed:18505790 ]
  2. Kim KY, Frey RJ, Epplen K, Foruhari F: Interaction between warfarin and nafcillin: case report and review of the literature. Pharmacotherapy. 2007 Oct;27(10):1467-70. [PubMed:17896903 ]
  3. Lang CC, Jamal SK, Mohamed Z, Mustafa MR, Mustafa AM, Lee TC: Evidence of an interaction between nifedipine and nafcillin in humans. Br J Clin Pharmacol. 2003 Jun;55(6):588-90. [PubMed:12814453 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-in...
Gene Name:
SLC22A6
Uniprot ID:
Q4U2R8
Molecular Weight:
61815.78 Da
References
  1. Jariyawat S, Sekine T, Takeda M, Apiwattanakul N, Kanai Y, Sophasan S, Endou H: The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. J Pharmacol Exp Ther. 1999 Aug;290(2):672-7. [PubMed:10411577 ]
Comments
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23