Antitussive Agents

Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally.
DrugDrug NameDrug Description
DB00318CodeineAn opioid analgesic used to treat moderate to severe pain when the use of an opioid is indicated.
DB00514DextromethorphanAn NMDA receptor antagonist used to treat cases of dry cough.
DB00956HydrocodoneAn opioid agonist used as an analgesic and antitussive agent.
DB00333MethadoneAn opioid analgesic indicated for management of severe pain that is not responsive to alternative treatments. Also used to aid in detoxification and maintenance treatment of opioid addiction.
DB00611ButorphanolAn opioid agonist-antagonist used to treat moderate to severe pain.
DB00868BenzonatateA non-narcotic oral antitussive drug used to suppress coughing.
DB01466EthylmorphineEthylmorphine is an analgesic used for pain relief.
DB04822OxeladinWithdrawn from the Canadian, US, and UK markets in 1976 due to carcinogenicity.
DB06174NoscapineInvestigated for use/treatment in lymphoma (non-hodgkin's), leukemia (lymphoid), cancer/tumors (unspecified), and multiple myeloma.
DB08796PipazethateFor the treatment of cough.
DB08944IsoaminileIsoaminile, an antitussive drug with a structure similar to methadone, is also an anticholinergic with both antimuscarinic and antinicotinic properties.
DB08968FominobenFominoben is an antitussive agent.
DB09004ClobutinolClobutinol is a cough suppressant that is withdrawn from the US and EU markets. Clobutinol may prolong the QT interval. In 2007, Clobutinol was determined to cause cardiac arrhythmia in...
DB09209PholcodinePholcodine is indicated as a cough suppressant for the temporary relief of non-productive dry cough. It is stated to present a required label indication of "temporary relief of dry cough."...
DB09273DoxofyllineIndicated for the treatment of chronic obstructive pulmonary disease (COPD), bronchial asthma and pulmonary disease with spastic bronchial component.
DB11130OpiumA medication used to treat moderate to severe pain.
DB11186PentoxyverineA medication used to suppress a cough in the common cold, flu, bronchitis, and sinusitis.
DB11609NormethadoneAn opioid antitussive used to treat a cough associated with inflamed mucosa.
DB12472LevodropropizineLevodropropizine is under investigation in clinical trial NCT01573663 (A Drug-Drug Interaction Study of Ambroxol and Levodropropizine).
DB13216OxolamineOxolamine is not approved in the USA, it may be marketed elsewhere internationally as a cough suppressant . It is listed as a prescription drug in New Zealand legislation ....
DB13538GuacetisalNot Annotated
DB13564ZipeprolNot Annotated
DB13785DropropizineNot Annotated
DB13810DimemorfanNot Annotated
DB04837ClofedanolAn antitussive used for the symptomatic relief of acute cough caused by minor throat and bronchial irritation.
DB03852EucalyptolA common ingredient in mouthwash and cosmetics derived naturally from the eucalyptus plant that is frequently used to to improve symptoms of airway mucus hypersecretion.
DB06793LevopropoxypheneLevopropoxyphene was used as an antitussive. An antitussive is a medication often recommended for the treatment of cough and associated respiratory tract disorders. Its enantiomer, dextropropoxyphene, presents an analgesic effect.
DrugDrug NameTargetType
DB00318CodeineMu-type opioid receptortarget
DB00318CodeineDelta-type opioid receptortarget
DB00318CodeineKappa-type opioid receptortarget
DB00318CodeineCytochrome P450 2D6enzyme
DB00318CodeineCytochrome P450 3A4enzyme
DB00318CodeineSolute carrier family 22 member 1transporter
DB00318CodeineUDP-glucuronosyltransferase 2B7enzyme
DB00318CodeineUDP-glucuronosyltransferase 2B4enzyme
DB00514DextromethorphanSigma non-opioid intracellular receptor 1target
DB00514DextromethorphanHCG20471, isoform CRA_ctarget
DB00514DextromethorphanNeuronal acetylcholine receptor subunit alpha-2target
DB00514DextromethorphanSodium-dependent serotonin transportertarget
DB00514DextromethorphanGlutamate receptor ionotropic, NMDA 3Atarget
DB00514DextromethorphanCytochrome P450 2D6enzyme
DB00514DextromethorphanCytochrome P450 3A4enzyme
DB00514DextromethorphanCytochrome P450 3A7enzyme
DB00514DextromethorphanCytochrome P450 2C9enzyme
DB00514DextromethorphanCytochrome P450 2B6enzyme
DB00514DextromethorphanCytochrome P450 2C19enzyme
DB00514DextromethorphanMembrane-associated progesterone receptor component 1target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit alpha-3target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit alpha-4target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit beta-4target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit beta-2target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit alpha-7target
DB00514DextromethorphanMu-type opioid receptortarget
DB00514DextromethorphanDelta-type opioid receptortarget
DB00514DextromethorphanKappa-type opioid receptortarget
DB00514DextromethorphanNADPH oxidasetarget
DB00514DextromethorphanSodium-dependent noradrenaline transportertarget
DB00956HydrocodoneMu-type opioid receptortarget
DB00956HydrocodoneDelta-type opioid receptortarget
DB00956HydrocodoneCytochrome P450 3A4enzyme
DB00956HydrocodoneCytochrome P450 2D6enzyme
DB00956HydrocodoneCytochrome P450 2B6enzyme
DB00956HydrocodoneCytochrome P450 2C19enzyme
DB00956HydrocodoneSigma non-opioid intracellular receptor 1target
DB00333MethadoneNMDA receptortarget
DB00333MethadoneMu-type opioid receptortarget
DB00333MethadoneCytochrome P450 2B6enzyme
DB00333MethadoneCytochrome P450 3A4enzyme
DB00333MethadoneCytochrome P450 2C19enzyme
DB00333MethadoneDelta-type opioid receptortarget
DB00333MethadoneCytochrome P450 3A7enzyme
DB00333MethadoneCytochrome P450 2D6enzyme
DB00333MethadoneP-glycoprotein 1transporter
DB00333MethadoneCytochrome P450 2C8enzyme
DB00333MethadoneCytochrome P450 19A1enzyme
DB00333MethadoneCytochrome P450 1A2enzyme
DB00333MethadoneCytochrome P450 2C18enzyme
DB00333MethadoneCytochrome P450 2C9enzyme
DB00333Methadone5-hydroxytryptamine receptor 3Atarget
DB00333MethadoneAlpha-1-acid glycoprotein 1carrier
DB00333MethadoneSerum albumincarrier
DB00333MethadoneNeuronal acetylcholine receptor subunit alpha-7target
DB00333MethadoneNeuronal acetylcholine receptor subunit alpha-3target
DB00333MethadoneNeuronal acetylcholine receptor subunit alpha-4target
DB00333MethadoneNeuronal acetylcholine receptor subunit beta-2target
DB00611ButorphanolKappa-type opioid receptortarget
DB00611ButorphanolMu-type opioid receptortarget
DB00611ButorphanolDelta-type opioid receptortarget
DB00868BenzonatateSodium channel protein type 5 subunit alphatarget
DB00868BenzonatateCholinesteraseenzyme
DB01466EthylmorphineCytochrome P450 2D6enzyme
DB01466EthylmorphineNADPH--cytochrome P450 reductaseenzyme
DB01466EthylmorphineMu-type opioid receptortarget
DB01466EthylmorphineCytochrome P450 2B6enzyme
DB01466EthylmorphineCytochrome P450 3A4enzyme
DB06174NoscapineSigma non-opioid intracellular receptor 1target
DB06174NoscapineCytochrome P450 2C9enzyme
DB06174NoscapineCytochrome P450 3A4enzyme
DB09209PholcodineMu-type opioid receptortarget
DB09209PholcodineKappa-type opioid receptortarget
DB09209PholcodineDelta-type opioid receptortarget
DB09273DoxofyllinePhosphodiesterase 2A, cGMP-stimulatedtarget
DB09273DoxofyllineAdenosine receptor A2atarget
DB09273DoxofyllineBeta-2 adrenergic receptortarget
DB09273DoxofyllineCytochrome P450 1A2enzyme
DB11130OpiumDelta-type opioid receptortarget
DB11130OpiumKappa-type opioid receptortarget
DB11130OpiumMu-type opioid receptortarget
DB11130OpiumSerum albumincarrier
DB11130OpiumBeta-2-microglobulincarrier
DB11130OpiumCytochrome P450 2D6enzyme
DB11130OpiumCytochrome P450 3A4enzyme
DB11186PentoxyverineSigma non-opioid intracellular receptor 1target
DB11186PentoxyverinePotassium voltage-gated channel subfamily H member 2target
DB11186PentoxyverineVoltage-gated sodium channel alpha subunittarget
DB11186PentoxyverineKappa-type opioid receptortarget
DB11186PentoxyverineMu-type opioid receptortarget
DB04837ClofedanolHistamine H1 receptortarget