Antitussive Agents

Antitussive Agents
Accession Number

Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally.

DrugDrug Description
CodeineAn opioid analgesic used to treat moderate to severe pain when the use of an opioid is indicated.
DextromethorphanAn NMDA receptor antagonist used to treat cases of dry cough.
HydrocodoneAn opioid agonist used as an analgesic and antitussive agent.
MethadoneAn opioid analgesic indicated for management of severe pain that is not responsive to alternative treatments. Also used to aid in detoxification and maintenance treatment of opioid addiction.
ButorphanolAn opioid agonist-antagonist used to treat moderate to severe pain.
BenzonatateA non-narcotic oral antitussive drug used to suppress coughing.
EthylmorphineEthylmorphine is an analgesic used for pain relief.
OxeladinWithdrawn from the Canadian, US, and UK markets in 1976 due to carcinogenicity.
NoscapineInvestigated for use/treatment in lymphoma (non-hodgkin's), leukemia (lymphoid), cancer/tumors (unspecified), and multiple myeloma.
PipazethateFor the treatment of cough.
IsoaminileIsoaminile, an antitussive drug with a structure similar to methadone, is also an anticholinergic with both antimuscarinic and antinicotinic properties.
FominobenFominoben is an antitussive agent.
ClobutinolClobutinol is a cough suppressant that is withdrawn from the US and EU markets. Clobutinol may prolong the QT interval. In 2007, Clobutinol was determined to cause cardiac arrhythmia in...
PholcodinePholcodine is indicated as a cough suppressant for the temporary relief of non-productive dry cough. It is stated to present a required label indication of "temporary relief of dry cough."...
DoxofyllineIndicated for the treatment of chronic obstructive pulmonary disease (COPD), bronchial asthma and pulmonary disease with spastic bronchial component.
OpiumA medication used to treat moderate to severe pain.
PentoxyverineA medication used to suppress a cough in the common cold, flu, bronchitis, and sinusitis.
NormethadoneAn opioid antitussive used to treat a cough associated with inflamed mucosa.
LevodropropizineLevodropropizine is under investigation in clinical trial NCT01573663 (A Drug-Drug Interaction Study of Ambroxol and Levodropropizine).
OxolamineOxolamine is not approved in the USA, it may be marketed elsewhere internationally as a cough suppressant . It is listed as a prescription drug in New Zealand legislation ....
GuacetisalNot Annotated
ZipeprolNot Annotated
DropropizineNot Annotated
DimemorfanNot Annotated
ClofedanolAn antitussive used for the symptomatic relief of acute cough caused by minor throat and bronchial irritation.
EucalyptolA common ingredient in mouthwash and cosmetics derived naturally from the eucalyptus plant that is frequently used to to improve symptoms of airway mucus hypersecretion.
LevopropoxypheneLevopropoxyphene was used as an antitussive. An antitussive is a medication often recommended for the treatment of cough and associated respiratory tract disorders. Its enantiomer, dextropropoxyphene, presents an analgesic effect.
Drugs & Drug Targets
CodeineMu-type opioid receptortarget
CodeineDelta-type opioid receptortarget
CodeineKappa-type opioid receptortarget
CodeineCytochrome P450 2D6enzyme
CodeineCytochrome P450 3A4enzyme
CodeineSolute carrier family 22 member 1transporter
CodeineUDP-glucuronosyltransferase 2B7enzyme
CodeineUDP-glucuronosyltransferase 2B4enzyme
DextromethorphanSigma non-opioid intracellular receptor 1target
DextromethorphanHCG20471, isoform CRA_ctarget
DextromethorphanNeuronal acetylcholine receptor subunit alpha-2target
DextromethorphanSodium-dependent serotonin transportertarget
DextromethorphanGlutamate receptor ionotropic, NMDA 3Atarget
DextromethorphanCytochrome P450 2D6enzyme
DextromethorphanCytochrome P450 3A4enzyme
DextromethorphanCytochrome P450 3A7enzyme
DextromethorphanCytochrome P450 2C9enzyme
DextromethorphanCytochrome P450 2B6enzyme
DextromethorphanCytochrome P450 2C19enzyme
DextromethorphanMembrane-associated progesterone receptor component 1target
DextromethorphanNeuronal acetylcholine receptor subunit alpha-3target
DextromethorphanNeuronal acetylcholine receptor subunit alpha-4target
DextromethorphanNeuronal acetylcholine receptor subunit beta-4target
DextromethorphanNeuronal acetylcholine receptor subunit beta-2target
DextromethorphanNeuronal acetylcholine receptor subunit alpha-7target
DextromethorphanMu-type opioid receptortarget
DextromethorphanDelta-type opioid receptortarget
DextromethorphanKappa-type opioid receptortarget
DextromethorphanNADPH oxidasetarget
DextromethorphanSodium-dependent noradrenaline transportertarget
HydrocodoneMu-type opioid receptortarget
HydrocodoneDelta-type opioid receptortarget
HydrocodoneCytochrome P450 3A4enzyme
HydrocodoneCytochrome P450 2D6enzyme
HydrocodoneCytochrome P450 2B6enzyme
HydrocodoneCytochrome P450 2C19enzyme
HydrocodoneSigma non-opioid intracellular receptor 1target
MethadoneNMDA receptortarget
MethadoneMu-type opioid receptortarget
MethadoneCytochrome P450 2B6enzyme
MethadoneCytochrome P450 3A4enzyme
MethadoneCytochrome P450 2C19enzyme
MethadoneDelta-type opioid receptortarget
MethadoneCytochrome P450 3A7enzyme
MethadoneCytochrome P450 2D6enzyme
MethadoneP-glycoprotein 1transporter
MethadoneCytochrome P450 2C8enzyme
MethadoneCytochrome P450 19A1enzyme
MethadoneCytochrome P450 1A2enzyme
MethadoneCytochrome P450 2C18enzyme
MethadoneCytochrome P450 2C9enzyme
Methadone5-hydroxytryptamine receptor 3Atarget
MethadoneAlpha-1-acid glycoprotein 1carrier
MethadoneSerum albumincarrier
MethadoneNeuronal acetylcholine receptor subunit alpha-7target
MethadoneNeuronal acetylcholine receptor subunit alpha-3target
MethadoneNeuronal acetylcholine receptor subunit alpha-4target
MethadoneNeuronal acetylcholine receptor subunit beta-2target
ButorphanolKappa-type opioid receptortarget
ButorphanolMu-type opioid receptortarget
ButorphanolDelta-type opioid receptortarget
BenzonatateSodium channel protein type 5 subunit alphatarget
EthylmorphineCytochrome P450 2D6enzyme
EthylmorphineNADPH--cytochrome P450 reductaseenzyme
EthylmorphineMu-type opioid receptortarget
EthylmorphineCytochrome P450 2B6enzyme
EthylmorphineCytochrome P450 3A4enzyme
NoscapineSigma non-opioid intracellular receptor 1target
NoscapineCytochrome P450 2C9enzyme
NoscapineCytochrome P450 3A4enzyme
PholcodineMu-type opioid receptortarget
PholcodineKappa-type opioid receptortarget
PholcodineDelta-type opioid receptortarget
DoxofyllinePhosphodiesterase 2A, cGMP-stimulatedtarget
DoxofyllineAdenosine receptor A2atarget
DoxofyllineBeta-2 adrenergic receptortarget
DoxofyllineCytochrome P450 1A2enzyme
OpiumDelta-type opioid receptortarget
OpiumKappa-type opioid receptortarget
OpiumMu-type opioid receptortarget
OpiumSerum albumincarrier
OpiumCytochrome P450 2D6enzyme
OpiumCytochrome P450 3A4enzyme
PentoxyverineSigma non-opioid intracellular receptor 1target
PentoxyverinePotassium voltage-gated channel subfamily H member 2target
PentoxyverineVoltage-gated sodium channel alpha subunittarget
PentoxyverineKappa-type opioid receptortarget
PentoxyverineMu-type opioid receptortarget
ClofedanolHistamine H1 receptortarget