Identification

Name
Dextromethorphan
Accession Number
DB00514  (APRD00655)
Type
Small Molecule
Groups
Approved
Description

The d-isomer of the codeine analog of levorphanol. Dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (receptors, N-methyl-D-aspartate) and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity. [PubChem]

Structure
Thumb
Synonyms
  • (+)-dextromethorphan
  • D-methorphan
  • delta-Methorphan
  • Dex
  • Dextromethorfan
  • Dextromethorphan
  • Dextrométhorphane
  • Dextromethorphanum
  • Dextrometorfano
  • DM
External IDs
BA 2666
Product Ingredients
IngredientUNIICASInChI Key
Dextromethorphan hydriodide086F8ZEM777487-74-3RWSHVMCJJPXQSP-URVXVIKDSA-N
Dextromethorphan hydrobromideZ0CG3115FG125-69-9MISZALMBODQYFT-URVXVIKDSA-N
Dextromethorphan hydrobromide monohydrate9D2RTI9KYH6700-34-1STTADZBLEUMJRG-IKNOHUQMSA-N
Active Moieties
NameKindUNIICASInChI Key
Dextrorphanprodrug04B7QNO9WS125-73-5JAQUASYNZVUNQP-PVAVHDDUSA-N
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Cough Syrup DMSyrup15 mgOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.Not applicableNot applicableCanada
DM 7.5mg Croquable (chewable Tablet)Tablet, chewable7.5 mgOralLaboratoire Riva IncNot applicableNot applicableCanada
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
12 Hour Cough ReliefSuspension30 mg/5mLOralWestern Family Foods2012-09-142017-05-01Us
12 Hour Cough ReliefSuspension30 mg/5mLOralWestern Family Foods2013-07-032017-04-01Us
7 Select Cough DMSuspension30 mg/5mLOral7 Eleven2014-09-052016-10-01Us
Adult Cough Relief DMLiquid30 mg/10mLOralSafeway2014-06-30Not applicableUs
Adult Honey WorksSyrup20 mgOralLifelab Health LlcNot applicableNot applicableCanada
Adult Long Lasting-Cough ReliefCapsule15 mg/1OralChain Drug Consortium2013-05-22Not applicableUs
Adult Tussin CoughLiquid30 mg/10mLOralWestern Family Foods1992-09-112017-08-09Us
Adult Tussin Cough GelsCapsule, gelatin coated15 mg/1OralArmy + Air Force Exchange Service2006-04-242018-08-27Us
Adult Wal Tussin Cough Long ActingSolution30 mg/10mLOralWalgreen2004-09-03Not applicableUs
Balminil DMSyrup3 mgOralTeva1979-12-31Not applicableCanada
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
7 Select Day Time ReliefDextromethorphan hydrobromide monohydrate (10 mg/15mL) + Acetaminophen (325 mg/15mL) + Phenylephrine hydrochloride (5 mg/15mL)SolutionOral7 Eleven2014-08-05Not applicableUs
7 Select Day Time ReliefDextromethorphan hydrobromide monohydrate (10 mg/1) + Acetaminophen (325 mg/1) + Phenylephrine hydrochloride (5 mg/1)Capsule, liquid filledOral7 Eleven2014-04-22Not applicableUs
7 Select Night Time ReliefDextromethorphan hydrobromide monohydrate (30 mg/30mL) + Acetaminophen (650 mg/30mL) + Doxylamine succinate (12.5 mg/30mL)SolutionOral7 Eleven2014-08-05Not applicableUs
7 Select Night Time ReliefDextromethorphan hydrobromide monohydrate (15 mg/1) + Acetaminophen (325 mg/1) + Doxylamine succinate (6.25 mg/1)Capsule, liquid filledOral7 Eleven2014-04-17Not applicableUs
7 select Tussin DMDextromethorphan hydrobromide monohydrate (20 mg/10mL) + Guaifenesin (200 mg/10mL)SolutionOral7 Eleven2016-05-31Not applicableUs
A.M. Cold Relief FormulaDextromethorphan hydrobromide (15.0 mg) + Acetaminophen (325.0 mg) + Pseudoephedrine hydrochloride (30.0 mg)CapsuleOralIvax Pharmaceuticals IncorporatedNot applicableNot applicableCanada
Abatuss DmxDextromethorphan hydrobromide monohydrate (15 mg/5mL) + Dexchlorpheniramine maleate (1 mg/5mL) + Pseudoephedrine hydrochloride (30 mg/5mL)LiquidOralKramer Novis.2014-05-25Not applicableUs
AccuHist PDXDextromethorphan hydrobromide monohydrate (2.5 mg/1mL) + Chlorpheniramine maleate (1 mg/1mL) + Phenylephrine hydrochloride (2.5 mg/1mL)SolutionOralTiber Laboratories, LLC2010-01-252013-04-30Us
Acetaminophen Dextromethorphan HBr Doxylamine succinate Phenylephrine HClDextromethorphan hydrobromide monohydrate (10 mg/1) + Acetaminophen (325 mg/1) + Doxylamine succinate (6.25 mg/1) + Phenylephrine hydrochloride (5 mg/1)Capsule, liquid filledOralCVS Health2017-11-30Not applicableUs
Acetaminophen Dextromethorphan HBr Doxylamine succinate Phenylephrine HClDextromethorphan hydrobromide monohydrate (10 mg/1) + Acetaminophen (325 mg/1) + Doxylamine succinate (6.25 mg/1) + Phenylephrine hydrochloride (5 mg/1)Capsule, liquid filledOralCvs Pharmacy,inc2017-07-07Not applicableUs
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Atuss DS Tannate SuspensionDextromethorphan hydrobromide monohydrate (30 mg/5mL) + Chlorpheniramine maleate (4 mg/5mL) + Pseudoephedrine hydrochloride (30 mg/5mL)SuspensionOralAtley Pharmaceuticals2006-11-21Not applicableUs
BPM Mal Phenyleph HCl DM HBrDextromethorphan hydrobromide monohydrate (20 mg/5mL) + Brompheniramine maleate (4 mg/5mL) + Phenylephrine hydrochloride (10 mg/5mL)LiquidOralRiver's Edge Pharmaceuticals, LLC2010-01-182012-01-31Us
Brom Mal Phenyl HCl Dex HBrDextromethorphan hydrobromide monohydrate (15 mg/5mL) + Brompheniramine maleate (4 mg/5mL) + Phenylephrine hydrochloride (7.5 mg/5mL)LiquidOralRiver's Edge Pharmaceuticals, LLC2010-02-102012-02-29Us
Bromdex DDextromethorphan hydrobromide monohydrate (30 mg/5mL) + Brompheniramine maleate (3 mg/5mL) + Pseudoephedrine hydrochloride (50 mg/5mL)SyrupOralBreckenridge Pharmaceutical, Inc.2009-07-212011-05-31Us
Bromhist PDXDextromethorphan hydrobromide monohydrate (5 mg/5mL) + Brompheniramine maleate (2 mg/5mL) + Guaifenesin (50 mg/5mL) + Phenylephrine hydrochloride (5 mg/5mL)SyrupOralCypress Pharmaceutical, Inc2006-04-282011-08-26Us
Brompheniramine Maleate, Pseudoephedrine Hydrochloride, Dextromethorphan HydrobromideDextromethorphan hydrobromide monohydrate (20 mg/5mL) + Brompheniramine maleate (4 mg/5mL) + Pseudoephedrine hydrochloride (20 mg/5mL)LiquidOralRiver's Edge Pharmaceuticals, LLC2010-01-182012-01-31Us
BrontussDextromethorphan hydrobromide monohydrate (20 mg/1) + Guaifenesin (400 mg/1)TabletOralPortal Pharmaceuticals2010-05-032012-05-31Us
Carbinoxamine/Pseudoephedrine/DMDextromethorphan hydrobromide monohydrate (4 mg/1mL) + Carbinoxamine Maleate (1 mg/1mL) + Pseudoephedrine hydrochloride (15 mg/1mL)LiquidOralPhysicians Total Care, Inc.2003-01-152007-08-08Us
Carbofed DMDextromethorphan hydrobromide monohydrate (15 mg/5mL) + Brompheniramine maleate (4 mg/5mL) + Pseudoephedrine hydrochloride (45 mg/5mL)SyrupOralHi Tech Pharmacal Co., Inc.2001-09-032011-11-03Us
Chlorphen Mal Dex HBr Pseudoeph HClDextromethorphan hydrobromide monohydrate (3 mg/1mL) + Chlorpheniramine maleate (.8 mg/1mL) + Pseudoephedrine hydrochloride (9 mg/1mL)Solution / dropsOralRiver's Edge Pharmaceuticals2010-02-152011-01-31Us
International/Other Brands
Benylin DM (McNeil) / Romilar (Bayer) / Triaminic (Novartis) / Vicks Formula 44 (Procter & Gamble)
Categories
UNII
7355X3ROTS
CAS number
125-71-3
Weight
Average: 271.404
Monoisotopic: 271.193614429
Chemical Formula
C18H25NO
InChI Key
MKXZASYAUGDDCJ-NJAFHUGGSA-N
InChI
InChI=1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m1/s1
IUPAC Name
(1S,9S,10S)-4-methoxy-17-methyl-17-azatetracyclo[7.5.3.0¹,¹⁰.0²,⁷]heptadeca-2(7),3,5-triene
SMILES
[H][C@]12CC3=C(C=C(OC)C=C3)[C@@]3(CCCC[C@]13[H])CCN2C

Pharmacology

Indication

For treatment and relief of dry cough.

Associated Conditions
Pharmacodynamics

Dextromethorphan suppresses the cough reflex by a direct action on the cough center in the medulla of the brain. Dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity.

Mechanism of action

Dextromethorphan is an opioid-like drug that binds to and acts as antagonist to the NMDA glutamatergic receptor, it is an agonist to the opioid sigma 1 and sigma 2 receptors, it is also an alpha3/beta4 nicotinic receptor antagonist and targets the serotonin reuptake pump. Dextromethorphan is rapidly absorbed from the gastrointestinal tract, where it enters the bloodstream and crosses the blood-brain barrier. The first-pass through the hepatic portal vein results in some of the drug being metabolized into an active metabolite of dextromethorphan, dextrorphan, the 3-hydroxy derivative of dextromethorphan.

TargetActionsOrganism
ASigma non-opioid intracellular receptor 1
agonist
Human
AHCG20471, isoform CRA_c
agonist
Human
AGlutamate receptor ionotropic, NMDA 3A
antagonist
Human
UNeuronal acetylcholine receptor subunit alpha-2
antagonist
Human
USodium-dependent serotonin transporter
inhibitor
Human
UMembrane-associated progesterone receptor component 1
binder
Human
UNeuronal acetylcholine receptor subunit alpha-3
antagonist
Human
UNeuronal acetylcholine receptor subunit alpha-4
antagonist
Human
UNeuronal acetylcholine receptor subunit beta-4
antagonist
Human
UNeuronal acetylcholine receptor subunit beta-2
antagonist
Human
UNeuronal acetylcholine receptor subunit alpha-7
antagonist
Human
UMu-type opioid receptor
agonist
Human
UDelta-type opioid receptor
agonist
Human
UKappa-type opioid receptor
agonist
Human
UNADPH oxidase
inhibitor
Human
USodium-dependent noradrenaline transporter
inhibitor
Human
Absorption

Rapidly absorbed from the gastrointestinal tract.

Volume of distribution
Not Available
Protein binding
Not Available
Metabolism

Hepatic. Rapidly and extensively metabolized to dextrorphan (active metabolite). One well known metabolic catalyst involved is a specific cytochrome P450 enzyme known as 2D6, or CYP2D6.

Route of elimination
Not Available
Half life

3-6 hours

Clearance
Not Available
Toxicity
Not Available
Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Interacting Gene/EnzymeAllele nameGenotype(s)Defining Change(s)Type(s)DescriptionDetails
Cytochrome P450 2D6CYP2D6*4(A;A)A Allele, homozygoteEffect Directly StudiedPatients with this genotype have reduced metabolism of dextromethorphan.Details
Cytochrome P450 2D6CYP2D6*6(-;-)T deletion, homozygoteEffect Directly StudiedPatients with this genotype have reduced metabolism of dextromethorphan.Details
Cytochrome P450 2D6CYP2D6*3Not AvailableC alleleEffect InferredPoor drug metabolizer, lower dose requirementsDetails
Cytochrome P450 2D6CYP2D6*5Not AvailableWhole-gene deletionEffect InferredPoor drug metabolizer, lower dose requirementsDetails
Cytochrome P450 2D6CYP2D6*7Not Available2935A>CEffect InferredPoor drug metabolizer, lower dose requirementsDetails
Cytochrome P450 2D6CYP2D6*8Not Available1758G>TEffect InferredPoor drug metabolizer, lower dose requirementsDetails
Cytochrome P450 2D6CYP2D6*11Not Available883G>CEffect InferredPoor drug metabolizer, lower dose requirementsDetails
Cytochrome P450 2D6CYP2D6*12Not Available124G>AEffect InferredPoor drug metabolizer, lower dose requirementsDetails
Cytochrome P450 2D6CYP2D6*13Not AvailableCYP2D7/2D6 hybrid gene structureEffect InferredPoor drug metabolizer, lower dose requirementsDetails
Cytochrome P450 2D6CYP2D6*14ANot Available1758G>AEffect InferredPoor drug metabolizer, lower dose requirementsDetails
Cytochrome P450 2D6CYP2D6*15Not Available137insT, 137_138insTEffect InferredPoor drug metabolizer, lower dose requirementsDetails
Cytochrome P450 2D6CYP2D6*19Not Available2539_2542delAACTEffect InferredPoor drug metabolizer, lower dose requirementsDetails
Cytochrome P450 2D6CYP2D6*20Not Available1973_1974insGEffect InferredPoor drug metabolizer, lower dose requirementsDetails
Cytochrome P450 2D6CYP2D6*21Not Available2573insCEffect InferredPoor drug metabolizer, lower dose requirementsDetails
Cytochrome P450 2D6CYP2D6*31Not Available-1770G>A / -1584C>G  … show all Effect InferredPoor drug metabolizer, lower dose requirementsDetails
Cytochrome P450 2D6CYP2D6*36Not Available100C>T / -1426C>T  … show all Effect InferredPoor drug metabolizer, lower dose requirementsDetails
Cytochrome P450 2D6CYP2D6*38Not Available2587_2590delGACTEffect InferredPoor drug metabolizer, lower dose requirementsDetails
Cytochrome P450 2D6CYP2D6*40Not Available1863_1864ins(TTT CGC CCC)2Effect InferredPoor drug metabolizer, lower dose requirementsDetails
Cytochrome P450 2D6CYP2D6*42Not Available3259_3260insGTEffect InferredPoor drug metabolizer, lower dose requirementsDetails
Cytochrome P450 2D6CYP2D6*44Not Available2950G>CEffect InferredPoor drug metabolizer, lower dose requirementsDetails
Cytochrome P450 2D6CYP2D6*47Not Available100C>T / -1426C>T  … show all Effect InferredPoor drug metabolizer, lower dose requirementsDetails
Cytochrome P450 2D6CYP2D6*51Not Available-1584C>G / -1235A>G  … show all Effect InferredPoor drug metabolizer, lower dose requirementsDetails
Cytochrome P450 2D6CYP2D6*56Not Available3201C>TEffect InferredPoor drug metabolizer, lower dose requirementsDetails
Cytochrome P450 2D6CYP2D6*57Not Available100C>T / 310G>T  … show all Effect InferredPoor drug metabolizer, lower dose requirementsDetails
Cytochrome P450 2D6CYP2D6*62Not Available4044C>TEffect InferredPoor drug metabolizer, lower dose requirementsDetails
Cytochrome P450 2D6CYP2D6*68ANot Available-1426C>T / -1235A>G  … show all Effect InferredPoor drug metabolizer, lower dose requirementsDetails
Cytochrome P450 2D6CYP2D6*68BNot AvailableSimilar but not identical switch region compared to CYP2D6*68A. Found in tandem arrangement with CYP2D6*4.Effect InferredPoor drug metabolizer, lower dose requirementsDetails
Cytochrome P450 2D6CYP2D6*69Not Available2988G>A / -1426C>T  … show all Effect InferredPoor drug metabolizer, lower dose requirementsDetails
Cytochrome P450 2D6CYP2D6*92Not Available1995delCEffect InferredPoor drug metabolizer, lower dose requirementsDetails
Cytochrome P450 2D6CYP2D6*100Not Available-1426C>T / -1235A>G  … show all Effect InferredPoor drug metabolizer, lower dose requirementsDetails
Cytochrome P450 2D6CYP2D6*101Not Available-1426C>T / -1235A>G  … show all Effect InferredPoor drug metabolizer, lower dose requirementsDetails

Interactions

Drug Interactions
DrugInteractionDrug group
(2-benzhydryloxyethyl)diethyl-methylammonium iodideThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with (2-benzhydryloxyethyl)diethyl-methylammonium iodide.Experimental
1,10-PhenanthrolineThe therapeutic efficacy of Dextromethorphan can be decreased when used in combination with 1,10-Phenanthroline.Experimental
2,5-Dimethoxy-4-ethylamphetamineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with 2,5-Dimethoxy-4-ethylamphetamine.Experimental, Illicit
2,5-Dimethoxy-4-ethylthioamphetamineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with 2,5-Dimethoxy-4-ethylthioamphetamine.Experimental
3,4-MethylenedioxyamphetamineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with 3,4-Methylenedioxyamphetamine.Experimental, Illicit
4-Bromo-2,5-dimethoxyamphetamineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with 4-Bromo-2,5-dimethoxyamphetamine.Experimental, Illicit
4-MethoxyamphetamineThe risk or severity of adverse effects can be increased when 4-Methoxyamphetamine is combined with Dextromethorphan.Experimental, Illicit
5-methoxy-N,N-dimethyltryptamineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with 5-methoxy-N,N-dimethyltryptamine.Experimental, Illicit
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Dextromethorphan.Experimental
7,8-Dichloro-1,2,3,4-tetrahydroisoquinolineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.Experimental
AbirateroneThe serum concentration of Dextromethorphan can be increased when it is combined with Abiraterone.Approved
AcepromazineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Acepromazine.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Aceprometazine.Approved
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Dextromethorphan.Approved, Vet Approved
AcetophenazineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Acetophenazine.Approved
Acetylglycinamide chloral hydrateThe risk or severity of adverse effects can be increased when Acetylglycinamide chloral hydrate is combined with Dextromethorphan.Experimental
AclidiniumThe risk or severity of adverse effects can be increased when Aclidinium is combined with Dextromethorphan.Approved
AdinazolamThe risk or severity of adverse effects can be increased when Adinazolam is combined with Dextromethorphan.Approved
AdipiplonThe risk or severity of adverse effects can be increased when Adipiplon is combined with Dextromethorphan.Investigational
AgmatineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Agmatine.Experimental, Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Dextromethorphan.Approved, Investigational
AlaproclateAlaproclate may increase the serotonergic activities of Dextromethorphan.Experimental
AlcuroniumThe risk or severity of adverse effects can be increased when Alcuronium is combined with Dextromethorphan.Experimental
AlfaxaloneThe risk or severity of adverse effects can be increased when Alfaxalone is combined with Dextromethorphan.Vet Approved
AlfentanilThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Alfentanil.Approved, Illicit
AlimemazineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Alimemazine.Approved, Vet Approved
AllobarbitalThe risk or severity of adverse effects can be increased when Allobarbital is combined with Dextromethorphan.Experimental
AllopregnanoloneThe risk or severity of adverse effects can be increased when Allopregnanolone is combined with Dextromethorphan.Investigational
AlmotriptanThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Almotriptan.Approved, Investigational
AlosetronThe risk or severity of adverse effects can be increased when Alosetron is combined with Dextromethorphan.Approved, Withdrawn
AlphacetylmethadolThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Alphacetylmethadol.Experimental, Illicit
AlphaprodineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Alphaprodine.Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Dextromethorphan.Approved, Illicit, Investigational
AlprenololThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Alprenolol.Approved, Withdrawn
AlverineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Alverine.Approved, Investigational
AmantadineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Amantadine.Approved
AmbenoniumThe therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Ambenonium.Approved
AmikacinThe risk or severity of adverse effects can be increased when Amikacin is combined with Dextromethorphan.Approved, Investigational, Vet Approved
AmineptineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Amineptine.Illicit, Withdrawn
AmiodaroneThe metabolism of Dextromethorphan can be decreased when combined with Amiodarone.Approved, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Amisulpride.Approved, Investigational
AmitriptylineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Amitriptyline.Approved
AmitriptylinoxideThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Amitriptylinoxide.Approved, Investigational
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Dextromethorphan.Approved, Illicit
AmoxapineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Amoxapine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Amperozide.Experimental
AmphetamineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Amphetamine.Approved, Illicit, Investigational
AmprenavirThe metabolism of Dextromethorphan can be decreased when combined with Amprenavir.Approved, Investigational
AniracetamThe risk or severity of adverse effects can be increased when Aniracetam is combined with Dextromethorphan.Experimental
Anisotropine MethylbromideThe risk or severity of adverse effects can be increased when Anisotropine Methylbromide is combined with Dextromethorphan.Approved
ApalutamideThe serum concentration of Dextromethorphan can be decreased when it is combined with Apalutamide.Approved, Investigational
APD791The risk or severity of adverse effects can be increased when APD791 is combined with Dextromethorphan.Investigational
ApomorphineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Apomorphine.Approved, Investigational
ApramycinThe risk or severity of adverse effects can be increased when Apramycin is combined with Dextromethorphan.Experimental, Vet Approved
AprepitantThe serum concentration of Dextromethorphan can be increased when it is combined with Aprepitant.Approved, Investigational
AprobarbitalThe risk or severity of adverse effects can be increased when Aprobarbital is combined with Dextromethorphan.Approved, Illicit
ApronalideThe risk or severity of adverse effects can be increased when Apronalide is combined with Dextromethorphan.Experimental
Arbaclofen PlacarbilThe risk or severity of adverse effects can be increased when Arbaclofen Placarbil is combined with Dextromethorphan.Investigational
ArbekacinThe risk or severity of adverse effects can be increased when Arbekacin is combined with Dextromethorphan.Approved, Investigational
AripiprazoleThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Aripiprazole.Approved, Investigational
Aripiprazole lauroxilThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Aripiprazole lauroxil.Approved, Investigational
AsenapineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Asenapine.Approved
AsunaprevirThe serum concentration of Dextromethorphan can be increased when it is combined with Asunaprevir.Approved, Investigational, Withdrawn
AtazanavirThe metabolism of Dextromethorphan can be decreased when combined with Atazanavir.Approved, Investigational
AtomoxetineThe risk or severity of adverse effects can be increased when Atomoxetine is combined with Dextromethorphan.Approved
AtracuriumThe risk or severity of adverse effects can be increased when Atracurium is combined with Dextromethorphan.Approved, Experimental, Investigational
Atracurium besylateThe risk or severity of adverse effects can be increased when Atracurium besylate is combined with Dextromethorphan.Approved
AtropineThe risk or severity of adverse effects can be increased when Atropine is combined with Dextromethorphan.Approved, Vet Approved
AzaperoneThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Azaperone.Investigational, Vet Approved
AZD-3043The risk or severity of adverse effects can be increased when AZD-3043 is combined with Dextromethorphan.Investigational
AzelastineDextromethorphan may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Dextromethorphan.Approved
BarbexacloneThe risk or severity of adverse effects can be increased when Barbexaclone is combined with Dextromethorphan.Experimental
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Dextromethorphan.Illicit
Barbituric acid derivativeThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Barbituric acid derivative.Experimental, Illicit
BeclamideThe risk or severity of adverse effects can be increased when Beclamide is combined with Dextromethorphan.Experimental
BekanamycinThe risk or severity of adverse effects can be increased when Bekanamycin is combined with Dextromethorphan.Experimental
BenactyzineThe risk or severity of adverse effects can be increased when Benactyzine is combined with Dextromethorphan.Withdrawn
BendroflumethiazideThe serum concentration of Bendroflumethiazide can be increased when it is combined with Dextromethorphan.Approved
BenmoxinThe risk or severity of serotonin syndrome can be increased when Benmoxin is combined with Dextromethorphan.Withdrawn
BenperidolThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Benperidol.Approved, Investigational
BenzatropineThe risk or severity of adverse effects can be increased when Benzatropine is combined with Dextromethorphan.Approved
BenziloneThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Benzilone.Experimental
BenzoctamineThe risk or severity of adverse effects can be increased when Benzoctamine is combined with Dextromethorphan.Approved
BenzphetamineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Benzphetamine.Approved, Illicit
BenzquinamideThe risk or severity of adverse effects can be increased when Benzquinamide is combined with Dextromethorphan.Withdrawn
BenzthiazideThe serum concentration of Benzthiazide can be increased when it is combined with Dextromethorphan.Approved
Benzyl alcoholThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Dextromethorphan.Approved
BevoniumThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Bevonium.Experimental
BezitramideThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Bezitramide.Experimental, Illicit, Withdrawn
BifemelaneThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Bifemelane.Experimental
BifeprunoxThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Bifeprunox.Investigational
BiperidenThe risk or severity of adverse effects can be increased when Biperiden is combined with Dextromethorphan.Approved, Investigational
BL-1020The risk or severity of adverse effects can be increased when Dextromethorphan is combined with BL-1020.Investigational
BlonanserinThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Blonanserin.Approved, Investigational
BoceprevirThe metabolism of Dextromethorphan can be decreased when combined with Boceprevir.Approved, Withdrawn
BornaprineThe risk or severity of adverse effects can be increased when Bornaprine is combined with Dextromethorphan.Experimental
BortezomibThe metabolism of Dextromethorphan can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Dextromethorphan can be decreased when it is combined with Bosentan.Approved, Investigational
Botulinum Toxin Type AThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Botulinum Toxin Type A.Approved, Investigational
Botulinum Toxin Type BThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Botulinum Toxin Type B.Approved, Investigational
BrexpiprazoleThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Brexpiprazole.Approved, Investigational
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Dextromethorphan.Approved
BrivaracetamThe risk or severity of adverse effects can be increased when Brivaracetam is combined with Dextromethorphan.Approved, Investigational
BrofaromineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Brofaromine.Experimental
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Dextromethorphan.Approved, Illicit, Investigational
BromisovalThe risk or severity of adverse effects can be increased when Bromisoval is combined with Dextromethorphan.Experimental
BromocriptineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Bromocriptine.Approved, Investigational
BromperidolThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Bromperidol.Approved, Investigational
BrompheniramineThe risk or severity of adverse effects can be increased when Brompheniramine is combined with Dextromethorphan.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Dextromethorphan.Approved, Investigational, Withdrawn
BuclizineThe risk or severity of adverse effects can be increased when Buclizine is combined with Dextromethorphan.Approved
BufotenineThe risk or severity of adverse effects can be increased when Bufotenine is combined with Dextromethorphan.Experimental, Illicit
BuprenorphineDextromethorphan may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BupropionThe risk or severity of serotonin syndrome can be increased when Bupropion is combined with Dextromethorphan.Approved
BuspironeThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Buspirone.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Dextromethorphan.Approved, Illicit
ButalbitalThe risk or severity of adverse effects can be increased when Butalbital is combined with Dextromethorphan.Approved, Illicit
ButaperazineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Butaperazine.Experimental
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Dextromethorphan.Approved, Illicit
ButorphanolThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Butorphanol.Approved, Illicit, Vet Approved
ButriptylineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Butriptyline.Approved
ButylscopolamineThe risk or severity of adverse effects can be increased when Butylscopolamine is combined with Dextromethorphan.Approved, Investigational, Vet Approved
CabergolineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Cabergoline.Approved
CalcitriolThe metabolism of Dextromethorphan can be increased when combined with Calcitriol.Approved, Nutraceutical
CamazepamThe risk or severity of adverse effects can be increased when Camazepam is combined with Dextromethorphan.Approved, Illicit
CamylofinThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Camylofin.Experimental
CannabidiolThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Cannabidiol.Approved, Investigational
CannabidivarinThe risk or severity of adverse effects can be increased when Cannabidivarin is combined with Dextromethorphan.Investigational
CapreomycinThe risk or severity of adverse effects can be increased when Capreomycin is combined with Dextromethorphan.Approved
CaptodiameThe risk or severity of adverse effects can be increased when Captodiame is combined with Dextromethorphan.Approved, Investigational
CarbamazepineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Carbinoxamine is combined with Dextromethorphan.Approved
CarbromalThe risk or severity of adverse effects can be increased when Carbromal is combined with Dextromethorphan.Experimental
CarfentanilThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Carfentanil.Illicit, Investigational, Vet Approved
CariprazineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Cariprazine.Approved, Investigational
CarisbamateThe risk or severity of adverse effects can be increased when Carisbamate is combined with Dextromethorphan.Investigational
CarisoprodolThe risk or severity of adverse effects can be increased when Carisoprodol is combined with Dextromethorphan.Approved
CaroxazoneThe risk or severity of serotonin syndrome can be increased when Caroxazone is combined with Dextromethorphan.Withdrawn
CathinoneThe risk or severity of adverse effects can be increased when Cathinone is combined with Dextromethorphan.Illicit
CeritinibThe serum concentration of Dextromethorphan can be increased when it is combined with Ceritinib.Approved
CerlapirdineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Cerlapirdine.Investigational
CetirizineThe risk or severity of adverse effects can be increased when Cetirizine is combined with Dextromethorphan.Approved
CevimelineThe metabolism of Dextromethorphan can be decreased when combined with Cevimeline.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Dextromethorphan.Approved, Illicit, Investigational, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Dextromethorphan.Approved, Illicit, Investigational
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Dextromethorphan.Approved, Investigational, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Dextromethorphan.Approved
ChloroquineThe risk or severity of adverse effects can be increased when Chloroquine is combined with Dextromethorphan.Approved, Investigational, Vet Approved
ChlorothiazideThe serum concentration of Chlorothiazide can be increased when it is combined with Dextromethorphan.Approved, Vet Approved
ChlorphenamineThe risk or severity of serotonin syndrome can be increased when Chlorphenamine is combined with Dextromethorphan.Approved
ChlorphenesinThe risk or severity of adverse effects can be increased when Chlorphenesin is combined with Dextromethorphan.Approved, Experimental
ChlorphenoxamineThe risk or severity of adverse effects can be increased when Chlorphenoxamine is combined with Dextromethorphan.Withdrawn
ChlorphentermineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Chlorphentermine.Illicit, Withdrawn
ChlorproethazineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Chlorproethazine.Experimental
ChlorpromazineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Chlorpromazine.Approved, Investigational, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Chlorprothixene.Approved, Investigational, Withdrawn
ChlortetracyclineThe risk or severity of adverse effects can be increased when Chlortetracycline is combined with Dextromethorphan.Approved, Investigational, Vet Approved
ChlorthalidoneThe serum concentration of Chlorthalidone can be increased when it is combined with Dextromethorphan.Approved
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Dextromethorphan.Approved
CilansetronThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Cilansetron.Investigational
CimetidineThe metabolism of Dextromethorphan can be decreased when combined with Cimetidine.Approved, Investigational
CinacalcetThe metabolism of Dextromethorphan can be decreased when combined with Cinacalcet.Approved
CinitaprideThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Cinitapride.Approved, Investigational
CinolazepamThe risk or severity of adverse effects can be increased when Cinolazepam is combined with Dextromethorphan.Approved
CisaprideThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Cisapride.Approved, Investigational, Withdrawn
CisatracuriumThe risk or severity of adverse effects can be increased when Cisatracurium is combined with Dextromethorphan.Approved
CitalopramCitalopram may increase the serotonergic activities of Dextromethorphan.Approved
ClarithromycinThe metabolism of Dextromethorphan can be decreased when combined with Clarithromycin.Approved
ClemastineThe risk or severity of adverse effects can be increased when Clemastine is combined with Dextromethorphan.Approved, Investigational
ClidiniumThe risk or severity of adverse effects can be increased when Clidinium is combined with Dextromethorphan.Approved
ClindamycinThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Clindamycin.Approved, Vet Approved
ClobazamThe risk or severity of adverse effects can be increased when Clobazam is combined with Dextromethorphan.Approved, Illicit
Clobetasol propionateThe metabolism of Dextromethorphan can be increased when combined with Clobetasol propionate.Approved
clomethiazoleThe risk or severity of adverse effects can be increased when clomethiazole is combined with Dextromethorphan.Investigational
ClomipramineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Clomipramine.Approved, Investigational, Vet Approved
ClomocyclineThe risk or severity of adverse effects can be increased when Clomocycline is combined with Dextromethorphan.Approved
ClonazepamThe risk or severity of adverse effects can be increased when Clonazepam is combined with Dextromethorphan.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Clonidine is combined with Dextromethorphan.Approved
ClopenthixolThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Clopenthixol.Experimental
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Dextromethorphan.Approved, Illicit
ClothiapineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Clothiapine.Experimental
ClotiazepamThe risk or severity of adverse effects can be increased when Clotiazepam is combined with Dextromethorphan.Approved, Illicit
ClotrimazoleThe metabolism of Dextromethorphan can be decreased when combined with Clotrimazole.Approved, Vet Approved
CloxazolamThe risk or severity of adverse effects can be increased when Cloxazolam is combined with Dextromethorphan.Approved, Investigational
ClozapineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Clozapine.Approved
CobicistatThe serum concentration of Dextromethorphan can be increased when it is combined with Cobicistat.Approved
CocaineThe risk or severity of serotonin syndrome can be increased when Cocaine is combined with Dextromethorphan.Approved, Illicit
CodeineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Codeine.Approved, Illicit
ColistimethateThe risk or severity of adverse effects can be increased when Colistimethate is combined with Dextromethorphan.Approved, Vet Approved
ColistinThe risk or severity of adverse effects can be increased when Colistin is combined with Dextromethorphan.Approved
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Dextromethorphan.Approved, Investigational
CoumaphosThe therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Coumaphos.Vet Approved
CrizotinibThe metabolism of Dextromethorphan can be decreased when combined with Crizotinib.Approved
CurcuminThe metabolism of Dextromethorphan can be decreased when combined with Curcumin.Approved, Investigational
CyamemazineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Cyamemazine.Approved
CyclizineThe risk or severity of adverse effects can be increased when Cyclizine is combined with Dextromethorphan.Approved
CyclobarbitalThe risk or severity of adverse effects can be increased when Cyclobarbital is combined with Dextromethorphan.Experimental
CyclobenzaprineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Cyclobenzaprine.Approved
CyclopenthiazideThe serum concentration of Cyclopenthiazide can be increased when it is combined with Dextromethorphan.Approved
CyclopentolateThe risk or severity of adverse effects can be increased when Cyclopentolate is combined with Dextromethorphan.Approved
CyclopropaneThe risk or severity of adverse effects can be increased when Cyclopropane is combined with Dextromethorphan.Experimental
CyclosporineThe risk or severity of adverse effects can be increased when Cyclosporine is combined with Dextromethorphan.Approved, Investigational, Vet Approved
CycrimineThe risk or severity of adverse effects can be increased when Cycrimine is combined with Dextromethorphan.Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Cyproheptadine is combined with Dextromethorphan.Approved
DabrafenibThe serum concentration of Dextromethorphan can be decreased when it is combined with Dabrafenib.Approved, Investigational
DanazolThe metabolism of Dextromethorphan can be decreased when combined with Danazol.Approved
DantroleneThe risk or severity of adverse effects can be increased when Dantrolene is combined with Dextromethorphan.Approved, Investigational
DapiprazoleThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Dapiprazole.Approved
DapoxetineDapoxetine may increase the serotonergic activities of Dextromethorphan.Investigational
DarifenacinThe risk or severity of adverse effects can be increased when Darifenacin is combined with Dextromethorphan.Approved, Investigational
DarunavirThe serum concentration of Dextromethorphan can be increased when it is combined with Darunavir.Approved
DasatinibThe serum concentration of Dextromethorphan can be increased when it is combined with Dasatinib.Approved, Investigational
DeanolThe risk or severity of adverse effects can be increased when Deanol is combined with Dextromethorphan.Experimental
DecamethoniumThe therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Decamethonium.Approved
DeferasiroxThe serum concentration of Dextromethorphan can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Dextromethorphan can be decreased when combined with Delavirdine.Approved
DelorazepamThe risk or severity of adverse effects can be increased when Delorazepam is combined with Dextromethorphan.Approved, Illicit, Investigational
DemecariumThe therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Demecarium.Approved
DemeclocyclineThe risk or severity of adverse effects can be increased when Demeclocycline is combined with Dextromethorphan.Approved
DeramciclaneThe risk or severity of adverse effects can be increased when Deramciclane is combined with Dextromethorphan.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Dextromethorphan.Approved
DesipramineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Desipramine.Approved, Investigational
DesloratadineThe risk or severity of adverse effects can be increased when Desloratadine is combined with Dextromethorphan.Approved, Investigational
DesvenlafaxineDesvenlafaxine may increase the serotonergic activities of Dextromethorphan.Approved, Investigational
DetomidineThe risk or severity of adverse effects can be increased when Detomidine is combined with Dextromethorphan.Vet Approved
DexamethasoneThe serum concentration of Dextromethorphan can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Dextromethorphan.Approved
DexetimideThe risk or severity of adverse effects can be increased when Dexetimide is combined with Dextromethorphan.Withdrawn
DexfenfluramineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Dexfenfluramine.Approved, Illicit, Investigational, Withdrawn
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Dextromethorphan.Approved, Vet Approved
DexmethylphenidateThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Dexmethylphenidate.Approved, Investigational
DextofisopamThe risk or severity of adverse effects can be increased when Dextofisopam is combined with Dextromethorphan.Investigational
DextroamphetamineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Dextroamphetamine.Approved, Illicit
DextromoramideThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Dextromoramide.Experimental, Illicit
DextropropoxypheneThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Dextropropoxyphene.Approved, Illicit, Investigational, Withdrawn
DezocineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Dezocine.Approved, Investigational
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Dextromethorphan.Approved, Illicit, Investigational, Vet Approved
DibekacinThe risk or severity of adverse effects can be increased when Dibekacin is combined with Dextromethorphan.Experimental
DibenzepinThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Dibenzepin.Experimental
DichloralphenazoneThe risk or severity of adverse effects can be increased when Dichloralphenazone is combined with Dextromethorphan.Approved, Illicit
DichlorvosThe therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Dichlorvos.Vet Approved
DicyclomineThe risk or severity of adverse effects can be increased when Dicyclomine is combined with Dextromethorphan.Approved
Diethyl etherThe risk or severity of adverse effects can be increased when Diethyl ether is combined with Dextromethorphan.Experimental
DiethylpropionThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Diethylpropion.Approved, Illicit
DifemerineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Difemerine.Experimental
DifenoxinThe risk or severity of adverse effects can be increased when Difenoxin is combined with Dextromethorphan.Approved, Illicit
DihexyverineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Dihexyverine.Experimental
DihydrocodeineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Dihydrocodeine.Approved, Illicit
DihydroergotamineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Dihydroergotamine.Approved, Investigational
DihydroetorphineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Dihydroetorphine.Experimental, Illicit
DihydromorphineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Dihydromorphine.Experimental, Illicit
DihydrostreptomycinThe risk or severity of adverse effects can be increased when Dihydrostreptomycin is combined with Dextromethorphan.Investigational, Vet Approved
DiltiazemThe metabolism of Dextromethorphan can be decreased when combined with Diltiazem.Approved, Investigational
DimenhydrinateThe risk or severity of adverse effects can be increased when Dimenhydrinate is combined with Dextromethorphan.Approved
DimetacrineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Dimetacrine.Approved, Withdrawn
DimethyltryptamineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Dimethyltryptamine.Experimental, Illicit
DimetindeneThe risk or severity of adverse effects can be increased when Dimetindene is combined with Dextromethorphan.Approved, Investigational
DiphemanilThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Diphemanil.Experimental
Diphemanil MethylsulfateThe risk or severity of adverse effects can be increased when Diphemanil Methylsulfate is combined with Dextromethorphan.Approved, Vet Approved, Withdrawn
DiphenhydramineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Diphenhydramine.Approved, Investigational
DiphenidolThe risk or severity of adverse effects can be increased when Diphenidol is combined with Dextromethorphan.Approved, Investigational, Withdrawn
DiphenoxylateThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Diphenoxylate.Approved, Illicit
DisopyramideThe risk or severity of adverse effects can be increased when Disopyramide is combined with Dextromethorphan.Approved
DistigmineThe therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Distigmine.Experimental
DixyrazineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Dixyrazine.Experimental
DofetilideThe metabolism of Dofetilide can be decreased when combined with Dextromethorphan.Approved, Investigational
DolasetronThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Dolasetron.Approved, Investigational
Domoic AcidThe risk or severity of adverse effects can be increased when Domoic Acid is combined with Dextromethorphan.Experimental
DonepezilThe therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Donepezil.Approved
DoramectinThe risk or severity of adverse effects can be increased when Doramectin is combined with Dextromethorphan.Vet Approved
DosulepinThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Dosulepin.Approved
DotarizineThe risk or severity of adverse effects can be increased when Dotarizine is combined with Dextromethorphan.Investigational
DoxacuriumThe risk or severity of adverse effects can be increased when Doxacurium is combined with Dextromethorphan.Approved
DoxefazepamThe risk or severity of adverse effects can be increased when Doxefazepam is combined with Dextromethorphan.Experimental
DoxepinThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Doxepin.Approved, Investigational
DoxycyclineThe metabolism of Dextromethorphan can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Dextromethorphan.Approved, Vet Approved
DPDPEThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with DPDPE.Experimental
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Dextromethorphan.Approved, Illicit
DronedaroneThe metabolism of Dextromethorphan can be decreased when combined with Dronedarone.Approved
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Dextromethorphan.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Dextromethorphan.Experimental, Illicit
DuloxetineDuloxetine may increase the serotonergic activities of Dextromethorphan.Approved
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Dextromethorphan.Approved
EchothiophateThe therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Echothiophate.Approved
EcopipamThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Ecopipam.Investigational
EdivoxetineThe risk or severity of adverse effects can be increased when Edivoxetine is combined with Dextromethorphan.Investigational
EdrophoniumThe therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Edrophonium.Approved
EfavirenzThe metabolism of Dextromethorphan can be decreased when combined with Efavirenz.Approved, Investigational
EletriptanThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Eletriptan.Approved, Investigational
EltanoloneThe risk or severity of adverse effects can be increased when Eltanolone is combined with Dextromethorphan.Investigational
EltoprazineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Eltoprazine.Investigational
EluxadolineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Eluxadoline.Approved, Investigational
EmeproniumThe risk or severity of adverse effects can be increased when Emepronium is combined with Dextromethorphan.Experimental
EmylcamateThe risk or severity of adverse effects can be increased when Emylcamate is combined with Dextromethorphan.Experimental
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Dextromethorphan.Approved, Investigational, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Entacapone is combined with Dextromethorphan.Approved, Investigational
EnzalutamideThe serum concentration of Dextromethorphan can be decreased when it is combined with Enzalutamide.Approved
EperisoneThe risk or severity of adverse effects can be increased when Eperisone is combined with Dextromethorphan.Approved, Investigational
EpinastineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Epinastine.Approved, Investigational
EpitizideThe serum concentration of Epitizide can be increased when it is combined with Dextromethorphan.Experimental
EplivanserinThe risk or severity of adverse effects can be increased when Eplivanserin is combined with Dextromethorphan.Investigational
ErgocalciferolThe metabolism of Dextromethorphan can be decreased when combined with Ergocalciferol.Approved, Nutraceutical
Ergoloid mesylateThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Ergoloid mesylate.Approved
ErgonovineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Ergonovine.Approved
ErgotamineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Ergotamine.Approved
ErythromycinThe metabolism of Dextromethorphan can be decreased when combined with Erythromycin.Approved, Investigational, Vet Approved
EscitalopramEscitalopram may increase the serotonergic activities of Dextromethorphan.Approved, Investigational
Eslicarbazepine acetateThe risk or severity of adverse effects can be increased when Eslicarbazepine acetate is combined with Dextromethorphan.Approved
EsmirtazapineThe risk or severity of adverse effects can be increased when Esmirtazapine is combined with Dextromethorphan.Investigational
EsreboxetineThe risk or severity of adverse effects can be increased when Esreboxetine is combined with Dextromethorphan.Investigational
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Dextromethorphan.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Dextromethorphan.Approved, Investigational
Etacrynic acidThe risk or severity of adverse effects can be increased when Etacrynic acid is combined with Dextromethorphan.Approved, Investigational
EtanautineThe risk or severity of adverse effects can be increased when Etanautine is combined with Dextromethorphan.Experimental
EthadioneThe risk or severity of adverse effects can be increased when Ethadione is combined with Dextromethorphan.Experimental
EthanolDextromethorphan may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Dextromethorphan.Approved, Illicit, Withdrawn
EthopropazineThe risk or severity of adverse effects can be increased when Ethopropazine is combined with Dextromethorphan.Approved
EthosuximideThe risk or severity of adverse effects can be increased when Ethosuximide is combined with Dextromethorphan.Approved
EthotoinThe risk or severity of adverse effects can be increased when Ethotoin is combined with Dextromethorphan.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Dextromethorphan.Withdrawn
Ethyl chlorideThe risk or severity of adverse effects can be increased when Ethyl chloride is combined with Dextromethorphan.Approved, Experimental, Investigational
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Dextromethorphan.Approved, Illicit
EthylmorphineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Ethylmorphine.Approved, Illicit
EtifoxineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Dextromethorphan.Investigational, Withdrawn
EtiracetamThe risk or severity of adverse effects can be increased when Etiracetam is combined with Dextromethorphan.Investigational
EtizolamThe risk or severity of adverse effects can be increased when Etizolam is combined with Dextromethorphan.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Dextromethorphan.Approved
EtoperidoneThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Etoperidone.Withdrawn
EtoposideThe metabolism of Dextromethorphan can be increased when combined with Etoposide.Approved
EtorphineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Etorphine.Illicit, Vet Approved
EtravirineThe serum concentration of Dextromethorphan can be decreased when it is combined with Etravirine.Approved
EtybenzatropineThe risk or severity of adverse effects can be increased when Etybenzatropine is combined with Dextromethorphan.Experimental
EzogabineThe risk or severity of adverse effects can be increased when Ezogabine is combined with Dextromethorphan.Approved, Investigational
FabomotizoleThe risk or severity of adverse effects can be increased when Fabomotizole is combined with Dextromethorphan.Experimental
Fazadinium bromideThe risk or severity of adverse effects can be increased when Fazadinium bromide is combined with Dextromethorphan.Experimental
FebarbamateThe risk or severity of adverse effects can be increased when Febarbamate is combined with Dextromethorphan.Experimental
FelbamateThe risk or severity of adverse effects can be increased when Felbamate is combined with Dextromethorphan.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Dextromethorphan.Approved, Illicit, Withdrawn
FenfluramineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Fenfluramine.Approved, Illicit, Investigational, Withdrawn
FenpiveriniumThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Fenpiverinium.Experimental
FentanylThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Fentanyl.Approved, Illicit, Investigational, Vet Approved
FenthionThe therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Fenthion.Vet Approved
FenyramidolThe risk or severity of adverse effects can be increased when Fenyramidol is combined with Dextromethorphan.Experimental
FesoterodineThe risk or severity of adverse effects can be increased when Fesoterodine is combined with Dextromethorphan.Approved
FexofenadineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Dextromethorphan.Approved, Investigational
FlavoxateThe risk or severity of adverse effects can be increased when Flavoxate is combined with Dextromethorphan.Approved
FlibanserinThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Flibanserin.Approved, Investigational
FluanisoneThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Fluanisone.Experimental
FluconazoleThe metabolism of Dextromethorphan can be decreased when combined with Fluconazole.Approved, Investigational
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Dextromethorphan.Approved, Illicit
FlunarizineThe risk or severity of adverse effects can be increased when Flunarizine is combined with Dextromethorphan.Approved
FlunisolideThe metabolism of Dextromethorphan can be increased when combined with Flunisolide.Approved, Investigational
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Dextromethorphan.Approved, Illicit
Fluocinolone acetonideThe metabolism of Dextromethorphan can be increased when combined with Fluocinolone Acetonide.Approved, Investigational, Vet Approved
FluoxetineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Flupentixol.Approved, Investigational, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Fluphenazine.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Dextromethorphan.Approved, Illicit, Investigational
FluspirileneThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Fluspirilene.Approved, Investigational
Fluticasone propionateThe risk or severity of adverse effects can be increased when Fluticasone propionate is combined with Dextromethorphan.Approved
FluvastatinThe metabolism of Dextromethorphan can be increased when combined with Fluvastatin.Approved
FluvoxamineFluvoxamine may increase the serotonergic activities of Dextromethorphan.Approved, Investigational
Folic AcidThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Dextromethorphan.Approved, Nutraceutical, Vet Approved
FosamprenavirThe metabolism of Dextromethorphan can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Dextromethorphan can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe metabolism of Dextromethorphan can be increased when combined with Fosphenytoin.Approved, Investigational
FospropofolThe risk or severity of adverse effects can be increased when Fospropofol is combined with Dextromethorphan.Approved, Illicit, Investigational
FramycetinThe risk or severity of adverse effects can be increased when Framycetin is combined with Dextromethorphan.Approved
FrovatriptanThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Frovatriptan.Approved, Investigational
FurazolidoneThe risk or severity of serotonin syndrome can be increased when Furazolidone is combined with Dextromethorphan.Approved, Investigational, Vet Approved
Fusidic AcidThe serum concentration of Dextromethorphan can be increased when it is combined with Fusidic Acid.Approved, Investigational
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Dextromethorphan.Approved, Investigational
Gabapentin enacarbilThe risk or severity of adverse effects can be increased when Gabapentin Enacarbil is combined with Dextromethorphan.Approved, Investigational
GaboxadolThe risk or severity of adverse effects can be increased when Gaboxadol is combined with Dextromethorphan.Investigational
GalantamineThe therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Galantamine.Approved
GallamineThe risk or severity of adverse effects can be increased when Gallamine is combined with Dextromethorphan.Experimental
Gallamine TriethiodideThe therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Gallamine Triethiodide.Approved
Gamma hydroxybutyric acidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Dextromethorphan.Approved, Illicit, Investigational
Gantacurium ChlorideThe risk or severity of adverse effects can be increased when Gantacurium Chloride is combined with Dextromethorphan.Investigational
GedocarnilThe risk or severity of adverse effects can be increased when Gedocarnil is combined with Dextromethorphan.Experimental
GeneticinThe risk or severity of adverse effects can be increased when Geneticin is combined with Dextromethorphan.Experimental
GentamicinThe risk or severity of adverse effects can be increased when Gentamicin is combined with Dextromethorphan.Approved, Vet Approved
GENTAMICIN C1AThe risk or severity of adverse effects can be increased when GENTAMICIN C1A is combined with Dextromethorphan.Experimental
GepefrineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Gepefrine.Experimental
GepironeThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Gepirone.Investigational
Ginkgo bilobaThe therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Ginkgo biloba.Approved, Investigational, Nutraceutical
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Dextromethorphan.Approved, Illicit
Glycerol phenylbutyrateThe metabolism of Dextromethorphan can be decreased when combined with Glycerol Phenylbutyrate.Approved
GlycopyrroniumThe risk or severity of adverse effects can be increased when Glycopyrronium is combined with Dextromethorphan.Approved, Investigational, Vet Approved
GranisetronThe risk or severity of serotonin syndrome can be increased when Granisetron is combined with Dextromethorphan.Approved, Investigational
GuanfacineThe risk or severity of adverse effects can be increased when Guanfacine is combined with Dextromethorphan.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Dextromethorphan.Approved, Illicit, Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Haloperidol.Approved
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Dextromethorphan.Approved, Vet Approved
HarmalineThe risk or severity of serotonin syndrome can be increased when Harmaline is combined with Dextromethorphan.Experimental
HeptabarbitalThe risk or severity of adverse effects can be increased when Heptabarbital is combined with Dextromethorphan.Approved
HeroinThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Heroin.Approved, Illicit, Investigational
HexafluroniumThe risk or severity of adverse effects can be increased when Hexafluronium is combined with Dextromethorphan.Approved
HexamethoniumThe risk or severity of adverse effects can be increased when Hexamethonium is combined with Dextromethorphan.Experimental
HexapropymateThe risk or severity of adverse effects can be increased when Hexapropymate is combined with Dextromethorphan.Experimental
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Dextromethorphan.Approved
HexocycliumThe risk or severity of adverse effects can be increased when Hexocyclium is combined with Dextromethorphan.Approved
HomatropineThe risk or severity of adverse effects can be increased when Homatropine is combined with Dextromethorphan.Approved
Homatropine MethylbromideThe risk or severity of adverse effects can be increased when Homatropine Methylbromide is combined with Dextromethorphan.Approved
Huperzine AThe therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Huperzine A.Approved, Investigational
HydracarbazineThe risk or severity of serotonin syndrome can be increased when Hydracarbazine is combined with Dextromethorphan.Experimental
HydrochlorothiazideThe serum concentration of Hydrochlorothiazide can be increased when it is combined with Dextromethorphan.Approved, Vet Approved
HydrocodoneDextromethorphan may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit, Investigational
HydrocortisoneThe metabolism of Dextromethorphan can be increased when combined with Hydrocortisone.Approved, Vet Approved
HydroflumethiazideThe serum concentration of Hydroflumethiazide can be increased when it is combined with Dextromethorphan.Approved, Investigational
HydromorphoneThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Hydromorphone.Approved, Illicit
HydroxyamphetamineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Hydroxyamphetamine.Approved
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Dextromethorphan.Approved
Hygromycin BThe risk or severity of adverse effects can be increased when Hygromycin B is combined with Dextromethorphan.Vet Approved
HyoscyamineThe risk or severity of adverse effects can be increased when Hyoscyamine is combined with Dextromethorphan.Approved
HypericinThe risk or severity of adverse effects can be increased when Hypericin is combined with Dextromethorphan.Investigational
IdalopirdineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Idalopirdine.Investigational
IdelalisibThe metabolism of Dextromethorphan can be decreased when combined with Idelalisib.Approved
IfenprodilThe risk or severity of adverse effects can be increased when Ifenprodil is combined with Dextromethorphan.Approved, Investigational, Withdrawn
IferanserinThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Iferanserin.Investigational
IloperidoneThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Iloperidone.Approved
ImagabalinThe risk or severity of adverse effects can be increased when Imagabalin is combined with Dextromethorphan.Investigational
ImatinibThe metabolism of Dextromethorphan can be decreased when combined with Imatinib.Approved
ImidafenacinThe risk or severity of adverse effects can be increased when Imidafenacin is combined with Dextromethorphan.Approved, Investigational
ImipramineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Imipramine.Approved
Imipramine oxideThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Imipramine oxide.Experimental
IndalpineIndalpine may increase the serotonergic activities of Dextromethorphan.Investigational, Withdrawn
IndapamideThe serum concentration of Indapamide can be increased when it is combined with Dextromethorphan.Approved
IndinavirThe metabolism of Dextromethorphan can be decreased when combined with Indinavir.Approved
IndiplonThe risk or severity of adverse effects can be increased when Indiplon is combined with Dextromethorphan.Investigational
Iofetamine I-123The risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Iofetamine I-123.Approved
IpidacrineThe therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Ipidacrine.Experimental
IpratropiumThe risk or severity of adverse effects can be increased when Ipratropium is combined with Dextromethorphan.Approved
IprazochromeThe risk or severity of adverse effects can be increased when Iprazochrome is combined with Dextromethorphan.Experimental
IprindoleThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Iprindole.Experimental
IproclozideThe risk or severity of adverse effects can be increased when Iproclozide is combined with Dextromethorphan.Withdrawn
IproniazidThe risk or severity of serotonin syndrome can be increased when Iproniazid is combined with Dextromethorphan.Withdrawn
IsavuconazoleThe serum concentration of Dextromethorphan can be increased when it is combined with Isavuconazole.Approved, Investigational
IsavuconazoniumThe metabolism of Dextromethorphan can be decreased when combined with Isavuconazonium.Approved, Investigational
IsepamicinThe risk or severity of adverse effects can be increased when Isepamicin is combined with Dextromethorphan.Experimental
IsocarboxazidThe risk or severity of serotonin syndrome can be increased when Isocarboxazid is combined with Dextromethorphan.Approved
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Dextromethorphan.Approved, Vet Approved
IsoflurophateThe therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Isoflurophate.Approved, Investigational, Withdrawn
IsoniazidThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Isoniazid.Approved, Investigational
IsopropamideThe risk or severity of adverse effects can be increased when Isopropamide is combined with Dextromethorphan.Approved, Vet Approved
ItoprideThe therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Itopride.Investigational
ItraconazoleThe metabolism of Dextromethorphan can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Dextromethorphan can be increased when it is combined with Ivacaftor.Approved
KanamycinThe risk or severity of adverse effects can be increased when Kanamycin is combined with Dextromethorphan.Approved, Investigational, Vet Approved
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Dextromethorphan.Approved, Vet Approved
KetanserinThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Ketanserin.Investigational
KetazolamThe risk or severity of adverse effects can be increased when Ketazolam is combined with Dextromethorphan.Approved
KetobemidoneThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Ketobemidone.Approved, Investigational
KetoconazoleThe metabolism of Dextromethorphan can be decreased when combined with Ketoconazole.Approved, Investigational
L-TryptophanThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with L-Tryptophan.Approved, Nutraceutical, Withdrawn
LacosamideThe risk or severity of adverse effects can be increased when Lacosamide is combined with Dextromethorphan.Approved
LamotrigineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Dextromethorphan.Approved, Investigational
LanicemineThe risk or severity of adverse effects can be increased when Lanicemine is combined with Dextromethorphan.Investigational
LasmiditanThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Lasmiditan.Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Levetiracetam is combined with Dextromethorphan.Approved, Investigational
LevocabastineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Levocabastine.Approved, Investigational
LevocetirizineThe risk or severity of adverse effects can be increased when Levocetirizine is combined with Dextromethorphan.Approved
LevodopaThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Levodopa.Approved
Levomethadyl acetateThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Levomethadyl Acetate.Approved, Investigational
LevomilnacipranLevomilnacipran may increase the serotonergic activities of Dextromethorphan.Approved, Investigational
LevorphanolThe risk or severity of serotonin syndrome can be increased when Levorphanol is combined with Dextromethorphan.Approved
LincomycinThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Lincomycin.Approved, Vet Approved
LinezolidThe risk or severity of serotonin syndrome can be increased when Linezolid is combined with Dextromethorphan.Approved, Investigational
LisdexamfetamineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Lisdexamfetamine.Approved, Investigational
LisurideThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Lisuride.Approved, Investigational
Lithium carbonateThe risk or severity of adverse effects can be increased when Lithium carbonate is combined with Dextromethorphan.Approved
Lithium cationThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Lithium cation.Experimental
LofentanilThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Lofentanil.Illicit
LofepramineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Lofepramine.Experimental
LofexidineThe therapeutic efficacy of Dextromethorphan can be increased when used in combination with Lofexidine.Approved, Investigational
LopinavirThe metabolism of Dextromethorphan can be decreased when combined with Lopinavir.Approved
LoprazolamThe risk or severity of adverse effects can be increased when Loprazolam is combined with Dextromethorphan.Experimental
LoratadineThe risk or severity of adverse effects can be increased when Loratadine is combined with Dextromethorphan.Approved, Investigational
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Dextromethorphan.Approved
LorcaserinThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Lorcaserin.Approved
LormetazepamThe risk or severity of adverse effects can be increased when Lormetazepam is combined with Dextromethorphan.Approved
LorpiprazoleThe serum concentration of Dextromethorphan can be increased when it is combined with Lorpiprazole.Approved
LortalamineThe risk or severity of adverse effects can be increased when Lortalamine is combined with Dextromethorphan.Experimental
LovastatinThe metabolism of Dextromethorphan can be decreased when combined with Lovastatin.Approved, Investigational
LoxapineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Loxapine.Approved
LuliconazoleThe serum concentration of Dextromethorphan can be increased when it is combined with Luliconazole.Approved
LumacaftorThe metabolism of Dextromethorphan can be increased when combined with Lumacaftor.Approved
LumateperoneThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Lumateperone.Investigational
LumefantrineThe metabolism of Dextromethorphan can be decreased when combined with Lumefantrine.Approved
LurasidoneThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Lurasidone.Approved, Investigational
LymecyclineThe risk or severity of adverse effects can be increased when Lymecycline is combined with Dextromethorphan.Approved, Investigational
Lysergic Acid DiethylamideThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Lysergic Acid Diethylamide.Illicit, Investigational, Withdrawn
m-ChlorophenylpiperazineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with m-Chlorophenylpiperazine.Investigational
Magnesium acetateThe risk or severity of adverse effects can be increased when Magnesium acetate is combined with Dextromethorphan.Approved
Magnesium acetate tetrahydrateThe risk or severity of adverse effects can be increased when Magnesium acetate tetrahydrate is combined with Dextromethorphan.Approved
Magnesium Aluminum SilicateThe risk or severity of adverse effects can be increased when Magnesium Aluminum Silicate is combined with Dextromethorphan.Approved
Magnesium aspartateThe risk or severity of adverse effects can be increased when Magnesium aspartate is combined with Dextromethorphan.Experimental
Magnesium carbonateThe risk or severity of adverse effects can be increased when Magnesium carbonate is combined with Dextromethorphan.Approved, Investigational
Magnesium cationThe risk or severity of adverse effects can be increased when Magnesium cation is combined with Dextromethorphan.Approved, Nutraceutical
Magnesium chlorideThe risk or severity of adverse effects can be increased when Magnesium chloride is combined with Dextromethorphan.Approved
Magnesium citrateThe risk or severity of adverse effects can be increased when Magnesium citrate is combined with Dextromethorphan.Approved
Magnesium gluconateThe risk or severity of adverse effects can be increased when Magnesium gluconate is combined with Dextromethorphan.Approved, Investigational
Magnesium glycinateThe risk or severity of adverse effects can be increased when Magnesium glycinate is combined with Dextromethorphan.Approved
Magnesium hydroxideThe risk or severity of adverse effects can be increased when Magnesium hydroxide is combined with Dextromethorphan.Approved, Investigational
Magnesium orotateThe risk or severity of adverse effects can be increased when Magnesium orotate is combined with Dextromethorphan.Experimental
Magnesium oxideThe risk or severity of adverse effects can be increased when Magnesium oxide is combined with Dextromethorphan.Approved
Magnesium phosphateThe risk or severity of adverse effects can be increased when Magnesium phosphate is combined with Dextromethorphan.Experimental
Magnesium silicateThe risk or severity of adverse effects can be increased when Magnesium silicate is combined with Dextromethorphan.Approved
Magnesium stearateThe risk or severity of adverse effects can be increased when Magnesium stearate is combined with Dextromethorphan.Investigational
Magnesium sulfateThe therapeutic efficacy of Dextromethorphan can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
Magnesium TrisilicateThe risk or severity of adverse effects can be increased when Magnesium Trisilicate is combined with Dextromethorphan.Approved
MalathionThe therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Malathion.Approved, Investigational
ManidipineThe metabolism of Dextromethorphan can be decreased when combined with Manidipine.Approved, Investigational
MaprotilineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Maprotiline.Approved, Investigational
MazaticolThe risk or severity of adverse effects can be increased when Mazaticol is combined with Dextromethorphan.Experimental
MazindolThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Mazindol.Approved, Investigational
MebanazineThe risk or severity of serotonin syndrome can be increased when Mebanazine is combined with Dextromethorphan.Withdrawn
MebeverineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Mebeverine.Approved, Investigational
MebicarThe risk or severity of adverse effects can be increased when Mebicar is combined with Dextromethorphan.Experimental
MebutamateThe risk or severity of adverse effects can be increased when Mebutamate is combined with Dextromethorphan.Approved
MecamylamineThe risk or severity of adverse effects can be increased when Mecamylamine is combined with Dextromethorphan.Approved, Investigational
MeclizineThe risk or severity of adverse effects can be increased when Meclizine is combined with Dextromethorphan.Approved
MedazepamThe risk or severity of adverse effects can be increased when Medazepam is combined with Dextromethorphan.Experimental
MedetomidineThe risk or severity of adverse effects can be increased when Medetomidine is combined with Dextromethorphan.Vet Approved
MedifoxamineThe risk or severity of adverse effects can be increased when Medifoxamine is combined with Dextromethorphan.Experimental
Medroxyprogesterone acetateThe metabolism of Dextromethorphan can be increased when combined with Medroxyprogesterone acetate.Approved, Investigational
MefloquineThe therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Mefloquine.Approved, Investigational
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Dextromethorphan.Approved, Nutraceutical, Vet Approved
MelitracenThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Melitracen.Experimental, Investigational
MelperoneThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Melperone.Approved, Investigational
MemantineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Memantine.Approved, Investigational
MepenzolateThe risk or severity of adverse effects can be increased when Mepenzolate is combined with Dextromethorphan.Approved
MephedroneThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Mephedrone.Investigational
MephenesinThe risk or severity of adverse effects can be increased when Mephenesin is combined with Dextromethorphan.Approved
MephenoxaloneThe risk or severity of adverse effects can be increased when Mephenoxalone is combined with Dextromethorphan.Experimental
MephentermineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Mephentermine.Approved
MephenytoinThe risk or severity of adverse effects can be increased when Mephenytoin is combined with Dextromethorphan.Approved, Investigational, Withdrawn
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Dextromethorphan.Approved, Illicit
MeptazinolThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Meptazinol.Experimental
MesoridazineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Mesoridazine.Approved, Investigational
MetaxaloneThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Metaxalone.Approved
MetergolineThe risk or severity of adverse effects can be increased when Metergoline is combined with Dextromethorphan.Experimental
MethacyclineThe risk or severity of adverse effects can be increased when Methacycline is combined with Dextromethorphan.Approved, Investigational
MethadoneThe risk or severity of serotonin syndrome can be increased when Methadone is combined with Dextromethorphan.Approved
Methadyl acetateThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Methadyl Acetate.Approved, Illicit
MethamphetamineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Methamphetamine.Approved, Illicit
Methanesulfonyl FluorideThe therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Methanesulfonyl Fluoride.Investigational
MethanthelineThe risk or severity of adverse effects can be increased when Methantheline is combined with Dextromethorphan.Approved, Investigational
MethapyrileneThe risk or severity of adverse effects can be increased when Methapyrilene is combined with Dextromethorphan.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Dextromethorphan.Illicit, Withdrawn
MetharbitalThe risk or severity of adverse effects can be increased when Metharbital is combined with Dextromethorphan.Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Methocarbamol is combined with Dextromethorphan.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Dextromethorphan.Approved
MethotrexateThe serum concentration of Dextromethorphan can be decreased when it is combined with Methotrexate.Approved
MethotrimeprazineDextromethorphan may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved, Investigational
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Dextromethorphan.Approved, Investigational, Vet Approved
MethoxyphenamineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Methoxyphenamine.Experimental
MethscopolamineThe risk or severity of adverse effects can be increased when Methscopolamine is combined with Dextromethorphan.Approved
MethsuximideThe risk or severity of adverse effects can be increased when Methsuximide is combined with Dextromethorphan.Approved
MethyclothiazideThe serum concentration of Methyclothiazide can be increased when it is combined with Dextromethorphan.Approved
Methylene blueThe risk or severity of serotonin syndrome can be increased when Methylene blue is combined with Dextromethorphan.Approved, Investigational
MethylpentynolThe risk or severity of adverse effects can be increased when Methylpentynol is combined with Dextromethorphan.Experimental
MethylphenidateThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Methylphenidate.Approved, Investigational
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Dextromethorphan.Approved
Methylscopolamine bromideThe risk or severity of adverse effects can be increased when Methylscopolamine bromide is combined with Dextromethorphan.Approved
MethylthioniniumThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Methylthioninium.Experimental, Investigational
MethyprylonThe risk or severity of adverse effects can be increased when Methyprylon is combined with Dextromethorphan.Approved, Illicit, Withdrawn
MethysergideThe risk or severity of adverse effects can be increased when Methysergide is combined with Dextromethorphan.Approved
MetixeneThe risk or severity of adverse effects can be increased when Metixene is combined with Dextromethorphan.Approved
MetoclopramideThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Metoclopramide.Approved, Investigational
MetocurineThe risk or severity of adverse effects can be increased when Metocurine is combined with Dextromethorphan.Approved
Metocurine IodideThe risk or severity of adverse effects can be increased when Metocurine Iodide is combined with Dextromethorphan.Approved, Withdrawn
MetolazoneThe serum concentration of Metolazone can be increased when it is combined with Dextromethorphan.Approved
MetyrosineDextromethorphan may increase the sedative activities of Metyrosine.Approved
MianserinThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Mianserin.Approved, Investigational
MibefradilThe metabolism of Dextromethorphan can be decreased when combined with Mibefradil.Investigational, Withdrawn
MiconazoleThe metabolism of Dextromethorphan can be decreased when combined with Miconazole.Approved, Investigational, Vet Approved
MicronomicinThe risk or severity of adverse effects can be increased when Micronomicin is combined with Dextromethorphan.Experimental
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Dextromethorphan.Approved, Illicit
MidomafetamineThe risk or severity of serotonin syndrome can be increased when Midomafetamine is combined with Dextromethorphan.Experimental, Illicit, Investigational
MifepristoneThe serum concentration of Dextromethorphan can be increased when it is combined with Mifepristone.Approved, Investigational
MilnacipranMilnacipran may increase the serotonergic activities of Dextromethorphan.Approved, Investigational
MinaprineThe risk or severity of serotonin syndrome can be increased when Minaprine is combined with Dextromethorphan.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Dextromethorphan.Approved, Investigational
MirabegronThe metabolism of Dextromethorphan can be decreased when combined with Mirabegron.Approved
MirtazapineDextromethorphan may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MitotaneThe serum concentration of Dextromethorphan can be decreased when it is combined with Mitotane.Approved
MivacuriumThe risk or severity of adverse effects can be increased when Mivacurium is combined with Dextromethorphan.Approved
MK-212The risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with MK-212.Investigational
MMDAThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with MMDA.Experimental, Illicit
MoclobemideThe risk or severity of serotonin syndrome can be increased when Moclobemide is combined with Dextromethorphan.Approved, Investigational
ModafinilThe serum concentration of Dextromethorphan can be decreased when it is combined with Modafinil.Approved, Investigational
MolindoneThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Molindone.Approved
MoperoneThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Moperone.Experimental
MoricizineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Moricizine.Approved, Investigational, Withdrawn
MorphineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Morphine.Approved, Investigational
MosapramineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Mosapramine.Experimental
MosaprideThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Mosapride.Investigational
MRK-409The risk or severity of adverse effects can be increased when MRK-409 is combined with Dextromethorphan.Experimental
N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine.Experimental
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Dextromethorphan.Approved, Investigational
NafcillinThe serum concentration of Dextromethorphan can be decreased when it is combined with Nafcillin.Approved, Investigational
NaftidrofurylThe risk or severity of adverse effects can be increased when Naftidrofuryl is combined with Dextromethorphan.Experimental
NalbuphineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Nalbuphine.Approved
NaloxoneThe metabolism of Dextromethorphan can be decreased when combined with Naloxone.Approved, Vet Approved
NaltrexoneThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Naltrexone.Approved, Investigational, Vet Approved
NaluzotanThe risk or severity of adverse effects can be increased when Naluzotan is combined with Dextromethorphan.Investigational
NaratriptanThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Naratriptan.Approved, Investigational
NaronaprideThe risk or severity of adverse effects can be increased when Naronapride is combined with Dextromethorphan.Investigational
NeamineThe risk or severity of adverse effects can be increased when Neamine is combined with Dextromethorphan.Experimental
NefazodoneNefazodone may increase the serotonergic activities of Dextromethorphan.Approved, Withdrawn
NefiracetamThe risk or severity of adverse effects can be increased when Nefiracetam is combined with Dextromethorphan.Investigational
NelfinavirThe metabolism of Dextromethorphan can be decreased when combined with Nelfinavir.Approved
NeocitrullamonThe risk or severity of adverse effects can be increased when Neocitrullamon is combined with Dextromethorphan.Experimental
NeomycinThe risk or severity of adverse effects can be increased when Neomycin is combined with Dextromethorphan.Approved, Vet Approved
NeosaxitoxinThe risk or severity of adverse effects can be increased when Neosaxitoxin is combined with Dextromethorphan.Investigational
NeostigmineThe therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Neostigmine.Approved, Vet Approved
NetilmicinThe risk or severity of adverse effects can be increased when Netilmicin is combined with Dextromethorphan.Approved, Investigational
NetupitantThe serum concentration of Dextromethorphan can be increased when it is combined with Netupitant.Approved, Investigational
NevirapineThe metabolism of Dextromethorphan can be increased when combined with Nevirapine.Approved
NialamideThe risk or severity of serotonin syndrome can be increased when Nialamide is combined with Dextromethorphan.Withdrawn
NiaprazineThe risk or severity of adverse effects can be increased when Niaprazine is combined with Dextromethorphan.Experimental
NicardipineThe risk or severity of adverse effects can be increased when Nicardipine is combined with Dextromethorphan.Approved, Investigational
NicomorphineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Nicomorphine.Experimental
NilotinibThe metabolism of Dextromethorphan can be decreased when combined with Nilotinib.Approved, Investigational
NisoxetineThe risk or severity of adverse effects can be increased when Nisoxetine is combined with Dextromethorphan.Experimental
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Dextromethorphan.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Dextromethorphan.Approved, Vet Approved
NomifensineThe risk or severity of adverse effects can be increased when Nomifensine is combined with Dextromethorphan.Withdrawn
NordazepamThe risk or severity of adverse effects can be increased when Nordazepam is combined with Dextromethorphan.Approved
NorgestimateThe metabolism of Dextromethorphan can be increased when combined with Norgestimate.Approved, Investigational
NormethadoneThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Normethadone.Approved, Illicit
NortriptylineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Nortriptyline.Approved
NutmegThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Nutmeg.Approved
OctamoxinThe risk or severity of serotonin syndrome can be increased when Octamoxin is combined with Dextromethorphan.Withdrawn
OctreotideThe metabolism of Dextromethorphan can be decreased when combined with Octreotide.Approved, Investigational
OlanzapineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Olanzapine.Approved, Investigational
OlaparibThe metabolism of Dextromethorphan can be decreased when combined with Olaparib.Approved
OlopatadineThe risk or severity of adverse effects can be increased when Olopatadine is combined with Dextromethorphan.Approved
OndansetronThe risk or severity of serotonin syndrome can be increased when Ondansetron is combined with Dextromethorphan.Approved
OpipramolThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Opipramol.Investigational
OpiumThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Opium.Approved, Illicit
OrphenadrineDextromethorphan may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OrvepitantThe risk or severity of adverse effects can be increased when Orvepitant is combined with Dextromethorphan.Investigational
OsanetantThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Osanetant.Investigational
OsimertinibThe serum concentration of Dextromethorphan can be increased when it is combined with Osimertinib.Approved
OtiloniumThe risk or severity of adverse effects can be increased when Otilonium is combined with Dextromethorphan.Experimental, Investigational
OxaflozaneThe risk or severity of adverse effects can be increased when Oxaflozane is combined with Dextromethorphan.Experimental
OxaprotilineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Oxaprotiline.Experimental
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Dextromethorphan.Approved
OxcarbazepineThe risk or severity of adverse effects can be increased when Oxcarbazepine is combined with Dextromethorphan.Approved
OxiracetamThe risk or severity of adverse effects can be increased when Oxiracetam is combined with Dextromethorphan.Experimental
OxitriptanThe risk or severity of adverse effects can be increased when Oxitriptan is combined with Dextromethorphan.Approved, Investigational, Nutraceutical
OxitropiumThe risk or severity of adverse effects can be increased when Oxitropium is combined with Dextromethorphan.Investigational
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Dextromethorphan.Approved
OxybutyninThe risk or severity of adverse effects can be increased when Oxybutynin is combined with Dextromethorphan.Approved, Investigational
OxycodoneThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Oxymorphone.Approved, Investigational, Vet Approved
OxypertineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Oxypertine.Experimental
OxyphencyclimineThe risk or severity of adverse effects can be increased when Oxyphencyclimine is combined with Dextromethorphan.Approved
OxyphenoniumThe risk or severity of adverse effects can be increased when Oxyphenonium is combined with Dextromethorphan.Approved
OxytetracyclineThe risk or severity of adverse effects can be increased when Oxytetracycline is combined with Dextromethorphan.Approved, Investigational, Vet Approved
PalbociclibThe serum concentration of Dextromethorphan can be increased when it is combined with Palbociclib.Approved, Investigational
PaliperidoneThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Paliperidone.Approved
PalonosetronThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Palonosetron.Approved, Investigational
PancuroniumThe risk or severity of adverse effects can be increased when Pancuronium is combined with Dextromethorphan.Approved
PanobinostatThe serum concentration of Dextromethorphan can be increased when it is combined with Panobinostat.Approved, Investigational
ParaldehydeDextromethorphan may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
ParamethadioneThe risk or severity of adverse effects can be increased when Paramethadione is combined with Dextromethorphan.Approved
ParaoxonThe therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Paraoxon.Experimental
ParecoxibThe serum concentration of Dextromethorphan can be increased when it is combined with Parecoxib.Approved
PargylineThe risk or severity of serotonin syndrome can be increased when Pargyline is combined with Dextromethorphan.Approved
ParomomycinThe risk or severity of adverse effects can be increased when Paromomycin is combined with Dextromethorphan.Approved, Investigational
ParoxetineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Paroxetine.Approved, Investigational
Peginterferon alfa-2bThe serum concentration of Dextromethorphan can be decreased when it is combined with Peginterferon alfa-2b.Approved
PegvisomantThe metabolism of Dextromethorphan can be increased when combined with Pegvisomant.Approved
PenbutololThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Penbutolol.Approved, Investigational
PenfluridolThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Penfluridol.Experimental
PenimepicyclineThe risk or severity of adverse effects can be increased when Penimepicycline is combined with Dextromethorphan.Experimental
PentazocineThe risk or severity of serotonin syndrome can be increased when Pentazocine is combined with Dextromethorphan.Approved, Vet Approved
PenthienateThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Penthienate.Experimental
PentobarbitalThe metabolism of Dextromethorphan can be increased when combined with Pentobarbital.Approved, Investigational, Vet Approved
PentoliniumThe risk or severity of adverse effects can be increased when Pentolinium is combined with Dextromethorphan.Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Dextromethorphan.Approved
PerazineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Perazine.Approved, Investigational
PergolideThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Pergolide.Approved, Investigational, Vet Approved, Withdrawn
PerospironeThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Perospirone.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Perphenazine.Approved
PethidineThe risk or severity of serotonin syndrome can be increased when Pethidine is combined with Dextromethorphan.Approved
PhenacemideThe risk or severity of adverse effects can be increased when Phenacemide is combined with Dextromethorphan.Approved
PhenazocineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Phenazocine.Experimental
PhencyclidineThe risk or severity of adverse effects can be increased when Phencyclidine is combined with Dextromethorphan.Illicit
PhenelzineThe risk or severity of serotonin syndrome can be increased when Phenelzine is combined with Dextromethorphan.Approved
PhenethylamineThe risk or severity of adverse effects can be increased when Phenethylamine is combined with Dextromethorphan.Experimental
PheneturideThe risk or severity of adverse effects can be increased when Pheneturide is combined with Dextromethorphan.Experimental
PhenglutarimideThe risk or severity of adverse effects can be increased when Phenglutarimide is combined with Dextromethorphan.Experimental
PhenibutThe risk or severity of adverse effects can be increased when Phenibut is combined with Dextromethorphan.Experimental
PheniprazineThe risk or severity of serotonin syndrome can be increased when Pheniprazine is combined with Dextromethorphan.Withdrawn
PhenobarbitalThe metabolism of Dextromethorphan can be increased when combined with Phenobarbital.Approved, Investigational
PhenoperidineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Phenoperidine.Experimental
PhenoxypropazineThe risk or severity of serotonin syndrome can be increased when Phenoxypropazine is combined with Dextromethorphan.Withdrawn
PhenprobamateThe risk or severity of adverse effects can be increased when Phenprobamate is combined with Dextromethorphan.Experimental
PhensuximideThe risk or severity of adverse effects can be increased when Phensuximide is combined with Dextromethorphan.Approved
PhentermineThe risk or severity of serotonin syndrome can be increased when Phentermine is combined with Dextromethorphan.Approved, Illicit
Phenylbutyric acidThe metabolism of Dextromethorphan can be decreased when combined with Phenylbutyric acid.Approved, Investigational
PhenytoinThe metabolism of Dextromethorphan can be increased when combined with Phenytoin.Approved, Vet Approved
PhysostigmineThe therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Physostigmine.Approved, Investigational
PiclozotanThe risk or severity of adverse effects can be increased when Piclozotan is combined with Dextromethorphan.Investigational
PimavanserinThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Pimavanserin.Approved, Investigational
PimozideThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Pimozide.Approved
PinazepamThe risk or severity of adverse effects can be increased when Pinazepam is combined with Dextromethorphan.Experimental
PindololThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Pindolol.Approved, Investigational
PipamperoneThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Pipamperone.Approved, Investigational
PipecuroniumThe risk or severity of adverse effects can be increased when Pipecuronium is combined with Dextromethorphan.Approved
PipenzolateThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Pipenzolate.Experimental
PiperidolateThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Piperidolate.Experimental
PipotiazineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Pipotiazine.Approved, Investigational
PirenzepineThe risk or severity of adverse effects can be increased when Pirenzepine is combined with Dextromethorphan.Approved
PiritramideThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Piritramide.Approved, Investigational
PirlimycinThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Pirlimycin.Vet Approved
PirlindoleThe risk or severity of serotonin syndrome can be increased when Pirlindole is combined with Dextromethorphan.Approved
PitolisantThe serum concentration of Dextromethorphan can be decreased when it is combined with Pitolisant.Approved, Investigational
PivagabineThe risk or severity of adverse effects can be increased when Pivagabine is combined with Dextromethorphan.Investigational
PivhydrazineThe risk or severity of serotonin syndrome can be increased when Pivhydrazine is combined with Dextromethorphan.Withdrawn
PizotifenThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Pizotifen.Approved
PlazomicinThe risk or severity of adverse effects can be increased when Plazomicin is combined with Dextromethorphan.Approved, Investigational
PoldineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Poldine.Experimental
Polymyxin B SulfateThe risk or severity of adverse effects can be increased when Polymyxin B Sulfate is combined with Dextromethorphan.Approved, Vet Approved
PolythiazideThe serum concentration of Polythiazide can be increased when it is combined with Dextromethorphan.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Pomalidomide is combined with Dextromethorphan.Approved
PosaconazoleThe metabolism of Dextromethorphan can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PramipexoleDextromethorphan may increase the sedative activities of Pramipexole.Approved, Investigational
PravastatinThe metabolism of Dextromethorphan can be decreased when combined with Pravastatin.Approved
PrazepamThe risk or severity of adverse effects can be increased when Prazepam is combined with Dextromethorphan.Approved, Illicit
PregabalinThe therapeutic efficacy of Dextromethorphan can be increased when used in combination with Pregabalin.Approved, Illicit, Investigational
PridinolThe risk or severity of adverse effects can be increased when Pridinol is combined with Dextromethorphan.Experimental
PrifiniumThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Prifinium.Experimental
PrimidoneThe metabolism of Dextromethorphan can be increased when combined with Primidone.Approved, Vet Approved
ProcainamideThe risk or severity of adverse effects can be increased when Procainamide is combined with Dextromethorphan.Approved
ProcaineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Procaine.Approved, Investigational, Vet Approved
ProcarbazineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Procarbazine.Approved, Investigational
ProchlorperazineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Prochlorperazine.Approved, Vet Approved
ProcyclidineThe risk or severity of adverse effects can be increased when Procyclidine is combined with Dextromethorphan.Approved
ProgabideThe risk or severity of adverse effects can be increased when Progabide is combined with Dextromethorphan.Approved, Investigational
PromazineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Promazine.Approved, Vet Approved
PromethazineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Promethazine.Approved, Investigational
PropafenoneThe metabolism of Dextromethorphan can be decreased when combined with Propafenone.Approved
PropanididThe risk or severity of adverse effects can be increased when Propanidid is combined with Dextromethorphan.Experimental
PropanthelineThe risk or severity of adverse effects can be increased when Propantheline is combined with Dextromethorphan.Approved
PropericiazineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Propericiazine.Approved, Investigational
PropiomazineThe risk or severity of adverse effects can be increased when Propiomazine is combined with Dextromethorphan.Approved
PropiopromazineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Propiopromazine.Vet Approved
PropiverineThe risk or severity of adverse effects can be increased when Propiverine is combined with Dextromethorphan.Approved, Investigational
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Dextromethorphan.Approved, Investigational, Vet Approved
ProthipendylThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Prothipendyl.Investigational
ProtriptylineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Protriptyline.Approved
ProxibarbalThe risk or severity of adverse effects can be increased when Proxibarbal is combined with Dextromethorphan.Experimental
PRX-08066The risk or severity of adverse effects can be increased when Dextromethorphan is combined with PRX-08066.Investigational
PseudoephedrineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Pseudoephedrine.Approved
PsilocybineThe risk or severity of adverse effects can be increased when Psilocybine is combined with Dextromethorphan.Investigational
PuromycinThe risk or severity of adverse effects can be increased when Puromycin is combined with Dextromethorphan.Experimental
PyrantelThe risk or severity of adverse effects can be increased when Pyrantel is combined with Dextromethorphan.Approved, Vet Approved
PyridostigmineThe therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Pyridostigmine.Approved, Investigational
PyrithyldioneThe risk or severity of adverse effects can be increased when Pyrithyldione is combined with Dextromethorphan.Experimental
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Dextromethorphan.Approved, Illicit
QuetiapineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Quetiapine.Approved
QuinethazoneThe serum concentration of Quinethazone can be increased when it is combined with Dextromethorphan.Approved
QuinidineThe serum concentration of Dextromethorphan can be increased when it is combined with Quinidine.Approved, Investigational
QuinineThe metabolism of Dextromethorphan can be increased when combined with Quinine.Approved
QuinupramineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Quinupramine.Experimental
RacloprideThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Ramelteon is combined with Dextromethorphan.Approved, Investigational
RamosetronThe risk or severity of adverse effects can be increased when Ramosetron is combined with Dextromethorphan.Approved, Investigational
RapacuroniumThe risk or severity of adverse effects can be increased when Rapacuronium is combined with Dextromethorphan.Approved, Withdrawn
RasagilineThe risk or severity of serotonin syndrome can be increased when Rasagiline is combined with Dextromethorphan.Approved
ReboxetineThe risk or severity of adverse effects can be increased when Reboxetine is combined with Dextromethorphan.Approved, Investigational
RemacemideThe risk or severity of adverse effects can be increased when Remacemide is combined with Dextromethorphan.Investigational
RemifentanilThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Remifentanil.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Remoxipride.Approved, Withdrawn
RenzaprideThe risk or severity of adverse effects can be increased when Renzapride is combined with Dextromethorphan.Investigational
RepinotanThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Repinotan.Investigational
ReposalThe risk or severity of adverse effects can be increased when Reposal is combined with Dextromethorphan.Approved
ReserpineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Reserpine.Approved, Investigational
RevefenacinThe risk or severity of adverse effects can be increased when Revefenacin is combined with Dextromethorphan.Investigational
RheinThe metabolism of Dextromethorphan can be decreased when combined with Rhein.Experimental
RibostamycinThe risk or severity of adverse effects can be increased when Ribostamycin is combined with Dextromethorphan.Approved, Investigational
RifampicinThe metabolism of Dextromethorphan can be increased when combined with Rifampicin.Approved
RifamycinThe metabolism of Dextromethorphan can be increased when combined with Rifamycin.Investigational
RifapentineThe metabolism of Dextromethorphan can be increased when combined with Rifapentine.Approved, Investigational
RifaximinThe metabolism of Dextromethorphan can be increased when combined with Rifaximin.Approved, Investigational
RiluzoleThe risk or severity of adverse effects can be increased when Riluzole is combined with Dextromethorphan.Approved, Investigational
RimexoloneThe metabolism of Dextromethorphan can be increased when combined with Rimexolone.Approved
RisperidoneThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Risperidone.Approved, Investigational
RitanserinRitanserin may increase the serotonergic activities of Dextromethorphan.Investigational
RitobegronThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Ritobegron.Investigational
RitonavirThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Ritonavir.Approved, Investigational
RivastigmineThe therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Rivastigmine.Approved, Investigational
RizatriptanThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Rizatriptan.Approved
RociverineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Rociverine.Experimental
RocuroniumThe risk or severity of adverse effects can be increased when Rocuronium is combined with Dextromethorphan.Approved
RolapitantThe metabolism of Dextromethorphan can be decreased when combined with Rolapitant.Approved, Investigational
RolipramThe risk or severity of adverse effects can be increased when Rolipram is combined with Dextromethorphan.Investigational
RolitetracyclineThe risk or severity of adverse effects can be increased when Rolitetracycline is combined with Dextromethorphan.Approved
RomifidineThe risk or severity of adverse effects can be increased when Romifidine is combined with Dextromethorphan.Vet Approved
RopiniroleDextromethorphan may increase the sedative activities of Ropinirole.Approved, Investigational
RotigotineDextromethorphan may increase the sedative activities of Rotigotine.Approved
RP-5063The risk or severity of adverse effects can be increased when Dextromethorphan is combined with RP-5063.Investigational
RucaparibThe metabolism of Dextromethorphan can be decreased when combined with Rucaparib.Approved, Investigational
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Dextromethorphan.Approved
SafinamideThe risk or severity of serotonin syndrome can be increased when Safinamide is combined with Dextromethorphan.Approved, Investigational
SafrazineThe risk or severity of serotonin syndrome can be increased when Safrazine is combined with Dextromethorphan.Withdrawn
SaquinavirThe metabolism of Dextromethorphan can be decreased when combined with Saquinavir.Approved, Investigational
SaredutantThe risk or severity of adverse effects can be increased when Saredutant is combined with Dextromethorphan.Investigational
SarilumabThe therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Sarilumab.Approved, Investigational
SarpogrelateThe risk or severity of adverse effects can be increased when Sarpogrelate is combined with Dextromethorphan.Investigational
ScopolamineThe risk or severity of adverse effects can be increased when Scopolamine is combined with Dextromethorphan.Approved, Investigational
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Dextromethorphan.Approved, Vet Approved
Secretin humanThe therapeutic efficacy of Secretin human can be decreased when used in combination with Dextromethorphan.Approved
Secretin porcineThe therapeutic efficacy of Secretin porcine can be decreased when used in combination with Dextromethorphan.Approved
SelegilineThe risk or severity of serotonin syndrome can be increased when Selegiline is combined with Dextromethorphan.Approved, Investigational, Vet Approved
SerotoninThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Serotonin.Investigational, Nutraceutical
SertindoleThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Sertindole.Approved, Investigational, Withdrawn
SertralineSertraline may increase the serotonergic activities of Dextromethorphan.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Dextromethorphan.Approved, Vet Approved
SibutramineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Sibutramine.Approved, Illicit, Investigational, Withdrawn
SildenafilThe metabolism of Sildenafil can be decreased when combined with Dextromethorphan.Approved, Investigational
SiltuximabThe serum concentration of Dextromethorphan can be decreased when it is combined with Siltuximab.Approved, Investigational
SimeprevirThe serum concentration of Dextromethorphan can be increased when it is combined with Simeprevir.Approved
SisomicinThe risk or severity of adverse effects can be increased when Sisomicin is combined with Dextromethorphan.Investigational
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Dextromethorphan.Approved
SolifenacinThe risk or severity of adverse effects can be increased when Solifenacin is combined with Dextromethorphan.Approved
St. John's WortThe serum concentration of Dextromethorphan can be decreased when it is combined with St. John's Wort.Approved, Investigational, Nutraceutical
StiripentolThe serum concentration of Dextromethorphan can be increased when it is combined with Stiripentol.Approved
StreptomycinThe risk or severity of adverse effects can be increased when Streptomycin is combined with Dextromethorphan.Approved, Vet Approved
StyramateThe risk or severity of adverse effects can be increased when Styramate is combined with Dextromethorphan.Experimental
SuccinylcholineThe risk or severity of adverse effects can be increased when Succinylcholine is combined with Dextromethorphan.Approved
SufentanilThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Sufentanil.Approved, Investigational
SulconazoleThe metabolism of Dextromethorphan can be decreased when combined with Sulconazole.Approved
SulpirideThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Sulpiride.Approved, Investigational
SulthiameThe risk or severity of adverse effects can be increased when Sulthiame is combined with Dextromethorphan.Experimental
SultoprideThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Sultopride.Experimental
SumatriptanThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Sumatriptan.Approved, Investigational
SuvorexantDextromethorphan may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved, Investigational
TacrineThe therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Tacrine.Approved, Investigational, Withdrawn
TalbutalThe risk or severity of adverse effects can be increased when Talbutal is combined with Dextromethorphan.Approved, Illicit
TalopramThe risk or severity of adverse effects can be increased when Talopram is combined with Dextromethorphan.Experimental
TandospironeThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Dextromethorphan.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Tasimelteon is combined with Dextromethorphan.Approved, Investigational
TD-8954The risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with TD-8954.Investigational
Tedizolid phosphateTedizolid phosphate may increase the serotonergic activities of Dextromethorphan.Approved
TegaserodThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Tegaserod.Approved, Investigational, Withdrawn
TelaprevirThe metabolism of Dextromethorphan can be decreased when combined with Telaprevir.Approved, Withdrawn
TelithromycinThe metabolism of Dextromethorphan can be decreased when combined with Telithromycin.Approved
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Dextromethorphan.Approved, Investigational
TerbinafineThe metabolism of Dextromethorphan can be decreased when combined with Terbinafine.Approved, Investigational, Vet Approved
TerfenadineThe risk or severity of adverse effects can be increased when Terfenadine is combined with Dextromethorphan.Approved, Withdrawn
TetracyclineThe risk or severity of adverse effects can be increased when Tetracycline is combined with Dextromethorphan.Approved, Vet Approved
TetrahydrocannabivarinThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Tetrahydrocannabivarin.Investigational
TetrahydropalmatineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Tetrahydropalmatine.Investigational
TetrazepamThe risk or severity of adverse effects can be increased when Tetrazepam is combined with Dextromethorphan.Experimental
TetrodotoxinThe risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Dextromethorphan.Investigational
ThalidomideDextromethorphan may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Dextromethorphan.Approved, Vet Approved
ThiazinamThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Thiazinam.Experimental
ThiethylperazineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Thiethylperazine.Withdrawn
ThiocolchicosideThe risk or severity of adverse effects can be increased when Thiocolchicoside is combined with Dextromethorphan.Approved, Investigational
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Dextromethorphan.Approved, Vet Approved
ThiopropazateThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Thiopropazate.Experimental
ThioproperazineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Thioproperazine.Approved
ThioridazineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Thioridazine.Approved, Withdrawn
ThiothixeneThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Thiothixene.Approved
ThonzylamineThe risk or severity of adverse effects can be increased when Thonzylamine is combined with Dextromethorphan.Approved
TiagabineThe risk or severity of adverse effects can be increased when Tiagabine is combined with Dextromethorphan.Approved, Investigational
TianeptineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Tianeptine.Approved, Investigational
TiaprideThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Tiapride.Approved, Investigational
TicagrelorThe metabolism of Dextromethorphan can be decreased when combined with Ticagrelor.Approved
Tiemonium iodideThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Tiemonium iodide.Experimental
TigecyclineThe risk or severity of adverse effects can be increased when Tigecycline is combined with Dextromethorphan.Approved
TiletamineThe risk or severity of adverse effects can be increased when Tiletamine is combined with Dextromethorphan.Vet Approved
TilidineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Tilidine.Experimental
TimepidiumThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Timepidium.Experimental
TiotropiumThe risk or severity of adverse effects can be increased when Tiotropium is combined with Dextromethorphan.Approved
TipranavirThe metabolism of Dextromethorphan can be decreased when combined with Tipranavir.Approved, Investigational
TizanidineThe risk or severity of adverse effects can be increased when Tizanidine is combined with Dextromethorphan.Approved, Investigational
TobramycinThe risk or severity of adverse effects can be increased when Tobramycin is combined with Dextromethorphan.Approved, Investigational
TocilizumabThe serum concentration of Dextromethorphan can be decreased when it is combined with Tocilizumab.Approved
TofisopamThe risk or severity of adverse effects can be increased when Tofisopam is combined with Dextromethorphan.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Dextromethorphan.Approved, Withdrawn
ToloxatoneThe risk or severity of serotonin syndrome can be increased when Toloxatone is combined with Dextromethorphan.Approved
TolperisoneThe risk or severity of adverse effects can be increased when Tolperisone is combined with Dextromethorphan.Approved, Investigational
TolterodineThe risk or severity of adverse effects can be increased when Tolterodine is combined with Dextromethorphan.Approved, Investigational
TopiramateThe risk or severity of adverse effects can be increased when Topiramate is combined with Dextromethorphan.Approved
TramadolThe risk or severity of serotonin syndrome can be increased when Tramadol is combined with Dextromethorphan.Approved, Investigational
TramiprosateThe risk or severity of adverse effects can be increased when Tramiprosate is combined with Dextromethorphan.Investigational
TranylcypromineThe risk or severity of serotonin syndrome can be increased when Tranylcypromine is combined with Dextromethorphan.Approved, Investigational
TrazodoneThe risk or severity of serotonin syndrome can be increased when Trazodone is combined with Dextromethorphan.Approved, Investigational
TriamcinoloneThe metabolism of Dextromethorphan can be increased when combined with Triamcinolone.Approved, Vet Approved
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Dextromethorphan.Approved, Investigational
Tricaine methanesulfonateThe risk or severity of adverse effects can be increased when Tricaine methanesulfonate is combined with Dextromethorphan.Vet Approved
TrichlorfonThe therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Trichlorfon.Vet Approved
TrichlormethiazideThe serum concentration of Trichlormethiazide can be increased when it is combined with Dextromethorphan.Approved, Vet Approved
TrichloroethyleneThe risk or severity of adverse effects can be increased when Trichloroethylene is combined with Dextromethorphan.Approved
TriclofosThe risk or severity of adverse effects can be increased when Triclofos is combined with Dextromethorphan.Withdrawn
TridihexethylThe risk or severity of adverse effects can be increased when Tridihexethyl is combined with Dextromethorphan.Withdrawn
TrifluoperazineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Trifluoperazine.Approved, Investigational
TrifluperidolThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Trifluperidol.Experimental
TriflupromazineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Triflupromazine.Approved, Vet Approved
TrihexyphenidylThe risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Dextromethorphan.Approved
TrimebutineThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Trimebutine.Approved
TrimethadioneThe risk or severity of adverse effects can be increased when Trimethadione is combined with Dextromethorphan.Approved
TrimethaphanThe risk or severity of adverse effects can be increased when Trimethaphan is combined with Dextromethorphan.Approved, Investigational
TrimipramineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Triprolidine is combined with Dextromethorphan.Approved
TroleandomycinThe metabolism of Dextromethorphan can be decreased when combined with Troleandomycin.Approved
TropatepineThe risk or severity of adverse effects can be increased when Tropatepine is combined with Dextromethorphan.Experimental
TropicamideThe risk or severity of adverse effects can be increased when Tropicamide is combined with Dextromethorphan.Approved, Investigational
TropisetronThe risk or severity of adverse effects can be increased when Tropisetron is combined with Dextromethorphan.Approved, Investigational
TrospiumThe risk or severity of adverse effects can be increased when Trospium is combined with Dextromethorphan.Approved
TubocurarineThe therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Tubocurarine.Approved
TyrothricinThe therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Tyrothricin.Approved
UmeclidiniumThe risk or severity of adverse effects can be increased when Umeclidinium is combined with Dextromethorphan.Approved
UrapidilThe risk or severity of adverse effects can be increased when Urapidil is combined with Dextromethorphan.Investigational
VabicaserinThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Vabicaserin.Investigational
ValerianThe risk or severity of adverse effects can be increased when Valerian is combined with Dextromethorphan.Approved, Experimental, Investigational
ValnoctamideThe risk or severity of adverse effects can be increased when Valnoctamide is combined with Dextromethorphan.Investigational
Valproate bismuthThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Valproate bismuth.Approved
Valproic AcidThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Valproic Acid.Approved, Investigational
ValpromideThe risk or severity of adverse effects can be increased when Valpromide is combined with Dextromethorphan.Experimental
VancomycinThe risk or severity of adverse effects can be increased when Vancomycin is combined with Dextromethorphan.Approved
VecuroniumThe risk or severity of adverse effects can be increased when Vecuronium is combined with Dextromethorphan.Approved
VemurafenibThe serum concentration of Dextromethorphan can be increased when it is combined with Vemurafenib.Approved
VenlafaxineVenlafaxine may increase the serotonergic activities of Dextromethorphan.Approved
VeraliprideThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Veralipride.Experimental
VerapamilThe metabolism of Dextromethorphan can be decreased when combined with Verapamil.Approved
VigabatrinThe risk or severity of adverse effects can be increased when Vigabatrin is combined with Dextromethorphan.Approved
VilazodoneThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Vilazodone.Approved
ViloxazineThe risk or severity of adverse effects can be increased when Viloxazine is combined with Dextromethorphan.Approved, Investigational, Withdrawn
VinbarbitalThe risk or severity of adverse effects can be increased when Vinbarbital is combined with Dextromethorphan.Experimental
VinpocetineThe risk or severity of adverse effects can be increased when Vinpocetine is combined with Dextromethorphan.Investigational
Vinyl etherThe risk or severity of adverse effects can be increased when Vinyl ether is combined with Dextromethorphan.Experimental
VinylbitalThe risk or severity of adverse effects can be increased when Vinylbital is combined with Dextromethorphan.Experimental
VoriconazoleThe metabolism of Dextromethorphan can be decreased when combined with Voriconazole.Approved, Investigational
VortioxetineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Vortioxetine.Approved, Investigational
WortmanninThe risk or severity of adverse effects can be increased when Wortmannin is combined with Dextromethorphan.Experimental
XP19986The risk or severity of adverse effects can be increased when XP19986 is combined with Dextromethorphan.Investigational
XylazineThe risk or severity of adverse effects can be increased when Xylazine is combined with Dextromethorphan.Vet Approved
YKP-1358The risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with YKP-1358.Investigational
YohimbineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Yohimbine.Approved, Investigational, Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Dextromethorphan.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Ziconotide is combined with Dextromethorphan.Approved
ZimelidineZimelidine may increase the serotonergic activities of Dextromethorphan.Withdrawn
ZincThe therapeutic efficacy of Zinc can be decreased when used in combination with Dextromethorphan.Approved, Investigational
ZiprasidoneThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Ziprasidone.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Zolazepam is combined with Dextromethorphan.Vet Approved
ZolmitriptanThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Zolmitriptan.Approved, Investigational
ZolpidemDextromethorphan may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Zonisamide is combined with Dextromethorphan.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Dextromethorphan.Approved
ZotepineThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Zotepine.Approved, Investigational, Withdrawn
ZuclopenthixolThe risk or severity of serotonin syndrome can be increased when Dextromethorphan is combined with Zuclopenthixol.Approved, Investigational
Food Interactions
  • Take without regard to meals.

References

Synthesis Reference

Mahendra R. Patel, "Sustained Release Suspension Preparation For Dextromethorphan." U.S. Patent US20130115253, issued May 09, 2013.

US20130115253
General References
  1. Brooks BR, Thisted RA, Appel SH, Bradley WG, Olney RK, Berg JE, Pope LE, Smith RA: Treatment of pseudobulbar affect in ALS with dextromethorphan/quinidine: a randomized trial. Neurology. 2004 Oct 26;63(8):1364-70. [PubMed:15505150]
  2. Olney JW, Labruyere J, Price MT: Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science. 1989 Jun 16;244(4910):1360-2. [PubMed:2660263]
  3. Hargreaves RJ, Hill RG, Iversen LL: Neuroprotective NMDA antagonists: the controversy over their potential for adverse effects on cortical neuronal morphology. Acta Neurochir Suppl (Wien). 1994;60:15-9. [PubMed:7976530]
  4. Carliss RD, Radovsky A, Chengelis CP, O'Neill TP, Shuey DL: Oral administration of dextromethorphan does not produce neuronal vacuolation in the rat brain. Neurotoxicology. 2007 Jul;28(4):813-8. Epub 2007 Apr 6. [PubMed:17573115]
  5. Hernandez SC, Bertolino M, Xiao Y, Pringle KE, Caruso FS, Kellar KJ: Dextromethorphan and its metabolite dextrorphan block alpha3beta4 neuronal nicotinic receptors. J Pharmacol Exp Ther. 2000 Jun;293(3):962-7. [PubMed:10869398]
External Links
KEGG Drug
D03742
KEGG Compound
C06947
PubChem Compound
5360696
PubChem Substance
46506530
ChemSpider
13109865
BindingDB
50366613
ChEBI
92579
ChEMBL
CHEMBL52440
Therapeutic Targets Database
DNC000541
PharmGKB
PA449273
Drugs.com
Drugs.com Drug Page
Wikipedia
Dextromethorphan
ATC Codes
R05DA09 — DextromethorphanN07XX59 — Dextromethorphan, combinations
AHFS Codes
  • 48:08.00 — Antitussives
  • 48:16.00 — Expectorants
MSDS
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Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0Enrolling by InvitationDiagnosticAlzheimer's Disease (AD) / Mild Cognitive Impairment (MCI)1
0Not Yet RecruitingTreatmentCannabis Use Disorders1
0RecruitingDiagnosticStage IIB Esophageal Cancer / Stage IIB Esophageal Cancer AJCC v7 / Stage III Esophageal Cancer AJCC v7 / Stage IIIA Esophageal Cancer / Stage IIIA Esophageal Cancer AJCC v7 / Stage IIIB Esophageal Cancer / Stage IIIB Esophageal Cancer AJCC v7 / Stage IIIC Esophageal Cancer / Stage IIIC Esophageal Cancer AJCC v71
1Active Not RecruitingBasic ScienceNeoplasms Metastasis1
1CompletedNot AvailableHealthy Adult Volunteers / Pharmacokinetics of Dextromethorphan / Pharmacokinetics of Isavuconazole1
1CompletedNot AvailableHealthy Volunteers2
1CompletedBasic ScienceAlzheimer's Disease (AD) / Huntington's Disease (HD)1
1CompletedBasic ScienceCytomegalovirus (CMV)1
1CompletedBasic ScienceDrug Interactions1
1CompletedBasic ScienceHealthy Adult Male and Female Volunteers1
1CompletedBasic ScienceHealthy Volunteers1
1CompletedBasic ScienceHealthy Volunteers / Human Immunodeficiency Virus (HIV) Infections1
1CompletedBasic ScienceHeart Diseases1
1CompletedBasic SciencePharmacokinetics of Caffeine / Pharmacokinetics of Dextromethorphan / Prostate Cancer1
1CompletedDiagnosticDrug Interactions1
1CompletedDiagnosticHealthy Volunteers1
1CompletedDiagnosticSchizophrenic Disorders1
1CompletedHealth Services ResearchHealthy Volunteers1
1CompletedTreatmentAdult Solid Neoplasm1
1CompletedTreatmentCognitive Disorders / Healthy Volunteers1
1CompletedTreatmentCoughing / Respiratory Tract Infections (RTI)1
1CompletedTreatmentDrug Interactions1
1CompletedTreatmentExperimental Pain / Hyperalgesia1
1CompletedTreatmentHealthy Volunteers4
1CompletedTreatmentMajor Depressive Disorder (MDD)1
1CompletedTreatmentProstate Neoplasms1
1CompletedTreatmentPsoriasis1
1CompletedTreatmentRefractory Multiple Myeloma / Stage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma1
1CompletedTreatmentTumors, Solid1
1CompletedTreatmentVoice Disorders1
1RecruitingBasic ScienceHeart Diseases1
1RecruitingOtherCrohn's Disease (CD)1
1RecruitingTreatmentCholangiocarcinomas / Neoplasms, Hepatic1
1RecruitingTreatmentContiguous Stage II Adult Lymphoblastic Lymphoma / Noncontiguous Stage II Adult Lymphoblastic Lymphoma / Stage I Adult Lymphoblastic Lymphoma / Stage III Adult Lymphoblastic Lymphoma / Stage IV Adult Lymphoblastic Lymphoma / Untreated Adult Acute Lymphoblastic Leukemia1
1RecruitingTreatmentRefractory Multiple Myeloma1
1SuspendedTreatmentLight Chain Deposition Disease / Primary Systemic Amyloidosis1
1TerminatedTreatmentChildhood Atypical Teratoid/Rhabdoid Tumor / Childhood Central Nervous System Choriocarcinoma / Childhood Central Nervous System Germinoma / Childhood Central Nervous System Mixed Germ Cell Tumor / Childhood Central Nervous System Teratoma / Childhood Central Nervous System Yolk Sac Tumor / Childhood Choroid Plexus Tumor / Childhood Craniopharyngioma / Childhood Ependymoblastoma / Childhood Grade I Meningioma / Childhood Grade II Meningioma / Childhood Grade III Meningioma / Childhood Infratentorial Ependymoma / Childhood Medulloepithelioma / Childhood Mixed Glioma / Childhood Oligodendroglioma / Childhood Supratentorial Ependymoma / Gonadotroph Adenoma / Pituitary Basophilic Adenoma / Pituitary Chromophobe Adenoma / Pituitary Eosinophilic Adenoma / Prolactin Secreting Adenoma / Recurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Anaplastic Large Cell Lymphoma / Recurrent Childhood Brain Stem Glioma / Recurrent Childhood Central Nervous System Embryonal Tumor / Recurrent Childhood Cerebellar Astrocytoma / Recurrent Childhood Cerebral Astrocytoma / Recurrent Childhood Ependymoma / Recurrent Childhood Grade III Lymphomatoid Granulomatosis / Recurrent Childhood Large Cell Lymphoma / Recurrent Childhood Lymphoblastic Lymphoma / Recurrent Childhood Medulloblastoma / Recurrent Childhood Pineoblastoma / Recurrent Childhood Small Noncleaved Cell Lymphoma / Recurrent Childhood Spinal Cord Neoplasm / Recurrent Childhood Subependymal Giant Cell Astrocytoma / Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor / Recurrent Childhood Visual Pathway and Hypothalamic Glioma / Recurrent Childhood Visual Pathway Glioma / Recurrent Pituitary Tumor / Recurrent/Refractory Childhood Hodgkin Lymphoma / T-cell Childhood Acute Lymphoblastic Leukemia / T-Cell Large Granular Lymphocyte Leukemia / TSH Secreting Adenoma / Unspecified Childhood Solid Tumor, Protocol Specific1
1TerminatedTreatmentRecurrent Childhood Anaplastic Astrocytoma / Recurrent Childhood Anaplastic Oligoastrocytoma / Recurrent Childhood Anaplastic Oligodendroglioma / Recurrent Childhood Giant Cell Glioblastoma / Recurrent Childhood Glioblastoma / Recurrent Childhood Gliomatosis Cerebri / Recurrent Childhood Gliosarcoma1
1Unknown StatusTreatmentOpioid-Induced Hyperalgesia1
1WithdrawnTreatmentTraumas1
1, 2Active Not RecruitingTreatmentRecurrent Plasma Cell Myeloma / Refractory Plasma Cell Myeloma1
1, 2Active Not RecruitingTreatmentRefractory Multiple Myeloma3
1, 2CompletedTreatmentDiabetic Macular Edema (DME)1
1, 2CompletedTreatmentMultiple Myeloma (MM) / Stage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma1
1, 2Not Yet RecruitingNot AvailableSchizophrenic Disorders1
1, 2Not Yet RecruitingTreatmentCancer of the Ovary1
1, 2Not Yet RecruitingTreatmentTumors, Solid1
1, 2RecruitingTreatmentMultiple Myeloma (MM)2
1, 2RecruitingTreatmentTreatments1
1, 2TerminatedTreatmentRefractory Multiple Myeloma / Stage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma1
2Active Not RecruitingTreatmentB-cell Adult Acute Lymphoblastic Leukemia / Ph Positive Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Lymphoblastic Leukemia / T-cell Adult Acute Lymphoblastic Leukemia1
2Active Not RecruitingTreatmentDe Novo / Low-dose Corticosteroids Pretreatment / Secondary / Untreated Philadelphia Positive Acute Lymphoblastic Leukemia1
2Active Not RecruitingTreatmentExtramedullary Plasmacytoma / Isolated Plasmacytoma of Bone / Light Chain Deposition Disease / Primary Systemic Amyloidosis / Stage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma1
2Active Not RecruitingTreatmentExtranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue / Nodal Marginal Zone Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Small Lymphocytic Lymphoma / Refractory Chronic Lymphocytic Leukemia / Splenic Marginal Zone Lymphoma / Waldenström's Macroglobulinemia (WM)1
2Active Not RecruitingTreatmentMultiple Myeloma (MM)1
2Active Not RecruitingTreatmentRefractory Multiple Myeloma / Stage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma1
2Active Not RecruitingTreatmentSickle Cell Disorders1
2Active Not RecruitingTreatmentStage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma2
2CompletedDiagnosticHealthy Volunteers1
2CompletedPreventionProphylaxis of acute chemotherapy induced nausea and vomiting1
2CompletedTreatmentAcute Agitation / Alzheimer's Disease (AD)1
2CompletedTreatmentAdenocarcinoma of the Colon / Adenocarcinoma of the Rectum / Hepatic Metastases / Metastatic Colon Cancer / Recurrent Colon Cancer / Recurrent Rectal Cancer / Stage IV Rectal Cancer1
2CompletedTreatmentAdult Nasal Type Extranodal NK/T-Cell Lymphoma / Anaplastic Large Cell Lymphoma / Angioimmunoblastic T-Cell Lymphoma / Cutaneous B-Cell Non-Hodgkin Lymphoma / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Hepatosplenic T-Cell Lymphoma / Intraocular Lymphoma / Nodal marginal zone B-cell lymphomas / Noncutaneous Extranodal Lymphoma / Peripheral T-Cell Lymphoma (PTCL) / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Grade III Lymphomatoid Granulomatosis / Recurrent Adult Hodgkin's Lymphoma / Recurrent Adult Immunoblastic Large Cell Lymphoma / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Adult T-Cell Leukemia/Lymphoma / Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Mycosis Fungoides/Sezary Syndrome / Recurrent Small Lymphocytic Lymphoma / Small Intestine Lymphoma / Splenic Marginal Zone Lymphoma / Testicular Lymphoma / Waldenström's Macroglobulinemia (WM)1
2CompletedTreatmentAdult Nasal Type Extranodal NK/T-Cell Lymphoma / Anaplastic Large Cell Lymphoma / Angioimmunoblastic T-Cell Lymphoma / Cutaneous B-Cell Non-Hodgkin Lymphoma / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Intraocular Lymphoma / Nodal marginal zone B-cell lymphomas / Peripheral T-Cell Lymphoma (PTCL) / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Grade III Lymphomatoid Granulomatosis / Recurrent Adult Hodgkin's Lymphoma / Recurrent Adult Immunoblastic Large Cell Lymphoma / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Adult T-Cell Leukemia/Lymphoma / Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Mycosis Fungoides/Sezary Syndrome / Recurrent Small Lymphocytic Lymphoma / Refractory Multiple Myeloma / Small Intestine Lymphoma / Splenic Marginal Zone Lymphoma / Waldenström's Macroglobulinemia (WM)1
2CompletedTreatmentAllodynia / Central Neuropathic Pain / Spinal Cord Injuries (SCI)1
2CompletedTreatmentAmyotrophic Lateral Sclerosis (ALS)1
2CompletedTreatmentAutism, Early Infantile1
2CompletedTreatmentCentral Neuropathic Pain / Disseminated Sclerosis1
2CompletedTreatmentCerebrovascular Accident, Acute / Edema of the cerebrum1
2CompletedTreatmentContiguous Stage II Grade 1 Follicular Lymphoma / Contiguous Stage II Grade 2 Follicular Lymphoma / Contiguous Stage II Marginal Zone Lymphoma / Cutaneous B-Cell Non-Hodgkin Lymphoma / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Nodal marginal zone B-cell lymphomas / Noncontiguous Stage II Grade 1 Follicular Lymphoma / Noncontiguous Stage II Grade 2 Follicular Lymphoma / Noncontiguous Stage II Marginal Zone Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Marginal Zone Lymphoma / Splenic Marginal Zone Lymphoma / Stage I Grade 1 Follicular Lymphoma / Stage I Grade 2 Follicular Lymphoma / Stage I Marginal Zone Lymphoma / Stage III Grade 1 Follicular Lymphoma / Stage III Grade 2 Follicular Lymphoma / Stage III Marginal Zone Lymphoma / Stage IV Grade 1 Follicular Lymphoma / Stage IV Grade 2 Follicular Lymphoma / Stage IV Marginal Zone Lymphoma / Waldenström's Macroglobulinemia (WM)1
2CompletedTreatmentContiguous Stage II Mantle Cell Lymphoma / Noncontiguous Stage II Mantle Cell Lymphoma / Stage I Mantle Cell Lymphoma / Stage III Mantle Cell Lymphoma / Stage IV Mantle Cell Lymphoma1
2CompletedTreatmentDiabetic Neuropathies / Herpes Zoster / Neurocostal neuralgia1
2CompletedTreatmentDyskinesias / Parkinson's Disease (PD)1
2CompletedTreatmentEpisodic Migraine1
2CompletedTreatmentFacial Neuralgia / Pain / Trigeminal Neuralgia (TN)1
2CompletedTreatmentGulf War Illness1
2CompletedTreatmentHigh Blood Pressure (Hypertension)1
2CompletedTreatmentIrritable Bowel Syndrome (IBS)1
2CompletedTreatmentMajor Depressive Disorder (MDD) / Treatment Resistant1
2CompletedTreatmentMultiple Myeloma (MM)1
2CompletedTreatmentMultiple Myeloma in Relapse / Refractory Multiple Myeloma / Relapsed and Bortezomib Refractory Multiple Myeloma1
2CompletedTreatmentNeurodegenerative Disorders / Parkinson's Disease (PD)1
2CompletedTreatmentOpioid-Related Disorders / Substance-Related Disorders1
2CompletedTreatmentPain, Neuropathic1
2CompletedTreatmentPrimary Systemic Amyloidosis1
2CompletedTreatmentRett's Syndrome1
2CompletedTreatmentType 2 Diabetes Mellitus2
2Not Yet RecruitingTreatmentCancer, Breast / Estrogen Receptor Positive Tumor / Her2-Positive Breast Cancer1
2Not Yet RecruitingTreatmentCessation, Smoking / Nicotine Dependence / Smoking, Cigarette2
2Not Yet RecruitingTreatmentDiabetic Macular Edema (DME)1
2Not Yet RecruitingTreatmentDiffuse Sclerosis Systemic / Interstitial Lung Disease (ILD) / Pulmonary Hypertension (PH) / Sclerosis, Progressive Systemic1
2RecruitingOtherFibromyalgia1
2RecruitingTreatmentChemotherapy-induced Peripheral Neuropathy (CIPN)1
2RecruitingTreatmentMultiple Myeloma (MM)1
2RecruitingTreatmentPlasma Cell Myeloma / Residual Disease1
2RecruitingTreatmentSevere Aplastic Anemia (SAA)1
2TerminatedSupportive CareNausea and Vomiting / Stage III Squamous Cell Carcinoma of the Hypopharynx / Stage III Squamous Cell Carcinoma of the Larynx / Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage III Squamous Cell Carcinoma of the Nasopharynx / Stage III Squamous Cell Carcinoma of the Oropharynx / Stage IV Squamous Cell Carcinoma of the Hypopharynx / Stage IV Squamous Cell Carcinoma of the Larynx / Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage IV Squamous Cell Carcinoma of the Nasopharynx / Stage IV Squamous Cell Carcinoma of the Oropharynx1
2TerminatedTreatmentLeukemias1
2TerminatedTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL)1
2TerminatedTreatmentRecurrent Adult Acute Lymphoblastic Leukemia1
2TerminatedTreatmentRefractory Multiple Myeloma2
2TerminatedTreatmentRett's Syndrome1
2TerminatedTreatmentStage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma1
2TerminatedTreatmentTreatment Refusal1
2Unknown StatusTreatmentExtranodal NK/T-cell Lymphoma, Nasal Type1
2Unknown StatusTreatmentMalignant Lymphomas2
2Unknown StatusTreatmentRefractory Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma1
2WithdrawnTreatmentB-cell Adult Acute Lymphoblastic Leukemia / Blastic Phase Chronic Myelogenous Leukemia / Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Philadelphia Chromosome Positive Adult Precursor Acute Lymphoblastic Leukemia / Untreated Adult Acute Lymphoblastic Leukemia1
2WithdrawnTreatmentMultiple Myeloma (MM)1
2WithdrawnTreatmentRefractory Multiple Myeloma / Stage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma1
2WithdrawnTreatmentStage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma1
2, 3CompletedTreatmentSchizophrenic Disorders1
3Active Not RecruitingTreatmentB-cell Childhood Acute Lymphoblastic Leukemia / Intermediate Risk Recurrent Childhood Acute Lymphoblastic Leukemia / L1 Childhood Acute Lymphoblastic Leukemia / L2 Childhood Acute Lymphoblastic Leukemia1
3Active Not RecruitingTreatmentB-cell Childhood Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
3Active Not RecruitingTreatmentChildhood Favorable Prognosis Hodgkin Lymphoma / Childhood Lymphocyte Depletion Hodgkin Lymphoma / Childhood Mixed Cellularity Hodgkin Lymphoma / Childhood Nodular Sclerosis Hodgkin Lymphoma / Stage I Childhood Hodgkin Lymphoma / Stage II Childhood Hodgkin Lymphoma1
3CompletedDiagnosticDevelopment1
3CompletedSupportive CareChronic Myeloproliferative Disorders / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Pain / Precancerous/Nonmalignant Condition / Small Intestine Cancer / Unspecified Adult Solid Tumor, Protocol Specific1
3CompletedTreatmentAcquired Immune Deficiency Syndrome (AIDS) / Human Immunodeficiency Virus (HIV) / Human Immunodeficiency Virus (HIV) Infections1
3CompletedTreatmentBipolar Disorder (BD)1
3CompletedTreatmentChildhood Acute Erythroleukemia (M6) / Childhood Acute Megakaryocytic Leukemia (M7) / Childhood Acute Monoblastic Leukemia (M5a) / Childhood Acute Monocytic Leukemia (M5b) / Childhood Acute Myeloblastic Leukemia With Maturation (M2) / Childhood Acute Myeloblastic Leukemia Without Maturation (M1) / Childhood Acute Myelomonocytic Leukemia (M4) / Childhood Myelodysplastic Syndromes / Chronic Myelomonocytic Leukemia / De Novo Myelodysplastic Syndromes / Refractory Anemia / Refractory Anemia With Excess Blasts / Refractory Anemia With Excess Blasts in Transformation / Refractory Anemia With Ringed Sideroblasts / Secondary Myelodysplastic Syndromes / Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies1
3CompletedTreatmentChildhood Acute Lymphoblastic Leukemia in Remission / Recurrent Childhood Acute Lymphoblastic Leukemia1
3CompletedTreatmentLeukemias2
3CompletedTreatmentLight Chain Deposition Disease / Primary Systemic Amyloidosis1
3CompletedTreatmentMultiple Myeloma (MM)1
3CompletedTreatmentPseudobulbar Affect (PBA)1
3Enrolling by InvitationTreatmentBipolar Disorder II1
3Not Yet RecruitingBasic ScienceAlcoholism1
3Not Yet RecruitingTreatmentAcute Pyelonephritis / Complicated Urinary Tract Infections1
3Not Yet RecruitingTreatmentCervical Cancers1
3Not Yet RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
3RecruitingTreatmentAbortion in First Trimester1
3RecruitingTreatmentBilateral Inguinal Hernia / Neurodevelopmental Disorders1
3RecruitingTreatmentCancer of the Ovary / Fallopian Tube Cancer / Primary Peritoneal Cancer1
3RecruitingTreatmentCochlear Implants / Sensorineural Hearing Loss1
3RecruitingTreatmentMultiple Myeloma (MM)2
3RecruitingTreatmentRelapse Multiple Myeloma1
3TerminatedTreatmentMultiple Myeloma (MM)1
3TerminatedTreatmentStage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma1
3Unknown StatusTreatmentOpioid Abuse1
3Unknown StatusTreatmentProteinuria1
3Unknown StatusTreatmentRett's Syndrome1
4Active Not RecruitingSupportive CareAlzheimer's Disease (AD) / Pseudobulbar Affect (PBA)1
4CompletedBasic ScienceRejection, Transplant1
4CompletedPreventionCognition Disorders / Oxidative Stress1
4CompletedPreventionPreterm Delivery1
4CompletedSupportive CareRobotic Thyroidectomy1
4CompletedTreatmentAtherosclerosis / Inflammatory Reaction / Smoking1
4CompletedTreatmentCough Reflex Sensitivity1
4CompletedTreatmentFailed Moderate Sedation During Procedure / Minimally Conscious State1
4CompletedTreatmentHypothermia1
4CompletedTreatmentMultiple Myeloma (MM)1
4CompletedTreatmentPostoperative pain1
4Not Yet RecruitingSupportive CareColonoscopy1
4Not Yet RecruitingTreatmentPostoperative pain1
4RecruitingBasic ScienceType 2 Diabetes Mellitus1
4RecruitingOtherCYP2D6 Polymorphism1
4RecruitingTreatmentCoughing1
4RecruitingTreatmentCrohn's Disease (CD) / Ulcerative Colitis (UC)1
4RecruitingTreatmentMantle Cell Lymphoma (MCL)1
4RecruitingTreatmentNeuromuscular Block1
4RecruitingTreatmentSepsis1
4RecruitingTreatmentSpinal Cord Injuries (SCI)1
4TerminatedNot AvailablePseudobulbar Affect (Involuntary Laughing and/or Crying)1
4TerminatedTreatmentAcute Rhinitis / Upper Respiratory Tract Infections1
4Unknown StatusPreventionArrythmias / Blood Pressures / Nausea / Pain / Vomiting1
4Unknown StatusTreatmentDementias / Pseudobulbar Affect (PBA) / Strokes / Traumatic Brain Injury (TBI)1
4Unknown StatusTreatmentVitiligo1
4WithdrawnBasic ScienceSickle Cell Disorders1
Not AvailableActive Not RecruitingBasic ScienceHealthy Volunteers1
Not AvailableActive Not RecruitingOtherSleep disorders and disturbances1
Not AvailableActive Not RecruitingPreventionCoronary Artery Bypass, Off-Pump1
Not AvailableActive Not RecruitingSupportive CareAnalgesia Tolerance / Opioid Tolerance / Pain1
Not AvailableAvailableNot AvailableAttention Deficit Disorder With Hyperactivity (ADHD)1
Not AvailableCompletedNot AvailableGrowth Hormone Deficiency, Dwarfism1
Not AvailableCompletedBasic ScienceDrug-Drug Interaction (DDI) / Healthy Volunteers1
Not AvailableCompletedBasic ScienceHypovolaemia / Temperature Change, Body1
Not AvailableCompletedDiagnosticSleep Apnea Syndrome1
Not AvailableCompletedSupportive CareMale Breast Cancer / Nausea and Vomiting / Stage I Breast Carcinoma / Stage II Breast Cancer / Stage IIIA Breast Cancer1
Not AvailableCompletedSupportive CareNeoplasms, Malignant1
Not AvailableCompletedTreatmentArrythmias / Nonvalvular Atrial Fibrillation1
Not AvailableCompletedTreatmentB-cell Adult Acute Lymphoblastic Leukemia / B-cell Childhood Acute Lymphoblastic Leukemia / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia2
Not AvailableCompletedTreatmentGeneral Surgery1
Not AvailableCompletedTreatmentRett's Syndrome1
Not AvailableCompletedTreatmentRheumatoid Arthritis1
Not AvailableCompletedTreatmentT-cell Childhood Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
Not AvailableRecruitingNot AvailableCerebral Ischemia-Hypoxia1
Not AvailableRecruitingNot AvailableChildren;Infection1
Not AvailableRecruitingNot AvailableDepression1
Not AvailableRecruitingPreventionAcute Kidney Injury (AKI)1
Not AvailableRecruitingPreventionDelirium / Dexmedetomidine / Lower Extremity Problem / Propofol1
Not AvailableRecruitingTreatmentAnaesthesia therapy2
Not AvailableTerminatedNot AvailableCancer, Breast1
Not AvailableTerminatedSupportive CareTiredness / Unspecified Adult Solid Tumor, Protocol Specific / Unspecified Childhood Solid Tumor, Protocol Specific1
Not AvailableTerminatedTreatmentNeurotoxicity Syndromes1
Not AvailableUnknown StatusTreatmentRadiculopathy, Cervical1
Not AvailableWithdrawnSupportive CareIntracranial Pressure Increase1
Not AvailableWithdrawnSupportive CareNeoplasms, Malignant / Ototoxicity1

Pharmacoeconomics

Manufacturers
  • Reckitt benckiser
Packagers
  • Amend
  • BF Ascher & Co.
  • Great Southern Laboratories
  • MCR American Pharmaceuticals Inc.
  • Medisca Inc.
  • Novartis AG
  • Pharmaceutical Association
  • Prescript Pharmaceuticals
  • Procter & Gamble
  • Spectrum Pharmaceuticals
  • The F. Dohmen Co.
  • Topco
  • Wyeth Pharmaceuticals
Dosage forms
FormRouteStrength
SyrupOral20 mg
CapsuleOral15 mg/1
Tablet, effervescentOral
Granule, effervescentOral
SyrupOral3 mg
TabletOral
SyrupOral
LozengeOral30 mg
SyrupOral7.5 mg
LozengeOral7.5 mg
StripOral15 mg
Suspension / dropsOral
LiquidOral12.5 mg
LiquidTopical
LozengeOral
SuspensionOral
Solution / dropsOral
Capsule; kitOral
Kit; tabletOral
Tablet, coatedOral
Tablet, sugar coatedOral
SyrupOral20 mg/15mL
SyrupOral5 mg/5mL
Kit; powder, for solutionOral
Kit
CapsuleOral
SolutionOral15 mg/15mL
Kit97.5 mg/1
Suspension, extended releaseOral30 mg/5mL
SyrupOral30 mg/5mL
SuspensionOral30 mg
Capsule, liquid filledOral15 mg/1
Tablet, film coatedOral
ElixirOral
Tablet, chewableOral7.5 mg
SolutionOral
SyrupOral15 mg
LiquidOral7.5 mg/5mL
TabletOral15 mg
CapsuleOral30 mg
SolutionOral7.5 mg
SyrupOral30 mg
Tablet, orally disintegratingOral30 mg/1
KitOral
LiquidOral20 mg/5mL
GranuleOral
Kit; powderOral
Powder, for solutionOral
Solution / dropsNasal
LiquidOral30 mg/10mL
PowderOral
StripOral7.5 mg
Tablet, chewableOral
SyrupOral5 mg
Tablet, orally disintegratingOral
SuspensionOral30 mg/5mL
Tablet, extended releaseOral
Capsule, liquid filledOral
StripOral
Capsule, gelatin coatedOral
Capsule, coatedOral
Capsule, gelatin coatedOral15 mg/1
LiquidOral15 mg
LiquidOral7.5 mg
PatchTopical
Granule, for solutionOral
LiquidOral
CapsuleOral15 mg
SyrupOral10 mg
LiquidOral15 mg/5mL
LiquidOral30 mg/3mL
LiquidOral10 mg/5mL
LiquidOral30 mg/5mL
LozengeOral10 mg/1
LozengeOral15 mg
LozengeOral5 mg
LozengeOral10 mg
LiquidOral15 mg/15mL
SyrupOral7.5 mg/5mL
TabletOral7.5 mg
SolutionOral30 mg/10mL
SuspensionOral1000 mg/1
Capsule, liquid filledOral12.5 mg/5mL
SolutionOral12.5 mg/1
LiquidOral30 mg/15mL
LiquidOral30 mg
LiquidOral30 mg/30mL
SprayOral6 mg/0.25mL
Prices
Unit descriptionCostUnit
Modicon (28) 28 0.5-35 mg-mcg tablet Disp Pack59.99USD disp
Dextromethorphan powder14.93USD g
Dextromethorphan hbr powder4.74USD g
Dextromethorphan hbr cryst2.06USD g
Triaminic allergy thin strip0.35USD strip
Triaminic cold-stuff nose strip0.35USD strip
Triaminic cgh-runny nose strip0.3USD each
Triaminic cough strips0.3USD strip
Triaminic cough-cold chew0.27USD each
Triaminic softchew tablet0.27USD tablet
Robitussin coughgels0.25USD each
Triaminic softchews tablet0.25USD tablet
Childrens triaminic decon spray0.24USD ml
Hold 4 hour lozenge regular0.24USD lozenge
Hca severe cough stopper cplet0.23USD each
Triaminicin tablet0.23USD tablet
Delsym 30 mg/5 ml suspension0.11USD ml
Robitussin dm to go liquid0.09USD ml
Apap allergy sinus caplet0.05USD caplet
Adlt robitussin cough-cold-flu0.04USD ml
Adt robitussin cough-cold d lq0.04USD ml
Adult robitussin cough syrup0.04USD ml
Robitussin chest congest syrup0.04USD ml
Robitussin cough & cold liquid0.04USD ml
Robitussin cough-cold liquid0.04USD ml
Robitussin cough-cong syrup0.04USD ml
Robitussin dm max liquid0.04USD ml
Robitussin long-acting liq0.04USD ml
Robitussin pe head & chest liq0.04USD ml
Robitussin-cough-chest-cong lq0.04USD ml
Robitussin-dm cough syrup0.04USD ml
Triaminic chest-nasal cong liq0.04USD ml
Triaminic cold & cough liquid0.04USD ml
Triaminic cold-allergy pe liq0.04USD ml
Triaminic cough-nasal cong liq0.04USD ml
Triaminic cough-sore throat lq0.04USD ml
Triaminic flu cough-fever susp0.04USD ml
Triaminic flu-cough-fever liq0.04USD ml
Triaminic-d syrup0.04USD ml
Vicks 44 cough liquid0.03USD ml
Vicks 44 custom care liquid0.03USD ml
Guaifenesin dm syrup0.02USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5980882No1997-04-162017-04-16Us
US6372252No2000-04-282020-04-28Us
US6955821No2000-04-282020-04-28Us
US7838032No2000-04-282020-04-28Us
US7659282No2006-08-132026-08-13Us
US8227484No2003-07-172023-07-17Us
USRE38115No1996-01-262016-01-26Us

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)122-124Schnider, O. and Grussner, A,; US. Patent 2,676,177; April 20, 1954; assigned to Hoffrnann-La Roche Inc.
water solubility74.7 mg/LNot Available
logP3.6Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00851 mg/mLALOGPS
logP3.75ALOGPS
logP3.49ChemAxon
logS-4.5ALOGPS
pKa (Strongest Basic)9.85ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area12.47 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity82.56 m3·mol-1ChemAxon
Polarizability31.86 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9959
Blood Brain Barrier+0.9989
Caco-2 permeable+0.8867
P-glycoprotein substrateSubstrate0.8288
P-glycoprotein inhibitor IInhibitor0.654
P-glycoprotein inhibitor IINon-inhibitor0.8383
Renal organic cation transporterInhibitor0.7893
CYP450 2C9 substrateNon-substrate0.8187
CYP450 2D6 substrateSubstrate0.8919
CYP450 3A4 substrateSubstrate0.7783
CYP450 1A2 substrateNon-inhibitor0.9046
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorInhibitor0.8932
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.8308
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8673
Ames testNon AMES toxic0.5664
CarcinogenicityNon-carcinogens0.9616
BiodegradationNot ready biodegradable0.9763
Rat acute toxicity3.3377 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.7107
hERG inhibition (predictor II)Inhibitor0.6723
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Mass Spectrum (Electron Ionization)MSsplash10-00di-5890000000-3009baa7e8a19f9be270
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-014i-0190000000-df99af2429c385c2ac44
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-00di-0090000000-1a3ed289b3e93cd6fde4
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-00di-0090000000-ebc22884ca50d755e2e4
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-00di-0090000000-63612671cfd5e7808f7e
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-02mi-0490000000-10cc5d461942becb6194
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-022a-0930000000-943342d8d5a3ae45227f
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-00di-0900000000-eb4c5442e33e6921c728
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-00di-0090000000-a39a4c295bd6e3b25181
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-00di-0090000000-5191ea197708a687222f
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-00di-0090000000-3d90a3bd5c1b6788ed43
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-02mi-0490000000-ddc598f28e1a4f9008d1
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-022a-0940000000-cbb4007ab43d33441b69
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-00dj-0900000000-457827e6b58fa1a77623
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-014i-0190000000-23c81d81c3ea162f7ab7

Taxonomy

Description
This compound belongs to the class of organic compounds known as morphinans. These are polycyclic compounds with a four-ring skeleton with three condensed six-member rings forming a partially hydrogenated phenanthrene moiety, one of which is aromatic while the two others are alicyclic.
Kingdom
Organic compounds
Super Class
Alkaloids and derivatives
Class
Morphinans
Sub Class
Not Available
Direct Parent
Morphinans
Alternative Parents
Phenanthrenes and derivatives / Benzazocines / Tetralins / Anisoles / Aralkylamines / Alkyl aryl ethers / Piperidines / Trialkylamines / Azacyclic compounds / Organopnictogen compounds
show 1 more
Substituents
Morphinan / Phenanthrene / Benzazocine / Tetralin / Anisole / Alkyl aryl ether / Aralkylamine / Piperidine / Benzenoid / Tertiary aliphatic amine
show 12 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Agonist
General Function
Opioid receptor activity
Specific Function
Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma m...
Gene Name
SIGMAR1
Uniprot ID
Q99720
Uniprot Name
Sigma non-opioid intracellular receptor 1
Molecular Weight
25127.52 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Shin EJ, Nah SY, Chae JS, Bing G, Shin SW, Yen TP, Baek IH, Kim WK, Maurice T, Nabeshima T, Kim HC: Dextromethorphan attenuates trimethyltin-induced neurotoxicity via sigma1 receptor activation in rats. Neurochem Int. 2007 May;50(6):791-9. Epub 2007 Feb 4. [PubMed:17386960]
  4. Shin EJ, Nah SY, Kim WK, Ko KH, Jhoo WK, Lim YK, Cha JY, Chen CF, Kim HC: The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via sigma1 receptor activation: comparison with the effects of dextromethorphan. Br J Pharmacol. 2005 Apr;144(7):908-18. [PubMed:15723099]
  5. Church AJ, Andrew RD: Spreading depression expands traumatic injury in neocortical brain slices. J Neurotrauma. 2005 Feb;22(2):277-90. [PubMed:15716633]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Agonist
General Function
Not Available
Specific Function
Not Available
Gene Name
SIGMAR1
Uniprot ID
Q5T1J1
Uniprot Name
HCG20471, isoform CRA_c
Molecular Weight
14852.655 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Chou YC, Liao JF, Chang WY, Lin MF, Chen CF: Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan. Brain Res. 1999 Mar 13;821(2):516-9. [PubMed:10064839]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Antagonist
General Function
Protein phosphatase 2a binding
Specific Function
NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May ...
Gene Name
GRIN3A
Uniprot ID
Q8TCU5
Uniprot Name
Glutamate receptor ionotropic, NMDA 3A
Molecular Weight
125464.07 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Chou YC, Liao JF, Chang WY, Lin MF, Chen CF: Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan. Brain Res. 1999 Mar 13;821(2):516-9. [PubMed:10064839]
  4. Wong BY, Coulter DA, Choi DW, Prince DA: Dextrorphan and dextromethorphan, common antitussives, are antiepileptic and antagonize N-methyl-D-aspartate in brain slices. Neurosci Lett. 1988 Feb 29;85(2):261-6. [PubMed:2897648]
  5. Kamel IR, Wendling WW, Chen D, Wendling KS, Harakal C, Carlsson C: N-methyl-D-aspartate (NMDA) antagonists--S(+)-ketamine, dextrorphan, and dextromethorphan--act as calcium antagonists on bovine cerebral arteries. J Neurosurg Anesthesiol. 2008 Oct;20(4):241-8. doi: 10.1097/ANA.0b013e31817f523f. [PubMed:18812887]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Antagonist
General Function
Drug binding
Specific Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Gene Name
CHRNA2
Uniprot ID
Q15822
Uniprot Name
Neuronal acetylcholine receptor subunit alpha-2
Molecular Weight
59764.82 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Damaj MI, Flood P, Ho KK, May EL, Martin BR: Effect of dextrometorphan and dextrorphan on nicotine and neuronal nicotinic receptors: in vitro and in vivo selectivity. J Pharmacol Exp Ther. 2005 Feb;312(2):780-5. Epub 2004 Sep 8. [PubMed:15356218]
  4. Lee JH, Shin EJ, Jeong SM, Kim JH, Lee BH, Yoon IS, Lee JH, Choi SH, Lee SM, Lee PH, Kim HC, Nah SY: Effects of dextrorotatory morphinans on alpha3beta4 nicotinic acetylcholine receptors expressed in Xenopus oocytes. Eur J Pharmacol. 2006 Apr 24;536(1-2):85-92. Epub 2006 Mar 2. [PubMed:16563374]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Serotonin:sodium symporter activity
Specific Function
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into t...
Gene Name
SLC6A4
Uniprot ID
P31645
Uniprot Name
Sodium-dependent serotonin transporter
Molecular Weight
70324.165 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Codd EE, Shank RP, Schupsky JJ, Raffa RB: Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception. J Pharmacol Exp Ther. 1995 Sep;274(3):1263-70. [PubMed:7562497]
  4. Henderson MG, Fuller RW: Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats. Brain Res. 1992 Oct 30;594(2):323-6. [PubMed:1280529]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Binder
General Function
Steroid binding
Specific Function
Receptor for progesterone.
Gene Name
PGRMC1
Uniprot ID
O00264
Uniprot Name
Membrane-associated progesterone receptor component 1
Molecular Weight
21670.9 Da
References
  1. Chou YC, Liao JF, Chang WY, Lin MF, Chen CF: Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan. Brain Res. 1999 Mar 13;821(2):516-9. [PubMed:10064839]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Antagonist
General Function
Ligand-gated ion channel activity
Specific Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Gene Name
CHRNA3
Uniprot ID
P32297
Uniprot Name
Neuronal acetylcholine receptor subunit alpha-3
Molecular Weight
57479.54 Da
References
  1. Damaj MI, Flood P, Ho KK, May EL, Martin BR: Effect of dextrometorphan and dextrorphan on nicotine and neuronal nicotinic receptors: in vitro and in vivo selectivity. J Pharmacol Exp Ther. 2005 Feb;312(2):780-5. Epub 2004 Sep 8. [PubMed:15356218]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Antagonist
General Function
Ligand-gated ion channel activity
Specific Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeabl...
Gene Name
CHRNA4
Uniprot ID
P43681
Uniprot Name
Neuronal acetylcholine receptor subunit alpha-4
Molecular Weight
69956.47 Da
References
  1. Damaj MI, Flood P, Ho KK, May EL, Martin BR: Effect of dextrometorphan and dextrorphan on nicotine and neuronal nicotinic receptors: in vitro and in vivo selectivity. J Pharmacol Exp Ther. 2005 Feb;312(2):780-5. Epub 2004 Sep 8. [PubMed:15356218]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Antagonist
General Function
Ligand-gated ion channel activity
Specific Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Gene Name
CHRNB4
Uniprot ID
P30926
Uniprot Name
Neuronal acetylcholine receptor subunit beta-4
Molecular Weight
56378.985 Da
References
  1. Damaj MI, Flood P, Ho KK, May EL, Martin BR: Effect of dextrometorphan and dextrorphan on nicotine and neuronal nicotinic receptors: in vitro and in vivo selectivity. J Pharmacol Exp Ther. 2005 Feb;312(2):780-5. Epub 2004 Sep 8. [PubMed:15356218]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Antagonist
General Function
Ligand-gated ion channel activity
Specific Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeabl...
Gene Name
CHRNB2
Uniprot ID
P17787
Uniprot Name
Neuronal acetylcholine receptor subunit beta-2
Molecular Weight
57018.575 Da
References
  1. Damaj MI, Flood P, Ho KK, May EL, Martin BR: Effect of dextrometorphan and dextrorphan on nicotine and neuronal nicotinic receptors: in vitro and in vivo selectivity. J Pharmacol Exp Ther. 2005 Feb;312(2):780-5. Epub 2004 Sep 8. [PubMed:15356218]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Antagonist
General Function
Toxic substance binding
Specific Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The cha...
Gene Name
CHRNA7
Uniprot ID
P36544
Uniprot Name
Neuronal acetylcholine receptor subunit alpha-7
Molecular Weight
56448.925 Da
References
  1. Damaj MI, Flood P, Ho KK, May EL, Martin BR: Effect of dextrometorphan and dextrorphan on nicotine and neuronal nicotinic receptors: in vitro and in vivo selectivity. J Pharmacol Exp Ther. 2005 Feb;312(2):780-5. Epub 2004 Sep 8. [PubMed:15356218]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Agonist
General Function
Voltage-gated calcium channel activity
Specific Function
Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone...
Gene Name
OPRM1
Uniprot ID
P35372
Uniprot Name
Mu-type opioid receptor
Molecular Weight
44778.855 Da
References
  1. Codd EE, Shank RP, Schupsky JJ, Raffa RB: Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception. J Pharmacol Exp Ther. 1995 Sep;274(3):1263-70. [PubMed:7562497]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Agonist
General Function
Opioid receptor activity
Specific Function
G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine n...
Gene Name
OPRD1
Uniprot ID
P41143
Uniprot Name
Delta-type opioid receptor
Molecular Weight
40368.235 Da
References
  1. Codd EE, Shank RP, Schupsky JJ, Raffa RB: Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception. J Pharmacol Exp Ther. 1995 Sep;274(3):1263-70. [PubMed:7562497]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Agonist
General Function
Opioid receptor activity
Specific Function
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synt...
Gene Name
OPRK1
Uniprot ID
P41145
Uniprot Name
Kappa-type opioid receptor
Molecular Weight
42644.665 Da
References
  1. Codd EE, Shank RP, Schupsky JJ, Raffa RB: Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception. J Pharmacol Exp Ther. 1995 Sep;274(3):1263-70. [PubMed:7562497]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Voltage-gated ion channel activity
Specific Function
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH ...
Gene Name
CYBB
Uniprot ID
P04839
Uniprot Name
Cytochrome b-245 heavy chain
Molecular Weight
65335.415 Da
References
  1. Zhang W, Wang T, Qin L, Gao HM, Wilson B, Ali SF, Zhang W, Hong JS, Liu B: Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase. FASEB J. 2004 Mar;18(3):589-91. Epub 2004 Jan 20. [PubMed:14734632]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Norepinephrine:sodium symporter activity
Specific Function
Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name
SLC6A2
Uniprot ID
P23975
Uniprot Name
Sodium-dependent noradrenaline transporter
Molecular Weight
69331.42 Da
References
  1. Codd EE, Shank RP, Schupsky JJ, Raffa RB: Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception. J Pharmacol Exp Ther. 1995 Sep;274(3):1263-70. [PubMed:7562497]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...
Gene Name
CYP2D6
Uniprot ID
P10635
Uniprot Name
Cytochrome P450 2D6
Molecular Weight
55768.94 Da
References
  1. Zhou SF: Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I. Clin Pharmacokinet. 2009;48(11):689-723. doi: 10.2165/11318030-000000000-00000. [PubMed:19817501]
  2. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014]
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  4. Zhang T, Zhu Y, Gunaratna C: Rapid and quantitative determination of metabolites from multiple cytochrome P450 probe substrates by gradient liquid chromatography-electrospray ionization-ion trap mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Nov 25;780(2):371-9. [PubMed:12401364]
  5. Yu A, Haining RL: Comparative contribution to dextromethorphan metabolism by cytochrome P450 isoforms in vitro: can dextromethorphan be used as a dual probe for both CTP2D6 and CYP3A activities? Drug Metab Dispos. 2001 Nov;29(11):1514-20. [PubMed:11602530]
  6. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
  7. Source [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  3. Yu A, Haining RL: Comparative contribution to dextromethorphan metabolism by cytochrome P450 isoforms in vitro: can dextromethorphan be used as a dual probe for both CTP2D6 and CYP3A activities? Drug Metab Dispos. 2001 Nov;29(11):1514-20. [PubMed:11602530]
  4. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A5
Uniprot ID
P20815
Uniprot Name
Cytochrome P450 3A5
Molecular Weight
57108.065 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A7
Uniprot ID
P24462
Uniprot Name
Cytochrome P450 3A7
Molecular Weight
57525.03 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2B6
Uniprot ID
P20813
Uniprot Name
Cytochrome P450 2B6
Molecular Weight
56277.81 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  2. Yu A, Haining RL: Comparative contribution to dextromethorphan metabolism by cytochrome P450 isoforms in vitro: can dextromethorphan be used as a dual probe for both CTP2D6 and CYP3A activities? Drug Metab Dispos. 2001 Nov;29(11):1514-20. [PubMed:11602530]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and im...
Gene Name
CYP2C19
Uniprot ID
P33261
Uniprot Name
Cytochrome P450 2C19
Molecular Weight
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C9
Uniprot ID
P11712
Uniprot Name
Cytochrome P450 2C9
Molecular Weight
55627.365 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C8
Uniprot ID
P10632
Uniprot Name
Cytochrome P450 2C8
Molecular Weight
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic ...
Gene Name
CYP2E1
Uniprot ID
P05181
Uniprot Name
Cytochrome P450 2E1
Molecular Weight
56848.42 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]

Drug created on June 13, 2005 07:24 / Updated on September 17, 2018 21:09