Insecticides

Name
Insecticides
Accession Number
DBCAT000857
Description

Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics.

Drugs
DrugDrug Description
LindaneAn ectoparasiticide and ovicide used in the treatment of Pediculosis humanis capitis (head lice) and Phthirus pubis (crab lice).
IvermectinAn anti parasite medication used to treat head lice, onchocerciasis, strongyloidiasis, ascariasis, trichuriasis, and enterobiasis.
Benzyl benzoateUsed to kill lice and the mites responsible for the skin condition scabies.
MalathionA parasympathomimetic organophosphate used to treat head lice.
AllosamidinAllosamidin exhibits extremely potent inhibitory activity against chitinases from a number of sources, particularly from Candida albicans, and can be utilized as potent antifungal agent.
PermethrinAn insecticide used to prevent infestation with Sarcoptes scabiei (scabies).
SpinosadA pediculicide used topically to treat head lice.
Pyrethrum extractA chrysanthemum flower extract used to treat head, pubic, and body lice.
Boric acidNo FDA- or EMA-approved therapeutic indications on its own.
AmitrazAmitraz is a non-systemic acaricide and insecticide. It was generated in 1969 by the Boots Co. in England. Amitraz presents insect repellent effects and hence, it can be used as...
CoumaphosThis drug is a fat-soluble phosphorothioate agent that kills both insects and mites. It is non-volatile in nature and is well known by a variety of names as such a...
CythioateCythioate is a member of the organothiophosphate compounds that is used as an insecticide and anthelmintic. It is mainly used in veterinary as a treatment for fleas.
DichlorvosDichlorvos or 2,2-dichlorovinyl dimethyl phosphate is a drug of the organophosphate class, frequently used as an insecticide for the control of indoor pests and for the protection of stored products...
DoramectinDoramectin is a veterinary drug approved by the Food and Drug Administration for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in...
EprinomectinNot Annotated
FamphurNot Annotated
FenthionFenthion is an organothiophosphate drug used as an insecticide, avicide, and acaricide. Its mode of action is explained by cholinesterase enzyme inhibition, which is similar to other organophosphates. Fenthion is...
ImidaclopridImidacloprid is a neonicotinoid, which is a class of neuro-active insecticides modeled after nicotine. Imidacloprid is a patented chemical, Imidacloprid is manufactured by Bayer Cropscience (part of Bayer AG) and...
LufenuronLufenuron is used in veterinary for the control of flea.
MoxidectinMoxidectin is indicated for the treatment of river blindness, also called onchocerciasis, in patients aged 12 years and older. River blindness is caused by a parasitic worm Onchocerca volvulus and...
PhosmetPhosmet is a phthalimide-derived organophosphate. It is a non-specific insecticide. It is mainly used on apple trees to control codling moths. It is also used on other fruit crops, ornamentals,...
RotenoneRotenone is an isoflavone compound that naturally occurs in the jicama vine plant as well as many Fabaceae plants. It has broad spectrum insecticide and pesticide activity and is also...
MetrifonateMetrifonate or trichlorfon is an irreversible organophosphate acetylcholinesterase inhibitor. It is a prodrug which is activated non-enzymatically into 2,2-dichlorovinyl dimethyl phosphate.
TemefosDiphos has been used in trials studying the treatment of Plasmodium Falciparum Malaria.
NeosaxitoxinNeosaxitoxin is under investigation in clinical trial NCT01786655 (Safety Study of Long-Acting Local Anesthetic).
ParaoxonNot Annotated
DeltamethrinNot Annotated
PhenothrinNot Annotated
CypermethrinNot Annotated
BioallethrinBioallethrin was used for lice and scabies infestation. Other pyrethroids are now used in place of bioallethrin.
TetramethrinNot Annotated
CyfluthrinNot Annotated
1,2-dichlorobenzene1,2-Dichlorobenzene, also named ortho-dichlorobenzene, is an organic compound. It is a non-polar colorless liquid that is miscible in most organic solvents. This derivative of benzene differs from the parent compound...
MethamidophosMethamidophos is under investigation in clinical trial NCT03223753 (Web-Based Physical Activity Intervention in Improving Long Term Health in Children and Adolescents With Newly Diagnosed Acute Lymphoblastic Leukemia in First Remission).
NitenpyramNitenpyram is an insecticide used in agriculture and veterinary medicine to kill external parasites of pets. It is a neonicotinoid, a neurotoxin that blocks neural messages and binds particularly tightly...
TransfluthrinTransfluthrin is under investigation in clinical trial NCT02394522 (Spatial Repellent Products for Control of Vector Borne Diseases - Malaria - Zambia (SR-M-ZM)).
ThiaclopridNot Available
Drugs & Drug Targets
DrugTargetType
LindaneGamma-aminobutyric acid receptor subunit beta-1target
LindaneGlycine receptor subunit alpha-1target
LindaneGlycine receptor subunit alpha-2target
LindaneGlycine receptor subunit alpha-3target
LindaneGlycine receptor subunit betatarget
LindaneGamma-aminobutyric acid receptor subunit beta-3target
LindaneGamma-aminobutyric acid receptor subunit rho-1target
LindaneProgesterone receptortarget
LindaneEstrogen receptor alphatarget
LindaneNuclear receptor subfamily 1 group I member 2target
IvermectinGamma-aminobutyric acid receptor subunit beta-3target
IvermectinGlycine receptor subunit alpha-3target
IvermectinP-glycoprotein 1transporter
IvermectinMultidrug resistance-associated protein 1transporter
IvermectinCanalicular multispecific organic anion transporter 1transporter
IvermectinATP-binding cassette sub-family G member 2transporter
IvermectinCytochrome P450 3A4enzyme
IvermectinSolute carrier organic anion transporter family member 1B1transporter
IvermectinSolute carrier organic anion transporter family member 1B3transporter
MalathionCholinesterasetarget
MalathionCytochrome P450 1A2enzyme
MalathionCytochrome P450 2B6enzyme
AllosamidinChitinase Btarget
AllosamidinChitinase Atarget
PermethrinCytochrome P450 2B6enzyme
PermethrinSodium channel protein type 1 subunit alphatarget
PermethrinEstrogen receptor alphatarget
PermethrinNuclear receptor subfamily 1 group I member 2target
Pyrethrum extractNuclear receptor subfamily 1 group I member 2target
DichlorvosSerum albumincarrier
DichlorvosSerotransferrintarget
DichlorvosCholinesterasetarget
DoramectinCytochrome P450 3A4enzyme
EprinomectinCytochrome P450 3A4enzyme
ImidaclopridCHRNA7-FAM7A fusion proteintarget
MoxidectinCYP2B proteinenzyme
MoxidectinGlutamate-gated chloride channeltarget
MoxidectinGABA-A gated chloride channeltarget
MoxidectinABC transporterstarget
BioallethrinVoltage-gated sodium channel alpha subunittarget
BioallethrinSodium channel proteintarget
BioallethrinVoltage-dependent calcium channeltarget
BioallethrinVoltage-dependent T-type calcium channeltarget
BioallethrinVoltage-dependent P/Q-type calcium channeltarget
BioallethrinVoltage-dependent L-type calcium channeltarget
BioallethrinCytochrome P450 2C8enzyme
BioallethrinCytochrome P450 2C9enzyme
BioallethrinCytochrome P450 2C19enzyme
BioallethrinCytochrome P450 3A4enzyme
BioallethrinCytochrome P450 2A1enzyme
BioallethrinCytochrome P450 1A1enzyme
BioallethrinCytochrome P450 2C6enzyme
BioallethrinCytochrome P450 2C11enzyme
BioallethrinCytochrome P450 3A1enzyme
BioallethrinCytochrome P450 3A2enzyme
1,2-dichlorobenzeneCytochrome P450 2E1enzyme
ThiaclopridCHRNA7-FAM7A fusion proteintarget