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Identification
NameIvermectin
Accession NumberDB00602  (APRD01058)
TypeSmall Molecule
GroupsApproved, Vet Approved
DescriptionIvermectin is a broad-spectrum anti-parasite medication. It was first marketed under the name Stromectol® and used against worms (except tapeworms), but, in 2012, it was approved for the topical treatment of head lice infestations in patients 6 months of age and older, and marketed under the name Sklice™ as well. Ivermectin is mainly used in humans in the treatment of onchocerciasis, but is also effective against other worm infestations (such as strongyloidiasis, ascariasis, trichuriasis and enterobiasis).
Structure
Thumb
Synonyms
Ivermectin
Ivermectina
Ivermectine
Ivermectinum
External Identifiers
  • MK 933
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
RosiverCream1 %TopicalGalderma Canada Inc2015-05-25Not applicableCanada
SkliceLotion5 mg/gTopicalArbor Pharmaceuticals2016-06-30Not applicableUs
SkliceLotion.585 g/117gTopicalSanofi Pasteur, Inc2012-07-09Not applicableUs
SoolantraCream10 mg/gTopicalGalderma Laboratories, L.P.2015-01-01Not applicableUs
StromectolTablet3 mg/1OralMerck Sharp & Dohme Corp.1996-11-22Not applicableUs
StromectolTablet3 mg/1OralDepartment Of State Health Services, Pharmacy Branch1996-11-22Not applicableUs
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
IvermectinTablet3 mg/1OralEdenbridge Pharmaceuticals, LLC2014-11-15Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AscapilAbbott
DetebencilRoux-Ocefa
ErmetinUnipharm
GotaxMetlen
ImectinPulse
IvectinAristopharma
IveraBeximco
IvergotLicol
IvermecUCI
IvextermValeant
IvoriInvision
KaonolMediderm
KiloxBussié
MaikedingHisun
QuanoxDermacare
RevectinaSolvay
ScaboDelta
ScavistaZuventus
SecuroValeant
VermectinAtlantic Lab
Brand mixturesNot Available
SaltsNot Available
Categories
UNII8883YP2R6D
CAS number70288-86-7
WeightAverage: 1736.1589
Monoisotopic: 1735.000064088
Chemical FormulaC95H146O28
InChI KeySPBDXSGPUHCETR-CVSKBELMSA-N
InChI
InChI=1S/C48H74O14.C47H72O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38;1-24(2)41-27(5)16-17-46(61-41)22-33-19-32(60-46)15-14-26(4)42(25(3)12-11-13-31-23-54-44-39(48)28(6)18-34(45(50)57-33)47(31,44)51)58-38-21-36(53-10)43(30(8)56-38)59-37-20-35(52-9)40(49)29(7)55-37/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3;11-14,18,24-25,27,29-30,32-44,48-49,51H,15-17,19-23H2,1-10H3/b13-12+,27-15+,32-14+;12-11+,26-14+,31-13+/t25-,26+,28+,30+,31+,33-,34+,35+,36+,37+,38+,39+,40-,41+,42+,43-,44+,45-,47-,48-;25-,27-,29-,30-,32+,33-,34-,35-,36-,37-,38-,39+,40-,41+,42-,43-,44+,46+,47+/m10/s1
IUPAC Name
(1'R,2R,4'S,5S,6R,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-21',24'-dihydroxy-12'-{[(2R,4S,5S,6S)-5-{[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-4-methoxy-6-methyloxan-2-yl]oxy}-5,11',13',22'-tetramethyl-6-(propan-2-yl)-3',7',19'-trioxaspiro[oxane-2,6'-tetracyclo[15.6.1.1⁴,⁸.0²⁰,²⁴]pentacosane]-10',14',16',22'-tetraen-2'-one; (1'R,2R,4'S,5S,6R,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-6-[(2R)-butan-2-yl]-21',24'-dihydroxy-12'-{[(2R,4S,5S,6S)-5-{[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-4-methoxy-6-methyloxan-2-yl]oxy}-5,11',13',22'-tetramethyl-3',7',19'-trioxaspiro[oxane-2,6'-tetracyclo[15.6.1.1⁴,⁸.0²⁰,²⁴]pentacosane]-10',14',16',22'-tetraen-2'-one
SMILES
CO[[email protected]]1C[C@@H](O[C@@H](C)[C@@H]1O)O[[email protected]]1[[email protected]](C)O[[email protected]](C[C@@H]1OC)O[[email protected]]1[C@@H](C)\C=C\C=C2/CO[C@@H]3[[email protected]](O)C(C)=C[C@@H](C(=O)O[[email protected]]4C[C@@H](C\C=C1/C)O[C@@]1(CC[[email protected]](C)[C@@H](C(C)C)O1)C4)[C@]23O.CC[C@@H](C)[[email protected]]1O[C@@]2(CC[C@@H]1C)O[C@@H]1C\C=C(C)\[C@@H](O[C@@H]3O[C@@H](C)[[email protected]](O[C@@H]4O[C@@H](C)[[email protected]](O)[C@@H](OC)C4)[C@@H](OC)C3)[C@@H](C)\C=C\C=C3/CO[C@@H]4[[email protected]](O)C(C)=C[C@@H](C(=O)O[C@@H](C1)C2)[C@]34O
Pharmacology
IndicationFor the treatment of intestinal (i.e., nondisseminated) strongyloidiasis due to the nematode parasite Strongyloides stercoralis. Also for the treatment of onchocerciasis (river blindness) due to the nematode parasite Onchocerca volvulus. Can be used to treat scabies caused by Sarcoptes scabiei.
Structured Indications
PharmacodynamicsIvermectin is a semisynthetic, anthelminitic agent. It is an avermectin which a group of pentacyclic sixteen-membered lactone (i.e. a macrocyclic lactone disaccharide) derived from the soil bacterium Streptomyces avermitilis. Avermectins are potent anti-parasitic agents. Ivermectin is the most common avermectin. It is a broad spectrum antiparasitic drug for oral administration. It is sometimes used to treat human onchocerciasis (river blindness). It is the mixture of 22,23-dihydro-avermectin B1a (at least 90%) and 22,23-dihydro-avermectin B1b (less than 10%).
Mechanism of actionIvermectin binds selectively and with high affinity to glutamate-gated chloride ion channels in invertebrate muscle and nerve cells of the microfilaria. This binding causes an increase in the permeability of the cell membrane to chloride ions and results in hyperpolarization of the cell, leading to paralysis and death of the parasite. Ivermectin also is believed to act as an agonist of the neurotransmitter gamma-aminobutyric acid (GABA), thereby disrupting GABA-mediated central nervous system (CNS) neurosynaptic transmission. Ivermectin may also impair normal intrauterine development of O. volvulus microfilariae and may inhibit their release from the uteri of gravid female worms.
TargetKindPharmacological actionActionsOrganismUniProt ID
Gamma-aminobutyric acid receptor subunit beta-3Proteinunknown
agonist
HumanP28472 details
Glycine receptor subunit alpha-3Proteinyes
agonist
HumanO75311 details
Related Articles
AbsorptionModerately well absorbed. Improved absorption with high fat meal.
Volume of distribution

The volume of distribution is 3 to 3.5 L/kg and it does not cross the blood-brain barrier.

Protein binding93%
Metabolism

Primarily hepatic. Ivermectin and/or its metabolites are excreted almost exclusively in the feces over an estimated 12 days, with less than 1 % of the administered dose excreted in the urine.

Route of eliminationIvermectin is metabolized in the liver, and ivermectin and/or its metabolites are excreted almost exclusively in the feces over an estimated 12 days, with less than 1% of the administered dose excreted in the urine.
Half life16 hours (also reported at 22-28 hours)
ClearanceNot Available
ToxicityLD50 = 29.5 mg/kg (Mouse, oral). LD50 = 10 mg/kg (Rat, oral). Adverse effects include muscle or joint pain, dizziness, fever, headache, skin rash, fast heartbeat.
Affected organisms
  • Parasitic nematodes and other roundworms
  • Head lice
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Ivermectin.Approved
AcenocoumarolIvermectin may increase the anticoagulant activities of Acenocoumarol.Approved
AcetaminophenThe serum concentration of Ivermectin can be increased when it is combined with Acetaminophen.Approved
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Ivermectin.Approved, Vet Approved
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Ivermectin.Approved
AlbendazoleThe serum concentration of Ivermectin can be increased when it is combined with Albendazole.Approved, Vet Approved
AldosteroneThe serum concentration of Ivermectin can be decreased when it is combined with Aldosterone.Experimental
AlectinibThe serum concentration of Ivermectin can be increased when it is combined with Alectinib.Approved
AlfentanilThe serum concentration of Ivermectin can be increased when it is combined with Alfentanil.Approved, Illicit
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Ivermectin.Approved, Investigational
AmantadineThe serum concentration of Ivermectin can be increased when it is combined with Amantadine.Approved
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Ivermectin.Approved, Investigational
Aminohippuric acidThe serum concentration of Ivermectin can be increased when it is combined with Aminohippuric acid.Approved
AmiodaroneThe metabolism of Ivermectin can be decreased when combined with Amiodarone.Approved, Investigational
AmitriptylineThe serum concentration of Ivermectin can be increased when it is combined with Amitriptyline.Approved
AmlodipineThe serum concentration of Ivermectin can be increased when it is combined with Amlodipine.Approved
AmodiaquineThe serum concentration of Ivermectin can be decreased when it is combined with Amodiaquine.Approved
AmprenavirThe serum concentration of Ivermectin can be decreased when it is combined with Amprenavir.Approved
AmsacrineThe serum concentration of Ivermectin can be increased when it is combined with Amsacrine.Approved
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Ivermectin.Approved
AprepitantThe serum concentration of Ivermectin can be increased when it is combined with Aprepitant.Approved, Investigational
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Ivermectin.Approved, Investigational
AstemizoleThe serum concentration of Ivermectin can be increased when it is combined with Astemizole.Approved, Withdrawn
AtazanavirThe metabolism of Ivermectin can be decreased when combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Ivermectin can be increased when it is combined with Atenolol.Approved
AtomoxetineThe metabolism of Ivermectin can be decreased when combined with Atomoxetine.Approved
AtorvastatinThe serum concentration of Ivermectin can be increased when it is combined with Atorvastatin.Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Ivermectin.Approved, Investigational
AzelastineThe serum concentration of Ivermectin can be increased when it is combined with Azelastine.Approved
AzithromycinThe serum concentration of Ivermectin can be increased when it is combined with Azithromycin.Approved
BenzocaineThe serum concentration of Ivermectin can be increased when it is combined with Benzocaine.Approved
BepridilThe serum concentration of Ivermectin can be increased when it is combined with Bepridil.Approved, Withdrawn
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Ivermectin.Approved, Vet Approved
BexaroteneThe serum concentration of Ivermectin can be decreased when it is combined with Bexarotene.Approved, Investigational
BiperidenThe serum concentration of Ivermectin can be increased when it is combined with Biperiden.Approved
BoceprevirThe metabolism of Ivermectin can be decreased when combined with Boceprevir.Approved
BortezomibThe metabolism of Ivermectin can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Ivermectin can be decreased when it is combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Ivermectin.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Ivermectin.Approved
BromocriptineThe serum concentration of Ivermectin can be increased when it is combined with Bromocriptine.Approved, Investigational
BuprenorphineThe serum concentration of Ivermectin can be increased when it is combined with Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe serum concentration of Ivermectin can be increased when it is combined with Buspirone.Approved, Investigational
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Ivermectin.Approved
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Ivermectin.Approved
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Ivermectin.Experimental
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Ivermectin.Approved
CandesartanThe serum concentration of Ivermectin can be increased when it is combined with Candesartan.Approved
CaptoprilThe serum concentration of Ivermectin can be increased when it is combined with Captopril.Approved
CarbamazepineThe metabolism of Ivermectin can be increased when combined with Carbamazepine.Approved, Investigational
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Ivermectin.Approved
CarvedilolThe serum concentration of Ivermectin can be increased when it is combined with Carvedilol.Approved, Investigational
CaspofunginThe serum concentration of Ivermectin can be increased when it is combined with Caspofungin.Approved
CeritinibThe serum concentration of Ivermectin can be increased when it is combined with Ceritinib.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Ivermectin.Withdrawn
ChloroquineThe serum concentration of Ivermectin can be increased when it is combined with Chloroquine.Approved, Vet Approved
ChlorpromazineThe serum concentration of Ivermectin can be increased when it is combined with Chlorpromazine.Approved, Vet Approved
ChlorpropamideThe serum concentration of Ivermectin can be increased when it is combined with Chlorpropamide.Approved
ChlorprothixeneThe serum concentration of Ivermectin can be increased when it is combined with Chlorprothixene.Approved, Withdrawn
CholesterolThe serum concentration of Ivermectin can be increased when it is combined with Cholesterol.Experimental
Cholic AcidThe serum concentration of Ivermectin can be decreased when it is combined with Cholic Acid.Approved
CilazaprilThe serum concentration of Ivermectin can be increased when it is combined with Cilazapril.Approved
CimetidineThe serum concentration of Ivermectin can be decreased when it is combined with Cimetidine.Approved
CiprofloxacinThe serum concentration of Ivermectin can be increased when it is combined with Ciprofloxacin.Approved, Investigational
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Ivermectin.Approved
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Ivermectin.Approved
ClarithromycinThe metabolism of Ivermectin can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Ivermectin can be decreased when combined with Clemastine.Approved
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Ivermectin.Approved, Illicit
ClofazimineThe serum concentration of Ivermectin can be increased when it is combined with Clofazimine.Approved, Investigational
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Ivermectin.Approved, Investigational
ClomipramineThe serum concentration of Ivermectin can be increased when it is combined with Clomipramine.Approved, Vet Approved
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Ivermectin.Approved
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Ivermectin.Approved, Nutraceutical
ClotrimazoleThe metabolism of Ivermectin can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Ivermectin.Approved
CobicistatThe metabolism of Ivermectin can be decreased when combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Ivermectin.Approved
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Ivermectin.Approved
ColforsinThe serum concentration of Ivermectin can be increased when it is combined with Colforsin.Experimental
ConivaptanThe serum concentration of Ivermectin can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Ivermectin.Approved
CrizotinibThe metabolism of Ivermectin can be decreased when combined with Crizotinib.Approved
CyclophosphamideThe serum concentration of Ivermectin can be increased when it is combined with Cyclophosphamide.Approved, Investigational
CyclosporineThe metabolism of Ivermectin can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
Dabigatran etexilateThe serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Ivermectin.Approved
DabrafenibThe serum concentration of Ivermectin can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe serum concentration of Ivermectin can be increased when it is combined with Daclatasvir.Approved
DactinomycinThe serum concentration of Ivermectin can be increased when it is combined with Dactinomycin.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Ivermectin.Approved
DarunavirThe metabolism of Ivermectin can be decreased when combined with Darunavir.Approved
DasatinibThe serum concentration of Ivermectin can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinThe serum concentration of Ivermectin can be decreased when it is combined with Daunorubicin.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Ivermectin.Approved
DeferasiroxThe serum concentration of Ivermectin can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Ivermectin can be decreased when combined with Delavirdine.Approved
DesipramineThe serum concentration of Ivermectin can be increased when it is combined with Desipramine.Approved
DesloratadineThe serum concentration of Ivermectin can be increased when it is combined with Desloratadine.Approved, Investigational
DexamethasoneThe serum concentration of Ivermectin can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DextromethorphanThe serum concentration of Ivermectin can be increased when it is combined with Dextromethorphan.Approved
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Ivermectin.Approved, Illicit, Vet Approved
DiclofenacThe serum concentration of Ivermectin can be increased when it is combined with Diclofenac.Approved, Vet Approved
DicoumarolIvermectin may increase the anticoagulant activities of Dicoumarol.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Ivermectin.Approved
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Ivermectin.Approved
DigoxinThe serum concentration of Ivermectin can be decreased when it is combined with Digoxin.Approved
DihydroergotamineThe metabolism of Ivermectin can be decreased when combined with Dihydroergotamine.Approved
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Ivermectin.Illicit
DiltiazemThe metabolism of Ivermectin can be decreased when combined with Diltiazem.Approved
DipyridamoleThe serum concentration of Ivermectin can be increased when it is combined with Dipyridamole.Approved
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Ivermectin.Approved, Investigational
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Ivermectin.Approved, Investigational, Vet Approved
DoxazosinThe serum concentration of Ivermectin can be increased when it is combined with Doxazosin.Approved
DoxepinThe serum concentration of Ivermectin can be increased when it is combined with Doxepin.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Ivermectin.Approved, Investigational
DoxorubicinThe serum concentration of Ivermectin can be decreased when it is combined with Doxorubicin.Approved, Investigational
DoxycyclineThe metabolism of Ivermectin can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Ivermectin can be increased when it is combined with Dronabinol.Approved, Illicit
DronedaroneThe metabolism of Ivermectin can be decreased when combined with Dronedarone.Approved
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Ivermectin.Approved
EfavirenzThe serum concentration of Ivermectin can be decreased when it is combined with Efavirenz.Approved, Investigational
ElbasvirThe serum concentration of Ivermectin can be increased when it is combined with Elbasvir.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Ivermectin.Approved, Investigational
EltrombopagThe serum concentration of Ivermectin can be increased when it is combined with Eltrombopag.Approved
EnalaprilThe serum concentration of Ivermectin can be increased when it is combined with Enalapril.Approved, Vet Approved
EnzalutamideThe serum concentration of Ivermectin can be decreased when it is combined with Enzalutamide.Approved
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Ivermectin.Approved, Investigational
ErgonovineThe serum concentration of Ivermectin can be increased when it is combined with Ergonovine.Approved
ErgotamineThe serum concentration of Ivermectin can be increased when it is combined with Ergotamine.Approved
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Ivermectin.Approved, Investigational
ErythromycinThe metabolism of Ivermectin can be decreased when combined with Erythromycin.Approved, Vet Approved
Eslicarbazepine acetateThe serum concentration of Ivermectin can be decreased when it is combined with Eslicarbazepine acetate.Approved
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Ivermectin.Approved, Investigational, Vet Approved
EstramustineThe serum concentration of Ivermectin can be increased when it is combined with Estramustine.Approved
EstriolThe serum concentration of Ivermectin can be decreased when it is combined with Estriol.Approved, Vet Approved
EstroneThe serum concentration of Ivermectin can be decreased when it is combined with Estrone.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Ivermectin.Approved
Ethyl biscoumacetateIvermectin may increase the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
EtoposideThe serum concentration of Ivermectin can be increased when it is combined with Etoposide.Approved
EtravirineThe serum concentration of Ivermectin can be decreased when it is combined with Etravirine.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Ivermectin.Approved
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Ivermectin.Approved
FelodipineThe serum concentration of Ivermectin can be increased when it is combined with Felodipine.Approved, Investigational
FentanylThe serum concentration of Ivermectin can be increased when it is combined with Fentanyl.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Ivermectin.Approved
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Ivermectin.Approved
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Ivermectin.Approved
FluconazoleThe metabolism of Ivermectin can be decreased when combined with Fluconazole.Approved
FluindioneIvermectin may increase the anticoagulant activities of Fluindione.Investigational
FluoxetineThe serum concentration of Ivermectin can be increased when it is combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe serum concentration of Ivermectin can be increased when it is combined with Flupentixol.Approved, Withdrawn
FluphenazineThe serum concentration of Ivermectin can be increased when it is combined with Fluphenazine.Approved
FlurazepamThe serum concentration of Ivermectin can be increased when it is combined with Flurazepam.Approved, Illicit
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Ivermectin.Approved
FluvoxamineThe metabolism of Ivermectin can be decreased when combined with Fluvoxamine.Approved, Investigational
FosamprenavirThe metabolism of Ivermectin can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Ivermectin can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe metabolism of Ivermectin can be increased when combined with Fosphenytoin.Approved
Fusidic AcidThe serum concentration of Ivermectin can be increased when it is combined with Fusidic Acid.Approved
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Ivermectin.Approved, Investigational
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Ivermectin.Approved
GenisteinThe serum concentration of Ivermectin can be increased when it is combined with Genistein.Investigational
GlyburideThe serum concentration of Ivermectin can be increased when it is combined with Glyburide.Approved
GlycerolThe serum concentration of Ivermectin can be increased when it is combined with Glycerol.Experimental
Gramicidin DThe serum concentration of Ivermectin can be increased when it is combined with Gramicidin D.Approved
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Ivermectin.Approved
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Ivermectin.Withdrawn
HaloperidolThe serum concentration of Ivermectin can be increased when it is combined with Haloperidol.Approved
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Ivermectin.Approved, Vet Approved
HydroxychloroquineThe serum concentration of Ivermectin can be decreased when it is combined with Hydroxychloroquine.Approved
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Ivermectin.Approved
IdelalisibThe serum concentration of Ivermectin can be increased when it is combined with Idelalisib.Approved
ImatinibThe metabolism of Ivermectin can be decreased when combined with Imatinib.Approved
ImipramineThe serum concentration of Ivermectin can be increased when it is combined with Imipramine.Approved
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Ivermectin.Approved
IndinavirThe metabolism of Ivermectin can be decreased when combined with Indinavir.Approved
IndomethacinThe serum concentration of Ivermectin can be increased when it is combined with Indomethacin.Approved, Investigational
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Ivermectin.Approved, Investigational
IsavuconazoniumThe metabolism of Ivermectin can be decreased when combined with Isavuconazonium.Approved, Investigational
IsradipineThe metabolism of Ivermectin can be decreased when combined with Isradipine.Approved
ItraconazoleThe metabolism of Ivermectin can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Ivermectin can be increased when it is combined with Ivacaftor.Approved
KetamineThe serum concentration of Ivermectin can be increased when it is combined with Ketamine.Approved, Vet Approved
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Ivermectin.Approved
KetoconazoleThe metabolism of Ivermectin can be decreased when combined with Ketoconazole.Approved, Investigational
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Ivermectin.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Ivermectin.Approved, Investigational
LansoprazoleThe serum concentration of Ivermectin can be increased when it is combined with Lansoprazole.Approved, Investigational
LapatinibThe serum concentration of Ivermectin can be increased when it is combined with Lapatinib.Approved, Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Ivermectin.Approved
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Ivermectin.Approved
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Ivermectin.Approved
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Ivermectin.Approved, Investigational
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Ivermectin.Approved, Investigational
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Ivermectin.Approved
LevothyroxineThe serum concentration of Ivermectin can be decreased when it is combined with Levothyroxine.Approved
LidocaineThe serum concentration of Ivermectin can be increased when it is combined with Lidocaine.Approved, Vet Approved
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Ivermectin.Approved
LiothyronineThe serum concentration of Ivermectin can be decreased when it is combined with Liothyronine.Approved, Vet Approved
LiotrixThe serum concentration of Ivermectin can be decreased when it is combined with Liotrix.Approved
LisinoprilThe serum concentration of Ivermectin can be increased when it is combined with Lisinopril.Approved, Investigational
LomitapideThe serum concentration of Ivermectin can be increased when it is combined with Lomitapide.Approved
LoperamideThe serum concentration of Ivermectin can be increased when it is combined with Loperamide.Approved
LopinavirThe metabolism of Ivermectin can be decreased when combined with Lopinavir.Approved
LoratadineThe serum concentration of Ivermectin can be increased when it is combined with Loratadine.Approved
LosartanThe serum concentration of Ivermectin can be increased when it is combined with Losartan.Approved
LovastatinThe metabolism of Ivermectin can be decreased when combined with Lovastatin.Approved, Investigational
LuliconazoleThe serum concentration of Ivermectin can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Ivermectin can be decreased when it is combined with Lumacaftor.Approved
MannitolThe serum concentration of Mannitol can be increased when it is combined with Ivermectin.Approved, Investigational
MaprotilineThe serum concentration of Ivermectin can be increased when it is combined with Maprotiline.Approved
MebendazoleThe serum concentration of Ivermectin can be increased when it is combined with Mebendazole.Approved, Vet Approved
MefloquineThe serum concentration of Ivermectin can be increased when it is combined with Mefloquine.Approved
Megestrol acetateThe serum concentration of Ivermectin can be increased when it is combined with Megestrol acetate.Approved, Vet Approved
MeprobamateThe serum concentration of Ivermectin can be increased when it is combined with Meprobamate.Approved, Illicit
MethadoneThe serum concentration of Ivermectin can be increased when it is combined with Methadone.Approved
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Ivermectin.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Ivermectin.Approved, Vet Approved
MetoprololThe serum concentration of Ivermectin can be increased when it is combined with Metoprolol.Approved, Investigational
MibefradilThe serum concentration of Ivermectin can be increased when it is combined with Mibefradil.Withdrawn
MiconazoleThe serum concentration of Ivermectin can be increased when it is combined with Miconazole.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Ivermectin can be decreased when it is combined with Midazolam.Approved, Illicit
MifepristoneThe serum concentration of Ivermectin can be increased when it is combined with Mifepristone.Approved, Investigational
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Ivermectin.Approved
MitomycinThe serum concentration of Ivermectin can be increased when it is combined with Mitomycin.Approved
MitotaneThe serum concentration of Ivermectin can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Ivermectin can be decreased when it is combined with Mitoxantrone.Approved, Investigational
ModafinilThe serum concentration of Ivermectin can be decreased when it is combined with Modafinil.Approved, Investigational
MorphineThe serum concentration of Ivermectin can be increased when it is combined with Morphine.Approved, Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Ivermectin.Approved, Investigational
NadololThe serum concentration of Nadolol can be increased when it is combined with Ivermectin.Approved
NafcillinThe serum concentration of Ivermectin can be decreased when it is combined with Nafcillin.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Ivermectin.Approved
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Ivermectin.Approved, Vet Approved
NaltrexoneThe serum concentration of Ivermectin can be increased when it is combined with Naltrexone.Approved, Investigational, Vet Approved
NaringeninThe serum concentration of Ivermectin can be increased when it is combined with Naringenin.Experimental
NefazodoneThe metabolism of Ivermectin can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Ivermectin can be decreased when combined with Nelfinavir.Approved
NeostigmineThe serum concentration of Ivermectin can be increased when it is combined with Neostigmine.Approved, Vet Approved
NetupitantThe serum concentration of Ivermectin can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Ivermectin can be increased when combined with Nevirapine.Approved
NicardipineThe serum concentration of Ivermectin can be increased when it is combined with Nicardipine.Approved
NifedipineThe serum concentration of Ivermectin can be decreased when it is combined with Nifedipine.Approved
NilotinibThe metabolism of Ivermectin can be decreased when combined with Nilotinib.Approved, Investigational
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Ivermectin.Approved
NisoldipineThe serum concentration of Ivermectin can be increased when it is combined with Nisoldipine.Approved
NitrazepamThe serum concentration of Ivermectin can be increased when it is combined with Nitrazepam.Approved
NitrendipineThe serum concentration of Ivermectin can be increased when it is combined with Nitrendipine.Approved
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Ivermectin.Approved
NorethisteroneThe serum concentration of Ivermectin can be decreased when it is combined with Norethisterone.Approved
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Ivermectin.Approved, Investigational
OlaparibThe metabolism of Ivermectin can be decreased when combined with Olaparib.Approved
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Ivermectin.Approved
OmeprazoleThe serum concentration of Ivermectin can be increased when it is combined with Omeprazole.Approved, Investigational, Vet Approved
OsimertinibThe serum concentration of Ivermectin can be increased when it is combined with Osimertinib.Approved
P-NitrophenolThe serum concentration of Ivermectin can be increased when it is combined with P-Nitrophenol.Experimental
PaclitaxelThe serum concentration of Ivermectin can be increased when it is combined with Paclitaxel.Approved, Vet Approved
PalbociclibThe serum concentration of Ivermectin can be increased when it is combined with Palbociclib.Approved
Palmitic AcidThe serum concentration of Ivermectin can be increased when it is combined with Palmitic Acid.Experimental
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Ivermectin.Approved, Investigational
PantoprazoleThe serum concentration of Ivermectin can be increased when it is combined with Pantoprazole.Approved
ParoxetineThe serum concentration of Ivermectin can be increased when it is combined with Paroxetine.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Ivermectin.Approved
PentobarbitalThe metabolism of Ivermectin can be increased when combined with Pentobarbital.Approved, Vet Approved
PerindoprilThe serum concentration of Ivermectin can be increased when it is combined with Perindopril.Approved
PhenindioneIvermectin may increase the anticoagulant activities of Phenindione.Approved
PhenobarbitalThe metabolism of Ivermectin can be increased when combined with Phenobarbital.Approved
PhenprocoumonIvermectin may increase the anticoagulant activities of Phenprocoumon.Approved
PhenytoinThe metabolism of Ivermectin can be increased when combined with Phenytoin.Approved, Vet Approved
PimozideThe serum concentration of Ivermectin can be increased when it is combined with Pimozide.Approved
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Ivermectin.Approved
Platelet Activating FactorThe serum concentration of Ivermectin can be decreased when it is combined with Platelet Activating Factor.Experimental
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Ivermectin.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Ivermectin.Approved
PosaconazoleThe metabolism of Ivermectin can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Ivermectin.Approved
PrazosinThe serum concentration of Ivermectin can be increased when it is combined with Prazosin.Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Ivermectin.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Ivermectin.Approved, Vet Approved
PrimaquineThe serum concentration of Ivermectin can be decreased when it is combined with Primaquine.Approved
PrimidoneThe metabolism of Ivermectin can be increased when combined with Primidone.Approved, Vet Approved
ProbenecidThe serum concentration of Ivermectin can be increased when it is combined with Probenecid.Approved
ProgesteroneThe serum concentration of Ivermectin can be decreased when it is combined with Progesterone.Approved, Vet Approved
PromethazineThe serum concentration of Ivermectin can be increased when it is combined with Promethazine.Approved
PropafenoneThe serum concentration of Ivermectin can be increased when it is combined with Propafenone.Approved
PropranololThe serum concentration of Propranolol can be increased when it is combined with Ivermectin.Approved, Investigational
ProtriptylineThe serum concentration of Ivermectin can be increased when it is combined with Protriptyline.Approved
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Ivermectin.Approved
QuercetinThe serum concentration of Ivermectin can be increased when it is combined with Quercetin.Experimental
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Ivermectin.Approved
QuinacrineThe serum concentration of Ivermectin can be increased when it is combined with Quinacrine.Approved
QuinidineThe serum concentration of Ivermectin can be increased when it is combined with Quinidine.Approved
QuinineThe serum concentration of Ivermectin can be increased when it is combined with Quinine.Approved
RanitidineThe serum concentration of Ivermectin can be increased when it is combined with Ranitidine.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Ivermectin.Approved, Investigational
ReboxetineThe serum concentration of Ivermectin can be increased when it is combined with Reboxetine.Approved, Investigational
RegorafenibThe serum concentration of Ivermectin can be increased when it is combined with Regorafenib.Approved
ReserpineThe serum concentration of Ivermectin can be decreased when it is combined with Reserpine.Approved
RifabutinThe metabolism of Ivermectin can be increased when combined with Rifabutin.Approved
RifampicinThe metabolism of Ivermectin can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Ivermectin can be increased when combined with Rifapentine.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Ivermectin.Approved, Investigational
RilpivirineThe serum concentration of Ivermectin can be increased when it is combined with Rilpivirine.Approved
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Ivermectin.Approved, Investigational
RitonavirThe metabolism of Ivermectin can be decreased when combined with Ritonavir.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Ivermectin.Approved
RolapitantThe serum concentration of Ivermectin can be increased when it is combined with Rolapitant.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Ivermectin.Approved, Investigational
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Ivermectin.Approved, Vet Approved
SaquinavirThe metabolism of Ivermectin can be decreased when combined with Saquinavir.Approved, Investigational
ScopolamineThe serum concentration of Ivermectin can be increased when it is combined with Scopolamine.Approved
SelegilineThe serum concentration of Ivermectin can be increased when it is combined with Selegiline.Approved, Investigational, Vet Approved
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Ivermectin.Approved
SertralineThe serum concentration of Ivermectin can be increased when it is combined with Sertraline.Approved
SildenafilThe metabolism of Ivermectin can be decreased when combined with Sildenafil.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Ivermectin.Approved
SiltuximabThe serum concentration of Ivermectin can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Ivermectin can be increased when it is combined with Simeprevir.Approved
SimvastatinThe serum concentration of Ivermectin can be increased when it is combined with Simvastatin.Approved
SirolimusThe serum concentration of Ivermectin can be decreased when it is combined with Sirolimus.Approved, Investigational
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Ivermectin.Approved, Investigational
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Ivermectin.Approved
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Ivermectin.Approved, Investigational
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Ivermectin.Approved
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Ivermectin.Experimental
SpironolactoneThe serum concentration of Ivermectin can be increased when it is combined with Spironolactone.Approved
St. John's WortThe serum concentration of Ivermectin can be decreased when it is combined with St. John's Wort.Nutraceutical
StaurosporineThe serum concentration of Ivermectin can be increased when it is combined with Staurosporine.Experimental
StiripentolThe serum concentration of Ivermectin can be increased when it is combined with Stiripentol.Approved
StreptozocinThe serum concentration of Ivermectin can be decreased when it is combined with Streptozocin.Approved
SulfinpyrazoneThe serum concentration of Ivermectin can be increased when it is combined with Sulfinpyrazone.Approved
SulfisoxazoleThe metabolism of Ivermectin can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SumatriptanThe serum concentration of Ivermectin can be increased when it is combined with Sumatriptan.Approved, Investigational
SunitinibThe serum concentration of Ivermectin can be increased when it is combined with Sunitinib.Approved, Investigational
TacrineThe serum concentration of Ivermectin can be increased when it is combined with Tacrine.Withdrawn
TacrolimusThe serum concentration of Ivermectin can be decreased when it is combined with Tacrolimus.Approved, Investigational
TamoxifenThe serum concentration of Ivermectin can be decreased when it is combined with Tamoxifen.Approved
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Ivermectin.Experimental
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Ivermectin.Approved
TelaprevirThe metabolism of Ivermectin can be decreased when combined with Telaprevir.Approved
TelithromycinThe metabolism of Ivermectin can be decreased when combined with Telithromycin.Approved
TelmisartanThe serum concentration of Ivermectin can be increased when it is combined with Telmisartan.Approved, Investigational
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Ivermectin.Approved
TerazosinThe serum concentration of Ivermectin can be increased when it is combined with Terazosin.Approved
TerfenadineThe serum concentration of Ivermectin can be increased when it is combined with Terfenadine.Withdrawn
TeriflunomideThe serum concentration of Ivermectin can be increased when it is combined with Teriflunomide.Approved
TesmilifeneThe serum concentration of Ivermectin can be decreased when it is combined with Tesmilifene.Investigational
TestosteroneThe serum concentration of Ivermectin can be increased when it is combined with Testosterone.Approved, Investigational
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Ivermectin.Approved
TiclopidineThe metabolism of Ivermectin can be decreased when combined with Ticlopidine.Approved
TimololThe serum concentration of Timolol can be increased when it is combined with Ivermectin.Approved
TocilizumabThe serum concentration of Ivermectin can be decreased when it is combined with Tocilizumab.Approved
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Ivermectin.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Ivermectin.Approved, Investigational
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Ivermectin.Approved, Investigational
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Ivermectin.Approved
TrazodoneThe serum concentration of Ivermectin can be decreased when it is combined with Trazodone.Approved, Investigational
TrifluoperazineThe serum concentration of Ivermectin can be increased when it is combined with Trifluoperazine.Approved
TriflupromazineThe serum concentration of Ivermectin can be increased when it is combined with Triflupromazine.Approved, Vet Approved
TrimethoprimThe serum concentration of Ivermectin can be decreased when it is combined with Trimethoprim.Approved, Vet Approved
TrimipramineThe serum concentration of Ivermectin can be increased when it is combined with Trimipramine.Approved
TroleandomycinThe serum concentration of Ivermectin can be increased when it is combined with Troleandomycin.Approved
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Ivermectin.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Ivermectin.Approved
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Ivermectin.Approved
VenetoclaxThe serum concentration of Venetoclax can be increased when it is combined with Ivermectin.Approved
VenlafaxineThe metabolism of Ivermectin can be decreased when combined with Venlafaxine.Approved
VerapamilThe metabolism of Ivermectin can be decreased when combined with Verapamil.Approved
VinblastineThe serum concentration of Ivermectin can be decreased when it is combined with Vinblastine.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Ivermectin.Approved, Investigational
VincristineThe serum concentration of Ivermectin can be decreased when it is combined with Vincristine.Approved, Investigational
VinorelbineThe serum concentration of Ivermectin can be increased when it is combined with Vinorelbine.Approved, Investigational
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Ivermectin.Approved
VoriconazoleThe metabolism of Ivermectin can be decreased when combined with Voriconazole.Approved, Investigational
WarfarinIvermectin may increase the anticoagulant activities of Warfarin.Approved
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Ivermectin.Approved
ZimelidineThe serum concentration of Ivermectin can be increased when it is combined with Zimelidine.Withdrawn
ZiprasidoneThe metabolism of Ivermectin can be decreased when combined with Ziprasidone.Approved
Food Interactions
  • When administered with a high fat meal, the bioavailability is increased 2.5 times.
References
Synthesis Reference

Shuet-Hing L. Chiu, Josephine R. Carlin, Rae Taub, “Ivermectin derivative compounds and process for preparing the same.” U.S. Patent US4963667, issued June, 1982.

US4963667
General ReferencesNot Available
External Links
ATC CodesP02CF01D11AX22
AHFS Codes
  • 8:08
PDB EntriesNot Available
FDA labelDownload (60.2 KB)
MSDSDownload (73.4 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.8146
Blood Brain Barrier-0.549
Caco-2 permeable-0.8192
P-glycoprotein substrateSubstrate0.8771
P-glycoprotein inhibitor IInhibitor0.805
P-glycoprotein inhibitor IIInhibitor0.8192
Renal organic cation transporterNon-inhibitor0.7384
CYP450 2C9 substrateNon-substrate0.8877
CYP450 2D6 substrateNon-substrate0.886
CYP450 3A4 substrateSubstrate0.7714
CYP450 1A2 substrateNon-inhibitor0.9129
CYP450 2C9 inhibitorNon-inhibitor0.8366
CYP450 2D6 inhibitorNon-inhibitor0.928
CYP450 2C19 inhibitorNon-inhibitor0.8793
CYP450 3A4 inhibitorNon-inhibitor0.7957
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8073
Ames testNon AMES toxic0.8295
CarcinogenicityNon-carcinogens0.9622
BiodegradationNot ready biodegradable0.9759
Rat acute toxicity3.5285 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9471
hERG inhibition (predictor II)Non-inhibitor0.5536
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Merck and co inc
Packagers
Dosage forms
FormRouteStrength
CreamTopical1 %
LotionTopical.585 g/117g
LotionTopical5 mg/g
CreamTopical10 mg/g
TabletOral3 mg/1
Prices
Unit descriptionCostUnit
Stromectol 20 3 mg tablet Box116.13USD box
Ivermectin powder14.0USD g
Stromectol 3 mg tablet5.58USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5952372 No1998-09-182018-09-18Us
US6103248 No1998-05-222018-05-22Us
US6133310 No1999-04-262019-04-26Us
US7550440 No2004-04-222024-04-22Us
US8080530 No2004-04-222024-04-22Us
US8093219 No2004-04-222024-04-22Us
US8415311 No2004-04-222024-04-22Us
US8470788 No2004-04-222024-04-22Us
US8791153 No2007-10-122027-10-12Us
US8815816 No2004-04-222024-04-22Us
US8927595 No2007-10-122027-10-12Us
US9089587 No2014-03-132034-03-13Us
US9233117 No2014-03-132034-03-13Us
US9233118 No2014-03-132034-03-13Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point155 °CNot Available
water solubilityInsolubleNot Available
Predicted Properties
PropertyValueSource
logP5.83ChemAxon
pKa (Strongest Acidic)12.47ChemAxon
pKa (Strongest Basic)-3.4ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count13ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area170.06 Å2ChemAxon
Rotatable Bond Count15ChemAxon
Refractivity230.33 m3·mol-1ChemAxon
Polarizability96.87 Å3ChemAxon
Number of Rings14ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as macrolides and analogues. These are organic compounds containing a lactone ring of at least twelve members.
KingdomOrganic compounds
Super ClassPhenylpropanoids and polyketides
ClassMacrolides and analogues
Sub ClassNot Available
Direct ParentMacrolides and analogues
Alternative Parents
Substituents
  • Macrolide
  • Oxane
  • Monosaccharide
  • Saccharide
  • Tertiary alcohol
  • Oxolane
  • Secondary alcohol
  • Lactone
  • Carboxylic acid ester
  • Oxacycle
  • Organoheterocyclic compound
  • Monocarboxylic acid or derivatives
  • Ether
  • Dialkyl ether
  • Carboxylic acid derivative
  • Acetal
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Alcohol
  • Aliphatic heteropolycyclic compound
Molecular FrameworkNot Available
External DescriptorsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Gaba-gated chloride ion channel activity
Specific Function:
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
Gene Name:
GABRB3
Uniprot ID:
P28472
Molecular Weight:
54115.04 Da
References
  1. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  2. Feng XP, Hayashi J, Beech RN, Prichard RK: Study of the nematode putative GABA type-A receptor subunits: evidence for modulation by ivermectin. J Neurochem. 2002 Nov;83(4):870-8. [PubMed:12421359 ]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Transmitter-gated ion channel activity
Specific Function:
The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
Gene Name:
GLRA3
Uniprot ID:
O75311
Molecular Weight:
53799.775 Da
References
  1. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  2. Yates DM, Wolstenholme AJ: An ivermectin-sensitive glutamate-gated chloride channel subunit from Dirofilaria immitis. Int J Parasitol. 2004 Aug;34(9):1075-81. [PubMed:15313134 ]
  3. McCavera S, Rogers AT, Yates DM, Woods DJ, Wolstenholme AJ: An ivermectin-sensitive glutamate-gated chloride channel from the parasitic nematode Haemonchus contortus. Mol Pharmacol. 2009 Jun;75(6):1347-55. doi: 10.1124/mol.108.053363. Epub 2009 Mar 31. [PubMed:19336526 ]
  4. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. [PubMed:12699389 ]
  2. Pouliot JF, L'Heureux F, Liu Z, Prichard RK, Georges E: Reversal of P-glycoprotein-associated multidrug resistance by ivermectin. Biochem Pharmacol. 1997 Jan 10;53(1):17-25. [PubMed:8960059 ]
  3. Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. [PubMed:14985103 ]
  4. Schinkel AH, Wagenaar E, van Deemter L, Mol CA, Borst P: Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. J Clin Invest. 1995 Oct;96(4):1698-705. [PubMed:7560060 ]
  5. Jani M, Makai I, Kis E, Szabo P, Nagy T, Krajcsi P, Lespine A: Ivermectin interacts with human ABCG2. J Pharm Sci. 2011 Jan;100(1):94-7. doi: 10.1002/jps.22262. Epub 2010 Jun 22. [PubMed:20574995 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Transporter activity
Specific Function:
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
Gene Name:
ABCC1
Uniprot ID:
P33527
Molecular Weight:
171589.5 Da
References
  1. Lespine A, Dupuy J, Orlowski S, Nagy T, Glavinas H, Krajcsi P, Alvinerie M: Interaction of ivermectin with multidrug resistance proteins (MRP1, 2 and 3). Chem Biol Interact. 2006 Feb 25;159(3):169-79. Epub 2005 Dec 27. [PubMed:16384552 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Organic anion transmembrane transporter activity
Specific Function:
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Gene Name:
ABCC2
Uniprot ID:
Q92887
Molecular Weight:
174205.64 Da
References
  1. Lespine A, Dupuy J, Orlowski S, Nagy T, Glavinas H, Krajcsi P, Alvinerie M: Interaction of ivermectin with multidrug resistance proteins (MRP1, 2 and 3). Chem Biol Interact. 2006 Feb 25;159(3):169-79. Epub 2005 Dec 27. [PubMed:16384552 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from t...
Gene Name:
ABCG2
Uniprot ID:
Q9UNQ0
Molecular Weight:
72313.47 Da
References
  1. Jani M, Makai I, Kis E, Szabo P, Nagy T, Krajcsi P, Lespine A: Ivermectin interacts with human ABCG2. J Pharm Sci. 2011 Jan;100(1):94-7. doi: 10.1002/jps.22262. Epub 2010 Jun 22. [PubMed:20574995 ]
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Drug created on June 13, 2005 07:24 / Updated on December 03, 2016 02:47