Folic Acid and Derivatives

Name
Folic Acid and Derivatives
Accession Number
DBCAT001033  (DBCAT001031, DBCAT001032, DBCAT002079, DBCAT002146, DBCAT002158, DBCAT003386)
Description

A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (POACEAE). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia.

ATC Classification
Drugs
DrugDrug Description
Tetrahydrofolic acidFor nutritional supplementation, also for treating dietary shortage or imbalance.
LeucovorinA folate analog used to treat the toxic effects of methotrexate and other folate antagonists, to treat megaloblastic anemia, and to provide palliative treatment of colorectal cancer.
LevoleucovorinA folate analog used after high dose methotrexate for osteosarcoma, to reduce the toxic effects of folate analogs, and with 5-fluorouracil in palliative treatment of advanced metastatic colorectal cancer.
Folic acidA nutrient used to treat megaloblastic anemia and is found in many supplements.
Levomefolic acidA folate supplement used to prevent neural tube defects in pregnancy or folate deficiency.
Triglu-5-formyl-tetrahydrofolateNot Available
(6S)-5,6,7,8-tetrahydrofolic acidNot Available
5-methyltetrahydrofolic acid5-methyltetrahydrofolic acid is a methylated derivate of tetrahydrofolate. It is generated by methylenetetrahydrofolate reductase from 5,10-methylenetetrahydrofolate and used to recycle homocysteine back to methionine by 5-methyltetrahydrofolate-homocysteine methyltransferases (also called methionine...
(6R)-Folinic acidNot Available
Drugs & Drug Targets
DrugTargetType
Tetrahydrofolic acidC-1-tetrahydrofolate synthase, cytoplasmictarget
Tetrahydrofolic acidBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrialtarget
Tetrahydrofolic acidAminomethyltransferase, mitochondrialtarget
Tetrahydrofolic acidCytosolic 10-formyltetrahydrofolate dehydrogenasetarget
Tetrahydrofolic acidMethionine synthasetarget
Tetrahydrofolic acidFormimidoyltransferase-cyclodeaminasetarget
Tetrahydrofolic acidBifunctional purine biosynthesis protein PURHtarget
Tetrahydrofolic acidSerine hydroxymethyltransferase, cytosolictarget
Tetrahydrofolic acidSerine hydroxymethyltransferase, mitochondrialtarget
Tetrahydrofolic acidMethylenetetrahydrofolate reductasetarget
Tetrahydrofolic acidSerine hydroxymethyltransferasetarget
Tetrahydrofolic acidMethionyl-tRNA formyltransferase, mitochondrialtarget
Tetrahydrofolic acidCanalicular multispecific organic anion transporter 1transporter
LeucovorinSolute carrier family 22 member 8transporter
LevoleucovorinSerine hydroxymethyltransferasetarget
Folic acidFolate receptor gammatarget
Folic acidFolate receptor betatarget
Folic acidMethylenetetrahydrofolate reductaseenzyme
Folic acidMultidrug resistance-associated protein 4transporter
Folic acidSolute carrier family 22 member 6transporter
Folic acidCanalicular multispecific organic anion transporter 2transporter
Folic acidATP-binding cassette sub-family C member 11transporter
Folic acidATP-binding cassette sub-family G member 2transporter
Folic acidProton-coupled folate transportertransporter
Folic acidMitochondrial folate transporter/carriertransporter
Folic acidGamma-glutamyl hydrolaseenzyme
Folic acidFolate receptor alphatarget
Folic acidDihydrofolate reductaseenzyme
Levomefolic acidProton-coupled folate transportertransporter
Levomefolic acidFolate transporter 1transporter
Levomefolic acidMethionine synthaseenzyme
Triglu-5-formyl-tetrahydrofolateSerine hydroxymethyltransferase, cytosolictarget
(6S)-5,6,7,8-tetrahydrofolic acidNitric oxide synthase oxygenasetarget
(6S)-5,6,7,8-tetrahydrofolic acidThymidylate synthasetarget
5-methyltetrahydrofolic acidAminomethyltransferase, mitochondrialtarget
5-methyltetrahydrofolic acidCanalicular multispecific organic anion transporter 1transporter
(6R)-Folinic acidSerine hydroxymethyltransferasetarget
(6R)-Folinic acidAminomethyltransferasetarget
(6R)-Folinic acidBifunctional polymyxin resistance protein ArnAtarget
(6R)-Folinic acidFormimidoyltransferase-cyclodeaminasetarget
(6R)-Folinic acidN,N-dimethylglycine oxidasetarget