Folic Acid and Derivatives

A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (POACEAE). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia.
DrugDrug NameDrug Indication
DB00116Tetrahydrofolic acidFor nutritional supplementation, also for treating dietary shortage or imbalance.
DB00650LeucovorinFor the treatment of osteosarcoma (after high dose methotrexate therapy). Used to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosages of folic acid antagonists, and to treat megaloblastic anemias due to folic acid deficiency. Also used in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer.
DB11596LevoleucovorinLevoleucovorin is indicated for use as rescue therapy following high-dose methotrexate in the treatment of osteosarcoma or for diminishing the toxicity associated with inadvertent overdosage of folic acid antagonists. Levoleucovorin, as the product Fusilev (FDA, dosed at one-half the usual dose of racemic d,l-leucovorin), has an additional indication for use in combination chemotherapy with 5-fluorouracil in the palliative treatment of patients with advanced metastatic colorectal cancer (although they should not be mixed in the same infusion as a precipitate may form).
DB00158Folic AcidFor treatment of folic acid deficiency, megaloblastic anemia and in anemias of nutritional supplements, pregnancy, infancy, or childhood.
DB11256Levomefolic acidFor the treatment and prevention of folate deficiency and for use as an antidote against folic acid antagonists. Contained in oral contraceptives to reduce the risk of neural tube defects arising from folic acid deficiency for pregnant women who conceived during use or shortly after the discontinuation of the product. Being studied for use as a treatment for cardiovascular diseases [A19273] and adjunct therapy for patients undergoing antidepressant pharmacotherapy [A19271, A19272].
DB02067Triglu-5-Formyl-TetrahydrofolateNot Available
DB02031(6S)-5,6,7,8-tetrahydrofolateNot Available
DB047895-methyltetrahydrofolic acidNot Available
DB03256(6R)-Folinic acidNot Available
DrugDrug NameTargetType
DB00116Tetrahydrofolic acidC-1-tetrahydrofolate synthase, cytoplasmictarget
DB00116Tetrahydrofolic acidBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrialtarget
DB00116Tetrahydrofolic acidAminomethyltransferase, mitochondrialtarget
DB00116Tetrahydrofolic acidCytosolic 10-formyltetrahydrofolate dehydrogenasetarget
DB00116Tetrahydrofolic acidMethionine synthasetarget
DB00116Tetrahydrofolic acidFormimidoyltransferase-cyclodeaminasetarget
DB00116Tetrahydrofolic acidBifunctional purine biosynthesis protein PURHtarget
DB00116Tetrahydrofolic acidSerine hydroxymethyltransferase, cytosolictarget
DB00116Tetrahydrofolic acidSerine hydroxymethyltransferase, mitochondrialtarget
DB00116Tetrahydrofolic acidMethylenetetrahydrofolate reductasetarget
DB00116Tetrahydrofolic acidSerine hydroxymethyltransferasetarget
DB00116Tetrahydrofolic acidMethionyl-tRNA formyltransferase, mitochondrialtarget
DB00116Tetrahydrofolic acidCanalicular multispecific organic anion transporter 1transporter
DB00650LeucovorinSolute carrier family 22 member 8transporter
DB11596LevoleucovorinSerine hydroxymethyltransferasetarget
DB11596LevoleucovorinDihydrofolate reductasetarget
DB00158Folic AcidSerum albumincarrier
DB00158Folic AcidMethylenetetrahydrofolate reductaseenzyme
DB00158Folic AcidCytochrome P450 2E1enzyme
DB00158Folic AcidGamma-glutamyl hydrolaseenzyme
DB00158Folic AcidFolate receptor gammatarget
DB00158Folic AcidFolate receptor betatarget
DB00158Folic AcidFolate receptor alphatarget
DB00158Folic AcidMultidrug resistance-associated protein 4transporter
DB00158Folic AcidSolute carrier family 22 member 6transporter
DB00158Folic AcidCanalicular multispecific organic anion transporter 2transporter
DB00158Folic AcidATP-binding cassette sub-family C member 11transporter
DB00158Folic AcidATP-binding cassette sub-family G member 2transporter
DB00158Folic AcidProton-coupled folate transportertransporter
DB00158Folic AcidMitochondrial folate transporter/carriertransporter
DB11256Levomefolic acidMethionine synthaseenzyme
DB11256Levomefolic acidProton-coupled folate transportertransporter
DB11256Levomefolic acidFolate transporter 1transporter
DB02067Triglu-5-Formyl-TetrahydrofolateSerine hydroxymethyltransferase, cytosolictarget
DB02031(6S)-5,6,7,8-tetrahydrofolateNitric oxide synthase oxygenasetarget
DB02031(6S)-5,6,7,8-tetrahydrofolateThymidylate synthasetarget
DB047895-methyltetrahydrofolic acidAminomethyltransferase, mitochondrialtarget
DB047895-methyltetrahydrofolic acidCanalicular multispecific organic anion transporter 1transporter
DB03256(6R)-Folinic acidSerine hydroxymethyltransferasetarget
DB03256(6R)-Folinic acidAminomethyltransferasetarget
DB03256(6R)-Folinic acidBifunctional polymyxin resistance protein ArnAtarget
DB03256(6R)-Folinic acidFormimidoyltransferase-cyclodeaminasetarget
DB03256(6R)-Folinic acidN,N-dimethylglycine oxidasetarget