Folic Acid

Identification

Name
Folic Acid
Accession Number
DB00158  (NUTR00025)
Type
Small Molecule
Groups
Approved, Nutraceutical, Vet Approved
Description

A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (poaceae). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia. [PubChem]

Structure
Thumb
Synonyms
  • Folacin
  • Folate
  • Folic acid
  • Folsaeure
  • N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
  • N-Pteroyl-L-glutamic acid
  • PGA
  • PteGlu
  • Pteroyl-L-glutamate
  • Pteroyl-L-glutamic acid
  • Pteroyl-L-monoglutamic acid
  • Pteroylglutamic acid
  • Vitamin B9
  • Vitamin Bc
  • Vitamin M
External IDs
B03BB01 / NSC-3073
Product Ingredients
IngredientUNIICASInChI Key
Folate sodium9P9W8GGU78 6484-89-5SWIRFWUEJODNRG-CURYUGHLSA-L
Product Images
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Acide Folique 5 TabTablet5 mgOralPro Doc Limitee1982-12-312010-07-13Canada
Euro-folic 5mgTablet5 mgOralSandoz Canada Incorporated2006-11-27Not applicableCanada
Folic AcidTablet1 mg/1OralApace Packaging2009-12-23Not applicableUs
Folic Acid 0.4mgTablet0.4 mgOralLeiner Health ProductsNot applicableNot applicableCanada
Folic Acid Inj 5mg/ml USPLiquid5 mgIntramuscular; Intravenous; SubcutaneousLyphomed, Division Of Fujisawa Canada Inc.1993-12-311996-09-10Canada
Folic Acid InjectionSolution5 mgIntramuscular; Intravenous; SubcutaneousFresenius Kabi1996-08-14Not applicableCanada
Folic Acid Injection USPLiquid5 mgIntramuscular; Intravenous; SubcutaneousSandoz Canada Incorporated1990-12-31Not applicableCanada
Folic Acid Tab 25mgTablet25 mgOralKripps Pharmacy Ltd.1975-12-31Not applicableCanada
Folic Acid Tab 5mgTablet5 mgOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1957-12-312002-07-31Canada
Folic Acid Tab 5mgTablet5 mgOralPendopharm Division Of De Pharmascience Inc1980-12-31Not applicableCanada
Folic Acid Tab 5mgTablet5 mgOralEverest Pharmaceuticals Ltd.1980-12-311999-07-14Canada
Folic Acid Tab 5mgTablet5 mgOralIcn Pharmaceuticals1974-12-312005-04-26Canada
Folic Acid Tab 5mgTablet5 mgOralKripps Pharmacy Ltd.1975-12-311997-08-01Canada
Folic Acid Tablets 5mgTablet5 mgOralD.C. Labs Limited1969-12-312003-07-11Canada
FolviteTablet5 mgOralOrimed Pharma CorporationNot applicableNot applicableCanada
Folvite Inj 5mg/mlLiquid5 mgIntramuscular; Intravenous; SubcutaneousLederle Cyanamid Canada Inc.1951-12-312000-08-02Canada
Folvite Tab 5mgTablet5 mgOralLederle Cyanamid Canada Inc.1951-12-311999-04-12Canada
Jamp-folic AcidTablet5 mgOralJamp Pharma Corporation2011-06-10Not applicableCanada
Novo-folacid 5mgTablet5 mgOralNovopharm Limited1967-12-312015-10-26Canada
Nu-folicTablet5 mgOralNu Pharm IncNot applicableNot applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo Folic Acid Tab 5mgTablet5 mgOralApotex Corporation1978-12-31Not applicableCanada
Folic AcidTablet1 mg/1OralMarlex Pharmaceuticals Inc2016-02-01Not applicableUs
Folic AcidTablet1 mg/1OralA S Medication Solutions2009-01-122017-06-20Us
Folic AcidTablet1 mg/1OralQualitest1972-03-312015-12-29Us
Folic AcidTablet1 mg/1OralNucare Pharmaceuticals, Inc.2009-01-12Not applicableUs
Folic AcidTablet1 mg/1OralRemedy Repack2011-08-102016-11-04Us
Folic AcidTablet1 mg/1OralRemedy Repack2012-08-162016-10-13Us
Folic AcidTablet1 mg/1Oralbryant ranch prepack2009-12-02Not applicableUs
Folic AcidTablet1 mg/1OralRemedy Repack2016-02-19Not applicableUs
Folic AcidTablet1 mg/1OralMethod Pharmaceuticals2015-03-01Not applicableUs
Folic AcidTablet1 mg/1OralExcellium Pharmaceutical, Inc.2009-06-01Not applicableUs
Folic AcidTablet1 mg/1OralWest Ward Pharmaceutical2009-06-09Not applicableUs
Folic AcidTablet1 mg/1OralClinical Solutions Wholsesale2010-06-042017-06-27Us
Folic AcidTablet1 mg/1OralMc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation2011-10-17Not applicableUs00603 3162 32 nlmimage10 163f0b08
Folic AcidTablet1 mg/1OralCadila Pharnmaceuticals2014-01-302017-05-27Us
Folic AcidTablet1 mg/1OralBlu Pharmceuticals Llc2010-11-012017-05-11Us
Folic AcidInjection, solution5 mg/mLIntramuscular; Intravenous; SubcutaneousFresenius Kabi2000-09-05Not applicableUs
Folic AcidTablet1 mg/1OralPreferreed Pharmaceuticals Inc.2014-04-14Not applicableUs65162 0361 10 nlmimage10 0823842c
Folic AcidTablet1 mg/1OralMajor2009-12-02Not applicableUs
Folic AcidTablet1 mg/1OralAmerincan Health Packaging2009-08-15Not applicableUs
Folic AcidTablet1 mg/1OralMylan Institutional2011-04-21Not applicableUs
Folic AcidTablet1 mg/1OralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs
Folic AcidTablet1 mg/1OralRemedy Repack2017-07-06Not applicableUs
Folic AcidTablet1 mg/1OralNucare Pharmaceuticals, Inc.2015-03-01Not applicableUs
Folic AcidTablet1 mg/1OralA S Medication Solutions2010-06-04Not applicableUs
Folic AcidTablet1 mg/1OralCardinal Health2009-12-02Not applicableUs
Folic AcidTablet1 mg/1OralRemedy Repack2013-02-282017-11-14Us64125 0127 10 nlmimage10 a23b510a
Folic AcidTablet1 mg/1OralMc Kesson Contract Packaging2012-03-05Not applicableUs00143 9717 10 nlmimage10 9807cc5e
Folic AcidTablet1 mg/1OralAphena Pharma Solutions Tennessee, Inc.2010-04-06Not applicableUs
Folic AcidTablet1 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2009-12-02Not applicableUs
Folic AcidTablet1 mg/1OralRemedy Repack2012-08-27Not applicableUs
Folic AcidTablet1 mg/1OralA S Medication Solutions2010-06-042017-06-20Us
Folic AcidTablet1 mg/1OralPreferreed Pharmaceuticals Inc.2012-04-30Not applicableUs
Folic AcidTablet1 mg/1OralAv Pak2005-07-22Not applicableUs
Folic AcidTablet1 mg/1OralRemedy Repack2013-05-092017-01-18Us
Folic AcidTablet1 mg/1OralPar Pharmaceutical2010-06-04Not applicableUs
Folic AcidTablet1 mg/1OralMethod Pharmaceuticals2016-02-09Not applicableUs
Folic AcidTablet1 mg/1OralSt. Marys Medical Park Pharmacy2013-05-09Not applicableUs
Folic AcidTablet1 mg/1OralTYA Pharmaceuticals2009-12-02Not applicableUs
Folic AcidTablet1 mg/1OralA S Medication Solutions2009-06-092017-06-20Us
Folic AcidTablet1 mg/1OralRemedy Repack2010-03-30Not applicableUs
Folic AcidTablet1 mg/1OralContract Pharmacy Services Pa2010-04-13Not applicableUs
Folic AcidTablet1 mg/1OralAidarex Pharmaceuticals LLC2009-06-09Not applicableUs
Folic AcidTablet1 mg/1OralPreferreed Pharmaceuticals Inc.2017-04-24Not applicableUs
Folic AcidTablet1 mg/1OralA S Medication Solutions2009-06-01Not applicableUs
Folic AcidTablet1 mg/1OralSafecor Health, LLC2014-09-30Not applicableUs
Folic AcidTablet1 mg/1OralCadila Pharnmaceuticals2017-03-24Not applicableUs
Folic AcidTablet1 mg/1OralRemedy Repack2016-08-01Not applicableUs
Folic AcidTablet1 mg/1OralPd Rx Pharmaceuticals, Inc.2009-12-02Not applicableUs
Folic AcidTablet1 mg/1OralLake Erie Medical Dba Quality Care Produts Llc2010-06-04Not applicableUs
Folic AcidTablet1 mg/1OralExelan Pharmaceuticals, Inc.2010-04-06Not applicableUs
Folic AcidTablet1 mg/1OralLeading Pharma, Llc2009-01-12Not applicableUs
Folic AcidTablet1 mg/1OralMc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation2004-11-24Not applicableUs
Folic AcidTablet1 mg/1OralAmneal Pharmaceuticals of New York Llc2009-12-02Not applicableUs
Folic AcidTablet1 mg/1OralSunrise Pharmaceutical, Inc.2015-08-04Not applicableUs
Folic AcidTablet1 mg/1OralRemedy Repack2013-08-16Not applicableUs
Folic AcidTablet1 mg/1Oralbryant ranch prepack2009-12-02Not applicableUs
Folic AcidTablet1 mg/1OralCentral Texas Community Health Centers2010-06-04Not applicableUs
Folic AcidTablet1 mg/1OralClinical Solutions Wholsesale2009-01-12Not applicableUs
Folic AcidTablet1 mg/1OralUnit Dose Services2009-12-02Not applicableUs
Folic AcidTablet1 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Folic AcidTablet1 mg/1OralClinical Solutions Wholsesale2009-06-012017-07-01Us
Folic AcidTablet1 mg/1OralCardinal Health2010-06-042017-04-25Us
Folic AcidTablet1 mg/1OralCardinal Health2009-12-21Not applicableUs
Folic AcidTablet1 mg/1OralContract Pharmacy Services Pa2010-11-09Not applicableUs
Folic AcidTablet1 mg/1OralAphena Pharma Solutions Tennessee, Inc.2010-06-04Not applicableUs
Folic AcidTablet1 mg/1OralCardinal Health2011-05-20Not applicableUs
Folic AcidTablet1 mg/1OralAi Ping Pharmaceutical, Inc.2013-07-18Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Folic AcidCapsule1 mgOralSisu Inc.1999-08-032006-07-31Canada
Folic Acid (1mg Tablet)Tablet1 mgOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1997-10-102002-07-31Canada
Folic Acid 0.4 Mg TabletTablet0.4 mgOralSwiss Herbal Remedies Ltd.1999-12-062007-07-31Canada
Folic Acid 0.4mgTablet0.4 mgOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Folic Acid 0.4mg Dietary SupplementTablet0.4 mgOralGarden State Nutritionals1998-08-312000-06-07Canada
Folic Acid 0.8mgTablet0.8 mgOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Folic Acid 1 mgTablet1 mgOralPreferred Nutrition Inc.2004-04-282005-08-04Canada
Folic Acid 1 Mg - TabletTablet1 mgOralHealth Wise Nutrition Inc.1996-10-222002-07-18Canada
Folic Acid 1mgTablet1.0 mgOralWn Pharmaceuticals Ltd.2002-04-152006-08-08Canada
Folic Acid 1mgTablet1 mgOralJamieson Laboratories Ltd1994-12-311997-08-13Canada
Folic Acid 400mcg TabTablet.4 mgOralNatrol, Inc.1994-12-311999-08-10Canada
Folic Acid 800mcg TabTablet.8 mgOralNatrol, Inc.1994-12-312002-09-03Canada
Folic Acid Capsules 1mgCapsule1 mgOralFinlandia Consultants1990-12-311997-12-02Canada
Folic Acid Ctr Srt 800mcgTablet, extended release800 mcgOralBioenergy Inc.1979-12-311998-06-03Canada
Folic Acid Tab 0.4mg USPTablet.4 mgOralPharmavite1987-12-311999-08-10Canada
Folic Acid Tab 1mgTablet1 mgOralSwiss Herbal Remedies Ltd.1986-12-312007-07-31Canada
Folic Acid Tab 1mg USP ChewableTablet1 mgOralLab Gernetic Int Ltee1985-12-311997-02-21Canada
Folic Acid Tablets 0.8mgTablet0.8 mgOralRoyal Bodycare Canada Inc.1992-12-312001-08-07Canada
NatafolikTablet1 mgOralLe Groupe M. Vachon Inc.1996-10-302001-08-07Canada
Unapproved/Other Products
Not Available
International/Other Brands
Acfol (Cazi) / Fefol (GlaxoSmithKline)
Brand mixtures
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
A.R.T.H. Away FormulaCapsuleOralAbundance Marketing Ltd.1999-02-012006-06-16Canada
Acti-folic + Dibencozide CapletsTabletOralActi Form Ltd.1991-12-312005-03-21Canada
Active FETabletOralGm Pharmaceuticals2013-11-11Not applicableUs
Adult Infuvite Multiple VitaminsInjection, solutionIntravenousSandoz2005-05-18Not applicableUs
Am CapsCapsuleOralNew Vision Nutritionals Company1998-10-012002-11-20Canada
Animi-3CapsuleOralPbm Pharmaceuticals Inc.2011-06-01Not applicableUs
Animi-3 with Vitamin DCapsuleOralPbm Pharmaceuticals Inc.2011-06-01Not applicableUs
Av-VITE FBTabletOralAv Kare, Inc.2015-11-052016-01-20Us
B 50 CapsulesCapsuleOralRheingold Food International Ltd.1987-12-312007-07-26Canada
B Complex 25mg Vitamin SupplementTabletOralGarden State Nutritionals1998-08-312000-06-07Canada
B Complex 50 Vitamin CapCapsuleOralBioforce Canada Inc.1994-12-311997-07-22Canada
B Complex 50+ CapletTabletOralHealth Wise Nutrition Inc.1994-12-312002-07-18Canada
B Complex TabletsTabletOralGolden Neo Life Diamite International, Limited1979-12-312000-08-06Canada
B Compound 50mg TabTabletOralGahler Enterprises Ltd.1987-12-312009-09-28Canada
B Stress C + Iron & ViteTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1990-12-312004-07-26Canada
B-100 CapsCapsuleOralNow Foods2005-05-192008-07-11Canada
B-100 Complex TabletsTablet, extended releaseOralViva Pharmaceutical Inc.2001-06-052009-12-18Canada
B-100 Hi Potency B Vitamins TabTabletOralNatrol, Inc.1994-12-312009-05-07Canada
B-100 Vitamin SupplementTablet, extended releaseOralGarden State Nutritionals1998-09-222000-06-07Canada
B-50 ComplexTabletOralVita Health Products Inc1977-12-312004-07-26Canada
B-50 Complex TabTabletOralVita Health Products Inc1988-12-311998-07-22Canada
B-50 Hi Potency B Vitamins TabTabletOralNatrol, Inc.1994-12-312006-09-26Canada
B-complexTabletOralEnrich International1999-11-112001-09-28Canada
B-complex 100TabletOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
B-complex 50TabletOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
B-complex TabTabletOralNatures Sunshine Products, Inc.1995-12-312009-08-07Canada
B-complex TabletsTabletOralShaklee Corporation1983-12-312000-01-24Canada
B-complex With Vitamin C, Biotin, Folic AcidTabletOralWn Pharmaceuticals Ltd.2001-11-232009-09-28Canada
B-complex-50 TabTabletOralJr Carlson Labs Inc1998-10-252005-09-15Canada
B-NexaTabletOralUpsher Smith Laboratories2011-12-08Not applicableUs
B-plexTabletOralWn Pharmaceuticals Ltd.1999-10-202000-01-28Canada
B50 B Complex TabTabletOralNutristar Health Products (1987) Inc.1983-12-311996-09-09Canada
B6, B12 & Folic AcidCapsuleOralNatural Factors Nutritional Products Ltd.2001-12-192009-09-28Canada
B6, B12 & Folic Acid Multi-vitamin TabletsTabletOralWampole Brands2000-02-242009-06-19Canada
BacminTablet, coatedOralMarnel Pharmaceuticals, Llc2000-04-01Not applicableUs
Balanced B 125 SrtTablet, extended releaseOralAnabolic Laboratories Inc.1981-12-311996-10-02Canada
Balanced B-100 B-complex Vitamins TabTabletOralPharmavite1991-12-312003-07-30Canada
Balanced B-100 Timed ReleaseTabletOralPharmavite2000-10-242005-07-15Canada
Balanced B-50 B-complex Vitamins TabTabletOralPharmavite1995-12-312000-08-24Canada
Balanced B-50 B-complex Vitamins, Timed ReleTabletOralPharmavite1995-12-312006-07-05Canada
Balanced B-50 ComplexTabletOralLeiner Health ProductsNot applicableNot applicableCanada
Balanced B-complex Vit + Vit C&e TabTabletOralPharmavite1991-12-312006-07-05Canada
Balanced B100TabletOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Balanced B50 ComplexTabletOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Bev 29 TabTabletOralBeverly International Nutrition1987-12-311998-08-01Canada
Bev B-150TabletOralBeverly International Nutrition1986-12-311998-08-01Canada
BiferaRxTabletOralMeda Pharmaceuticals Ltd2012-10-31Not applicableUs
Bio-b12CapsuleOralThorne Research Inc.1997-09-092006-08-04Canada
Bio-fenCapsuleOralLisa & Gerry Freundl2001-10-102006-09-28Canada
BioFerr 90Tablet, film coatedOralBiocomp Pharma, Inc.2014-07-01Not applicableUs
BseltzerGranule, effervescentOralAbundance Marketing Ltd.2001-11-112007-07-23Canada
Bugs Bunny and Friends Multiple VitaminsTabletOralBayer Inc Consumer Care1996-12-312004-04-15Canada
Bugs Bunny Chew Multi Vit Plus IronTabletOralMiles Inc. Pharmaceutical Division1983-12-311996-09-09Canada
C-B ComplexTabletOralAvacare, Division Of Jeunique International Inc.1984-12-311996-09-09Canada
C-Nate DHACapsule, gelatin coatedOralCenturion Labs2013-01-01Not applicableUs
C.R.D.-forceCapsuleOralPrairie Naturals2001-09-192006-09-20Canada
Calcium Folic Acid Plus D ChewableWaferOralAcella Pharmaceuticals, LLC2010-03-23Not applicableUs
Carbassist TabletsTabletOralWyeth Ltd.1978-12-312006-07-24Canada
Cda-21 Vitamins With Non-medicinal Probiotic ComplexCapsuleOralRx Vitamins Inc.2006-08-012007-10-25Canada
Cedevita Plus Vitamin SupplementPowderOralPliva, Pharmaceutical, Chemical, Food And Cosmetic Industry, Inc.Not applicableNot applicableCanada
Cedevita Sugar-free Vitamin SupplementPowderOralPliva, Pharmaceutical, Chemical, Food And Cosmetic Industry, Inc.Not applicableNot applicableCanada
Central-vite 18 EssentialTabletOralVita Health Products Inc1998-04-242002-07-31Canada
Century CompleteTabletOralVita Health Products Inc1998-03-172002-07-31Canada
Chela Potassium PlusTabletOralNu Life Nutrition Ltd.1988-12-312000-03-03Canada
Chew.multiple Vits.with Extra C for ChildrenTabletOralRandle Pharmaceutical Inc.1996-09-191999-09-03Canada
Chewable Multiple Vit Plus Iron for ChildrenTabletOralRandle Pharmaceutical Inc.1996-09-191999-09-03Canada
Chewable Multiple Vitamins for ChildrenTabletOralRandle Pharmaceutical Inc.1996-09-191999-09-03Canada
Chewable Multiple Vitamins Plus Extra CTabletOralRandle Pharmaceutical Inc.1993-12-311999-09-03Canada
Chewable MultivitaminsTabletOralWn Pharmaceuticals Ltd.2002-05-312008-07-17Canada
Chewable Multivitamins Plus IronTabletOralWn Pharmaceuticals Ltd.2002-05-312007-08-07Canada
Children's Chewable Multi Vit W IronTabletOralShoppers Drug Mart Inc.1982-12-311997-08-15Canada
Children's Chewable Multi VitaminsTabletOralShoppers Drug Mart Inc.1982-12-311997-08-15Canada
Children's Chewable Multi Vitamins With Iron TabletsTabletOralVita Health Products Inc1998-05-202008-08-05Canada
Children's Chewable Multi-vitaminTabletOralWn Pharmaceuticals Ltd.2000-03-012007-08-07Canada
Children's Chewable Multi-vitamin Complete With MineralsTabletOralWn Pharmaceuticals Ltd.2000-03-012001-07-18Canada
Children's Chewable Multiple Vit.plus IronTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1997-10-102002-07-31Canada
Children's Chewable Multiple Vitamins - TabTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1997-10-102002-07-31Canada
Children's Chewable Multiple Vitamins (chewable Tablets)TabletOralPharmetics (2011) Inc.1999-08-162009-07-30Canada
Children's Chewable Multiple Vitamins With Extra Vitamin C (chewable Tablets)TabletOralPharmetics (2011) Inc.1999-08-162009-07-30Canada
Children's Chewable Multiple Vitamins With Iron Tablets (chewable Tablets)TabletOralPharmetics (2011) Inc.1999-08-162009-07-30Canada
Children's Vitamins ChewableTabletOralVita Health Products Inc1990-12-312002-07-31Canada
Children's Vitamins W Iron ChewableTabletOralVita Health Products Inc1990-12-312002-07-31Canada
Childrens Chew Multi Vitamin TabTabletOralNutristar Health Products (1987) Inc.1983-12-311996-09-09Canada
Childrens Chewable Multiple VitaminsTabletOralKsl Pharmaceuticals1994-12-311999-08-12Canada
Childrens Chewable Multiple Vitamins Plus FeTabletOralKsl Pharmaceuticals1994-12-312000-08-29Canada
Childrens Chewable Multiple Vitamins TabTabletOralPharmavite1987-12-312000-08-24Canada
Childrens Chewable VitaminsTabletOralD.C. Labs Limited1974-12-312003-07-11Canada
ChromagenCapsuleOralAvion Pharmaceuticals, Llc2017-01-23Not applicableUs
CiferexCapsuleOralAdler Stern Pharmaceuticals, Llc2014-11-112017-09-13Us
CifrazolCapsuleOralSterling Knight Pharmaceuticals, Llc2017-01-10Not applicableUs
CitraNatal B-CalmKitMission Pharmacal2010-02-10Not applicableUs
CitraNatal BloomTablet, film coatedOralMission Pharmacal2017-08-01Not applicableUs
CitraNatal DHATabletOralMission Pharmacal2007-11-20Not applicableUs
CitraNatal Harmony 3.0Capsule, gelatin coatedOralMission Pharmacal2014-03-21Not applicableUs
CitraNatal RxTabletOralMission Pharmacal2014-08-11Not applicableUs
Co-VeratrolCapsuleOralHome Aide Diganostics, Inc.2015-08-01Not applicableUs
Complete Mega BTabletOralGahler Enterprises Ltd.1985-12-312001-07-26Canada
Complete Multivitamins and Minerals for ChildrenTabletOralQuest Vitamins A Div Of Purity Life Health Products2001-01-312004-06-29Canada
Complete Multivitamins and Minerals Tablets Timed ReleaseTablet, extended releaseOralPharmetics (2011) Inc.1999-07-262009-07-30Canada
Complex-75CapsuleOralFrega Inc.1990-12-311999-08-06Canada
Complexe B 75mgTabletOralPharmalab Inc.1994-12-312001-07-30Canada
Complexe B Compose 75TabletOralLes Laboratoires Bio SantÉ Inc.1983-12-311996-09-10Canada
Complexe B-75TabletOralFrega Inc.1998-06-292008-02-13Canada
Concept DHACapsule, liquid filledOralUs Pharmaceutical Corporation2009-06-24Not applicableUs
Concept OBCapsuleOralUs Pharmaceutical Corporation2009-01-01Not applicableUs
Cool BCapsuleOralSisu Inc.2002-01-092008-07-25Canada
Daily Energy Brand B-complexCapsuleOralEnzymatic Therapy, Inc.2004-01-012008-07-25Canada
Derma-forceCapsuleOralPrairie Naturals1997-04-012006-09-20Canada
DermacinRx FoliPlus DCapsule, liquid filledOralPure Tek Corporation2016-07-15Not applicableUs
DermacinRx PureFolixTabletOralPure Tek Corporation2015-11-03Not applicableUs
DermaNICTabletOralAllegis Pharmaceuticals, LLC2014-02-032017-08-02Us
Dia-viteTabletOralR & D Laboratories Inc.1997-08-132003-07-16Canada
DiaplexTabletOralNephro Tech, Inc.2002-07-102004-07-23Canada
DivistaCapsuleOralUs Pharmaceutical Corporation2010-07-10Not applicableUs
DuracholCapsuleOralSterling Knight Pharmaceuticals, Llc2014-11-16Not applicableUs
E.S.T. ComplexTabletOralAbundance Marketing Ltd.2000-12-062004-06-30Canada
Efferlife Multivitamins and MineralsTablet, effervescentOralNaturale Science Inc.2001-10-012006-10-10Canada
EnBrace HRCapsule, delayed release pelletsOralJaymac Pharmaceuticals, Llc2015-04-08Not applicableUs
Energy 80 Prolonged Release TabTablet, extended releaseOralSportscience Labs Inc.1981-12-312002-06-20Canada
EnLyteCapsule, delayed release pelletsOralJaymac Pharmaceuticals Llc2011-10-01Not applicableUs
EscaviteTablet, chewableOralGm Pharmaceuticals2012-02-01Not applicableUs
Essential B TabletsTabletOralGeneral Nutrition Canada Inc.1997-04-182006-08-03Canada
Extra P.N. Vitamin-mineral Drink MixPowderOralChanges InternationalNot applicableNot applicableCanada
Extra-Virt Plus DHACapsule, gelatin coatedOralVirtus Pharmaceuticals2012-12-28Not applicableUs
Ez-flexTabletOralMetagenics, Inc.1997-06-302007-09-07Canada
FaBB TabletsTabletOralMidlothian Laboratories2009-01-01Not applicableUs
FE C Tab PlusTabletOralBoca Pharmacal, Inc.2011-03-312015-12-29Us
Fem - ControlTabletOralMetagenics, Inc.1998-01-312005-08-19Canada
Feminex 300 TabTabletOralSantÉ Naturelle (Ag) LtÉe1986-12-311997-09-09Canada
Feminique W Iron and Calcium TabTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1992-12-311998-08-13Canada
Femitab TabTabletOralLe Groupe Prodeal Ltee1988-12-312009-08-05Canada
FeRivaCapsuleOralAvion Pharmaceuticals, Llc2012-12-30Not applicableUs
FeRiva FACapsule, gelatin coatedOralAvion Pharmaceuticals, Llc2014-12-18Not applicableUs
FeRivaFACapsule, gelatin coatedOralAvion Pharmaceuticals, Llc2014-01-02Not applicableUs
Ferralet 90Tablet, film coatedOralMission Pharmacal2010-02-042017-08-24Us
Fib-C MeltsTabletOralApm Products Pty Ltd.2003-08-152004-09-10Canada
Flinstones Multiple Plus IronTabletOralMiles Inc. Pharmaceutical Division1971-12-311996-09-09Canada
Flintstones Multiple VitaminsTabletOralBayer Inc Consumer Care1995-12-312004-06-28Canada
Flintstones Multiple Vitamins Plus IronTabletOralBayer Inc Consumer Care1995-12-312004-06-28Canada
Flintstones Multiple Vitamins TabTabletOralMiles Inc. Pharmaceutical Division1970-12-311996-09-09Canada
Flintstones W Extra C TabTabletOralMiles Inc. Pharmaceutical Division1981-12-311996-09-09Canada
Floradix Formula LiqLiquidOralFlora Manufacturing And Distributing Ltd.1979-12-312002-06-05Canada
FlorivaTablet, chewableOralBon Geo Pharmaceuticals, Inc.2015-09-10Not applicableUs
FolbicTabletOralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-02-19Not applicableUs51991 0384 90 nlmimage10 9c07ce0e
Folcal DHACapsule, gelatin coatedOralMidlothian Laboratories2010-12-01Not applicableUs
FolcapsTabletOralMidlothian Laboratories2009-01-01Not applicableUs
Folcaps Care OneCapsule, gelatin coatedOralMidlothian Laboratories2009-05-01Not applicableUs
Folcaps Omega-3Capsule, gelatin coatedOralMidlothian Laboratories2011-01-03Not applicableUs
Folet OneCapsule, liquid filledOralPronova Corporation2014-06-01Not applicableUs
Folic Acid & Vitamin CTabletOralHolista Health (Canada) Inc.2003-02-052006-08-02Canada
Folic Acid 1mg With C 20mgTabletOralGahler Enterprises Ltd.1986-12-312006-07-26Canada
Folic Acid 1mg With Vitamin CTabletOralWn Pharmaceuticals Ltd.1998-09-142007-08-07Canada
Folic Acid PlusTabletOralVita Health Products Inc2000-04-012002-07-31Canada
Folic Acid With Vitamin B12 and Vitamin CCapsuleOralFlora Manufacturing And Distributing Ltd.2003-12-312009-08-05Canada
Folic Acid-b12 TabTabletOralStandard Process Inc.Not applicableNot applicableCanada
Folivane-PRx DHACapsuleOralTrigen Laboratories, Inc.2010-01-01Not applicableUs
FolixapureTabletOralShoreline Pharmaceuticals, Inc.2016-05-13Not applicableUs
Foltabs 800TabletOralMayne Pharma2009-01-012019-06-30Us
Foltabs PrenatalTabletOralMidlothian Laboratories2009-01-01Not applicableUs
FoltrateTablet, film coatedOralPoly Pharmaceuticals2010-08-26Not applicableUs
For Kids Only Chewable Multivit. Plus IronTabletOralKsl Pharmaceuticals1996-12-312002-07-31Canada
For Kids Only Chewable Multivitamins - TabTabletOralKsl Pharmaceuticals1996-12-312002-07-31Canada
Formula Ch. Les.TabletOralAbundance Marketing Ltd.2002-06-032004-06-30Canada
Formula CnCapsuleOralBalance Plus, Inc.2000-02-092004-08-17Canada
Formula D.S.TabletOralGolden Pride InternationalNot applicableNot applicableCanada
Formula InfCapsuleOralBalance Plus, Inc.2000-02-092004-08-17Canada
Formula IntCapsuleOralBalance Plus, Inc.2000-02-092004-08-17Canada
Formula L.G.I.TabletOralMetagenics, Inc.1997-06-302002-10-07Canada
Formula O-care Vitamin and Mineral SupplementTabletOralFor Mor International Inc.2000-03-252002-06-25Canada
Formula U - TabTabletOralMetagenics, Inc.1997-03-052002-10-07Canada
Fortamines 10 CapsulesCapsuleOralRougier Pharma Division Of Ratiopharm Inc1974-12-311999-09-27Canada
Fortamines-10 ComprimesTabletOralRougier Pharma Division Of Ratiopharm Inc1979-12-312003-09-22Canada
G.A.S. ComplexTabletOralAbundance Marketing Ltd.2000-12-062004-06-30Canada
Gestamine ComprimesTabletOralLab Nadeau LtÉe, Division Of Technilab Inc.1957-12-311999-09-28Canada
Gesticare DHAKitJazz Pharmaceuticals Commercial Corp.2008-10-01Not applicableUs
Globucel - MethodeCapsuleOralLes Laboratoires Swisse Inc.1997-08-302009-08-05Canada
Harvest Of Values All B Complex TabTabletOralHillestad Pharmaceuticals Usa1997-09-242009-09-22Canada
healthy mamaBE WELL ROUNDED BE WELL ROUNDEDTablet, film coatedOralMATERNAL SCIENCE, LLC2013-07-09Not applicableUs
Hematogen FACapsuleOralNnodum Pharmaceuticals2005-01-01Not applicableUs
Hematogen ForteCapsule, gelatin coatedOralNnodum Pharmaceuticals2007-05-10Not applicableUs
HemeNatal OBTabletOralWh Nutritionals, Llc2012-03-08Not applicableUs
HemetabTabletOralWh Nutritionals, Llc2012-05-01Not applicableUs
Hi Potency B Complex W Chelated MineralsTabletOralKlaire Labs Inc.1984-12-312004-01-19Canada
Hi Potency B52 B Complex TabTabletOralCountry Health Laboratories Ltd.1982-12-312001-07-27Canada
Hi Potency Balanced B-100 Complex - TabTabletOralLeiner Health ProductsNot applicableNot applicableCanada
Hi Potency Stress B Tension With CTabletOralLee Adams Laboratories1982-12-312010-08-05Canada
Hill.viteTabletOralHillestad Pharmaceuticals Usa2001-11-142009-09-22Canada
Homosistrol CapsulesCapsuleOralMacromed Pharmicia Inc.Not applicableNot applicableCanada
Hypo Vites TabTabletOralPharmetics (2011) Inc.1977-12-312006-07-27Canada
Iferex 150 ForteCapsuleOralNnodum Pharmaceuticals2007-10-28Not applicableUs
Inatal AdvanceTablet, coatedOralNnodum Pharmaceuticals2005-06-10Not applicableUs
INATAL UltraTablet, coatedOralNnodum Pharmaceuticals2005-06-20Not applicableUs
Infuvite Adult Multiple VitaminsInjection, solutionIntravenousSandoz2005-05-18Not applicableUs
Integra FCapsuleOralUs Pharmaceutical Corporation2009-04-27Not applicableUs
Integra PlusCapsuleOralUs Pharmaceutical Corporation2009-04-27Not applicableUs
Iron 25mg With Vit B-cmplx, Vit C, Cu & MoCapsuleOralQuest Vitamins A Div Of Purity Life Health Products1996-07-232002-07-29Canada
Iron Plus Manganese, B12, Folic Acid & CTabletOralNatural Factors Nutritional Products Ltd.1988-12-312005-08-15Canada
Iron Plus TabTabletOralSwiss Herbal Remedies Ltd.1973-12-312008-08-15Canada
Iron Polysaccharides Folic Acid DHATablet, film coatedOralVirtus Pharmaceuticals2013-12-202017-08-11Us
Iron Vitamins B6,b12,c,folic Acid TabTabletOralLaboratoire Lalco Inc.1989-12-311997-07-31Canada
Iron With Vitamins TabTabletOralEnrich International1994-12-312001-09-28Canada
Isotonix Advanced B-complex Vitamins With Potassium and MagnesiumPowderOralMarket America2004-01-272009-07-20Canada
Isotonix Vitamin B-folic Acid-mineral SupplePowderOralMarket America1996-12-312004-07-12Canada
Kanga-kid Multi-vitamin & MineralTablet, effervescentOralLacombe Drugs (1992) LtdNot applicableNot applicableCanada
Kanga-V Multivitamins & MineralsTablet, effervescentOralLacombe Drugs (1992) LtdNot applicableNot applicableCanada
Kid's Choice Children's Chewable Vitamins - TabTabletOralVita Health Products Inc1998-04-162002-07-31Canada
Kids Stuff TabletsTabletOralVita Health Products Inc1998-04-202002-07-31Canada
Kids Stuff With Iron TabletsTabletOralVita Health Products Inc1998-04-202002-07-31Canada
Kimchi Vitamin chewable multivitaminTablet, chewableOralTobico2010-03-18Not applicableUs
KindervitesSolution / dropsOralHerbalife International Of America1984-12-312002-09-17Canada
L.I.P. ComplexTabletOralAbundance Marketing Ltd.2000-12-062004-06-30Canada
Lipo-B-C TabTabletOralMetagenics, Inc.1989-12-311996-10-02Canada
Liqui B ComplexLiquidOralTwin Laboratories Inc.1995-12-311999-11-10Canada
Liqui B Complex PlusLiquidOralTwin Laboratories Inc.1995-12-311999-11-10Canada
Liqui VitaLiquidOralTwin Laboratories Inc.1995-12-311999-11-10Canada
Liquid B Complex 50LiquidOralJamieson Laboratories Ltd1985-12-311997-08-13Canada
Low Potency B Complex TabTabletOralFlora Manufacturing And Distributing Ltd.1983-12-311999-10-18Canada
M.V.I. 12LiquidIntravenousAventis Pharma Ltd.1992-12-312002-07-29Canada
M.V.I. PaediatricLiquidIntravenousAventis Pharma Ltd.1988-12-312002-07-29Canada
M.V.I. PediatricInjection, powder, lyophilized, for solutionIntravenousHospira Worldwide, Inc.1983-04-06Not applicableUs
MacuzinCapsuleOralSterling Knight Pharmaceuticals, Llc2015-04-302017-09-13Us
Mag-A-folic TabTabletOralMetagenics, Inc.1989-12-311996-10-02Canada
MagneBind 400 RxTablet, film coatedOralNephro Tech, Inc.1999-10-18Not applicableUs
MaxFeTabletOralPronova Corporation2014-06-01Not applicableUs
Maxi 10 TabTabletOralDesbergers LtÉe, Division Of Technilab Inc.1979-12-311999-09-17Canada
Mega 13 Multivitamin FormulaCapsuleOralVita Health Products Inc1988-12-311998-07-22Canada
MethaverCapsuleOralSterling Knight Pharmaceuticals, Llc2015-11-24Not applicableUs
Mini-B TabTabletOralTwin Laboratories Inc.1995-12-311999-11-10Canada
Mnps Formula SupplementTabletOralGarden State NutritionalsNot applicableNot applicableCanada
Mr. Tumee Multi-vitaminTablet, chewableOralVitamec Usa2003-04-152006-09-29Canada
Multi 12 InjectionLiquidIntravenousSandoz Canada Incorporated1994-12-31Not applicableCanada
Multi BTabletOralSeroyal International Inc.1988-12-312009-07-06Canada
Multi Enfants TabTabletOralVitalab1992-12-311997-07-22Canada
Multi Vitamin - MineralTabletOralEnrich International1999-11-112001-09-28Canada
Multi Vitamin & MineralsTabletOralWn Pharmaceuticals Ltd.2002-01-042008-07-17Canada
Multi Vitamin Plus IronTabletOralWn Pharmaceuticals Ltd.2002-03-132009-09-28Canada
Multi Vitamin with FluorideTablet, chewableOralQualitest2009-10-092016-10-13Us
Multi Vitamin-mineral FormulaTabletOralVita Health Products Inc1997-04-031998-01-16Canada
Multi Vitamines - LiqLiquidOralLand Art Inc.1995-12-312008-06-26Canada
Multi Vitamins & MineralsTabletOralWn Pharmaceuticals Ltd.2000-01-122001-04-12Canada
Multi-11SolutionIntravenousSandoz Canada Incorporated2002-01-28Not applicableCanada
Multi-12 PediatricLiquidIntravenousSabex Inc1998-04-092009-11-26Canada
Multi-12/k1 PediatricLiquidIntravenousSandoz Canada Incorporated2000-11-07Not applicableCanada
Multi-VitaminTablet, chewableOralBoca Pharmacal, Inc.2011-12-282016-10-28Us
Multi-vitamin Dietary SupplementTabletOralGarden State Nutritionals1998-09-222000-06-07Canada
Multi-Vitamin With FluorideTablet, chewableOralGolden State Medical Supply2010-12-17Not applicableUs
Multi-vitaminsTabletOralWn Pharmaceuticals Ltd.1999-12-222008-07-17Canada
Multi-vitamins With MineralsTabletOralWn Pharmaceuticals Ltd.2001-04-122009-09-28Canada
Multiple VitaminsTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1987-12-312002-07-31Canada
Multiple Vitamins & Minerals TabletsTabletOralPharmetics (2011) Inc.2002-12-182006-07-27Canada
Multiple Vitamins Plus Iron for WomenTabletOralPharmetics (2011) Inc.1999-08-162006-07-27Canada
Multiple Vitamins Plus Iron TabTabletOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Multiple Vitamins TabTabletOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Multiple Vitamins With IronTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1987-12-312002-07-31Canada
MultivitaminTabletOralLaboratoires Confab IncNot applicableNot applicableCanada
Multivitamin with fluorideTablet, chewableOralA S Medication Solutions2011-12-202017-06-20Us
Multivitamines Et Mineraux Junior RegulierTabletOralLaboratoire Riva Inc1996-10-082008-07-30Canada
Multivitamines Et Mineraux Reguliers / Regular Multivitamins and MineralsTabletOralVita Health Products Inc1998-10-062004-07-26Canada
Multivitamines Plus Fer Pour Enfants (chewable Tablets)TabletOralLaboratoire Lalco Inc.1998-07-032002-09-05Canada
Multivitamines Pour Enfants (chewable Tablets)TabletOralLaboratoire Lalco Inc.1998-07-032002-09-05Canada
Multivitamins and Minerals - CompleteTabletOralVita Health Products Inc2000-02-012006-07-31Canada
Multivitamins and Multiminerals Formula Regular TabletTabletOralPharmetics (2011) Inc.2001-11-222009-07-30Canada
Multivitamins for ChildrenTabletOralQuest Vitamins A Div Of Purity Life Health Products2001-01-312004-06-29Canada
MvcTablet, chewableOralSancilio & Company Inc.2009-12-20Not applicableUs
MVC-FluorideTablet, chewableOralSancilio & Company Inc.2011-12-07Not applicableUs
Myferon 150 ForteCapsuleOralMartin Ekwealor Pharmaceuticals, Inc.1996-12-01Not applicableUs
Myhephron Dialysis and Stress SupplementCapsuleOralMartin Ekwealor Pharmaceu2016-08-01Not applicableUs
Mynephrocaps Dialysis/stress Vitamin SupplementCapsuleOralMartin Ekwealor Pharmaceuticals, Inc.2013-12-16Not applicableUs
N.E.U. ComplexTabletOralAbundance Marketing Ltd.2000-12-042004-06-30Canada
N.U.T. ComplexTabletOralAbundance Marketing Ltd.2000-12-062004-06-30Canada
Nata KompleteTabletOralWh Nutritionals, Llc2011-06-252016-12-06Us
NataFortTabletOralMission Pharmacal2011-08-25Not applicableUs
NataviteTabletOralSchein Pharmaceutical Canada Inc.1997-07-292004-07-26Canada
Natelle OneCapsule, gelatin coatedOralMeda Pharmaceuticals Ltd2015-02-01Not applicableUs
NephrocapsCapsule, liquid filledOralCardinal Health2010-01-14Not applicableUs
Nestabs ONECapsule, gelatin coatedOralWomens Choice Pharmaceuticals, Llc2017-07-20Not applicableUs
Neutral C + Coenzyme Q10 Plus Vitamins & MineralsCapsuleOralNew Vision Nutritionals Company1998-06-072002-11-20Canada
Nexa PlusCapsuleOralUpsher Smith Laboratories2012-08-01Not applicableUs
Nexa Select Rx Prenatal Vitamin with Plant-Based DHACapsuleOralUpsher Smith Laboratories2012-12-17Not applicableUs
Niaacinamide Azelaic AC TURMER FA B6 Zinc Ox CopperTablet, coatedOralVirtus Pharmaceuticals2014-05-092017-08-03Us
NicomideTabletOralAvion Pharmaceuticals, Llc2012-06-15Not applicableUs
NiferexTabletOralAvion Pharmaceuticals, Llc2017-01-23Not applicableUs
Nioxin Recharging ComplexCapsuleOralNioxin Research Laboratories, Inc.2002-06-192008-06-20Canada
Niron KompleteTabletOralWh Nutritionals, Llc2011-06-252016-12-06Us
NuFeraTabletOralCarwin Associates, Inc2015-12-16Not applicableUs
Nutrifer Plus TabletsTabletOralWyeth Ayerst Canada Inc.1994-12-311999-09-23Canada
Nutrilite Double XTabletOralNutrilite, A Division Of Access Business Group, Llc2002-12-152008-06-24Canada
Nutrol-B-complexTabletOralRolmex International Inc.1999-06-282008-07-09Canada
O-Cal FA multivitaminTabletOralPharmics, Inc.1970-01-15Not applicableUs
O-Cal Prenatal VitaminTabletOralPharmics, Inc.2002-01-23Not applicableUs
OcuvelCapsuleOralAdler Stern Pharmaceuticals, Llc2014-11-05Not applicableUs
OnccorTabletOralSimone Protective Pharmaceuticals, Inc.Not applicableNot applicableCanada
One A Day Advance AdultsTabletOralBayer Inc Consumer Care2002-09-122007-08-02Canada
One A Day Advance Adults 50+TabletOralBayer Inc Consumer Care2002-09-122007-08-02Canada
One A Day Advance FemTabletOralBayer Inc Consumer Care1999-03-012001-02-22Canada
One A Day TabTabletOralCountry Health Laboratories Ltd.1982-12-312001-07-27Canada
Orange Flavored Crystal Chews TabTabletOralJeunique International Inc.1998-02-172006-07-20Canada
Orifer FTabletOralSanofi Aventis1995-12-312007-11-22Canada
Ortho DCapsuleOralSolubiomix2015-08-08Not applicableUs
Orti BCapsuleOralSeroyal International Inc.1983-12-312008-10-09Canada
P.N.P. Vitamin DrinkLiquidOralChanges InternationalNot applicableNot applicableCanada
P.R.O. ComplexTabletOralAbundance Marketing Ltd.2000-12-062004-06-30Canada
Pediatric Infuvite Multiple VitaminsInjection, solutionIntravenousSandoz2001-02-21Not applicableUs
Pediatric Infuvite Multiple Vitamins for InfusionInjection, solutionIntravenousSandoz2001-02-21Not applicableUs
PhytopureCapsuleOralLaboratoire Lalco Inc.1993-12-312001-10-15Canada
PM CapsCapsuleOralNew Vision Nutritionals Company1998-10-012002-11-20Canada
PNV Ferrous Fumarate Docusate Folic AcidTabletOralVirtus Pharmaceuticals2014-04-22Not applicableUs
PNV Prenatal Plus MultivitaminTabletOralClinical Solutions Wholsesale2013-04-012017-07-03Us
PNV Prenatal VitaminTablet, chewableOralSancilio & Company Inc.2011-12-20Not applicableUs
PNV Prenatal Vitamin Plus Vitamin ATabletOralSancilio & Company Inc.2012-12-07Not applicableUs
Pnv-dhaCapsule, gelatin coatedOralAcella Pharmaceuticals, LLC2009-11-02Not applicableUs
PNV-FirstTablet, coatedOralAcella Pharmaceuticals, LLC2013-05-17Not applicableUs
PNV-SelectTablet, film coatedOralAcella Pharmaceuticals, LLC2009-11-02Not applicableUs
Polymine Avec Zinc Et CuivreTabletOralLes Laboratoires Vachon Inc.1985-12-312007-07-12Canada
Potassium W Folic Acid TabTabletOralQuest Vitamins A Div Of Purity Life Health Products1978-12-312008-07-07Canada
Prefera OB plus DHATabletOralAlaven Pharmaceutical2009-04-01Not applicableUs
PreferaOBTablet, coatedOralMeda Pharmaceuticals Ltd2015-04-28Not applicableUs
PreferaOB ONECapsule, liquid filledOralMeda Pharmaceuticals Ltd2015-04-28Not applicableUs
PreferaOB plus DHATabletOralAlaven Pharmaceutical2010-11-15Not applicableUs
PregvitTabletOralDuchesnay Inc.2003-08-252016-07-05Canada
Pregvit Folic 4TabletOralDuchesnay Inc.Not applicableNot applicableCanada
Pregvit Folic 5TabletOralDuchesnay Inc.2006-03-172016-07-05Canada
PrenaissanceCapsule, liquid filledOralAcella Pharmaceuticals, LLC2011-05-192017-09-08Us
Prenaissance PlusCapsule, liquid filledOralAcella Pharmaceuticals, LLC2011-09-12Not applicableUs
PreNatal 19Tablet, coatedOralNationwide Laboratories2013-06-01Not applicableUs
Prenatal Mega AntioxidantTabletOralUsana Health Services, Inc.2012-04-11Not applicableUs
Prenatal PlusTablet, film coatedOralBlenheim Pharmacal, Inc.2010-12-09Not applicableUs65162 0668 50 nlmimage10 120e0910
Prenatal Plus IronTablet, film coatedOralMajor2011-06-07Not applicableUs
PreNatal Vitamins PlusTabletOralbryant ranch prepack2011-04-15Not applicableUs
Prenatal Vitamins Plus Low IronTabletOralPatrin Pharma2013-04-01Not applicableUs39328 0106 10 nlmimage10 df476fdb
Prenatal, DHAKitPure Tek Corporation2017-08-10Not applicableUs
Prenate AMTablet, coatedOralAvion Pharmaceuticals, Llc2013-06-15Not applicableUs
Prenate EliteTablet, coatedOralAvion Pharmaceuticals, Llc2012-08-06Not applicableUs
PRENATE EnhanceCapsule, gelatin coatedOralAvion Pharmaceuticals, Llc2013-09-17Not applicableUs
Prenate EssentialCapsule, gelatin coatedOralAvion Pharmaceuticals, Llc2014-07-18Not applicableUs
Prenate PixieTablet, film coatedOralAvion Pharmaceuticals, Llc2014-08-14Not applicableUs
PRENATE RestoreCapsule, gelatin coatedOralAvion Pharmaceuticals, Llc2013-09-17Not applicableUs
Prenate StarTablet, coatedOralAvion Pharmaceuticals, Llc2014-06-05Not applicableUs
Prenavite ForteTabletOralAllen & Hanburys A Glaxo Canada Ltd. Co.1986-12-311996-09-10Canada
Prenavite Forte TabletsTabletOralRoberts Pharmaceutical1995-12-311999-08-11Canada
Prenavite TabletsTabletOralRoberts Pharmaceutical1995-12-311999-08-11Canada
PreNexaCapsule, gelatin coatedOralUpsher Smith Laboratories2010-05-25Not applicableUs
PrePLUSTabletOralVirtus Pharmaceuticals2014-04-04Not applicableUs
PreQue 10TabletOralActavis Pharma Company2011-11-01Not applicableUs
PreTABTabletOralVirtus Pharmaceuticals2014-04-092017-08-08Us
PureVit DualFe PlusCapsuleOralPure Tek Corporation2011-06-01Not applicableUs
Q.T. Vitamin and Mineral Drink MixPowderOralGarden State NutritionalsNot applicableNot applicableCanada
Reaphirm Plant Source DHACapsule, gelatin coatedOralEverett Laboratories, Inc.2011-12-05Not applicableUs
ReebokLiquidOralClearly Canadian Beverage Corporation2003-05-152009-08-06Canada
Reliv So Sense Daily Vitamin SupplementPowder, for solutionOralReliv International Inc.2000-03-242007-07-10Canada
Reno CapsCapsuleOralNnodum Pharmaceuticals2008-11-30Not applicableUs63044 0622 01 nlmimage10 7d3cbea5
ReplaviteTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1999-10-202002-07-31Canada
RevestaCapsuleOralSterling Knight Pharmaceuticals, Llc2016-10-13Not applicableUs
Revit Plus CapCapsuleOralIcn Pharmaceuticals1972-12-311998-08-13Canada
Right Choice A.M. Multi Formula - CapletTabletOralBody Wise International LlcNot applicableNot applicableCanada
Se-Care ChewableTablet, chewableOralSeton Pharmaceuticals2009-05-012016-10-13Us
Se-Natal 19TabletOralSeton Pharmaceuticals2009-07-01Not applicableUs
Se-Natal 19 ChewableTablet, chewableOralSeton Pharmaceuticals2009-07-01Not applicableUs
Se-Natal OneTabletOralSeton Pharmaceuticals2009-04-162016-10-13Us
Se-Tan DHACapsule, gelatin coatedOralSeton Pharmaceuticals2009-10-012016-04-30Us
Se-Tan PLUSCapsule, gelatin coatedOralSeton Pharmaceuticals2009-10-01Not applicableUs
Sodium polysulthionate and folic acidCapsuleOralSolubiomix2016-08-24Not applicableUs
Somavit Brand Vitamins and Minerals ComplexTabletOralSoma Health Products2000-01-152005-08-26Canada
Sopalamine/3b Plus CTabletOralTechnilab Pharma Inc.1987-12-312001-09-05Canada
Spd TabTabletOralSeroyal International Inc.1988-12-311996-09-10Canada
Spectrum 2 CapCapsuleOralNf Formulas Inc.1988-12-312008-06-26Canada
Stress B & C CapletTabletOralHealth Wise Nutrition Inc.1995-12-311998-08-25Canada
Stress B Capsules With Vitamin CCapsuleOralRheingold Food International Ltd.1987-12-312007-07-26Canada
Stress B Complex With C, E & IronTabletOralPharmavite1999-10-312005-07-15Canada
Stress B With 1000 Mg Vitamin CTabletOralHolista Health (Canada) Inc.2002-11-132008-07-17Canada
Stress B&c TabTabletOralBioforce Canada Inc.1985-12-311997-04-04Canada
Stress Complex 600 Avec Vit E Cuivre ZincTabletOralFrega Inc.1995-12-312008-02-13Canada
Stress Ctr SrtTablet, extended releaseOralBioenergy Inc.1979-12-311998-06-03Canada
Stress FormulaTabletOralVita Health Products Inc1998-05-202005-07-20Canada
Stress Formula + IronTabletOralVita Health Products Inc1998-05-202006-07-31Canada
Stress Formula B-comp + 500mg Vit C TabTabletOralQuest Vitamins A Div Of Purity Life Health Products1987-12-312002-07-29Canada
Stress Formula Multi-B Comp + 500mg Vit C CapCapsuleOralQuest Vitamins A Div Of Purity Life Health Products1987-12-312001-07-06Canada
Stress Formula Multivitamin Tablets USPTabletOralLeiner Health ProductsNot applicableNot applicableCanada
Stress Formula TabTabletOralNatures Sunshine Products, Inc.1986-12-312009-09-09Canada
Stress Formula Vit B With C ComplexTabletOralWatkins Incorporated1985-12-312000-01-15Canada
Stress Forte Plus Lipotropic FactorsTabletOralDouglas Laboratories1995-12-312009-09-29Canada
Stress Vitamin B With C Complex TabletsTabletOralPurity Life Health Products A Division Of Sunopta Inc.2002-06-012007-07-26Canada
StressmatesTabletOralTwin Laboratories Inc.1995-12-311999-11-10Canada
Strovite Forte CapletTablet, coatedOralEverett Laboratories, Inc.1996-10-01Not applicableUs
Strovite One CapletsTabletOralEverett Laboratories, Inc.2001-05-04Not applicableUs
Sun-rype VitaburstLiquidOralSun Rype Products Ltd.2004-08-102008-03-13Canada
Super B Compound W 500mg Vit CTabletOralGahler Enterprises Ltd.1986-12-312000-08-01Canada
Super B12 + Folic AcidTabletOralSeroyal International Inc.1998-12-312009-07-06Canada
Super Charged EnergyPowderOralSimone Protective Pharmaceuticals, Inc.Not applicableNot applicableCanada
Super Daily No 2TabletOralW.R. Enterprises Inc.1990-12-312003-07-30Canada
Super PantoplexTabletOralNu Life Nutrition Ltd.1987-12-312000-03-03Canada
Super Stress CapsulesCapsuleOralRheingold Food International Ltd.1987-12-311997-08-22Canada
Super Stress Mega B Plus 1000mg Vit C TabTabletOralQuest Vitamins A Div Of Purity Life Health Products1987-12-312001-07-06Canada
Supplement De Multivitamines Infusion Arome Fruits RougesKitOralYves Rocher Inc.1999-10-182000-08-08Canada
Supplement De Vitamines Et MinerauxLiquidOralLand Art Inc.1998-01-201999-08-02Canada
Supravite Stress Avec Vit ETabletOralPharmalab Inc.1985-12-311997-08-08Canada
Supravite Stress Avec Vit E Cuivre Et ZincTabletOralPharmalab Inc.1985-12-311997-08-08Canada
Supravite Stress Avec Vit E Et FerTabletOralPharmalab Inc.1985-12-311997-08-08Canada
Surbex-500 With IronTabletOralAbbott1986-12-312008-06-06Canada
SveetsLozengeOralSensible Delights Specialty Foods1998-09-162000-09-19Canada
T.R.I. B-plex SrcCapsule, extended releaseOralAnabolic Laboratories Inc.1979-12-312004-03-15Canada
Tandem - FCapsuleOralUs Pharmaceutical Corporation2006-06-17Not applicableUs
Tandem DHACapsuleOralUs Pharmaceutical Corporation2007-01-17Not applicableUs
Tandem OBCapsuleOralUs Pharmaceutical Corporation2006-06-17Not applicableUs
Tandem PlusCapsuleOralUs Pharmaceutical Corporation2006-06-17Not applicableUs
Tar-endCapsuleOralNatures Sunshine Products, Inc.1999-05-252006-07-10Canada
Tianshi Vital Powder IPowderOralTianjin Tianshi Group Co., Ltd.Not applicableNot applicableCanada
Tianshi Vital Powder IIIPowderOralTianjin Tianshi Group Co., Ltd.Not applicableNot applicableCanada
Time Release B 100 Compound - TabletTabletOralHealth Wise Nutrition Inc.1996-10-222002-07-18Canada
Timed Release B Complex 100 SrtTablet, extended releaseOralJamieson Laboratories Ltd1994-12-311997-08-13Canada
Timed Release B-complex 100Tablet, extended releaseOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Timed Release B-complex 50Tablet, extended releaseOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Tl-hem 150Tablet, film coatedOralTrigen Laboratories, Inc.2011-01-01Not applicableUs
TozalCapsule, gelatin coatedOralFocus Laboratories, Inc.2013-06-012016-10-13Us
TriAdvanceTabletOralTrigen Laboratories, Inc.2010-09-102017-09-16Us
Tricare PrenatalTablet, coatedOralMedecor Pharma, Llc2002-11-11Not applicableUs
TriconCapsuleOralNnodum Pharmaceuticals2005-05-20Not applicableUs
Trinatal GTTabletOralTrigen Laboratories, Inc.2011-07-052017-09-13Us
Triveen-PRx RNFCapsuleOralTrigen Laboratories, Inc.2010-05-152017-09-16Us
UltimateCare ONE NFCapsuleOralTrigen Laboratories, Inc.2009-12-042017-09-16Us
Ultra HrTabletOralNatural Organics Inc.Not applicableNot applicableCanada
Usana Megavitamin Tablets - TabTabletOralUsana Health Sciences, Inc.1996-12-302000-09-11Canada
VemaVite-PRx 2 with Fish-Based DHACapsuleOralTrigen Laboratories, Inc.2011-10-05Not applicableUs
Vigo Multivitamins Drops/lozengeLozengeOralAshbury Research CorporationNot applicableNot applicableCanada
Vimeral TabTabletOralIcn Pharmaceuticals1979-12-312005-04-26Canada
Virt-CapsCapsule, gelatin coatedOralVirtus Pharmaceuticals2014-04-012017-08-11Us
Virt-PN PlusCapsule, gelatin coatedOralVirtus Pharmaceuticals2013-03-012017-08-08Us
Virt-ViteTabletOralVirtus Pharmaceuticals2014-01-042017-09-09Us
Virt-Vite PlusTabletOralVirtus Pharmaceuticals2014-01-142017-08-11Us
Vit B Complex CtrTablet, extended releaseOralBioenergy Inc.1979-12-311998-06-03Canada
Vit-HA Multi Vitamin and Zinc SupplementTabletOralRheingold Food International Ltd.1994-12-312007-07-26Canada
Vita B Complex TabTabletOralNutrimetics International (Canada) Inc.1985-12-312000-07-19Canada
Vita Day TabTabletOralJamieson Laboratories Ltd1993-12-311997-08-13Canada
Vita-BTabletOralNutri Dyn Products Ltd.1984-12-311997-08-22Canada
Vita-B-75 CapCapsuleOralLes Laboratoires Vachon Inc.1989-12-311998-09-28Canada
Vita-folic-B CapsCapsuleOralLes Laboratoires Vachon Inc.1990-12-311997-08-08Canada
Vita-worth B-complex TabletsTabletOralGeneral Nutrition Canada Inc.1997-04-182005-08-05Canada
Vitabanks Vitamin TabTabletOralVitabank Inc.1990-12-311997-05-30Canada
Vitachrom GcTabletOralNikken Usa, Incorporated2000-08-302007-10-01Canada
Vitaflex Dietary SuplementTabletOralHome Shopping Network DirectNot applicableNot applicableCanada
Vitafol CapletCapsuleOralEverett Laboratories, Inc.1985-05-01Not applicableUs
Vitafol NanoTablet, coatedOralEverett Laboratories, Inc.2014-07-14Not applicableUs
Vitafol OB CapletTabletOralExeltis Usa, Inc.2002-12-02Not applicableUs
Vitafol OneCapsule, gelatin coatedOralEverett Laboratories, Inc.2011-06-13Not applicableUs
Vitafol PlusCapsule, liquid filledOralEverett Laboratories, Inc.2012-04-23Not applicableUs
Vitafol UltraCapsule, liquid filledOralExeltis Usa, Inc.2013-09-23Not applicableUs
Vitalife - CapsuleCapsuleOralHolista Health (Canada) Inc.1996-11-132002-08-06Canada
Vitamin B + C CapCapsuleOralFinlandia Consultants1990-12-311997-12-02Canada
Vitamin B Complex 100 TabTabletOralBioforce Canada Inc.1994-12-311997-04-04Canada
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Vitamin B Complex SupplTabletOralAvacare, Division Of Jeunique International Inc.1985-12-312006-07-20Canada
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Vitamin B Complex W C TabTabletOralAlbi Imports Ltd.1979-12-312004-09-24Canada
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Vitamin B TabletsTabletOralWeider Health Products1985-12-311999-09-09Canada
Vitamin B-12 With Folic Acid TabletsTabletOralGeneral Nutrition Canada Inc.1997-04-182005-08-05Canada
Vitamin B12 Plus Tablets W Folic AcidTabletOralNu Life Nutrition Ltd.1986-12-312005-03-15Canada
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Categories
UNII
935E97BOY8
CAS number
59-30-3
Weight
Average: 441.3975
Monoisotopic: 441.139681375
Chemical Formula
C19H19N7O6
InChI Key
OVBPIULPVIDEAO-LBPRGKRZSA-N
InChI
InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
IUPAC Name
(2S)-2-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid
SMILES
NC1=NC(=O)C2=NC(CNC3=CC=C(C=C3)C(=O)N[[email protected]@H](CCC(O)=O)C(O)=O)=CN=C2N1

Pharmacology

Indication

For treatment of folic acid deficiency, megaloblastic anemia and in anemias of nutritional supplements, pregnancy, infancy, or childhood.

Structured Indications
Not Available
Pharmacodynamics

Folic acid, a water-soluble B-complex vitamin, is found in foods such as liver, kidneys, yeast, and leafy, green vegetables. Folic acid is used to diagnose folate deficiency and to treat topical sprue and megaloblastic and macrocytic anemias, hematologic complications resulting from a deficiency in folic acid.

Mechanism of action

Folic acid, as it is biochemically inactive, is converted to tetrahydrofolic acid and methyltetrahydrofolate by dihydrofolate reductase. These folic acid congeners are transported across cells by receptor-mediated endocytosis where they are needed to maintain normal erythropoiesis, synthesize purine and thymidylate nucleic acids, interconvert amino acids, methylate tRNA, and generate and use formate. Using vitamin B12 as a cofactor, folic acid can normalize high homocysteine levels by remethylation of homocysteine to methionine via methionine synthetase.

TargetActionsOrganism
UFolate receptor beta
binder
Human
UFolate receptor gamma
binder
Human
UFolate receptor alphaNot AvailableHuman
Absorption
Not Available
Volume of distribution
Not Available
Protein binding

Very high to plasma protein

Metabolism

Hepatic

Route of elimination

Folic Acid is metabolized in the liver to 7, 8-dihydrofolic acid and eventually to 5,6,7,8-tetrahydrofolic acid with the aid of reduced diphosphopyridine nucleotide (DPNH) and folate reductases. A majority of the metabolic products appeared in the urine after 6 hours; excretion was generally complete within 24 hours. Folic Acid is also excreted in the milk of lactating mothers.

Half life
Not Available
Clearance
Not Available
Toxicity

IPR-MUS LD50 85 mg/kg,IVN-GPG LD50 120 mg/kg, IVN-MUS LD50 239 mg/kg, IVN-RAT LD50 500 mg/kg, IVN-RBT LD50 410 mg/kg

Affected organisms
  • Humans and other mammals
Pathways
PathwayCategory
Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)Disease
Methotrexate Action PathwayDrug action
Folate MetabolismMetabolic
Folate malabsorption, hereditaryDisease
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
AceclofenacThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Aceclofenac.Approved
Acetylsalicylic acidThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Acetylsalicylic acid.Approved, Vet Approved
AdapaleneThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Adapalene.Approved
AndrographolideThe therapeutic efficacy of Folic Acid can be decreased when used in combination with HMPL-004.Investigational
AnisodamineThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Anisodamine.Investigational
AntipyrineThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Antipyrine.Approved
ApocyninThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Acetovanillone.Investigational
ApremilastThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Apremilast.Approved, Investigational
AzapropazoneThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Azapropazone.Withdrawn
AzelastineThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Azelastine.Approved
BalsalazideThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Balsalazide.Approved, Investigational
BenoxaprofenThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Benoxaprofen.Withdrawn
Betulinic AcidThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Betulinic Acid.Investigational
BromfenacThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Bromfenac.Approved
BucillamineThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Bucillamine.Investigational
CarprofenThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Carprofen.Approved, Vet Approved, Withdrawn
CastanospermineThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Castanospermine.Experimental
CelecoxibThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Celecoxib.Approved, Investigational
ChloroquineThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Chloroquine.Approved, Vet Approved
Choline magnesium trisalicylateThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Trisalicylate-choline.Approved
ClonixinThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Clonixin.Approved
ClotrimazoleThe metabolism of Folic Acid can be decreased when combined with Clotrimazole.Approved, Vet Approved
CurcuminThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Curcumin.Investigational
Cyproterone acetateThe serum concentration of Folic Acid can be decreased when it is combined with Cyproterone acetate.Approved, Investigational
D-LimoneneThe therapeutic efficacy of Folic Acid can be decreased when used in combination with D-Limonene.Investigational
DiclofenacThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Diclofenac.Approved, Vet Approved
DiflunisalThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Diflunisal.Approved
DisulfiramThe metabolism of Folic Acid can be decreased when combined with Disulfiram.Approved
DroxicamThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Droxicam.Approved
DuvelisibThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Duvelisib.Investigational
E-6201The therapeutic efficacy of Folic Acid can be decreased when used in combination with E6201.Investigational
EbselenThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Ebselen.Investigational
EltrombopagThe serum concentration of Folic Acid can be increased when it is combined with Eltrombopag.Approved
EpirizoleThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Epirizole.Approved
EtanerceptThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Etanercept.Approved, Investigational
EtodolacThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Etodolac.Approved, Investigational, Vet Approved
EtofenamateThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Etofenamate.Approved
EtoricoxibThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Etoricoxib.Approved, Investigational
Evening primrose oilThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Evening primrose oil.Approved
exisulindThe therapeutic efficacy of Folic Acid can be decreased when used in combination with exisulind.Investigational
FenbufenThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Fenbufen.Approved
FenoprofenThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Fenoprofen.Approved
FloctafenineThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Floctafenine.Approved, Withdrawn
FlunixinThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Flunixin.Vet Approved
FlurbiprofenThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Flurbiprofen.Approved, Investigational
FosphenytoinThe serum concentration of Fosphenytoin can be decreased when it is combined with Folic Acid.Approved
HigenamineThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Higenamine.Investigational
IbuprofenThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Ibuprofen.Approved
IbuproxamThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Ibuproxam.Withdrawn
IcatibantThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Icatibant.Approved
IndomethacinThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Indomethacin.Approved, Investigational
IndoprofenThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Indoprofen.Withdrawn
IsoniazidThe metabolism of Folic Acid can be decreased when combined with Isoniazid.Approved
IsoxicamThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Isoxicam.Withdrawn
KebuzoneThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Kebuzone.Experimental
KetoprofenThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Ketoprofen.Approved, Vet Approved
KetorolacThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Ketorolac.Approved
LeflunomideThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Leflunomide.Approved, Investigational
LisofyllineThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Lisofylline.Investigational
LornoxicamThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Lornoxicam.Approved
LoxoprofenThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Loxoprofen.Approved
LumiracoxibThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Lumiracoxib.Approved, Investigational
Magnesium salicylateThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Magnesium salicylate.Approved
MasoprocolThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Masoprocol.Approved
Meclofenamic acidThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Meclofenamic acid.Approved, Vet Approved
Mefenamic acidThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Mefenamic acid.Approved
MeloxicamThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Meloxicam.Approved, Vet Approved
MesalazineThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Mesalazine.Approved
MetamizoleThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Metamizole.Withdrawn
MizoribineThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Mizoribine.Investigational
Mycophenolate mofetilThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Mycophenolate mofetil.Approved, Investigational
Mycophenolic acidThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Mycophenolic acid.Approved
NabumetoneThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Nabumetone.Approved
NafamostatThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Nafamostat.Approved, Investigational
NaftifineThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Naftifine.Approved
NaproxenThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Naproxen.Approved, Vet Approved
NepafenacThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Nepafenac.Approved
NicotineThe metabolism of Folic Acid can be decreased when combined with Nicotine.Approved
Niflumic AcidThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Niflumic Acid.Approved
NimesulideThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Nimesulide.Approved, Withdrawn
NitroaspirinThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Nitroaspirin.Investigational
OlopatadineThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Olopatadine.Approved
OlsalazineThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Olsalazine.Approved
OrgoteinThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Orgotein.Vet Approved
OxaprozinThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Oxaprozin.Approved
OxyphenbutazoneThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Oxyphenbutazone.Withdrawn
ParecoxibThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Parecoxib.Approved
PhenobarbitalThe serum concentration of Phenobarbital can be decreased when it is combined with Folic Acid.Approved
PhenylbutazoneThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Phenylbutazone.Approved, Vet Approved
PhenytoinThe serum concentration of Phenytoin can be decreased when it is combined with Folic Acid.Approved, Vet Approved
PimecrolimusThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Pimecrolimus.Approved, Investigational
PirfenidoneThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Pirfenidone.Investigational
PiroxicamThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Piroxicam.Approved, Investigational
PrimidoneThe serum concentration of Primidone can be decreased when it is combined with Folic Acid.Approved, Vet Approved
PropacetamolThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Propacetamol.Approved
PTC299The therapeutic efficacy of Folic Acid can be decreased when used in combination with PTC299.Investigational
RaltitrexedThe therapeutic efficacy of Raltitrexed can be decreased when used in combination with Folic Acid.Approved, Investigational
ResveratrolThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Resveratrol.Experimental, Investigational
RofecoxibThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Rofecoxib.Investigational, Withdrawn
RolapitantThe serum concentration of Folic Acid can be increased when it is combined with Rolapitant.Approved
SalicylamideThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Salicylamide.Approved
Salicylic acidThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Salicylic acid.Approved, Vet Approved
SalsalateThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Salsalate.Approved
SeratrodastThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Seratrodast.Approved
SRT501The therapeutic efficacy of Folic Acid can be decreased when used in combination with SRT501.Investigational
SulfasalazineThe serum concentration of Folic Acid can be decreased when it is combined with Sulfasalazine.Approved
SulindacThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Sulindac.Approved
SuprofenThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Suprofen.Approved, Withdrawn
TenoxicamThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Tenoxicam.Approved
TepoxalinThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Tepoxalin.Vet Approved
TeriflunomideThe serum concentration of Folic Acid can be increased when it is combined with Teriflunomide.Approved
Tiaprofenic acidThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Tiaprofenic acid.Approved
TiclopidineThe metabolism of Folic Acid can be decreased when combined with Ticlopidine.Approved
TinoridineThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Tinoridine.Investigational
Tolfenamic AcidThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Tolfenamic Acid.Approved
TolmetinThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Tolmetin.Approved
TranilastThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Tranilast.Approved, Investigational
ValdecoxibThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Valdecoxib.Investigational, Withdrawn
ZaltoprofenThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Zaltoprofen.Approved
ZileutonThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Zileuton.Approved, Investigational, Withdrawn
ZomepiracThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Zomepirac.Withdrawn
Food Interactions
Not Available

References

Synthesis Reference

Carroll G. Temple, Jr., Robert D. Elliott, Jerry D. Rose, John A. Montgomery, "Preparation of tetrahydrofolic acid from folic acid." U.S. Patent US4206307, issued April, 1956.

US4206307
General References
  1. Kamen B: Folate and antifolate pharmacology. Semin Oncol. 1997 Oct;24(5 Suppl 18):S18-30-S18-39. [PubMed:9420019 ]
  2. Fenech M, Aitken C, Rinaldi J: Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults. Carcinogenesis. 1998 Jul;19(7):1163-71. [PubMed:9683174 ]
  3. Zittoun J: [Anemias due to disorder of folate, vitamin B12 and transcobalamin metabolism]. Rev Prat. 1993 Jun 1;43(11):1358-63. [PubMed:8235383 ]
  4. Alaimo K, McDowell MA, Briefel RR, Bischof AM, Caughman CR, Loria CM, Johnson CL: Dietary intake of vitamins, minerals, and fiber of persons ages 2 months and over in the United States: Third National Health and Nutrition Examination Survey, Phase 1, 1988-91. Adv Data. 1994 Nov 14;(258):1-28. [PubMed:10138938 ]
  5. Raiten DJ, Fisher KD: Assessment of folate methodology used in the Third National Health and Nutrition Examination Survey (NHANES III, 1988-1994). J Nutr. 1995 May;125(5):1371S-1398S. [PubMed:7738698 ]
External Links
Human Metabolome Database
HMDB00121
KEGG Drug
D00070
KEGG Compound
C00504
PubChem Compound
6037
PubChem Substance
46508092
ChemSpider
5815
BindingDB
50367343
ChEBI
27470
ChEMBL
CHEMBL1622
Therapeutic Targets Database
DAP001309
PharmGKB
PA449692
HET
FOL
Drugs.com
Drugs.com Drug Page
PDRhealth
PDRhealth Drug Page
Wikipedia
Folic_Acid
ATC Codes
B03AE02 — Iron, multivitamins and folic acidB03AE01 — Iron, vitamin b12 and folic acidB03BB51 — Folic acid, combinationsB03BB01 — Folic acid
AHFS Codes
  • 88:08.00
PDB Entries
FDA label
Not Available
MSDS
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Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1Active Not RecruitingTreatmentAdvanced Non-Small Cell Lung Cancer (NSCLC) / Cancer, Ovarian / Non Small Cell Lung Carcinoma (NSCLC) / Triple-Negative Breast Cancer (TNBC) / Tumors, Solid1
1CompletedNot AvailableHuman Immunodeficiency Virus (HIV) Infections / Infection, Human Immunodeficiency Virus I / Mycobacterium avium complex infection1
1CompletedDiagnosticHealthy Volunteers1
1CompletedOtherHeart Rate / Heart Rate Variability / Inflammatory Reaction1
1CompletedPreventionHIV/AIDS1
1CompletedPreventionHealthy Volunteers / Pharmacokinetics1
1CompletedPreventionRecurrent Neural Tube Defects1
1CompletedTreatmentCancers / Metastases1
1CompletedTreatmentHealthy Volunteers1
1CompletedTreatmentRheumatoid Arthritis2
1Not Yet RecruitingBasic ScienceAging / Mineral deficiency / Vitamin Deficiency1
1RecruitingBasic ScienceOvary Cancer1
1RecruitingDiagnosticMetastatic Cancer Lung / Ovarian Cancer Metastatic1
1, 2Not Yet RecruitingTreatmentCecal Neoplasms / Metastases to peritoneum / Neoplasms, Colorectal / Peritoneal Carcinomatosis1
1, 2RecruitingTreatmentPolycystic Ovaries Syndrome1
1, 2RecruitingTreatmentPostpartum Anemia1
1, 2SuspendedTreatmentSchizoaffective Disorders / Schizophrenic Disorders1
1, 2TerminatedTreatmentPsoriasis1
2Active Not RecruitingTreatmentAtherosclerosis / HIV Disease / Inflammatory Reaction1
2Active Not RecruitingTreatmentLung Cancers / Neoplasms Metastasis1
2Active Not RecruitingTreatmentRheumatoid Arthritis1
2CompletedPreventionAdenoma benign / Colorectal Polyps / Malignant Neoplasm of Colon1
2CompletedPreventionDepressive Disorders / Depressive State1
2CompletedPreventionHuman Immunodeficiency Virus (HIV) Infections1
2CompletedTreatmentChronic Arsenic Poisoning1
2CompletedTreatmentHead and Neck Carcinoma1
2CompletedTreatmentLupus / Systemic Lupus Erythematosus (SLE)1
2CompletedTreatmentNon-Small-Cell Lung Carcinoma (NSCLC)1
2CompletedTreatmentRheumatoid Arthritis4
2Not Yet RecruitingTreatmentRheumatoid Arthritis1
2RecruitingPreventionPeripheral T-cell lymphoma unspecified refractory / Relapsed Peripheral T-Cell Lymphoma1
2RecruitingTreatmentHIV Disease1
2RecruitingTreatmentHuman Immunodeficiency Virus (HIV) Infections1
2RecruitingTreatmentMetastatic Colorectal Cancers1
2RecruitingTreatmentRheumatoid Arthritis3
2TerminatedTreatmentInfertilities1
2Unknown StatusPreventionArsenic Poisoning / Toxic Effect of Arsenic and Its Compounds1
2Unknown StatusPreventionCoronary Artery Disease1
2Unknown StatusTreatmentAfter Resection of Liver Metastases / Colorectal Cancers / KRAS Wildtype1
2Unknown StatusTreatmentAnemias1
2WithdrawnTreatmentNeoplasms, Breast1
2, 3CompletedPreventionAdenoma benign / Colorectal Cancers / Polyps1
2, 3CompletedTreatmentAtherosclerosis1
2, 3CompletedTreatmentCardiovascular Disease (CVD) / Chronic Kidney Disease (CKD) / Mortality1
2, 3CompletedTreatmentDiabetic Nephropathies1
2, 3CompletedTreatmentRheumatoid Arthritis1
2, 3RecruitingPreventionDiabetes, Gestational / Polycystic Ovaries Syndrome1
2, 3RecruitingPreventionNeoplasms, Colorectal1
3CompletedPreventionCleft Lip / Cleft Palates1
3CompletedPreventionComplications, Pregnancy / PreEclampsia1
3CompletedPreventionGingival Overgrowth1
3CompletedPreventionPlasmodium Infections1
3CompletedTreatmentActive Rheumatoid Arthritis1
3CompletedTreatmentAlzheimer's Disease (AD)1
3CompletedTreatmentAnemias1
3CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Tuberculosis, Pulmonary1
3CompletedTreatmentMale Infertility1
3CompletedTreatmentMycobacterium Tuberculosis1
3CompletedTreatmentNon-Small-Cell Lung Carcinoma (NSCLC)1
3CompletedTreatmentRheumatoid Arthritis5
3CompletedTreatmentSystemic Lupus Erythematosus (SLE)1
3RecruitingTreatmentBladder Cancers / Transitional Cell Carcinoma / Ureteral Cancer1
3RecruitingTreatmentRheumatoid Arthritis1
3TerminatedPreventionBlood Loss / Pregnancy termination therapy1
3Unknown StatusNot AvailableAnemias / Low Birth Weight / Neonatal Mortality1
3Unknown StatusPreventionCongenital Malformations1
3Unknown StatusPreventionEpilepsies1
3Unknown StatusTreatmentAlzheimer's Disease (AD) / Down Syndrome (DS)1
4Active Not RecruitingBasic SciencePsoriasis1
4CompletedNot AvailableMetabolic Syndromes1
4CompletedPreventionAnovulatory cycle / Polycystic Ovaries Syndrome1
4CompletedPreventionCardiovascular Disease (CVD) / Chronic Renal Failure (CRF) / Hemodialysis-dependent patients / Hyperhomocysteinaemia / Uremia1
4CompletedPreventionPostpartum Hemorrhage1
4CompletedTreatmentBMI >30 kg/m2 / Hyperhomocysteinaemia1
4CompletedTreatmentDepressive State1
4CompletedTreatmentDiabetic Peripheral Neuropathic Pain1
4CompletedTreatmentHyperemesis Gravidarum / Morning Sickness / Nausea / Pregnancy / Vomiting1
4CompletedTreatmentHyperpigmentation1
4CompletedTreatmentNegative Symptoms / Schizophrenic Disorders1
4CompletedTreatmentPregnancy1
4CompletedTreatmentRecurrent Miscarriages1
4CompletedTreatmentRheumatoid Arthritis2
4CompletedTreatmentSchizophrenic Disorders1
4CompletedTreatmentUnipolar Depression1
4Not Yet RecruitingTreatmentFaltering Growth / Primary Malnurtrition1
4RecruitingPreventionKidney Diseases / Urologic Diseases1
4RecruitingTreatmentHuman Immunodeficiency Virus (HIV) Infections1
4RecruitingTreatmentRheumatoid Arthritis1
4TerminatedDiagnosticTransplantation, Kidney1
4TerminatedTreatmentAnemias1
4TerminatedTreatmentHeart Failure, Unspecified1
4TerminatedTreatmentRheumatoid Arthritis1
4Unknown StatusNot AvailableDiabetes, Gestational1
4Unknown StatusTreatmentNonulcer Dyspepsia1
4WithdrawnTreatmentNephritis / Proteinuria / Systemic Lupus Erythematosus (SLE)1
Not AvailableCompletedNot AvailableAnemias1
Not AvailableCompletedNot AvailableHuman Immunodeficiency Virus (HIV) Infections1
Not AvailableCompletedDiagnosticCoronary Artery Disease / Major Surgery1
Not AvailableCompletedPreventionBipolar Disorder (BD) / Depressive State1
Not AvailableCompletedPreventionNeural Tube Defects (NTDs)1
Not AvailableCompletedPreventionNeural Tube Defects - Spina Bifida and Anencephaly1
Not AvailableCompletedPreventionSpina Bifida and Anencephaly1
Not AvailableCompletedTreatmentAcute Myocardial Infarction (AMI)1
Not AvailableCompletedTreatmentDiabetic Nephropathies / Hyperhomocysteinaemia1
Not AvailableCompletedTreatmentEnd Stage Renal Disease (ESRD) / Hyperhomocysteinaemia1
Not AvailableCompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections1
Not AvailableCompletedTreatmentHyperandrogenism / Menstrual Pattern / Metabolic Features / Polycystic Ovaries Syndrome1
Not AvailableCompletedTreatmentHyperhomocysteinaemia / Inflammatory Reaction / Mortality1
Not AvailableNot Yet RecruitingTreatmentBreast Cancer Metastatic / Metastatic Breast Cancer (MBC)1
Not AvailableTerminatedTreatmentAbortion, Therapeutic / Pregnancy Trimester, Second1
Not AvailableUnknown StatusTreatmentAbnormal Uterine Bleeding Unrelated to Menstrual Cycle1
Not AvailableUnknown StatusTreatmentFolic acid antagonist overdose1
Not AvailableWithdrawnPreventionStrokes / Transient Ischaemic Attack (TIA)1

Pharmacoeconomics

Manufacturers
  • App pharmaceuticals llc
  • Ben venue laboratories inc
  • Wyeth pharmaceuticals inc
  • Barr laboratories inc
  • Cadista pharmaceuticals inc
  • Contract pharmacal corp
  • Everylife
  • Excellium pharmaceutical inc
  • Halsey drug co inc
  • Impax laboratories inc
  • Invagen pharmaceuticals inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Lannett co inc
  • Eli lilly and co
  • Mk laboratories inc
  • Mutual pharmaceutical co inc
  • Nexgen pharma inc
  • Pharmax group inc
  • Pharmeral inc
  • Pioneer pharmaceuticals inc
  • Purepac pharmaceutical co
  • Sandoz inc
  • Tablicaps inc
  • Udl laboratories inc
  • Usl pharma inc
  • Valeant pharmaceuticals international
  • Vangard laboratories inc div midway medical co
  • Vintage pharmaceuticals llc
  • Vintage pharmaceuticals inc
  • Watson laboratories
  • Watson laboratories inc
  • West ward pharmaceutical corp
  • Whiteworth towne paulsen inc
  • Mission pharmacal co
Packagers
Dosage forms
FormRouteStrength
TabletOral5 mg
Tablet, extended releaseOral
SolutionOral
TabletOral
Granule, effervescentOral
WaferOral
Kit
Tablet, effervescentOral
Capsule, delayed release pelletsOral
Tablet, film coatedOral
LiquidOral
Injection, solutionIntramuscular; Intravenous; Subcutaneous5 mg/mL
TabletOral1 mg/1
TabletOral0.4 mg
TabletOral1 mg
TabletOral1.0 mg
TabletOral.4 mg
TabletOral.8 mg
CapsuleOral1 mg
Tablet, extended releaseOral800 mcg
SolutionIntramuscular; Intravenous; Subcutaneous5 mg
LiquidIntramuscular; Intravenous; Subcutaneous5 mg
TabletOral25 mg
TabletOral0.8 mg
PowderOral
Tablet, chewableOral
Solution / dropsOral
LiquidIntravenous
Injection, powder, lyophilized, for solutionIntravenous
SolutionIntravenous
Capsule, gelatin coatedOral
CapsuleOral
Injection, solutionIntravenous
Tablet, coatedOral
Powder, for solutionOral
KitOral
LozengeOral
Capsule, extended releaseOral
Capsule, liquid filledOral
Prices
Unit descriptionCostUnit
Folic acid 5 mg/ml vial2.14USD ml
Folic Acid 5 mg/ml2.04USD ml
Folic acid powder1.68USD g
Folvite 5 mg/ml vial1.38USD ml
Folic Acid 1 mg tablet0.15USD tablet
Folic acid 400 mcg tablet0.07USD tablet
Apo-Folic 5 mg Tablet0.04USD tablet
CVS Pharmacy folic acid 800 mcg tablet0.02USD tablet
Folic acid 0.4 mg tablet0.02USD tablet
Folic acid 0.8 mg tablet0.02USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)250 dec °CPhysProp
water solubility1.6 mg/L (at 25 °C)MERCK INDEX (1983)
logP-2.5Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0761 mg/mLALOGPS
logP-0.04ALOGPS
logP-0.68ChemAxon
logS-3.8ALOGPS
pKa (Strongest Acidic)3.37ChemAxon
pKa (Strongest Basic)2.09ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count12ChemAxon
Hydrogen Donor Count6ChemAxon
Polar Surface Area208.99 Å2ChemAxon
Rotatable Bond Count9ChemAxon
Refractivity111.01 m3·mol-1ChemAxon
Polarizability42.06 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.7956
Blood Brain Barrier+0.7609
Caco-2 permeable-0.844
P-glycoprotein substrateSubstrate0.687
P-glycoprotein inhibitor INon-inhibitor0.9795
P-glycoprotein inhibitor IINon-inhibitor0.9969
Renal organic cation transporterNon-inhibitor0.876
CYP450 2C9 substrateNon-substrate0.8276
CYP450 2D6 substrateNon-substrate0.7947
CYP450 3A4 substrateNon-substrate0.6212
CYP450 1A2 substrateNon-inhibitor0.9281
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.9435
CYP450 2C19 inhibitorNon-inhibitor0.916
CYP450 3A4 inhibitorNon-inhibitor0.9075
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.974
Ames testNon AMES toxic0.8724
CarcinogenicityNon-carcinogens0.9521
BiodegradationNot ready biodegradable0.9191
Rat acute toxicity2.4490 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9529
hERG inhibition (predictor II)Non-inhibitor0.8444
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)LC-MS/MSsplash10-0006-0000900000-4208ea3c2f5d9026c19f
LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)LC-MS/MSsplash10-0006-0050900000-2c8ad037dc3b270765c4
LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)LC-MS/MSsplash10-0007-0090300000-ebdec84cbb7fe5afbc0b
LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , NegativeLC-MS/MSsplash10-0007-0903600000-e5d91e4f2ab79d130b76
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-QTOF , negativeLC-MS/MSsplash10-0007-0903600000-e5d91e4f2ab79d130b76
LC-MS/MS Spectrum - , positiveLC-MS/MSsplash10-002b-0960000000-108d96993dc78f1e4b61
Predicted LC-MS/MS Spectrum - 10V, PositivePredicted LC-MS/MSNot Available
Predicted LC-MS/MS Spectrum - 20V, PositivePredicted LC-MS/MSNot Available
Predicted LC-MS/MS Spectrum - 40V, PositivePredicted LC-MS/MSNot Available
Predicted LC-MS/MS Spectrum - 10V, NegativePredicted LC-MS/MSNot Available
Predicted LC-MS/MS Spectrum - 20V, NegativePredicted LC-MS/MSNot Available
Predicted LC-MS/MS Spectrum - 40V, NegativePredicted LC-MS/MSNot Available
Mass Spectrum (Electron Ionization)MSsplash10-0006-9410000000-7cba521e870757539424
1H NMR Spectrum1D NMRNot applicable
1H NMR Spectrum1D NMRNot applicable
13C NMR Spectrum1D NMRNot applicable
1H NMR Spectrum1D NMRNot applicable
13C NMR Spectrum1D NMRNot applicable
[1H,13C] 2D NMR Spectrum2D NMRNot applicable

Taxonomy

Description
This compound belongs to the class of chemical entities known as glutamic acid and derivatives. These are compounds containing glutamic acid or a derivative thereof resulting from reaction of glutamic acid at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
Kingdom
Chemical entities
Super Class
Organic compounds
Class
Organic acids and derivatives
Sub Class
Carboxylic acids and derivatives
Direct Parent
Glutamic acid and derivatives
Alternative Parents
N-acyl-alpha amino acids / Hippuric acids / Pterins and derivatives / Aminobenzamides / Phenylalkylamines / Aniline and substituted anilines / Benzoyl derivatives / Secondary alkylarylamines / Hydroxypyrimidines / Pyrazines
show 10 more
Substituents
Glutamic acid or derivatives / N-acyl-alpha-amino acid / N-acyl-alpha amino acid or derivatives / Hippuric acid / Hippuric acid or derivatives / Pterin / Aminobenzamide / Aminobenzoic acid or derivatives / Pteridine / Benzamide
show 30 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
N-acyl-amino acid, folic acids (CHEBI:27470 ) / Water-soluble vitamins (C00504 )

Targets

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Binder
General Function
Methotrexate binding
Specific Function
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analo...
Gene Name
FOLR2
Uniprot ID
P14207
Uniprot Name
Folate receptor beta
Molecular Weight
29279.31 Da
References
  1. Dixit V, Van den Bossche J, Sherman DM, Thompson DH, Andres RP: Synthesis and grafting of thioctic acid-PEG-folate conjugates onto Au nanoparticles for selective targeting of folate receptor-positive tumor cells. Bioconjug Chem. 2006 May-Jun;17(3):603-9. [PubMed:16704197 ]
  2. Wlodarczyk BJ, Cabrera RM, Hill DS, Bozinov D, Zhu H, Finnell RH: Arsenic-induced gene expression changes in the neural tube of folate transport defective mouse embryos. Neurotoxicology. 2006 Jul;27(4):547-57. Epub 2006 Apr 18. [PubMed:16620997 ]
  3. Boyles AL, Billups AV, Deak KL, Siegel DG, Mehltretter L, Slifer SH, Bassuk AG, Kessler JA, Reed MC, Nijhout HF, George TM, Enterline DS, Gilbert JR, Speer MC: Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions. Environ Health Perspect. 2006 Oct;114(10):1547-52. [PubMed:17035141 ]
  4. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Binder
General Function
Folic acid binding
Specific Function
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform Short does not bind folate.
Gene Name
FOLR3
Uniprot ID
P41439
Uniprot Name
Folate receptor gamma
Molecular Weight
27638.0 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Shen F, Ross JF, Wang X, Ratnam M: Identification of a novel folate receptor, a truncated receptor, and receptor type beta in hematopoietic cells: cDNA cloning, expression, immunoreactivity, and tissue specificity. Biochemistry. 1994 Feb 8;33(5):1209-15. [PubMed:8110752 ]
  4. Shen F, Wu M, Ross JF, Miller D, Ratnam M: Folate receptor type gamma is primarily a secretory protein due to lack of an efficient signal for glycosylphosphatidylinositol modification: protein characterization and cell type specificity. Biochemistry. 1995 Apr 25;34(16):5660-5. [PubMed:7727426 ]
  5. Prasad PD, Ramamoorthy S, Moe AJ, Smith CH, Leibach FH, Ganapathy V: Selective expression of the high-affinity isoform of the folate receptor (FR-alpha) in the human placental syncytiotrophoblast and choriocarcinoma cells. Biochim Biophys Acta. 1994 Aug 11;1223(1):71-5. [PubMed:8061055 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Receptor activity
Specific Function
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analo...
Gene Name
FOLR1
Uniprot ID
P15328
Uniprot Name
Folate receptor alpha
Molecular Weight
29818.94 Da
References
  1. Wang L, Desmoulin SK, Cherian C, Polin L, White K, Kushner J, Fulterer A, Chang MH, Mitchell-Ryan S, Stout M, Romero MF, Hou Z, Matherly LH, Gangjee A: Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits beta-glycinamide ribonucleotide formyltransferase. J Med Chem. 2011 Oct 27;54(20):7150-64. doi: 10.1021/jm200739e. Epub 2011 Sep 22. [PubMed:21879757 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic ...
Gene Name
CYP2E1
Uniprot ID
P05181
Uniprot Name
Cytochrome P450 2E1
Molecular Weight
56848.42 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Omega peptidase activity
Specific Function
Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and fr...
Gene Name
GGH
Uniprot ID
Q92820
Uniprot Name
Gamma-glutamyl hydrolase
Molecular Weight
35964.045 Da
References
  1. Schneider E, Ryan TJ: Gamma-glutamyl hydrolase and drug resistance. Clin Chim Acta. 2006 Dec;374(1-2):25-32. Epub 2006 Jun 10. [PubMed:16859665 ]
  2. Eisele LE, Chave KJ, Lehning AC, Ryan TJ: Characterization of Human gamma-glutamyl hydrolase in solution demonstrates that the enzyme is a non-dissociating homodimer. Biochim Biophys Acta. 2006 Sep;1764(9):1479-86. Epub 2006 Jul 12. [PubMed:16945597 ]
  3. Chen L, Eitenmiller RR: Optimization of the trienzyme extraction for the microbiological assay of folate in vegetables. J Agric Food Chem. 2007 May 16;55(10):3884-8. Epub 2007 Apr 17. [PubMed:17439143 ]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Protein complex binding
Specific Function
Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine.
Gene Name
MTHFR
Uniprot ID
P42898
Uniprot Name
Methylenetetrahydrofolate reductase
Molecular Weight
74595.895 Da
References
  1. West AA, Caudill MA: Genetic variation: impact on folate (and choline) bioefficacy. Int J Vitam Nutr Res. 2010 Oct;80(4-5):319-29. doi: 10.1024/0300-9831/a000040. [PubMed:21462116 ]
  2. Kim YI: Role of the MTHFR polymorphisms in cancer risk modification and treatment. Future Oncol. 2009 May;5(4):523-42. doi: 10.2217/fon.09.26. [PubMed:19450180 ]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Toxic substance binding
Specific Function
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloid...
Gene Name
ALB
Uniprot ID
P02768
Uniprot Name
Serum albumin
Molecular Weight
69365.94 Da
References
  1. Christensen U, Holm J, Hansen SI: Stopped-flow kinetic studies of the interaction of bovine folate binding protein (FBP) and folate. Biosci Rep. 2006 Aug;26(4):291-9. [PubMed:17029005 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Organic anion transmembrane transporter activity
Specific Function
May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocyte...
Gene Name
ABCC3
Uniprot ID
O15438
Uniprot Name
Canalicular multispecific organic anion transporter 2
Molecular Weight
169341.14 Da
References
  1. Zeng H, Chen ZS, Belinsky MG, Rea PA, Kruh GD: Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. Cancer Res. 2001 Oct 1;61(19):7225-32. [PubMed:11585759 ]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Purine nucleotide transmembrane transporter activity
Specific Function
Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a ...
Gene Name
ABCC11
Uniprot ID
Q96J66
Uniprot Name
ATP-binding cassette sub-family C member 11
Molecular Weight
154299.625 Da
References
  1. Chen ZS, Guo Y, Belinsky MG, Kotova E, Kruh GD: Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11). Mol Pharmacol. 2005 Feb;67(2):545-57. Epub 2004 Nov 10. [PubMed:15537867 ]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Atpase activity, coupled to transmembrane movement of substances
Specific Function
May be an organic anion pump relevant to cellular detoxification.
Gene Name
ABCC4
Uniprot ID
O15439
Uniprot Name
Multidrug resistance-associated protein 4
Molecular Weight
149525.33 Da
References
  1. Chen ZS, Lee K, Walther S, Raftogianis RB, Kuwano M, Zeng H, Kruh GD: Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. Cancer Res. 2002 Jun 1;62(11):3144-50. [PubMed:12036927 ]
  2. Rius M, Nies AT, Hummel-Eisenbeiss J, Jedlitschky G, Keppler D: Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. Hepatology. 2003 Aug;38(2):374-84. [PubMed:12883481 ]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Sodium-independent organic anion transmembrane transporter activity
Specific Function
Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one ...
Gene Name
SLC22A6
Uniprot ID
Q4U2R8
Uniprot Name
Solute carrier family 22 member 6
Molecular Weight
61815.78 Da
References
  1. Kuze K, Graves P, Leahy A, Wilson P, Stuhlmann H, You G: Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells. J Biol Chem. 1999 Jan 15;274(3):1519-24. [PubMed:9880528 ]
  2. Uwai Y, Okuda M, Takami K, Hashimoto Y, Inui K: Functional characterization of the rat multispecific organic anion transporter OAT1 mediating basolateral uptake of anionic drugs in the kidney. FEBS Lett. 1998 Nov 6;438(3):321-4. [PubMed:9827570 ]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Xenobiotic-transporting atpase activity
Specific Function
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both fro...
Gene Name
ABCG2
Uniprot ID
Q9UNQ0
Uniprot Name
ATP-binding cassette sub-family G member 2
Molecular Weight
72313.47 Da
References
  1. Chen ZS, Robey RW, Belinsky MG, Shchaveleva I, Ren XQ, Sugimoto Y, Ross DD, Bates SE, Kruh GD: Transport of methotrexate, methotrexate polyglutamates, and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2: effects of acquired mutations at R482 on methotrexate transport. Cancer Res. 2003 Jul 15;63(14):4048-54. [PubMed:12874005 ]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Methotrexate transporter activity
Specific Function
Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithel...
Gene Name
SLC46A1
Uniprot ID
Q96NT5
Uniprot Name
Proton-coupled folate transporter
Molecular Weight
49770.04 Da
References
  1. Nakai Y, Inoue K, Abe N, Hatakeyama M, Ohta KY, Otagiri M, Hayashi Y, Yuasa H: Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter. J Pharmacol Exp Ther. 2007 Aug;322(2):469-76. Epub 2007 May 2. [PubMed:17475902 ]
  2. Ashokkumar B, Mohammed ZM, Vaziri ND, Said HM: Effect of folate oversupplementation on folate uptake by human intestinal and renal epithelial cells. Am J Clin Nutr. 2007 Jul;86(1):159-66. [PubMed:17616776 ]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Folic acid transporter activity
Specific Function
Transports folate across the inner membranes of mitochondria.
Gene Name
SLC25A32
Uniprot ID
Q9H2D1
Uniprot Name
Mitochondrial folate transporter/carrier
Molecular Weight
35406.83 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Drug created on June 13, 2005 07:24 / Updated on September 01, 2017 10:24