Benzylisoquinolines

Name
Benzylisoquinolines
Accession Number
DBCAT001091
Description

ISOQUINOLINES with a benzyl substituent.

Drugs
DrugDrug Description
Metocurine iodideFor use as an anesthesia adjunct to induce skeletal muscle relaxation and to reduce the intensity of muscle contractions in convulsive therapy.
CisatracuriumA skeletal muscle relaxant used to facilitate tracheal intubation, muscle relaxation in surgery, or mechanical ventilation.
ApomorphineA morphine derivative D2 dopamine agonist used to treat hypomobile "off" episodes of advanced Parkinson's disease.
Atracurium besylateA non-depolarizing neuromuscular blocker used to facilitate endotracheal intubation and relax skeletal muscles during surgery.
PapaverineAn alkaloid used to treat many types of smooth muscle spasms such as "vascular spasms" associated with acute myocardial infarction and angina pectoris, as well as "visceral spasms".
TubocurarineA neuromuscular blocker used for the diagnosis of and facilitation of intubation after induction of anesthesia during surgical procedures.
MetocurineMetocurine is a muscle relaxant.
BerberineAn alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal...
DrotaverineUsed in the treatment of functional bowel disorders and alleviating pain in renal colic.
BicucullineBicuculline is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and...
TetrahydropalmatineTetrahydropalmatine is under investigation in clinical trial NCT02118610 (Treatment of Schizophrenia With L-tetrahydropalmatine (l-THP): a Novel Dopamine Antagonist With Anti-inflammatory and Antiprotozoal Activity).
MoxaverineMoxaverine has been investigated for the treatment of Retina, Ocular Physiology, and Regional Blood Flow.
AtracuriumNot Annotated
AlcuroniumA non-depolarizing skeletal muscle relaxant similar to tubocurarine. It is used as an anesthesia adjuvant.
TretoquinolNot Annotated
Drugs & Drug Targets
DrugTargetType
Metocurine iodideNeuronal acetylcholine receptor subunit alpha-2target
CisatracuriumNeuronal acetylcholine receptor subunit alpha-2target
ApomorphineDopamine D2 receptortarget
ApomorphineDopamine D1 receptortarget
ApomorphineDopamine D4 receptortarget
ApomorphineDopamine D3 receptortarget
ApomorphineDopamine D5 receptortarget
ApomorphineAlpha-2C adrenergic receptortarget
ApomorphineAlpha-2B adrenergic receptortarget
Apomorphine5-hydroxytryptamine receptor 2Ctarget
Apomorphine5-hydroxytryptamine receptor 1Atarget
Apomorphine5-hydroxytryptamine receptor 2Atarget
Apomorphine5-hydroxytryptamine receptor 2Btarget
ApomorphineAlpha-2A adrenergic receptortarget
Apomorphine5-hydroxytryptamine receptor 1Dtarget
Apomorphine5-hydroxytryptamine receptor 1Btarget
ApomorphineCatechol O-methyltransferaseenzyme
ApomorphineSulfotransferase 1A1enzyme
ApomorphineSulfotransferase 1A2enzyme
ApomorphineSulfotransferase 1A3/1A4enzyme
ApomorphineEstrogen sulfotransferaseenzyme
ApomorphineSulfotransferase family cytosolic 1B member 1enzyme
ApomorphineCytochrome P450 2B6enzyme
ApomorphineCytochrome P450 2C8enzyme
ApomorphineCytochrome P450 3A4enzyme
ApomorphineCytochrome P450 3A5enzyme
ApomorphineUDP-glucuronosyltransferases (UGTs)enzyme
ApomorphineSerum albumincarrier
ApomorphineSynaptic vesicular amine transportertransporter
Atracurium besylateNeuronal acetylcholine receptor subunit alpha-2target
PapaverinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
PapaverinecAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Atarget
TubocurarineNeuronal acetylcholine receptor subunit alpha-2target
TubocurarineAcetylcholinesterasetarget
Tubocurarine5-hydroxytryptamine receptor 3Atarget
TubocurarineSolute carrier family 22 member 1transporter
TubocurarineSolute carrier family 22 member 2transporter
TubocurarineNeuronal acetylcholine receptor subunit alpha-7target
TubocurarineCholinesteraseenzyme
MetocurineNeuronal acetylcholine receptor subunit alpha-2target
MetocurineMuscarinic acetylcholine receptor M2target
BerberineHTH-type transcriptional regulator QacRtarget
BerberineBaculoviral IAP repeat-containing protein 5target
DrotaverinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DrotaverineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
TetrahydropalmatineDopamine D1 receptortarget
TetrahydropalmatineDopamine D2 receptortarget
TetrahydropalmatineCytochrome P450 3A4enzyme