Factor Xa Inhibitors

Name
Factor Xa Inhibitors
Accession Number
DBCAT001775
Description

Endogenous factors and drugs that inhibit or block the activity of FACTOR XA.

ATC Classification
Drugs
DrugDrug Description
RivaroxabanA factor Xa inhibitor used to treat deep vein thrombosis (DVT) and pulmonary embolism (PE). May also be used as thrombosis prophylaxis in specific situations.
ApixabanAn anticoagulant used for the prophylaxis of stroke and systemic embolism in nonvalvular atrial fibrillation, and deep vein thrombosis(DVT) leading to pulmonary embolism(PE), including in patients after a hip or knee replacement surgery.
EdoxabanA novel oral anticoagulant used for reducing the risk of stroke and systemic embolism (SE) in patients with nonvalvular atrial fibrillation (NVAF).
FondaparinuxAn anticoagulant used to prevent venous thromboembolism, to treat deep vein thrombosis, and to improve survival following myocardial infarction.
IdraparinuxInvestigated for use/treatment in thrombosis, venous thromboembolism, strokes, heart disease, and atrial fibrillation.
OtamixabanInvestigated for use/treatment in thrombosis.
LetaxabanLetaxaban has been used in trials studying the treatment and prevention of Venous Thromboembolism and Acute Coronary Syndrome.
DarexabanDarexaban has been used in trials studying the prevention and basic science of Japanese, Caucasian, Thromboembolism, Pharmacodynamics, and Pharmacokinetics, among others.
BetrixabanA Factor Xa inhibitor used for prophylaxis of venous thromboembolism in hospitalized patients.
Antithrombin AlfaA recombinant antithrombin used to treat peri-operative and peripartum thromboembolic events in hereditary antithrombin deficiency.
GW-813893Not Available
Drugs & Drug Targets
DrugTargetType
RivaroxabanCoagulation factor Xtarget
RivaroxabanCytochrome P450 3A4enzyme
RivaroxabanCytochrome P450 2J2enzyme
RivaroxabanP-glycoprotein 1transporter
RivaroxabanCytochrome P450 3A5enzyme
RivaroxabanATP-binding cassette sub-family G member 2transporter
ApixabanCoagulation factor Xtarget
ApixabanCytochrome P450 3A4enzyme
ApixabanCytochrome P450 1A2enzyme
ApixabanCytochrome P450 2C8enzyme
ApixabanCytochrome P450 2C9enzyme
ApixabanCytochrome P450 2C19enzyme
ApixabanCytochrome P450 2J2enzyme
ApixabanP-glycoprotein 1transporter
ApixabanATP-binding cassette sub-family G member 2transporter
ApixabanCytochrome P450 3A5enzyme
EdoxabanCoagulation factor Xtarget
EdoxabanP-glycoprotein 1transporter
FondaparinuxAntithrombin-IIItarget
FondaparinuxCoagulation factor Xtarget
IdraparinuxCoagulation factor Xtarget
OtamixabanCoagulation factor Xtarget
BetrixabanP-glycoprotein 1transporter
BetrixabanCoagulation factor Xtarget
BetrixabanPotassium voltage-gated channel subfamily H member 2transporter
BetrixabanProthrombinenzyme
Antithrombin AlfaProthrombintarget
Antithrombin AlfaCoagulation factor Xtarget
GW-813893Prothrombintarget
GW-813893Coagulation factor Xtarget