Letaxaban

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Letaxaban
Accession Number
DB11984
Type
Small Molecule
Groups
Investigational
Description

Letaxaban has been used in trials studying the treatment and prevention of Venous Thromboembolism and Acute Coronary Syndrome.

Structure
Thumb
Synonyms
Not Available
External IDs
TAK 442 / TAK-442
Categories
UNII
Y3WB03966W
CAS number
870262-90-1
Weight
Average: 479.977
Monoisotopic: 479.128169354
Chemical Formula
C22H26ClN3O5S
InChI Key
GEHAEMCVKDPMKO-HXUWFJFHSA-N
InChI
InChI=1S/C22H26ClN3O5S/c23-17-4-2-16-13-19(5-3-15(16)12-17)32(30,31)14-20(27)21(28)25-10-6-18(7-11-25)26-9-1-8-24-22(26)29/h2-5,12-13,18,20,27H,1,6-11,14H2,(H,24,29)/t20-/m1/s1
IUPAC Name
(2S)-3-[(6-chloronaphthalen-2-yl)sulfonyl]-2-hydroxy-1-[4-(2-hydroxy-1,4,5,6-tetrahydropyrimidin-1-yl)piperidin-1-yl]propan-1-one
SMILES
[H][C@@](O)(CS(=O)(=O)C1=CC2=CC=C(Cl)C=C2C=C1)C(=O)N1CCC(CC1)N1CCCN=C1O

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
(4R)-limonene(4R)-limonene may increase the anticoagulant activities of Letaxaban.Investigational
AbacavirThe serum concentration of Abacavir can be decreased when it is combined with Letaxaban.Approved, Investigational
AbciximabAbciximab may increase the anticoagulant activities of Letaxaban.Approved
AceclofenacAceclofenac may increase the anticoagulant activities of Letaxaban.Approved, Investigational
AcemetacinThe risk or severity of bleeding can be increased when Letaxaban is combined with Acemetacin.Approved, Experimental, Investigational
AcenocoumarolAcenocoumarol may increase the anticoagulant activities of Letaxaban.Approved, Investigational
Acetylsalicylic acidAcetylsalicylic acid may increase the anticoagulant activities of Letaxaban.Approved, Vet Approved
AdapaleneAdapalene may increase the anticoagulant activities of Letaxaban.Approved
AlclofenacAlclofenac may increase the anticoagulant activities of Letaxaban.Approved, Withdrawn
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Letaxaban.Approved, Investigational
AllylestrenolThe therapeutic efficacy of Letaxaban can be decreased when used in combination with Allylestrenol.Approved
AlminoprofenAlminoprofen may increase the anticoagulant activities of Letaxaban.Experimental
AloxiprinAloxiprin may increase the anticoagulant activities of Letaxaban.Experimental
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Letaxaban.Approved, Illicit, Investigational
AlprostadilAlprostadil may increase the anticoagulant activities of Letaxaban.Approved, Investigational
AlteplaseAlteplase may increase the anticoagulant activities of Letaxaban.Approved
AltrenogestThe therapeutic efficacy of Letaxaban can be decreased when used in combination with Altrenogest.Vet Approved
Ambroxol acefyllinateThe serum concentration of Ambroxol acefyllinate can be decreased when it is combined with Letaxaban.Experimental, Investigational
AmineptineThe serum concentration of Amineptine can be increased when it is combined with Letaxaban.Illicit, Withdrawn
AminophyllineThe serum concentration of Aminophylline can be decreased when it is combined with Letaxaban.Approved
Aminosalicylic AcidAminosalicylic Acid may increase the anticoagulant activities of Letaxaban.Approved
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Letaxaban.Approved
AmitriptylinoxideThe serum concentration of Amitriptylinoxide can be increased when it is combined with Letaxaban.Approved, Investigational
AmoxapineThe serum concentration of Amoxapine can be increased when it is combined with Letaxaban.Approved
AnagrelideAnagrelide may increase the anticoagulant activities of Letaxaban.Approved
AncrodAncrod may increase the anticoagulant activities of Letaxaban.Approved, Investigational
AndrographolideAndrographolide may increase the anticoagulant activities of Letaxaban.Investigational
AnisodamineAnisodamine may increase the anticoagulant activities of Letaxaban.Investigational
AnistreplaseAnistreplase may increase the anticoagulant activities of Letaxaban.Approved
AntipyrineAntipyrine may increase the anticoagulant activities of Letaxaban.Approved, Investigational
Antithrombin III humanAntithrombin III human may increase the anticoagulant activities of Letaxaban.Approved
ApixabanApixaban may increase the anticoagulant activities of Letaxaban.Approved
ApocyninApocynin may increase the anticoagulant activities of Letaxaban.Investigational
ApremilastApremilast may increase the anticoagulant activities of Letaxaban.Approved, Investigational
ArdeparinArdeparin may increase the anticoagulant activities of Letaxaban.Approved, Investigational, Withdrawn
ArgatrobanArgatroban may increase the anticoagulant activities of Letaxaban.Approved, Investigational
AstaxanthinAstaxanthin may increase the anticoagulant activities of Letaxaban.Investigational
AzapropazoneAzapropazone may increase the anticoagulant activities of Letaxaban.Withdrawn
AzelastineAzelastine may increase the anticoagulant activities of Letaxaban.Approved
Azficel-TThe risk or severity of adverse effects can be increased when Letaxaban is combined with Azficel-T.Approved, Investigational
BalsalazideBalsalazide may increase the anticoagulant activities of Letaxaban.Approved, Investigational
BatroxobinBatroxobin may increase the anticoagulant activities of Letaxaban.Experimental
BazedoxifeneBazedoxifene may decrease the anticoagulant activities of Letaxaban.Approved, Investigational
BecaplerminBecaplermin may increase the anticoagulant activities of Letaxaban.Approved, Investigational
BemiparinBemiparin may increase the anticoagulant activities of Letaxaban.Approved, Investigational
BendazacBendazac may increase the anticoagulant activities of Letaxaban.Experimental
BenorilateBenorilate may increase the anticoagulant activities of Letaxaban.Experimental
BenoxaprofenBenoxaprofen may increase the anticoagulant activities of Letaxaban.Withdrawn
BenzydamineBenzydamine may increase the anticoagulant activities of Letaxaban.Approved
BeraprostBeraprost may increase the anticoagulant activities of Letaxaban.Investigational
BevoniumBevonium may increase the anticoagulant activities of Letaxaban.Experimental
BivalirudinBivalirudin may increase the anticoagulant activities of Letaxaban.Approved, Investigational
BoceprevirThe serum concentration of Letaxaban can be decreased when it is combined with Boceprevir.Approved, Withdrawn
BrinaseBrinase may increase the anticoagulant activities of Letaxaban.Experimental
BromfenacBromfenac may increase the anticoagulant activities of Letaxaban.Approved
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Letaxaban.Approved, Investigational
BucillamineBucillamine may increase the anticoagulant activities of Letaxaban.Investigational
BufexamacBufexamac may increase the anticoagulant activities of Letaxaban.Approved, Experimental
BuflomedilBuflomedil may increase the anticoagulant activities of Letaxaban.Experimental
BumadizoneBumadizone may increase the anticoagulant activities of Letaxaban.Experimental
ButriptylineThe serum concentration of Butriptyline can be increased when it is combined with Letaxaban.Approved
ButylphthalideButylphthalide may increase the anticoagulant activities of Letaxaban.Investigational
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Letaxaban.Approved
CangrelorCangrelor may increase the anticoagulant activities of Letaxaban.Approved
CaplacizumabCaplacizumab may increase the anticoagulant activities of Letaxaban.Investigational
Carbaspirin calciumCarbaspirin calcium may increase the anticoagulant activities of Letaxaban.Experimental, Investigational
CarprofenCarprofen may increase the anticoagulant activities of Letaxaban.Approved, Vet Approved, Withdrawn
CastanospermineCastanospermine may increase the anticoagulant activities of Letaxaban.Experimental
CelecoxibCelecoxib may increase the anticoagulant activities of Letaxaban.Approved, Investigational
CertoparinCertoparin may increase the anticoagulant activities of Letaxaban.Approved, Investigational
ChlormadinoneThe therapeutic efficacy of Letaxaban can be decreased when used in combination with Chlormadinone.Experimental
ChloroquineChloroquine may increase the anticoagulant activities of Letaxaban.Approved, Investigational, Vet Approved
ChlorotrianiseneChlorotrianisene may decrease the anticoagulant activities of Letaxaban.Investigational, Withdrawn
Choline magnesium trisalicylateCholine magnesium trisalicylate may increase the anticoagulant activities of Letaxaban.Approved
CilostazolCilostazol may increase the anticoagulant activities of Letaxaban.Approved, Investigational
Citric AcidCitric Acid may increase the anticoagulant activities of Letaxaban.Approved, Nutraceutical, Vet Approved
ClarithromycinThe therapeutic efficacy of Clarithromycin can be decreased when used in combination with Letaxaban.Approved
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Letaxaban.Approved, Investigational, Vet Approved
ClonixinClonixin may increase the anticoagulant activities of Letaxaban.Approved
ClopidogrelClopidogrel may increase the anticoagulant activities of Letaxaban.Approved
CloricromenCloricromen may increase the anticoagulant activities of Letaxaban.Experimental
ClorindioneClorindione may increase the anticoagulant activities of Letaxaban.Experimental
Collagenase clostridium histolyticumThe risk or severity of adverse effects can be increased when Letaxaban is combined with Collagenase clostridium histolyticum.Approved, Investigational
Conjugated estrogensConjugated estrogens may decrease the anticoagulant activities of Letaxaban.Approved
CurcuminCurcumin may increase the anticoagulant activities of Letaxaban.Approved, Investigational
CyclophosphamideThe risk or severity of adverse effects can be increased when Letaxaban is combined with Cyclophosphamide.Approved, Investigational
Dabigatran etexilateDabigatran etexilate may increase the anticoagulant activities of Letaxaban.Approved
DaidzeinDaidzein may decrease the anticoagulant activities of Letaxaban.Experimental
DalteparinDalteparin may increase the anticoagulant activities of Letaxaban.Approved
DanaparoidDanaparoid may increase the anticoagulant activities of Letaxaban.Approved, Withdrawn
DarexabanLetaxaban may increase the anticoagulant activities of Darexaban.Investigational
DasatinibDasatinib may increase the anticoagulant activities of Letaxaban.Approved, Investigational
DeferasiroxThe risk or severity of adverse effects can be increased when Letaxaban is combined with Deferasirox.Approved, Investigational
DefibrotideDefibrotide may increase the anticoagulant activities of Letaxaban.Approved, Investigational
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Letaxaban.Approved
DemegestoneThe therapeutic efficacy of Letaxaban can be decreased when used in combination with Demegestone.Approved
Deoxycholic AcidThe risk or severity of adverse effects can be increased when Letaxaban is combined with Deoxycholic Acid.Approved
DersalazineDersalazine may increase the anticoagulant activities of Letaxaban.Investigational
DesipramineThe serum concentration of Desipramine can be increased when it is combined with Letaxaban.Approved, Investigational
DesirudinDesirudin may increase the anticoagulant activities of Letaxaban.Approved
DesmoteplaseDesmoteplase may increase the anticoagulant activities of Letaxaban.Investigational
DesogestrelThe therapeutic efficacy of Letaxaban can be decreased when used in combination with Desogestrel.Approved
DesvenlafaxineDesvenlafaxine may increase the antiplatelet activities of Letaxaban.Approved, Investigational
DextranDextran may increase the anticoagulant activities of Letaxaban.Approved, Investigational, Vet Approved
DibenzepinThe serum concentration of Dibenzepin can be increased when it is combined with Letaxaban.Experimental
DiclofenacDiclofenac may increase the anticoagulant activities of Letaxaban.Approved, Vet Approved
DicoumarolDicoumarol may increase the anticoagulant activities of Letaxaban.Approved
DienestrolDienestrol may decrease the anticoagulant activities of Letaxaban.Approved, Investigational
DienogestThe therapeutic efficacy of Letaxaban can be decreased when used in combination with Dienogest.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Letaxaban.Approved, Investigational
DifenpiramideDifenpiramide may increase the anticoagulant activities of Letaxaban.Experimental
DiflunisalDiflunisal may increase the anticoagulant activities of Letaxaban.Approved, Investigational
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Letaxaban.Approved
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Letaxaban.Approved, Investigational
DiltiazemThe metabolism of Diltiazem can be decreased when combined with Letaxaban.Approved, Investigational
DimetacrineThe serum concentration of Dimetacrine can be increased when it is combined with Letaxaban.Approved, Withdrawn
DiphenadioneDiphenadione may increase the anticoagulant activities of Letaxaban.Experimental
DipyridamoleDipyridamole may increase the anticoagulant activities of Letaxaban.Approved
DitazoleDitazole may increase the anticoagulant activities of Letaxaban.Approved, Withdrawn
DosulepinThe serum concentration of Dosulepin can be increased when it is combined with Letaxaban.Approved
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Letaxaban.Approved, Investigational
DrospirenoneThe therapeutic efficacy of Letaxaban can be decreased when used in combination with Drospirenone.Approved
Drotrecogin alfaDrotrecogin alfa may increase the anticoagulant activities of Letaxaban.Approved, Investigational, Withdrawn
DroxicamDroxicam may increase the anticoagulant activities of Letaxaban.Withdrawn
DuvelisibDuvelisib may increase the anticoagulant activities of Letaxaban.Investigational
DydrogesteroneThe therapeutic efficacy of Letaxaban can be decreased when used in combination with Dydrogesterone.Approved, Investigational, Withdrawn
DyphyllineThe serum concentration of Dyphylline can be decreased when it is combined with Letaxaban.Approved
E-6201E-6201 may increase the anticoagulant activities of Letaxaban.Investigational
Edetic AcidEdetic Acid may increase the anticoagulant activities of Letaxaban.Approved, Vet Approved
EdoxabanEdoxaban may increase the anticoagulant activities of Letaxaban.Approved
EnfuvirtideThe serum concentration of Enfuvirtide can be increased when it is combined with Letaxaban.Approved, Investigational
EnoxaparinEnoxaparin may increase the anticoagulant activities of Letaxaban.Approved
EpimestrolEpimestrol may decrease the anticoagulant activities of Letaxaban.Experimental
EpinastineEpinastine may increase the anticoagulant activities of Letaxaban.Approved, Investigational
EpirizoleEpirizole may increase the anticoagulant activities of Letaxaban.Approved
EplivanserinEplivanserin may increase the anticoagulant activities of Letaxaban.Investigational
eplivanserineeplivanserine may increase the anticoagulant activities of Letaxaban.Investigational
EpoprostenolEpoprostenol may increase the anticoagulant activities of Letaxaban.Approved
EptifibatideEptifibatide may increase the anticoagulant activities of Letaxaban.Approved, Investigational
EquolEquol may decrease the anticoagulant activities of Letaxaban.Investigational
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Letaxaban.Approved
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Letaxaban.Approved
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Letaxaban.Approved
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Letaxaban.Approved, Investigational, Vet Approved
Estradiol acetateEstradiol acetate may decrease the anticoagulant activities of Letaxaban.Approved, Investigational, Vet Approved
Estradiol cypionateEstradiol cypionate may decrease the anticoagulant activities of Letaxaban.Approved, Investigational, Vet Approved
Estradiol valerateEstradiol valerate may decrease the anticoagulant activities of Letaxaban.Approved, Investigational, Vet Approved
EstriolEstriol may decrease the anticoagulant activities of Letaxaban.Approved, Investigational, Vet Approved
Estrogens, esterifiedEstrogens, esterified may decrease the anticoagulant activities of Letaxaban.Approved
EstroneEstrone may decrease the anticoagulant activities of Letaxaban.Approved
EtanerceptEtanercept may increase the anticoagulant activities of Letaxaban.Approved, Investigational
EthenzamideEthenzamide may increase the anticoagulant activities of Letaxaban.Experimental
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Letaxaban.Approved
Ethyl biscoumacetateEthyl biscoumacetate may increase the anticoagulant activities of Letaxaban.Withdrawn
EthynodiolThe therapeutic efficacy of Letaxaban can be decreased when used in combination with Ethynodiol.Experimental
EtodolacEtodolac may increase the anticoagulant activities of Letaxaban.Approved, Investigational, Vet Approved
EtofenamateEtofenamate may increase the anticoagulant activities of Letaxaban.Approved, Investigational
EtonogestrelThe therapeutic efficacy of Letaxaban can be decreased when used in combination with Etonogestrel.Approved, Investigational
EtoricoxibEtoricoxib may increase the anticoagulant activities of Letaxaban.Approved, Investigational
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Letaxaban.Approved
Evening primrose oilEvening primrose oil may increase the anticoagulant activities of Letaxaban.Investigational, Nutraceutical
ExisulindExisulind may increase the anticoagulant activities of Letaxaban.Investigational
FelbinacFelbinac may increase the anticoagulant activities of Letaxaban.Experimental
FenbufenFenbufen may increase the anticoagulant activities of Letaxaban.Approved
FenoprofenFenoprofen may increase the anticoagulant activities of Letaxaban.Approved
FentiazacFentiazac may increase the anticoagulant activities of Letaxaban.Experimental
FeprazoneFeprazone may increase the anticoagulant activities of Letaxaban.Experimental
Ferulic acidFerulic acid may increase the anticoagulant activities of Letaxaban.Experimental
FibrinolysinFibrinolysin may increase the anticoagulant activities of Letaxaban.Investigational
FloctafenineFloctafenine may increase the anticoagulant activities of Letaxaban.Approved, Withdrawn
FluindioneLetaxaban may increase the anticoagulant activities of Fluindione.Approved, Investigational
FlunixinFlunixin may increase the anticoagulant activities of Letaxaban.Vet Approved
FlunoxaprofenFlunoxaprofen may increase the anticoagulant activities of Letaxaban.Experimental
FluoxetineFluoxetine may increase the antiplatelet activities of Letaxaban.Approved, Vet Approved
FlurbiprofenFlurbiprofen may increase the anticoagulant activities of Letaxaban.Approved, Investigational
FondaparinuxFondaparinux sodium may increase the anticoagulant activities of Letaxaban.Approved, Investigational
GabexateLetaxaban may increase the anticoagulant activities of Gabexate.Investigational
GarlicThe serum concentration of Letaxaban can be decreased when it is combined with Garlic.Approved, Nutraceutical
GenisteinGenistein may decrease the anticoagulant activities of Letaxaban.Investigational
GestodeneThe therapeutic efficacy of Letaxaban can be decreased when used in combination with Gestodene.Approved, Investigational
GestonoroneThe therapeutic efficacy of Letaxaban can be decreased when used in combination with Gestonorone.Experimental
GestrinoneThe therapeutic efficacy of Letaxaban can be decreased when used in combination with Gestrinone.Approved
GuacetisalGuacetisal may increase the anticoagulant activities of Letaxaban.Experimental
HeminHemin may increase the anticoagulant activities of Letaxaban.Approved, Investigational
Hemoglobin crosfumarilHemoglobin crosfumaril may increase the anticoagulant activities of Letaxaban.Experimental
HeparinHeparin may increase the anticoagulant activities of Letaxaban.Approved, Investigational
HexestrolHexestrol may decrease the anticoagulant activities of Letaxaban.Withdrawn
HigenamineHigenamine may increase the anticoagulant activities of Letaxaban.Investigational
Hydroxyprogesterone caproateThe therapeutic efficacy of Letaxaban can be decreased when used in combination with Hydroxyprogesterone caproate.Approved, Investigational
HydroxytyrosolHydroxytyrosol may increase the anticoagulant activities of Letaxaban.Investigational
Ibritumomab tiuxetanThe risk or severity of adverse effects can be increased when Letaxaban is combined with Ibritumomab tiuxetan.Approved, Investigational
IbrutinibThe risk or severity of adverse effects can be increased when Ibrutinib is combined with Letaxaban.Approved
IbudilastIbudilast may increase the anticoagulant activities of Letaxaban.Approved, Investigational
IbuprofenThe risk or severity of bleeding and hemorrhage can be increased when Ibuprofen is combined with Letaxaban.Approved
IbuproxamIbuproxam may increase the anticoagulant activities of Letaxaban.Withdrawn
IcatibantIcatibant may increase the anticoagulant activities of Letaxaban.Approved, Investigational
Icosapent ethylIcosapent ethyl may increase the anticoagulant activities of Letaxaban.Approved, Investigational, Nutraceutical
IdraparinuxIdraparinux may increase the anticoagulant activities of Letaxaban.Investigational
IfenprodilIfenprodil may increase the anticoagulant activities of Letaxaban.Approved, Investigational, Withdrawn
IfetrobanIfetroban may increase the anticoagulant activities of Letaxaban.Investigational
IloprostIloprost may increase the anticoagulant activities of Letaxaban.Approved, Investigational
Imidazole salicylateImidazole salicylate may increase the anticoagulant activities of Letaxaban.Experimental
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Letaxaban.Approved
IndobufenIndobufen may increase the anticoagulant activities of Letaxaban.Investigational
IndomethacinIndomethacin may increase the anticoagulant activities of Letaxaban.Approved, Investigational
IndoprofenIndoprofen may increase the anticoagulant activities of Letaxaban.Withdrawn
IprindoleThe serum concentration of Iprindole can be increased when it is combined with Letaxaban.Experimental
IsoxicamIsoxicam may increase the anticoagulant activities of Letaxaban.Withdrawn
KebuzoneKebuzone may increase the anticoagulant activities of Letaxaban.Experimental
KetanserinKetanserin may increase the anticoagulant activities of Letaxaban.Investigational
KetoprofenKetoprofen may increase the anticoagulant activities of Letaxaban.Approved, Vet Approved
KetorolacKetorolac may increase the anticoagulant activities of Letaxaban.Approved
LeflunomideLeflunomide may increase the anticoagulant activities of Letaxaban.Approved, Investigational
LepirudinLetaxaban may increase the anticoagulant activities of Lepirudin.Approved
LevonorgestrelThe therapeutic efficacy of Letaxaban can be decreased when used in combination with Levonorgestrel.Approved, Investigational
LimaprostThe risk or severity of adverse effects can be increased when Limaprost is combined with Letaxaban.Approved, Investigational
LinsidomineLinsidomine may increase the anticoagulant activities of Letaxaban.Experimental
LisofyllineLisofylline may increase the anticoagulant activities of Letaxaban.Investigational
LofepramineThe serum concentration of Lofepramine can be increased when it is combined with Letaxaban.Experimental
LonazolacLonazolac may increase the anticoagulant activities of Letaxaban.Experimental
LornoxicamLornoxicam may increase the anticoagulant activities of Letaxaban.Approved, Investigational
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Letaxaban.Approved, Investigational
LoxoprofenLoxoprofen may increase the anticoagulant activities of Letaxaban.Approved, Investigational
LumiracoxibLumiracoxib may increase the anticoagulant activities of Letaxaban.Approved, Investigational
LynestrenolThe therapeutic efficacy of Letaxaban can be decreased when used in combination with Lynestrenol.Approved, Investigational
Magnesium salicylateMagnesium salicylate may increase the anticoagulant activities of Letaxaban.Approved
MasoprocolMasoprocol may increase the anticoagulant activities of Letaxaban.Approved, Investigational
Meclofenamic acidMeclofenamic acid may increase the anticoagulant activities of Letaxaban.Approved, Vet Approved
MedrogestoneThe therapeutic efficacy of Letaxaban can be decreased when used in combination with Medrogestone.Approved
Medroxyprogesterone acetateThe therapeutic efficacy of Letaxaban can be decreased when used in combination with Medroxyprogesterone acetate.Approved, Investigational
Mefenamic acidMefenamic acid may increase the anticoagulant activities of Letaxaban.Approved
Megestrol acetateThe therapeutic efficacy of Letaxaban can be decreased when used in combination with Megestrol acetate.Approved, Investigational, Vet Approved
MelagatranLetaxaban may increase the anticoagulant activities of Melagatran.Experimental
MelitracenThe serum concentration of Melitracen can be increased when it is combined with Letaxaban.Experimental, Investigational
MeloxicamMeloxicam may increase the anticoagulant activities of Letaxaban.Approved, Vet Approved
MesalazineMesalazine may increase the anticoagulant activities of Letaxaban.Approved
MestranolThe serum concentration of Mestranol can be decreased when it is combined with Letaxaban.Approved
MetamizoleMetamizole may increase the anticoagulant activities of Letaxaban.Approved, Investigational, Withdrawn
MethallenestrilMethallenestril may decrease the anticoagulant activities of Letaxaban.Experimental
Methyl salicylateMethyl salicylate may increase the anticoagulant activities of Letaxaban.Approved, Vet Approved
MethylergometrineThe serum concentration of Methylergometrine can be increased when it is combined with Letaxaban.Approved
MethylestrenoloneThe therapeutic efficacy of Letaxaban can be decreased when used in combination with Methylestrenolone.Experimental
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Letaxaban.Approved, Illicit
MilrinoneMilrinone may increase the anticoagulant activities of Letaxaban.Approved
MizoribineMizoribine may increase the anticoagulant activities of Letaxaban.Investigational
MofebutazoneMofebutazone may increase the anticoagulant activities of Letaxaban.Experimental
MoxestrolMoxestrol may decrease the anticoagulant activities of Letaxaban.Experimental
Mycophenolate mofetilMycophenolate mofetil may increase the anticoagulant activities of Letaxaban.Approved, Investigational
Mycophenolic acidMycophenolic acid may increase the anticoagulant activities of Letaxaban.Approved
NabumetoneNabumetone may increase the anticoagulant activities of Letaxaban.Approved
NadroparinNadroparin may increase the anticoagulant activities of Letaxaban.Approved, Investigational
NafamostatNafamostat may increase the anticoagulant activities of Letaxaban.Approved, Investigational
NaftifineNaftifine may increase the anticoagulant activities of Letaxaban.Approved
NaftopidilNaftopidil may increase the anticoagulant activities of Letaxaban.Investigational
NaproxenNaproxen may increase the anticoagulant activities of Letaxaban.Approved, Vet Approved
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Letaxaban.Approved, Withdrawn
NepafenacNepafenac may increase the anticoagulant activities of Letaxaban.Approved, Investigational
NifenazoneNifenazone may increase the anticoagulant activities of Letaxaban.Experimental
Niflumic AcidNiflumic Acid may increase the anticoagulant activities of Letaxaban.Approved
NimesulideNimesulide may increase the anticoagulant activities of Letaxaban.Approved, Investigational, Withdrawn
NintedanibThe risk or severity of adverse effects can be increased when Letaxaban is combined with Nintedanib.Approved
NitroaspirinNitroaspirin may increase the anticoagulant activities of Letaxaban.Investigational
NomegestrolThe therapeutic efficacy of Letaxaban can be decreased when used in combination with Nomegestrol.Approved
NorethisteroneThe therapeutic efficacy of Letaxaban can be decreased when used in combination with Norethisterone.Approved
NorgestrienoneThe therapeutic efficacy of Letaxaban can be decreased when used in combination with Norgestrienone.Experimental
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Letaxaban.Approved
ObinutuzumabThe risk or severity of adverse effects can be increased when Letaxaban is combined with Obinutuzumab.Approved, Investigational
OlopatadineOlopatadine may increase the anticoagulant activities of Letaxaban.Approved
OlsalazineOlsalazine may increase the anticoagulant activities of Letaxaban.Approved
Omacetaxine mepesuccinateThe risk or severity of bleeding can be increased when Letaxaban is combined with Omacetaxine mepesuccinate.Approved, Investigational
Omega-3 fatty acidsOmega-3 fatty acids may increase the anticoagulant activities of Letaxaban.Approved, Nutraceutical
Omega-3-carboxylic acidsThe therapeutic efficacy of Letaxaban can be increased when used in combination with Omega-3-carboxylic acids.Approved, Investigational
OpipramolThe serum concentration of Opipramol can be increased when it is combined with Letaxaban.Investigational
OrgoteinOrgotein may increase the anticoagulant activities of Letaxaban.Vet Approved
OtamixabanOtamixaban may increase the anticoagulant activities of Letaxaban.Investigational
OxaprozinOxaprozin may increase the anticoagulant activities of Letaxaban.Approved
OxyphenbutazoneOxyphenbutazone may increase the anticoagulant activities of Letaxaban.Approved, Withdrawn
OzagrelOzagrel may increase the anticoagulant activities of Letaxaban.Investigational
PalmidrolPalmidrol may increase the anticoagulant activities of Letaxaban.Experimental, Nutraceutical
ParecoxibParecoxib may increase the anticoagulant activities of Letaxaban.Approved
ParnaparinParnaparin may increase the anticoagulant activities of Letaxaban.Approved, Investigational
ParthenolideParthenolide may increase the anticoagulant activities of Letaxaban.Approved, Investigational
Pentaerythritol TetranitratePentaerythritol Tetranitrate may increase the anticoagulant activities of Letaxaban.Approved
Pentosan PolysulfatePentosan Polysulfate may increase the anticoagulant activities of Letaxaban.Approved
PentoxifyllinePentoxifylline may increase the anticoagulant activities of Letaxaban.Approved, Investigational
PethidineThe risk or severity of adverse effects can be increased when Letaxaban is combined with Pethidine.Approved
PhenindionePhenindione may increase the anticoagulant activities of Letaxaban.Approved, Investigational
PhenprocoumonPhenprocoumon may increase the anticoagulant activities of Letaxaban.Approved, Investigational
Phenyl aminosalicylatePhenyl aminosalicylate may increase the anticoagulant activities of Letaxaban.Approved
PhenylbutazonePhenylbutazone may increase the anticoagulant activities of Letaxaban.Approved, Vet Approved
PicotamidePicotamide may increase the anticoagulant activities of Letaxaban.Experimental
PimecrolimusPimecrolimus may increase the anticoagulant activities of Letaxaban.Approved, Investigational
PirfenidonePirfenidone may increase the anticoagulant activities of Letaxaban.Approved, Investigational
PiroxicamPiroxicam may increase the anticoagulant activities of Letaxaban.Approved, Investigational
PirprofenPirprofen may increase the anticoagulant activities of Letaxaban.Experimental
Polyestradiol phosphatePolyestradiol phosphate may decrease the anticoagulant activities of Letaxaban.Approved
Potassium CitrateLetaxaban may increase the anticoagulant activities of Potassium Citrate.Approved, Investigational, Vet Approved
PranoprofenPranoprofen may increase the anticoagulant activities of Letaxaban.Experimental, Investigational
PrasugrelPrasugrel may increase the anticoagulant activities of Letaxaban.Approved
ProgesteroneThe therapeutic efficacy of Letaxaban can be decreased when used in combination with Progesterone.Approved, Vet Approved
ProglumetacinProglumetacin may increase the anticoagulant activities of Letaxaban.Experimental
PromegestoneThe therapeutic efficacy of Letaxaban can be decreased when used in combination with Promegestone.Experimental
PromestrienePromestriene may decrease the anticoagulant activities of Letaxaban.Investigational
PropacetamolPropacetamol may increase the anticoagulant activities of Letaxaban.Approved, Investigational
PropyphenazonePropyphenazone may increase the anticoagulant activities of Letaxaban.Experimental
ProquazoneProquazone may increase the anticoagulant activities of Letaxaban.Experimental
Protein CProtein C may increase the anticoagulant activities of Letaxaban.Approved
Protein S humanLetaxaban may increase the anticoagulant activities of Protein S human.Approved
ProtocatechualdehydeProtocatechualdehyde may increase the anticoagulant activities of Letaxaban.Approved
ProtriptylineThe serum concentration of Protriptyline can be increased when it is combined with Letaxaban.Approved
PTC299PTC299 may increase the anticoagulant activities of Letaxaban.Investigational
QuinestrolQuinestrol may decrease the anticoagulant activities of Letaxaban.Approved
QuingestanolThe therapeutic efficacy of Letaxaban can be decreased when used in combination with Quingestanol.Experimental
RamatrobanRamatroban may increase the anticoagulant activities of Letaxaban.Investigational
RelcovaptanRelcovaptan may increase the anticoagulant activities of Letaxaban.Investigational
ResveratrolResveratrol may increase the anticoagulant activities of Letaxaban.Approved, Experimental, Investigational
ReteplaseReteplase may increase the anticoagulant activities of Letaxaban.Approved, Investigational
ReviparinReviparin may increase the anticoagulant activities of Letaxaban.Approved, Investigational
RidogrelRidogrel may increase the anticoagulant activities of Letaxaban.Approved
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Letaxaban.Approved
RivaroxabanLetaxaban may increase the anticoagulant activities of Rivaroxaban.Approved
RofecoxibRofecoxib may increase the anticoagulant activities of Letaxaban.Approved, Investigational, Withdrawn
RosiglitazoneRosiglitazone may increase the anticoagulant activities of Letaxaban.Approved, Investigational
SalicylamideSalicylamide may increase the anticoagulant activities of Letaxaban.Approved
Salicylic acidSalicylic acid may increase the anticoagulant activities of Letaxaban.Approved, Investigational, Vet Approved
SalsalateSalsalate may increase the anticoagulant activities of Letaxaban.Approved
SarpogrelateSarpogrelate may increase the anticoagulant activities of Letaxaban.Investigational
SecoisolariciresinolSecoisolariciresinol may decrease the anticoagulant activities of Letaxaban.Investigational
SelexipagSelexipag may increase the anticoagulant activities of Letaxaban.Approved
SemapimodSemapimod may increase the anticoagulant activities of Letaxaban.Investigational
SeratrodastSeratrodast may increase the anticoagulant activities of Letaxaban.Approved
SerrapeptaseSerrapeptase may increase the anticoagulant activities of Letaxaban.Investigational
SevofluraneSevoflurane may increase the anticoagulant activities of Letaxaban.Approved, Vet Approved
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Letaxaban.Approved, Investigational
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Letaxaban.Approved
Sodium CitrateLetaxaban may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
SRT501SRT501 may increase the anticoagulant activities of Letaxaban.Investigational
St. John's WortThe metabolism of Letaxaban can be increased when combined with St. John's Wort.Approved, Investigational, Nutraceutical
StreptokinaseStreptokinase may increase the anticoagulant activities of Letaxaban.Approved, Investigational
SugammadexSugammadex may increase the anticoagulant activities of Letaxaban.Approved
SulfasalazineSulfasalazine may increase the anticoagulant activities of Letaxaban.Approved
SulindacSulindac may increase the anticoagulant activities of Letaxaban.Approved, Investigational
SulodexideSulodexide may increase the anticoagulant activities of Letaxaban.Approved, Investigational
SuprofenSuprofen may increase the anticoagulant activities of Letaxaban.Approved, Withdrawn
SuxibuzoneSuxibuzone may increase the anticoagulant activities of Letaxaban.Experimental
Synthetic Conjugated Estrogens, ASynthetic Conjugated Estrogens, A may decrease the anticoagulant activities of Letaxaban.Approved
Synthetic Conjugated Estrogens, BSynthetic Conjugated Estrogens, B may decrease the anticoagulant activities of Letaxaban.Approved
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Letaxaban.Approved, Investigational
TarenflurbilTarenflurbil may increase the anticoagulant activities of Letaxaban.Investigational
TemsirolimusThe risk or severity of adverse effects can be increased when Letaxaban is combined with Temsirolimus.Approved
TenecteplaseTenecteplase may increase the anticoagulant activities of Letaxaban.Approved
TenidapTenidap may increase the anticoagulant activities of Letaxaban.Experimental
TenoxicamTenoxicam may increase the anticoagulant activities of Letaxaban.Approved
TepoxalinTepoxalin may increase the anticoagulant activities of Letaxaban.Vet Approved
TeriflunomideTeriflunomide may increase the anticoagulant activities of Letaxaban.Approved
TesmilifeneTesmilifene may increase the anticoagulant activities of Letaxaban.Investigational
Testosterone cypionateThe therapeutic efficacy of Letaxaban can be increased when used in combination with Testosterone cypionate.Approved
Testosterone enanthateThe therapeutic efficacy of Letaxaban can be increased when used in combination with Testosterone enanthate.Approved
Testosterone undecanoateThe therapeutic efficacy of Letaxaban can be increased when used in combination with Testosterone undecanoate.Approved, Investigational
TheophyllineThe serum concentration of Theophylline can be decreased when it is combined with Letaxaban.Approved
TianeptineThe serum concentration of Tianeptine can be increased when it is combined with Letaxaban.Approved, Investigational
Tiaprofenic acidTiaprofenic acid may increase the anticoagulant activities of Letaxaban.Approved
TiboloneTibolone may increase the anticoagulant activities of Letaxaban.Approved, Investigational
TicagrelorTicagrelor may increase the anticoagulant activities of Letaxaban.Approved
TiclopidineTiclopidine may increase the anticoagulant activities of Letaxaban.Approved
TinoridineTinoridine may increase the anticoagulant activities of Letaxaban.Investigational
TinzaparinTinzaparin may increase the anticoagulant activities of Letaxaban.Approved
TioclomarolTioclomarol may increase the anticoagulant activities of Letaxaban.Experimental
TipranavirThe serum concentration of Letaxaban can be decreased when it is combined with Tipranavir.Approved, Investigational
TirofibanTirofiban may increase the anticoagulant activities of Letaxaban.Approved
Tolfenamic AcidTolfenamic Acid may increase the anticoagulant activities of Letaxaban.Approved, Investigational
TolmetinTolmetin may increase the anticoagulant activities of Letaxaban.Approved
TositumomabThe risk or severity of adverse effects can be increased when Letaxaban is combined with Tositumomab.Approved, Investigational
TranilastTranilast may increase the anticoagulant activities of Letaxaban.Approved, Investigational
TrapidilTrapidil may increase the anticoagulant activities of Letaxaban.Approved
TreprostinilTreprostinil may increase the anticoagulant activities of Letaxaban.Approved, Investigational
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Letaxaban.Approved, Investigational
TribenosideTribenoside may increase the anticoagulant activities of Letaxaban.Experimental
TriflusalTriflusal may increase the anticoagulant activities of Letaxaban.Approved, Investigational
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Letaxaban.Approved
TriptolideTriptolide may increase the anticoagulant activities of Letaxaban.Investigational
Trolamine salicylateTrolamine salicylate may increase the anticoagulant activities of Letaxaban.Approved
TroxerutinLetaxaban may increase the anticoagulant activities of Troxerutin.Investigational
UrokinaseUrokinase may increase the anticoagulant activities of Letaxaban.Approved, Investigational, Withdrawn
ValdecoxibValdecoxib may increase the anticoagulant activities of Letaxaban.Approved, Investigational, Withdrawn
VenlafaxineVenlafaxine may increase the antiplatelet activities of Letaxaban.Approved
VerapamilThe metabolism of Verapamil can be decreased when combined with Letaxaban.Approved
Vitamin EVitamin E may increase the anticoagulant activities of Letaxaban.Approved, Nutraceutical, Vet Approved
VorapaxarThe risk or severity of adverse effects can be increased when Vorapaxar is combined with Letaxaban.Approved
WarfarinWarfarin may increase the anticoagulant activities of Letaxaban.Approved
XimelagatranXimelagatran may increase the anticoagulant activities of Letaxaban.Approved, Investigational, Withdrawn
ZaltoprofenZaltoprofen may increase the anticoagulant activities of Letaxaban.Approved, Investigational
ZeranolZeranol may decrease the anticoagulant activities of Letaxaban.Vet Approved
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Letaxaban.Approved
ZileutonZileuton may increase the anticoagulant activities of Letaxaban.Approved, Investigational, Withdrawn
ZomepiracZomepirac may increase the anticoagulant activities of Letaxaban.Withdrawn
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Compound
11641515
PubChem Substance
347828305
ChemSpider
9816256
BindingDB
50317098
ChEMBL
CHEMBL1095032
HET
443
PDB Entries
3kl6

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedPreventionVenous Thromboembolism (VTE)1
2CompletedTreatmentAcute Coronary Syndromes (ACS)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.102 mg/mLALOGPS
logP1.87ALOGPS
logP1.01ChemAxon
logS-3.7ALOGPS
pKa (Strongest Acidic)8.92ChemAxon
pKa (Strongest Basic)7.23ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area110.51 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity121.67 m3·mol-1ChemAxon
Polarizability46.71 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as chloronaphthalenes. These are aromatic heterocyclic compounds containing a naphthalene moiety substituted at one or more positions by a chlorine atom.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Naphthalenes
Sub Class
Chloronaphthalenes
Direct Parent
Chloronaphthalenes
Alternative Parents
N-acylpiperidines / Pyrimidones / Diazinanes / Aryl chlorides / Tertiary carboxylic acid amides / Sulfones / Ureas / Secondary alcohols / Azacyclic compounds / Organonitrogen compounds
show 4 more
Substituents
Chloronaphthalene / N-acyl-piperidine / Pyrimidone / Aryl chloride / Aryl halide / 1,3-diazinane / Piperidine / Pyrimidine / Tertiary carboxylic acid amide / Sulfonyl
show 19 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available

Drug created on October 20, 2016 15:08 / Updated on August 02, 2018 06:32