Darexaban

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Darexaban
Accession Number
DB12289
Type
Small Molecule
Groups
Investigational
Description

Darexaban has been used in trials studying the prevention and basic science of Japanese, Caucasian, Thromboembolism, Pharmacodynamics, and Pharmacokinetics, among others.

Structure
Thumb
Synonyms
Not Available
External IDs
YM-150 / YM150
Product Ingredients
IngredientUNIICASInChI Key
Darexaban Maleate03RTP2436R365462-24-4WHMPMUVISXATBH-BTJKTKAUSA-N
Categories
UNII
KF322K101S
CAS number
365462-23-3
Weight
Average: 474.561
Monoisotopic: 474.226705462
Chemical Formula
C27H30N4O4
InChI Key
IJNIQYINMSGIPS-UHFFFAOYSA-N
InChI
InChI=1S/C27H30N4O4/c1-30-15-4-16-31(18-17-30)21-11-7-19(8-12-21)27(34)29-25-23(5-3-6-24(25)32)28-26(33)20-9-13-22(35-2)14-10-20/h3,5-14,32H,4,15-18H2,1-2H3,(H,28,33)(H,29,34)
IUPAC Name
N-[2-hydroxy-6-(4-methoxybenzamido)phenyl]-4-(4-methyl-1,4-diazepan-1-yl)benzamide
SMILES
COC1=CC=C(C=C1)C(=O)NC1=C(NC(=O)C2=CC=C(C=C2)N2CCCN(C)CC2)C(O)=CC=C1

Pharmacology

Indication
Not Available
Structured Indications
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
(4R)-limonene(4R)-limonene may increase the anticoagulant activities of Darexaban.Investigational
AbacavirThe serum concentration of Abacavir can be decreased when it is combined with Darexaban.Approved, Investigational
AbciximabAbciximab may increase the anticoagulant activities of Darexaban.Approved
AceclofenacAceclofenac may increase the anticoagulant activities of Darexaban.Approved, Investigational
AcemetacinThe risk or severity of bleeding can be increased when Darexaban is combined with Acemetacin.Approved, Experimental, Investigational
AcenocoumarolAcenocoumarol may increase the anticoagulant activities of Darexaban.Approved, Investigational
Acetylsalicylic acidAcetylsalicylic acid may increase the anticoagulant activities of Darexaban.Approved, Vet Approved
AdapaleneAdapalene may increase the anticoagulant activities of Darexaban.Approved
AlclofenacAlclofenac may increase the anticoagulant activities of Darexaban.Approved, Withdrawn
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Darexaban.Approved, Investigational
AllylestrenolThe therapeutic efficacy of Darexaban can be decreased when used in combination with Allylestrenol.Approved
AlminoprofenAlminoprofen may increase the anticoagulant activities of Darexaban.Experimental
AloxiprinAloxiprin may increase the anticoagulant activities of Darexaban.Experimental
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Darexaban.Approved, Illicit, Investigational
AlprostadilAlprostadil may increase the anticoagulant activities of Darexaban.Approved, Investigational
AlteplaseAlteplase may increase the anticoagulant activities of Darexaban.Approved
AltrenogestThe therapeutic efficacy of Darexaban can be decreased when used in combination with Altrenogest.Vet Approved
Ambroxol acefyllinateThe serum concentration of Ambroxol acefyllinate can be decreased when it is combined with Darexaban.Experimental, Investigational
AmineptineThe serum concentration of Amineptine can be increased when it is combined with Darexaban.Illicit, Withdrawn
AminophyllineThe serum concentration of Aminophylline can be decreased when it is combined with Darexaban.Approved
Aminosalicylic AcidAminosalicylic Acid may increase the anticoagulant activities of Darexaban.Approved
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Darexaban.Approved
AmitriptylinoxideThe serum concentration of Amitriptylinoxide can be increased when it is combined with Darexaban.Approved, Investigational
AmoxapineThe serum concentration of Amoxapine can be increased when it is combined with Darexaban.Approved
AnagrelideAnagrelide may increase the anticoagulant activities of Darexaban.Approved
AncrodAncrod may increase the anticoagulant activities of Darexaban.Approved, Investigational
AndrographolideAndrographolide may increase the anticoagulant activities of Darexaban.Investigational
AnisodamineAnisodamine may increase the anticoagulant activities of Darexaban.Investigational
AnistreplaseAnistreplase may increase the anticoagulant activities of Darexaban.Approved
AntipyrineAntipyrine may increase the anticoagulant activities of Darexaban.Approved, Investigational
Antithrombin III humanAntithrombin III human may increase the anticoagulant activities of Darexaban.Approved
ApixabanApixaban may increase the anticoagulant activities of Darexaban.Approved
ApocyninApocynin may increase the anticoagulant activities of Darexaban.Investigational
ApremilastApremilast may increase the anticoagulant activities of Darexaban.Approved, Investigational
ArdeparinArdeparin may increase the anticoagulant activities of Darexaban.Approved, Investigational, Withdrawn
ArgatrobanArgatroban may increase the anticoagulant activities of Darexaban.Approved, Investigational
AstaxanthinAstaxanthin may increase the anticoagulant activities of Darexaban.Investigational
AzapropazoneAzapropazone may increase the anticoagulant activities of Darexaban.Withdrawn
AzelastineAzelastine may increase the anticoagulant activities of Darexaban.Approved
Azficel-TThe risk or severity of adverse effects can be increased when Darexaban is combined with Azficel-T.Approved, Investigational
BalsalazideBalsalazide may increase the anticoagulant activities of Darexaban.Approved, Investigational
BatroxobinBatroxobin may increase the anticoagulant activities of Darexaban.Experimental
BecaplerminBecaplermin may increase the anticoagulant activities of Darexaban.Approved, Investigational
BemiparinBemiparin may increase the anticoagulant activities of Darexaban.Approved, Investigational
BendazacBendazac may increase the anticoagulant activities of Darexaban.Experimental
BenorilateBenorilate may increase the anticoagulant activities of Darexaban.Experimental
BenoxaprofenBenoxaprofen may increase the anticoagulant activities of Darexaban.Withdrawn
BenzydamineBenzydamine may increase the anticoagulant activities of Darexaban.Approved
BeraprostBeraprost may increase the anticoagulant activities of Darexaban.Investigational
BevoniumBevonium may increase the anticoagulant activities of Darexaban.Experimental
BivalirudinBivalirudin may increase the anticoagulant activities of Darexaban.Approved, Investigational
BoceprevirThe serum concentration of Darexaban can be decreased when it is combined with Boceprevir.Approved, Withdrawn
BrinaseBrinase may increase the anticoagulant activities of Darexaban.Experimental
BromfenacBromfenac may increase the anticoagulant activities of Darexaban.Approved
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Darexaban.Approved, Investigational
BucillamineBucillamine may increase the anticoagulant activities of Darexaban.Investigational
BufexamacBufexamac may increase the anticoagulant activities of Darexaban.Approved, Experimental
BuflomedilBuflomedil may increase the anticoagulant activities of Darexaban.Experimental
BumadizoneBumadizone may increase the anticoagulant activities of Darexaban.Experimental
ButriptylineThe serum concentration of Butriptyline can be increased when it is combined with Darexaban.Approved
ButylphthalideButylphthalide may increase the anticoagulant activities of Darexaban.Investigational
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Darexaban.Approved
CangrelorCangrelor may increase the anticoagulant activities of Darexaban.Approved
CaplacizumabCaplacizumab may increase the anticoagulant activities of Darexaban.Investigational
CarbamazepineThe metabolism of Darexaban can be increased when combined with Carbamazepine.Approved, Investigational
Carbaspirin calciumCarbaspirin calcium may increase the anticoagulant activities of Darexaban.Experimental, Investigational
CarprofenCarprofen may increase the anticoagulant activities of Darexaban.Approved, Vet Approved, Withdrawn
CastanospermineCastanospermine may increase the anticoagulant activities of Darexaban.Experimental
CelecoxibCelecoxib may increase the anticoagulant activities of Darexaban.Approved, Investigational
CertoparinCertoparin may increase the anticoagulant activities of Darexaban.Approved, Investigational
ChloroquineChloroquine may increase the anticoagulant activities of Darexaban.Approved, Investigational, Vet Approved
ChlorotrianiseneThe serum concentration of Chlorotrianisene can be decreased when it is combined with Darexaban.Investigational, Withdrawn
Choline magnesium trisalicylateCholine magnesium trisalicylate may increase the anticoagulant activities of Darexaban.Approved
CilostazolCilostazol may increase the anticoagulant activities of Darexaban.Approved, Investigational
Citric AcidCitric Acid may increase the anticoagulant activities of Darexaban.Approved, Nutraceutical, Vet Approved
ClarithromycinThe therapeutic efficacy of Clarithromycin can be decreased when used in combination with Darexaban.Approved
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Darexaban.Approved, Investigational, Vet Approved
ClonixinClonixin may increase the anticoagulant activities of Darexaban.Approved
ClopidogrelClopidogrel may increase the anticoagulant activities of Darexaban.Approved
CloricromenCloricromen may increase the anticoagulant activities of Darexaban.Experimental
ClorindioneClorindione may increase the anticoagulant activities of Darexaban.Experimental
Collagenase clostridium histolyticumThe risk or severity of adverse effects can be increased when Darexaban is combined with Collagenase clostridium histolyticum.Approved, Investigational
Conjugated estrogensThe serum concentration of Conjugated estrogens can be decreased when it is combined with Darexaban.Approved
CurcuminCurcumin may increase the anticoagulant activities of Darexaban.Approved, Investigational
CyclophosphamideThe risk or severity of adverse effects can be increased when Darexaban is combined with Cyclophosphamide.Approved, Investigational
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Darexaban.Approved, Investigational, Vet Approved
Dabigatran etexilateDabigatran etexilate may increase the anticoagulant activities of Darexaban.Approved
DaidzeinDaidzein may decrease the anticoagulant activities of Darexaban.Experimental
DalteparinDalteparin may increase the anticoagulant activities of Darexaban.Approved
DanaparoidDanaparoid may increase the anticoagulant activities of Darexaban.Approved, Withdrawn
DasatinibDasatinib may increase the anticoagulant activities of Darexaban.Approved, Investigational
DeferasiroxThe risk or severity of adverse effects can be increased when Darexaban is combined with Deferasirox.Approved, Investigational
DefibrotideDefibrotide may increase the anticoagulant activities of Darexaban.Approved, Investigational
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Darexaban.Approved
DemegestoneThe therapeutic efficacy of Darexaban can be decreased when used in combination with Demegestone.Experimental
Deoxycholic AcidThe risk or severity of adverse effects can be increased when Darexaban is combined with Deoxycholic Acid.Approved
DersalazineDersalazine may increase the anticoagulant activities of Darexaban.Investigational
DesipramineThe serum concentration of Desipramine can be increased when it is combined with Darexaban.Approved, Investigational
DesirudinDesirudin may increase the anticoagulant activities of Darexaban.Approved
DesmoteplaseDesmoteplase may increase the anticoagulant activities of Darexaban.Investigational
DesogestrelThe therapeutic efficacy of Darexaban can be decreased when used in combination with Desogestrel.Approved
DextranDextran may increase the anticoagulant activities of Darexaban.Approved, Investigational, Vet Approved
DibenzepinThe serum concentration of Dibenzepin can be increased when it is combined with Darexaban.Experimental
DiclofenacDiclofenac may increase the anticoagulant activities of Darexaban.Approved, Vet Approved
DicoumarolDicoumarol may increase the anticoagulant activities of Darexaban.Approved
DienestrolThe serum concentration of Dienestrol can be decreased when it is combined with Darexaban.Approved, Investigational
DienogestThe therapeutic efficacy of Darexaban can be decreased when used in combination with Dienogest.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Darexaban.Approved, Investigational
DifenpiramideDifenpiramide may increase the anticoagulant activities of Darexaban.Experimental
DiflunisalDiflunisal may increase the anticoagulant activities of Darexaban.Approved, Investigational
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Darexaban.Approved
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Darexaban.Approved, Investigational
DiltiazemThe metabolism of Diltiazem can be decreased when combined with Darexaban.Approved, Investigational
DimetacrineThe serum concentration of Dimetacrine can be increased when it is combined with Darexaban.Approved, Withdrawn
DiphenadioneDiphenadione may increase the anticoagulant activities of Darexaban.Experimental
DipyridamoleDipyridamole may increase the anticoagulant activities of Darexaban.Approved
DitazoleDitazole may increase the anticoagulant activities of Darexaban.Approved, Withdrawn
DosulepinThe serum concentration of Dosulepin can be increased when it is combined with Darexaban.Approved
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Darexaban.Approved, Investigational
Drotrecogin alfaDrotrecogin alfa may increase the anticoagulant activities of Darexaban.Approved, Investigational, Withdrawn
DroxicamDroxicam may increase the anticoagulant activities of Darexaban.Withdrawn
DuvelisibDuvelisib may increase the anticoagulant activities of Darexaban.Investigational
DydrogesteroneThe therapeutic efficacy of Darexaban can be decreased when used in combination with Dydrogesterone.Approved, Investigational, Withdrawn
DyphyllineThe serum concentration of Dyphylline can be decreased when it is combined with Darexaban.Approved
E-6201E-6201 may increase the anticoagulant activities of Darexaban.Investigational
Edetic AcidEdetic Acid may increase the anticoagulant activities of Darexaban.Approved, Vet Approved
EdoxabanEdoxaban may increase the anticoagulant activities of Darexaban.Approved
EnfuvirtideThe serum concentration of Enfuvirtide can be increased when it is combined with Darexaban.Approved, Investigational
EnoxaparinEnoxaparin may increase the anticoagulant activities of Darexaban.Approved
EpimestrolEpimestrol may decrease the anticoagulant activities of Darexaban.Experimental
EpinastineEpinastine may increase the anticoagulant activities of Darexaban.Approved, Investigational
EpirizoleEpirizole may increase the anticoagulant activities of Darexaban.Approved
EplivanserinEplivanserin may increase the anticoagulant activities of Darexaban.Investigational
eplivanserineeplivanserine may increase the anticoagulant activities of Darexaban.Investigational
EpoprostenolEpoprostenol may increase the anticoagulant activities of Darexaban.Approved
EptifibatideEptifibatide may increase the anticoagulant activities of Darexaban.Approved, Investigational
EquolEquol may decrease the anticoagulant activities of Darexaban.Investigational
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Darexaban.Approved
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Darexaban.Approved
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Darexaban.Approved
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Darexaban.Approved, Investigational, Vet Approved
Estradiol acetateEstradiol acetate may decrease the anticoagulant activities of Darexaban.Approved, Investigational, Vet Approved
Estradiol cypionateEstradiol cypionate may decrease the anticoagulant activities of Darexaban.Approved, Investigational, Vet Approved
Estradiol valerateEstradiol valerate may decrease the anticoagulant activities of Darexaban.Approved, Investigational, Vet Approved
EstramustineThe serum concentration of Estramustine can be decreased when it is combined with Darexaban.Approved, Investigational
EstriolEstriol may decrease the anticoagulant activities of Darexaban.Approved, Investigational, Vet Approved
Estrogens, esterifiedThe serum concentration of Estrogens, esterified can be decreased when it is combined with Darexaban.Approved
EstroneEstrone may decrease the anticoagulant activities of Darexaban.Approved
Estrone sulfateThe serum concentration of Estrone sulfate can be decreased when it is combined with Darexaban.Approved
EtanerceptEtanercept may increase the anticoagulant activities of Darexaban.Approved, Investigational
EthenzamideEthenzamide may increase the anticoagulant activities of Darexaban.Experimental
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Darexaban.Approved
Ethyl biscoumacetateEthyl biscoumacetate may increase the anticoagulant activities of Darexaban.Withdrawn
EthynodiolThe therapeutic efficacy of Darexaban can be decreased when used in combination with Ethynodiol.Experimental
EtodolacEtodolac may increase the anticoagulant activities of Darexaban.Approved, Investigational, Vet Approved
EtofenamateEtofenamate may increase the anticoagulant activities of Darexaban.Approved, Investigational
EtonogestrelThe therapeutic efficacy of Darexaban can be decreased when used in combination with Etonogestrel.Approved, Investigational
EtoricoxibEtoricoxib may increase the anticoagulant activities of Darexaban.Approved, Investigational
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Darexaban.Approved
Evening primrose oilEvening primrose oil may increase the anticoagulant activities of Darexaban.Investigational, Nutraceutical
ExisulindExisulind may increase the anticoagulant activities of Darexaban.Investigational
FelbinacFelbinac may increase the anticoagulant activities of Darexaban.Experimental
FenbufenFenbufen may increase the anticoagulant activities of Darexaban.Approved
FenoprofenFenoprofen may increase the anticoagulant activities of Darexaban.Approved
FentiazacFentiazac may increase the anticoagulant activities of Darexaban.Experimental
FeprazoneFeprazone may increase the anticoagulant activities of Darexaban.Experimental
Ferulic acidFerulic acid may increase the anticoagulant activities of Darexaban.Experimental
FibrinolysinFibrinolysin may increase the anticoagulant activities of Darexaban.Investigational
FloctafenineFloctafenine may increase the anticoagulant activities of Darexaban.Approved, Withdrawn
FluindioneDarexaban may increase the anticoagulant activities of Fluindione.Approved, Investigational
FlunixinFlunixin may increase the anticoagulant activities of Darexaban.Vet Approved
FlunoxaprofenFlunoxaprofen may increase the anticoagulant activities of Darexaban.Experimental
FlurbiprofenFlurbiprofen may increase the anticoagulant activities of Darexaban.Approved, Investigational
FondaparinuxFondaparinux may increase the anticoagulant activities of Darexaban.Approved, Investigational
Fondaparinux sodiumFondaparinux sodium may increase the anticoagulant activities of Darexaban.Approved, Investigational
GabexateDarexaban may increase the anticoagulant activities of Gabexate.Investigational
GarlicThe serum concentration of Darexaban can be decreased when it is combined with Garlic.Approved
GenisteinGenistein may decrease the anticoagulant activities of Darexaban.Investigational
GestodeneThe therapeutic efficacy of Darexaban can be decreased when used in combination with Gestodene.Approved, Investigational
GestonoroneThe therapeutic efficacy of Darexaban can be decreased when used in combination with Gestonorone.Experimental
GestrinoneThe therapeutic efficacy of Darexaban can be decreased when used in combination with Gestrinone.Approved
GuacetisalGuacetisal may increase the anticoagulant activities of Darexaban.Experimental
HeminHemin may increase the anticoagulant activities of Darexaban.Approved, Investigational
Hemoglobin crosfumarilHemoglobin crosfumaril may increase the anticoagulant activities of Darexaban.Experimental
HeparinHeparin may increase the anticoagulant activities of Darexaban.Approved, Investigational
HexestrolThe serum concentration of Hexestrol can be decreased when it is combined with Darexaban.Withdrawn
HigenamineHigenamine may increase the anticoagulant activities of Darexaban.Investigational
Hydroxyprogesterone caproateThe therapeutic efficacy of Darexaban can be decreased when used in combination with Hydroxyprogesterone caproate.Approved, Investigational
HydroxytyrosolHydroxytyrosol may increase the anticoagulant activities of Darexaban.Investigational
Ibritumomab tiuxetanThe risk or severity of adverse effects can be increased when Darexaban is combined with Ibritumomab tiuxetan.Approved, Investigational
IbrutinibThe risk or severity of adverse effects can be increased when Ibrutinib is combined with Darexaban.Approved
IbudilastIbudilast may increase the anticoagulant activities of Darexaban.Approved, Investigational
IbuprofenIbuprofen may increase the anticoagulant activities of Darexaban.Approved
IbuproxamIbuproxam may increase the anticoagulant activities of Darexaban.Withdrawn
IcatibantIcatibant may increase the anticoagulant activities of Darexaban.Approved, Investigational
Icosapent ethylIcosapent ethyl may increase the anticoagulant activities of Darexaban.Approved, Investigational, Nutraceutical
IdraparinuxIdraparinux may increase the anticoagulant activities of Darexaban.Investigational
IfenprodilIfenprodil may increase the anticoagulant activities of Darexaban.Approved, Investigational, Withdrawn
IfetrobanIfetroban may increase the anticoagulant activities of Darexaban.Investigational
IloprostIloprost may increase the anticoagulant activities of Darexaban.Approved, Investigational
Imidazole salicylateImidazole salicylate may increase the anticoagulant activities of Darexaban.Experimental
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Darexaban.Approved
IndobufenIndobufen may increase the anticoagulant activities of Darexaban.Investigational
IndomethacinIndomethacin may increase the anticoagulant activities of Darexaban.Approved, Investigational
IndoprofenIndoprofen may increase the anticoagulant activities of Darexaban.Withdrawn
IprindoleThe serum concentration of Iprindole can be increased when it is combined with Darexaban.Experimental
IsoxicamIsoxicam may increase the anticoagulant activities of Darexaban.Withdrawn
KebuzoneKebuzone may increase the anticoagulant activities of Darexaban.Experimental
KetanserinKetanserin may increase the anticoagulant activities of Darexaban.Investigational
KetoprofenKetoprofen may increase the anticoagulant activities of Darexaban.Approved, Vet Approved
KetorolacKetorolac may increase the anticoagulant activities of Darexaban.Approved
LeflunomideLeflunomide may increase the anticoagulant activities of Darexaban.Approved, Investigational
LepirudinLepirudin may increase the anticoagulant activities of Darexaban.Approved
LetaxabanLetaxaban may increase the anticoagulant activities of Darexaban.Investigational
LevonorgestrelThe therapeutic efficacy of Darexaban can be decreased when used in combination with Levonorgestrel.Approved, Investigational
LimaprostThe risk or severity of adverse effects can be increased when Limaprost is combined with Darexaban.Approved, Investigational
LinsidomineLinsidomine may increase the anticoagulant activities of Darexaban.Experimental
LisofyllineLisofylline may increase the anticoagulant activities of Darexaban.Investigational
LofepramineThe serum concentration of Lofepramine can be increased when it is combined with Darexaban.Experimental
LonazolacLonazolac may increase the anticoagulant activities of Darexaban.Experimental
LornoxicamLornoxicam may increase the anticoagulant activities of Darexaban.Approved, Investigational
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Darexaban.Approved, Investigational
LoxoprofenLoxoprofen may increase the anticoagulant activities of Darexaban.Approved, Investigational
LumiracoxibLumiracoxib may increase the anticoagulant activities of Darexaban.Approved, Investigational
Magnesium salicylateMagnesium salicylate may increase the anticoagulant activities of Darexaban.Approved
MasoprocolMasoprocol may increase the anticoagulant activities of Darexaban.Approved, Investigational
Meclofenamic acidMeclofenamic acid may increase the anticoagulant activities of Darexaban.Approved, Vet Approved
MedrogestoneThe therapeutic efficacy of Darexaban can be decreased when used in combination with Medrogestone.Approved
Medroxyprogesterone acetateThe therapeutic efficacy of Darexaban can be decreased when used in combination with Medroxyprogesterone acetate.Approved, Investigational
Mefenamic acidMefenamic acid may increase the anticoagulant activities of Darexaban.Approved
Megestrol acetateThe therapeutic efficacy of Darexaban can be decreased when used in combination with Megestrol acetate.Approved, Investigational, Vet Approved
MelagatranDarexaban may increase the anticoagulant activities of Melagatran.Experimental
MelitracenThe serum concentration of Melitracen can be increased when it is combined with Darexaban.Experimental, Investigational
MeloxicamMeloxicam may increase the anticoagulant activities of Darexaban.Approved, Vet Approved
MesalazineMesalazine may increase the anticoagulant activities of Darexaban.Approved
MestranolThe serum concentration of Mestranol can be decreased when it is combined with Darexaban.Approved
MetamizoleMetamizole may increase the anticoagulant activities of Darexaban.Approved, Investigational, Withdrawn
MethallenestrilThe serum concentration of Methallenestril can be decreased when it is combined with Darexaban.Experimental
Methyl salicylateMethyl salicylate may increase the anticoagulant activities of Darexaban.Approved, Vet Approved
MethylergometrineThe serum concentration of Methylergometrine can be increased when it is combined with Darexaban.Approved
MethylestrenoloneThe therapeutic efficacy of Darexaban can be decreased when used in combination with Methylestrenolone.Experimental
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Darexaban.Approved, Illicit
MilrinoneMilrinone may increase the anticoagulant activities of Darexaban.Approved
MizoribineMizoribine may increase the anticoagulant activities of Darexaban.Investigational
MofebutazoneMofebutazone may increase the anticoagulant activities of Darexaban.Experimental
MoxestrolMoxestrol may decrease the anticoagulant activities of Darexaban.Experimental
Mycophenolate mofetilMycophenolate mofetil may increase the anticoagulant activities of Darexaban.Approved, Investigational
Mycophenolic acidMycophenolic acid may increase the anticoagulant activities of Darexaban.Approved
NabumetoneNabumetone may increase the anticoagulant activities of Darexaban.Approved
NadroparinNadroparin may increase the anticoagulant activities of Darexaban.Approved, Investigational
NafamostatNafamostat may increase the anticoagulant activities of Darexaban.Approved, Investigational
NaftifineNaftifine may increase the anticoagulant activities of Darexaban.Approved
NaftopidilNaftopidil may increase the anticoagulant activities of Darexaban.Investigational
NaproxenNaproxen may increase the anticoagulant activities of Darexaban.Approved, Vet Approved
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Darexaban.Approved, Withdrawn
NepafenacNepafenac may increase the anticoagulant activities of Darexaban.Approved, Investigational
NifenazoneNifenazone may increase the anticoagulant activities of Darexaban.Experimental
Niflumic AcidNiflumic Acid may increase the anticoagulant activities of Darexaban.Approved
NimesulideNimesulide may increase the anticoagulant activities of Darexaban.Approved, Investigational, Withdrawn
NintedanibThe risk or severity of adverse effects can be increased when Darexaban is combined with Nintedanib.Approved
NitroaspirinNitroaspirin may increase the anticoagulant activities of Darexaban.Investigational
NomegestrolThe therapeutic efficacy of Darexaban can be decreased when used in combination with Nomegestrol.Approved
NorethisteroneThe therapeutic efficacy of Darexaban can be decreased when used in combination with Norethisterone.Approved
NorgestrienoneThe therapeutic efficacy of Darexaban can be decreased when used in combination with Norgestrienone.Experimental
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Darexaban.Approved
ObinutuzumabThe risk or severity of adverse effects can be increased when Darexaban is combined with Obinutuzumab.Approved, Investigational
OlopatadineOlopatadine may increase the anticoagulant activities of Darexaban.Approved
OlsalazineOlsalazine may increase the anticoagulant activities of Darexaban.Approved
Omacetaxine mepesuccinateThe risk or severity of bleeding can be increased when Darexaban is combined with Omacetaxine mepesuccinate.Approved, Investigational
Omega-3 fatty acidsOmega-3 fatty acids may increase the anticoagulant activities of Darexaban.Approved, Nutraceutical
Omega-3-carboxylic acidsThe therapeutic efficacy of Darexaban can be increased when used in combination with Omega-3-carboxylic acids.Approved, Investigational
OpipramolThe serum concentration of Opipramol can be increased when it is combined with Darexaban.Investigational
OrgoteinOrgotein may increase the anticoagulant activities of Darexaban.Vet Approved
OtamixabanOtamixaban may increase the anticoagulant activities of Darexaban.Investigational
OxaprozinOxaprozin may increase the anticoagulant activities of Darexaban.Approved
OxyphenbutazoneOxyphenbutazone may increase the anticoagulant activities of Darexaban.Approved, Withdrawn
OzagrelOzagrel may increase the anticoagulant activities of Darexaban.Investigational
ParecoxibParecoxib may increase the anticoagulant activities of Darexaban.Approved
ParnaparinParnaparin may increase the anticoagulant activities of Darexaban.Approved, Investigational
ParthenolideParthenolide may increase the anticoagulant activities of Darexaban.Approved, Investigational
Pentaerythritol TetranitratePentaerythritol Tetranitrate may increase the anticoagulant activities of Darexaban.Approved
Pentosan PolysulfatePentosan Polysulfate may increase the anticoagulant activities of Darexaban.Approved
PentoxifyllinePentoxifylline may increase the anticoagulant activities of Darexaban.Approved, Investigational
PethidineThe risk or severity of adverse effects can be increased when Darexaban is combined with Pethidine.Approved
PhenindionePhenindione may increase the anticoagulant activities of Darexaban.Approved, Investigational
PhenprocoumonPhenprocoumon may increase the anticoagulant activities of Darexaban.Approved, Investigational
Phenyl aminosalicylatePhenyl aminosalicylate may increase the anticoagulant activities of Darexaban.Approved
PhenylbutazonePhenylbutazone may increase the anticoagulant activities of Darexaban.Approved, Vet Approved
PicotamidePicotamide may increase the anticoagulant activities of Darexaban.Experimental
PimecrolimusPimecrolimus may increase the anticoagulant activities of Darexaban.Approved, Investigational
PirfenidonePirfenidone may increase the anticoagulant activities of Darexaban.Approved, Investigational
PiroxicamPiroxicam may increase the anticoagulant activities of Darexaban.Approved, Investigational
PirprofenPirprofen may increase the anticoagulant activities of Darexaban.Experimental
Polyestradiol phosphatePolyestradiol phosphate may decrease the anticoagulant activities of Darexaban.Approved
PranoprofenPranoprofen may increase the anticoagulant activities of Darexaban.Experimental, Investigational
PrasugrelPrasugrel may increase the anticoagulant activities of Darexaban.Approved
ProgesteroneThe therapeutic efficacy of Darexaban can be decreased when used in combination with Progesterone.Approved, Vet Approved
ProglumetacinProglumetacin may increase the anticoagulant activities of Darexaban.Experimental
PromegestoneThe therapeutic efficacy of Darexaban can be decreased when used in combination with Promegestone.Experimental
PromestrienePromestriene may decrease the anticoagulant activities of Darexaban.Investigational
PropacetamolPropacetamol may increase the anticoagulant activities of Darexaban.Approved, Investigational
PropyphenazonePropyphenazone may increase the anticoagulant activities of Darexaban.Experimental
ProquazoneProquazone may increase the anticoagulant activities of Darexaban.Experimental
Protein CProtein C may increase the anticoagulant activities of Darexaban.Approved
Protein S humanDarexaban may increase the anticoagulant activities of Protein S human.Approved
ProtocatechualdehydeProtocatechualdehyde may increase the anticoagulant activities of Darexaban.Approved
ProtriptylineThe serum concentration of Protriptyline can be increased when it is combined with Darexaban.Approved
PTC299PTC299 may increase the anticoagulant activities of Darexaban.Investigational
QuinestrolQuinestrol may decrease the anticoagulant activities of Darexaban.Approved
RamatrobanRamatroban may increase the anticoagulant activities of Darexaban.Investigational
RelcovaptanRelcovaptan may increase the anticoagulant activities of Darexaban.Investigational
ResveratrolResveratrol may increase the anticoagulant activities of Darexaban.Approved, Experimental, Investigational
ReteplaseReteplase may increase the anticoagulant activities of Darexaban.Approved, Investigational
ReviparinReviparin may increase the anticoagulant activities of Darexaban.Approved, Investigational
RidogrelRidogrel may increase the anticoagulant activities of Darexaban.Approved
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Darexaban.Approved
RivaroxabanDarexaban may increase the anticoagulant activities of Rivaroxaban.Approved
RofecoxibRofecoxib may increase the anticoagulant activities of Darexaban.Approved, Investigational, Withdrawn
RosiglitazoneRosiglitazone may increase the anticoagulant activities of Darexaban.Approved, Investigational
SalicylamideSalicylamide may increase the anticoagulant activities of Darexaban.Approved
Salicylic acidSalicylic acid may increase the anticoagulant activities of Darexaban.Approved, Investigational, Vet Approved
SalsalateSalsalate may increase the anticoagulant activities of Darexaban.Approved
SarpogrelateSarpogrelate may increase the anticoagulant activities of Darexaban.Investigational
SaruplaseSaruplase may increase the anticoagulant activities of Darexaban.Experimental
SecoisolariciresinolSecoisolariciresinol may decrease the anticoagulant activities of Darexaban.Investigational
SelexipagSelexipag may increase the anticoagulant activities of Darexaban.Approved
SemapimodSemapimod may increase the anticoagulant activities of Darexaban.Investigational
SeratrodastSeratrodast may increase the anticoagulant activities of Darexaban.Approved
SerrapeptaseSerrapeptase may increase the anticoagulant activities of Darexaban.Investigational
SevofluraneSevoflurane may increase the anticoagulant activities of Darexaban.Approved, Vet Approved
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Darexaban.Approved, Investigational
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Darexaban.Approved
SRT501SRT501 may increase the anticoagulant activities of Darexaban.Investigational
St. John's WortThe metabolism of Darexaban can be increased when combined with St. John's Wort.Approved, Investigational, Nutraceutical
StreptokinaseStreptokinase may increase the anticoagulant activities of Darexaban.Approved, Investigational
SugammadexSugammadex may increase the anticoagulant activities of Darexaban.Approved
SulfasalazineSulfasalazine may increase the anticoagulant activities of Darexaban.Approved
SulindacSulindac may increase the anticoagulant activities of Darexaban.Approved, Investigational
SulodexideSulodexide may increase the anticoagulant activities of Darexaban.Approved, Investigational
SuprofenSuprofen may increase the anticoagulant activities of Darexaban.Approved, Withdrawn
SuxibuzoneSuxibuzone may increase the anticoagulant activities of Darexaban.Experimental
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be decreased when it is combined with Darexaban.Approved
Synthetic Conjugated Estrogens, BSynthetic Conjugated Estrogens, B may decrease the anticoagulant activities of Darexaban.Approved
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Darexaban.Approved, Investigational
TarenflurbilTarenflurbil may increase the anticoagulant activities of Darexaban.Investigational
TemsirolimusThe risk or severity of adverse effects can be increased when Darexaban is combined with Temsirolimus.Approved
TenecteplaseTenecteplase may increase the anticoagulant activities of Darexaban.Approved
TenidapTenidap may increase the anticoagulant activities of Darexaban.Experimental
TenoxicamTenoxicam may increase the anticoagulant activities of Darexaban.Approved
TepoxalinTepoxalin may increase the anticoagulant activities of Darexaban.Vet Approved
TeriflunomideTeriflunomide may increase the anticoagulant activities of Darexaban.Approved
TesmilifeneTesmilifene may increase the anticoagulant activities of Darexaban.Investigational
Testosterone cypionateThe therapeutic efficacy of Darexaban can be increased when used in combination with Testosterone cypionate.Approved
Testosterone enanthateThe therapeutic efficacy of Darexaban can be increased when used in combination with Testosterone enanthate.Approved
Testosterone undecanoateThe therapeutic efficacy of Darexaban can be increased when used in combination with Testosterone undecanoate.Approved, Investigational
TheophyllineThe serum concentration of Theophylline can be decreased when it is combined with Darexaban.Approved
TianeptineThe serum concentration of Tianeptine can be increased when it is combined with Darexaban.Approved, Investigational
Tiaprofenic acidTiaprofenic acid may increase the anticoagulant activities of Darexaban.Approved
TiboloneTibolone may increase the anticoagulant activities of Darexaban.Approved, Investigational
TicagrelorTicagrelor may increase the anticoagulant activities of Darexaban.Approved
TiclopidineTiclopidine may increase the anticoagulant activities of Darexaban.Approved
TinoridineTinoridine may increase the anticoagulant activities of Darexaban.Investigational
TinzaparinTinzaparin may increase the anticoagulant activities of Darexaban.Approved
TioclomarolTioclomarol may increase the anticoagulant activities of Darexaban.Experimental
TipranavirThe serum concentration of Darexaban can be decreased when it is combined with Tipranavir.Approved, Investigational
TirofibanTirofiban may increase the anticoagulant activities of Darexaban.Approved
Tolfenamic AcidTolfenamic Acid may increase the anticoagulant activities of Darexaban.Approved, Investigational
TolmetinTolmetin may increase the anticoagulant activities of Darexaban.Approved
TositumomabThe risk or severity of adverse effects can be increased when Darexaban is combined with Tositumomab.Approved, Investigational
TranilastTranilast may increase the anticoagulant activities of Darexaban.Approved, Investigational
TrapidilTrapidil may increase the anticoagulant activities of Darexaban.Approved
TreprostinilTreprostinil may increase the anticoagulant activities of Darexaban.Approved, Investigational
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Darexaban.Approved, Investigational
TribenosideTribenoside may increase the anticoagulant activities of Darexaban.Experimental
TriflusalTriflusal may increase the anticoagulant activities of Darexaban.Approved, Investigational
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Darexaban.Approved
TriptolideTriptolide may increase the anticoagulant activities of Darexaban.Investigational
Trolamine salicylateTrolamine salicylate may increase the anticoagulant activities of Darexaban.Approved
TroxerutinDarexaban may increase the anticoagulant activities of Troxerutin.Investigational
UrokinaseUrokinase may increase the anticoagulant activities of Darexaban.Approved, Investigational, Withdrawn
ValdecoxibValdecoxib may increase the anticoagulant activities of Darexaban.Approved, Investigational, Withdrawn
Valproic AcidThe serum concentration of Valproic Acid can be decreased when it is combined with Darexaban.Approved, Investigational
VerapamilThe metabolism of Verapamil can be decreased when combined with Darexaban.Approved
Vitamin EVitamin E may increase the anticoagulant activities of Darexaban.Approved, Nutraceutical, Vet Approved
VorapaxarThe risk or severity of adverse effects can be increased when Vorapaxar is combined with Darexaban.Approved
WarfarinWarfarin may increase the anticoagulant activities of Darexaban.Approved
XimelagatranXimelagatran may increase the anticoagulant activities of Darexaban.Approved, Investigational, Withdrawn
ZaltoprofenZaltoprofen may increase the anticoagulant activities of Darexaban.Approved, Investigational
ZeranolZeranol may decrease the anticoagulant activities of Darexaban.Vet Approved
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Darexaban.Approved
ZileutonZileuton may increase the anticoagulant activities of Darexaban.Approved, Investigational, Withdrawn
ZomepiracZomepirac may increase the anticoagulant activities of Darexaban.Withdrawn
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Compound
9912771
PubChem Substance
347828557
ChemSpider
8088422
BindingDB
50358252
ChEMBL
CHEMBL1922235
Wikipedia
Darexaban

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedNot AvailableHealthy Elderly Subjects / Pharmacokinetics of YM1501
1CompletedNot AvailableHealthy Volunteers / Pharmacodynamic Interaction2
1CompletedNot AvailableHealthy Volunteers / Pharmacodynamic and Pharmacokinetic Interaction1
1CompletedNot AvailableHealthy Volunteers / Pharmacokinetics of Darexaban and Metabolites2
1CompletedNot AvailableHealthy Volunteers / Pharmacokinetics of Digoxin1
1CompletedNot AvailableHealthy Volunteers / Pharmacokinetics of YM1503
1CompletedBasic ScienceCaucasian / Healthy Volunteers / Japanese / Pharmacodynamics / Pharmacokinetics1
1CompletedBasic ScienceHealthy Male Subjects / Pharmacokinetics1
2CompletedPreventionAcute Coronary Syndromes (ACS)1
2CompletedPreventionArthroplasty, Replacement, Knee1
2CompletedPreventionNonvalvular Atrial Fibrillation2
2CompletedPreventionThromboembolism2
2, 3CompletedPreventionArthroplasty, Replacement, Hip / Venous Thromboembolism1
2, 3CompletedPreventionVenous Thromboembolism2
3CompletedPreventionVenous Thromboembolism4

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0291 mg/mLALOGPS
logP4.03ALOGPS
logP2.96ChemAxon
logS-4.2ALOGPS
pKa (Strongest Acidic)8.32ChemAxon
pKa (Strongest Basic)8.95ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area94.14 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity140.91 m3·mol-1ChemAxon
Polarizability52.36 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as benzanilides. These are aromatic compounds containing an anilide group in which the carboxamide group is substituted with a benzene ring. They have the general structure RNC(=O)R', where R,R'= benzene.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Anilides
Direct Parent
Benzanilides
Alternative Parents
Aminobenzoic acids and derivatives / Benzamides / Aniline and substituted anilines / Anisoles / Benzoyl derivatives / Dialkylarylamines / Methoxybenzenes / Phenoxy compounds / 1-hydroxy-2-unsubstituted benzenoids / 1,4-diazepanes
show 8 more
Substituents
Benzanilide / Aminobenzoic acid or derivatives / Benzamide / Benzoic acid or derivatives / Benzoyl / Phenol ether / Tertiary aliphatic/aromatic amine / Dialkylarylamine / Aniline or substituted anilines / Phenoxy compound
show 25 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
Not Available

Drug created on October 20, 2016 15:50 / Updated on May 02, 2018 01:39