Detoxifying Agents for Antineoplastic Treatment

Name
Detoxifying Agents for Antineoplastic Treatment
Accession Number
DBCAT002110
Description
Not Available
ATC Classification
Drugs
DrugDrug Description
PaliferminA form of recombinant human keratinocyte growth factor used to prevent and treat oral mucositis following radiation or chemotherapy.
DexrazoxaneA cytoprotective drug used to prevent and improve cardiomyopathy associated with doxorubicin treatment for metastatic breast cancer.
LeucovorinA folate analog used to treat the toxic effects of methotrexate and other folate antagonists, to treat megaloblastic anemia, and to provide palliative treatment of colorectal cancer.
AmifostineA cytoprotective adjuvant used for reduction in the cumulative renal toxicity in patients with ovarian cancer and moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer.
GlucarpidaseA carboxypeptidase enzyme used to treat toxic plasma methotrexate concentrations by providing an alternate elimination pathway for methotrexate in patients who have impaired renal function.
Coenzyme MA uroprotective agent used for the reduction and prophylaxis of oxazaphosphorine-induced toxicity in the urinary tract.
LevoleucovorinA folate analog used after high dose methotrexate for osteosarcoma, to reduce the toxic effects of folate analogs, and with 5-fluorouracil in palliative treatment of advanced metastatic colorectal cancer.
RasburicaseA recombinant form of urate-oxidase enzyme used to treat hyperuricemia following chemotherapy for leukemias and non-Hodgkin's lymphoma.
Drugs & Drug Targets
DrugTargetType
PaliferminFibroblast growth factor receptor 2target
PaliferminNeuropilin-1target
PaliferminFibroblast growth factor receptor 1target
PaliferminFibroblast growth factor receptor 4target
PaliferminFibroblast growth factor receptor 3target
PaliferminBasement membrane-specific heparan sulfate proteoglycan core proteintarget
DexrazoxaneDNA topoisomerase 2-alphatarget
DexrazoxaneDNA topoisomerase 2-betatarget
LeucovorinSolute carrier family 22 member 8transporter
AmifostineAlkaline phosphatase, placental-liketarget
AmifostineAlkaline phosphatase, tissue-nonspecific isozymeenzyme
GlucarpidaseMethotrexatetarget
Coenzyme MGlutathione reductase, mitochondrialenzyme
LevoleucovorinSerine hydroxymethyltransferasetarget
RasburicaseUric acidtarget