Agents Acting on the Renin-Angiotensin System

Name
Agents Acting on the Renin-Angiotensin System
Accession Number
DBCAT002171
Description
Not Available
ATC Classification
Drugs
DrugDrug Description
Candesartan cilexetilAn angiotensin receptor blocker used to treat hypertension, systolic hypertension, left ventricular hypertrophy, and delay progression of diabetic nephropathy.
ValsartanAn angiotensin-receptor blocker used to manage hypertension alone or in combination with other antihypertensive agents and to manage heart failure in patients who are intolerant to ACE inhibitors.
RamiprilAn ACE inhibitor used for the management of hypertension and the reduction of cardiovascular mortality following myocardial infarction in hemodynamically stable patients with clinical signs of congestive heart failure.
RemikirenFor the treatment of hypertension and heart failure
OlmesartanAn angiotensin receptor blocker (ARB) used in the treatment of hypertension.
FosinoprilAn ACE inhibitor used to treat mild to moderate hypertension, congestive heart failure, and to slow the progression of renal disease in hypertensive diabetics.
TrandolaprilA prodrug of an ACE inhibitor used to treat hypertension, congestive heart failure, and to improve survival following a myocardial infarction.
BenazeprilAn ACE inhibitor prodrug used to treat hypertension.
EnalaprilA prodrug of an ACE inhibitor used to treat hypertension and congestive heart failure.
LosartanAn angiotensin receptor blocker used to treat hypertension and diabetic nephropathy, and is used to reduce the risk of stroke.
MoexiprilAn angiotensin converting enzyme inhibitor prodrug used to treat hypertension.
LisinoprilAn ACE inhibitor used to treat hypertension, heart failure, and acute myocardial infarction.
PerindoprilAn ACE inhibitor prodrug used to treat hypertension, mild to moderate congestive heart failure, and to reduce cardiovascular risk in patients with hypertension or post-myocardial infarction.
EprosartanAn ARB used to treat hypertension, diabetic nephropathy, and congestive heart failure.
QuinaprilAn ACE inhibitor prodrug used to treat hypertension, congestive heart failure, and slow rate of progression of renal disease.
TelmisartanAn ARB used to treat hypertension, diabetic nephropathy, and congestive heart failure.
IrbesartanAn angiotensin receptor blocker used to treat hypertension, delay progression of diabetic nephropathy, and treat congestive heart failure.
CaptoprilAn ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy.
CilazaprilAn ACE inhibitor used for the management of hypertension and heart failure.
SpiraprilSpirapril is an ACE inhibitor class drug used to treat hypertension.
TasosartanTasosartan is infrequently in the treatment of hypertension and heart failure.
Azilsartan medoxomilAn angiotensin II receptor blocker used to treat hypertension.
TemocaprilTemocapril is an ACE inhibitor primarily indicated in the treatment of hypertension and congestive heart failure, diabetic nephropathy, and improvement of prognosis for coronary artery diseases (including acute myocardial infarction).
AliskirenA direct renin inhibitor used to manage hypertension.
FimasartanUsed for the treatment of hypertension and heart failure .
ImidaprilImidapril has been investigated for the treatment of Kidney, Polycystic, Autosomal Dominant.
ZofenoprilZofenopril is employed as both a cardioprotective and anti-hypertensive agent. It is an angiotensin-converting enzyme (ACE) inhibitor.
DelaprilNot Annotated
CandesartanCandesartan is an angiotensin-receptor blocker (ARB) that may be used alone or with other agents to treat hypertension. It is available as a prodrug in the form of Candesartan cilexetil.
SaprisartanSaprisartan is used in the treatment of hypertension and heart failure.
SaralasinNot Annotated
ForasartanFor the treatment of hypertension.
EnalaprilatAn antihypertensive agent used for the management of hypertension when oral therapy is not practical.
OmapatrilatFor the treatment of hypertension.
RescinnamineFor the treatment of hypertension.
BenazeprilatNot Annotated
EnalkirenNot Available
VTP-27999VTP-27999 has been used in trials studying the basic science of Renal Function.
FosinoprilatFosinoprilat is the active phosphinic acid metabolite of prodrug fosinopril, which is activated by esterases in vivo. It binds zinc with phosphinic acid group.
RamiprilatThe active metabolite of the prodrug Ramipril.
PerindoprilatThe active metabolite of the prodrug Perindopril.
QuinaprilatThe active metabolite of the prodrug quinapril.
TrandolaprilatThe active metabolite of the prodrug Trandolapril.
MoexiprilatThe active metabolite of the prodrug Moexipril.
Quinoline Yellow WSA yellow colouring used around the world as a dye for food and medications.
CilazaprilatNot Annotated
N-(2-Aminoethyl)-1-aziridineethanamineAn experimental ACE2 inhibitor for the treatment of cardiovascular disease and Severe Acute Respiratory Syndrome.
Drugs & Drug Targets
DrugTargetType
Candesartan cilexetilType-1 angiotensin II receptortarget
Candesartan cilexetilCytochrome P450 2C8enzyme
Candesartan cilexetilCytochrome P450 2C9enzyme
Candesartan cilexetilP-glycoprotein 1transporter
Candesartan cilexetilUDP-glucuronosyltransferase 1-3enzyme
Candesartan cilexetilProstaglandin G/H synthase 1enzyme
ValsartanType-1 angiotensin II receptortarget
ValsartanCytochrome P450 2C9enzyme
ValsartanSolute carrier organic anion transporter family member 1B3transporter
ValsartanSolute carrier organic anion transporter family member 1B1transporter
ValsartanCanalicular multispecific organic anion transporter 1transporter
RamiprilAngiotensin-converting enzymetarget
RamiprilSolute carrier family 15 member 1transporter
RamiprilSolute carrier family 15 member 2transporter
RamiprilCholinesteraseenzyme
RamiprilB1 bradykinin receptortarget
RemikirenRenintarget
OlmesartanType-1 angiotensin II receptortarget
OlmesartanCanalicular multispecific organic anion transporter 1transporter
OlmesartanSolute carrier organic anion transporter family member 1B3transporter
OlmesartanSolute carrier organic anion transporter family member 1B1transporter
OlmesartanBile salt export pumptransporter
FosinoprilAngiotensin-converting enzymetarget
FosinoprilSolute carrier family 15 member 1transporter
FosinoprilSolute carrier family 15 member 2transporter
TrandolaprilAngiotensin-converting enzymetarget
TrandolaprilSolute carrier family 15 member 1transporter
TrandolaprilSolute carrier family 15 member 2transporter
TrandolaprilLiver carboxylesterase 1enzyme
BenazeprilAngiotensin-converting enzymetarget
BenazeprilMethylenetetrahydrofolate reductaseenzyme
BenazeprilSolute carrier family 15 member 1transporter
BenazeprilSolute carrier family 15 member 2transporter
EnalaprilAngiotensin-converting enzymetarget
EnalaprilP-glycoprotein 1transporter
EnalaprilSolute carrier family 15 member 1transporter
EnalaprilSolute carrier family 22 member 6transporter
EnalaprilSolute carrier family 22 member 8transporter
EnalaprilSolute carrier family 22 member 7transporter
EnalaprilSolute carrier organic anion transporter family member 1A2transporter
EnalaprilSerum albumincarrier
LosartanType-1 angiotensin II receptortarget
LosartanCytochrome P450 3A4enzyme
LosartanCytochrome P450 2C9enzyme
LosartanP-glycoprotein 1transporter
LosartanSolute carrier family 22 member 6transporter
LosartanUDP-glucuronosyltransferase 1-1enzyme
LosartanUDP-glucuronosyltransferase 1-3enzyme
LosartanUDP-glucuronosyltransferase 1-10enzyme
LosartanUDP-glucuronosyltransferase 2B7enzyme
LosartanUDP-glucuronosyltransferase 2B17enzyme
LosartanCytochrome P450 2C19enzyme
LosartanSerum albumincarrier
LosartanSolute carrier family 22 member 12transporter
LosartanSolute carrier family 2, facilitated glucose transporter member 9transporter
LosartanBile salt export pumptransporter
LosartanCytochrome P450 2C8enzyme
MoexiprilAngiotensin-converting enzymetarget
MoexiprilSolute carrier family 15 member 1transporter
MoexiprilSolute carrier family 15 member 2transporter
LisinoprilAngiotensin-converting enzymetarget
LisinoprilSolute carrier family 15 member 1transporter
LisinoprilSolute carrier family 15 member 2transporter
LisinoprilRenintarget
PerindoprilAngiotensin-converting enzymetarget
PerindoprilSolute carrier family 15 member 1transporter
PerindoprilSolute carrier family 15 member 2transporter
PerindoprilCholinesteraseenzyme
PerindoprilSecreted frizzled-related protein 4target
EprosartanType-1 angiotensin II receptortarget
EprosartanCanalicular multispecific organic anion transporter 1transporter
QuinaprilAngiotensin-converting enzymetarget
QuinaprilSolute carrier family 15 member 1transporter
QuinaprilSolute carrier family 15 member 2transporter
QuinaprilSolute carrier family 22 member 8transporter
QuinaprilLiver carboxylesterase 1enzyme
QuinaprilSerum albumincarrier
TelmisartanType-1 angiotensin II receptortarget
TelmisartanPeroxisome proliferator-activated receptor gammatarget
TelmisartanP-glycoprotein 1transporter
TelmisartanCanalicular multispecific organic anion transporter 1transporter
TelmisartanATP-binding cassette sub-family G member 2transporter
TelmisartanCytochrome P450 2C19enzyme
TelmisartanBile salt export pumptransporter
TelmisartanUDP-glucuronosyltransferase 1-3enzyme
IrbesartanType-1 angiotensin II receptortarget
IrbesartanTranscription factor AP-1target
IrbesartanCytochrome P450 2C9enzyme
IrbesartanCytochrome P450 2C8enzyme
IrbesartanUDP-glucuronosyltransferase 1-3enzyme
IrbesartanProstaglandin G/H synthase 1enzyme
IrbesartanCytochrome P450 3A4enzyme
IrbesartanSerum albumincarrier
Irbesartanalpha1-acid glycoproteincarrier
CaptoprilAngiotensin-converting enzymetarget
CaptoprilSerum albumincarrier
Captopril72 kDa type IV collagenasetarget
CaptoprilMatrix metalloproteinase-9target
CaptoprilP-glycoprotein 1transporter
CaptoprilSolute carrier family 15 member 1transporter
CaptoprilSolute carrier family 22 member 6transporter
CaptoprilLeukotriene A-4 hydrolasetarget
CaptoprilB1 bradykinin receptortarget
CilazaprilAngiotensin-converting enzymetarget
CilazaprilP-glycoprotein 1transporter
CilazaprilSolute carrier family 15 member 1transporter
CilazaprilSolute carrier family 15 member 2transporter
SpiraprilAngiotensin-converting enzymetarget
SpiraprilSolute carrier family 15 member 1transporter
SpiraprilSolute carrier family 15 member 2transporter
TasosartanType-1 angiotensin II receptortarget
TasosartanType-2 angiotensin II receptortarget
TasosartanCytochrome P450 3A4enzyme
Azilsartan medoxomilType-1 angiotensin II receptortarget
TemocaprilSolute carrier family 15 member 1transporter
TemocaprilSolute carrier organic anion transporter family member 1A2transporter
TemocaprilAngiotensin-converting enzymetarget
AliskirenRenintarget
AliskirenCytochrome P450 3A4enzyme
AliskirenP-glycoprotein 1transporter
FimasartanType-1 angiotensin II receptortarget
FimasartanSolute carrier organic anion transporter family member 1B1transporter
FimasartanATP-binding cassette sub-family G member 2transporter
ZofenoprilAngiotensin-converting enzymetarget
CandesartanType-1 angiotensin II receptortarget
CandesartanCytochrome P450 2C8enzyme
CandesartanCytochrome P450 2C9enzyme
CandesartanP-glycoprotein 1transporter
CandesartanUDP-glucuronosyltransferase 1-3enzyme
CandesartanProstaglandin G/H synthase 1enzyme
CandesartanSolute carrier organic anion transporter family member 1B1transporter
SaprisartanType-1 angiotensin II receptortarget
ForasartanType-1 angiotensin II receptortarget
EnalaprilatAngiotensin-converting enzymetarget
EnalaprilatB1 bradykinin receptortarget
OmapatrilatNeprilysintarget
OmapatrilatAngiotensin-converting enzymetarget
RescinnamineAngiotensin-converting enzymetarget
EnalkirenRenintarget
CilazaprilatAngiotensin-converting enzymetarget
N-(2-Aminoethyl)-1-aziridineethanamineAngiotensin-converting enzyme 2target