Drugs Used in Addictive Disorders

DrugDrug NameDrug Description
DB00184NicotineA stimulatory alkaloid found in tobacco products that is often used for the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.
DB00659AcamprosateA medication used to maintain alcohol abstinence in patients with alcohol dependence.
DB00704NaltrexoneA narcotic antagonist used in opioid overdose.
DB00921BuprenorphineA partial opioid agonist used for management of severe pain that is not responsive to alternative treatments. Also used for maintenance treatment of opioid addiction.
DB01227LevacetylmethadolFor the treatment and management of opiate dependence. It is sometimes used to treat severe pain in terminal patients.
DB01273VareniclineA partial agonist at nicotinic acetylcholine receptors used as an aid in smoking cessation.
DB01452DiamorphineAn opioid analgesic agent used in the relief of severe pain associated with surgical procedures, myocardial infarction or pain in the terminally ill and for the relief of dyspnea in acute pulmonary edema.
DB04948LofexidineA centrally acting alpha2-adrenergic agonist used for the symptomatic treatment of acute opioid withdrawal syndrome to facilitate abrupt opioid discontinuation in adults.
DB06230NalmefeneAn opioid antagonist used in conjunction with psychosocial support to help adults with alcohol dependence reduce alcohol consumption.
DB09116Calcium carbimideCalcium carbimide has not been approved by the FDA but the intended indication is for the treatment of alcoholism. This medication was marketed in Canada, United Kingdom and Europe under...
DB13515LevomethadoneNot Annotated
DB00333MethadoneAn opioid analgesic indicated for management of severe pain that is not responsive to alternative treatments. Also used to aid in detoxification and maintenance treatment of opioid addiction.
DB00822DisulfiramA carbamate derivative used to treat alcohol addiction.
DB09028CytisineIndicated for use in smoking cessation.
DrugDrug NameTargetType
DB00184NicotineNeuronal acetylcholine receptor subunit alpha-2target
DB00184NicotineNeuronal acetylcholine receptor subunit beta-2target
DB00184NicotineNeuronal acetylcholine receptor subunit alpha-7target
DB00184NicotineNeuronal acetylcholine receptor subunit alpha-4target
DB00184NicotineNeuronal acetylcholine receptor subunit alpha-10target
DB00184NicotineNeuronal acetylcholine receptor subunit alpha-9target
DB00184NicotineCytochrome P450 2A6enzyme
DB00184NicotineCytochrome P450 2E1enzyme
DB00184NicotineCytochrome P450 2A13enzyme
DB00184NicotineCytochrome P450 2B6enzyme
DB00184NicotineNeuronal acetylcholine receptor subunit beta-4target
DB00184NicotineNeuronal acetylcholine receptor subunit alpha-3target
DB00184NicotineNeuronal acetylcholine receptor subunit alpha-5target
DB00184NicotineNeuronal acetylcholine receptor subunit alpha-6target
DB00184NicotineNeuronal acetylcholine receptor subunit beta-3target
DB00184NicotineSolute carrier family 22 member 2transporter
DB00184NicotineSolute carrier family 22 member 1transporter
DB00184NicotineSolute carrier family 22 member 3transporter
DB00184NicotineSolute carrier family 22 member 5transporter
DB00184NicotineSolute carrier family 22 member 4transporter
DB00184NicotineCytochrome P450 1A1enzyme
DB00184NicotineCytochrome P450 1A2enzyme
DB00184NicotineCytochrome P450 2C19enzyme
DB00184NicotineCytochrome P450 2C8enzyme
DB00184NicotineCytochrome P450 2C9enzyme
DB00184NicotineCytochrome P450 2D6enzyme
DB00184NicotineCytochrome P450 3A4enzyme
DB00184NicotineAmine oxidase [flavin-containing] Aenzyme
DB00184NicotineAmine oxidase [flavin-containing] Benzyme
DB00184NicotineCytochrome P450 19A1target
DB00184NicotineCholine O-acetyltransferasetarget
DB00659AcamprosateMetabotropic glutamate receptor 5target
DB00659AcamprosateProton-coupled amino acid transporter 1transporter
DB00659AcamprosateGABA-A receptor (anion channel)target
DB00659AcamprosateGlutamate (NMDA) receptortarget
DB00704NaltrexoneMu-type opioid receptortarget
DB00704NaltrexoneKappa-type opioid receptortarget
DB00704NaltrexoneDelta-type opioid receptortarget
DB00704NaltrexoneHCG20471, isoform CRA_ctarget
DB00704NaltrexoneUDP-glucuronosyltransferase 1-1enzyme
DB00921BuprenorphineKappa-type opioid receptortarget
DB00921BuprenorphineMu-type opioid receptortarget
DB00921BuprenorphineCytochrome P450 3A4enzyme
DB00921BuprenorphineCytochrome P450 2D6enzyme
DB00921BuprenorphineP-glycoprotein 1transporter
DB00921BuprenorphineATP-binding cassette sub-family G member 2transporter
DB00921BuprenorphineCytochrome P450 2C9enzyme
DB00921BuprenorphineCytochrome P450 3A5enzyme
DB00921BuprenorphineCytochrome P450 2C8enzyme
DB00921BuprenorphineCytochrome P450 3A7enzyme
DB00921BuprenorphineDelta-type opioid receptortarget
DB00921BuprenorphineCytochrome P450 2C18enzyme
DB00921BuprenorphineCytochrome P450 2C19enzyme
DB00921BuprenorphineNociceptin receptortarget
DB01227LevacetylmethadolMu-type opioid receptortarget
DB01227LevacetylmethadolCytochrome P450 3A4enzyme
DB01227LevacetylmethadolNeuronal acetylcholine receptor subunit beta-4target
DB01227LevacetylmethadolNeuronal acetylcholine receptor subunit alpha-3target
DB01227LevacetylmethadolCytochrome P450 3A5enzyme
DB01227LevacetylmethadolCytochrome P450 3A7enzyme
DB01273VareniclineNeuronal acetylcholine receptor subunit alpha-4target
DB01273VareniclineNeuronal acetylcholine receptor subunit alpha-7target
DB01273VareniclineNeuronal acetylcholine receptor subunit alpha-3target
DB01273VareniclineNeuronal acetylcholine receptor subunit alpha-6target
DB01273VareniclineNeuronal acetylcholine receptor subunit beta-2target
DB01273VareniclineSolute carrier family 22 member 2transporter
DB01452DiamorphineMu-type opioid receptortarget
DB01452DiamorphineKappa-type opioid receptortarget
DB01452DiamorphineDelta-type opioid receptortarget
DB01452DiamorphineLiver carboxylesterase 1target
DB01452DiamorphineThyroxine-binding globulincarrier
DB04948LofexidineAlpha-2A adrenergic receptortarget
DB04948LofexidineAlpha-1A adrenergic receptortarget
DB04948Lofexidine5-hydroxytryptamine receptor 1Atarget
DB04948Lofexidine5-hydroxytryptamine receptor 7target
DB04948Lofexidine5-hydroxytryptamine receptor 2Ctarget
DB04948Lofexidine5-hydroxytryptamine receptor 1Dtarget
DB04948LofexidineCytochrome P450 2D6enzyme
DB04948LofexidineCytochrome P450 1A2enzyme
DB04948LofexidineCytochrome P450 2C19enzyme
DB04948LofexidineATP-binding cassette sub-family B member 5transporter
DB04948LofexidineMultidrug and toxin extrusion protein 1transporter
DB06230NalmefeneMu-type opioid receptortarget
DB06230NalmefeneKappa-type opioid receptortarget
DB06230NalmefeneDelta-type opioid receptortarget
DB06230NalmefeneUDP-glucuronosyltransferase 2B7enzyme
DB06230NalmefeneUDP-glucuronosyltransferase 1-3enzyme
DB06230NalmefeneUDP-glucuronosyltransferase 1-8enzyme
DB09116Calcium carbimideAldehyde dehydrogenase family 3 member B2target
DB09116Calcium carbimideCatalaseenzyme
DB00333MethadoneNMDA receptortarget
DB00333MethadoneMu-type opioid receptortarget
DB00333MethadoneCytochrome P450 2B6enzyme
DB00333MethadoneCytochrome P450 3A4enzyme
DB00333MethadoneCytochrome P450 2C19enzyme
DB00333MethadoneDelta-type opioid receptortarget
DB00333MethadoneCytochrome P450 3A7enzyme
DB00333MethadoneCytochrome P450 2D6enzyme
DB00333MethadoneP-glycoprotein 1transporter
DB00333MethadoneCytochrome P450 2C8enzyme
DB00333MethadoneCytochrome P450 19A1enzyme
DB00333MethadoneCytochrome P450 1A2enzyme
DB00333MethadoneCytochrome P450 2C18enzyme
DB00333MethadoneCytochrome P450 2C9enzyme
DB00333Methadone5-hydroxytryptamine receptor 3Atarget
DB00333MethadoneAlpha-1-acid glycoprotein 1carrier
DB00333MethadoneSerum albumincarrier
DB00333MethadoneNeuronal acetylcholine receptor subunit alpha-7target
DB00333MethadoneNeuronal acetylcholine receptor subunit alpha-3target
DB00333MethadoneNeuronal acetylcholine receptor subunit alpha-4target
DB00333MethadoneNeuronal acetylcholine receptor subunit beta-2target
DB00822DisulfiramAldehyde dehydrogenase, mitochondrialtarget
DB00822DisulfiramCytochrome P450 2E1enzyme
DB00822DisulfiramDopamine beta-hydroxylasetarget
DB00822DisulfiramCytochrome P450 3A4enzyme
DB00822DisulfiramCytochrome P450 3A5enzyme
DB00822DisulfiramBile salt export pumptransporter
DB09028CytisineNeuronal acetylcholine receptor subunit alpha-4target
DB09028CytisineNeuronal acetylcholine receptor subunit alpha-7target
DB09028CytisineNeuronal acetylcholine receptor subunit alpha-3target
DB09028CytisineNeuronal acetylcholine receptor subunit alpha-6target
DB09028CytisineNeuronal acetylcholine receptor subunit beta-2target