Drugs Used in Addictive Disorders

DrugDrug NameDrug Indication
DB00184NicotineFor the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.
DB00659AcamprosateFor the maintenance of abstinence from alcohol in patients with alcohol dependence who are abstinent at treatment initiation
DB00704NaltrexoneUsed as an adjunct to a medically supervised behaviour modification program in the maintenance of opiate cessation in individuals who were formerly physically dependent on opiates and who have successfully undergone detoxification. Also used for the management of alcohol dependence in conjunction with a behavioural modification program.
DB00921BuprenorphineFor the treatment of moderate to severe pain, peri-operative analgesia, and opioid dependence.
DB01227Levomethadyl acetateFor the treatment and management of opiate dependence. It is sometimes used to treat severe pain in terminal patients.
DB01273VareniclineFor use as an aid in smoking cessation.
DB01452HeroinUsed in the treatment of acute pain, myocardial infarction, acute pulmonary oedema, and chronic pain.
DB04948LofexidineLofexidine is indicated for mitigation of symptoms associated with acute withdrawal from opioids and for facilitation of the completion of opioid discontinuation treatment. It is the first non-opioid medication for the symptomatic management of opioid discontinuation.[L2801] Opioid withdrawal syndrome is a debilitating manifestation of opioid dependence.[A33085] This condition is extremely unpleasant lasting several days with some of the main features being abdominal pain, nausea, diarrhea, mydriasis, lacrimation, and piloerection. These symptoms are often observed after abrupt reductions in the opioid dose and can be resolved by re-administration of the opioid.[A33088]
DB06230NalmefeneIndicated for the reduction of alcohol consumption in adult patients with alcohol dependence who have a high drinking risk level (DRL), without physical withdrawal symptoms and who do not require immediate detoxification [L1024]. Indicated for the complete or partial reversal of opioid drug effects, including respiratory depression - induced by either natural or synthetic opioids - or in the management of known or suspected opioid overdose [FDA Label].
DB09116Calcium carbimideCalcium carbimide has not been approved by the FDA but the intended indication is for the treatment of alcoholism.[T74] This medication was marketed in Canada, United Kingdom and Europe under the trade name of Temposil for the sole use of alcoholism treatment.[L1114]
DB00333MethadoneFor the treatment of dry cough, drug withdrawal syndrome, opioid type drug dependence, and pain.
DB00822DisulfiramFor the treatment and management of chronic alcoholism
DrugDrug NameTargetType
DB00184NicotineCytochrome P450 2A6enzyme
DB00184NicotineCytochrome P450 2E1enzyme
DB00184NicotineCytochrome P450 2A13enzyme
DB00184NicotineCytochrome P450 2B6enzyme
DB00184NicotineCytochrome P450 1A1enzyme
DB00184NicotineCytochrome P450 1A2enzyme
DB00184NicotineCytochrome P450 2C19enzyme
DB00184NicotineCytochrome P450 2C8enzyme
DB00184NicotineCytochrome P450 2C9enzyme
DB00184NicotineCytochrome P450 2D6enzyme
DB00184NicotineCytochrome P450 3A4enzyme
DB00184NicotineAmine oxidase [flavin-containing] Aenzyme
DB00184NicotineAmine oxidase [flavin-containing] Benzyme
DB00184NicotineNeuronal acetylcholine receptor subunit alpha-2target
DB00184NicotineNeuronal acetylcholine receptor subunit beta-2target
DB00184NicotineNeuronal acetylcholine receptor subunit alpha-7target
DB00184NicotineNeuronal acetylcholine receptor subunit alpha-4target
DB00184NicotineNeuronal acetylcholine receptor subunit alpha-10target
DB00184NicotineNeuronal acetylcholine receptor subunit alpha-9target
DB00184NicotineNeuronal acetylcholine receptor subunit beta-4target
DB00184NicotineNeuronal acetylcholine receptor subunit alpha-3target
DB00184NicotineNeuronal acetylcholine receptor subunit alpha-5target
DB00184NicotineNeuronal acetylcholine receptor subunit alpha-6target
DB00184NicotineNeuronal acetylcholine receptor subunit beta-3target
DB00184NicotineCytochrome P450 19A1target
DB00184NicotineCholine O-acetyltransferasetarget
DB00184NicotineSolute carrier family 22 member 2transporter
DB00184NicotineSolute carrier family 22 member 1transporter
DB00184NicotineSolute carrier family 22 member 3transporter
DB00184NicotineSolute carrier family 22 member 5transporter
DB00184NicotineSolute carrier family 22 member 4transporter
DB00659AcamprosateMetabotropic glutamate receptor 5target
DB00659AcamprosateGABA-A receptor (anion channel)target
DB00659AcamprosateGlutamate (NMDA) receptortarget
DB00659AcamprosateProton-coupled amino acid transporter 1transporter
DB00704NaltrexoneUDP-glucuronosyltransferase 1-1enzyme
DB00704NaltrexoneMu-type opioid receptortarget
DB00704NaltrexoneKappa-type opioid receptortarget
DB00704NaltrexoneDelta-type opioid receptortarget
DB00704NaltrexoneHCG20471, isoform CRA_ctarget
DB00921BuprenorphineCytochrome P450 3A4enzyme
DB00921BuprenorphineCytochrome P450 2D6enzyme
DB00921BuprenorphineCytochrome P450 2C9enzyme
DB00921BuprenorphineCytochrome P450 3A5enzyme
DB00921BuprenorphineCytochrome P450 2C8enzyme
DB00921BuprenorphineCytochrome P450 3A7enzyme
DB00921BuprenorphineUDP-glucuronosyltransferase 1-9enzyme
DB00921BuprenorphineCytochrome P450 2A6enzyme
DB00921BuprenorphineCytochrome P450 2C18enzyme
DB00921BuprenorphineCytochrome P450 2C19enzyme
DB00921BuprenorphineUDP-glucuronosyltransferase 1-1enzyme
DB00921BuprenorphineKappa-type opioid receptortarget
DB00921BuprenorphineMu-type opioid receptortarget
DB00921BuprenorphineDelta-type opioid receptortarget
DB00921BuprenorphineNociceptin receptortarget
DB00921BuprenorphineMultidrug resistance protein 1transporter
DB00921BuprenorphineATP-binding cassette sub-family G member 2transporter
DB01227Levomethadyl acetateCytochrome P450 3A4enzyme
DB01227Levomethadyl acetateCytochrome P450 3A5enzyme
DB01227Levomethadyl acetateCytochrome P450 3A7enzyme
DB01227Levomethadyl acetateCytochrome P450 19A1enzyme
DB01227Levomethadyl acetateMu-type opioid receptortarget
DB01227Levomethadyl acetateNeuronal acetylcholine receptor subunit beta-4target
DB01227Levomethadyl acetateNeuronal acetylcholine receptor subunit alpha-3target
DB01273VareniclineNeuronal acetylcholine receptor subunit alpha-4target
DB01273VareniclineNeuronal acetylcholine receptor subunit alpha-7target
DB01273VareniclineNeuronal acetylcholine receptor subunit alpha-3target
DB01273VareniclineNeuronal acetylcholine receptor subunit alpha-6target
DB01273VareniclineNeuronal acetylcholine receptor subunit beta-2target
DB01273VareniclineSolute carrier family 22 member 2transporter
DB01452HeroinMu-type opioid receptortarget
DB01452HeroinKappa-type opioid receptortarget
DB01452HeroinDelta-type opioid receptortarget
DB01452HeroinLiver carboxylesterase 1target
DB04948LofexidineCytochrome P450 2D6enzyme
DB04948LofexidineCytochrome P450 1A2enzyme
DB04948LofexidineCytochrome P450 2C19enzyme
DB04948LofexidineAlpha-2A adrenergic receptortarget
DB04948LofexidineAlpha-1A adrenergic receptortarget
DB04948Lofexidine5-hydroxytryptamine receptor 1Atarget
DB04948Lofexidine5-hydroxytryptamine receptor 7target
DB04948Lofexidine5-hydroxytryptamine receptor 2Ctarget
DB04948Lofexidine5-hydroxytryptamine receptor 1Dtarget
DB04948LofexidineATP-binding cassette sub-family B member 5transporter
DB04948LofexidineMultidrug and toxin extrusion protein 1transporter
DB06230NalmefeneUDP-glucuronosyltransferase 2B7enzyme
DB06230NalmefeneUDP-glucuronosyltransferase 1-3enzyme
DB06230NalmefeneUDP-glucuronosyltransferase 1-8enzyme
DB06230NalmefeneMu-type opioid receptortarget
DB06230NalmefeneKappa-type opioid receptortarget
DB06230NalmefeneDelta-type opioid receptortarget
DB09116Calcium carbimideCatalaseenzyme
DB09116Calcium carbimideAldehyde dehydrogenase family 3 member B2target
DB00333MethadoneCytochrome P450 2B6enzyme
DB00333MethadoneCytochrome P450 3A4enzyme
DB00333MethadoneCytochrome P450 2C19enzyme
DB00333MethadoneCytochrome P450 3A5enzyme
DB00333MethadoneCytochrome P450 3A7enzyme
DB00333MethadoneCytochrome P450 2D6enzyme
DB00333MethadoneCytochrome P450 2C8enzyme
DB00333MethadoneCytochrome P450 19A1enzyme
DB00333MethadoneCytochrome P450 1A2enzyme
DB00333MethadoneCytochrome P450 2C18enzyme
DB00333MethadoneCytochrome P450 2C9enzyme
DB00333MethadoneGlutamate receptor ionotropic, NMDA 3Atarget
DB00333MethadoneMu-type opioid receptortarget
DB00333MethadoneNeuronal acetylcholine receptor subunit alpha-10target
DB00333MethadoneDelta-type opioid receptortarget
DB00333Methadone5-hydroxytryptamine receptor 3Atarget
DB00333MethadoneLymphocyte antigen 96target
DB00333MethadoneAlpha-1-acid glycoprotein 2target
DB00333MethadoneMultidrug resistance protein 1transporter
DB00822DisulfiramCytochrome P450 2E1enzyme
DB00822DisulfiramCytochrome P450 3A4enzyme
DB00822DisulfiramCytochrome P450 3A5enzyme
DB00822DisulfiramAldehyde dehydrogenase, mitochondrialtarget
DB00822DisulfiramDopamine beta-hydroxylasetarget
DB00822DisulfiramBile salt export pumptransporter