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Identification
NameHeroin
Accession NumberDB01452
TypeSmall Molecule
GroupsApproved, Illicit
DescriptionA narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed) Internationally, heroin is controlled under Schedules I and IV of the Single Convention on Narcotic Drugs. It is illegal to manufacture, possess, or sell heroin in the United States and the UK. However, under the name diamorphine, heroin is a legal prescription drug in the United Kingdom.
Structure
Thumb
Synonyms
(5α,6α)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol diacetate (ester)
3,6-Diacetylmorphine
7,8-Dihydro-4,5-alpha-epoxy-17-methylmorphinan-3,6-alpha-diol diacetate
Diacetylmorphine
Diamorphine
O,O'-Diacetylmorphine
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Heroin hydrochloride
Thumb
  • InChI Key: FZJYQGFGNHGSFX-PVQKIFDLSA-N
  • Monoisotopic Mass: 405.13430059
  • Average Mass: 405.872
DBSALT000095
Categories
UNII70D95007SX
CAS number561-27-3
WeightAverage: 369.411
Monoisotopic: 369.157622851
Chemical FormulaC21H23NO5
InChI KeyGVGLGOZIDCSQPN-PVHGPHFFSA-N
InChI
InChI=1S/C21H23NO5/c1-11(23)25-16-6-4-13-10-15-14-5-7-17(26-12(2)24)20-21(14,8-9-22(15)3)18(13)19(16)27-20/h4-7,14-15,17,20H,8-10H2,1-3H3/t14-,15+,17-,20-,21-/m0/s1
IUPAC Name
(1S,5R,13R,14S,17R)-14-(acetyloxy)-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7(18),8,10,15-tetraen-10-yl acetate
SMILES
[H][C@@]12OC3=C(OC(C)=O)C=CC4=C3[C@@]11CCN(C)[C@]([H])(C4)[C@]1([H])C=C[C@@H]2OC(C)=O
Pharmacology
IndicationUsed in the treatment of acute pain, myocardial infarction, acute pulmonary oedema, and chronic pain.
Structured Indications Not Available
PharmacodynamicsThe onset of heroin's effects is dependent on the method of administration. Taken orally, heroin is totally metabolized in vivo into morphine before crossing the blood-brain barrier; so the effects are the same as oral morphine. Take by injection, heroin crosses into the brain. Once in the brain, heroin is rapidly metabolized into morphine by removal of the acetyl groups, therefore, it is known as a prodrug. It is the morphine molecule that then binds with opioid receptors and produces the subjective effects of the heroin high.
Mechanism of actionHeroin is a mu-opioid agonist. It acts on endogenous mu-opioid receptors that are spread in discrete packets throughout the brain, spinal cord and gut in almost all mammals. Heroin, along with other opioids, are agonists to four endogenous neurotransmitters. They are beta-endorphin, dynorphin, leu-enkephalin, and met-enkephalin. The body responds to heroin in the brain by reducing (and sometimes stopping) production of the endogenous opioids when heroin is present. Endorphins are regularly released in the brain and nerves, attenuating pain. Their other functions are still obscure, but are probably related to the effects produced by heroin besides analgesia (antitussin, anti-diarrheal).
TargetKindPharmacological actionActionsOrganismUniProt ID
Mu-type opioid receptorProteinyes
agonist
HumanP35372 details
Kappa-type opioid receptorProteinunknown
agonist
HumanP41145 details
Delta-type opioid receptorProteinunknown
agonist
HumanP41143 details
Related Articles
AbsorptionBioavailability is less than 35%.
Volume of distributionNot Available
Protein binding0% (morphine metabolite 35%)
Metabolism

Hepatic.

SubstrateEnzymesProduct
Heroin
6-MonoacetylmorphineDetails
6-Monoacetylmorphine
morphineDetails
Heroin
morphineDetails
Route of elimination90% renal as glucuronides, rest biliary
Half life<10 minutes
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Heroin Action PathwayDrug actionSMP00407
Heroin Metabolism PathwayDrug metabolismSMP00623
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,1,1,2 TetrafluoroethaneThe risk or severity of adverse effects can be increased when Heroin is combined with 1,1,1,2 Tetrafluoroethane.Investigational
2,5-Dimethoxy-4-ethylamphetamine2,5-Dimethoxy-4-ethylamphetamine may increase the analgesic activities of Heroin.Experimental, Illicit
3,4-Methylenedioxyamphetamine3,4-Methylenedioxyamphetamine may increase the analgesic activities of Heroin.Experimental, Illicit
3,4-Methylenedioxymethamphetamine3,4-Methylenedioxymethamphetamine may increase the analgesic activities of Heroin.Experimental, Illicit
4-Bromo-2,5-dimethoxyamphetamine4-Bromo-2,5-dimethoxyamphetamine may increase the analgesic activities of Heroin.Experimental, Illicit
7-NitroindazoleThe risk or severity of adverse effects can be increased when Heroin is combined with 7-Nitroindazole.Experimental
AcepromazineThe risk or severity of adverse effects can be increased when Heroin is combined with Acepromazine.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Heroin is combined with Aceprometazine.Approved
AcetazolamideThe risk or severity of adverse effects can be increased when Heroin is combined with Acetazolamide.Approved, Vet Approved
AclidiniumThe risk or severity of adverse effects can be increased when Aclidinium is combined with Heroin.Approved
adipiplonThe risk or severity of adverse effects can be increased when Heroin is combined with adipiplon.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Heroin is combined with Agomelatine.Approved, Investigational
AlfaxaloneThe risk or severity of adverse effects can be increased when Heroin is combined with Alfaxalone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Heroin.Approved, Illicit
AlimemazineAlimemazine may increase the hypotensive activities of Heroin.Approved, Vet Approved
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Heroin is combined with Alphacetylmethadol.Experimental, Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Heroin.Approved, Illicit, Investigational
AlvimopanThe risk or severity of adverse effects can be increased when Heroin is combined with Alvimopan.Approved
AmilorideThe risk or severity of adverse effects can be increased when Heroin is combined with Amiloride.Approved
AmisulprideThe risk or severity of adverse effects can be increased when Heroin is combined with Amisulpride.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Heroin is combined with Amitriptyline.Approved
Ammonium chlorideAmmonium chloride may increase the excretion rate of Heroin which could result in a lower serum level and potentially a reduction in efficacy.Approved, Vet Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Heroin.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Heroin is combined with Amoxapine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Heroin is combined with Amperozide.Experimental
AmphetamineAmphetamine may increase the analgesic activities of Heroin.Approved, Illicit
Anisotropine MethylbromideThe risk or severity of adverse effects can be increased when Anisotropine Methylbromide is combined with Heroin.Approved
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Heroin.Approved, Investigational
ArticaineThe risk or severity of adverse effects can be increased when Heroin is combined with Articaine.Approved
AsenapineThe risk or severity of adverse effects can be increased when Heroin is combined with Asenapine.Approved
Atracurium besylateThe risk or severity of adverse effects can be increased when Atracurium besylate is combined with Heroin.Approved
AtropineThe risk or severity of adverse effects can be increased when Atropine is combined with Heroin.Approved, Vet Approved
AzaperoneThe risk or severity of adverse effects can be increased when Heroin is combined with Azaperone.Vet Approved
AzelastineHeroin may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
AzelastineThe risk or severity of adverse effects can be increased when Heroin is combined with Azelastine.Approved
AzosemideThe risk or severity of adverse effects can be increased when Heroin is combined with Azosemide.Investigational
BaclofenThe risk or severity of adverse effects can be increased when Heroin is combined with Baclofen.Approved
BarbitalThe risk or severity of adverse effects can be increased when Heroin is combined with Barbital.Illicit
BenactyzineThe risk or severity of adverse effects can be increased when Benactyzine is combined with Heroin.Withdrawn
BendroflumethiazideThe risk or severity of adverse effects can be increased when Heroin is combined with Bendroflumethiazide.Approved
BenperidolThe risk or severity of adverse effects can be increased when Heroin is combined with Benperidol.Investigational
BenzatropineThe risk or severity of adverse effects can be increased when Benzatropine is combined with Heroin.Approved
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Heroin.Approved
BenzphetamineBenzphetamine may increase the analgesic activities of Heroin.Approved, Illicit
Benzyl alcoholThe risk or severity of adverse effects can be increased when Heroin is combined with Benzyl alcohol.Approved
BiperidenThe risk or severity of adverse effects can be increased when Biperiden is combined with Heroin.Approved
BL-1020BL-1020 may increase the hypotensive activities of Heroin.Investigational
BrexpiprazoleThe risk or severity of adverse effects can be increased when Heroin is combined with Brexpiprazole.Approved
BrimonidineThe risk or severity of adverse effects can be increased when Heroin is combined with Brimonidine.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Heroin.Approved
BromazepamThe risk or severity of adverse effects can be increased when Heroin is combined with Bromazepam.Approved, Illicit
BrompheniramineThe risk or severity of adverse effects can be increased when Heroin is combined with Brompheniramine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Heroin is combined with Brotizolam.Approved, Withdrawn
BumetanideThe risk or severity of adverse effects can be increased when Heroin is combined with Bumetanide.Approved
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Heroin.Approved, Investigational
BuprenorphineHeroin may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Heroin.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Heroin.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Heroin is combined with Butacaine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Heroin is combined with Butalbital.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Heroin is combined with Butamben.Approved
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Heroin.Approved, Illicit
ButorphanolButorphanol may decrease the analgesic activities of Heroin.Approved, Illicit, Vet Approved
Canrenoic acidThe risk or severity of adverse effects can be increased when Heroin is combined with Canrenoic acid.Approved, Withdrawn
CanrenoneThe risk or severity of adverse effects can be increased when Heroin is combined with Canrenone.Investigational
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Heroin.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Heroin is combined with Carbinoxamine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Heroin is combined with Carfentanil.Illicit, Vet Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Heroin is combined with Carisoprodol.Approved
CetirizineThe risk or severity of adverse effects can be increased when Heroin is combined with Cetirizine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Heroin is combined with Chloral hydrate.Approved, Illicit, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Heroin.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Heroin.Approved, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Heroin.Approved
ChlorothiazideThe risk or severity of adverse effects can be increased when Heroin is combined with Chlorothiazide.Approved, Vet Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Heroin is combined with Chlorphenamine.Approved
ChlorphenoxamineThe risk or severity of adverse effects can be increased when Chlorphenoxamine is combined with Heroin.Withdrawn
ChlorphentermineChlorphentermine may increase the analgesic activities of Heroin.Illicit, Withdrawn
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Heroin.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Heroin.Approved, Withdrawn
ChlorthalidoneThe risk or severity of adverse effects can be increased when Heroin is combined with Chlorthalidone.Approved
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Heroin is combined with Chlorzoxazone.Approved
CicletanineThe risk or severity of adverse effects can be increased when Heroin is combined with Cicletanine.Investigational
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Heroin.Approved, Vet Approved
CitalopramHeroin may increase the serotonergic activities of Citalopram.Approved
ClemastineThe risk or severity of adverse effects can be increased when Heroin is combined with Clemastine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Heroin is combined with Clidinium.Approved
ClobazamThe risk or severity of adverse effects can be increased when Heroin is combined with Clobazam.Approved, Illicit
clomethiazoleThe risk or severity of adverse effects can be increased when Heroin is combined with clomethiazole.Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Heroin is combined with Clomipramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Heroin is combined with Clonazepam.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Heroin is combined with Clonidine.Approved
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Heroin.Approved, Illicit
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Heroin.Approved
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Heroin.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Heroin.Approved, Illicit
ConivaptanThe risk or severity of adverse effects can be increased when Heroin is combined with Conivaptan.Approved, Investigational
CyclizineThe risk or severity of adverse effects can be increased when Heroin is combined with Cyclizine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Heroin.Approved
CyclopentolateThe risk or severity of adverse effects can be increased when Cyclopentolate is combined with Heroin.Approved
CyclothiazideThe risk or severity of adverse effects can be increased when Heroin is combined with Cyclothiazide.Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Heroin is combined with Cyproheptadine.Approved
DantroleneThe risk or severity of adverse effects can be increased when Heroin is combined with Dantrolene.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Heroin.Approved
DapoxetineHeroin may increase the serotonergic activities of Dapoxetine.Investigational
DarifenacinThe risk or severity of adverse effects can be increased when Darifenacin is combined with Heroin.Approved, Investigational
deramciclaneThe risk or severity of adverse effects can be increased when Heroin is combined with deramciclane.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Heroin.Approved
DesipramineThe risk or severity of adverse effects can be increased when Heroin is combined with Desipramine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Heroin is combined with Desloratadine.Approved, Investigational
DesmopressinThe risk or severity of adverse effects can be increased when Heroin is combined with Desmopressin.Approved
DesvenlafaxineHeroin may increase the serotonergic activities of Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Heroin is combined with Detomidine.Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Heroin is combined with Dexbrompheniramine.Approved
DexetimideThe risk or severity of adverse effects can be increased when Dexetimide is combined with Heroin.Withdrawn
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Heroin.Approved, Vet Approved
DextroamphetamineDextroamphetamine may increase the analgesic activities of Heroin.Approved, Illicit
DextromoramideThe risk or severity of adverse effects can be increased when Heroin is combined with Dextromoramide.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Heroin.Approved, Illicit, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Heroin.Approved
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Heroin.Approved, Illicit, Vet Approved
DicyclomineThe risk or severity of adverse effects can be increased when Dicyclomine is combined with Heroin.Approved
DiethylpropionDiethylpropion may increase the analgesic activities of Heroin.Approved, Illicit
DifenoxinThe risk or severity of adverse effects can be increased when Heroin is combined with Difenoxin.Approved, Illicit
DihydrocodeineThe risk or severity of adverse effects can be increased when Heroin is combined with Dihydrocodeine.Approved, Illicit
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Heroin.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Heroin is combined with Dihydromorphine.Experimental, Illicit
DimenhydrinateThe risk or severity of adverse effects can be increased when Heroin is combined with Dimenhydrinate.Approved
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Heroin.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Heroin.Approved, Illicit
DoramectinThe risk or severity of adverse effects can be increased when Heroin is combined with Doramectin.Vet Approved
DoxepinThe risk or severity of adverse effects can be increased when Heroin is combined with Doxepin.Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Heroin.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when Heroin is combined with DPDPE.Investigational
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Heroin.Approved, Illicit
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Heroin.Approved, Vet Approved
DrospirenoneThe risk or severity of adverse effects can be increased when Heroin is combined with Drospirenone.Approved
DrotebanolThe risk or severity of adverse effects can be increased when Heroin is combined with Drotebanol.Experimental, Illicit
DuloxetineHeroin may increase the serotonergic activities of Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Heroin.Approved
EcgonineThe risk or severity of adverse effects can be increased when Heroin is combined with Ecgonine.Experimental, Illicit
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when Heroin is combined with ECGONINE METHYL ESTER.Experimental
EcopipamThe risk or severity of adverse effects can be increased when Heroin is combined with Ecopipam.Investigational
EfavirenzThe risk or severity of adverse effects can be increased when Heroin is combined with Efavirenz.Approved, Investigational
EfonidipineThe risk or severity of adverse effects can be increased when Heroin is combined with Efonidipine.Approved
EluxadolineHeroin may increase the constipating activities of Eluxadoline.Approved
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Heroin.Approved, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Heroin is combined with Entacapone.Approved, Investigational
EplerenoneThe risk or severity of adverse effects can be increased when Heroin is combined with Eplerenone.Approved
EscitalopramHeroin may increase the serotonergic activities of Escitalopram.Approved, Investigational
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Heroin.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Heroin.Approved
Etacrynic acidThe risk or severity of adverse effects can be increased when Heroin is combined with Etacrynic acid.Approved
EthanolHeroin may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Heroin.Approved, Illicit, Withdrawn
EthopropazineThe risk or severity of adverse effects can be increased when Ethopropazine is combined with Heroin.Approved
EthosuximideThe risk or severity of adverse effects can be increased when Heroin is combined with Ethosuximide.Approved
EthotoinThe risk or severity of adverse effects can be increased when Heroin is combined with Ethotoin.Approved
EthoxzolamideThe risk or severity of adverse effects can be increased when Heroin is combined with Ethoxzolamide.Withdrawn
Ethyl carbamateThe risk or severity of adverse effects can be increased when Heroin is combined with Ethyl carbamate.Withdrawn
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Heroin is combined with Ethyl loflazepate.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Heroin is combined with Ethylmorphine.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Heroin is combined with Etidocaine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Heroin is combined with Etifoxine.Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Heroin is combined with Etizolam.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Heroin.Approved
EtoperidoneHeroin may increase the serotonergic activities of Etoperidone.Approved
EtorphineThe risk or severity of adverse effects can be increased when Heroin is combined with Etorphine.Illicit, Vet Approved
EzogabineThe risk or severity of adverse effects can be increased when Heroin is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Heroin is combined with Felbamate.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Heroin is combined with Fencamfamine.Approved, Illicit, Withdrawn
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Heroin.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe risk or severity of adverse effects can be increased when Fesoterodine is combined with Heroin.Approved
FexofenadineThe risk or severity of adverse effects can be increased when Heroin is combined with Fexofenadine.Approved
FlibanserinThe risk or severity of adverse effects can be increased when Heroin is combined with Flibanserin.Approved
FludiazepamThe risk or severity of adverse effects can be increased when Heroin is combined with Fludiazepam.Approved, Illicit
FlunarizineThe risk or severity of adverse effects can be increased when Heroin is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Heroin is combined with Flunitrazepam.Approved, Illicit
FluoxetineHeroin may increase the serotonergic activities of Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Heroin.Approved, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Heroin.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Heroin.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Heroin is combined with Fluspirilene.Approved
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Heroin is combined with Fluticasone Propionate.Approved
FluvoxamineThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Heroin.Approved, Investigational
FosphenytoinThe risk or severity of adverse effects can be increased when Heroin is combined with Fosphenytoin.Approved
FospropofolThe risk or severity of adverse effects can be increased when Heroin is combined with Fospropofol.Approved, Illicit
FurosemideThe risk or severity of adverse effects can be increased when Heroin is combined with Furosemide.Approved, Vet Approved
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Heroin.Approved, Investigational
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Heroin is combined with gabapentin enacarbil.Approved
Gallamine TriethiodideThe risk or severity of adverse effects can be increased when Gallamine Triethiodide is combined with Heroin.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Heroin.Approved, Illicit
GepironeThe risk or severity of adverse effects can be increased when Heroin is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Heroin.Approved, Illicit
GlycopyrroniumThe risk or severity of adverse effects can be increased when Glycopyrronium is combined with Heroin.Approved, Investigational, Vet Approved
GuanfacineThe risk or severity of adverse effects can be increased when Heroin is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Heroin.Approved, Illicit, Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Heroin.Approved
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Heroin.Approved, Vet Approved
HexamethoniumThe risk or severity of adverse effects can be increased when Hexamethonium is combined with Heroin.Experimental
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Heroin.Approved
HomatropineThe risk or severity of adverse effects can be increased when Homatropine is combined with Heroin.Approved
HydrochlorothiazideThe risk or severity of adverse effects can be increased when Heroin is combined with Hydrochlorothiazide.Approved, Vet Approved
HydrocodoneHeroin may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydroflumethiazideThe risk or severity of adverse effects can be increased when Heroin is combined with Hydroflumethiazide.Approved
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Heroin.Approved, Illicit
Hydroxyamphetamine hydrobromideHydroxyamphetamine hydrobromide may increase the analgesic activities of Heroin.Approved
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Heroin.Approved
HyoscyamineThe risk or severity of adverse effects can be increased when Hyoscyamine is combined with Heroin.Approved
IloperidoneThe risk or severity of adverse effects can be increased when Heroin is combined with Iloperidone.Approved
ImipramineThe risk or severity of adverse effects can be increased when Heroin is combined with Imipramine.Approved
IndalpineHeroin may increase the serotonergic activities of Indalpine.Investigational, Withdrawn
IndapamideThe risk or severity of adverse effects can be increased when Heroin is combined with Indapamide.Approved
Ipratropium bromideThe risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Heroin.Approved
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Heroin.Approved, Vet Approved
IsosorbideThe risk or severity of adverse effects can be increased when Heroin is combined with Isosorbide.Approved
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Heroin.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Heroin is combined with Ketazolam.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Heroin is combined with Ketobemidone.Approved
KW-3902The risk or severity of adverse effects can be increased when Heroin is combined with KW-3902.Investigational
LamotrigineThe risk or severity of adverse effects can be increased when Heroin is combined with Lamotrigine.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Heroin is combined with Levetiracetam.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Heroin.Approved
LevocabastineThe risk or severity of adverse effects can be increased when Heroin is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Heroin is combined with Levocetirizine.Approved
LevodopaThe risk or severity of adverse effects can be increased when Heroin is combined with Levodopa.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Heroin.Approved
LevomilnacipranHeroin may increase the serotonergic activities of Levomilnacipran.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Heroin.Approved
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Heroin.Approved, Vet Approved
LisdexamfetamineLisdexamfetamine may increase the analgesic activities of Heroin.Approved, Investigational
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Heroin.Approved
LofentanilThe risk or severity of adverse effects can be increased when Heroin is combined with Lofentanil.Illicit
LoratadineThe risk or severity of adverse effects can be increased when Heroin is combined with Loratadine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Heroin.Approved
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Heroin.Approved
Lu AA21004The risk or severity of adverse effects can be increased when Heroin is combined with Lu AA21004.Investigational
LurasidoneThe risk or severity of adverse effects can be increased when Heroin is combined with Lurasidone.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Heroin.Approved, Vet Approved
MannitolThe risk or severity of adverse effects can be increased when Heroin is combined with Mannitol.Approved, Investigational
MaprotilineThe risk or severity of adverse effects can be increased when Heroin is combined with Maprotiline.Approved
MecamylamineThe risk or severity of adverse effects can be increased when Mecamylamine is combined with Heroin.Approved
MeclizineThe risk or severity of adverse effects can be increased when Heroin is combined with Meclizine.Approved
MedetomidineThe risk or severity of adverse effects can be increased when Heroin is combined with Medetomidine.Vet Approved
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Heroin.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Heroin is combined with Melperone.Approved
MephedroneMephedrone may increase the analgesic activities of Heroin.Investigational
MephentermineMephentermine may increase the analgesic activities of Heroin.Approved
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Heroin.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Heroin.Approved, Illicit
MersalylThe risk or severity of adverse effects can be increased when Heroin is combined with Mersalyl.Approved
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Heroin.Approved
MetaxaloneThe risk or severity of adverse effects can be increased when Heroin is combined with Metaxalone.Approved
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Heroin.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Heroin.Approved, Illicit
MethamphetamineMethamphetamine may increase the analgesic activities of Heroin.Approved, Illicit
MethanthelineThe risk or severity of adverse effects can be increased when Methantheline is combined with Heroin.Approved
MethapyrileneThe risk or severity of adverse effects can be increased when Heroin is combined with Methapyrilene.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Heroin is combined with Methaqualone.Illicit, Withdrawn
MethazolamideThe risk or severity of adverse effects can be increased when Heroin is combined with Methazolamide.Approved
MethocarbamolThe risk or severity of adverse effects can be increased when Heroin is combined with Methocarbamol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Heroin.Approved
MethotrimeprazineHeroin may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Heroin.Approved, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Heroin is combined with Methsuximide.Approved
MethyclothiazideThe risk or severity of adverse effects can be increased when Heroin is combined with Methyclothiazide.Approved
Methylene blueMethylene blue may increase the hypotensive activities of Heroin.Investigational
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Heroin.Approved
MetixeneThe risk or severity of adverse effects can be increased when Metixene is combined with Heroin.Approved
MetolazoneThe risk or severity of adverse effects can be increased when Heroin is combined with Metolazone.Approved
MetyrosineHeroin may increase the sedative activities of Metyrosine.Approved
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Heroin.Approved, Illicit
MilnacipranHeroin may increase the serotonergic activities of Milnacipran.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Heroin.Approved, Investigational
MirtazapineHeroin may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MMDAMMDA may increase the analgesic activities of Heroin.Experimental, Illicit
MolindoneThe risk or severity of adverse effects can be increased when Heroin is combined with Molindone.Approved
MoricizineMoricizine may increase the hypotensive activities of Heroin.Approved, Withdrawn
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Heroin.Approved, Investigational
N-butylscopolammonium bromideThe risk or severity of adverse effects can be increased when N-butylscopolammonium bromide is combined with Heroin.Vet Approved
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Heroin.Approved, Investigational
NalbuphineNalbuphine may decrease the analgesic activities of Heroin.Approved
NaltrexoneThe therapeutic efficacy of Heroin can be decreased when used in combination with Naltrexone.Approved, Investigational, Vet Approved
NefazodoneHeroin may increase the serotonergic activities of Nefazodone.Approved, Withdrawn
NitrazepamThe risk or severity of adverse effects can be increased when Heroin is combined with Nitrazepam.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Heroin is combined with Nitrous oxide.Approved, Vet Approved
NormethadoneThe risk or severity of adverse effects can be increased when Heroin is combined with Normethadone.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Heroin is combined with Nortriptyline.Approved
NVA237The risk or severity of adverse effects can be increased when NVA237 is combined with Heroin.Investigational
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Heroin.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Heroin is combined with Olopatadine.Approved
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Heroin.Approved
OpiumThe risk or severity of adverse effects can be increased when Heroin is combined with Opium.Approved, Illicit
OrphenadrineHeroin may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Heroin is combined with Osanetant.Investigational
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Heroin.Approved
OxetacaineThe risk or severity of adverse effects can be increased when Heroin is combined with Oxetacaine.Investigational
OxprenololThe risk or severity of adverse effects can be increased when Heroin is combined with Oxprenolol.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Heroin.Approved
OxybutyninThe risk or severity of adverse effects can be increased when Oxybutynin is combined with Heroin.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Heroin.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Heroin.Approved, Investigational, Vet Approved
OxyphenoniumThe risk or severity of adverse effects can be increased when Oxyphenonium is combined with Heroin.Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Heroin.Approved
PancuroniumThe risk or severity of adverse effects can be increased when Pancuronium is combined with Heroin.Approved
ParaldehydeHeroin may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ParoxetineHeroin may increase the serotonergic activities of Paroxetine.Approved, Investigational
PegvisomantThe therapeutic efficacy of Pegvisomant can be decreased when used in combination with Heroin.Approved
PentazocinePentazocine may decrease the analgesic activities of Heroin.Approved, Vet Approved
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Heroin.Approved, Vet Approved
PentoliniumThe risk or severity of adverse effects can be increased when Pentolinium is combined with Heroin.Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Heroin.Approved
PerazineThe risk or severity of adverse effects can be increased when Heroin is combined with Perazine.Investigational
PerospironeThe risk or severity of adverse effects can be increased when Heroin is combined with Perospirone.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Heroin.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Heroin.Approved
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Heroin.Approved
PhenoxyethanolThe risk or severity of adverse effects can be increased when Heroin is combined with Phenoxyethanol.Approved
PhenterminePhentermine may increase the analgesic activities of Heroin.Approved, Illicit
PhenytoinThe risk or severity of adverse effects can be increased when Heroin is combined with Phenytoin.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Heroin.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Heroin is combined with Pipamperone.Approved
PipecuroniumThe risk or severity of adverse effects can be increased when Pipecuronium is combined with Heroin.Approved
PipotiazineThe risk or severity of adverse effects can be increased when Heroin is combined with Pipotiazine.Approved
PirenzepineThe risk or severity of adverse effects can be increased when Pirenzepine is combined with Heroin.Approved
PiretanideThe risk or severity of adverse effects can be increased when Heroin is combined with Piretanide.Experimental
PiritramideThe risk or severity of adverse effects can be increased when Heroin is combined with Piritramide.Investigational
PizotifenThe risk or severity of adverse effects can be increased when Heroin is combined with Pizotifen.Approved
PolythiazideThe risk or severity of adverse effects can be increased when Heroin is combined with Polythiazide.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Heroin is combined with Pomalidomide.Approved
PotassiumThe risk or severity of adverse effects can be increased when Heroin is combined with Potassium.Approved
Potassium CitrateThe risk or severity of adverse effects can be increased when Heroin is combined with Potassium Citrate.Approved, Vet Approved
PramipexoleHeroin may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Heroin is combined with Pramocaine.Approved
PrazepamThe risk or severity of adverse effects can be increased when Heroin is combined with Prazepam.Approved, Illicit
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Heroin.Approved, Illicit, Investigational
PregnanoloneThe risk or severity of adverse effects can be increased when Heroin is combined with Pregnanolone.Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Heroin.Approved
PrimidoneThe risk or severity of adverse effects can be increased when Heroin is combined with Primidone.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Heroin.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Heroin.Approved, Vet Approved
ProcyclidineThe risk or severity of adverse effects can be increased when Procyclidine is combined with Heroin.Approved
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Heroin.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Heroin is combined with Promethazine.Approved
PropanthelineThe risk or severity of adverse effects can be increased when Propantheline is combined with Heroin.Approved
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Heroin.Approved, Vet Approved
PropiopromazinePropiopromazine may increase the hypotensive activities of Heroin.Vet Approved
PropiverineThe risk or severity of adverse effects can be increased when Propiverine is combined with Heroin.Investigational
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Heroin.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Heroin is combined with Propoxycaine.Approved
ProtriptylineThe risk or severity of adverse effects can be increased when Heroin is combined with Protriptyline.Approved
PSD502The risk or severity of adverse effects can be increased when Heroin is combined with PSD502.Investigational
PseudoephedrinePseudoephedrine may increase the analgesic activities of Heroin.Approved
QuazepamThe risk or severity of adverse effects can be increased when Heroin is combined with Quazepam.Approved, Illicit
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Heroin.Approved
QuinethazoneThe risk or severity of adverse effects can be increased when Heroin is combined with Quinethazone.Approved
QuinidineThe risk or severity of adverse effects can be increased when Quinidine is combined with Heroin.Approved
RacloprideThe risk or severity of adverse effects can be increased when Heroin is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Heroin is combined with Ramelteon.Approved, Investigational
RamosetronHeroin may increase the constipating activities of Ramosetron.Approved
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Heroin.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Heroin.Approved, Withdrawn
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Heroin.Approved
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Heroin.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Heroin is combined with Ritanserin.Investigational
RitobegronRitobegron may increase the analgesic activities of Heroin.Investigational
RolofyllineThe risk or severity of adverse effects can be increased when Heroin is combined with Rolofylline.Investigational
RomifidineThe risk or severity of adverse effects can be increased when Heroin is combined with Romifidine.Vet Approved
RopiniroleHeroin may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Heroin.Approved
RotigotineHeroin may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Heroin.Approved
S-EthylisothioureaThe risk or severity of adverse effects can be increased when Heroin is combined with S-Ethylisothiourea.Experimental
Sage 547The risk or severity of adverse effects can be increased when Heroin is combined with Sage 547.Investigational
ScopolamineThe risk or severity of adverse effects can be increased when Heroin is combined with Scopolamine.Approved
Scopolamine butylbromideThe risk or severity of adverse effects can be increased when Scopolamine butylbromide is combined with Heroin.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Heroin.Approved, Vet Approved
SertindoleThe risk or severity of adverse effects can be increased when Heroin is combined with Sertindole.Approved, Withdrawn
SertralineHeroin may increase the serotonergic activities of Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Heroin.Approved, Vet Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Heroin.Approved
SolifenacinThe risk or severity of adverse effects can be increased when Solifenacin is combined with Heroin.Approved
SpironolactoneThe risk or severity of adverse effects can be increased when Heroin is combined with Spironolactone.Approved
StiripentolThe risk or severity of adverse effects can be increased when Heroin is combined with Stiripentol.Approved
SuccinylcholineSuccinylcholine may increase the bradycardic activities of Heroin.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Heroin.Approved, Investigational
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Heroin.Approved
SuvorexantHeroin may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TandospironeThe risk or severity of adverse effects can be increased when Heroin is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Heroin.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Heroin is combined with Tasimelteon.Approved
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Heroin.Approved
TetrabenazineThe risk or severity of adverse effects can be increased when Heroin is combined with Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Heroin is combined with Tetracaine.Approved, Vet Approved
TetrodotoxinThe risk or severity of adverse effects can be increased when Heroin is combined with Tetrodotoxin.Investigational
ThalidomideHeroin may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
TheobromineThe risk or severity of adverse effects can be increased when Heroin is combined with Theobromine.Approved
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Heroin.Approved, Vet Approved
ThiethylperazineThiethylperazine may increase the hypotensive activities of Heroin.Withdrawn
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Heroin.Approved, Vet Approved
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Heroin.Approved
ThiothixeneThe risk or severity of adverse effects can be increased when Heroin is combined with Thiothixene.Approved
TiagabineThe risk or severity of adverse effects can be increased when Heroin is combined with Tiagabine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Heroin is combined with Tiapride.Investigational
TicrynafenThe risk or severity of adverse effects can be increased when Heroin is combined with Ticrynafen.Withdrawn
TiletamineThe risk or severity of adverse effects can be increased when Heroin is combined with Tiletamine.Vet Approved
TiotropiumThe risk or severity of adverse effects can be increased when Tiotropium is combined with Heroin.Approved
TizanidineThe risk or severity of adverse effects can be increased when Heroin is combined with Tizanidine.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Heroin is combined with Tolcapone.Approved, Withdrawn
TolterodineThe risk or severity of adverse effects can be increased when Tolterodine is combined with Heroin.Approved, Investigational
TolvaptanThe risk or severity of adverse effects can be increased when Heroin is combined with Tolvaptan.Approved
TopiramateThe risk or severity of adverse effects can be increased when Heroin is combined with Topiramate.Approved
TorasemideThe risk or severity of adverse effects can be increased when Heroin is combined with Torasemide.Approved
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Heroin.Approved, Investigational
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Heroin is combined with Trans-2-Phenylcyclopropylamine.Experimental
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Heroin.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Heroin.Approved, Investigational
TriamtereneThe risk or severity of adverse effects can be increased when Heroin is combined with Triamterene.Approved
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Heroin.Approved
TrichlormethiazideThe risk or severity of adverse effects can be increased when Heroin is combined with Trichlormethiazide.Approved, Vet Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Heroin.Approved
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Heroin.Approved, Vet Approved
TrihexyphenidylThe risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Heroin.Approved
TrimethaphanThe risk or severity of adverse effects can be increased when Trimethaphan is combined with Heroin.Approved
TrimipramineThe risk or severity of adverse effects can be increased when Heroin is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Heroin is combined with Triprolidine.Approved
TropicamideThe risk or severity of adverse effects can be increased when Tropicamide is combined with Heroin.Approved
TrospiumThe risk or severity of adverse effects can be increased when Trospium is combined with Heroin.Approved
TubocurarineThe risk or severity of adverse effects can be increased when Tubocurarine is combined with Heroin.Approved
Uc1010The risk or severity of adverse effects can be increased when Heroin is combined with Uc1010.Investigational
UlaritideThe risk or severity of adverse effects can be increased when Heroin is combined with Ularitide.Investigational
UmeclidiniumThe risk or severity of adverse effects can be increased when Umeclidinium is combined with Heroin.Approved
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Heroin.Approved, Investigational
VecuroniumThe risk or severity of adverse effects can be increased when Vecuronium is combined with Heroin.Approved
VenlafaxineHeroin may increase the serotonergic activities of Venlafaxine.Approved
VigabatrinThe risk or severity of adverse effects can be increased when Heroin is combined with Vigabatrin.Approved
VortioxetineThe risk or severity of adverse effects can be increased when Heroin is combined with Vortioxetine.Approved
XylazineThe risk or severity of adverse effects can be increased when Heroin is combined with Xylazine.Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Heroin.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Heroin is combined with Ziconotide.Approved
ZimelidineHeroin may increase the serotonergic activities of Zimelidine.Withdrawn
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Heroin.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Heroin is combined with Zolazepam.Vet Approved
ZolpidemHeroin may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Heroin is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Heroin.Approved
ZotepineThe risk or severity of adverse effects can be increased when Heroin is combined with Zotepine.Approved
ZuclopenthixolThe risk or severity of adverse effects can be increased when Heroin is combined with Zuclopenthixol.Approved, Investigational
Food Interactions
  • Avoid alcohol
  • To avoid constipation: increase your daily intake of fiber (beans, whole grains, vegetables).
References
Synthesis ReferenceNot Available
General References
  1. Tschacher W, Haemmig R, Jacobshagen N: Time series modeling of heroin and morphine drug action. Psychopharmacology (Berl). 2003 Jan;165(2):188-93. Epub 2002 Oct 29. [PubMed:12404073 ]
External Links
ATC CodesN07BC06
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (18.8 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9932
Blood Brain Barrier+0.9892
Caco-2 permeable+0.7924
P-glycoprotein substrateSubstrate0.837
P-glycoprotein inhibitor IInhibitor0.8674
P-glycoprotein inhibitor IINon-inhibitor0.6816
Renal organic cation transporterNon-inhibitor0.5372
CYP450 2C9 substrateNon-substrate0.8192
CYP450 2D6 substrateSubstrate0.6599
CYP450 3A4 substrateSubstrate0.7803
CYP450 1A2 substrateNon-inhibitor0.7994
CYP450 2C9 inhibitorNon-inhibitor0.8162
CYP450 2D6 inhibitorNon-inhibitor0.6335
CYP450 2C19 inhibitorNon-inhibitor0.8059
CYP450 3A4 inhibitorNon-inhibitor0.8072
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8335
Ames testNon AMES toxic0.6935
CarcinogenicityNon-carcinogens0.9341
BiodegradationNot ready biodegradable0.9696
Rat acute toxicity2.8951 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9038
hERG inhibition (predictor II)Non-inhibitor0.9086
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point173 °CPhysProp
boiling point272-274 °C at 1.20E+01 mm HgPhysProp
water solubility600 mg/L (at 25 °C)SEIDELL,A (1941)
logP1.58AVDEEF,A ET AL. (1996)
pKa7.95 (at 25 °C)AVDEEF,A ET AL. (1996)
Predicted Properties
PropertyValueSource
Water Solubility0.266 mg/mLALOGPS
logP2.3ALOGPS
logP1.55ChemAxon
logS-3.1ALOGPS
pKa (Strongest Basic)9.1ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area65.07 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity98.43 m3·mol-1ChemAxon
Polarizability37.9 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
MSMass Spectrum (Electron Ionization)splash10-016u-5955000000-17dd3ef75849a9fb63c3View in MoNA
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as morphinans. These are polycyclic compounds with a four-ring skeleton with three condensed six-member rings forming a partially hydrogenated phenanthrene moiety, one of which is aromatic while the two others are alicyclic.
KingdomOrganic compounds
Super ClassAlkaloids and derivatives
ClassMorphinans
Sub ClassNot Available
Direct ParentMorphinans
Alternative Parents
Substituents
  • Morphinan
  • Benzylisoquinoline
  • Phenanthrene
  • Tetralin
  • Benzofuran
  • Aralkylamine
  • Alkyl aryl ether
  • Benzenoid
  • Piperidine
  • Acetate salt
  • Tertiary aliphatic amine
  • Tertiary amine
  • Carboxylic acid ester
  • Oxacycle
  • Azacycle
  • Organoheterocyclic compound
  • Ether
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Voltage-gated calcium channel activity
Specific Function:
Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociati...
Gene Name:
OPRM1
Uniprot ID:
P35372
Molecular Weight:
44778.855 Da
References
  1. Greenwald MK, Johanson CE, Moody DE, Woods JH, Kilbourn MR, Koeppe RA, Schuster CR, Zubieta JK: Effects of buprenorphine maintenance dose on mu-opioid receptor availability, plasma concentrations, and antagonist blockade in heroin-dependent volunteers. Neuropsychopharmacology. 2003 Nov;28(11):2000-9. [PubMed:12902992 ]
  2. Becker J, Schmidt P, Musshoff F, Fitzenreiter M, Madea B: MOR1 receptor mRNA expression in human brains of drug-related fatalities-a real-time PCR quantification. Forensic Sci Int. 2004 Feb 10;140(1):13-20. [PubMed:15013161 ]
  3. Yao L, McFarland K, Fan P, Jiang Z, Inoue Y, Diamond I: Activator of G protein signaling 3 regulates opiate activation of protein kinase A signaling and relapse of heroin-seeking behavior. Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8746-51. Epub 2005 Jun 3. [PubMed:15937104 ]
  4. Antonilli L, Petecchia E, Caprioli D, Badiani A, Nencini P: Effect of repeated administrations of heroin, naltrexone, methadone, and alcohol on morphine glucuronidation in the rat. Psychopharmacology (Berl). 2005 Oct;182(1):58-64. Epub 2005 Sep 29. [PubMed:15986196 ]
  5. Choi HS, Kim CS, Hwang CK, Song KY, Wang W, Qiu Y, Law PY, Wei LN, Loh HH: The opioid ligand binding of human mu-opioid receptor is modulated by novel splice variants of the receptor. Biochem Biophys Res Commun. 2006 May 19;343(4):1132-40. Epub 2006 Mar 23. [PubMed:16580639 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Opioid receptor activity
Specific Function:
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates th...
Gene Name:
OPRK1
Uniprot ID:
P41145
Molecular Weight:
42644.665 Da
References
  1. Wee S, Koob GF: The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse. Psychopharmacology (Berl). 2010 Jun;210(2):121-35. doi: 10.1007/s00213-010-1825-8. Epub 2010 Mar 30. [PubMed:20352414 ]
  2. Klein G, Juni A, Arout CA, Waxman AR, Inturrisi CE, Kest B: Acute and chronic heroin dependence in mice: contribution of opioid and excitatory amino acid receptors. Eur J Pharmacol. 2008 May 31;586(1-3):179-88. doi: 10.1016/j.ejphar.2008.02.035. Epub 2008 Feb 19. [PubMed:18343363 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Opioid receptor activity
Specific Function:
G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurot...
Gene Name:
OPRD1
Uniprot ID:
P41143
Molecular Weight:
40368.235 Da
References
  1. Klein G, Juni A, Arout CA, Waxman AR, Inturrisi CE, Kest B: Acute and chronic heroin dependence in mice: contribution of opioid and excitatory amino acid receptors. Eur J Pharmacol. 2008 May 31;586(1-3):179-88. doi: 10.1016/j.ejphar.2008.02.035. Epub 2008 Feb 19. [PubMed:18343363 ]
  2. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  3. Kieffer BL, Gaveriaux-Ruff C: Exploring the opioid system by gene knockout. Prog Neurobiol. 2002 Apr;66(5):285-306. [PubMed:12015197 ]
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Drug created on July 31, 2007 07:09 / Updated on October 25, 2016 14:08