Agents for Dermatitis, Excluding Corticosteroids

DrugDrug NameDrug Description
DB00337PimecrolimusA topical calcineurin inhibitor used in the treatment of mild-moderate atopic dermatitis who are not candidates for other types of therapy due to previous lack of response or other reasons.
DB00523AlitretinoinA vitamin A derivative used to treat Kaposi's sarcoma and used off label to treat chronic hand eczema and psoriasis.
DB00864TacrolimusA calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis.
DB01003Cromoglicic acidA medication used to treat asthma, allergic reactions of the eyes and nose, as well as other mast cell reactions.
DB05219CrisaboroleA non-steroidal topical medication used for the treatment of mild-moderate atopic dermatitis.
DB12159DupilumabA monoclonal antibody used to treat moderate to severe atopic dermatitis, asthma, and nasal polyps accompanied by chronic rhinosinusitis in adolescents and adults.
DrugDrug NameTargetType
DB00337PimecrolimusPeptidyl-prolyl cis-trans isomerase FKBP1Atarget
DB00337PimecrolimusSerine/threonine-protein kinase mTORtarget
DB00337PimecrolimusCytochrome P450 3A4enzyme
DB00523AlitretinoinRetinoic acid receptor alphatarget
DB00523AlitretinoinRetinoic acid receptor RXR-betatarget
DB00523AlitretinoinRetinoic acid receptor gammatarget
DB00523AlitretinoinRetinoic acid receptor betatarget
DB00523AlitretinoinRetinoic acid receptor RXR-gammatarget
DB00523AlitretinoinRetinoic acid receptor RXR-alphatarget
DB00523AlitretinoinCellular retinoic acid-binding protein 2carrier
DB00523AlitretinoinCellular retinoic acid-binding protein 1carrier
DB00523AlitretinoinP-glycoprotein 1transporter
DB00523AlitretinoinInsulin-like growth factor-binding protein 3target
DB00523AlitretinoinPregnancy-specific beta-1-glycoprotein 5target
DB00523AlitretinoinCytochrome P450 26C1target
DB00864TacrolimusPeptidyl-prolyl cis-trans isomerase FKBP1Atarget
DB00864TacrolimusCytochrome P450 3A4enzyme
DB00864TacrolimusCytochrome P450 3A5enzyme
DB00864TacrolimusP-glycoprotein 1transporter
DB00864TacrolimusATP-binding cassette sub-family A member 5transporter
DB00864TacrolimusSerum albumincarrier
DB00864TacrolimusAlpha-1-acid glycoprotein 1carrier
DB00864TacrolimusSolute carrier organic anion transporter family member 1B1transporter
DB01003Cromoglicic acidCalcium-activated potassium channel subunit alpha-1target
DB01003Cromoglicic acidProtein S100-Ptarget
DB05219CrisaborolecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DB05219CrisaborolecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB05219CrisaborolecAMP-specific 3',5'-cyclic phosphodiesterase 4Ctarget
DB05219CrisaborolecAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
DB05219CrisaboroleCytochrome P450 2B6enzyme
DB05219CrisaboroleCytochrome P450 2C8enzyme
DB05219CrisaboroleCytochrome P450 2C9enzyme
DB12159DupilumabInterleukin-4 receptor subunit alphatarget