Identification

Name
Tacrolimus
Accession Number
DB00864  (APRD00276, EXPT01437)
Type
Small Molecule
Groups
Approved, Investigational
Description

Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo. It was discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. Tacrolimus is chemically known as a macrolide. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin thus inhibiting both T-lymphocyte signal transduction and IL-2 transcription.

Structure
Thumb
Synonyms
  • Anhydrous tacrolimus
  • Tacrolimus anhydrous
  • Tacrolimus, anhydrous
External IDs
FK-506 / FK5 / K506
Product Ingredients
IngredientUNIICASInChI Key
Tacrolimus hydrateWM0HAQ4WNM109581-93-3NWJQLQGQZSIBAF-MSLXHMNKSA-N
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Ach-tacrolimusCapsule1 mgOralAccord Healthcare LimitedNot applicableNot applicableCanada
Ach-tacrolimusCapsule0.5 mgOralAccord Healthcare LimitedNot applicableNot applicableCanada
Ach-tacrolimusCapsule5 mgOralAccord Healthcare LimitedNot applicableNot applicableCanada
AdvagrafCapsule, extended release3 mgOralAstellas Pharma Europe Bv2007-04-23Not applicableEu
AdvagrafCapsule, extended release3 mgOralAstellas Pharma Europe Bv2007-04-23Not applicableEu
AdvagrafCapsule, extended release1 mgOralAstellas Pharma Europe Bv2007-04-23Not applicableEu
AdvagrafCapsule, extended release5 mgOralAstellas Pharma Europe Bv2007-04-23Not applicableEu
AdvagrafCapsule, extended release0.5 mgOralAstellas Pharma Inc2008-04-09Not applicableCanada
AdvagrafCapsule, extended release0.5 mgOralAstellas Pharma Europe Bv2007-04-23Not applicableEu
AdvagrafCapsule, extended release3 mgOralAstellas Pharma Europe Bv2007-04-23Not applicableEu
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-tacrolimusCapsule1 mgOralApotex CorporationNot applicableNot applicableCanada
Apo-tacrolimusCapsule5 mgOralApotex CorporationNot applicableNot applicableCanada
Apo-tacrolimusCapsule0.5 mgOralApotex CorporationNot applicableNot applicableCanada
HecoriaCapsule.5 mg/1OralNovartis2011-12-20Not applicableUs
HecoriaCapsule1 mg/1OralNovartis2011-12-20Not applicableUs
HecoriaCapsule5 mg/1OralNovartis2011-12-20Not applicableUs
TacrolimusCapsule5 mg/1OralSandoz2012-01-15Not applicableUs
TacrolimusCapsule, gelatin coated5 mg/1OralBionpharma Inc.2016-02-26Not applicableUs
TacrolimusCapsule.5 mg/1OralMajor2010-05-14Not applicableUs
TacrolimusCapsule.5 mg/1OralMylan Institutional2010-11-15Not applicableUs
Categories
UNII
Y5L2157C4J
CAS number
104987-11-3
Weight
Average: 804.0182
Monoisotopic: 803.481976677
Chemical Formula
C44H69NO12
InChI Key
QJJXYPPXXYFBGM-LFZNUXCKSA-N
InChI
InChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19+,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1
IUPAC Name
(1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-(prop-2-en-1-yl)-11,28-dioxa-4-azatricyclo[22.3.1.0⁴,⁹]octacos-18-ene-2,3,10,16-tetrone
SMILES

Pharmacology

Indication

For use after allogenic organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It was first approved by the FDA in 1994 for use in liver transplantation, this has been extended to include kidney, heart, small bowel, pancreas, lung, trachea, skin, cornea, and limb transplants. It has also been used in a topical preparation in the treatment of severe atopic dermatitis.

Structured Indications
Pharmacodynamics

Tacrolimus is a macrolide antibiotic. It acts by reducing peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This inhibits both T-lymphocyte signal transduction and IL-2 transcription. Although this activity is similar to cyclosporine studies have shown that the incidence of acute rejection is reduced by tacrolimus use over cyclosporine. Tacrolimus has also been shown to be effective in the topical treatment of eczema, particularly atopic eczema. It suppresses inflammation in a similar way to steroids, but is not as powerful. An important dermatological advantage of tacrolimus is that it can be used directly on the face; topical steroids cannot be used on the face, as they thin the skin dramatically there. On other parts of the body, topical steroid are generally a better treatment.

Mechanism of action

The mechanism of action of tacrolimus in atopic dermatitis is not known. While the following have been observed, the clinical significance of these observations in atopic dermatitis is not known. It has been demonstrated that tacrolimus inhibits T-lymphocyte activation by first binding to an intracellular protein, FKBP-12. A complex of tacrolimus-FKBP-12, calcium, calmodulin, and calcineurin is then formed and the phosphatase activity of calcineurin is inhibited. This prevents the dephosphorylation and translocation of nuclear factor of activated T-cells (NF-AT), a nuclear component thought to initiate gene transcription for the formation of lymphokines. Tacrolimus also inhibits the transcription for genes which encode IL-3, IL-4, IL-5, GM-CSF, and TNF-, all of which are involved in the early stages of T-cell activation. Additionally, tacrolimus has been shown to inhibit the release of pre-formed mediators from skin mast cells and basophils, and to downregulate the expression of FceRI on Langerhans cells.

TargetActionsOrganism
APeptidyl-prolyl cis-trans isomerase FKBP1A
inhibitor
Human
Absorption

Absorption of tacrolimus from the gastrointestinal tract after oral administration is incomplete and variable. The absolute bioavailability in adult kidney transplant patients is 17±10%; in adults liver transplant patients is 22±6%; in healthy subjects is 18±5%. The absolute bioavailability in pediatric liver transplant patients was 31±24%. Tacrolimus maximum blood concentrations (Cmax) and area under the curve (AUC) appeared to increase in a dose-proportional fashion in 18 fasted healthy volunteers receiving a single oral dose of 3, 7, and 10 mg. When given without food, the rate and extent of absorption were the greatest. The time of the meal also affected bioavailability. When given immediately after a meal, mean Cmax was reduced 71%, and mean AUC was reduced 39%, relative to the fasted condition. When administered 1.5 hours following the meal, mean Cmax was reduced 63%, and mean AUC was reduced 39%, relative to the fasted condition.

Volume of distribution
  • 2.6 ± 2.1 L/kg [pediatric liver transplant patients]
  • 1.07 ± 0.20 L/kg [patients with renal impairment, 0.02 mg/kg/4 hr dose, IV]
  • 3.1 ± 1.6 L/kg [Mild Hepatic Impairment, 0.02 mg/kg/4 hr dose, IV]
  • 3.7 ± 4.7 L/kg [Mild Hepatic Impairment, 7.7 mg dose, PO]
  • 3.9 ± 1.0 L/kg [Severe hepatic impairment, 0.02 mg/kg/4 hr dose, IV]
  • 3.1 ± 3.4 L/kg [Severe hepatic impairment, 8 mg dose, PO]
Protein binding

~99% bound to human plasma protein, primarily to albumin and alpha-1-acid glycoprotein. This is independent of concentration over a range of 5-50 ng/mL.

Metabolism

Hepatic, extensive, primarily by CYP3A4. The major metabolite identified in incubations with human liver microsomes is 13-demethyl tacrolimus. In in vitro studies, a 31-demethyl metabolite has been reported to have the same activity as tacrolimus.

Route of elimination

In man, less than 1% of the dose administered is excreted unchanged in urine. When administered IV, fecal elimination accounted for 92.6±30.7%, urinary elimination accounted for 2.3±1.1%.

Half life

The elimination half life in adult healthy volunteers, kidney transplant patients, liver transplants patients, and heart transplant patients are approximately 35, 19, 12, 24 hours, respectively. The elimination half life in pediatric liver transplant patients was 11.5±3.8 hours, in pediatric kidney transplant patients was 10.2±5.0 (range 3.4-25) hours.

Clearance
  • 0.040 L/hr/kg [healthy subjects, IV]
  • 0.172 ± 0.088 L/hr/kg [healthy subjects, oral]
  • 0.083 L/hr/kg [adult kidney transplant patients, IV]
  • 0.053 L/hr/kg [adult liver transplant patients, IV]
  • 0.051 L/hr/kg [adult heart transplant patients, IV]
  • 0.138 ± 0.071 L/hr/kg [pediatric liver transplant patients]
  • 0.12 ± 0.04 (range 0.06-0.17) L/hr/kg [pediatric kidney transplant patients]
  • 0.038 ± 0.014 L/hr/kg [patients with renal impairment, 0.02 mg/kg/4 hr dose, IV]
  • 0.042 ± 0.02 L/hr/kg [Mild Hepatic Impairment, 0.02 mg/kg/4 hr dose, IV]
  • 0.034 ± 0.019 L/hr/kg [Mild Hepatic Impairment, 7.7 mg dose, PO]
  • 0.017 ± 0.013 L/hr/kg [Severe hepatic impairment, 0.02 mg/kg/4 hr dose, IV]
  • 0.016 ± 0.011 L/hr/kg [Severe hepatic impairment, 8 mg dose, PO]
Toxicity

Side effects can be severe and include blurred vision, liver and kidney problems (it is nephrotoxic), seizures, tremors, hypertension, hypomagnesemia, diabetes mellitus, hyperkalemia, itching, insomnia, confusion. LD50=134-194 mg/kg (rat).

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Interacting Gene/EnzymeAllele nameGenotype(s)Defining Change(s)Type(s)DescriptionDetails
Multidrug resistance protein 1---(T;T) / (G;T)T Allele (G2677T)ADR Directly StudiedThe presence of this genotype in ABCB1 may indicate an increased risk of drug-induced neurotoxicity when treated with tacrolimus.Details
Cytochrome P450 3A5CYP3A5*1Not AvailableFunctional geneEffect Directly StudiedPatients with this genotype in CYP3A5 are extensive metabolizers and require higer doses of tacrolimus to attain the therapeutic effect.Details

Interactions

Drug Interactions
DrugInteractionDrug group
1,10-PhenanthrolineThe metabolism of Tacrolimus can be decreased when combined with 1,10-Phenanthroline.Experimental
2-HYDROXY-1,4-NAPHTHOQUINONEThe metabolism of Tacrolimus can be decreased when combined with 2-HYDROXY-1,4-NAPHTHOQUINONE.Experimental
2-mercaptobenzothiazoleThe metabolism of Tacrolimus can be decreased when combined with 2-mercaptobenzothiazole.Vet Approved
2-MethoxyethanolThe risk or severity of adverse effects can be increased when Tacrolimus is combined with 2-Methoxyethanol.Experimental
2,4-thiazolidinedioneThe therapeutic efficacy of 2,4-thiazolidinedione can be decreased when used in combination with Tacrolimus.Investigational
3,4-DichloroisocoumarinThe metabolism of Tacrolimus can be decreased when combined with 3,4-Dichloroisocoumarin.Experimental
4-(2-Aminoethyl)Benzenesulfonyl FluorideThe metabolism of Tacrolimus can be decreased when combined with 4-(2-Aminoethyl)Benzenesulfonyl Fluoride.Experimental
AbataceptThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Abatacept.Approved
abetimusThe risk or severity of adverse effects can be increased when Tacrolimus is combined with abetimus.Investigational
AcarboseThe therapeutic efficacy of Acarbose can be decreased when used in combination with Tacrolimus.Approved, Investigational
AcebutololThe serum concentration of Acebutolol can be decreased when it is combined with Tacrolimus.Approved
AceclofenacAceclofenac may increase the nephrotoxic activities of Tacrolimus.Approved
AcemetacinAcemetacin may increase the nephrotoxic activities of Tacrolimus.Approved
AcetaminophenThe serum concentration of Acetaminophen can be decreased when it is combined with Tacrolimus.Approved
AcetohexamideThe therapeutic efficacy of Acetohexamide can be decreased when used in combination with Tacrolimus.Withdrawn
Acetylsalicylic acidAcetylsalicylic acid may increase the nephrotoxic activities of Tacrolimus.Approved, Vet Approved
ActeosideThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Acteoside.Investigational
AdalimumabThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Adalimumab.Approved
AdapaleneAdapalene may increase the nephrotoxic activities of Tacrolimus.Approved
AdefovirThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Adefovir.Investigational
AfatinibThe serum concentration of Afatinib can be decreased when it is combined with Tacrolimus.Approved
AfelimomabThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Afelimomab.Investigational
AICA ribonucleotideThe therapeutic efficacy of AICA ribonucleotide can be decreased when used in combination with Tacrolimus.Experimental
AlaproclateThe metabolism of Tacrolimus can be decreased when combined with Alaproclate.Experimental
AlbendazoleThe serum concentration of Tacrolimus can be increased when it is combined with Albendazole.Approved, Vet Approved
AlclofenacAlclofenac may increase the nephrotoxic activities of Tacrolimus.Approved, Withdrawn
AldosteroneThe serum concentration of Tacrolimus can be decreased when it is combined with Aldosterone.Experimental
AlectinibThe serum concentration of Tacrolimus can be increased when it is combined with Alectinib.Approved
AlefaceptThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Alefacept.Approved, Withdrawn
AlemtuzumabThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Alemtuzumab.Approved, Investigational
AlfentanilThe serum concentration of Tacrolimus can be increased when it is combined with Alfentanil.Approved, Illicit
AlicaforsenThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Alicaforsen.Investigational
AlitretinoinThe serum concentration of Alitretinoin can be decreased when it is combined with Tacrolimus.Approved, Investigational
AllicinThe therapeutic efficacy of Allicin can be decreased when used in combination with Tacrolimus.Investigational
AlminoprofenAlminoprofen may increase the nephrotoxic activities of Tacrolimus.Experimental
AlogliptinThe metabolism of Tacrolimus can be decreased when combined with Alogliptin.Approved
Alpha-1-proteinase inhibitorThe metabolism of Tacrolimus can be decreased when combined with Alpha-1-proteinase inhibitor.Approved
AltretamineThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Altretamine.Approved
AmantadineThe serum concentration of Tacrolimus can be increased when it is combined with Amantadine.Approved
AmbrisentanThe serum concentration of Ambrisentan can be decreased when it is combined with Tacrolimus.Approved, Investigational
AmilorideAmiloride may increase the hyperkalemic activities of Tacrolimus.Approved
Aminohippuric acidThe serum concentration of Tacrolimus can be increased when it is combined with Aminohippuric acid.Approved
AmiodaroneThe metabolism of Tacrolimus can be decreased when combined with Amiodarone.Approved, Investigational
AmitriptylineThe serum concentration of Amitriptyline can be decreased when it is combined with Tacrolimus.Approved
AmorolfineThe metabolism of Tacrolimus can be decreased when combined with Amorolfine.Approved
AmoxapineThe metabolism of Tacrolimus can be decreased when combined with Amoxapine.Approved
Amphotericin BThe metabolism of Tacrolimus can be decreased when combined with Amphotericin B.Approved, Investigational
AmprenavirThe metabolism of Tacrolimus can be decreased when combined with Amprenavir.Approved
AmsacrineThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Amsacrine.Approved
AnakinraThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Anakinra.Approved
AndrographolideAndrographolide may increase the nephrotoxic activities of Tacrolimus.Investigational
AnidulafunginThe metabolism of Tacrolimus can be decreased when combined with Anidulafungin.Approved, Investigational
AnisodamineAnisodamine may increase the nephrotoxic activities of Tacrolimus.Investigational
Antilymphocyte immunoglobulin (horse)The risk or severity of adverse effects can be increased when Tacrolimus is combined with Antilymphocyte immunoglobulin (horse).Approved
AntipyrineAntipyrine may increase the nephrotoxic activities of Tacrolimus.Approved
Antithrombin III humanThe metabolism of Tacrolimus can be decreased when combined with Antithrombin III human.Approved
Antithymocyte immunoglobulin (rabbit)The risk or severity of adverse effects can be increased when Tacrolimus is combined with Antithymocyte immunoglobulin (rabbit).Approved
ApixabanThe metabolism of Tacrolimus can be decreased when combined with Apixaban.Approved
ApocyninApocynin may increase the nephrotoxic activities of Tacrolimus.Investigational
ApremilastApremilast may increase the nephrotoxic activities of Tacrolimus.Approved, Investigational
AprepitantThe serum concentration of Tacrolimus can be increased when it is combined with Aprepitant.Approved, Investigational
AprotininThe metabolism of Tacrolimus can be decreased when combined with Aprotinin.Approved, Withdrawn
ArgatrobanThe metabolism of Tacrolimus can be decreased when combined with Argatroban.Approved, Investigational
Arsenic trioxideThe serum concentration of Arsenic trioxide can be decreased when it is combined with Tacrolimus.Approved, Investigational
ArtemetherThe metabolism of Tacrolimus can be decreased when combined with Artemether.Approved
AstemizoleThe serum concentration of Tacrolimus can be increased when it is combined with Astemizole.Approved, Withdrawn
AsunaprevirThe metabolism of Tacrolimus can be decreased when combined with Asunaprevir.Approved, Investigational
AtazanavirThe metabolism of Tacrolimus can be decreased when combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Atenolol can be decreased when it is combined with Tacrolimus.Approved
AtomoxetineThe metabolism of Tacrolimus can be decreased when combined with Atomoxetine.Approved
AtorvastatinThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Atorvastatin.Approved
AxitinibThe serum concentration of Axitinib can be decreased when it is combined with Tacrolimus.Approved, Investigational
AzacitidineThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Azacitidine.Approved, Investigational
AzapropazoneAzapropazone may increase the nephrotoxic activities of Tacrolimus.Withdrawn
AzathioprineThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Azathioprine.Approved
AzelastineAzelastine may increase the nephrotoxic activities of Tacrolimus.Approved
AzithromycinThe serum concentration of Tacrolimus can be increased when it is combined with Azithromycin.Approved
Bafilomycin A1The metabolism of Tacrolimus can be decreased when combined with Bafilomycin A1.Experimental
BalaglitazoneThe therapeutic efficacy of Balaglitazone can be decreased when used in combination with Tacrolimus.Investigational
BalsalazideBalsalazide may increase the nephrotoxic activities of Tacrolimus.Approved, Investigational
BasiliximabThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Basiliximab.Approved, Investigational
BatimastatThe metabolism of Tacrolimus can be decreased when combined with Batimastat.Experimental
BCG vaccineThe therapeutic efficacy of BCG vaccine can be decreased when used in combination with Tacrolimus.Investigational
BegelomabThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Begelomab.Experimental
BelataceptThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Belatacept.Approved
BelimumabThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Belimumab.Approved
BelinostatThe serum concentration of Belinostat can be decreased when it is combined with Tacrolimus.Approved, Investigational
Bempedoic acidThe therapeutic efficacy of Bempedoic acid can be decreased when used in combination with Tacrolimus.Investigational
BenazeprilThe metabolism of Tacrolimus can be decreased when combined with Benazepril.Approved, Investigational
BendazacBendazac may increase the nephrotoxic activities of Tacrolimus.Experimental
BenorilateBenorilate may increase the nephrotoxic activities of Tacrolimus.Experimental
BenoxaprofenBenoxaprofen may increase the nephrotoxic activities of Tacrolimus.Withdrawn
BenzamidineThe metabolism of Tacrolimus can be decreased when combined with Benzamidine.Experimental
BenznidazoleThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Benznidazole.Approved
BenzocaineThe serum concentration of Tacrolimus can be increased when it is combined with Benzocaine.Approved
Benzoic AcidThe metabolism of Tacrolimus can be decreased when combined with Benzoic Acid.Approved
BepridilThe serum concentration of Tacrolimus can be increased when it is combined with Bepridil.Approved, Withdrawn
BetamethasoneThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Betamethasone.Approved, Vet Approved
BevoniumBevonium may increase the nephrotoxic activities of Tacrolimus.Experimental
BifonazoleThe metabolism of Tacrolimus can be decreased when combined with Bifonazole.Approved
BiperidenThe serum concentration of Tacrolimus can be increased when it is combined with Biperiden.Approved
BivalirudinThe metabolism of Tacrolimus can be decreased when combined with Bivalirudin.Approved, Investigational
BleomycinThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Bleomycin.Approved
BlinatumomabThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Blinatumomab.Approved
BoceprevirThe serum concentration of Tacrolimus can be increased when it is combined with Boceprevir.Withdrawn
BortezomibThe metabolism of Tacrolimus can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Tacrolimus can be decreased when it is combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Tacrolimus.Approved
Brefeldin AThe metabolism of Tacrolimus can be decreased when combined with 1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN-4-ONE.Experimental
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be decreased when it is combined with Tacrolimus.Approved
BriakinumabThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Briakinumab.Investigational
BrodalumabThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Brodalumab.Approved, Investigational
BromfenacBromfenac may increase the nephrotoxic activities of Tacrolimus.Approved
BromocriptineThe serum concentration of Bromocriptine can be decreased when it is combined with Tacrolimus.Approved, Investigational
BucillamineBucillamine may increase the nephrotoxic activities of Tacrolimus.Investigational
BudesonideThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Budesonide.Approved
BufexamacBufexamac may increase the nephrotoxic activities of Tacrolimus.Experimental
BuforminThe therapeutic efficacy of Buformin can be decreased when used in combination with Tacrolimus.Withdrawn
BumadizoneBumadizone may increase the nephrotoxic activities of Tacrolimus.Experimental
BuprenorphineThe serum concentration of Tacrolimus can be increased when it is combined with Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe serum concentration of Tacrolimus can be increased when it is combined with Buspirone.Approved, Investigational
BusulfanThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Busulfan.Approved, Investigational
ButenafineThe metabolism of Tacrolimus can be decreased when combined with Butenafine.Approved
ButoconazoleThe metabolism of Tacrolimus can be decreased when combined with Butoconazole.Approved
CabazitaxelThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Cabazitaxel.Approved
CabergolineThe risk or severity of adverse effects can be increased when Cabergoline is combined with Tacrolimus.Approved
CaffeineThe serum concentration of Caffeine can be decreased when it is combined with Tacrolimus.Approved
CamostatThe metabolism of Tacrolimus can be decreased when combined with Camostat.Experimental
CamptothecinThe serum concentration of Camptothecin can be decreased when it is combined with Tacrolimus.Experimental
CanagliflozinThe serum concentration of Canagliflozin can be decreased when it is combined with Tacrolimus.Approved
CanakinumabThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Canakinumab.Approved, Investigational
CandesartanThe serum concentration of Tacrolimus can be increased when it is combined with Candesartan.Approved
CandicidinThe metabolism of Tacrolimus can be decreased when combined with Candicidin.Withdrawn
CandoxatrilThe metabolism of Tacrolimus can be decreased when combined with Candoxatril.Experimental
CandoxatrilatThe metabolism of Tacrolimus can be decreased when combined with Candoxatrilat.Experimental
CapecitabineThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Capecitabine.Approved, Investigational
Capric acidThe metabolism of Tacrolimus can be decreased when combined with Capric acid.Experimental
CaptoprilThe metabolism of Tacrolimus can be decreased when combined with Captopril.Approved
CarbamazepineThe metabolism of Tacrolimus can be increased when combined with Carbamazepine.Approved, Investigational
Carbaspirin calciumCarbaspirin calcium may increase the nephrotoxic activities of Tacrolimus.Experimental
CarbomycinThe serum concentration of Tacrolimus can be increased when it is combined with Carbomycin.Vet Approved
CarboplatinThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Carboplatin.Approved
CarbutamideThe therapeutic efficacy of Carbutamide can be decreased when used in combination with Tacrolimus.Experimental
CarfilzomibThe serum concentration of Carfilzomib can be decreased when it is combined with Tacrolimus.Approved
CarmustineThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Carmustine.Approved
CarprofenCarprofen may increase the nephrotoxic activities of Tacrolimus.Approved, Vet Approved, Withdrawn
CarvedilolThe serum concentration of Tacrolimus can be increased when it is combined with Carvedilol.Approved, Investigational
CaspofunginThe serum concentration of Tacrolimus can be decreased when it is combined with Caspofungin.Approved
CastanospermineCastanospermine may increase the nephrotoxic activities of Tacrolimus.Experimental
CelecoxibCelecoxib may increase the nephrotoxic activities of Tacrolimus.Approved, Investigational
CeritinibThe serum concentration of Tacrolimus can be increased when it is combined with Ceritinib.Approved
CerivastatinThe serum concentration of Cerivastatin can be decreased when it is combined with Tacrolimus.Withdrawn
Certolizumab pegolThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Certolizumab pegol.Approved
CeruleninThe metabolism of Tacrolimus can be decreased when combined with Cerulenin.Approved
ChlorambucilThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Chlorambucil.Approved
ChloramphenicolThe serum concentration of Tacrolimus can be increased when it is combined with Chloramphenicol.Approved, Vet Approved
ChloroquineChloroquine may increase the nephrotoxic activities of Tacrolimus.Approved, Vet Approved
ChloroxineThe metabolism of Tacrolimus can be decreased when combined with Chloroxine.Approved
ChlorpromazineThe serum concentration of Chlorpromazine can be decreased when it is combined with Tacrolimus.Approved, Vet Approved
ChlorpropamideThe serum concentration of Tacrolimus can be increased when it is combined with Chlorpropamide.Approved
ChlorprothixeneThe serum concentration of Tacrolimus can be increased when it is combined with Chlorprothixene.Approved, Withdrawn
CholesterolThe metabolism of Tacrolimus can be decreased when combined with Cholesterol.Experimental
Cholic AcidThe serum concentration of Tacrolimus can be decreased when it is combined with Cholic Acid.Approved
Choline magnesium trisalicylateCholine magnesium trisalicylate may increase the nephrotoxic activities of Tacrolimus.Approved
ChymostatinThe metabolism of Tacrolimus can be decreased when combined with Chymostatin.Experimental
CiclopiroxThe metabolism of Tacrolimus can be decreased when combined with Ciclopirox.Approved, Investigational
CiglitazoneThe therapeutic efficacy of Ciglitazone can be decreased when used in combination with Tacrolimus.Experimental
CilastatinThe metabolism of Tacrolimus can be decreased when combined with Cilastatin.Approved
CilazaprilThe metabolism of Tacrolimus can be decreased when combined with Cilazapril.Approved
CimetidineThe serum concentration of Tacrolimus can be decreased when it is combined with Cimetidine.Approved
CinacalcetThe serum concentration of Tacrolimus can be decreased when it is combined with Cinacalcet.Approved
CiprofloxacinThe serum concentration of Ciprofloxacin can be decreased when it is combined with Tacrolimus.Approved, Investigational
CisplatinThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Cisplatin.Approved
CitalopramThe metabolism of Tacrolimus can be decreased when combined with Citalopram.Approved
CladribineThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Cladribine.Approved, Investigational
ClarithromycinThe serum concentration of Tacrolimus can be increased when it is combined with Clarithromycin.Approved
ClemastineThe metabolism of Tacrolimus can be decreased when combined with Clemastine.Approved
ClevidipineThe serum concentration of Tacrolimus can be increased when it is combined with Clevidipine.Approved
ClobazamThe serum concentration of Clobazam can be decreased when it is combined with Tacrolimus.Approved, Illicit
ClofarabineThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Clofarabine.Approved, Investigational
ClofazimineThe serum concentration of Tacrolimus can be increased when it is combined with Clofazimine.Approved, Investigational
ClomifeneThe serum concentration of Clomifene can be decreased when it is combined with Tacrolimus.Approved, Investigational
ClomipramineThe metabolism of Tacrolimus can be decreased when combined with Clomipramine.Approved, Vet Approved
ClonidineThe serum concentration of Clonidine can be decreased when it is combined with Tacrolimus.Approved
ClonixinClonixin may increase the nephrotoxic activities of Tacrolimus.Approved
ClopidogrelThe serum concentration of Clopidogrel can be decreased when it is combined with Tacrolimus.Approved, Nutraceutical
Clostridium tetani toxoid antigen (formaldehyde inactivated)The therapeutic efficacy of Clostridium tetani toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Tacrolimus.Approved
ClotrimazoleThe serum concentration of Tacrolimus can be increased when it is combined with Clotrimazole.Approved, Vet Approved
ClozapineThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Clozapine.Approved
CobicistatThe metabolism of Tacrolimus can be decreased when combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be decreased when it is combined with Tacrolimus.Approved
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Tacrolimus.Approved
ColforsinThe serum concentration of Tacrolimus can be increased when it is combined with Colforsin.Experimental
ConivaptanThe serum concentration of Tacrolimus can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated estrogensThe serum concentration of Conjugated estrogens can be decreased when it is combined with Tacrolimus.Approved
CopanlisibThe serum concentration of Copanlisib can be decreased when it is combined with Tacrolimus.Approved
CordycepinThe metabolism of Tacrolimus can be decreased when combined with Cordycepin.Investigational
CorticotropinThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Corticotropin.Approved, Vet Approved
Cortisone acetateThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Cortisone acetate.Approved
Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated)The therapeutic efficacy of Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Tacrolimus.Approved
CrizotinibThe serum concentration of Tacrolimus can be increased when it is combined with Crizotinib.Approved
CurcuminCurcumin may increase the nephrotoxic activities of Tacrolimus.Investigational
CyclophosphamideThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Cyclophosphamide.Approved, Investigational
CyclosporineTacrolimus may increase the nephrotoxic activities of Cyclosporine.Approved, Investigational, Vet Approved
CytarabineThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Cytarabine.Approved, Investigational
D-LimoneneD-Limonene may increase the nephrotoxic activities of Tacrolimus.Investigational
Dabigatran etexilateThe metabolism of Tacrolimus can be decreased when combined with Dabigatran etexilate.Approved
DabrafenibThe serum concentration of Tacrolimus can be decreased when it is combined with Dabrafenib.Approved
DacarbazineThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Dacarbazine.Approved, Investigational
DaclatasvirThe serum concentration of Tacrolimus can be increased when it is combined with Daclatasvir.Approved
DaclizumabThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Daclizumab.Approved, Investigational
DactinomycinThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Dactinomycin.Approved
DanazolThe serum concentration of Tacrolimus can be increased when it is combined with Danazol.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be decreased when it is combined with Tacrolimus.Approved
DapoxetineThe metabolism of Tacrolimus can be decreased when combined with Dapoxetine.Investigational
DarexabanThe metabolism of Tacrolimus can be decreased when combined with Darexaban.Investigational
DarunavirThe metabolism of Tacrolimus can be decreased when combined with Darunavir.Approved
DasabuvirThe serum concentration of Tacrolimus can be increased when it is combined with Dasabuvir.Approved
DasatinibThe serum concentration of Tacrolimus can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Daunorubicin.Approved
DebrisoquinThe serum concentration of Debrisoquin can be decreased when it is combined with Tacrolimus.Approved
DeferasiroxThe serum concentration of Tacrolimus can be decreased when it is combined with Deferasirox.Approved, Investigational
DeflazacortThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Deflazacort.Approved
DelanzomibThe metabolism of Tacrolimus can be decreased when combined with Delanzomib.Investigational
DelaprilThe metabolism of Tacrolimus can be decreased when combined with Delapril.Experimental
DelavirdineThe metabolism of Tacrolimus can be decreased when combined with Delavirdine.Approved
DenosumabThe risk or severity of adverse effects can be increased when Denosumab is combined with Tacrolimus.Approved
DeoxyspergualinThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Deoxyspergualin.Investigational
DesipramineThe serum concentration of Tacrolimus can be increased when it is combined with Desipramine.Approved
DesloratadineThe serum concentration of Tacrolimus can be increased when it is combined with Desloratadine.Approved, Investigational
DexamethasoneThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Dexamethasone.Approved, Investigational, Vet Approved
DexlansoprazoleThe serum concentration of Tacrolimus can be increased when it is combined with Dexlansoprazole.Approved
DexrabeprazoleThe serum concentration of Tacrolimus can be increased when it is combined with Dexrabeprazole.Experimental
DextromethorphanThe serum concentration of Tacrolimus can be increased when it is combined with Dextromethorphan.Approved
DiazepamThe serum concentration of Diazepam can be decreased when it is combined with Tacrolimus.Approved, Illicit, Vet Approved
DichloropheneThe metabolism of Tacrolimus can be decreased when combined with Dichlorophene.Vet Approved
DiclofenacDiclofenac may increase the nephrotoxic activities of Tacrolimus.Approved, Vet Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Tacrolimus.Approved
DifenpiramideDifenpiramide may increase the nephrotoxic activities of Tacrolimus.Experimental
DiflunisalDiflunisal may increase the nephrotoxic activities of Tacrolimus.Approved
DigitoxinThe serum concentration of Digitoxin can be decreased when it is combined with Tacrolimus.Approved
DigoxinThe serum concentration of Tacrolimus can be decreased when it is combined with Digoxin.Approved
DihydroergocornineThe risk or severity of adverse effects can be increased when Dihydroergocornine is combined with Tacrolimus.Approved
DihydroergocristineThe risk or severity of adverse effects can be increased when Dihydroergocristine is combined with Tacrolimus.Experimental
DihydroergocryptineThe risk or severity of adverse effects can be increased when Dihydroergocryptine is combined with Tacrolimus.Experimental
DihydroergotamineThe metabolism of Tacrolimus can be decreased when combined with Dihydroergotamine.Approved
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Tacrolimus.Illicit
Dimethyl fumarateThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Dimethyl fumarate.Approved, Investigational
DinutuximabThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Dinutuximab.Approved
DipyridamoleThe serum concentration of Dipyridamole can be decreased when it is combined with Tacrolimus.Approved
DocetaxelThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Docetaxel.Approved, Investigational
DomperidoneThe serum concentration of Domperidone can be decreased when it is combined with Tacrolimus.Approved, Investigational, Vet Approved
DoxazosinThe serum concentration of Tacrolimus can be increased when it is combined with Doxazosin.Approved
DoxepinThe serum concentration of Tacrolimus can be increased when it is combined with Doxepin.Approved
DoxifluridineThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Doxifluridine.Investigational
DoxorubicinThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Doxorubicin.Approved, Investigational
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Tacrolimus.Approved, Investigational
DoxycyclineThe metabolism of Tacrolimus can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Tacrolimus can be increased when it is combined with Dronabinol.Approved, Illicit
DronedaroneTacrolimus may increase the QTc-prolonging activities of Dronedarone.Approved
DroxicamDroxicam may increase the nephrotoxic activities of Tacrolimus.Approved
DulaglutideThe therapeutic efficacy of Dulaglutide can be decreased when used in combination with Tacrolimus.Approved
DuvelisibDuvelisib may increase the nephrotoxic activities of Tacrolimus.Investigational
E-6201E-6201 may increase the nephrotoxic activities of Tacrolimus.Investigational
EcabetThe metabolism of Tacrolimus can be decreased when combined with Ecabet.Approved, Investigational
EconazoleThe metabolism of Tacrolimus can be decreased when combined with Econazole.Approved
EculizumabThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Eculizumab.Approved, Investigational
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Tacrolimus.Approved
EfalizumabThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Efalizumab.Approved, Investigational
EfavirenzThe serum concentration of Tacrolimus can be decreased when it is combined with Efavirenz.Approved, Investigational
EfinaconazoleThe metabolism of Tacrolimus can be decreased when combined with Efinaconazole.Approved
EfonidipineThe serum concentration of Tacrolimus can be increased when it is combined with Efonidipine.Approved
ElafinThe metabolism of Tacrolimus can be decreased when combined with Elafin.Investigational
ElbasvirThe serum concentration of Elbasvir can be increased when it is combined with Tacrolimus.Approved
EletriptanThe serum concentration of Eletriptan can be decreased when it is combined with Tacrolimus.Approved, Investigational
EmpagliflozinThe therapeutic efficacy of Empagliflozin can be decreased when used in combination with Tacrolimus.Approved
EnalaprilThe metabolism of Tacrolimus can be decreased when combined with Enalapril.Approved, Vet Approved
EnalaprilatThe metabolism of Tacrolimus can be decreased when combined with Enalaprilat.Approved
EnalkirenThe metabolism of Tacrolimus can be decreased when combined with Enalkiren.Experimental
EnasidenibThe serum concentration of Enasidenib can be decreased when it is combined with Tacrolimus.Approved
EnzalutamideThe serum concentration of Tacrolimus can be decreased when it is combined with Enzalutamide.Approved
Epigallocatechin GallateThe metabolism of Tacrolimus can be decreased when combined with Epigallocatechin Gallate.Investigational
EpinastineThe serum concentration of Epinastine can be decreased when it is combined with Tacrolimus.Approved, Investigational
EpirizoleEpirizole may increase the nephrotoxic activities of Tacrolimus.Approved
EpirubicinThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Epirubicin.Approved
EplerenoneEplerenone may increase the hyperkalemic activities of Tacrolimus.Approved
ErgonovineThe serum concentration of Tacrolimus can be increased when it is combined with Ergonovine.Approved
ErgotamineThe serum concentration of Tacrolimus can be increased when it is combined with Ergotamine.Approved
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with Tacrolimus.Approved, Investigational
ErtapenemThe serum concentration of Tacrolimus can be increased when it is combined with Ertapenem.Approved, Investigational
ErythromycinThe serum concentration of Tacrolimus can be increased when it is combined with Erythromycin.Approved, Vet Approved
EscitalopramThe metabolism of Tacrolimus can be decreased when combined with Escitalopram.Approved, Investigational
EsomeprazoleThe serum concentration of Tacrolimus can be increased when it is combined with Esomeprazole.Approved, Investigational
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Tacrolimus.Approved, Investigational, Vet Approved
EstramustineThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Estramustine.Approved
EstriolThe serum concentration of Estriol can be decreased when it is combined with Tacrolimus.Approved, Vet Approved
EstroneThe serum concentration of Estrone can be decreased when it is combined with Tacrolimus.Approved
EtanerceptEtanercept may increase the nephrotoxic activities of Tacrolimus.Approved, Investigational
EthanolEthanol can cause an increase in the absorption of Tacrolimus resulting in an increased serum concentration and potentially a worsening of adverse effects.Approved
EthenzamideEthenzamide may increase the nephrotoxic activities of Tacrolimus.Experimental
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Tacrolimus.Approved
EtodolacEtodolac may increase the nephrotoxic activities of Tacrolimus.Approved, Investigational, Vet Approved
EtofenamateEtofenamate may increase the nephrotoxic activities of Tacrolimus.Approved
EtoposideThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Etoposide.Approved
EtoricoxibEtoricoxib may increase the nephrotoxic activities of Tacrolimus.Approved, Investigational
EtravirineThe serum concentration of Tacrolimus can be increased when it is combined with Etravirine.Approved
Evening primrose oilEvening primrose oil may increase the nephrotoxic activities of Tacrolimus.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Tacrolimus.Approved
ExenatideThe therapeutic efficacy of Exenatide can be decreased when used in combination with Tacrolimus.Approved, Investigational
exisulindexisulind may increase the nephrotoxic activities of Tacrolimus.Investigational
EzetimibeThe serum concentration of Ezetimibe can be decreased when it is combined with Tacrolimus.Approved
FaldaprevirThe metabolism of Tacrolimus can be decreased when combined with Faldaprevir.Investigational
FelbinacFelbinac may increase the nephrotoxic activities of Tacrolimus.Experimental
FenbufenFenbufen may increase the nephrotoxic activities of Tacrolimus.Approved
FenfluramineThe metabolism of Tacrolimus can be decreased when combined with Fenfluramine.Illicit, Withdrawn
FenofibrateTacrolimus may increase the nephrotoxic activities of Fenofibrate.Approved
FenoprofenFenoprofen may increase the nephrotoxic activities of Tacrolimus.Approved
FentanylThe serum concentration of Tacrolimus can be increased when it is combined with Fentanyl.Approved, Illicit, Investigational, Vet Approved
FentiazacFentiazac may increase the nephrotoxic activities of Tacrolimus.Experimental
FenticonazoleThe metabolism of Tacrolimus can be decreased when combined with Fenticonazole.Experimental
FeprazoneFeprazone may increase the nephrotoxic activities of Tacrolimus.Experimental
Ferulic acidFerulic acid may increase the nephrotoxic activities of Tacrolimus.Experimental
FesoterodineThe serum concentration of Fesoterodine can be decreased when it is combined with Tacrolimus.Approved
FexofenadineThe serum concentration of Fexofenadine can be decreased when it is combined with Tacrolimus.Approved
FidaxomicinThe serum concentration of Fidaxomicin can be decreased when it is combined with Tacrolimus.Approved
FingolimodTacrolimus may increase the immunosuppressive activities of Fingolimod.Approved, Investigational
FloctafenineFloctafenine may increase the nephrotoxic activities of Tacrolimus.Approved, Withdrawn
FloxuridineThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Floxuridine.Approved
FluconazoleThe serum concentration of Tacrolimus can be increased when it is combined with Fluconazole.Approved
FlucytosineThe metabolism of Tacrolimus can be decreased when combined with Flucytosine.Approved
FludarabineThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Fludarabine.Approved
FludrocortisoneThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Fludrocortisone.Approved
FlunixinFlunixin may increase the nephrotoxic activities of Tacrolimus.Vet Approved
FlunoxaprofenFlunoxaprofen may increase the nephrotoxic activities of Tacrolimus.Experimental
FluorouracilThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Fluorouracil.Approved
FluoxetineThe metabolism of Tacrolimus can be decreased when combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe serum concentration of Tacrolimus can be increased when it is combined with Flupentixol.Approved, Withdrawn
FluphenazineThe serum concentration of Tacrolimus can be increased when it is combined with Fluphenazine.Approved
FlurazepamThe serum concentration of Tacrolimus can be increased when it is combined with Flurazepam.Approved, Illicit
FlurbiprofenFlurbiprofen may increase the nephrotoxic activities of Tacrolimus.Approved, Investigational
Fluticasone furoateThe serum concentration of Fluticasone furoate can be decreased when it is combined with Tacrolimus.Approved
FlutrimazoleThe metabolism of Tacrolimus can be decreased when combined with Flutrimazole.Experimental
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Tacrolimus.Approved
FluvoxamineThe metabolism of Tacrolimus can be decreased when combined with Fluvoxamine.Approved, Investigational
FosamprenavirThe metabolism of Tacrolimus can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Tacrolimus can be increased when it is combined with Fosaprepitant.Approved
FoscarnetFoscarnet may increase the nephrotoxic activities of Tacrolimus.Approved
FosinoprilThe metabolism of Tacrolimus can be decreased when combined with Fosinopril.Approved
FosphenytoinThe serum concentration of Tacrolimus can be decreased when it is combined with Fosphenytoin.Approved
Fusidic AcidThe serum concentration of Tacrolimus can be increased when it is combined with Fusidic Acid.Approved
G17DTThe therapeutic efficacy of G17DT can be decreased when used in combination with Tacrolimus.Investigational
GabexateThe metabolism of Tacrolimus can be decreased when combined with Gabexate.Investigational
Gallium nitrateThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Gallium nitrate.Approved, Investigational
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with Tacrolimus.Approved, Investigational
GeldanamycinThe metabolism of Tacrolimus can be decreased when combined with Geldanamycin.Experimental
GemcitabineThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Gemcitabine.Approved
Gemtuzumab ozogamicinThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Gemtuzumab ozogamicin.Approved
GenisteinThe serum concentration of Tacrolimus can be increased when it is combined with Genistein.Investigational
GI-5005The therapeutic efficacy of GI-5005 can be decreased when used in combination with Tacrolimus.Investigational
Glatiramer AcetateThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Glatiramer Acetate.Approved, Investigational
GlecaprevirThe serum concentration of Glecaprevir can be decreased when it is combined with Tacrolimus.Approved
GlibornurideThe therapeutic efficacy of Glibornuride can be decreased when used in combination with Tacrolimus.Withdrawn
GliclazideThe therapeutic efficacy of Gliclazide can be decreased when used in combination with Tacrolimus.Approved
GlimepirideThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Glimepiride.Approved
GlipizideThe therapeutic efficacy of Glipizide can be decreased when used in combination with Tacrolimus.Approved
GliquidoneThe therapeutic efficacy of Gliquidone can be decreased when used in combination with Tacrolimus.Approved
GlyburideThe serum concentration of Tacrolimus can be increased when it is combined with Glyburide.Approved
GlycerinThe serum concentration of Tacrolimus can be increased when it is combined with Glycerin.Approved, Investigational
GlyphosateThe metabolism of Tacrolimus can be decreased when combined with Glyphosate.Experimental
GM6001The metabolism of Tacrolimus can be decreased when combined with GM6001.Experimental
GolimumabThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Golimumab.Approved
Gramicidin DThe serum concentration of Tacrolimus can be increased when it is combined with Gramicidin D.Approved
GrazoprevirThe serum concentration of Grazoprevir can be decreased when it is combined with Tacrolimus.Approved
GrepafloxacinThe serum concentration of Grepafloxacin can be decreased when it is combined with Tacrolimus.Withdrawn
GriseofulvinThe metabolism of Tacrolimus can be decreased when combined with Griseofulvin.Approved, Vet Approved
GS 0573The risk or severity of adverse effects can be increased when Tacrolimus is combined with GS 0573.Investigational
GuacetisalGuacetisal may increase the nephrotoxic activities of Tacrolimus.Experimental
GusperimusThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Gusperimus.Investigational
HachimycinThe metabolism of Tacrolimus can be decreased when combined with Hachimycin.Experimental
HaloperidolThe serum concentration of Haloperidol can be decreased when it is combined with Tacrolimus.Approved
HaloproginThe metabolism of Tacrolimus can be decreased when combined with Haloprogin.Approved, Withdrawn
HexetidineThe metabolism of Tacrolimus can be decreased when combined with Hexetidine.Approved
HigenamineHigenamine may increase the nephrotoxic activities of Tacrolimus.Investigational
Human C1-esterase inhibitorThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Human C1-esterase inhibitor.Approved
HydrocortisoneThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Hydrocortisone.Approved, Vet Approved
HydroxyureaThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Hydroxyurea.Approved
HypericinThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Hypericin.Investigational
Ibritumomab tiuxetanThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Ibritumomab tiuxetan.Approved
IbrutinibThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Ibrutinib.Approved
IbuprofenIbuprofen may increase the nephrotoxic activities of Tacrolimus.Approved
IbuproxamIbuproxam may increase the nephrotoxic activities of Tacrolimus.Withdrawn
IcatibantIcatibant may increase the nephrotoxic activities of Tacrolimus.Approved
IdarubicinThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Idarubicin.Approved
IdelalisibThe serum concentration of Tacrolimus can be increased when it is combined with Idelalisib.Approved
IdraparinuxThe metabolism of Tacrolimus can be decreased when combined with Idraparinux.Investigational
IfosfamideThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Ifosfamide.Approved
ImatinibThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Imatinib.Approved
ImidaprilThe metabolism of Tacrolimus can be decreased when combined with Imidapril.Investigational
Imidazole salicylateImidazole salicylate may increase the nephrotoxic activities of Tacrolimus.Experimental
ImipramineThe serum concentration of Imipramine can be decreased when it is combined with Tacrolimus.Approved
ImiquimodThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Imiquimod.Approved, Investigational
IndacaterolThe serum concentration of Indacaterol can be decreased when it is combined with Tacrolimus.Approved
IndalpineThe metabolism of Tacrolimus can be decreased when combined with Indalpine.Investigational, Withdrawn
IndinavirThe metabolism of Tacrolimus can be decreased when combined with Indinavir.Approved
IndobufenIndobufen may increase the nephrotoxic activities of Tacrolimus.Investigational
IndomethacinIndomethacin may increase the nephrotoxic activities of Tacrolimus.Approved, Investigational
IndoprofenIndoprofen may increase the nephrotoxic activities of Tacrolimus.Withdrawn
InfliximabThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Infliximab.Approved
INGN 201The therapeutic efficacy of INGN 201 can be decreased when used in combination with Tacrolimus.Investigational
INGN 225The therapeutic efficacy of INGN 225 can be decreased when used in combination with Tacrolimus.Investigational
Inotuzumab ozogamicinThe serum concentration of Inotuzumab ozogamicin can be decreased when it is combined with Tacrolimus.Approved
Insulin AspartThe therapeutic efficacy of Insulin Aspart can be decreased when used in combination with Tacrolimus.Approved
Insulin DetemirThe therapeutic efficacy of Insulin Detemir can be decreased when used in combination with Tacrolimus.Approved
Insulin GlargineThe therapeutic efficacy of Insulin Glargine can be decreased when used in combination with Tacrolimus.Approved
Insulin GlulisineThe therapeutic efficacy of Insulin Glulisine can be decreased when used in combination with Tacrolimus.Approved
Insulin HumanThe therapeutic efficacy of Insulin Human can be decreased when used in combination with Tacrolimus.Approved, Investigational
Insulin LisproThe therapeutic efficacy of Insulin Lispro can be decreased when used in combination with Tacrolimus.Approved
Insulin PorkThe therapeutic efficacy of Insulin Pork can be decreased when used in combination with Tacrolimus.Approved
IrinotecanThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Irinotecan.Approved, Investigational
IsavuconazoniumThe metabolism of Tacrolimus can be decreased when combined with Isavuconazonium.Approved, Investigational
IsoconazoleThe metabolism of Tacrolimus can be decreased when combined with Isoconazole.Approved
IsoflurophateThe metabolism of Tacrolimus can be decreased when combined with Isoflurophate.Approved, Withdrawn
IsoxicamIsoxicam may increase the nephrotoxic activities of Tacrolimus.Withdrawn
IsradipineThe serum concentration of Tacrolimus can be increased when it is combined with Isradipine.Approved
ItraconazoleThe serum concentration of Tacrolimus can be increased when it is combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Tacrolimus can be increased when it is combined with Ivacaftor.Approved
IvermectinThe serum concentration of Ivermectin can be decreased when it is combined with Tacrolimus.Approved, Vet Approved
IxazomibThe metabolism of Tacrolimus can be decreased when combined with Ixazomib.Approved
JosamycinThe serum concentration of Tacrolimus can be increased when it is combined with Josamycin.Approved
KebuzoneKebuzone may increase the nephrotoxic activities of Tacrolimus.Experimental
KetamineThe serum concentration of Tacrolimus can be increased when it is combined with Ketamine.Approved, Vet Approved
KetazolamThe serum concentration of Ketazolam can be decreased when it is combined with Tacrolimus.Approved
KetoconazoleThe serum concentration of Tacrolimus can be increased when it is combined with Ketoconazole.Approved, Investigational
KetoprofenKetoprofen may increase the nephrotoxic activities of Tacrolimus.Approved, Vet Approved
KetorolacKetorolac may increase the nephrotoxic activities of Tacrolimus.Approved
KitasamycinThe serum concentration of Tacrolimus can be increased when it is combined with Kitasamycin.Experimental
L-PhenylalanineThe risk or severity of adverse effects can be increased when Tacrolimus is combined with L-Phenylalanine.Approved, Nutraceutical
LamivudineThe serum concentration of Lamivudine can be decreased when it is combined with Tacrolimus.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be decreased when it is combined with Tacrolimus.Approved, Investigational
LansoprazoleThe serum concentration of Tacrolimus can be increased when it is combined with Lansoprazole.Approved, Investigational
LapatinibThe serum concentration of Tacrolimus can be increased when it is combined with Lapatinib.Approved, Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Tacrolimus.Approved
LeflunomideThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Leflunomide.Approved, Investigational
LenalidomideThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Lenalidomide.Approved
LenvatinibThe serum concentration of Lenvatinib can be decreased when it is combined with Tacrolimus.Approved
LepirudinThe metabolism of Tacrolimus can be decreased when combined with Lepirudin.Approved
LetaxabanThe metabolism of Tacrolimus can be decreased when combined with Letaxaban.Investigational
LevetiracetamThe serum concentration of Levetiracetam can be decreased when it is combined with Tacrolimus.Approved, Investigational
LevofloxacinLevofloxacin may increase the QTc-prolonging activities of Tacrolimus.Approved, Investigational
LevomilnacipranThe metabolism of Tacrolimus can be decreased when combined with Levomilnacipran.Approved
LevothyroxineThe serum concentration of Tacrolimus can be decreased when it is combined with Levothyroxine.Approved
LidocaineThe serum concentration of Tacrolimus can be increased when it is combined with Lidocaine.Approved, Vet Approved
LinagliptinThe serum concentration of Linagliptin can be decreased when it is combined with Tacrolimus.Approved
LiothyronineThe serum concentration of Tacrolimus can be decreased when it is combined with Liothyronine.Approved, Vet Approved
LiotrixThe serum concentration of Tacrolimus can be decreased when it is combined with Liotrix.Approved
LiraglutideThe therapeutic efficacy of Liraglutide can be decreased when used in combination with Tacrolimus.Approved
LisinoprilThe metabolism of Tacrolimus can be decreased when combined with Lisinopril.Approved, Investigational
LisofyllineLisofylline may increase the nephrotoxic activities of Tacrolimus.Investigational
LisurideThe risk or severity of adverse effects can be increased when Lisuride is combined with Tacrolimus.Approved
LomitapideThe serum concentration of Tacrolimus can be increased when it is combined with Lomitapide.Approved
LomustineThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Lomustine.Approved
LonazolacLonazolac may increase the nephrotoxic activities of Tacrolimus.Experimental
LoperamideThe serum concentration of Loperamide can be decreased when it is combined with Tacrolimus.Approved
LopinavirThe metabolism of Tacrolimus can be decreased when combined with Lopinavir.Approved
LoratadineThe serum concentration of Tacrolimus can be increased when it is combined with Loratadine.Approved
LornoxicamLornoxicam may increase the nephrotoxic activities of Tacrolimus.Approved
LosartanThe serum concentration of Losartan can be decreased when it is combined with Tacrolimus.Approved
LovastatinThe metabolism of Tacrolimus can be decreased when combined with Lovastatin.Approved, Investigational
LoxoprofenLoxoprofen may increase the nephrotoxic activities of Tacrolimus.Approved
LuliconazoleThe serum concentration of Tacrolimus can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Tacrolimus can be decreased when it is combined with Lumacaftor.Approved
LumiracoxibLumiracoxib may increase the nephrotoxic activities of Tacrolimus.Approved, Investigational
Lysergic Acid DiethylamideThe risk or severity of adverse effects can be increased when Lysergic Acid Diethylamide is combined with Tacrolimus.Illicit, Withdrawn
Magnesium salicylateMagnesium salicylate may increase the nephrotoxic activities of Tacrolimus.Approved
MannitolThe serum concentration of Mannitol can be decreased when it is combined with Tacrolimus.Approved, Investigational
MaprotilineThe serum concentration of Tacrolimus can be increased when it is combined with Maprotiline.Approved
MasoprocolMasoprocol may increase the nephrotoxic activities of Tacrolimus.Approved
MebendazoleThe serum concentration of Tacrolimus can be increased when it is combined with Mebendazole.Approved, Vet Approved
MechlorethamineThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Mechlorethamine.Approved
Meclofenamic acidMeclofenamic acid may increase the nephrotoxic activities of Tacrolimus.Approved, Vet Approved
Mefenamic acidMefenamic acid may increase the nephrotoxic activities of Tacrolimus.Approved
MefloquineThe serum concentration of Tacrolimus can be increased when it is combined with Mefloquine.Approved
Megestrol acetateThe serum concentration of Tacrolimus can be increased when it is combined with Megestrol acetate.Approved, Vet Approved
MelagatranThe metabolism of Tacrolimus can be decreased when combined with Melagatran.Experimental
MeloxicamMeloxicam may increase the nephrotoxic activities of Tacrolimus.Approved, Vet Approved
MelphalanThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Melphalan.Approved
MepartricinThe metabolism of Tacrolimus can be decreased when combined with Mepartricin.Experimental
MepolizumabThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Mepolizumab.Approved, Investigational
MeprobamateThe serum concentration of Tacrolimus can be increased when it is combined with Meprobamate.Approved, Illicit
MercaptopurineThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Mercaptopurine.Approved
MesalazineMesalazine may increase the nephrotoxic activities of Tacrolimus.Approved
MetamizoleMetamizole may increase the nephrotoxic activities of Tacrolimus.Withdrawn
MetergolineThe risk or severity of adverse effects can be increased when Metergoline is combined with Tacrolimus.Experimental
MetforminThe therapeutic efficacy of Metformin can be decreased when used in combination with Tacrolimus.Approved
MethadoneThe serum concentration of Tacrolimus can be increased when it is combined with Methadone.Approved
MethotrexateThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Methotrexate.Approved
MethylergometrineThe risk or severity of adverse effects can be increased when Methylergometrine is combined with Tacrolimus.Approved
MethylprednisoloneThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Methylprednisolone.Approved, Vet Approved
MethysergideThe risk or severity of adverse effects can be increased when Methysergide is combined with Tacrolimus.Approved
MetoprololThe serum concentration of Metoprolol can be decreased when it is combined with Tacrolimus.Approved, Investigational
MevastatinThe metabolism of Tacrolimus can be decreased when combined with Mevastatin.Experimental
MibefradilThe serum concentration of Tacrolimus can be increased when it is combined with Mibefradil.Withdrawn
MicafunginThe metabolism of Tacrolimus can be decreased when combined with Micafungin.Approved, Investigational
MiconazoleThe metabolism of Tacrolimus can be decreased when combined with Miconazole.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Midazolam can be decreased when it is combined with Tacrolimus.Approved, Illicit
MifepristoneMifepristone may increase the QTc-prolonging activities of Tacrolimus.Approved, Investigational
MiglitolThe therapeutic efficacy of Miglitol can be decreased when used in combination with Tacrolimus.Approved
MiglustatThe therapeutic efficacy of Miglustat can be decreased when used in combination with Tacrolimus.Approved
MilnacipranThe metabolism of Tacrolimus can be decreased when combined with Milnacipran.Approved
MiltefosineThe metabolism of Tacrolimus can be decreased when combined with Miltefosine.Approved
MirabegronThe serum concentration of Mirabegron can be decreased when it is combined with Tacrolimus.Approved
MitiglinideThe therapeutic efficacy of Mitiglinide can be decreased when used in combination with Tacrolimus.Approved, Investigational
MitomycinThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Mitomycin.Approved
MitotaneThe serum concentration of Tacrolimus can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Mitoxantrone.Approved, Investigational
MizoribineMizoribine may increase the nephrotoxic activities of Tacrolimus.Investigational
MoexiprilThe metabolism of Tacrolimus can be decreased when combined with Moexipril.Approved
MofebutazoneMofebutazone may increase the nephrotoxic activities of Tacrolimus.Experimental
MonensinThe metabolism of Tacrolimus can be decreased when combined with Monensin.Vet Approved
MorphineThe serum concentration of Morphine can be decreased when it is combined with Tacrolimus.Approved, Investigational
MuromonabThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Muromonab.Approved, Investigational
Mycophenolate mofetilMycophenolate mofetil may increase the nephrotoxic activities of Tacrolimus.Approved, Investigational
Mycophenolic acidMycophenolic acid may increase the nephrotoxic activities of Tacrolimus.Approved
MyxothiazolThe metabolism of Tacrolimus can be decreased when combined with Myxothiazol.Experimental
N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-ProlineThe metabolism of Tacrolimus can be decreased when combined with N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline.Experimental
NabumetoneNabumetone may increase the nephrotoxic activities of Tacrolimus.Approved
NadololThe serum concentration of Nadolol can be decreased when it is combined with Tacrolimus.Approved
NafamostatThe metabolism of Tacrolimus can be decreased when combined with Nafamostat.Approved, Investigational
NaftifineThe metabolism of Tacrolimus can be decreased when combined with Naftifine.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Tacrolimus.Approved
NaloxoneThe serum concentration of Naloxone can be decreased when it is combined with Tacrolimus.Approved, Vet Approved
NaltrexoneThe serum concentration of Tacrolimus can be increased when it is combined with Naltrexone.Approved, Investigational, Vet Approved
NaproxenNaproxen may increase the nephrotoxic activities of Tacrolimus.Approved, Vet Approved
NaringeninThe serum concentration of Tacrolimus can be increased when it is combined with Naringenin.Experimental
NatalizumabThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Natalizumab.Approved, Investigational
NatamycinThe metabolism of Tacrolimus can be decreased when combined with Natamycin.Approved
NateglinideThe therapeutic efficacy of Nateglinide can be decreased when used in combination with Tacrolimus.Approved, Investigational
NefazodoneThe metabolism of Tacrolimus can be decreased when combined with Nefazodone.Approved, Withdrawn
NelarabineThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Nelarabine.Approved, Investigational
NelfinavirThe metabolism of Tacrolimus can be decreased when combined with Nelfinavir.Approved
NeostigmineThe serum concentration of Tacrolimus can be increased when it is combined with Neostigmine.Approved, Vet Approved
NepafenacNepafenac may increase the nephrotoxic activities of Tacrolimus.Approved
NetupitantThe serum concentration of Tacrolimus can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Tacrolimus can be increased when combined with Nevirapine.Approved
NicardipineThe serum concentration of Tacrolimus can be increased when it is combined with Nicardipine.Approved
NicergolineThe risk or severity of adverse effects can be increased when Nicergoline is combined with Tacrolimus.Approved
NifedipineThe serum concentration of Tacrolimus can be increased when it is combined with Nifedipine.Approved
NifenazoneNifenazone may increase the nephrotoxic activities of Tacrolimus.Experimental
Niflumic AcidNiflumic Acid may increase the nephrotoxic activities of Tacrolimus.Approved
NifuratelThe metabolism of Tacrolimus can be decreased when combined with Nifuratel.Experimental
Nikkomycin ZThe metabolism of Tacrolimus can be decreased when combined with Nikkomycin Z.Investigational
NilotinibThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Nilotinib.Approved, Investigational
NimesulideNimesulide may increase the nephrotoxic activities of Tacrolimus.Approved, Withdrawn
NimodipineThe serum concentration of Tacrolimus can be increased when it is combined with Nimodipine.Approved
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Tacrolimus.Approved
NitrazepamThe serum concentration of Tacrolimus can be increased when it is combined with Nitrazepam.Approved
NitrendipineThe serum concentration of Tacrolimus can be increased when it is combined with Nitrendipine.Approved
NitroaspirinThe metabolism of Tacrolimus can be decreased when combined with Nitroaspirin.Investigational
NitroxolineThe metabolism of Tacrolimus can be decreased when combined with Nitroxoline.Approved
NizatidineThe serum concentration of Nizatidine can be decreased when it is combined with Tacrolimus.Approved
NorethisteroneThe serum concentration of Tacrolimus can be decreased when it is combined with Norethisterone.Approved
NystatinThe metabolism of Tacrolimus can be decreased when combined with Nystatin.Approved, Vet Approved
ObinutuzumabThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Obinutuzumab.Approved
OdanacatibThe serum concentration of Odanacatib can be decreased when it is combined with Tacrolimus.Investigational
OlanzapineThe metabolism of Tacrolimus can be decreased when combined with Olanzapine.Approved, Investigational
OlaparibThe metabolism of Tacrolimus can be decreased when combined with Olaparib.Approved
OleandomycinThe serum concentration of Tacrolimus can be increased when it is combined with Oleandomycin.Vet Approved
OlopatadineOlopatadine may increase the nephrotoxic activities of Tacrolimus.Approved
OlsalazineOlsalazine may increase the nephrotoxic activities of Tacrolimus.Approved
OmapatrilatThe metabolism of Tacrolimus can be decreased when combined with Omapatrilat.Investigational
OmbitasvirThe serum concentration of Tacrolimus can be increased when it is combined with Ombitasvir.Approved
OmeprazoleThe serum concentration of Tacrolimus can be increased when it is combined with Omeprazole.Approved, Investigational, Vet Approved
OmoconazoleThe metabolism of Tacrolimus can be decreased when combined with Omoconazole.Experimental
OrgoteinOrgotein may increase the nephrotoxic activities of Tacrolimus.Vet Approved
OsimertinibThe serum concentration of Tacrolimus can be increased when it is combined with Osimertinib.Approved
OtamixabanThe metabolism of Tacrolimus can be decreased when combined with Otamixaban.Investigational
OxaliplatinThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Oxaliplatin.Approved, Investigational
OxaprozinOxaprozin may increase the nephrotoxic activities of Tacrolimus.Approved
OxiconazoleThe metabolism of Tacrolimus can be decreased when combined with Oxiconazole.Approved
OxyphenbutazoneOxyphenbutazone may increase the nephrotoxic activities of Tacrolimus.Withdrawn
P-NitrophenolThe serum concentration of Tacrolimus can be increased when it is combined with P-Nitrophenol.Experimental
PaclitaxelThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Paclitaxel.Approved, Vet Approved
pafuramidineThe metabolism of Tacrolimus can be decreased when combined with pafuramidine.Investigational
PalbociclibThe serum concentration of Tacrolimus can be increased when it is combined with Palbociclib.Approved
Palmitic AcidThe serum concentration of Tacrolimus can be increased when it is combined with Palmitic Acid.Experimental
PanobinostatThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Panobinostat.Approved, Investigational
PantoprazoleThe serum concentration of Tacrolimus can be increased when it is combined with Pantoprazole.Approved
PaquinimodThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Paquinimod.Investigational
ParecoxibParecoxib may increase the nephrotoxic activities of Tacrolimus.Approved
ParitaprevirThe serum concentration of Tacrolimus can be increased when it is combined with Paritaprevir.Approved
ParoxetineThe metabolism of Tacrolimus can be decreased when combined with Paroxetine.Approved, Investigational
ParthenolideParthenolide may increase the nephrotoxic activities of Tacrolimus.Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Tacrolimus.Approved
PegaspargaseThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Pegaspargase.Approved, Investigational
PemetrexedThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Pemetrexed.Approved, Investigational
PentamidineThe metabolism of Tacrolimus can be decreased when combined with Pentamidine.Approved
PentobarbitalThe metabolism of Tacrolimus can be increased when combined with Pentobarbital.Approved, Vet Approved
PentostatinThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Pentostatin.Approved, Investigational
PergolideThe risk or severity of adverse effects can be increased when Pergolide is combined with Tacrolimus.Approved, Vet Approved, Withdrawn
PerindoprilThe metabolism of Tacrolimus can be decreased when combined with Perindopril.Approved
PhenforminThe therapeutic efficacy of Phenformin can be decreased when used in combination with Tacrolimus.Approved, Withdrawn
PhenobarbitalThe metabolism of Tacrolimus can be increased when combined with Phenobarbital.Approved
PhenylbutazonePhenylbutazone may increase the nephrotoxic activities of Tacrolimus.Approved, Vet Approved
PhenytoinThe serum concentration of Tacrolimus can be decreased when it is combined with Phenytoin.Approved, Vet Approved
PhosphoramidonThe metabolism of Tacrolimus can be decreased when combined with Phosphoramidon.Experimental
PibrentasvirThe serum concentration of Pibrentasvir can be decreased when it is combined with Tacrolimus.Approved
PimecrolimusPimecrolimus may increase the nephrotoxic activities of Tacrolimus.Approved, Investigational
PimozideThe serum concentration of Tacrolimus can be increased when it is combined with Pimozide.Approved
PioglitazoneThe therapeutic efficacy of Pioglitazone can be decreased when used in combination with Tacrolimus.Approved, Investigational
PirarubicinThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Pirarubicin.Investigational
PirfenidonePirfenidone may increase the nephrotoxic activities of Tacrolimus.Investigational
PiroxicamPiroxicam may increase the nephrotoxic activities of Tacrolimus.Approved, Investigational
PirprofenPirprofen may increase the nephrotoxic activities of Tacrolimus.Experimental
PitavastatinThe serum concentration of Pitavastatin can be decreased when it is combined with Tacrolimus.Approved
Platelet Activating FactorThe serum concentration of Tacrolimus can be decreased when it is combined with Platelet Activating Factor.Experimental
PomalidomideThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Pomalidomide.Approved
PonatinibThe serum concentration of Ponatinib can be decreased when it is combined with Tacrolimus.Approved
PosaconazoleThe serum concentration of Tacrolimus can be increased when it is combined with Posaconazole.Approved, Investigational, Vet Approved
PralatrexateThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Pralatrexate.Approved
PramlintideThe therapeutic efficacy of Pramlintide can be decreased when used in combination with Tacrolimus.Approved, Investigational
PranoprofenPranoprofen may increase the nephrotoxic activities of Tacrolimus.Experimental
PravastatinThe serum concentration of Pravastatin can be decreased when it is combined with Tacrolimus.Approved
PrazosinThe serum concentration of Prazosin can be decreased when it is combined with Tacrolimus.Approved
PrednisoloneThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Prednisolone.Approved, Vet Approved
PrednisoneThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Prednisone.Approved, Vet Approved
PrimidoneThe metabolism of Tacrolimus can be increased when combined with Primidone.Approved, Vet Approved
PrinomastatThe metabolism of Tacrolimus can be decreased when combined with Prinomastat.Investigational
ProbenecidThe serum concentration of Tacrolimus can be increased when it is combined with Probenecid.Approved
ProcarbazineThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Procarbazine.Approved
ProgesteroneThe serum concentration of Tacrolimus can be decreased when it is combined with Progesterone.Approved, Vet Approved
ProglumetacinProglumetacin may increase the nephrotoxic activities of Tacrolimus.Experimental
PromethazineThe serum concentration of Tacrolimus can be increased when it is combined with Promethazine.Approved
PropacetamolPropacetamol may increase the nephrotoxic activities of Tacrolimus.Approved
PropafenoneThe serum concentration of Tacrolimus can be increased when it is combined with Propafenone.Approved
PropranololThe serum concentration of Propranolol can be decreased when it is combined with Tacrolimus.Approved, Investigational
PropyphenazonePropyphenazone may increase the nephrotoxic activities of Tacrolimus.Experimental
ProquazoneProquazone may increase the nephrotoxic activities of Tacrolimus.Experimental
ProtriptylineThe serum concentration of Tacrolimus can be increased when it is combined with Protriptyline.Approved
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Tacrolimus.Approved
PTC299PTC299 may increase the nephrotoxic activities of Tacrolimus.Investigational
PyrrolnitrinThe metabolism of Tacrolimus can be decreased when combined with Pyrrolnitrin.Experimental
QuercetinThe serum concentration of Tacrolimus can be increased when it is combined with Quercetin.Experimental
QuetiapineThe serum concentration of Quetiapine can be decreased when it is combined with Tacrolimus.Approved
QuinacrineThe serum concentration of Tacrolimus can be increased when it is combined with Quinacrine.Approved
QuinaprilThe metabolism of Tacrolimus can be decreased when combined with Quinapril.Approved, Investigational
QuinidineThe serum concentration of Quinidine can be decreased when it is combined with Tacrolimus.Approved
QuinineThe serum concentration of Quinine can be decreased when it is combined with Tacrolimus.Approved
RabeprazoleThe serum concentration of Tacrolimus can be increased when it is combined with Rabeprazole.Approved, Investigational
Rabies virus inactivated antigen, AThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Rabies virus inactivated antigen, A.Approved
Rabies virus inactivated antigen, AThe therapeutic efficacy of Rabies virus inactivated antigen, A can be decreased when used in combination with Tacrolimus.Approved
RacecadotrilThe metabolism of Tacrolimus can be decreased when combined with Racecadotril.Investigational
RadicicolThe metabolism of Tacrolimus can be decreased when combined with Radicicol.Experimental
RamiprilThe metabolism of Tacrolimus can be decreased when combined with Ramipril.Approved
RanitidineThe serum concentration of Ranitidine can be decreased when it is combined with Tacrolimus.Approved
ReboxetineThe serum concentration of Tacrolimus can be increased when it is combined with Reboxetine.Approved, Investigational
RegorafenibThe serum concentration of Tacrolimus can be increased when it is combined with Regorafenib.Approved
RemikirenThe metabolism of Tacrolimus can be decreased when combined with Remikiren.Approved
RepaglinideThe therapeutic efficacy of Repaglinide can be decreased when used in combination with Tacrolimus.Approved, Investigational
ReserpineThe serum concentration of Tacrolimus can be decreased when it is combined with Reserpine.Approved
ResveratrolResveratrol may increase the nephrotoxic activities of Tacrolimus.Experimental, Investigational
RifabutinThe serum concentration of Tacrolimus can be decreased when it is combined with Rifabutin.Approved
RifampicinThe serum concentration of Tacrolimus can be decreased when it is combined with Rifampicin.Approved
RifapentineThe serum concentration of Tacrolimus can be decreased when it is combined with Rifapentine.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Tacrolimus.Approved, Investigational
RilonaceptThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Rilonacept.Approved
RilpivirineThe serum concentration of Tacrolimus can be increased when it is combined with Rilpivirine.Approved
RindopepimutThe therapeutic efficacy of Rindopepimut can be decreased when used in combination with Tacrolimus.Investigational
RisperidoneThe serum concentration of Risperidone can be decreased when it is combined with Tacrolimus.Approved, Investigational
RitonavirThe serum concentration of Tacrolimus can be increased when it is combined with Ritonavir.Approved, Investigational
RituximabThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Rituximab.Approved
RivaroxabanThe metabolism of Tacrolimus can be decreased when combined with Rivaroxaban.Approved
RofecoxibRofecoxib may increase the nephrotoxic activities of Tacrolimus.Investigational, Withdrawn
RoflumilastRoflumilast may increase the immunosuppressive activities of Tacrolimus.Approved
RolapitantThe serum concentration of Tacrolimus can be increased when it is combined with Rolapitant.Approved
RomidepsinThe serum concentration of Romidepsin can be decreased when it is combined with Tacrolimus.Approved, Investigational
RosiglitazoneThe therapeutic efficacy of Rosiglitazone can be decreased when used in combination with Tacrolimus.Approved, Investigational
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Tacrolimus.Approved
Rotavirus VaccineThe therapeutic efficacy of Rotavirus Vaccine can be decreased when used in combination with Tacrolimus.Approved
Rubella virus vaccineThe therapeutic efficacy of Rubella virus vaccine can be decreased when used in combination with Tacrolimus.Approved
RuxolitinibThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Ruxolitinib.Approved
S-3304The metabolism of Tacrolimus can be decreased when combined with S-3304.Investigational
SalicylamideSalicylamide may increase the nephrotoxic activities of Tacrolimus.Approved
Salicylhydroxamic AcidThe metabolism of Tacrolimus can be decreased when combined with Salicylhydroxamic Acid.Experimental
Salicylic acidThe metabolism of Tacrolimus can be decreased when combined with Salicylic acid.Approved, Vet Approved
SalsalateSalsalate may increase the nephrotoxic activities of Tacrolimus.Approved
SaquinavirThe metabolism of Tacrolimus can be decreased when combined with Saquinavir.Approved, Investigational
SaxagliptinThe metabolism of Tacrolimus can be decreased when combined with Saxagliptin.Approved
ScopolamineThe serum concentration of Tacrolimus can be increased when it is combined with Scopolamine.Approved
SecukinumabThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Secukinumab.Approved
SelegilineThe serum concentration of Tacrolimus can be increased when it is combined with Selegiline.Approved, Investigational, Vet Approved
SelexipagThe serum concentration of Selexipag can be decreased when it is combined with Tacrolimus.Approved
SemapimodSemapimod may increase the nephrotoxic activities of Tacrolimus.Investigational
SeocalcitolThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Seocalcitol.Experimental
SeratrodastSeratrodast may increase the nephrotoxic activities of Tacrolimus.Approved
SerrapeptaseSerrapeptase may increase the nephrotoxic activities of Tacrolimus.Investigational
SertaconazoleThe metabolism of Tacrolimus can be decreased when combined with Sertaconazole.Approved
SertralineThe metabolism of Tacrolimus can be decreased when combined with Sertraline.Approved
SevelamerThe serum concentration of Tacrolimus can be decreased when it is combined with Sevelamer.Approved
SildenafilThe metabolism of Tacrolimus can be decreased when combined with Sildenafil.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Tacrolimus.Approved
SiltuximabThe serum concentration of Tacrolimus can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe metabolism of Tacrolimus can be decreased when combined with Simeprevir.Approved
SimvastatinThe serum concentration of Tacrolimus can be increased when it is combined with Simvastatin.Approved
SinefunginThe metabolism of Tacrolimus can be decreased when combined with Sinefungin.Experimental
Sipuleucel-TThe therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Tacrolimus.Approved
SirolimusThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Sirolimus.Approved, Investigational
SitagliptinThe metabolism of Tacrolimus can be decreased when combined with Sitagliptin.Approved, Investigational
SivelestatThe metabolism of Tacrolimus can be decreased when combined with Sivelestat.Investigational
SofosbuvirThe serum concentration of Sofosbuvir can be decreased when it is combined with Tacrolimus.Approved
SolithromycinThe serum concentration of Tacrolimus can be increased when it is combined with Solithromycin.Investigational
SorafenibThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Sorafenib.Approved, Investigational
SotagliflozinThe therapeutic efficacy of Sotagliflozin can be decreased when used in combination with Tacrolimus.Investigational
SparfloxacinThe serum concentration of Sparfloxacin can be decreased when it is combined with Tacrolimus.Approved
SphingosineThe serum concentration of Sphingosine can be decreased when it is combined with Tacrolimus.Experimental
SpiraprilThe metabolism of Tacrolimus can be decreased when combined with Spirapril.Approved
SpironolactoneSpironolactone may increase the hyperkalemic activities of Tacrolimus.Approved
SRP 299The therapeutic efficacy of SRP 299 can be decreased when used in combination with Tacrolimus.Investigational
SRT501SRT501 may increase the nephrotoxic activities of Tacrolimus.Investigational
StaurosporineThe serum concentration of Tacrolimus can be increased when it is combined with Staurosporine.Experimental
SteproninThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Stepronin.Approved
StiripentolThe serum concentration of Tacrolimus can be increased when it is combined with Stiripentol.Approved
StreptozocinThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Streptozocin.Approved
SulconazoleThe metabolism of Tacrolimus can be decreased when combined with Sulconazole.Approved
SulfasalazineSulfasalazine may increase the nephrotoxic activities of Tacrolimus.Approved
SulfinpyrazoneThe serum concentration of Tacrolimus can be increased when it is combined with Sulfinpyrazone.Approved
SulfisoxazoleThe metabolism of Tacrolimus can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SulindacSulindac may increase the nephrotoxic activities of Tacrolimus.Approved
SulodexideThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Tacrolimus.Approved, Investigational
SumatriptanThe serum concentration of Tacrolimus can be increased when it is combined with Sumatriptan.Approved, Investigational
SunitinibThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Sunitinib.Approved, Investigational
SuprofenSuprofen may increase the nephrotoxic activities of Tacrolimus.Approved, Withdrawn
SuxibuzoneSuxibuzone may increase the nephrotoxic activities of Tacrolimus.Experimental
TacrineThe serum concentration of Tacrolimus can be increased when it is combined with Tacrine.Withdrawn
TamoxifenThe serum concentration of Tamoxifen can be decreased when it is combined with Tacrolimus.Approved
TarenflurbilTarenflurbil may increase the nephrotoxic activities of Tacrolimus.Investigational
Taurocholic AcidThe serum concentration of Taurocholic Acid can be decreased when it is combined with Tacrolimus.Experimental
TavaboroleThe metabolism of Tacrolimus can be decreased when combined with Tavaborole.Approved
TecemotideThe therapeutic efficacy of Tecemotide can be decreased when used in combination with Tacrolimus.Investigational
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Tacrolimus.Approved
TelaprevirThe serum concentration of Tacrolimus can be increased when it is combined with Telaprevir.Withdrawn
TelithromycinThe serum concentration of Tacrolimus can be increased when it is combined with Telithromycin.Approved
TelmisartanThe serum concentration of Tacrolimus can be increased when it is combined with Telmisartan.Approved, Investigational
TemocaprilThe metabolism of Tacrolimus can be decreased when combined with Temocapril.Experimental, Investigational
TemozolomideThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Temozolomide.Approved, Investigational
TemsirolimusThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Temsirolimus.Approved
TenidapTenidap may increase the nephrotoxic activities of Tacrolimus.Experimental
TeniposideThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Teniposide.Approved
TenoxicamTenoxicam may increase the nephrotoxic activities of Tacrolimus.Approved
TepoxalinTepoxalin may increase the nephrotoxic activities of Tacrolimus.Vet Approved
TerazosinThe serum concentration of Tacrolimus can be increased when it is combined with Terazosin.Approved
TerbinafineThe metabolism of Tacrolimus can be decreased when combined with Terbinafine.Approved, Investigational, Vet Approved
TerconazoleThe metabolism of Tacrolimus can be decreased when combined with Terconazole.Approved
TerfenadineThe serum concentration of Tacrolimus can be increased when it is combined with Terfenadine.Withdrawn
TergurideThe risk or severity of adverse effects can be increased when Terguride is combined with Tacrolimus.Experimental
TeriflunomideTeriflunomide may increase the nephrotoxic activities of Tacrolimus.Approved
TesmilifeneThe serum concentration of Tacrolimus can be decreased when it is combined with Tesmilifene.Investigational
TestosteroneThe serum concentration of Tacrolimus can be increased when it is combined with Testosterone.Approved, Investigational
TG4010The therapeutic efficacy of TG4010 can be decreased when used in combination with Tacrolimus.Investigational
ThalidomideThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Thalidomide.Approved, Investigational, Withdrawn
ThiorphanThe metabolism of Tacrolimus can be decreased when combined with Thiorphan.Experimental
ThiotepaThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Thiotepa.Approved
ThymolThe metabolism of Tacrolimus can be decreased when combined with Thymol.Approved
Tiaprofenic acidTiaprofenic acid may increase the nephrotoxic activities of Tacrolimus.Approved
TicagrelorThe serum concentration of Ticagrelor can be decreased when it is combined with Tacrolimus.Approved
TiclopidineThe metabolism of Tacrolimus can be decreased when combined with Ticlopidine.Approved
TimololThe serum concentration of Timolol can be decreased when it is combined with Tacrolimus.Approved
TinoridineTinoridine may increase the nephrotoxic activities of Tacrolimus.Investigational
TioconazoleThe metabolism of Tacrolimus can be decreased when combined with Tioconazole.Approved
TioguanineThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Tioguanine.Approved
TipranavirThe metabolism of Tacrolimus can be decreased when combined with Tipranavir.Approved, Investigational
TocilizumabThe serum concentration of Tacrolimus can be decreased when it is combined with Tocilizumab.Approved
TofacitinibTacrolimus may increase the immunosuppressive activities of Tofacitinib.Approved, Investigational
TolazamideThe therapeutic efficacy of Tolazamide can be decreased when used in combination with Tacrolimus.Approved
TolbutamideThe therapeutic efficacy of Tolbutamide can be decreased when used in combination with Tacrolimus.Approved
TolciclateThe metabolism of Tacrolimus can be decreased when combined with Tolciclate.Experimental
Tolfenamic AcidTolfenamic Acid may increase the nephrotoxic activities of Tacrolimus.Approved
TolmetinTolmetin may increase the nephrotoxic activities of Tacrolimus.Approved
TolnaftateThe metabolism of Tacrolimus can be decreased when combined with Tolnaftate.Approved, Vet Approved
TolvaptanThe serum concentration of Tolvaptan can be decreased when it is combined with Tacrolimus.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Tacrolimus.Approved, Investigational
ToremifeneThe serum concentration of Toremifene can be decreased when it is combined with Tacrolimus.Approved, Investigational
TositumomabThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Tositumomab.Approved
TrabectedinThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Trabectedin.Approved, Investigational
TrandolaprilThe metabolism of Tacrolimus can be decreased when combined with Trandolapril.Approved
TranilastTranilast may increase the nephrotoxic activities of Tacrolimus.Approved, Investigational
TrastuzumabTrastuzumab may increase the neutropenic activities of Tacrolimus.Approved, Investigational
Trastuzumab emtansineThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Trastuzumab emtansine.Approved
TrazodoneThe metabolism of Tacrolimus can be decreased when combined with Trazodone.Approved, Investigational
TretinoinThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Tretinoin.Approved, Investigational, Nutraceutical
TriamcinoloneThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Triamcinolone.Approved, Vet Approved
TriamtereneTriamterene may increase the hyperkalemic activities of Tacrolimus.Approved
TribenosideTribenoside may increase the nephrotoxic activities of Tacrolimus.Experimental
TrifluoperazineThe serum concentration of Tacrolimus can be increased when it is combined with Trifluoperazine.Approved
TriflupromazineThe serum concentration of Tacrolimus can be increased when it is combined with Triflupromazine.Approved, Vet Approved
TrimethoprimThe serum concentration of Tacrolimus can be decreased when it is combined with Trimethoprim.Approved, Vet Approved
TrimetrexateThe metabolism of Tacrolimus can be decreased when combined with Trimetrexate.Approved, Investigational
TrimipramineThe serum concentration of Tacrolimus can be increased when it is combined with Trimipramine.Approved
TriptolideTriptolide may increase the nephrotoxic activities of Tacrolimus.Investigational
TrofosfamideThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Trofosfamide.Investigational
TroglitazoneThe therapeutic efficacy of Troglitazone can be decreased when used in combination with Tacrolimus.Withdrawn
TroleandomycinThe serum concentration of Tacrolimus can be increased when it is combined with Troleandomycin.Approved
TylosinThe serum concentration of Tacrolimus can be increased when it is combined with Tylosin.Vet Approved
UbenimexThe metabolism of Tacrolimus can be decreased when combined with Ubenimex.Experimental
UbidecarenoneThe serum concentration of Ubidecarenone can be increased when it is combined with Tacrolimus.Experimental
UlinastatinThe metabolism of Tacrolimus can be decreased when combined with Ulinastatin.Investigational
UlipristalThe serum concentration of Ulipristal can be decreased when it is combined with Tacrolimus.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be decreased when it is combined with Tacrolimus.Approved
UstekinumabThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Ustekinumab.Approved, Investigational
ValdecoxibValdecoxib may increase the nephrotoxic activities of Tacrolimus.Investigational, Withdrawn
VecuroniumThe serum concentration of Vecuronium can be decreased when it is combined with Tacrolimus.Approved
VedolizumabThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Vedolizumab.Approved
VelpatasvirThe serum concentration of Velpatasvir can be decreased when it is combined with Tacrolimus.Approved
VenetoclaxThe serum concentration of Venetoclax can be decreased when it is combined with Tacrolimus.Approved
VenlafaxineThe metabolism of Tacrolimus can be decreased when combined with Venlafaxine.Approved
VilanterolThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Vilanterol.Approved
VilazodoneThe metabolism of Tacrolimus can be decreased when combined with Vilazodone.Approved
VildagliptinThe metabolism of Tacrolimus can be decreased when combined with Vildagliptin.Approved, Investigational
VinblastineThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Vinblastine.Approved
VincristineThe serum concentration of Vincristine can be decreased when it is combined with Tacrolimus.Approved, Investigational
VincristineThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Vincristine.Approved, Investigational
VindesineThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Vindesine.Approved
VinorelbineThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Vinorelbine.Approved, Investigational
VismodegibThe serum concentration of Vismodegib can be decreased when it is combined with Tacrolimus.Approved
VoclosporinThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Voclosporin.Investigational
VogliboseThe therapeutic efficacy of Voglibose can be decreased when used in combination with Tacrolimus.Approved, Investigational
VoriconazoleThe serum concentration of Tacrolimus can be increased when it is combined with Voriconazole.Approved, Investigational
VortioxetineThe metabolism of Tacrolimus can be decreased when combined with Vortioxetine.Approved
VoxilaprevirThe serum concentration of Voxilaprevir can be decreased when it is combined with Tacrolimus.Approved
XimelagatranThe metabolism of Tacrolimus can be decreased when combined with Ximelagatran.Approved, Investigational, Withdrawn
Yellow fever vaccineThe therapeutic efficacy of Yellow fever vaccine can be decreased when used in combination with Tacrolimus.Approved
Z-Val-Ala-Asp fluoromethyl ketoneThe metabolism of Tacrolimus can be decreased when combined with Z-Val-Ala-Asp fluoromethyl ketone.Experimental
ZaltoprofenZaltoprofen may increase the nephrotoxic activities of Tacrolimus.Approved
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Tacrolimus.Approved
ZileutonZileuton may increase the nephrotoxic activities of Tacrolimus.Approved, Investigational, Withdrawn
ZimelidineThe metabolism of Tacrolimus can be decreased when combined with Zimelidine.Withdrawn
ZiprasidoneThe metabolism of Tacrolimus can be decreased when combined with Ziprasidone.Approved
ZofenoprilThe metabolism of Tacrolimus can be decreased when combined with Zofenopril.Experimental
ZomepiracZomepirac may increase the nephrotoxic activities of Tacrolimus.Withdrawn
Zoster vaccineThe therapeutic efficacy of Zoster vaccine can be decreased when used in combination with Tacrolimus.Approved
Food Interactions
  • Food, especially food with a high-fat content, decreases the rate and extent of absorption.
  • The time of the meal affects tacrolimus bioavailability. Take tacrolimus capsules consistently everyday either with or without food.

References

Synthesis Reference

Pan Sup Chang, Hoon Cho, "Water soluble polymer-tacrolimus conjugated compounds and process for preparing the same." U.S. Patent US5922729, issued April, 1997.

US5922729
General References
  1. Kino T, Hatanaka H, Hashimoto M, Nishiyama M, Goto T, Okuhara M, Kohsaka M, Aoki H, Imanaka H: FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics. J Antibiot (Tokyo). 1987 Sep;40(9):1249-55. [PubMed:2445721]
  2. Pritchard DI: Sourcing a chemical succession for cyclosporin from parasites and human pathogens. Drug Discov Today. 2005 May 15;10(10):688-91. [PubMed:15896681]
  3. Liu J, Farmer JD Jr, Lane WS, Friedman J, Weissman I, Schreiber SL: Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. 1991 Aug 23;66(4):807-15. [PubMed:1715244]
  4. Fukatsu S, Fukudo M, Masuda S, Yano I, Katsura T, Ogura Y, Oike F, Takada Y, Inui K: Delayed effect of grapefruit juice on pharmacokinetics and pharmacodynamics of tacrolimus in a living-donor liver transplant recipient. Drug Metab Pharmacokinet. 2006 Apr;21(2):122-5. [PubMed:16702731]
  5. Hanifin JM, Paller AS, Eichenfield L, Clark RA, Korman N, Weinstein G, Caro I, Jaracz E, Rico MJ: Efficacy and safety of tacrolimus ointment treatment for up to 4 years in patients with atopic dermatitis. J Am Acad Dermatol. 2005 Aug;53(2 Suppl 2):S186-94. [PubMed:16021174]
External Links
Human Metabolome Database
HMDB15002
KEGG Drug
D00107
KEGG Compound
C01375
PubChem Compound
445643
PubChem Substance
46506004
ChemSpider
393220
BindingDB
50030448
ChEBI
61049
ChEMBL
CHEMBL269732
Therapeutic Targets Database
DAP000162
PharmGKB
PA451578
HET
FK5
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Tacrolimus
ATC Codes
D11AH01 — TacrolimusL04AD02 — Tacrolimus
AHFS Codes
  • 84:92.00
  • 92:00.00
PDB Entries
FDA label
Download (144 KB)
MSDS
Download (54.9 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedTreatmentTransplantation, Stem Cell1
0TerminatedTreatmentAcute Kidney Injury (AKI)1
0TerminatedTreatmentAllogeneic peripheral haematopoietic stem cell transplant / Neuroepithelial Tumor / Tumors, Solid1
0WithdrawnTreatmentMultiple Myeloma (MM) / Myeloma-Multiple1
1Active Not RecruitingTreatmentAcute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome / Adult Acute Lymphoblastic Leukemia in Remission / Adult Acute Myeloid Leukemia in Remission / CD45-Positive Neoplastic Cells Present / Chronic Myelomonocytic Leukemia / Previously Treated Myelodysplastic Syndromes / Refractory Anemia With Excess Blasts / Refractory Anemia With Ring Sideroblasts / Refractory Cytopenia With Multilineage Dysplasia / Refractory Cytopenia With Multilineage Dysplasia and Ring Sideroblasts1
1CompletedNot AvailableDrug Interactions / Healthy Volunteers / Pharmacokinetics of ASP015K1
1CompletedNot AvailableHealthy Volunteers2
1CompletedNot AvailableHealthy Volunteers / Pharmacokinetics of ASP015K and Tacrolimus1
1CompletedNot AvailableHealthy Volunteers / Pharmacokinetics of Isavuconazole / Pharmacokinetics of Tacrolimus1
1CompletedBasic ScienceChronic Hepatitis C Infection1
1CompletedBasic ScienceDrug Interactions / Hypercholesterolaemia / Immunosuppression / Pharmacokinetics1
1CompletedBasic ScienceHealthy Volunteers1
1CompletedBasic ScienceHealthy Volunteers / Pharmacokinetics / Venous Thromboembolism1
1CompletedPreventionHealthy Volunteers1
1CompletedSupportive CareChronic Myeloproliferative Disorders / Graft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases1
1CompletedTreatmentAllogeneic Stem Cell Transplantation / Malignancies, Hematologic1
1CompletedTreatmentAtopic Dermatitis (AD)1
1CompletedTreatmentBlood And Marrow Transplantation / Leukemias / Malignant Lymphomas / Transplantation Infection / Transplantation, Bone Marrow1
1CompletedTreatmentChronic Graft Versus Host Disease1
1CompletedTreatmentChronic Hepatitis C Virus (HCV) Infection / Immunosuppression / Transplantation, Organ1
1CompletedTreatmentChronic Myeloproliferative Disorders / Graft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Precancerous/Nonmalignant Condition / Small Intestine Cancer1
1CompletedTreatmentChronic Myeloproliferative Disorders / Leukemias / Malignant Lymphomas / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Neoplasms1
1CompletedTreatmentEnd-Stage Renal Disease (ESRD) / Impaired Renal Function / Nephritis, Lupus / Systemic Lupus Erythematosus (SLE)1
1CompletedTreatmentGraft Versus Host Disease (GVHD) / Peripheral Blood Stem Cell Transplantation / Transplantation, Homologous1
1CompletedTreatmentHealthy Volunteers4
1CompletedTreatmentHepatitis C Virus (HCV)1
1CompletedTreatmentLeukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes2
1CompletedTreatmentLeukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases1
1CompletedTreatmentLeukemias / Myelodysplastic Syndrome2
1CompletedTreatmentPsoriasis1
1CompletedTreatmentRenal Replacement Therapies1
1Not Yet RecruitingTreatmentHaemoglobinopathies congenital / Sickle Cell Disorders / Thalassaemic disorders1
1RecruitingDiagnosticBioequivalence1
1RecruitingTreatmentAcute Lymphoblastic Leukemia in Remission / Acute myeloid leukaemia (in remission) / Adult Acute Lymphoblastic Leukemia in Complete Remission / Childhood Acute Lymphoblastic Leukemia in Complete Remission / Previously Treated Myelodysplastic Syndromes / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Recurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Acute Myeloid Leukemia1
1RecruitingTreatmentAcute Lymphocytic Leukemia (ALL) / Agnogenic Myeloid Metaplasia / Chronic Lymphocytic Leukaemia (CLL) / Chronic Myeloid Leukemia (CML) / Leukemia Acute Myeloid Leukemia (AML) / Lymphoma, Hodgkins / Malignancies, Hematologic / Multiple Myeloma (MM) / Myelodysplastic Syndrome / Myeloproliferative Syndromes / Non Hodgkin Lymphoma (NHL)1
1RecruitingTreatmentAgnogenic Myeloid Metaplasia / Leukemias / Malignant Lymphomas / Smith-Magenis Syndrome1
1RecruitingTreatmentAmputations / Genital Diseases, Male / Urologic Injuries1
1RecruitingTreatmentCastration-Resistant Prostate Carcinoma / Leukemia, Plasma Cell / Prostate Carcinoma Metastatic in the Bone / Recurrent Plasma Cell Myeloma / Stage IV Prostate Cancer1
1RecruitingTreatmentChronic Lymphocytic Leukaemia (CLL) / Leukemias1
1RecruitingTreatmentGraft Versus Host Disease (GVHD) / Sickle Cell Disorders1
1RecruitingTreatmentPreviously Treated Myelodysplastic Syndromes / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Recurrent Hematologic Malignancy1
1RecruitingTreatmentRefractory Multiple Myeloma / Stage I Multiple Myeloma / Stage II Multiple Myeloma1
1RecruitingTreatmentSecondary Myelofibrosis1
1RecruitingTreatmentTransplantation, Liver1
1TerminatedTreatmentJuvenile Myelomonocytic Leukemia / Leukemia Acute Myeloid Leukemia (AML) / Myelodysplastic Syndrome1
1TerminatedTreatmentLeukemias / Lymphoma, Hodgkins / Multiple Myeloma (MM) / Non-Hodgkin's Lymphoma (NHL) / Smith-Magenis Syndrome1
1Unknown StatusTreatmentOcular GVHD1
1Unknown StatusTreatmentTransplantation, Organ1
1WithdrawnSupportive CareAcute myeloid leukaemia (in remission) / Primary Myelofibrosis / Primary Myelofibrosis, Prefibrotic Stage / Secondary Acute Myeloid Leukemia / Secondary Myelofibrosis1
1WithdrawnTreatmentCutaneous T-Cell Non-Hodgkin Lymphoma / Recurrent Mycosis Fungoides and Sezary Syndrome / Stage IIB Mycosis Fungoides and Sezary Syndrome / Stage IIIA Mycosis Fungoides and Sezary Syndrome / Stage IIIB Mycosis Fungoides and Sezary Syndrome / Stage IVA Mycosis Fungoides and Sezary Syndrome / Stage IVB Mycosis Fungoides and Sezary Syndrome1
1WithdrawnTreatmentLeukemias / Malignant Lymphomas / Pediatric Disorders / Transplantation, Stem Cell1
1WithdrawnTreatmentScleroderma1
1, 2Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Aggressive Non-Hodgkin Lymphoma / Leukemia Acute Myeloid Leukemia (AML) / Lymphoma, Large B-Cell, Diffuse (DLBCL) / Previously Treated Myelodysplastic Syndromes / Recurrent Chronic Lymphocytic Leukemia / Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Recurrent Indolent Adult Non-Hodgkin Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Plasma Cell Myeloma / Recurrent Small Lymphocytic Lymphoma / Refractory Chronic Lymphocytic Leukemia / Refractory Hodgkin Lymphoma / Refractory Plasma Cell Myeloma / Refractory Small Lymphocytic Lymphoma / Waldenstrom's Macroglobulinemia (WM)1
1, 2Active Not RecruitingTreatmentChronic Myeloproliferative Disorders / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes1
1, 2Active Not RecruitingTreatmentComplete Atypical DiGeorge Anomaly / Complete Atypical DiGeorge Syndrome / Complete DiGeorge Anomaly / Complete DiGeorge Syndrome / DiGeorge Anomaly1
1, 2Active Not RecruitingTreatmentGraft Versus Host Disease (GVHD) / Leukemias / Myelodysplastic Syndromes1
1, 2Active Not RecruitingTreatmentLeukaemia, Acute / Lymphoma, Hodgkins / Multiple Myeloma (MM) / Myelodysplastic Syndrome / Non-Hodgkin's Disease1
1, 2Active Not RecruitingTreatmentMultiple Myeloma (MM)1
1, 2CompletedPreventionMalignancies, Hematologic1
1, 2CompletedSupportive CareChronic Myeloproliferative Disorders / Graft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases1
1, 2CompletedTreatmentCNI Side Effects1
1, 2CompletedTreatmentGraft Versus Host Disease (GVHD) / Malignancies, Hematologic1
1, 2CompletedTreatmentKidney Diseases / Renal Failure / Transplantation, Kidney1
1, 2CompletedTreatmentKidney Diseases / Transplant, Kidney / Transplantation, Kidney / Transplantation, Renal1
1, 2CompletedTreatmentKidney Diseases / Transplantation, Kidney1
1, 2CompletedTreatmentLeukemias1
1, 2CompletedTreatmentLeukemias / Malignant Lymphomas1
1, 2CompletedTreatmentMalignancies, Hematologic3
1, 2Not Yet RecruitingPreventionGraft Versus Host Disease (GVHD) / Lung Cancers1
1, 2Not Yet RecruitingTreatmentAge-Related Macular Degeneration (ARMD)1
1, 2RecruitingBasic ScienceTransplantation, Kidney1
1, 2RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Acute Myelogenous Leukaemia (AML) / Chronic Myeloid Leukemia (CML) / Juvenile Myelomonocytic Leukemia (JMML) / Lymphoma (Hodgkin's and Non-Hodgkin's) / Myelodysplastic Syndromes (MDS)1
1, 2RecruitingTreatmentAdult Living Donor Kidney Transplant Recipients / Living Kidney Donors / Transplant, Kidney1
1, 2RecruitingTreatmentBeta Thalassemia-Major / Sickle Cell Disorders1
1, 2RecruitingTreatmentDiabetes, Diabetes Mellitus Type 11
1, 2RecruitingTreatmentGraft Versus Host Disease (GVHD) / Malignancies, Hematologic / Relapses1
1, 2RecruitingTreatmentHematopoietic Stem Cell Transplantation (HSCT) / Multiple Myeloma (MM)1
1, 2RecruitingTreatmentLeukemia Acute Myeloid Leukemia (AML) / Malignant Neoplasms Stated as Primary Lymphoid Haematopoietic1
1, 2RecruitingTreatmentLeukemias2
1, 2RecruitingTreatmentLeukemias / Malignant Lymphomas1
1, 2RecruitingTreatmentLeukemias / Myeloproliferative Disorders1
1, 2RecruitingTreatmentMalignant Lymphomas1
1, 2RecruitingTreatmentScleroderma, Systemic / Severe Systemic Sclerosis1
1, 2TerminatedTreatmentAcute Lymphoblastic Leukaemias (ALL) / Acute Myelogenous Leukaemia (AML) / Chronic Myelogenous Leukemia (CML) / Hematologic Diseases / Lymphoproliferative Disorders / Multiple Myeloma (MM) / Myelodysplastic and Myeloproliferative Disorders / Plasma Cell Dyscrasia1
1, 2TerminatedTreatmentGraft Versus Host Disease (GVHD)1
1, 2TerminatedTreatmentGraft Versus Host Disease (GVHD) / Leukemias / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases1
1, 2TerminatedTreatmentGraft Versus Host Disease (GVHD) / Lupus Erythematosus1
1, 2TerminatedTreatmentLeukemias / Myeloproliferative Disorders / Plasma Cell Myeloma1
1, 2Unknown StatusTreatmentEnd Stage Renal Disease (ESRD) / Transplant, Kidney1
1, 2Unknown StatusTreatmentEnd-Stage Renal Disease (ESRD) / Renal Failure1
1, 2Unknown StatusTreatmentLeukaemia, Acute / Myelodysplastic Syndrome / Tumors, Solid1
1, 2Unknown StatusTreatmentPeripheral Nerve Injury (PNI)1
1, 2WithdrawnTreatmentMultiple Myeloma (MM) / Refractory Multiple Myeloma1
2Active Not RecruitingOtherHeart Transplantation / Transplantation, Kidney / Transplantation, Liver1
2Active Not RecruitingPreventionAcute Graft Versus Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation / Hematopoietic Stem Cell Transplantation (HSCT)1
2Active Not RecruitingPreventionChronic Lymphocytic Leukaemia (CLL) / Chronic Myelogenous Leukemia (CML) / Follicular Lymphoma (FL) / Leukaemia, Acute / Lymphoma, B-Cell / Lymphoma, Hodgkins / Lymphoma, Large B-Cell, Diffuse (DLBCL) / Myelodysplasia / Small Lymphocytic Lymphoma (SLL)1
2Active Not RecruitingPreventionGraft Versus Host Disease (GVHD)2
2Active Not RecruitingPreventionGraft Versus Host Disease (GVHD) / Neoplasms, Hematologic / Non-Neoplastic Hematologic and Lymphocytic Disorder1
2Active Not RecruitingPreventionHeart Transplantation / Intestine Transplantation / Transplantation, Kidney / Transplantation, Liver / Transplantation, Lung1
2Active Not RecruitingTreatmentAccelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Acute Biphenotypic Leukemia (ABL) / Acute Leukemias of Ambiguous Lineage / Acute myeloid leukaemia (in remission) / Acute Undifferentiated Leukemia (AUL) / Adult Acute Lymphoblastic Leukemia in Remission / Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Childhood Acute Lymphoblastic Leukemia in Remission / Childhood Acute Myeloid Leukemia in Remission / Childhood Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Chronic Myelogenous Leukemia, BCR-ABL1 Positive / RAEB-1 / RAEB-2 / Recurrent Adult Acute Myeloid Leukemia / Recurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Acute Myeloid Leukemia / Refractory Adult Acute Lymphoblastic Leukemia / Refractory Anemia With Excess Blasts / Refractory Childhood Acute Lymphoblastic Leukemia1
2Active Not RecruitingTreatmentAccelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Adult Acute Lymphoblastic Leukemia in Remission / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11 / Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); RUNX1-RUNX1T1 / Adult Acute Myeloid Leukemia With t(9;11)(p22;q23); MLLT3- / Adult Acute Myeloid Leukemia With t(9;11)(p22;q23); MLLT3-MLL / Adult Acute Promyelocytic Leukemia With t(15;17)(q22;q12); PML-RARA / Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative / Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Childhood Acute Lymphoblastic Leukemia in Remission / Childhood Acute Myeloid Leukemia in Remission / Childhood Burkitt Lymphoma / Childhood Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Childhood Diffuse Large Cell Lymphoma / Childhood Immunoblastic Lymphoma / Childhood Myelodysplastic Syndrome / Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable / Previously Treated Myelodysplastic Syndromes / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Hodgkin's Lymphoma / Recurrent Adult Immunoblastic Lymphoma / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Acute Myeloid Leukemia / Recurrent Childhood Anaplastic Large Cell Lymphoma / Recurrent Childhood Burkitt Lymphoma / Recurrent Childhood Hodgkin Lymphoma / Recurrent Childhood Large Cell Lymphoma / Recurrent Childhood Lymphoblastic Lymphoma / Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Small Lymphocytic Lymphoma / Refractory Chronic Lymphocytic Leukemia / Refractory Plasma Cell Myeloma / Secondary Myelodysplastic Syndromes / Stage I Adult Burkitt Lymphoma / Stage I Adult Diffuse Large Cell Lymphoma / Stage I Adult Diffuse Mixed Cell Lymphoma / Stage I Adult Immunoblastic Lymphoma / Stage I Adult Lymphoblastic Lymphoma / Stage I Childhood Anaplastic Large Cell Lymphoma / Stage I Childhood Burkitt Lymphoma / Stage I Childhood Large Cell Lymphoma / Stage I Childhood Lymphoblastic Lymphoma / Stage I Grade 1 Follicular Lymphoma / Stage I Grade 2 Follicular Lymphoma / Stage I Grade 3 Follicular Lymphoma / Stage I Mantle Cell Lymphoma / Stage I Marginal Zone Lymphoma / Stage I Small Lymphocytic Lymphoma / Stage II Adult Contiguous Immunoblastic Lymphoma / Stage II Adult Non-Contiguous Immunoblastic Lymphoma / Stage II Childhood Anaplastic Large Cell Lymphoma / Stage II Childhood Burkitt Lymphoma / Stage II Childhood Lymphoblastic Lymphoma / Stage II Contiguous Adult Burkitt Lymphoma / Stage II Contiguous Adult Diffuse Large Cell Lymphoma / Stage II Contiguous Adult Diffuse Mixed Cell Lymphoma / Stage II Contiguous Adult Diffuse Small Cleaved Cell Lymphoma / Stage II Contiguous Adult Lymphoblastic Lymphoma / Stage II Contiguous Mantle Cell Lymphoma / Stage II Grade 1 Contiguous Follicular Lymphoma / Stage II Grade 1 Non-Contiguous Follicular Lymphoma / Stage II Grade 2 Contiguous Follicular Lymphoma / Stage II Grade 2 Non-Contiguous Follicular Lymphoma / Stage II Grade 3 Contiguous Follicular Lymphoma / Stage II Grade 3 Non-Contiguous Follicular Lymphoma / Stage II Non-Contiguous Adult Burkitt Lymphoma / Stage II Non-Contiguous Adult Diffuse Large Cell Lymphoma / Stage II Non-Contiguous Adult Diffuse Mixed Cell Lymphoma / Stage II Non-Contiguous Adult Diffuse Small Cleaved Cell Lymphoma / Stage II Non-Contiguous Adult Lymphoblastic Lymphoma / Stage II Non-Contiguous Mantle Cell Lymphoma / Stage II Small Lymphocytic Lymphoma / Stage III Adult Burkitt Lymphoma / Stage III Adult Diffuse Large Cell Lymphoma / Stage III Adult Diffuse Mixed Cell Lymphoma / Stage III Adult Diffuse Small Cleaved Cell Lymphoma / Stage III Adult Immunoblastic Lymphoma / Stage III Adult Lymphoblastic Lymphoma / Stage III Childhood Anaplastic Large Cell Lymphoma / Stage III Childhood Burkitt Lymphoma / Stage III Childhood Large Cell Lymphoma / Stage III Childhood Lymphoblastic Lymphoma / Stage III Grade 1 Follicular Lymphoma / Stage III Grade 2 Follicular Lymphoma / Stage III Grade 3 Follicular Lymphoma / Stage III Mantle Cell Lymphoma / Stage III Marginal Zone Lymphoma / Stage III Small Lymphocytic Lymphoma / Stage IV Adult Burkitt Lymphoma / Stage IV Adult Diffuse Large Cell Lymphoma / Stage IV Adult Diffuse Mixed Cell Lymphoma / Stage IV Adult Diffuse Small Cleaved Cell Lymphoma / Stage IV Adult Immunoblastic Lymphoma / Stage IV Adult Lymphoblastic Lymphoma / Stage IV Childhood Anaplastic Large Cell Lymphoma / Stage IV Childhood Burkitt Lymphoma / Stage IV Childhood Large Cell Lymphoma / Stage IV Childhood Lymphoblastic Lymphoma / Stage IV Grade 1 Follicular Lymphoma / Stage IV Grade 2 Follicular Lymphoma / Stage IV Grade 3 Follicular Lymphoma / Stage IV Mantle Cell Lymphoma / Stage IV Marginal Zone Lymphoma / Stage IV Small Lymphocytic Lymphoma / Waldenstrom's Macroglobulinemia (WM)1
2Active Not RecruitingTreatmentAccelerated Phase Chronic Myelogenous Leukemia / Adult Acute Lymphoblastic Leukemia in Remission / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Adult Grade III Lymphomatoid Granulomatosis / Adult Nasal Type Extranodal NK/T-Cell Lymphoma / Anaplastic Large Cell Lymphoma / Angioimmunoblastic T-Cell Lymphoma / Aplastic Anaemia (AA) / Burkitt's Lymphoma / Childhood Acute Lymphoblastic Leukemia in Remission / Childhood Acute Myeloid Leukemia in Remission / Childhood Chronic Myelogenous Leukemia / Childhood Diffuse Large Cell Lymphoma / Childhood Grade III Lymphomatoid Granulomatosis / Childhood Immunoblastic Large Cell Lymphoma / Childhood Myelodysplastic Syndromes / Childhood Nasal Type Extranodal NK/T-cell Lymphoma / Chronic Myelomonocytic Leukemia / Chronic Phase Chronic Myelogenous Leukemia / Congenital Amegakaryocytic Thrombocytopenia / Congenital Hypoplastic Anemia / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Hepatosplenic T-Cell Lymphoma / Juvenile Myelomonocytic Leukemia / Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable / Nodal marginal zone B-cell lymphomas / Paroxysmal Nocturnal Haemoglobinuria (PNH) / Peripheral T-Cell Lymphoma (PTCL) / Polycythemia Vera (PV) / Post-Transplant Lymphoproliferative Disorder / Previously Treated Myelodysplastic Syndromes / Primary Myelofibrosis / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Grade III Lymphomatoid Granulomatosis / Recurrent Adult Hodgkin's Lymphoma / Recurrent Adult Immunoblastic Large Cell Lymphoma / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Adult T-Cell Leukemia/Lymphoma / Recurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Acute Myeloid Leukemia / Recurrent Childhood Anaplastic Large Cell Lymphoma / Recurrent Childhood Grade III Lymphomatoid Granulomatosis / Recurrent Childhood Large Cell Lymphoma / Recurrent Childhood Lymphoblastic Lymphoma / Recurrent Childhood Small Noncleaved Cell Lymphoma / Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Mycosis Fungoides/Sezary Syndrome / Recurrent Small Lymphocytic Lymphoma / Recurrent/Refractory Childhood Hodgkin Lymphoma / Refractory Chronic Lymphocytic Leukemia / Refractory Hairy Cell Leukemia / Refractory Multiple Myeloma / Secondary Acute Myeloid Leukemia / Secondary Myelodysplastic Syndromes / Secondary Myelofibrosis / Severe Combined Immunodeficiency / Severe Congenital Neutropenia / Shwachman-Diamond Syndrome / Splenic Marginal Zone Lymphoma / T-Cell Large Granular Lymphocyte Leukemia / Waldenstrom's Macroglobulinemia (WM) / Wiskott-Aldrich Syndrome (WAS)1
2Active Not RecruitingTreatmentAccelerated Phase Chronic Myelogenous Leukemia / Adult Acute Lymphoblastic Leukemia in Remission / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Adult Nasal Type Extranodal NK/T-Cell Lymphoma / Anaplastic Large Cell Lymphoma / Angioimmunoblastic T-Cell Lymphoma / Blastic Phase Chronic Myelogenous Leukemia / Childhood Acute Lymphoblastic Leukemia in Remission / Childhood Acute Myeloid Leukemia in Remission / Childhood Burkitt Lymphoma / Childhood Chronic Myelogenous Leukemia / Childhood Diffuse Large Cell Lymphoma / Childhood Immunoblastic Large Cell Lymphoma / Childhood Myelodysplastic Syndromes / Childhood Nasal Type Extranodal NK/T-cell Lymphoma / Chronic Phase Chronic Myelogenous Leukemia / Contiguous Stage II Adult Burkitt Lymphoma / Contiguous Stage II Adult Diffuse Large Cell Lymphoma / Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma / Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma / Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma / Contiguous Stage II Adult Lymphoblastic Lymphoma / Contiguous Stage II Grade 1 Follicular Lymphoma / Contiguous Stage II Grade 2 Follicular Lymphoma / Contiguous Stage II Grade 3 Follicular Lymphoma / Contiguous Stage II Mantle Cell Lymphoma / Contiguous Stage II Marginal Zone Lymphoma / Contiguous Stage II Small Lymphocytic Lymphoma / Cutaneous B-Cell Non-Hodgkin Lymphoma / De Novo Myelodysplastic Syndromes / Essential Thrombocythemia (ET) / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Hepatosplenic T-Cell Lymphoma / Intraocular Lymphoma / Leukemia, Prolymphocytic / Nodal marginal zone B-cell lymphomas / Noncontiguous Stage II Adult Burkitt Lymphoma / Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma / Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma / Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma / Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma / Noncontiguous Stage II Adult Lymphoblastic Lymphoma / Noncontiguous Stage II Grade 1 Follicular Lymphoma / Noncontiguous Stage II Grade 2 Follicular Lymphoma / Noncontiguous Stage II Grade 3 Follicular Lymphoma / Noncontiguous Stage II Mantle Cell Lymphoma / Noncontiguous Stage II Marginal Zone Lymphoma / Noncontiguous Stage II Small Lymphocytic Lymphoma / Noncutaneous Extranodal Lymphoma / Peripheral T-Cell Lymphoma (PTCL) / Polycythemia Vera (PV) / Post-Transplant Lymphoproliferative Disorder / Previously Treated Myelodysplastic Syndromes / Primary Myelofibrosis / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Grade III Lymphomatoid Granulomatosis / Recurrent Adult Hodgkin's Lymphoma / Recurrent Adult Immunoblastic Large Cell Lymphoma / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Adult T-Cell Leukemia/Lymphoma / Recurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Acute Myeloid Leukemia / Recurrent Childhood Anaplastic Large Cell Lymphoma / Recurrent Childhood Grade III Lymphomatoid Granulomatosis / Recurrent Childhood Large Cell Lymphoma / Recurrent Childhood Lymphoblastic Lymphoma / Recurrent Childhood Small Noncleaved Cell Lymphoma / Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Mycosis Fungoides/Sezary Syndrome / Recurrent Small Lymphocytic Lymphoma / Recurrent/Refractory Childhood Hodgkin Lymphoma / Refractory Chronic Lymphocytic Leukemia / Refractory Hairy Cell Leukemia / Refractory Multiple Myeloma / Relapsing Chronic Myelogenous Leukemia / Small Intestine Lymphoma / Splenic Marginal Zone Lymphoma / Stage I Adult Burkitt Lymphoma / Stage I Adult Diffuse Large Cell Lymphoma / Stage I Adult Diffuse Mixed Cell Lymphoma / Stage I Adult Diffuse Small Cleaved Cell Lymphoma / Stage I Adult Immunoblastic Large Cell Lymphoma / Stage I Adult Lymphoblastic Lymphoma / Stage I Adult T-Cell Leukemia/Lymphoma / Stage I Childhood Anaplastic Large Cell Lymphoma / Stage I Childhood Large Cell Lymphoma / Stage I Childhood Lymphoblastic Lymphoma / Stage I Childhood Small Noncleaved Cell Lymphoma / Stage I Chronic Lymphocytic Leukemia / Stage I Cutaneous T-cell Non-Hodgkin Lymphoma / Stage I Grade 1 Follicular Lymphoma / Stage I Grade 2 Follicular Lymphoma / Stage I Grade 3 Follicular Lymphoma / Stage I Mantle Cell Lymphoma / Stage I Marginal Zone Lymphoma / Stage I Multiple Myeloma / Stage I Small Lymphocytic Lymphoma / Stage IA Mycosis Fungoides/Sezary Syndrome / Stage IB Mycosis Fungoides/Sezary Syndrome / Stage II Adult T-Cell Leukemia/Lymphoma / Stage II Childhood Anaplastic Large Cell Lymphoma / Stage II Childhood Large Cell Lymphoma / Stage II Childhood Lymphoblastic Lymphoma / Stage II Childhood Small Noncleaved Cell Lymphoma / Stage II Chronic Lymphocytic Leukemia / Stage II Cutaneous T-cell Non-Hodgkin Lymphoma / Stage II Multiple Myeloma / Stage IIA Mycosis Fungoides/Sezary Syndrome / Stage IIB Mycosis Fungoides/Sezary Syndrome / Stage III Adult Burkitt Lymphoma / Stage III Adult Diffuse Large Cell Lymphoma / Stage III Adult Diffuse Mixed Cell Lymphoma / Stage III Adult Diffuse Small Cleaved Cell Lymphoma / Stage III Adult Immunoblastic Large Cell Lymphoma / Stage III Adult Lymphoblastic Lymphoma / Stage III Adult T-Cell Leukemia/Lymphoma / Stage III Childhood Anaplastic Large Cell Lymphoma / Stage III Childhood Large Cell Lymphoma / Stage III Childhood Lymphoblastic Lymphoma / Stage III Childhood Small Noncleaved Cell Lymphoma / Stage III Chronic Lymphocytic Leukemia / Stage III Cutaneous T-Cell Non-Hodgkin Lymphoma / Stage III Grade 1 Follicular Lymphoma / Stage III Grade 2 Follicular Lymphoma / Stage III Grade 3 Follicular Lymphoma / Stage III Mantle Cell Lymphoma / Stage III Marginal Zone Lymphoma / Stage III Multiple Myeloma / Stage III Small Lymphocytic Lymphoma / Stage IIIA Mycosis Fungoides/Sezary Syndrome / Stage IIIB Mycosis Fungoides/Sezary Syndrome / Stage IV Adult Burkitt Lymphoma / Stage IV Adult Diffuse Large Cell Lymphoma / Stage IV Adult Diffuse Mixed Cell Lymphoma / Stage IV Adult Diffuse Small Cleaved Cell Lymphoma / Stage IV Adult Immunoblastic Large Cell Lymphoma / Stage IV Adult Lymphoblastic Lymphoma / Stage IV Adult T-Cell Leukemia/Lymphoma / Stage IV Childhood Anaplastic Large Cell Lymphoma / Stage IV Childhood Large Cell Lymphoma / Stage IV Childhood Lymphoblastic Lymphoma / Stage IV Childhood Small Noncleaved Cell Lymphoma / Stage IV Chronic Lymphocytic Leukemia / Stage IV Cutaneous T-Cell Non-Hodgkin Lymphoma / Stage IV Grade 1 Follicular Lymphoma / Stage IV Grade 2 Follicular Lymphoma / Stage IV Grade 3 Follicular Lymphoma / Stage IV Mantle Cell Lymphoma / Stage IV Marginal Zone Lymphoma / Stage IV Small Lymphocytic Lymphoma / Stage IVA Mycosis Fungoides/Sezary Syndrome / Stage IVB Mycosis Fungoides/Sezary Syndrome / Testicular Lymphoma / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Adult Acute Myeloid Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia / Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies / Waldenstrom's Macroglobulinemia (WM)1
2Active Not RecruitingTreatmentAccelerated Phase Chronic Myelogenous Leukemia / Adult Acute Lymphoblastic Leukemia in Remission / Adult Acute Myeloid Leukemia in Remission / Adult Nasal Type Extranodal NK/T-Cell Lymphoma / Blastic Phase Chronic Myelogenous Leukemia / Contiguous Stage II Adult Burkitt Lymphoma / Contiguous Stage II Adult Diffuse Large Cell Lymphoma / Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma / Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma / Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma / Contiguous Stage II Adult Lymphoblastic Lymphoma / Contiguous Stage II Grade 1 Follicular Lymphoma / Contiguous Stage II Grade 2 Follicular Lymphoma / Contiguous Stage II Grade 3 Follicular Lymphoma / Contiguous Stage II Mantle Cell Lymphoma / Contiguous Stage II Marginal Zone Lymphoma / Contiguous Stage II Small Lymphocytic Lymphoma / De Novo Myelodysplastic Syndromes / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Graft Versus Host Disease (GVHD) / Nodal marginal zone B-cell lymphomas / Noncontiguous Stage II Adult Burkitt Lymphoma / Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma / Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma / Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma / Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma / Noncontiguous Stage II Adult Lymphoblastic Lymphoma / Noncontiguous Stage II Grade 1 Follicular Lymphoma / Noncontiguous Stage II Grade 2 Follicular Lymphoma / Noncontiguous Stage II Grade 3 Follicular Lymphoma / Noncontiguous Stage II Mantle Cell Lymphoma / Noncontiguous Stage II Marginal Zone Lymphoma / Noncontiguous Stage II Small Lymphocytic Lymphoma / Previously Treated Myelodysplastic Syndromes / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Grade III Lymphomatoid Granulomatosis / Recurrent Adult Immunoblastic Large Cell Lymphoma / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Adult T-Cell Leukemia/Lymphoma / Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Mycosis Fungoides/Sezary Syndrome / Recurrent Small Lymphocytic Lymphoma / Refractory Chronic Lymphocytic Leukemia / Relapsing Chronic Myelogenous Leukemia / Secondary Myelodysplastic Syndromes / Splenic Marginal Zone Lymphoma / Stage I Adult Burkitt Lymphoma / Stage I Adult Diffuse Large Cell Lymphoma / Stage I Adult Diffuse Mixed Cell Lymphoma / Stage I Adult Diffuse Small Cleaved Cell Lymphoma / Stage I Adult Immunoblastic Large Cell Lymphoma / Stage I Adult Lymphoblastic Lymphoma / Stage I Adult T-Cell Leukemia/Lymphoma / Stage I Chronic Lymphocytic Leukemia / Stage I Cutaneous T-cell Non-Hodgkin Lymphoma / Stage I Grade 1 Follicular Lymphoma / Stage I Grade 2 Follicular Lymphoma / Stage I Grade 3 Follicular Lymphoma / Stage I Mantle Cell Lymphoma / Stage I Marginal Zone Lymphoma / Stage I Mycosis Fungoides/Sezary Syndrome / Stage I Small Lymphocytic Lymphoma / Stage II Adult T-Cell Leukemia/Lymphoma / Stage II Chronic Lymphocytic Leukemia / Stage II Cutaneous T-cell Non-Hodgkin Lymphoma / Stage II Mycosis Fungoides/Sezary Syndrome / Stage III Adult Burkitt Lymphoma / Stage III Adult Diffuse Large Cell Lymphoma / Stage III Adult Diffuse Mixed Cell Lymphoma / Stage III Adult Diffuse Small Cleaved Cell Lymphoma / Stage III Adult Immunoblastic Large Cell Lymphoma / Stage III Adult Lymphoblastic Lymphoma / Stage III Adult T-Cell Leukemia/Lymphoma / Stage III Chronic Lymphocytic Leukemia / Stage III Cutaneous T-Cell Non-Hodgkin Lymphoma / Stage III Grade 1 Follicular Lymphoma / Stage III Grade 2 Follicular Lymphoma / Stage III Grade 3 Follicular Lymphoma / Stage III Mantle Cell Lymphoma / Stage III Marginal Zone Lymphoma / Stage III Mycosis Fungoides/Sezary Syndrome / Stage III Small Lymphocytic Lymphoma / Stage IV Adult Burkitt Lymphoma / Stage IV Adult Diffuse Large Cell Lymphoma / Stage IV Adult Diffuse Mixed Cell Lymphoma / Stage IV Adult Diffuse Small Cleaved Cell Lymphoma / Stage IV Adult Immunoblastic Large Cell Lymphoma / Stage IV Adult Lymphoblastic Lymphoma / Stage IV Adult T-Cell Leukemia/Lymphoma / Stage IV Chronic Lymphocytic Leukemia / Stage IV Cutaneous T-Cell Non-Hodgkin Lymphoma / Stage IV Grade 1 Follicular Lymphoma / Stage IV Grade 2 Follicular Lymphoma / Stage IV Grade 3 Follicular Lymphoma / Stage IV Mantle Cell Lymphoma / Stage IV Marginal Zone Lymphoma / Stage IV Mycosis Fungoides/Sezary Syndrome / Stage IV Small Lymphocytic Lymphoma / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Adult Acute Myeloid Leukemia / Waldenstrom's Macroglobulinemia (WM)1
2Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 / Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1 / Untreated Adult Acute Lymphoblastic Leukemia1
2Active Not RecruitingTreatmentAcute Lymphocytic Leukemia (ALL) / Acute Myelogenous Leukaemia (AML) / Myelodysplastic Syndrome RAEB 1 / Myelodysplastic Syndrome RAEB 21
2Active Not RecruitingTreatmentAcute Lymphocytic Leukemia (ALL) / Chronic Lymphocytic Leukaemia (CLL) / Chronic Myeloid Leukemia (CML) / Leukemia Acute Myeloid Leukemia (AML) / Leukemias / Lymphoma, Hodgkins / Multiple Myeloma (MM) / Myelodysplastic Syndrome / Myeloproliferative Disorders / Non-Hodgkin's Lymphoma (NHL)1
2Active Not RecruitingTreatmentAcute Lymphocytic Leukemia (ALL) / Chronic Lymphocytic Leukaemia (CLL) / Immune System Diseases / Leukemia Acute Myeloid Leukemia (AML) / Malignant Lymphomas / Myelodysplastic Syndromes1
2Active Not RecruitingTreatmentAcute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome / Adult Acute Myeloid Leukemia in Remission1
2Active Not RecruitingTreatmentAcute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / De Novo Myelodysplastic Syndromes / Previously Treated Myelodysplastic Syndromes / Recurrent Adult Acute Myeloid Leukemia / Secondary Acute Myeloid Leukemia1
2Active Not RecruitingTreatmentAdult Acute Lymphoblastic Leukemia in Remission / Adult B Acute Lymphoblastic Leukemia / Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1 / Adult L1 Acute Lymphoblastic Leukemia / Adult L2 Acute Lymphoblastic Leukemia / Adult T Acute Lymphoblastic Leukemia / Recurrent Adult Acute Lymphoblastic Leukemia / Untreated Adult Acute Lymphoblastic Leukemia1
2Active Not RecruitingTreatmentAdult Acute Megakaryoblastic Leukemia / Adult Acute Monoblastic Leukemia / Adult Acute Monocytic Leukemia / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11 / Adult Acute Myeloid Leukemia With Maturation / Adult Acute Myeloid Leukemia With Minimal Differentiation / Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11 / Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); RUNX1-RUNX1T1 / Adult Acute Myeloid Leukemia With t(8;21); (q22; q22.1); RUNX1-RUNX1T1 / Adult Acute Myeloid Leukemia With t(9;11)(p22.3;q23.3); MLLT3-KMT2A / Adult Acute Myeloid Leukemia With t(9;11)(p22;q23); MLLT3-MLL / Adult Acute Myeloid Leukemia Without Maturation / Adult Acute Myelomonocytic Leukemia / Adult Erythroleukemia / Adult Pure Erythroid Leukemia / Alkylating Agent-Related Acute Myeloid Leukemia / De Novo Myelodysplastic Syndrome / Myelodysplastic Syndrome With Excess Blasts / Previously Treated Myelodysplastic Syndromes / Recurrent Adult Acute Myeloid Leukemia / Refractory Anemia With Excess Blasts / Secondary Myelodysplastic Syndromes / Untreated Adult Acute Myeloid Leukemia1
2Active Not RecruitingTreatmentChronic Lymphocytic Leukaemia (CLL) / Chronic Myelogenous Leukemia (CML) / Leukemia Acute Myeloid Leukemia (AML) / Leukemias / Lymphoma, Hodgkins / Multiple Myeloma (MM) / Myelodysplastic Syndrome / Non-Hodgkin's Lymphoma (NHL)1
2Active Not RecruitingTreatmentChronic Lymphocytic Leukaemia (CLL) / Lymphoma, Hodgkins / Lymphoma, Large B-Cell, Diffuse (DLBCL) / Lymphoma, Low-Grade / Lymphoma, Mantle-Cell / Small Lymphocytic Lymphoma (SLL) / T-Cell Lymphomas1
2Active Not RecruitingTreatmentChronic Myeloproliferative Disorders / Graft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases / Precancerous/Nonmalignant Condition1
2Active Not RecruitingTreatmentChronic Myeloproliferative Disorders / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes2
2Active Not RecruitingTreatmentChronic Myeloproliferative Disorders / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases1
2Active Not RecruitingTreatmentGraft Versus Host Disease (GVHD)2
2Active Not RecruitingTreatmentGraft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas1
2Active Not RecruitingTreatmentGraft Versus Host Disease (GVHD) / Leukemias / Myelodysplastic Syndromes1
2Active Not RecruitingTreatmentJuvenile Myelomonocytic Leukemia1
2Active Not RecruitingTreatmentLeukemias1
2Active Not RecruitingTreatmentLeukemias / Malignant Lymphomas2
2Active Not RecruitingTreatmentLeukemias / Malignant Lymphomas / Transplantation, Stem Cell1
2Active Not RecruitingTreatmentTransplantation, Kidney1
2CompletedNot AvailableAtopic Dermatitis (AD)1
2CompletedPreventionAcute Graft Versus Host Disease1
2CompletedPreventionAcute Lymphoblastic Leukaemias (ALL) / Acute Myelogenous Leukaemia (AML) / Chronic Myelogenous Leukemia (CML) / Graft Versus Host Disease (GVHD) / Hodgkins Disease (HD) / Myelodysplastic Syndromes / Non-Hodgkin's Lymphoma (NHL)1
2CompletedPreventionAcute Lymphoblastic Leukaemias (ALL) / Hodgkins Disease (HD) / Malignancies, Hematologic / Myelodysplastic Syndrome / Myelogenous Leukemia / Non-Hodgkin's Lymphoma (NHL)1
2CompletedPreventionChronic Hepatitis C Infection / Transplantation, Liver1
2CompletedPreventionChronic Lung Diseases1
2CompletedPreventionDe Novo Kidney Transplantation1
2CompletedPreventionDiabetes, Diabetes Mellitus Type 11
2CompletedPreventionHeart Transplantation / Pancreas (Including SPK) Transplantation / Transplantation, Lung1
2CompletedPreventionImmunosuppression / Kidney Failure,Chronic / Transplantation, Kidney1
2CompletedPreventionLiver Dysfunction / Rejection, Transplant / Transplantation, Liver1
2CompletedPreventionTransplantation, Kidney3
2CompletedPreventionTransplantation, Liver2
2CompletedSupportive CareAccelerated Phase Chronic Myelogenous Leukemia / Adult Acute Lymphoblastic Leukemia in Remission / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Atypical Chronic Myeloid Leukemia / Blastic Phase Chronic Myelogenous Leukemia / Childhood Acute Lymphoblastic Leukemia in Remission / Childhood Acute Myeloid Leukemia in Remission / Childhood Chronic Myelogenous Leukemia / Childhood Myelodysplastic Syndromes / Chronic Eosinophilic Leukemia (CEL) / Chronic Myelomonocytic Leukemia / Chronic Neutrophilic Leukemia / Chronic Phase Chronic Myelogenous Leukemia / Contiguous Stage II Adult Burkitt Lymphoma / Contiguous Stage II Adult Diffuse Large Cell Lymphoma / Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma / Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma / Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma / Contiguous Stage II Adult Lymphoblastic Lymphoma / Contiguous Stage II Grade 1 Follicular Lymphoma / Contiguous Stage II Grade 2 Follicular Lymphoma / Contiguous Stage II Grade 3 Follicular Lymphoma / Contiguous Stage II Mantle Cell Lymphoma / Contiguous Stage II Marginal Zone Lymphoma / Contiguous Stage II Small Lymphocytic Lymphoma / De Novo Myelodysplastic Syndromes / Essential Thrombocythemia (ET) / Extramedullary Plasmacytoma / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Graft Versus Host Disease (GVHD) / Hematopoietic/Lymphoid Cancer / Isolated Plasmacytoma of Bone / Juvenile Myelomonocytic Leukemia / Meningeal Chronic Myelogenous Leukemia / Myelodysplastic/Myeloproliferative Disease, Unclassifiable / Nodal marginal zone B-cell lymphomas / Noncontiguous Stage II Adult Burkitt Lymphoma / Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma / Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma / Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma / Noncontiguous Stage II Adult Lymphoblastic Lymphoma / Noncontiguous Stage II Grade 1 Follicular Lymphoma / Noncontiguous Stage II Grade 2 Follicular Lymphoma / Noncontiguous Stage II Grade 3 Follicular Lymphoma / Noncontiguous Stage II Mantle Cell Lymphoma / Noncontiguous Stage II Marginal Zone Lymphoma / Noncontiguous Stage II Small Lymphocytic Lymphoma / Previously Treated Myelodysplastic Syndromes / Primary Myelofibrosis / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Grade III Lymphomatoid Granulomatosis / Recurrent Adult Hodgkin's Lymphoma / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Adult T-Cell Leukemia/Lymphoma / Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Mycosis Fungoides/Sezary Syndrome / Recurrent Small Lymphocytic Lymphoma / Recurrent/Refractory Childhood Hodgkin Lymphoma / Refractory Chronic Lymphocytic Leukemia / Refractory Hairy Cell Leukemia / Relapsing Chronic Myelogenous Leukemia / Secondary Myelodysplastic Syndromes / Stage I Adult Burkitt Lymphoma / Stage I Adult Diffuse Large Cell Lymphoma / Stage I Adult Diffuse Mixed Cell Lymphoma / Stage I Adult Diffuse Small Cleaved Cell Lymphoma / Stage I Adult Hodgkin Lymphoma / Stage I Adult Immunoblastic Large Cell Lymphoma / Stage I Adult Lymphoblastic Lymphoma / Stage I Adult T-Cell Leukemia/Lymphoma / Stage I Childhood Hodgkin Lymphoma / Stage I Chronic Lymphocytic Leukemia / Stage I Cutaneous T-cell Non-Hodgkin Lymphoma / Stage I Grade 1 Follicular Lymphoma / Stage I Grade 2 Follicular Lymphoma / Stage I Grade 3 Follicular Lymphoma / Stage I Mantle Cell Lymphoma / Stage I Marginal Zone Lymphoma / Stage I Multiple Myeloma / Stage I Mycosis Fungoides/Sezary Syndrome / Stage I Small Lymphocytic Lymphoma / Stage II Adult Hodgkin Lymphoma / Stage II Adult T-Cell Leukemia/Lymphoma / Stage II Chronic Lymphocytic Leukemia / Stage II Cutaneous T-cell Non-Hodgkin Lymphoma / Stage II Multiple Myeloma / Stage II Mycosis Fungoides/Sezary Syndrome / Stage III Adult Burkitt Lymphoma / Stage III Adult Diffuse Large Cell Lymphoma / Stage III Adult Diffuse Mixed Cell Lymphoma / Stage III Adult Diffuse Small Cleaved Cell Lymphoma / Stage III Adult Hodgkin Lymphoma / Stage III Adult Immunoblastic Large Cell Lymphoma / Stage III Adult Lymphoblastic Lymphoma / Stage III Adult T-Cell Leukemia/Lymphoma / Stage III Chronic Lymphocytic Leukemia / Stage III Cutaneous T-Cell Non-Hodgkin Lymphoma / Stage III Grade 1 Follicular Lymphoma / Stage III Grade 2 Follicular Lymphoma / Stage III Grade 3 Follicular Lymphoma / Stage III Mantle Cell Lymphoma / Stage III Marginal Zone Lymphoma / Stage III Multiple Myeloma / Stage III Mycosis Fungoides/Sezary Syndrome / Stage III Small Lymphocytic Lymphoma / Stage IV Adult Burkitt Lymphoma / Stage IV Adult Diffuse Large Cell Lymphoma / Stage IV Adult Diffuse Mixed Cell Lymphoma / Stage IV Adult Diffuse Small Cleaved Cell Lymphoma / Stage IV Adult Hodgkin Lymphoma / Stage IV Adult Immunoblastic Large Cell Lymphoma / Stage IV Adult Lymphoblastic Lymphoma / Stage IV Adult T-Cell Leukemia/Lymphoma / Stage IV Chronic Lymphocytic Leukemia / Stage IV Cutaneous T-Cell Non-Hodgkin Lymphoma / Stage IV Grade 1 Follicular Lymphoma / Stage IV Grade 2 Follicular Lymphoma / Stage IV Grade 3 Follicular Lymphoma / Stage IV Marginal Zone Lymphoma / Stage IV Mycosis Fungoides/Sezary Syndrome / Stage IV Small Lymphocytic Lymphoma1
2CompletedSupportive CareAccelerated Phase Chronic Myelogenous Leukemia / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Adult Grade III Lymphomatoid Granulomatosis / B-Cell Chronic Lymphocytic Leukemia / Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Chronic Myelomonocytic Leukemia / Chronic Phase Chronic Myelogenous Leukemia / Contiguous Stage II Adult Burkitt Lymphoma / Contiguous Stage II Adult Diffuse Large Cell Lymphoma / Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma / Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma / Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma / Contiguous Stage II Adult Lymphoblastic Lymphoma / Contiguous Stage II Grade 1 Follicular Lymphoma / Contiguous Stage II Grade 2 Follicular Lymphoma / Contiguous Stage II Grade 3 Follicular Lymphoma / Contiguous Stage II Mantle Cell Lymphoma / Contiguous Stage II Marginal Zone Lymphoma / Contiguous Stage II Small Lymphocytic Lymphoma / Cutaneous B-Cell Non-Hodgkin Lymphoma / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Graft Versus Host Disease (GVHD) / Intraocular Lymphoma / Myelodysplastic Syndrome With Isolated Del(5q) / Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable / Nodal marginal zone B-cell lymphomas / Noncontiguous Stage II Adult Burkitt Lymphoma / Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma / Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma / Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma / Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma / Noncontiguous Stage II Adult Lymphoblastic Lymphoma / Noncontiguous Stage II Grade 1 Follicular Lymphoma / Noncontiguous Stage II Grade 2 Follicular Lymphoma / Noncontiguous Stage II Grade 3 Follicular Lymphoma / Noncontiguous Stage II Mantle Cell Lymphoma / Noncontiguous Stage II Marginal Zone Lymphoma / Noncontiguous Stage II Small Lymphocytic Lymphoma / Post-Transplant Lymphoproliferative Disorder / Primary Central Nervous System Hodgkin Lymphoma / Primary Central Nervous System Non-Hodgkin Lymphoma / Recurrent Adult Acute Myeloid Leukemia / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Grade III Lymphomatoid Granulomatosis / Recurrent Adult Hodgkin's Lymphoma / Recurrent Adult Immunoblastic Large Cell Lymphoma / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Small Lymphocytic Lymphoma / Refractory Anemia / Refractory Anemia With Excess Blasts / Refractory Anemia With Ringed Sideroblasts / Refractory Chronic Lymphocytic Leukemia / Refractory Cytopenia With Multilineage Dysplasia / Refractory Hairy Cell Leukemia / Relapsing Chronic Myelogenous Leukemia / Secondary Central Nervous System Hodgkin Lymphoma / Secondary Central Nervous System Non-Hodgkin Lymphoma / Small Intestine Lymphoma / Splenic Marginal Zone Lymphoma / Stage I Adult Burkitt Lymphoma / Stage I Adult Diffuse Large Cell Lymphoma / Stage I Adult Diffuse Mixed Cell Lymphoma / Stage I Adult Diffuse Small Cleaved Cell Lymphoma / Stage I Adult Hodgkin Lymphoma / Stage I Adult Immunoblastic Large Cell Lymphoma / Stage I Adult Lymphoblastic Lymphoma / Stage I Chronic Lymphocytic Leukemia / Stage I Grade 1 Follicular Lymphoma / Stage I Grade 2 Follicular Lymphoma / Stage I Grade 3 Follicular Lymphoma / Stage I Mantle Cell Lymphoma / Stage I Marginal Zone Lymphoma / Stage I Small Lymphocytic Lymphoma / Stage II Adult Hodgkin Lymphoma / Stage II Chronic Lymphocytic Leukemia / Stage III Adult Burkitt Lymphoma / Stage III Adult Diffuse Large Cell Lymphoma / Stage III Adult Diffuse Mixed Cell Lymphoma / Stage III Adult Diffuse Small Cleaved Cell Lymphoma / Stage III Adult Hodgkin Lymphoma / Stage III Adult Immunoblastic Large Cell Lymphoma / Stage III Adult Lymphoblastic Lymphoma / Stage III Chronic Lymphocytic Leukemia / Stage III Grade 1 Follicular Lymphoma / Stage III Grade 2 Follicular Lymphoma / Stage III Grade 3 Follicular Lymphoma / Stage III Mantle Cell Lymphoma / Stage III Marginal Zone Lymphoma / Stage IV Adult Burkitt Lymphoma / Stage IV Adult Diffuse Large Cell Lymphoma / Stage IV Adult Diffuse Mixed Cell Lymphoma / Stage IV Adult Diffuse Small Cleaved Cell Lymphoma / Stage IV Adult Hodgkin Lymphoma / Stage IV Adult Immunoblastic Large Cell Lymphoma / Stage IV Adult Lymphoblastic Lymphoma / Stage IV Chronic Lymphocytic Leukemia / Stage IV Grade 1 Follicular Lymphoma / Stage IV Grade 2 Follicular Lymphoma / Stage IV Grade 3 Follicular Lymphoma / Stage IV Mantle Cell Lymphoma / Stage IV Marginal Zone Lymphoma / Stage IV Small Lymphocytic Lymphoma / Testicular Lymphoma / Waldenstrom's Macroglobulinemia (WM)1
2CompletedSupportive CareCancer, Breast / Cancer, Ovarian / Chronic Myeloproliferative Disorders / Gestational Trophoblastic Disease / Graft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases / Neuroblastomas / Testicular germ cell tumour1
2CompletedSupportive CareChronic Myeloproliferative Disorders / Graft Versus Host Disease (GVHD) / Infection NOS / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Neoplasms / Precancerous Conditions / Secondary Myelofibrosis / Small Intestine Cancer1
2CompletedSupportive CareChronic Myeloproliferative Disorders / Graft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases1
2CompletedTreatmentAccelerated Phase Chronic Myelogenous Leukemia / Adult Acute Lymphoblastic Leukemia in Remission / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Adult Nasal Type Extranodal NK/T-Cell Lymphoma / Anaplastic Large Cell Lymphoma / Angioimmunoblastic T-Cell Lymphoma / Childhood Acute Lymphoblastic Leukemia in Remission / Childhood Acute Myeloid Leukemia in Remission / Childhood Burkitt Lymphoma / Childhood Chronic Myelogenous Leukemia / Childhood Myelodysplastic Syndromes / Childhood Nasal Type Extranodal NK/T-cell Lymphoma / Cutaneous B-Cell Non-Hodgkin Lymphoma / De Novo Myelodysplastic Syndromes / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Hematopoietic/Lymphoid Cancer / Hepatosplenic T-Cell Lymphoma / Intraocular Lymphoma / Nodal marginal zone B-cell lymphomas / Peripheral T-Cell Lymphoma (PTCL) / Post-Transplant Lymphoproliferative Disorder / Previously Treated Myelodysplastic Syndromes / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Grade III Lymphomatoid Granulomatosis / Recurrent Adult Hodgkin's Lymphoma / Recurrent Adult Immunoblastic Large Cell Lymphoma / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Adult T-Cell Leukemia/Lymphoma / Recurrent Childhood Anaplastic Large Cell Lymphoma / Recurrent Childhood Grade III Lymphomatoid Granulomatosis / Recurrent Childhood Large Cell Lymphoma / Recurrent Childhood Lymphoblastic Lymphoma / Recurrent Childhood Small Noncleaved Cell Lymphoma / Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Mycosis Fungoides/Sezary Syndrome / Recurrent Small Lymphocytic Lymphoma / Recurrent/Refractory Childhood Hodgkin Lymphoma / Refractory Chronic Lymphocytic Leukemia / Refractory Multiple Myeloma / Relapsing Chronic Myelogenous Leukemia / Secondary Myelodysplastic Syndromes / Small Intestine Lymphoma / Splenic Marginal Zone Lymphoma / Stage II Multiple Myeloma / Stage III Adult Burkitt Lymphoma / Stage III Adult Diffuse Large Cell Lymphoma / Stage III Adult Diffuse Mixed Cell Lymphoma / Stage III Adult Diffuse Small Cleaved Cell Lymphoma / Stage III Adult Hodgkin Lymphoma / Stage III Adult Immunoblastic Large Cell Lymphoma / Stage III Adult Lymphoblastic Lymphoma / Stage III Adult T-Cell Leukemia/Lymphoma / Stage III Childhood Hodgkin Lymphoma / Stage III Chronic Lymphocytic Leukemia / Stage III Cutaneous T-Cell Non-Hodgkin Lymphoma / Stage III Grade 1 Follicular Lymphoma / Stage III Grade 2 Follicular Lymphoma / Stage III Grade 3 Follicular Lymphoma / Stage III Mantle Cell Lymphoma / Stage III Marginal Zone Lymphoma / Stage III Multiple Myeloma / Stage III Mycosis Fungoides/Sezary Syndrome / Stage III Small Lymphocytic Lymphoma / Stage IV Adult Burkitt Lymphoma / Stage IV Adult Diffuse Large Cell Lymphoma / Stage IV Adult Diffuse Mixed Cell Lymphoma / Stage IV Adult Diffuse Small Cleaved Cell Lymphoma / Stage IV Adult Hodgkin Lymphoma / Stage IV Adult Immunoblastic Large Cell Lymphoma / Stage IV Adult Lymphoblastic Lymphoma / Stage IV Adult T-Cell Leukemia/Lymphoma / Stage IV Childhood Hodgkin Lymphoma / Stage IV Chronic Lymphocytic Leukemia / Stage IV Cutaneous T-Cell Non-Hodgkin Lymphoma / Stage IV Grade 1 Follicular Lymphoma / Stage IV Grade 2 Follicular Lymphoma / Stage IV Grade 3 Follicular Lymphoma / Stage IV Mantle Cell Lymphoma / Stage IV Marginal Zone Lymphoma / Stage IV Mycosis Fungoides/Sezary Syndrome / Stage IV Small Lymphocytic Lymphoma / Testicular Lymphoma / Waldenstrom's Macroglobulinemia (WM)1
2CompletedTreatmentAccelerated Phase Chronic Myelogenous Leukemia / Adult Acute Lymphoblastic Leukemia in Remission / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Blastic Phase Chronic Myelogenous Leukemia / Childhood Acute Lymphoblastic Leukemia in Remission / Childhood Acute Myeloid Leukemia in Remission / Childhood Chronic Myelogenous Leukemia / Childhood Myelodysplastic Syndromes / Chronic Myelomonocytic Leukemia / De Novo Myelodysplastic Syndromes / Previously Treated Myelodysplastic Syndromes / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Recurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Acute Myeloid Leukemia / Secondary Myelodysplastic Syndromes / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
2CompletedTreatmentAccelerated Phase Chronic Myelogenous Leukemia / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Blastic Phase Chronic Myelogenous Leukemia / Childhood Acute Myeloid Leukemia in Remission / Childhood Chronic Myelogenous Leukemia / Childhood Myelodysplastic Syndromes / Chronic Phase Chronic Myelogenous Leukemia / De Novo Myelodysplastic Syndromes / Hematopoietic/Lymphoid Cancer / Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable / Previously Treated Myelodysplastic Syndromes / Recurrent Adult Acute Myeloid Leukemia / Recurrent Childhood Acute Myeloid Leukemia / Relapsing Chronic Myelogenous Leukemia1
2CompletedTreatmentAcute Lymphocytic Leukemia (ALL) / Aplastic Anaemia (AA) / Biphenotypic Leukemia / Chronic Lymphocytic Leukaemia (CLL) / Chronic Myeloid Leukemia (CML) / Hodgkins Disease (HD) / Leukemia Acute Myeloid Leukemia (AML) / Malignant Lymphomas / Myelodysplastic Syndromes / Plasma Cell Neoplasms1
2CompletedTreatmentAdult Acute Lymphoblastic Leukemia in Remission1
2CompletedTreatmentAmyotrophic Lateral Sclerosis (ALS)1
2CompletedTreatmentAtopic Dermatitis (AD)5
2CompletedTreatmentBlood Stem Cell Transplant Failure / Leukemias / Malignancies, Hematologic1
2CompletedTreatmentBronchial Asthma2
2CompletedTreatmentChronic Myelogenous Leukemia (CML) / Leukemias1
2CompletedTreatmentChronic Myeloproliferative Disorders / Graft Versus Host Disease (GVHD) / Leukemias / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases1
2CompletedTreatmentChronic Myeloproliferative Disorders / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes1
2CompletedTreatmentChronic Myeloproliferative Disorders / Leukemias / Myelodysplastic/Myeloproliferative Diseases1
2CompletedTreatmentCrohn's Disease (CD)1
2CompletedTreatmentDiabetes Mellitus, Insulin-Dependent1
2CompletedTreatmentDiabetes, Diabetes Mellitus Type 13
2CompletedTreatmentDiabetes, Diabetes Mellitus Type 1 / Hypoglycemia / Metabolic Diseases1
2CompletedTreatmentDisorder Related to Renal Transplantation1
2CompletedTreatmentGraft Versus Host Disease (GVHD)1
2CompletedTreatmentGraft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases / Secondary Myelofibrosis1
2CompletedTreatmentGraft Versus Host Disease (GVHD) / Leukemias / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Neoplasms1
2CompletedTreatmentGraft Versus Host Disease (GVHD) / Malignancies, Hematologic1
2CompletedTreatmentGraft Versus Host Disease (GVHD) / Malignant Lymphomas1
2CompletedTreatmentGraft Versus Host Disease (GVHD) / Transplantation, Bone Marrow2
2CompletedTreatmentHaematological Malignancies1
2CompletedTreatmentHeart Transplantation / Transplantation, Kidney / Transplantation, Liver1
2CompletedTreatmentHepatic Failure2
2CompletedTreatmentHepatitis C, Chronic1
2CompletedTreatmentHepatitis, Autoimmune1
2CompletedTreatmentHepatocellular,Carcinoma1
2CompletedTreatmentHodgkins Disease (HD)1
2CompletedTreatmentHodgkins Disease (HD) / Leukaemia, Lymphoblastic / Multiple Myeloma (MM) / Myelogenous Leukemia / Non-Hodgkin's Lymphoma (NHL)1
2CompletedTreatmentIgA Nephropathy1
2CompletedTreatmentKidney Diseases1
2CompletedTreatmentKidney Failure,Chronic / Transplantation, Kidney1
2CompletedTreatmentLeukemias / Lymphoproliferative Disorders / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Neoplasms1
2CompletedTreatmentLeukemias / Malignant Lymphomas1
2CompletedTreatmentLeukemias / Malignant Lymphomas / Multiple Myeloma (MM) / Myelodysplastic Syndromes / Myeloproliferative Neoplasms / Plasma Cell Neoplasms1
2CompletedTreatmentLeukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes2
2CompletedTreatmentLeukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases / Myeloproliferative Disorders / Renal Cancers1
2CompletedTreatmentLeukemias / Malignant Lymphomas / Myelodysplastic Syndrome1
2CompletedTreatmentLeukemias / Malignant Lymphomas / Myelodysplastic Syndromes2
2CompletedTreatmentLeukemias / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases1
2CompletedTreatmentLiver Diseases / Transplantation, Liver1
2CompletedTreatmentMalignancies, Hematologic1
2CompletedTreatmentMultiple Myeloma (MM) / Plasma Cell Neoplasms1
2CompletedTreatmentMultiple Myeloma and Plasma Cell Neoplasm1
2CompletedTreatmentNeoplasms, Malignant1
2CompletedTreatmentOral Chronic Graft-Versus-Host Disease1
2CompletedTreatmentOral Lichen Planus1
2CompletedTreatmentRenal Cancers2
2CompletedTreatmentRenal Failure3
2CompletedTreatmentSarcomas1
2CompletedTreatmentTransplant, Kidney1
2CompletedTreatmentTransplantation, Kidney4
2CompletedTreatmentTransplantation, Liver2
2CompletedTreatmentVulvar Lichen Sclerosus1
2Not Yet RecruitingTreatmentHematopoietic/Lymphoid Cancer1
2RecruitingPreventionAcute Lymphocytic Leukemia (ALL) / Chronic Lymphocytic Leukaemia (CLL) / Leukemia Acute Myeloid Leukemia (AML) / Myelodysplastic Syndrome / Non-Hodgkin's Lymphoma (NHL)1
2RecruitingPreventionAcute myeloid leukaemia (in remission) / Adult Acute Lymphoblastic Leukemia in Complete Remission / Chronic Myelogenous Leukemia, BCR-ABL1 Positive in Remission / Chronic Myelomonocytic Leukemia in Remission / Graft Versus Host Disease (GVHD) / Lymphoma, Hodgkins / Minimal Residual Disease / Myelodysplastic Syndrome / Myeloproliferative Neoplasms / Non-Hodgkin's Lymphoma (NHL) / Plasma Cell Myeloma / Severe Aplastic Anemia (SAA) / Waldenstrom's Macroglobulinemia (WM)1
2RecruitingPreventionAgnogenic Myeloid Metaplasia / Chronic Lymphocytic Leukaemia (CLL) / Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Follicular Lymphoma (FL) / Graft Versus Host Disease (GVHD) / Leukaemia, Acute / Lymphoma, Large B-Cell, Diffuse (DLBCL) / Mantle Cell Lymphoma (MCL) / Marginal Zone Lymphoma / Myelodysplastic Syndrome / Myeloproliferative Neoplasms / Small Lymphocytic Lymphoma (SLL)1
2RecruitingPreventionChronic Myeloid Leukemia (CML) / Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / Myelodysplastic Syndromes1
2RecruitingPreventionGraft Versus Host Disease (GVHD)1
2RecruitingPreventionGraft Versus Host Disease (GVHD) / Hematopoietic Stem Cell Transplantation (HSCT)1
2RecruitingSupportive CareChronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma / Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Follicular Lymphoma (FL) / Graft Versus Host Disease (GVHD) / Leukaemia, Acute / Lymphoma, Hodgkins / Lymphoma, Large B-Cell, Diffuse (DLBCL) / Mantle Cell Lymphoma (MCL) / Marginal Zone Lymphoma / Myelodysplastic Syndrome / Myeloproliferative Neoplasms / Recurrent Acute Myeloid Leukemia With Myelodysplasia-Related Changes / Recurrent Plasma Cell Myeloma / Refractory Plasma Cell Myeloma / Secondary Myelodysplastic Syndromes1
2RecruitingTreatmentAccelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Acute Biphenotypic Leukemia (ABL) / Acute Leukemias of Ambiguous Lineage / Acute Undifferentiated Leukemia (AUL) / Adult Acute Lymphoblastic Leukemia in Remission / Adult Acute Myeloid Leukemia in Remission / Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) / Childhood Acute Lymphoblastic Leukemia in Remission / Childhood Acute Myeloid Leukemia in Remission / Graft Versus Host Disease (GVHD) / Lymphoma, Lymphoblastic / Myelodysplastic Syndrome With Excess Blasts / Myelodysplastic Syndrome With Excess Blasts-1 / Myelodysplastic Syndrome With Excess Blasts-2 / RAEB-1 / RAEB-2 / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Recurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Acute Myeloid Leukemia / Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Refractory Anemia With Excess Blasts1
2RecruitingTreatmentAccelerated Phase Chronic Myelogenous Leukemia / Adult Acute Lymphoblastic Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Nasal Type Extranodal NK/T-Cell Lymphoma / Anaplastic Large Cell Lymphoma / Angioimmunoblastic T-Cell Lymphoma / Blastic Phase Chronic Myelogenous Leukemia / Childhood Acute Lymphoblastic Leukemia in Remission / Childhood Burkitt Lymphoma / Childhood Chronic Myelogenous Leukemia / Childhood Diffuse Large Cell Lymphoma / Childhood Immunoblastic Large Cell Lymphoma / Childhood Myelodysplastic Syndromes / Childhood Nasal Type Extranodal NK/T-cell Lymphoma / Chronic Myelomonocytic Leukemia / Chronic Phase Chronic Myelogenous Leukemia / Cutaneous B-Cell Non-Hodgkin Lymphoma / De Novo Myelodysplastic Syndromes / Essential Thrombocythemia (ET) / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Hepatosplenic T-Cell Lymphoma / Intraocular Lymphoma / Juvenile Myelomonocytic Leukemia / Nodal marginal zone B-cell lymphomas / Noncutaneous Extranodal Lymphoma / Peripheral T-Cell Lymphoma (PTCL) / Polycythemia Vera (PV) / Post-Transplant Lymphoproliferative Disorder / Previously Treated Myelodysplastic Syndromes / Primary Myelofibrosis / Recurrent Adult Acute Myeloid Leukemia / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Grade III Lymphomatoid Granulomatosis / Recurrent Adult Hodgkin's Lymphoma / Recurrent Adult Immunoblastic Large Cell Lymphoma / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Adult T-Cell Leukemia/Lymphoma / Recurrent Childhood Acute Myeloid Leukemia / Recurrent Childhood Anaplastic Large Cell Lymphoma / Recurrent Childhood Grade III Lymphomatoid Granulomatosis / Recurrent Childhood Large Cell Lymphoma / Recurrent Childhood Lymphoblastic Lymphoma / Recurrent Childhood Small Noncleaved Cell Lymphoma / Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Mycosis Fungoides/Sezary Syndrome / Recurrent Small Lymphocytic Lymphoma / Recurrent/Refractory Childhood Hodgkin Lymphoma / Refractory Anemia With Excess Blasts / Refractory Anemia With Excess Blasts in Transformation / Refractory Cytopenia With Multilineage Dysplasia / Refractory Hairy Cell Leukemia / Refractory Multiple Myeloma / Relapsing Chronic Myelogenous Leukemia / Secondary Acute Myeloid Leukemia / Small Intestine Lymphoma / Splenic Marginal Zone Lymphoma / T-Cell Large Granular Lymphocyte Leukemia / Testicular Lymphoma / Waldenstrom's Macroglobulinemia (WM)1
2RecruitingTreatmentAcute Biphenotypic Leukemia (ABL) / Acute Erythroid Leukemia in Remission / Acute Leukemia in Remission / Acute Megakaryoblastic Leukemia / Acute myeloid leukaemia (in remission) / Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome / Acute Myeloid Leukemia With FLT3/ITD Mutation / Acute Myeloid Leukemia With Inv(3)(q21q26.2) or t(3;3)(q21;q26.2); RPN1-EVI1 / Acute Myeloid Leukemia With Inv(3)(q21q26.2); RPN1-EVI1 / Acute Myeloid Leukemia With Multilineage Dysplasia / Acute Myeloid Leukemia With t(6;9)(p23;q34); DEK-NUP214 / Acute Undifferentiated Leukemia (AUL) / Adult Acute Lymphoblastic Leukemia in Complete Remission / B Acute Lymphoblastic Leukemia With t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1) / B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1 / Burkitt's Lymphoma / Childhood Acute Lymphoblastic Leukemia in Complete Remission / DS Stage II Plasma Cell Myeloma / DS Stage III Plasma Cell Myeloma / Myelodysplastic Syndrome / Recurrent Anaplastic Large Cell Lymphoma / Recurrent Diffuse Large B-Cell Lymphoma / Recurrent Follicular Lymphoma / Recurrent Hodgkin Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Plasma Cell Myeloma / Refractory Plasma Cell Myeloma / Secondary Acute Myeloid Leukemia / T Lymphoblastic Lymphoma1
2RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Chronic Myeloid Leukemia (CML) / Granulocytic Sarcoma / Juvenile Myelomonocytic Leukemia (JMML) / Leukemia Acute Myeloid Leukemia (AML) / Myelodysplastic Syndromes (MDS) / Non-Hodgkin's Lymphoma (NHL)1
2RecruitingTreatmentAcute Lymphocytic Leukemia (ALL) / Acute Myelogenous Leukaemia (AML) / Burkitt's Lymphoma / Chronic Lymphocytic Leukaemia (CLL) / Chronic Myelogenous Leukemia (CML) / Follicular Lymphoma (FL) / Hematological Diseases / Leukemia, Plasma Cell / Leukemia, Prolymphocytic / Lymphoma, B-Cell / Lymphoma, Lymphoblastic / Lymphoma, Mantle-Cell / Lymphoplasmacytic Lymphoma / Multiple Myeloma (MM) / Myelodysplastic Syndromes / Myeloproliferative Syndromes / Non-Hodgkin's Lymphoma (NHL) / Small Lymphocytic Lymphoma (SLL)1
2RecruitingTreatmentAcute Lymphocytic Leukemia (ALL) / Chronic Lymphocytic Leukaemia (CLL) / Chronic Myeloid Leukemia (CML) / Leukemia Acute Myeloid Leukemia (AML) / Lymphoma, Hodgkins / Multiple Myeloma (MM) / Myelodysplastic Syndrome / Myeloproliferative Syndromes / Non-Hodgkin's Lymphoma (NHL) / Other Diseases of Blood and Blood-Forming Organs1
2RecruitingTreatmentAcute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome / Adult Acute Lymphoblastic Leukemia in Remission / Adult Acute Megakaryoblastic Leukemia (M7) / Adult Acute Minimally Differentiated Myeloid Leukemia (M0) / Adult Acute Monoblastic Leukemia (M5a) / Adult Acute Monocytic Leukemia (M5b) / Adult Acute Myeloblastic Leukemia With Maturation (M2) / Adult Acute Myeloblastic Leukemia Without Maturation (M1) / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Adult Acute Myelomonocytic Leukemia (M4) / Adult Erythroleukemia (M6a) / Adult Pure Erythroid Leukemia (M6b) / Chronic Myelomonocytic Leukemia / Myelodysplastic Syndrome / Previously Treated Myelodysplastic Syndromes / Secondary Acute Myeloid Leukemia / Secondary Acute Myeloid Leukemia in Remission / Secondary Myelodysplastic Syndromes / Therapy-Related Myelodysplastic Syndrome1
2RecruitingTreatmentAcute myeloid leukaemia (in remission) / Aplastic Anaemia (AA) / Chronic Myelomonocytic Leukemia / Indolent Non-Hodgkin's Lymphomas / Leukemia Acute Myeloid Leukemia (AML) / Lymphoma, Hodgkins / Myelodysplastic Syndrome / Myeloproliferative Neoplasms / Neoplasms, Malignant / Plasma Cell Myeloma / Refractory Anemia / Refractory Anemia With Excess Blasts / Refractory Anemia With Ring Sideroblasts / Refractory Cytopenia With Multilineage Dysplasia / Refractory Cytopenia With Multilineage Dysplasia and Ring Sideroblasts1
2RecruitingTreatmentAdult Acute Lymphoblastic Leukemia in Remission / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Adult Nasal Type Extranodal NK/T-Cell Lymphoma / Aplastic Anaemia (AA) / Childhood Acute Lymphoblastic Leukemia in Remission / Childhood Acute Myeloid Leukemia in Remission / Childhood Myelodysplastic Syndromes / Chronic Eosinophilic Leukemia (CEL) / Chronic Myelomonocytic Leukemia / Chronic Neutrophilic Leukemia / Essential Thrombocythemia (ET) / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Juvenile Myelomonocytic Leukemia / Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable / Nodal marginal zone B-cell lymphomas / Polycythemia Vera (PV) / Previously Treated Myelodysplastic Syndromes / Primary Myelofibrosis / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Grade III Lymphomatoid Granulomatosis / Recurrent Adult Hodgkin's Lymphoma / Recurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Acute Myeloid Leukemia / Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Mycosis Fungoides/Sezary Syndrome / Recurrent Small Lymphocytic Lymphoma / Recurrent/Refractory Childhood Hodgkin Lymphoma / Refractory Anemia / Refractory Anemia With Ringed Sideroblasts / Refractory Hairy Cell Leukemia / Refractory Multiple Myeloma / Secondary Myelodysplastic Syndromes / Splenic Marginal Zone Lymphoma / T-Cell Large Granular Lymphocyte Leukemia / Urticaria Pigmentosa / Waldenstrom's Macroglobulinemia (WM)1
2RecruitingTreatmentAgnogenic Myeloid Metaplasia / Chronic Lymphocytic Leukaemia (CLL) / Chronic Myeloid Leukemia (CML) / Chronic Myelomonocytic Leukemia / Chronic Myeloproliferative Disorders / Essential Thrombocythemia (ET) / Leukemia, Plasma Cell / Leukemia, Prolymphocytic / Multiple Myeloma (MM) / Myelodysplastic Syndrome / Myelodysplastic Syndromes / Plasma Cell Dyscrasia / Plasma Cell Neoplasms / Polycythemia Vera (PV) / Small Lymphocytic Lymphoma (SLL)1
2RecruitingTreatmentAplastic Anaemia (AA) / Bone Marrow Failure / Immunosuppression / Severe Aplastic Anemia (SAA)1
2RecruitingTreatmentAplastic Anaemia (AA) / Immunodeficiency Syndrome / Non-Cancer Diagnosis / Severe Aplastic Anemia (SAA)1
2RecruitingTreatmentB-Cell Prolymphocytic Leukemia / Hypodiploidy / Leukemia, Plasma Cell / Loss of Chromosome 17p / Progression of Multiple Myeloma or Plasma Cell Leukemia / Recurrent Adult Hodgkin's Lymphoma / Recurrent Adult Non-Hodgkin Lymphoma / Recurrent Childhood Hodgkin Lymphoma / Recurrent Childhood Non-Hodgkin Lymphoma / Recurrent Chronic Lymphocytic Leukemia / Recurrent Plasma Cell Myeloma / Recurrent Small Lymphocytic Lymphoma / Refractory Childhood Hodgkin Lymphoma / Refractory Chronic Lymphocytic Leukemia / Refractory Non-Hodgkin's lymphoma / Refractory Plasma Cell Myeloma / Refractory Small Lymphocytic Lymphoma / T(14;16) / T(4;14) / T-Cell Prolymphocytic Leukemia / Waldenstrom's Macroglobulinemia (WM)1
2RecruitingTreatmentBone Marrow Failure Syndromes / Severe Aplastic Anemia (SAA)1
2RecruitingTreatmentChronic Myelogenous Leukemia (CML) / Chronic Myelomonocytic Leukemia (CMML) / Leukemia Acute Myeloid Leukemia (AML) / Myelodysplastic Syndromes (MDS)1
2RecruitingTreatmentChronic Myelomonocytic Leukemia / Leukemia Acute Myeloid Leukemia (AML) / Myelodysplastic Syndrome1
2RecruitingTreatmentDelayed Graft Function / Transplant, Kidney1
2RecruitingTreatmentEpidermolysis Bullosa1
2RecruitingTreatmentFibrolamellar Hepatocellular Carcinoma / Hepatocellular Carcinoma (Fibrolamellar Variant) / Hepatocellular,Carcinoma1
2RecruitingTreatmentFocal Segmental Glomerulosclerosis (FSGS) / Transplantation, Kidney1
2RecruitingTreatmentGraft Survival / HLA-mismatched Bone Marrow Transplantation / Myeloablative Conditioning / Transplantion, Bone Marrow1
2RecruitingTreatmentHaematological Malignancies1
2RecruitingTreatmentHematopoietic and Lymphoid Cell Neoplasm1
2RecruitingTreatmentLeukemia Acute Myeloid Leukemia (AML)1
2RecruitingTreatmentLeukemia Acute Myeloid Leukemia (AML) / Myelodysplastic Syndromes1
2RecruitingTreatmentLeukemias1
2RecruitingTreatmentNon-Hodgkin's Lymphoma (NHL)1
2RecruitingTreatmentNon-Malignant1
2RecruitingTreatmentOrthotopic Liver Transplant1
2RecruitingTreatmentPrimary Myelofibrosis / Secondary Myelofibrosis1
2RecruitingTreatmentSevere Aplastic Anemia (SAA)1
2RecruitingTreatmentSickle Cell Disorders1
2RecruitingTreatmentTransplant, Kidney1
2RecruitingTreatmentTransplantation, Kidney1
2SuspendedTreatmentCrohn's Disease (CD)1
2TerminatedPreventionAcute Leukemia in Remission / Leukemia, Myeloid, Accelerated-Phase / Leukemia, Myeloid, Chronic-Phase / Myelodysplastic Syndromes1
2TerminatedPreventionCardiac Allograft Vasculopathy / Heart Transplant Recipients1
2TerminatedPreventionGraft Versus Host Disease (GVHD)1
2TerminatedPreventionImmunosuppression in Solid Organ Transplant1
2TerminatedSupportive CareChronic Myeloproliferative Disorders / Graft Versus Host Disease (GVHD) / Leukemias / Lymphoproliferative Disorders / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Neoplasms1
2TerminatedTreatmentAcute Lymphoblastic Leukaemias (ALL) / Acute Myelocytic Leukemia / Chronic Myelocytic Leukemia / Granulocytic Sarcoma / Hodgkin's or Non-Hodgkin's Lymphoma / Juvenile Myelomonocytic Leukemia / Myelodysplastic Syndrome1
2TerminatedTreatmentAcute Lymphoblastic Leukaemias (ALL) / Acute Myelogenous Leukaemia (AML) / All / Chronic Lymphocytic Leukaemia (CLL) / CLL / Leukemia Acute Myeloid Leukemia (AML) / Leukemias / Lymphoma, Hodgkins / Malignancies, Hematologic / Malignant Lymphomas / Non-Hodgkin's Lymphoma (NHL) / Plasma Cell Myeloma1
2TerminatedTreatmentAplastic Anaemia (AA)1
2TerminatedTreatmentChronic Myeloproliferative Disorders / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Neoplasms / Unusual Cancers of Childhood1
2TerminatedTreatmentEnd-Stage Renal Disease (ESRD)1
2TerminatedTreatmentHaematological Malignancies1
2TerminatedTreatmentHaemoglobinopathies congenital / Hemoglobin SC Disease / Sickle Cell Disorders / Thalassaemic disorders / Thalassemia Major (TM)1
2TerminatedTreatmentLeukemias1
2TerminatedTreatmentLeukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myeloproliferative Disorders1
2TerminatedTreatmentLeukemias / Malignant Lymphomas / Myelodysplastic Syndrome1
2TerminatedTreatmentLeukemias / Malignant Lymphomas / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases1
2TerminatedTreatmentLeukemias / Malignant Lymphomas / Myeloproliferative Disorders / Plasma Cell Myeloma1
2TerminatedTreatmentMalignant Lymphomas1
2TerminatedTreatmentNew Onset Diabetes Mellitus After Renal Transplantation1
2TerminatedTreatmentPrimary Renal Allograft Candidate / Transplantation, Kidney1
2TerminatedTreatmentPrimary Simultaneous Kidney and Pancreas Allograft Candidates / Simultaneous Kidney and Pancreas Transplantation1
2TerminatedTreatmentRefractory Multiple Myeloma / Stage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma1
2TerminatedTreatmentSickle Cell Disorders1
2TerminatedTreatmentTransplantation, Kidney / Transplantation, Renal1
2Unknown StatusSupportive CareAcute Lymphocytic Leukemia (ALL) / Acute Myelogenous Leukaemia (AML) / Myelodysplastic Syndrome1
2Unknown StatusTreatmentAcute Lymphocytic Leukemia (ALL) / Acute Myelogenous Leukaemia (AML) / Malignant Lymphomas / Multiple Myeloma (MM) / Myelodysplastic Syndrome1
2Unknown StatusTreatmentChronic Myeloproliferative Disorders / Leukemias / Malignant Lymphomas / Multiple Myeloma and Malignant Plasma Cell Neoplasms / Myelodysplastic Syndromes / Precancerous/Nonmalignant Condition / Secondary Myelofibrosis1
2Unknown StatusTreatmentConjunctivitis, Seasonal Allergic1
2Unknown StatusTreatmentDisseminated Sclerosis1
2Unknown StatusTreatmentKidney Diseases1
2Unknown StatusTreatmentLeukemias / Malignant Lymphomas1
2Unknown StatusTreatmentNephritis, Lupus1
2WithdrawnSupportive CareGraft Versus Host Disease (GVHD) / Leukemias1
2WithdrawnTreatmentAccelerated Phase Chronic Myelogenous Leukemia / Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome / Adult Acute Lymphoblastic Leukemia in Remission / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Adult Nasal Type Extranodal NK/T-Cell Lymphoma / Anaplastic Large Cell Lymphoma / Angioimmunoblastic T-Cell Lymphoma / Blastic Phase Chronic Myelogenous Leukemia / Cutaneous B-Cell Non-Hodgkin Lymphoma / De Novo Myelodysplastic Syndromes / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Hepatosplenic T-Cell Lymphoma / Intraocular Lymphoma / Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable / Nodal marginal zone B-cell lymphomas / Noncutaneous Extranodal Lymphoma / Peripheral T-Cell Lymphoma (PTCL) / Post-Transplant Lymphoproliferative Disorder / Previously Treated Myelodysplastic Syndromes / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Grade III Lymphomatoid Granulomatosis / Recurrent Adult Hodgkin's Lymphoma / Recurrent Adult Immunoblastic Large Cell Lymphoma / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Adult T-Cell Leukemia/Lymphoma / Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Mycosis Fungoides/Sezary Syndrome / Recurrent Small Lymphocytic Lymphoma / Refractory Chronic Lymphocytic Leukemia / Refractory Hairy Cell Leukemia / Refractory Multiple Myeloma / Relapsing Chronic Myelogenous Leukemia / Secondary Acute Myeloid Leukemia / Secondary Myelodysplastic Syndromes / Small Intestine Lymphoma / Splenic Marginal Zone Lymphoma / T-Cell Large Granular Lymphocyte Leukemia / Testicular Lymphoma / Waldenstrom's Macroglobulinemia (WM)1
2WithdrawnTreatmentAge-Related Macular Degeneration (ARMD)1
2WithdrawnTreatmentAnemias / Chronic Myeloproliferative Disorders / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases1
2WithdrawnTreatmentColitis / Cytokines / Drug Evaluation / Hermanski-Pudlak Syndrome / Lymphocytes1
2WithdrawnTreatmentDiabetes, Diabetes Mellitus Type 11
2WithdrawnTreatmentNeuroblastomas1
2WithdrawnTreatmentRenal Cancers1
2WithdrawnTreatmentScleroderma, Systemic1
2, 3Active Not RecruitingTreatmentChronic Graft Versus Host Disease1
2, 3Active Not RecruitingTreatmentTransplantation, Kidney1
2, 3CompletedPreventionGraft Versus Host Disease (GVHD)1
2, 3CompletedTreatmentGlomerulonephritis minimal lesion1
2, 3CompletedTreatmentGraft Versus Host Disease (GVHD) / Leukemias / Myelodysplastic Syndromes1
2, 3CompletedTreatmentMaintenance With Tacrolimus / Pediatric Patients / Transplantation, Kidney1
2, 3CompletedTreatmentVernal Keratoconjunctivitis1
2, 3RecruitingTreatmentAmputation, Traumatic/Surgery / Amputations / Penis/Injuries / Penis/Surgery / Penis/Transplantation / Traumatic Amputations / Urologic Surgical Procedures, Male / Wounds and Injuries1
2, 3RecruitingTreatmentDelayed Graft Function1
2, 3RecruitingTreatmentLiver Diseases1
2, 3TerminatedTreatmentFollicular Lymphoma (FL) / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma1
2, 3TerminatedTreatmentGraft Failure / Ischemia Reperfusion Injury / Poor Graft Quality / Terminal Liver Disease / Transplant dysfunction1
2, 3TerminatedTreatmentGraft Versus Host Disease (GVHD)1
2, 3TerminatedTreatmentHypertensive1
2, 3TerminatedTreatmentPigmentation Disorders / Vitiligo1
2, 3Unknown StatusTreatmentDermatomyositis / Pneumonitis, Interstitial / Polymyositis1
2, 3Unknown StatusTreatmentRasmussen's Encephalitis1
3Active Not RecruitingTreatmentB-cell Childhood Acute Lymphoblastic Leukemia / Childhood Acute Lymphoblastic Leukemia in Remission / Graft Versus Host Disease (GVHD) / L1 Childhood Acute Lymphoblastic Leukemia / L2 Childhood Acute Lymphoblastic Leukemia / T-cell Childhood Acute Lymphoblastic Leukemia1
3Active Not RecruitingTreatmentDisorder Related to Bone Marrow Transplantation / Leukemias / Transplantation Infection1
3Active Not RecruitingTreatmentEnd Stage Renal Disease (ESRD) / Rejection of Renal Transplant1
3Active Not RecruitingTreatmentTransplantation, Kidney2
3CompletedNot AvailablePharmacokinetics / Tacrolimus1
3CompletedNot AvailableTransplantation, Liver1
3CompletedBasic ScienceRenal Failure1
3CompletedPreventionGraft Versus Host Disease (GVHD) / Survival1
3CompletedPreventionImmunosuppression / Obliterative Bronchiolitis1
3CompletedPreventionRenal Failure1
3CompletedPreventionTransplantation, Kidney6
3CompletedPreventionTransplantation, Liver3
3CompletedSupportive CareGraft Versus Host Disease (GVHD)1
3CompletedTreatmentAcute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome / Acute Myeloid Leukemia/Transient Myeloproliferative Disorder / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Childhood Acute Myeloid Leukemia in Remission / Childhood Myelodysplastic Syndromes / De Novo Myelodysplastic Syndromes / Myelodysplastic Syndrome With Isolated Del(5q) / Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable / Previously Treated Myelodysplastic Syndromes / Recurrent Adult Acute Myeloid Leukemia / Recurrent Childhood Acute Myeloid Leukemia / Secondary Acute Myeloid Leukemia / Secondary Myelodysplastic Syndromes1
3CompletedTreatmentAtopic Dermatitis (AD)4
3CompletedTreatmentChronic Hepatitis C Infection / Liver Cirrhosis1
3CompletedTreatmentConjunctivitis / Keratoconjunctivitis1
3CompletedTreatmentDiabetes, Diabetes Mellitus Type 11
3CompletedTreatmentGlomerulonephritis minimal lesion2
3CompletedTreatmentGlomerulonephritis minimal lesion / Kidney Diseases / Tacrolimus1
3CompletedTreatmentGlomerulonephritis, Membranous / Nephritis, Lupus1
3CompletedTreatmentHeart Diseases / Heart Transplantation1
3CompletedTreatmentHeart Transplantation / Transplantation, Kidney / Transplantation, Liver1
3CompletedTreatmentHepatocellular,Carcinoma1
3CompletedTreatmentHost vs Graft Reaction / Transplantation Immunology / Transplantation, Kidney1
3CompletedTreatmentHost vs Graft Reaction / Transplantation Immunology / Transplantation, Liver1
3CompletedTreatmentInduction Phase / Kidney Diseases / Maintenance Phase / Nephritis, Lupus / Tacrolimus1
3CompletedTreatmentKidney Diseases1
3CompletedTreatmentKidney-Pancreas Transplantation1
3CompletedTreatmentLeukemia, Lymphocytic, Acute / Leukemia, Myelocytic, Acute / Leukemia,Myeloid, Chronic / Myelodysplastic Syndromes1
3CompletedTreatmentLiver Transplant Recipients1
3CompletedTreatmentLymphoma, Hodgkins / Non-Hodgkin's Lymphoma (NHL)1
3CompletedTreatmentMyasthenia Gravis3
3CompletedTreatmentNephritis, Lupus2
3CompletedTreatmentPsoriasis3
3CompletedTreatmentRenal Failure2
3CompletedTreatmentRenal Failure / Tremors1
3CompletedTreatmentRheumatoid Arthritis2
3CompletedTreatmentSkin Cancers / Transplantation, Kidney1
3CompletedTreatmentTransplant, Kidney2
3CompletedTreatmentTransplant; Failure, Kidney1
3CompletedTreatmentTransplantation, Kidney5
3CompletedTreatmentTransplantation, Liver7
3CompletedTreatmentTransplantation, Renal1
3CompletedTreatmentTransplantations3
3CompletedTreatmentUlcerative Colitis (UC)2
3Enrolling by InvitationNot AvailableDiabetes, Diabetes Mellitus Type 1 / Islet Transplantation1
3Not Yet RecruitingPreventionTransplantation, Liver1
3Not Yet RecruitingTreatmentMedication Adherence1
3Not Yet RecruitingTreatmentUlcerative Colitis (UC)1
3RecruitingPreventionAcute Lymphocytic Leukemia (ALL) / Leukemia Acute Myeloid Leukemia (AML) / Myelodysplastic Syndrome1
3RecruitingPreventionLeukaemia, Acute / Myelodysplasia1
3RecruitingSupportive CareAcute Biphenotypic Leukemia (ABL) / Acute Lymphoblastic Leukaemias (ALL) / Chronic Lymphocytic Leukaemia (CLL) / Chronic Myelogenous Leukemia (CML) / Hodgkins Disease (HD) / Leukemia Acute Myeloid Leukemia (AML) / Multiple Myeloma (MM) / Myelodysplastic Syndrome / Myeloproliferative Neoplasms / Non-Hodgkin's Lymphoma (NHL)1
3RecruitingTreatmentAbsolute Uterine Factor Infertility / Infertility, Female / Mayer Rokitansky Kuster Hauser Syndrome / Mullerian Aplasia / Uterus Absence, Acquired / Uterus; Absence, Congenital1
3RecruitingTreatmentChronic Kidney Disease (CKD)1
3RecruitingTreatmentDiabetes, Diabetes Mellitus Type 11
3RecruitingTreatmentFailing Renal Allograft / Transplant, Kidney1
3RecruitingTreatmentGlomerulonephritis membranous1
3RecruitingTreatmentGraft Versus Host Disease (GVHD)1
3RecruitingTreatmentNephritis, Lupus1
3RecruitingTreatmentSevere Seborrheic Dermatitis1
3RecruitingTreatmentTransplantation, Liver1
3RecruitingTreatmentVitiligo1
3SuspendedTreatmentTransplant, Kidney1
3TerminatedPreventionEvidence of Liver Transplantation1
3TerminatedPreventionTransplantation, Lung1
3TerminatedTreatmentAtherosclerosis / Renal Failure1
3TerminatedTreatmentEnd-Stage Renal Disease (ESRD) / Transplantation, Kidney1
3TerminatedTreatmentFunction of Renal Transplant1
3TerminatedTreatmentNephritis, Lupus1
3WithdrawnPreventionTransplantation, Renal1
3WithdrawnTreatmentNephritis, Lupus1
4Active Not RecruitingPreventionHeart Transplantation / Transplantation, Kidney / Transplantation, Liver1
4Active Not RecruitingSupportive CareCardiovascular Disease (CVD) / Immunosuppression / Transplantation, Kidney1
4Active Not RecruitingSupportive CareRenal Diseases / Transplant, Kidney1
4Active Not RecruitingTreatmentChronic Kidney Disease (CKD) / End Stage Renal Disease (ESRD) / Hemodialysis-dependent patients / Renal Replacement Therapies / Transplantation, Renal1
4Active Not RecruitingTreatmentGlomerulonephritis, Membranous / Nephrotic Syndrome Secondary to Idiopathic Membranous Glomerulonephritis1
4Active Not RecruitingTreatmentPancreas Transplantation / Transplantation, Kidney1
4Active Not RecruitingTreatmentTransplantation, Renal1
4CompletedNot AvailableEnd Stage Renal Disease (ESRD)1
4CompletedNot AvailableFunction of Renal Transplant1
4CompletedBasic ScienceEnd Stage Renal Disease (ESRD)1
4CompletedBasic SciencePharmacokinetics Study in de Novo Kidney Transplantation1
4CompletedHealth Services ResearchKidney Failure,Chronic1
4CompletedPreventionDisorder Related to Cardiac Transplantation1
4CompletedPreventionDisorder Related to Renal Transplantation1
4CompletedPreventionErectile Dysfunction (ED) / Prostate Cancer1
4CompletedPreventionHeart Transplantation / Transplantation, Kidney / Transplantation, Liver1
4CompletedPreventionKidney Transplantion / Renal Transplantion1
4CompletedPreventionPost Transplant Diabetes Mellitus1
4CompletedPreventionRejection, Transplant / Renal Allograft Recipients / Transplant, Kidney1
4CompletedPreventionRejection, Transplant / Transplantation, Kidney1
4CompletedPreventionTransplant, Kidney1
4CompletedPreventionTransplantation, Kidney3
4CompletedPreventionTransplantation, Liver1
4CompletedPreventionTransplantation, Renal1
4CompletedSupportive CareChronic Hepatitis C Infection / Renal Allograft1
4CompletedTreatmentAdult Primary Kidney Transplantation1
4CompletedTreatmentAtopic Dermatitis (AD)8
4CompletedTreatmentChronic Hepatitis C Infection1
4CompletedTreatmentChronic Hepatitis C Infection / End Stage Liver Diseases / Transplantation, Liver1
4CompletedTreatmentChronic Hepatitis C Infection / Transplantation, Liver1
4CompletedTreatmentChronic Renal Allograft Failure / Transplantation, Renal1
4CompletedTreatmentChronic Renal Diseases1
4CompletedTreatmentChronic Renal Failure (CRF)1
4CompletedTreatmentComplication of Transplant1
4CompletedTreatmentComplications of Transplanted Organs and Tissue / Diabetes Mellitus Nos New Onset1
4CompletedTreatmentDe Novo Kidney Transplantation1
4CompletedTreatmentDiabetic Nephropathies / Transplant, Kidney / Type 2 Diabetes Mellitus1
4CompletedTreatmentDisorder Related to Renal Transplantation / Infections, Cytomegalovirus1
4CompletedTreatmentDry Eye Syndrome (DES) / Sjögren's Syndrome1
4CompletedTreatmentEnd Stage Renal Disease (ESRD)2
4CompletedTreatmentEnd-Stage Renal Disease (ESRD)1
4CompletedTreatmentGlomerulonephritis minimal lesion1
4CompletedTreatmentGraft Versus Host Disease (GVHD)1
4CompletedTreatmentGraft Versus Host Disease (GVHD) / Renal Failure1
4CompletedTreatmentHenoch-Schönlein Purpura Nephritis1
4CompletedTreatmentImmunosuppression1
4CompletedTreatmentInfections, Cytomegalovirus / Renal Transplant Failure / Transplant; Complication, Rejection1
4CompletedTreatmentIschemia Reperfusion Injury1
4CompletedTreatmentKidney Diseases1
4CompletedTreatmentKidney Failure,Chronic / Renal Insufficiency,Chronic / Transplantation, Kidney1
4CompletedTreatmentKidney Pancreas Transplant / Transplant, Kidney1
4CompletedTreatmentKidney Transplant Recipients / Liver Transplant Recipients1
4CompletedTreatmentKidney Transplantation, Renal Transplantation1
4CompletedTreatmentLiver Cirrhosis / Liver Transplant Disorder1
4CompletedTreatmentLupus Erythematosus, Systemic / Nephritis, Lupus1
4CompletedTreatmentMCNS / Minimal Change Nephrotic Syndrome (MCNS)1
4CompletedTreatmentModerate/Severe Atopic Dermatitis1
4CompletedTreatmentNephritis, Lupus3
4CompletedTreatmentOrgan or Tissue Transplant; Complications1
4CompletedTreatmentPityriasis Alba1
4CompletedTreatmentPolyomavirus Infections1
4CompletedTreatmentRejection, Transplant / Renal Failure / Transplantation, Kidney1
4CompletedTreatmentRheumatoid Arthritis4
4CompletedTreatmentSeborrheic Dermatitis1
4CompletedTreatmentSkin Inflammation1
4CompletedTreatmentStable Renal Recipients / Transplantation, Kidney / Transplantation, Renal1
4CompletedTreatmentTransplant, Kidney4
4CompletedTreatmentTransplantation, Kidney12
4CompletedTreatmentTransplantation, Kidney / Transplantation, Liver1
4CompletedTreatmentTransplantation, Kidney / Transplantations1
4CompletedTreatmentTransplantation, Liver7
4CompletedTreatmentTransplantation, Renal5
4CompletedTreatmentUveitis1
4CompletedTreatmentDe Novo Liver Transplant Subjects1
4Not Yet RecruitingOtherKidney / Pharmacokinetics / Transplantations1
4Not Yet RecruitingTreatmentCardiac Transplant Rejection / Kidney Transplant Rejection / Liver Transplant Rejection1
4Not Yet RecruitingTreatmentDisorder Related to Renal Transplantation / Immunosuppression Related Infectious Disease / Virus Diseases1
4Not Yet RecruitingTreatmentImmunosuppression After Renal Transplantation / Transplant, Kidney1
4Not Yet RecruitingTreatmentKidney Transplant Failure and Rejection1
4Not Yet RecruitingTreatmentRenal Transplant Patients1
4Not Yet RecruitingTreatmentTransplantation, Liver1
4RecruitingOtherTransplantation, Liver1
4RecruitingPreventionEnd-Stage Renal Disease (ESRD)1
4RecruitingTreatmentAdherence to Medication Regime1
4RecruitingTreatmentCYCLOSPORINE/TACROLIMUS1
4RecruitingTreatmentDrug Interaction Potentiation / Transplantation, Kidney1
4RecruitingTreatmentEBV / Transplant; Failure, Kidney1
4RecruitingTreatmentEnd Stage Renal Disease (ESRD)1
4RecruitingTreatmentFunction of Renal Transplant1
4RecruitingTreatmentGlomerulonephritis minimal lesion2
4RecruitingTreatmentHeart Failure, Unspecified1
4RecruitingTreatmentHepatitis B Virus Associated Nephrotic Syndrome1
4RecruitingTreatmentHepatocellular,Carcinoma1
4RecruitingTreatmentImmunosuppression1
4RecruitingTreatmentImplant or Graft; Rejection1
4RecruitingTreatmentKidney Transplant Rejection / Other Complications of Kidney Transplant1
4RecruitingTreatmentLiver Dysfunction1
4RecruitingTreatmentNephritis, Lupus1
4RecruitingTreatmentRheumatoid Arthritis1
4RecruitingTreatmentThalassemia Major (TM)1
4RecruitingTreatmentTransplant, Kidney1
4RecruitingTreatmentTransplantation, Kidney2
4RecruitingTreatmentVernal Keratoconjunctivitis1
4RecruitingTreatmentVitiligo1
4TerminatedPreventionChronic Hepatitis C Infection / Transplantation, Liver1
4TerminatedPreventionImpaired Renal Function1
4TerminatedPreventionSkin Cancers / Transplantation, Kidney1
4TerminatedPreventionTransplantation, Renal1
4TerminatedTreatmentDiabetes Mellitus (DM)1
4TerminatedTreatmentImmunosuppression1
4TerminatedTreatmentKidney Transplant Failure and Rejection1
4TerminatedTreatmentKidney Transplant Recipients1
4TerminatedTreatmentKidney Transplant Rejection1
4TerminatedTreatmentLung and Heart-lung Transplantation1
4TerminatedTreatmentNephritis, Lupus1
4TerminatedTreatmentTransplantation, Kidney2
4TerminatedTreatmentTransplants and Implants1
4Unknown StatusNot AvailableNew Onset Diabetes After Transplant / Transplantation, Kidney1
4Unknown StatusBasic ScienceTransplantation, Kidney1
4Unknown StatusPreventionEnd-stage Renal Failure (ESRF) / Rejection, Transplant1
4Unknown StatusPreventionImmunosuppression / Transplantation, Kidney / Transplantations2
4Unknown StatusPreventionKidney Transplant Recipients1
4Unknown StatusPreventionKidney; Complications, Allograft1
4Unknown StatusTreatmentDe Novo Transplant Disease2
4Unknown StatusTreatmentDelayed Graft Function / Slow Graft Function-defined at Creatinine >= 3.0 by Post-op Day 5 Without Requiring Dialysis / Transplant, Kidney1
4Unknown StatusTreatmentDermatitis, Contact / Dermatitis, Occupational1
4Unknown StatusTreatmentHepatitis1
4Unknown StatusTreatmentImmunosuppression / Liver Diseases / Transplantation, Liver1
4Unknown StatusTreatmentImmunosuppression / Transplant, Kidney1
4Unknown StatusTreatmentInfections, Cytomegalovirus1
4Unknown StatusTreatmentKidney Diseases1
4Unknown StatusTreatmentKidney Diseases / Rejection, Transplant1
4Unknown StatusTreatmentPediatric Liver Transplantation1
4Unknown StatusTreatmentTransplantation, Kidney3
4Unknown StatusTreatmentVitiligo2
4WithdrawnNot AvailablePlasmapheresis / Transplantation, Kidney1
4WithdrawnTreatmentAtopic Dermatitis (AD)1
4WithdrawnTreatmentKidney Graft Dysfunction1
4WithdrawnTreatmentLiving Donor Kidney Transplants Patients1
Not AvailableActive Not RecruitingNot AvailableGlomerulonephritis minimal lesion1
Not AvailableActive Not RecruitingNot AvailableInterstitial Pneumonia Associated With Polymyositis/Dermatomyositis1
Not AvailableActive Not RecruitingNot AvailableNephritis, Lupus1
Not AvailableActive Not RecruitingNot AvailableTransplant, Kidney / Transplantation, Liver1
Not AvailableActive Not RecruitingPreventionTransplantation, Liver1
Not AvailableActive Not RecruitingTreatmentEnd Stage Renal Failure With Renal Transplant1
Not AvailableApproved for MarketingNot AvailableRenal Failure1
Not AvailableAvailableNot AvailableComplete DiGeorge Anomaly / Complete DiGeorge Syndrome / DiGeorge Anomaly / DiGeorge's syndrome1
Not AvailableCompletedNot AvailableHealthy Volunteers4
Not AvailableCompletedNot AvailablePediatric Heart Transplant Recipients / Pediatric Heart Transplantation1
Not AvailableCompletedNot AvailableRheumatoid Arthritis1
Not AvailableCompletedNot AvailableTransplantation, Liver1
Not AvailableCompletedNot AvailableTransplantation, Renal2
Not AvailableCompletedNot AvailableThe Maintenance Phase After Kidney Transplantation1
Not AvailableCompletedPreventionAbsence; Kidney1
Not AvailableCompletedPreventionEarly Allograft Dysfunction / Hyperfibrinolysis / Ischemic Reperfusion Injury / Transplantation, Liver1
Not AvailableCompletedScreeningRenal Failure, Chronic1
Not AvailableCompletedScreeningTransplantation, Kidney1
Not AvailableCompletedSupportive CareChronic Myeloproliferative Disorders / Graft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Neoplasms1
Not AvailableCompletedTreatmentAdult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Childhood Acute Myeloid Leukemia in Remission / Childhood Myelodysplastic Syndromes / De Novo Myelodysplastic Syndromes / Essential Thrombocythemia (ET) / Myelodysplastic Syndrome With Isolated Del(5q) / Polycythemia Vera (PV) / Previously Treated Myelodysplastic Syndromes / Primary Myelofibrosis / Recurrent Adult Acute Myeloid Leukemia / Recurrent Childhood Acute Myeloid Leukemia / Secondary Acute Myeloid Leukemia / Secondary Myelodysplastic Syndromes / Secondary Myelofibrosis / Untreated Adult Acute Myeloid Leukemia / Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies1
Not AvailableCompletedTreatmentChronic Allograft Nephropathy (CAN) / Transplantation, Kidney1
Not AvailableCompletedTreatmentChronic Myeloproliferative Disorders / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes1
Not AvailableCompletedTreatmentEffects of Immunosuppressant Therapy / Evidence of Liver Transplantation1
Not AvailableCompletedTreatmentGraft Versus Host Disease (GVHD) / Mucositis1
Not AvailableCompletedTreatmentHigh Model for End-Stage Liver Disease (MELD) Score1
Not AvailableCompletedTreatmentIdiopathic Membranous Nephropathy1
Not AvailableCompletedTreatmentImmunosuppression1
Not AvailableCompletedTreatmentLiving Donors / Transplantation, Kidney1
Not AvailableCompletedTreatmentModerate to Severe Atopic Dermatitis1
Not AvailableCompletedTreatmentParaneoplastic Syndromes1
Not AvailableCompletedTreatmentPsoriasis Vulgaris1
Not AvailableCompletedTreatmentTransplant, Kidney1
Not AvailableCompletedTreatmentTransplantation, Kidney2
Not AvailableNo Longer AvailableNot AvailableDiabetes, Diabetes Mellitus Type 12
Not AvailableNo Longer AvailableNot AvailableLeukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Precancerous Conditions / Secondary Myelofibrosis1
Not AvailableNot Yet RecruitingNot AvailableAcute Rejection of Renal Transplant / Biopsy Proven Acute Rejection (BPAR) / Bone Diseases / Cardiovascular Risk Factors / Graft Failure / HLA Antibody Production / Infection NOS / Mortality / Non-HLA Antibody Production / Post Transplant Diabetes Mellitus / Quality of Life1
Not AvailableNot Yet RecruitingTreatmentHeart Transplantation1
Not AvailableRecruitingNot AvailableBiliary Concentration of Tacrolimus1
Not AvailableRecruitingNot AvailableKidney; Complications, Allograft / Transplantation Infection1
Not AvailableRecruitingNot AvailableTransplantation, Kidney2
Not AvailableRecruitingPreventionImmunosuppression / Renal Failure1
Not AvailableRecruitingSupportive CarePrimary Myelofibrosis / Secondary Myelofibrosis1
Not AvailableRecruitingTreatmentAcute Graft Rejection / Diabetes1
Not AvailableRecruitingTreatmentAdult Acute Lymphoblastic Leukemia in Remission / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / De Novo Myelodysplastic Syndromes / Previously Treated Myelodysplastic Syndromes / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Secondary Myelodysplastic Syndromes / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Adult Acute Myeloid Leukemia1
Not AvailableRecruitingTreatmentAgnogenic Myeloid Metaplasia / All / Amyloidosis / Bone Marrow Failure Syndromes / Chronic Myelocytic Leukemia / Haemoglobinopathies congenital / HL / Leukemia Acute Myeloid Leukemia (AML) / Multiple Myeloma (MM) / NHL / Smith-Magenis Syndrome1
Not AvailableRecruitingTreatmentAllografts / Transplantation, Lung1
Not AvailableRecruitingTreatmentDisorder Related to Renal Transplantation / Effects of Immunosuppressant Therapy1
Not AvailableRecruitingTreatmentGraft Versus Host Disease (GVHD) / Hematopoietic/Lymphoid Cancer1
Not AvailableRecruitingTreatmentImmunosuppression1
Not AvailableRecruitingTreatmentLiver Transplantation, Child1
Not AvailableRecruitingTreatmentMalignancies, Hematologic1
Not AvailableRecruitingTreatmentMalignant Lymphomas1
Not AvailableRecruitingTreatmentOcular Penetration of Topical Tacrolimus1
Not AvailableRecruitingTreatmentRenal Transplanted Recipients1
Not AvailableRecruitingTreatmentTransplantation, Kidney1
Not AvailableTerminatedNot AvailableDried Blood Spot / Transplant Patients / Validation1
Not AvailableTerminatedTreatmentOral Lichen Planus1
Not AvailableTerminatedTreatmentPolycystic Liver Disease (PLD)1
Not AvailableUnknown StatusNot AvailableIdiopathic Membranous Nephropathy1
Not AvailableUnknown StatusTreatmentBlood and Marrow Transplant (BMT) / Graft Versus Host Disease (GVHD)1
Not AvailableUnknown StatusTreatmentCalcineurin Inhibitor Toxicity / Chronic Allograft Injury1
Not AvailableUnknown StatusTreatmentChronic Myeloproliferative Disorders / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Neoplasms / Renal Cancers1
Not AvailableUnknown StatusTreatmentTransplantation, Renal1
Not AvailableUnknown StatusTreatmentMicroRNA Profiles1
Not AvailableWithdrawnTreatmentGlomerulosclerosis, Focal Segmental1

Pharmacoeconomics

Manufacturers
  • Astellas pharma us inc
  • Dr reddys laboratories ltd
  • Sandoz inc
  • Watson laboratories inc
  • Astellas Pharma US
Packagers
Dosage forms
FormRouteStrength
Capsule, extended releaseOral0.5 mg
Capsule, extended releaseOral1 mg
Capsule, extended releaseOral3 mg
Capsule, extended releaseOral5 mg
Capsule, coated, extended releaseOral.5 mg/1
Capsule, coated, extended releaseOral1 mg/1
Capsule, coated, extended releaseOral5 mg/1
Tablet, extended releaseOral0.75 mg
Tablet, extended releaseOral1 mg
Tablet, extended releaseOral4 mg
Tablet, extended releaseOral.75 mg/1
Tablet, extended releaseOral1 mg/1
Tablet, extended releaseOral4 mg/1
CapsuleOral.5 mg/1
CapsuleOral1 mg/1
CapsuleOral5 mg/1
GranuleOral0.2 mg
GranuleOral1 mg
CapsuleOral0.5 mg
CapsuleOral1 mg
CapsuleOral5 mg
Capsule, gelatin coatedOral1 mg/1
Injection, solutionIntravenous5 mg/mL
SolutionIntravenous5 mg
OintmentCutaneous0.03 %
OintmentCutaneous0.1 %
OintmentTopical0.03 %
OintmentTopical0.1 %
Capsule, gelatin coatedOral.5 mg/1
Capsule, gelatin coatedOral5 mg/1
OintmentTopical.3 mg/g
OintmentTopical1 mg/g
Prices
Unit descriptionCostUnit
Tacrolimus micronized powder2800.0USD g
Protopic 0.1% Ointment 60 gm Tube255.34USD tube
Protopic 0.03% Ointment 60 gm Tube251.17USD tube
Prograf 5 mg/ml ampule163.94USD ml
Protopic 0.03% Ointment 30 gm Tube132.99USD tube
Protopic 0.1% Ointment 30 gm Tube124.42USD tube
Prograf 5 mg capsule24.26USD capsule
Tacrolimus anhydrous 5 mg cap22.3USD each
Prograf 1 mg capsule4.85USD capsule
Tacrolimus 1 mg capsule4.64USD capsule
Tacrolimus anhydrous 1 mg cap4.46USD each
Protopic 0.1% ointment4.17USD g
Protopic 0.03% ointment4.09USD g
Prograf 0.5 mg capsule2.43USD capsule
Tacrolimus anhydrous 0.5 mg cap2.23USD each
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5665727No1994-09-092014-09-09Us
US5260301No1994-02-282011-02-28Us
CA2037408No2002-12-172011-03-01Canada
CA1338491No1996-07-302013-07-30Canada
US6884433No1999-03-252019-03-25Us
US6576259No1999-03-252019-03-25Us
US8551522No1999-03-252019-03-25Us
US6440458No1999-03-252019-03-25Us
US9161907No2004-08-302024-08-30Us
US8889186No2004-08-302024-08-30Us
US8623411No2004-08-302024-08-30Us
US8486993No2004-08-302024-08-30Us
US8889185No2004-08-302024-08-30Us
US8664239No2008-05-302028-05-30Us
US8586084No2004-08-302024-08-30Us
US8685998No2008-05-302028-05-30Us
US8623410No2004-08-302024-08-30Us
US8617599No2004-08-302024-08-30Us
US7994214No2004-08-302024-08-30Us
US8591946No2004-08-302024-08-30Us
US9549918No2008-05-302028-05-30Us

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)126 °CNot Available
water solubilityInsolubleFDA label
logP3.3Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00402 mg/mLALOGPS
logP3.19ALOGPS
logP5.59ChemAxon
logS-5.3ALOGPS
pKa (Strongest Acidic)9.96ChemAxon
pKa (Strongest Basic)-2.9ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count11ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area178.36 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity215.62 m3·mol-1ChemAxon
Polarizability87.41 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption-0.8264
Blood Brain Barrier-0.9659
Caco-2 permeable-0.5977
P-glycoprotein substrateSubstrate0.7862
P-glycoprotein inhibitor IInhibitor0.8687
P-glycoprotein inhibitor IIInhibitor0.7974
Renal organic cation transporterNon-inhibitor0.8135
CYP450 2C9 substrateNon-substrate0.9116
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.7435
CYP450 1A2 substrateNon-inhibitor0.8874
CYP450 2C9 inhibitorNon-inhibitor0.9053
CYP450 2D6 inhibitorNon-inhibitor0.9402
CYP450 2C19 inhibitorNon-inhibitor0.8969
CYP450 3A4 inhibitorNon-inhibitor0.869
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9807
Ames testNon AMES toxic0.6355
CarcinogenicityNon-carcinogens0.9422
BiodegradationNot ready biodegradable0.9698
Rat acute toxicity2.7541 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9817
hERG inhibition (predictor II)Non-inhibitor0.8733
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as macrolide lactams. These are cyclic polyketides containing both a cyclic amide and a cyclic ester group.
Kingdom
Organic compounds
Super Class
Phenylpropanoids and polyketides
Class
Macrolide lactams
Sub Class
Not Available
Direct Parent
Macrolide lactams
Alternative Parents
Alpha amino acid esters / Macrolides and analogues / Cyclohexanols / Piperidines / Oxanes / Tertiary carboxylic acid amides / Carboxylic acid esters / Cyclic alcohols and derivatives / Cyclic ketones / Hemiacetals
show 10 more
Substituents
Macrolide lactam / Alpha-amino acid ester / Macrolide / Alpha-amino acid or derivatives / Cyclohexanol / Oxane / Piperidine / Cyclic alcohol / Tertiary carboxylic acid amide / Cyclic ketone
show 24 more
Molecular Framework
Aliphatic heteropolycyclic compounds
External Descriptors
macrolide (CHEBI:61049) / Macrolides and lactone polyketides (C01375) / Macrolides and lactone polyketides (LMPK04000003)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Type i transforming growth factor beta receptor binding
Specific Function
Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevent...
Gene Name
FKBP1A
Uniprot ID
P62942
Uniprot Name
Peptidyl-prolyl cis-trans isomerase FKBP1A
Molecular Weight
11950.665 Da
References
  1. Labrande C, Velly L, Canolle B, Guillet B, Masmejean F, Nieoullon A, Pisano P: Neuroprotective effects of tacrolimus (FK506) in a model of ischemic cortical cell cultures: role of glutamate uptake and FK506 binding protein 12 kDa. Neuroscience. 2006;137(1):231-9. Epub 2005 Nov 10. [PubMed:16289353]
  2. Masri M, Rizk S, Barbari A, Stephan A, Kamel G, Rost M: An assay for the determination of sirolimus levels in the lymphocyte of transplant patients. Transplant Proc. 2007 May;39(4):1204-6. [PubMed:17524933]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  2. Ekins S, Bravi G, Wikel JH, Wrighton SA: Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates. J Pharmacol Exp Ther. 1999 Oct;291(1):424-33. [PubMed:10490933]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A5
Uniprot ID
P20815
Uniprot Name
Cytochrome P450 3A5
Molecular Weight
57108.065 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A7
Uniprot ID
P24462
Uniprot Name
Cytochrome P450 3A7
Molecular Weight
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Toxic substance binding
Specific Function
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloid...
Gene Name
ALB
Uniprot ID
P02768
Uniprot Name
Serum albumin
Molecular Weight
69365.94 Da
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Not Available
Specific Function
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in...
Gene Name
ORM1
Uniprot ID
P02763
Uniprot Name
Alpha-1-acid glycoprotein 1
Molecular Weight
23511.38 Da

Transporters

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
Inducer
General Function
Xenobiotic-transporting atpase activity
Specific Function
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name
ABCB1
Uniprot ID
P08183
Uniprot Name
Multidrug resistance protein 1
Molecular Weight
141477.255 Da
References
  1. Schuetz EG, Beck WT, Schuetz JD: Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. Mol Pharmacol. 1996 Feb;49(2):311-8. [PubMed:8632764]
  2. Saeki T, Ueda K, Tanigawara Y, Hori R, Komano T: Human P-glycoprotein transports cyclosporin A and FK506. J Biol Chem. 1993 Mar 25;268(9):6077-80. [PubMed:7681059]
  3. Wandel C, Kim RB, Kajiji S, Guengerich P, Wilkinson GR, Wood AJ: P-glycoprotein and cytochrome P-450 3A inhibition: dissociation of inhibitory potencies. Cancer Res. 1999 Aug 15;59(16):3944-8. [PubMed:10463589]
  4. Hashida T, Masuda S, Uemoto S, Saito H, Tanaka K, Inui K: Pharmacokinetic and prognostic significance of intestinal MDR1 expression in recipients of living-donor liver transplantation. Clin Pharmacol Ther. 2001 May;69(5):308-16. [PubMed:11371998]
  5. Collett A, Tanianis-Hughes J, Hallifax D, Warhurst G: Predicting P-glycoprotein effects on oral absorption: correlation of transport in Caco-2 with drug pharmacokinetics in wild-type and mdr1a(-/-) mice in vivo. Pharm Res. 2004 May;21(5):819-26. [PubMed:15180340]
  6. Quezada CA, Garrido WX, Gonzalez-Oyarzun MA, Rauch MC, Salas MR, San Martin RE, Claude AA, Yanez AJ, Slebe JC, Carcamo JG: Effect of tacrolimus on activity and expression of P-glycoprotein and ATP-binding cassette transporter A5 (ABCA5) proteins in hematoencephalic barrier cells. Biol Pharm Bull. 2008 Oct;31(10):1911-6. [PubMed:18827354]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Atpase activity, coupled to transmembrane movement of substances
Specific Function
May play a role in the processing of autolysosomes.
Gene Name
ABCA5
Uniprot ID
Q8WWZ7
Uniprot Name
ATP-binding cassette sub-family A member 5
Molecular Weight
186505.825 Da
References
  1. Quezada CA, Garrido WX, Gonzalez-Oyarzun MA, Rauch MC, Salas MR, San Martin RE, Claude AA, Yanez AJ, Slebe JC, Carcamo JG: Effect of tacrolimus on activity and expression of P-glycoprotein and ATP-binding cassette transporter A5 (ABCA5) proteins in hematoencephalic barrier cells. Biol Pharm Bull. 2008 Oct;31(10):1911-6. [PubMed:18827354]

Drug created on June 13, 2005 07:24 / Updated on October 02, 2017 04:47