Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo. It was discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. Tacrolimus is chemically known as a macrolide. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex inhibits calcineurin which inhibits T-lymphocyte signal transduction and IL-2 transcription.

Structure

Similar Structures

Synonyms

Anhydrous tacrolimus
Tacrolimus
Tacrolimus anhydrous
Tacrolimus, anhydrous

External IDs

FK-506 / FK5 / K506

Product Ingredients

Ingredient	UNII	CAS	InChI Key
Tacrolimus hydrate	WM0HAQ4WNM	109581-93-3	NWJQLQGQZSIBAF-MSLXHMNKSA-N

Product Images

Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
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Advagraf	Capsule, extended release	1 mg	Oral	Astellas Pharma Europe Bv	2007-04-23	Not applicable
Advagraf	Capsule, extended release	1 mg	Oral	Astellas Pharma Europe Bv	2007-04-23	Not applicable
Advagraf	Capsule, extended release	0.5 mg	Oral	Astellas Pharma Europe Bv	2007-04-23	Not applicable
Advagraf	Capsule, extended release	5 mg	Oral	Astellas Pharma Europe Bv	2007-04-23	Not applicable
Advagraf	Capsule, extended release		Oral	Astellas Pharma Inc	2008-04-09	Not applicable
Advagraf	Capsule, extended release	5 mg	Oral	Astellas Pharma Europe Bv	2007-04-23	Not applicable
Advagraf	Capsule, extended release	1 mg	Oral	Astellas Pharma Europe Bv	2007-04-23	Not applicable
Advagraf	Capsule, extended release	1 mg	Oral	Astellas Pharma Europe Bv	2007-04-23	Not applicable
Advagraf	Capsule, extended release	0.5 mg	Oral	Astellas Pharma Europe Bv	2007-04-23	Not applicable
Advagraf	Capsule, extended release	0.5 mg	Oral	Astellas Pharma Europe Bv	2007-04-23	Not applicable

Additional Data Available

Application Number

A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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Product Code

A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Generic Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
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Ach-tacrolimus	Capsule		Oral	Accord Healthcare Inc	Not applicable	Not applicable
Ach-tacrolimus	Capsule		Oral	Accord Healthcare Inc	Not applicable	Not applicable
Ach-tacrolimus	Capsule		Oral	Accord Healthcare Inc	Not applicable	Not applicable
Apo-tacrolimus	Capsule		Oral	Apotex Corporation	Not applicable	Not applicable
Apo-tacrolimus	Capsule		Oral	Apotex Corporation	Not applicable	Not applicable
Apo-tacrolimus	Capsule		Oral	Apotex Corporation	Not applicable	Not applicable
Apo-tacrolimus	Capsule		Oral	Apotex Corporation	Not applicable	Not applicable
Apo-tacrolimus	Capsule		Oral	Apotex Corporation	Not applicable	Not applicable
Hecoria	Capsule	5 mg/1	Oral	Novartis	2011-12-20	2015-12-31
Hecoria	Capsule	1 mg/1	Oral	Novartis	2011-12-20	2015-12-31

Additional Data Available

Application Number

A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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Product Code

A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
Hyaluronic Acid Sodium Salt 1% / Niacinamide 4% / Tacrolimus 0.1%	Tacrolimus hydrate (0.1 g/100g) + Hyaluronic acid (1 g/100g) + Nicotinamide (4 g/100g)	Cream	Topical	Sinceru Florida, LLC	2019-05-01	Not applicable
Hyaluronic Acid Sodium Salt 1% / Tacrolimus 0.1% / Urea 20%	Tacrolimus hydrate (0.1 g/100g) + Sodium hyaluronate (1 g/100g) + Urea (20 g/100g)	Cream	Topical	Sincerus Florida, LLC	2019-05-17	Not applicable
Niacinamide 4% / Tacrolimus 0.03%	Tacrolimus hydrate (0.03 g/100g) + Nicotinamide (4 g/100g)	Ointment	Topical	Sincerus Florida, LLC	2019-05-17	Not applicable
Niacinamide 4% / Tacrolimus 0.1%	Tacrolimus hydrate (0.1 g/100g) + Nicotinamide (4 g/100g)	Ointment	Topical	Sincerus Florida, LLC	2019-05-01	Not applicable
Tacrolimus 0.1%	Tacrolimus hydrate (0.1 g/100g)	Solution	Topical	Sincerus Florida, LLC	2019-05-10	Not applicable
Tacrolimus 0.1% In Pseudocatalase	Tacrolimus hydrate (0.1 g/100g)	Cream	Topical	Sincerus Florida, LLC	2019-05-01	Not applicable
Validerm	Tacrolimus hydrate (0.05 g/0.05g) + Calcitriol (0.2 mg/0.2mg) + Fluticasone propionate (0.05 g/0.05g)	Kit	Topical	Accumix Pharmaceuticals	2014-12-15	2015-07-17

Categories

UNII

Y5L2157C4J

CAS number

104987-11-3

Weight

Average: 804.0182
Monoisotopic: 803.481976677

Chemical Formula

C₄₄H₆₉NO₁₂

InChI Key

QJJXYPPXXYFBGM-LFZNUXCKSA-N

InChI

InChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19+,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1

IUPAC Name

(1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-(prop-2-en-1-yl)-11,28-dioxa-4-azatricyclo[22.3.1.0⁴,⁹]octacos-18-ene-2,3,10,16-tetrone

SMILES

CO[C@@H]1C[C@@H](CC[C@H]1O)\C=C(/C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@H](C[C@@H](C)C\C(C)=C\[C@@H](CC=C)C(=O)C[C@H](O)[C@H]1C)OC

Pharmacology

Indication

For use after allogenic organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It was given FDA approval in 1994 for use in liver transplantation. Since then, this indication has expanded to kidney, heart, small bowel, pancreas, lung, trachea, skin, cornea, and limb transplants. It has also been used in a topical preparation in the treatment of severe atopic dermatitis.

Associated Conditions

Pharmacodynamics

Tacrolimus acts by reducing peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This inhibits both T-lymphocyte signal transduction and IL-2 transcription. Tacrolimus has similar activity to cyclosporine but rates of rejection are lower with tacrolimus. Tacrolimus has also been shown to be effective in the topical treatment of eczema, particularly atopic eczema. It suppresses inflammation in a similar way to steroids, but is not as powerful. An important dermatological advantage of tacrolimus is that it can be used directly on the face; topical steroids cannot be used on the face, as they thin the skin dramatically there. On other parts of the body, topical steroid are generally a better treatment.

Mechanism of action

The mechanism of action of tacrolimus in atopic dermatitis is not known. While the following have been observed, the clinical significance of these observations in atopic dermatitis is not known. It has been demonstrated that tacrolimus inhibits T-lymphocyte activation by first binding to an intracellular protein, FKBP-12. A complex of tacrolimus-FKBP-12, calcium, calmodulin, and calcineurin is then formed and the phosphatase activity of calcineurin is inhibited. This prevents the dephosphorylation and translocation of nuclear factor of activated T-cells (NF-AT), a nuclear component thought to initiate gene transcription for the formation of lymphokines. Tacrolimus also inhibits the transcription for genes which encode IL-3, IL-4, IL-5, GM-CSF, and TNF-, all of which are involved in the early stages of T-cell activation. Additionally, tacrolimus has been shown to inhibit the release of pre-formed mediators from skin mast cells and basophils, and to downregulate the expression of FceRI on Langerhans cells.

Target	Actions	Organism
APeptidyl-prolyl cis-trans isomerase FKBP1A	inhibitor	Humans

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Absorption

Absorption of tacrolimus from the gastrointestinal tract after oral administration is incomplete and variable. The absolute bioavailability in adult kidney transplant patients is 17±10%; in adults liver transplant patients is 22±6%; in healthy subjects is 18±5%. The absolute bioavailability in pediatric liver transplant patients was 31±24%. Tacrolimus maximum blood concentrations (Cmax) and area under the curve (AUC) appeared to increase in a dose-proportional fashion in 18 fasted healthy volunteers receiving a single oral dose of 3, 7, and 10 mg. When given without food, the rate and extent of absorption were the greatest. The time of the meal also affected bioavailability. When given immediately after a meal, mean Cmax was reduced 71%, and mean AUC was reduced 39%, relative to the fasted condition. When administered 1.5 hours following the meal, mean Cmax was reduced 63%, and mean AUC was reduced 39%, relative to the fasted condition.

Volume of distribution

2.6 ± 2.1 L/kg [pediatric liver transplant patients]
1.07 ± 0.20 L/kg [patients with renal impairment, 0.02 mg/kg/4 hr dose, IV]
3.1 ± 1.6 L/kg [Mild Hepatic Impairment, 0.02 mg/kg/4 hr dose, IV]
3.7 ± 4.7 L/kg [Mild Hepatic Impairment, 7.7 mg dose, PO]
3.9 ± 1.0 L/kg [Severe hepatic impairment, 0.02 mg/kg/4 hr dose, IV]
3.1 ± 3.4 L/kg [Severe hepatic impairment, 8 mg dose, PO]

Protein binding

~99% bound to human plasma protein, primarily to albumin and alpha-1-acid glycoprotein. This is independent of concentration over a range of 5-50 ng/mL.

Metabolism

The metabolism of tacrolimus is predominantly mediated by CYP3A4 and secondarily by CYP3A5.^6,7 Tacrolimus is metabolized into 8 metabolites: 13-demethyl tacrolimus, 31-demethyl tacrolimus, 15-demethyl tacrolimus, 12-hydroxy tacrolimus, 15,31-didemethyl tacrolimus, 13,31-didemethyl tacrolimus, 13,15-didemethyl tacrolimus, and a final metabolite involving O-demethylation and the formation of a fused ring.⁶ The major metabolite identified in incubations with human liver microsomes is 13-demethyl tacrolimus.⁷ In in vitro studies, a 31-demethyl metabolite has been reported to have the same activity as tacrolimus.⁷

Route of elimination

In man, less than 1% of the dose administered is excreted unchanged in urine. When administered IV, fecal elimination accounted for 92.6±30.7%, urinary elimination accounted for 2.3±1.1%.

Half life

The elimination half life in adult healthy volunteers, kidney transplant patients, liver transplants patients, and heart transplant patients are approximately 35, 19, 12, 24 hours, respectively. The elimination half life in pediatric liver transplant patients was 11.5±3.8 hours, in pediatric kidney transplant patients was 10.2±5.0 (range 3.4-25) hours.

Clearance

0.040 L/hr/kg [healthy subjects, IV]
0.172 ± 0.088 L/hr/kg [healthy subjects, oral]
0.083 L/hr/kg [adult kidney transplant patients, IV]
0.053 L/hr/kg [adult liver transplant patients, IV]
0.051 L/hr/kg [adult heart transplant patients, IV]
0.138 ± 0.071 L/hr/kg [pediatric liver transplant patients]
0.12 ± 0.04 (range 0.06-0.17) L/hr/kg [pediatric kidney transplant patients]
0.038 ± 0.014 L/hr/kg [patients with renal impairment, 0.02 mg/kg/4 hr dose, IV]
0.042 ± 0.02 L/hr/kg [Mild Hepatic Impairment, 0.02 mg/kg/4 hr dose, IV]
0.034 ± 0.019 L/hr/kg [Mild Hepatic Impairment, 7.7 mg dose, PO]
0.017 ± 0.013 L/hr/kg [Severe hepatic impairment, 0.02 mg/kg/4 hr dose, IV]
0.016 ± 0.011 L/hr/kg [Severe hepatic impairment, 8 mg dose, PO]

Toxicity

Side effects can be severe and include blurred vision, liver and kidney problems (it is nephrotoxic), seizures, tremors, hypertension, hypomagnesemia, diabetes mellitus, hyperkalemia, itching, insomnia, confusion. LD₅₀=134-194 mg/kg (rat).

Affected organisms

Humans and other mammals

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Interacting Gene/Enzyme	Allele name	Genotype(s)	Defining Change(s)	Type(s)	Description	Details
Multidrug resistance protein 1	---	(G;T) / (T;T)	T Allele (G2677T)	ADR Directly Studied	The presence of this genotype in ABCB1 may indicate an increased risk of drug-induced neurotoxicity when treated with tacrolimus.	Details
Cytochrome P450 3A5	CYP3A5*1	Not Available	Functional gene	Effect Directly Studied	Patients with this genotype in CYP3A5 are extensive metabolizers and require higer doses of tacrolimus to attain the therapeutic effect.	Details

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Drug	Interaction
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(R)-warfarin	The serum concentration of (R)-warfarin can be increased when it is combined with Tacrolimus.
(S)-Warfarin	The serum concentration of (S)-Warfarin can be increased when it is combined with Tacrolimus.
2-Methoxyethanol	Tacrolimus may increase the immunosuppressive activities of 2-Methoxyethanol.
2,4-thiazolidinedione	The therapeutic efficacy of 2,4-thiazolidinedione can be decreased when used in combination with Tacrolimus.
4-hydroxycoumarin	The metabolism of 4-hydroxycoumarin can be decreased when combined with Tacrolimus.
6-Deoxyerythronolide B	The serum concentration of Tacrolimus can be increased when it is combined with 6-Deoxyerythronolide B.
7-ethyl-10-hydroxycamptothecin	The serum concentration of Tacrolimus can be increased when it is combined with 7-ethyl-10-hydroxycamptothecin.
9-(N-methyl-L-isoleucine)-cyclosporin A	Tacrolimus may increase the immunosuppressive activities of 9-(N-methyl-L-isoleucine)-cyclosporin A.
9-aminocamptothecin	The metabolism of Tacrolimus can be decreased when combined with 9-aminocamptothecin.
Abacavir	Tacrolimus may decrease the excretion rate of Abacavir which could result in a higher serum level.

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Food Interactions

Take on an empty stomach. Co-administration with food decreases the rate and extent of absorption.

References

Synthesis Reference

Pan Sup Chang, Hoon Cho, "Water soluble polymer-tacrolimus conjugated compounds and process for preparing the same." U.S. Patent US5922729, issued April, 1997.

US5922729

General References

Kino T, Hatanaka H, Hashimoto M, Nishiyama M, Goto T, Okuhara M, Kohsaka M, Aoki H, Imanaka H: FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics. J Antibiot (Tokyo). 1987 Sep;40(9):1249-55. [PubMed:2445721]
Pritchard DI: Sourcing a chemical succession for cyclosporin from parasites and human pathogens. Drug Discov Today. 2005 May 15;10(10):688-91. [PubMed:15896681]
Liu J, Farmer JD Jr, Lane WS, Friedman J, Weissman I, Schreiber SL: Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. 1991 Aug 23;66(4):807-15. [PubMed:1715244]
Fukatsu S, Fukudo M, Masuda S, Yano I, Katsura T, Ogura Y, Oike F, Takada Y, Inui K: Delayed effect of grapefruit juice on pharmacokinetics and pharmacodynamics of tacrolimus in a living-donor liver transplant recipient. Drug Metab Pharmacokinet. 2006 Apr;21(2):122-5. [PubMed:16702731]
Hanifin JM, Paller AS, Eichenfield L, Clark RA, Korman N, Weinstein G, Caro I, Jaracz E, Rico MJ: Efficacy and safety of tacrolimus ointment treatment for up to 4 years in patients with atopic dermatitis. J Am Acad Dermatol. 2005 Aug;53(2 Suppl 2):S186-94. [PubMed:16021174]
Iwasaki K: Metabolism of tacrolimus (FK506) and recent topics in clinical pharmacokinetics. Drug Metab Pharmacokinet. 2007 Oct;22(5):328-35. [PubMed:17965516]
FDA Approved Drug Products: Tacrolimus Oral Capsules [Link]

External Links

Human Metabolome Database: HMDB15002
KEGG Drug: D00107
KEGG Compound: C01375
PubChem Compound: 445643
PubChem Substance: 46506004
ChemSpider: 393220
BindingDB: 50030448
RxNav: 235991
ChEBI: 61049
ChEMBL: CHEMBL269732
ZINC: ZINC000169289411
Therapeutic Targets Database: DAP000162
PharmGKB: PA451578
PDBe Ligand: FK5
RxList: RxList Drug Page
Drugs.com: Drugs.com Drug Page
Wikipedia: Tacrolimus

ATC Codes

D11AH01 — Tacrolimus

L04AD02 — Tacrolimus

AHFS Codes

92:44.00 — Immunosuppressive Agents
84:92.00 — Misc. Skin and Mucous Membrane Agents

PDB Entries

1bkf / 1fkf / 1fkj / 1q6i / 1tco / 1yat / 2fke / 2vn1 / 3ihz / 3o5r …

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FDA label

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MSDS

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Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
0	Completed	Treatment	Organ Transplant Rejection / Psoriasis	1
0	Completed	Treatment	Transplantation, Stem Cell	1
0	Enrolling by Invitation	Other	Kidney Transplant Rejection / Medication Adherence	1
0	Recruiting	Treatment	Agnogenic Myeloid Metaplasia / Hematopoietic Cell Transplantation Recipient / Primary Myelofibrosis / Secondary Myelofibrosis	1
0	Recruiting	Treatment	Kidney Transplant; Complications	1
0	Terminated	Treatment	Acute Kidney Injury (AKI) / Renal Transplant Recipient Patients	1
0	Terminated	Treatment	Allogeneic peripheral haematopoietic stem cell transplant / Neuroepithelial Tumor / Tumors, Solid	1
0	Terminated	Treatment	Kidney Transplant Rejection	1
0	Withdrawn	Treatment	Multiple Myeloma (MM)	1
1	Active Not Recruiting	Treatment	Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Acute Biphenotypic Leukemia (ABL) / Acute Lymphoblastic Leukaemia Recurrent / Acute Lymphoblastic Leukemia in Remission / Acute myeloid leukaemia (in remission) / Acute, recurrent Myeloid Leukemia / Chronic Lymphocytic Leukaemia (CLL) / Chronic Lymphocytic Leukemia (CLL) - Refractory / Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Chronic, recurrent Lymphocytic Leukemia / DS Stage II Plasma Cell Myeloma / DS Stage III Plasma Cell Myeloma / High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements / ISS Stage II Plasma Cell Myeloma / ISS Stage III Plasma Cell Myeloma / Leukemias / Myelodysplastic Syndrome / Recurrent Hodgkin Lymphoma / Recurrent Non-Hodgkin Lymphoma / Recurrent Small Lymphocytic Lymphoma / Refractory Acute Lymphoblastic Leukemia / Refractory Hodgkin Lymphoma / Refractory Non-Hodgkin's lymphoma / Refractory Small Lymphocytic Lymphoma / Secondary Acute Myeloid Leukemia (Secondary AML, sAML) / Therapy-Related Acute Myeloid Leukemia / Therapy-Related Myelodysplastic Syndrome	1
1	Active Not Recruiting	Treatment	Acute Lymphoblastic Leukemia in Remission / Acute myeloid leukaemia (in remission) / Adult Acute Lymphoblastic Leukemia in Complete Remission / Childhood Acute Lymphoblastic Leukemia in Complete Remission / Previously Treated Myelodysplastic Syndromes / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Recurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Acute Myeloid Leukemia	1
1	Active Not Recruiting	Treatment	Acute Lymphocytic Leukemia (ALL) / Agnogenic Myeloid Metaplasia / Chronic Lymphocytic Leukaemia (CLL) / Chronic Myeloid Leukemia (CML) / Leukemia Acute Myeloid Leukemia (AML) / Lymphoma, Hodgkins / Malignancies, Hematologic / Multiple Myeloma (MM) / Myelodysplastic Syndrome / Myeloproliferative Syndromes / Non-Hodgkin's Lymphoma (NHL)	1
1	Active Not Recruiting	Treatment	Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome / Adult Acute Lymphoblastic Leukemia in Remission / Adult Acute Myeloid Leukemia in Remission / CD45-Positive Neoplastic Cells Present / Chronic Myelomonocytic Leukemia / Previously Treated Myelodysplastic Syndromes / Refractory Anemia With Excess Blasts / Refractory Anemia With Ring Sideroblasts / Refractory Cytopenia With Multilineage Dysplasia / Refractory Cytopenia With Multilineage Dysplasia and Ring Sideroblasts	1
1	Active Not Recruiting	Treatment	Autologous Hematopoietic Stem Cell Transplant Recipient / Leukemia, Plasma Cell / Loss of Chromosome 17p / Recurrent Plasma Cell Myeloma / Refractory Multiple Myeloma / Refractory Plasma Cell Myeloma / Stage I Multiple Myeloma / Stage II Multiple Myeloma	1
1	Active Not Recruiting	Treatment	Castration-Resistant Prostate Carcinoma / Leukemia, Plasma Cell / Prostate Carcinoma Metastatic in the Bone / Recurrent Plasma Cell Myeloma / Stage IV Prostate Cancer	1
1	Completed	Not Available	Drug Drug Interaction (DDI) / Healthy Volunteers / Pharmacokinetics of ASP015K	1
1	Completed	Not Available	Healthy Volunteers	2
1	Completed	Not Available	Healthy Volunteers / Pharmacokinetics of ASP015K and Tacrolimus	1
1	Completed	Not Available	Healthy Volunteers / Pharmacokinetics of Isavuconazole / Pharmacokinetics of Tacrolimus	1
1	Completed	Basic Science	Drug Drug Interaction (DDI) / High Cholesterol / Immunosuppression / Pharmacokinetics	1
1	Completed	Basic Science	Healthy Volunteers	1
1	Completed	Basic Science	Healthy Volunteers / Pharmacokinetics / Venous Thromboembolism	1
1	Completed	Basic Science	Hepatitis C Viral Infection	1
1	Completed	Diagnostic	Bioequivalence	1
1	Completed	Other	Healthy Volunteers	1
1	Completed	Prevention	Healthy Volunteers	1
1	Completed	Supportive Care	Chronic Myeloproliferative Disorders / Graft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases	1
1	Completed	Treatment	Agnogenic Myeloid Metaplasia / Leukemias / Malignant Lymphomas / Smith-Magenis Syndrome	1
1	Completed	Treatment	Allogeneic Stem Cell Transplantation / Malignancies, Hematologic	1
1	Completed	Treatment	Alopecia	1
1	Completed	Treatment	Atopic Dermatitis (AD)	2
1	Completed	Treatment	Blood And Marrow Transplantation / Leukemias / Malignant Lymphomas / Transplantation Infection / Transplantation, Bone Marrow	1
1	Completed	Treatment	CD20 Positive / Chronic Lymphocytic Leukaemia (CLL) / Follicular Lymphoma (FL) / Leukemias / Malignant Lymphomas / Mantle Cell Lymphoma (MCL) / Marginal Zone Lymphoma (MZL) / Recurrent Diffuse Large B-Cell Lymphoma / T-Cell Non-Hodgkin Lymphoma	1
1	Completed	Treatment	Chronic Hepatitis C Virus (HCV) Infection / Immunosuppression / Transplantation, Organ	1
1	Completed	Treatment	Chronic Myeloproliferative Disorders / Graft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Precancerous/Nonmalignant Condition / Small Intestine Cancer	1
1	Completed	Treatment	Chronic Myeloproliferative Disorders / Leukemias / Malignant Lymphomas / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Neoplasms	1
1	Completed	Treatment	End-Stage Renal Disease (ESRD) / Impaired kidney function / Nephritis, Lupus / Systemic Lupus Erythematosus (SLE)	1
1	Completed	Treatment	Graft Versus Host Disease (GVHD) / Peripheral Blood Stem Cell Transplantation / Transplantation, Homologous	1
1	Completed	Treatment	Healthy Volunteers	4
1	Completed	Treatment	Hepatitis C Virus (HCV) Infection	1
1	Completed	Treatment	Immunosuppressant(Organ Transplantation, RA)	1
1	Completed	Treatment	Leukemias / Lymphoma, Hodgkins / Multiple Myeloma (MM) / Myelodysplastic Syndromes (MDS) / Non-Hodgkin's Lymphoma (NHL)	1
1	Completed	Treatment	Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes	2
1	Completed	Treatment	Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases	1
1	Completed	Treatment	Leukemias / Myelodysplastic Syndrome	2
1	Completed	Treatment	Psoriasis	1
1	Completed	Treatment	Renal Replacement Therapies	1
1	Not Yet Recruiting	Other	Transplant, Kidney	1
1	Not Yet Recruiting	Supportive Care	Allogeneic Hematopoietic Stem Cell Transplant Recipient / Hematopoietic and Lymphoid Cell Neoplasm	1
1	Not Yet Recruiting	Treatment	Vitiligo Vulgaris	1
1	Recruiting	Other	Kidney Transplant Failure and Rejection / Kidney Transplant; Complications	1
1	Recruiting	Treatment	Acute myeloid leukaemia (in remission) / Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome / Adult Acute Lymphoblastic Leukemia in Complete Remission / Aplastic Anemia / Blasts Under 10 Percent of Bone Marrow Nucleated Cells / Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Chronic Myelomonocytic Leukemia / Chronic, recurrent Lymphocytic Leukemia / Hematopoietic Cell Transplantation Recipient / Leukemias / Minimal Residual Disease / Myeloproliferative Neoplasms / Plasma Cell Myeloma / Recurrent Hodgkin Lymphoma / Recurrent Non-Hodgkin Lymphoma / Recurrent Plasma Cell Myeloma / Recurrent Small Lymphocytic Lymphoma / Therapy-Related Myelodysplastic Syndrome	1
1	Recruiting	Treatment	Acute myeloid leukaemia (in remission) / Hematopoietic Cell Transplant Recipient / Hematopoietic Cell Transplantation Recipient / Leukemia Acute Myeloid Leukemia (AML)	1
1	Recruiting	Treatment	Allogeneic Hematopoietic Stem Cell Transplant Recipient / Blasts 15 Percent or Less of Bone Marrow Nucleated Cells / Blasts 5 Percent or Less of Bone Marrow Nucleated Cells / Secondary Myelofibrosis	1
1	Recruiting	Treatment	Amputations / Genital Diseases, Male / Urologic Injuries	1
1	Recruiting	Treatment	Clinical Stage III Cutaneous Melanoma AJCC v8 / Clinical Stage III Merkel Cell Carcinoma AJCC v8 / Clinical Stage IV Cutaneous Melanoma AJCC v8 / Clinical Stage IV Merkel Cell Carcinoma AJCC v8 / High-Frequency Microsatellite Instability / Metastatic Basal cell carcinoma / Metastatic Melanoma / Metastatic Merkel Cell Carcinoma / Metastatic Skin Squamous Cell Carcinoma / Pathologic Stage III Cutaneous Melanoma AJCC v8 / Pathologic Stage III Merkel Cell Carcinoma AJCC v8 / Pathologic Stage IIIA Cutaneous Melanoma AJCC v8 / Pathologic Stage IIIA Merkel Cell Carcinoma AJCC v8 / Pathologic Stage IIIB Cutaneous Melanoma AJCC v8 / Pathologic Stage IIIB Merkel Cell Carcinoma AJCC v8 / Pathologic Stage IIIC Cutaneous Melanoma AJCC v8 / Pathologic Stage IIID Cutaneous Melanoma AJCC v8 / Pathologic Stage IV Cutaneous Melanoma AJCC v8 / Pathologic Stage IV Merkel Cell Carcinoma AJCC v8 / Renal Transplant Recipient Patients / Unresectable Basal Cell Carcinoma / Unresectable Melanoma / Unresectable Merkel Cell Carcinoma	1
1	Recruiting	Treatment	Graft Versus Host Disease (GVHD) / Sickle Cell Disorders	1
1	Recruiting	Treatment	Haemoglobinopathies congenital / Sickle Cell Anemia / Sickle Cell Disorders / Thalassaemic disorders	1
1	Recruiting	Treatment	Previously Treated Myelodysplastic Syndromes / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Recurrent Hematologic Malignancy	1
1	Recruiting	Treatment	Primary Myelofibrosis / Secondary Myelofibrosis	1
1	Terminated	Treatment	Juvenile Myelomonocytic Leukemia / Leukemia Acute Myeloid Leukemia (AML) / Myelodysplastic Syndrome	1
1	Terminated	Treatment	Leukemias / Lymphoma, Hodgkins / Multiple Myeloma (MM) / Non-Hodgkin's Lymphoma (NHL) / Smith-Magenis Syndrome	1
1	Terminated	Treatment	Transplantation, Liver	1
1	Terminated	Treatment	Vasculitis	1
1	Unknown Status	Treatment	Ocular GVHD	1
1	Unknown Status	Treatment	Transplantation, Organ	1
1	Withdrawn	Other	Transplant, Kidney	1
1	Withdrawn	Supportive Care	Acute myeloid leukaemia (in remission) / Primary Myelofibrosis / Primary Myelofibrosis, Prefibrotic Stage / Secondary Acute Myeloid Leukemia (Secondary AML, sAML) / Secondary Myelofibrosis	1
1	Withdrawn	Supportive Care	Hematopoietic and Lymphoid Cell Neoplasm / Hematopoietic Cell Transplantation Recipient	1
1	Withdrawn	Treatment	Cutaneous T-Cell Non-Hodgkin Lymphoma / Recurrent Mycosis Fungoides and Sezary Syndrome / Stage IIB Mycosis Fungoides and Sezary Syndrome / Stage IIIA Mycosis Fungoides and Sezary Syndrome / Stage IIIB Mycosis Fungoides and Sezary Syndrome / Stage IVA Mycosis Fungoides and Sezary Syndrome / Stage IVB Mycosis Fungoides and Sezary Syndrome	1
1	Withdrawn	Treatment	Invasive Aspergillosis	1
1	Withdrawn	Treatment	Leukemias / Malignant Lymphomas / Pediatric Disorders / Transplantation, Stem Cell	1
1	Withdrawn	Treatment	Scleroderma	1
1, 2	Active Not Recruiting	Treatment	Beta Thalassemia-Major / Sickle Cell Disorders	1
1, 2	Active Not Recruiting	Treatment	Chronic Myeloproliferative Disorders / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes	1
1, 2	Active Not Recruiting	Treatment	Graft Versus Host Disease (GVHD) / Leukemias / Myelodysplastic Syndromes	1
1, 2	Active Not Recruiting	Treatment	Graft Versus Host Disease (GVHD) / Malignancies, Hematologic / Relapses	1
1, 2	Completed	Basic Science	Transplantation, Kidney	1
1, 2	Completed	Prevention	Malignancies, Hematologic	1
1, 2	Completed	Supportive Care	Chronic Myeloproliferative Disorders / Graft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases	1
1, 2	Completed	Treatment	Acute Lymphoblastic Leukaemias (ALL) / Aggressive Non-Hodgkin Lymphoma / Chronic Lymphocytic Leukemia (CLL) - Refractory / Chronic, recurrent Lymphocytic Leukemia / Leukemia Acute Myeloid Leukemia (AML) / Lymphoma, Large B-Cell, Diffuse (DLBCL) / Previously Treated Myelodysplastic Syndromes / Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Recurrent Indolent Adult Non-Hodgkin Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Plasma Cell Myeloma / Recurrent Small Lymphocytic Lymphoma / Refractory Hodgkin Lymphoma / Refractory Plasma Cell Myeloma / Refractory Small Lymphocytic Lymphoma / Waldenström's Macroglobulinemia (WM)	1
1, 2	Completed	Treatment	CNI Side Effects	1
1, 2	Completed	Treatment	Complete Atypical DiGeorge Anomaly / Complete Atypical DiGeorge Syndrome / Complete DiGeorge Anomaly / Complete DiGeorge Syndrome / DiGeorge Anomaly	1
1, 2	Completed	Treatment	Graft Versus Host Disease (GVHD) / Malignancies, Hematologic	1
1, 2	Completed	Treatment	Kidney Diseases / Renal Failure / Transplantation, Kidney	1
1, 2	Completed	Treatment	Kidney Diseases / Transplant, Kidney / Transplantation, Kidney / Transplantation, Renal	1
1, 2	Completed	Treatment	Kidney Diseases / Transplantation, Kidney	1
1, 2	Completed	Treatment	Leukemia, Acute / Lymphoma, Hodgkins / Multiple Myeloma (MM) / Myelodysplastic Syndrome / Non-Hodgkin's Lymphoma (NHL)	1
1, 2	Completed	Treatment	Leukemias	1
1, 2	Completed	Treatment	Leukemias / Malignant Lymphomas	1
1, 2	Completed	Treatment	Malignancies, Hematologic	3
1, 2	Completed	Treatment	Scleroderma, Systemic / Severe Systemic Sclerosis	1
1, 2	Completed	Treatment	Type 1 Diabetes Mellitus	1
1, 2	Enrolling by Invitation	Treatment	Kidney Transplant Failure and Rejection	1
1, 2	Not Yet Recruiting	Treatment	Allogeneic Hematopoietic Stem Cell Transplant Recipient / Donor / Hematopoietic and Lymphoid Cell Neoplasm	1
1, 2	Not Yet Recruiting	Treatment	Kidney Tubular Necrosis, Acute / Transplantation, Kidney	1
1, 2	Recruiting	Prevention	Acute GvHD / Graft Versus Host Disease (GVHD)	1
1, 2	Recruiting	Prevention	Acute Lymphoblastic Leukemia in Remission / Acute myeloid leukaemia (in remission) / Chronic Myelogenous Leukemia - Chronic Phase / Chronic Myelogenous Leukemia, Accelerated Phase / Chronic Myelogenous Leukemia, Blastic Phase / Follicular Lymphoma (FL) / Graft Versus Host Disease (GVHD) / Hematologic Diseases / Lymphoma, Large B-Cell, Diffuse (DLBCL) / Mantle Cell Lymphoma (MCL) / Myelodysplastic Syndromes / Non-Hodgkin's Lymphoma (NHL)	1
1, 2	Recruiting	Prevention	Graft Versus Host Disease (GVHD) / Lung Cancers	1
1, 2	Recruiting	Treatment	Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Acute myeloid leukaemia (in remission) / Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome / Acute Myeloid Leukemia With Gene Mutations / Acute, recurrent Myeloid Leukemia / Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Chronic Myelogenous Leukemia, BCR-ABL1 Positive in Remission / De Novo Myelodysplastic Syndrome / Leukemias / Myelodysplastic Syndrome / Myeloproliferative Disorders / Previously Treated Myelodysplastic Syndromes / Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Therapy-Related Acute Myeloid Leukemia	1
1, 2	Recruiting	Treatment	Acute Lymphoblastic Leukaemia Recurrent / Acute Lymphoblastic Leukemia in Remission / Acute myeloid leukaemia (in remission) / Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome / Acute, recurrent Myeloid Leukemia / CD45-Positive Neoplastic Cells Present / Chronic Myelomonocytic Leukemia / High Risk Myelodysplastic Syndrome / Myelodysplastic Syndrome With Excess Blasts / Myeloproliferative Neoplasm, Unclassifiable / Myeloproliferative Neoplasms / Refractory Acute Lymphoblastic Leukemia / Refractory Acute Myelogenous Leukemia (AML)	1
1, 2	Recruiting	Treatment	Acute Lymphoblastic Leukaemias (ALL) / Chronic Myeloid Leukemia (CML) / Juvenile Myelomonocytic Leukemia (JMML) / Leukemia Acute Myeloid Leukemia (AML) / Lymphoma (Hodgkin's and Non-Hodgkin's) / Myelodysplastic Syndromes (MDS)	1
1, 2	Recruiting	Treatment	Adult Living Donor Kidney Transplant Recipients / Living Kidney Donors / Transplant, Kidney	1
1, 2	Recruiting	Treatment	Age-Related Macular Degeneration (ARMD)	1
1, 2	Recruiting	Treatment	Acute, recurrent Myeloid Leukemia / Allogeneic Hematopoietic Stem Cell Transplant Recipient / Allogeneic Hematopoietic Stem Cell Transplantation Recipient / Donor / Leukemia Acute Myeloid Leukemia (AML) / Malignant Neoplasms Stated as Primary Lymphoid Haematopoietic / Refractory Acute Myelogenous Leukemia (AML)	1
1, 2	Recruiting	Treatment	Hematopoietic Cell Transplantation Recipient / Malignant Lymphomas / Refractory B-Cell Non-Hodgkin Lymphoma / Refractory Hodgkin Lymphoma / Refractory T-Cell Non-Hodgkin Lymphoma	1
1, 2	Recruiting	Treatment	Hematopoietic Stem Cell Transplantation (HSCT) / Multiple Myeloma (MM)	1
1, 2	Recruiting	Treatment	Hematopoietic and Lymphoid Cell Neoplasm / Leukemias / Malignant Lymphomas	1
1, 2	Recruiting	Treatment	Malignancies, Hematologic	1
1, 2	Recruiting	Treatment	Tacrolimus / Vitiligo	1
1, 2	Terminated	Treatment	Acute Lymphoblastic Leukaemias (ALL) / Chronic Chronic myelogenous leukemia / Disorders, Lymphoproliferative / Hematologic Diseases / Leukemia Acute Myeloid Leukemia (AML) / Multiple Myeloma (MM) / Myelodysplastic and Myeloproliferative Disorders / Plasma Cell Dyscrasia	1
1, 2	Terminated	Treatment	Allogeneic Hematopoietic Stem Cell Transplantation Recipient / Chronic Lymphocytic Leukaemia (CLL) / Leukemia, Prolymphocytic / Leukemias / Richter's Syndrome	1
1, 2	Terminated	Treatment	Graft Failure	1
1, 2	Terminated	Treatment	Graft Versus Host Disease (GVHD)	1
1, 2	Terminated	Treatment	Graft Versus Host Disease (GVHD) / Leukemias / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases	1
1, 2	Terminated	Treatment	Graft Versus Host Disease (GVHD) / Lupus Erythematosus	1
1, 2	Terminated	Treatment	Inherited Metabolic Storage Diseases	1
1, 2	Terminated	Treatment	Leukemias / Myeloproliferative Disorders / Plasma Cell Myeloma	1
1, 2	Terminated	Treatment	Malignancies, Hematologic	1
1, 2	Terminated	Treatment	Multiple Myeloma (MM)	1
1, 2	Unknown Status	Treatment	Blood And Marrow Transplantation / Leukemias / Lymphoma, Hodgkins / Malignant Lymphomas / Myelodysplastic Syndromes (MDS) / Non-Hodgkin's Lymphoma (NHL) / Transplantation Infection	1
1, 2	Unknown Status	Treatment	Chronic Allograft Nephropathy (CAN) / Transplant, Kidney	1
1, 2	Unknown Status	Treatment	End Stage Renal Disease (ESRD) / Transplant, Kidney	1
1, 2	Unknown Status	Treatment	End-Stage Renal Disease (ESRD) / Renal Failure	1
1, 2	Unknown Status	Treatment	Leukemia, Acute / Myelodysplastic Syndrome / Tumors, Solid	1
1, 2	Withdrawn	Treatment	Multiple Myeloma (MM) / Refractory Multiple Myeloma	1
1, 2	Withdrawn	Treatment	Peripheral Nerve Injury (PNI)	1
2	Active Not Recruiting	Other	Heart Transplantation / Transplantation, Kidney / Transplantation, Liver	1
2	Active Not Recruiting	Prevention	Graft Versus Host Disease (GVHD)	3
2	Active Not Recruiting	Prevention	Heart Transplantation / Intestine Transplantation / Transplantation, Kidney / Transplantation, Liver / Transplantation, Lung	1
2	Active Not Recruiting	Treatment	Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Acute Biphenotypic Leukemia (ABL) / Acute Leukemias of Ambiguous Lineage / Acute myeloid leukaemia (in remission) / Acute Undifferentiated Leukemia (AUL) / Adult Acute Lymphoblastic Leukemia in Remission / Adult Acute Myeloid Leukemia in Remission / Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Childhood Acute Lymphoblastic Leukemia in Remission / Childhood Acute Myeloid Leukemia in Remission / Childhood Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Myelodysplastic Syndrome With Excess Blasts-1 / Myelodysplastic Syndrome With Excess Blasts-2 / RAEB-1 / RAEB-2 / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Recurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Acute Myeloid Leukemia / Refractory Adult Acute Lymphoblastic Leukemia / Refractory Anemia With Excess Blasts / Refractory Childhood Acute Lymphoblastic Leukemia	1
2	Active Not Recruiting	Treatment	Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Acute Biphenotypic Leukemia (ABL) / Acute Lymphoblastic Leukaemias (ALL) / Acute Lymphoblastic Leukemia in Remission / Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome / Chemotherapy-Related Leukemia / Chronic Lymphocytic Leukaemia (CLL) / Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Chronic Myelomonocytic Leukemia / Hematopoietic/Lymphoid Cancer / Langerhans Cell Histiocytosis (LCH) / Leukemia Acute Myeloid Leukemia (AML) / Leukemia, Acute / Lymphoma, Hodgkins / Minimal Residual Disease / Myelodysplastic Syndrome / Myelodysplastic Syndrome With Excess Blasts / Non-Hodgkin's Lymphoma (NHL) / Recurrent Hodgkin Lymphoma / Refractory Acute Lymphoblastic Leukemia / Refractory Myelodysplastic Syndrome / Small Lymphocytic Lymphoma / Therapy-Related Myelodysplastic Syndrome	1
2	Active Not Recruiting	Treatment	Acute Lymphoblastic Leukaemias (ALL) / Adult Acute Lymphoblastic Leukemia in Remission / Adult B Acute Lymphoblastic Leukemia / Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 / Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1 / Adult L1 Acute Lymphoblastic Leukemia / Adult L2 Acute Lymphoblastic Leukemia / Adult T Acute Lymphoblastic Leukemia / Recurrent Adult Acute Lymphoblastic Leukemia / Untreated Adult Acute Lymphoblastic Leukemia	1
2	Active Not Recruiting	Treatment	Acute Lymphoblastic Leukaemias (ALL) / Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 / Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1 / Untreated Adult Acute Lymphoblastic Leukemia	1
2	Active Not Recruiting	Treatment	Acute Lymphocytic Leukemia (ALL) / Chronic Lymphocytic Leukaemia (CLL) / Chronic Myeloid Leukemia (CML) / Leukemia Acute Myeloid Leukemia (AML) / Leukemias / Lymphoma, Hodgkins / Multiple Myeloma (MM) / Myelodysplastic Syndrome / Myeloproliferative Disorders / Non-Hodgkin's Lymphoma (NHL)	1
2	Active Not Recruiting	Treatment	Acute Lymphocytic Leukemia (ALL) / Leukemia Acute Myeloid Leukemia (AML) / Myelodysplastic Syndrome RAEB 1 / Myelodysplastic Syndrome RAEB 2	1
2	Active Not Recruiting	Treatment	Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome / Adult Acute Lymphoblastic Leukemia in Remission / Adult Acute Megakaryoblastic Leukemia (M7) / Adult Acute Minimally Differentiated Myeloid Leukemia (M0) / Adult Acute Monoblastic Leukemia (M5a) / Adult Acute Monocytic Leukemia (M5b) / Adult Acute Myeloblastic Leukemia With Maturation (M2) / Adult Acute Myeloblastic Leukemia Without Maturation (M1) / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Adult Acute Myelomonocytic Leukemia (M4) / Adult Erythroleukemia (M6a) / Adult Pure Erythroid Leukemia (M6b) / Chronic Myelomonocytic Leukemia / Myelodysplastic Syndrome / Previously Treated Myelodysplastic Syndromes / Secondary Acute Myeloid Leukemia (Secondary AML, sAML) / Secondary Acute Myeloid Leukemia in Remission / Secondary Myelodysplastic Syndromes / Therapy-Related Myelodysplastic Syndrome	1
2	Active Not Recruiting	Treatment	Adult Acute Megakaryoblastic Leukemia / Adult Acute Monoblastic Leukemia / Adult Acute Monocytic Leukemia / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11 / Adult Acute Myeloid Leukemia With Maturation / Adult Acute Myeloid Leukemia With Minimal Differentiation / Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11 / Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); RUNX1-RUNX1T1 / Adult Acute Myeloid Leukemia With t(8;21); (q22; q22.1); RUNX1-RUNX1T1 / Adult Acute Myeloid Leukemia With t(9;11)(p21.3;q23.3); MLLT3-KMT2A / Adult Acute Myeloid Leukemia With t(9;11)(p22.3;q23.3); MLLT3-KMT2A / Adult Acute Myeloid Leukemia With t(9;11)(p22;q23); MLLT3-MLL / Adult Acute Myeloid Leukemia Without Maturation / Adult Acute Myelomonocytic Leukemia / Adult Erythroleukemia / Adult Pure Erythroid Leukemia / Alkylating Agent-Related Acute Myeloid Leukemia / De Novo Myelodysplastic Syndrome / Leukemia Acute Myeloid Leukemia (AML) / Myelodysplastic Syndrome / Myelodysplastic Syndrome With Excess Blasts / Previously Treated Myelodysplastic Syndromes / Recurrent Adult Acute Myeloid Leukemia / Refractory Anemia With Excess Blasts / Secondary Myelodysplastic Syndromes / Untreated Adult Acute Myeloid Leukemia	1
2	Active Not Recruiting	Treatment	Agnogenic Myeloid Metaplasia / Chronic Lymphocytic Leukaemia (CLL) / Chronic Myeloid Leukemia (CML) / Chronic Myelomonocytic Leukemia / Chronic Myeloproliferative Disorders / Essential Thrombocythemia (ET) / Leukemia, Plasma Cell / Leukemia, Prolymphocytic / Multiple Myeloma (MM) / Myelodysplastic Syndrome / Myelodysplastic Syndromes / Plasma Cell Dyscrasia / Plasma Cell Neoplasms / Polycythemia Vera (PV) / Small Lymphocytic Lymphoma	1
2	Active Not Recruiting	Treatment	Aplastic Anemia / Donor / Immunodeficiency Syndrome / Non-Cancer Diagnosis / Severe Aplastic Anemia (SAA)	1
2	Active Not Recruiting	Treatment	Bone Marrow Failure Syndromes / Severe Aplastic Anemia (SAA)	1
2	Active Not Recruiting	Treatment	Chronic Lymphocytic Leukaemia (CLL) / Chronic Myelomonocytic Leukemia / Leukemia Acute Myeloid Leukemia (AML) / Lymphoma, B-Cell / Lymphoma, Hodgkins / Myelodysplastic Syndromes / Myeloproliferative Disorders / Non-Hodgkin's Lymphoma (NHL) / T-Cell Lymphomas	1
2	Active Not Recruiting	Treatment	Chronic Lymphocytic Leukaemia (CLL) / Lymphoma, Hodgkins / Lymphoma, Large B-Cell, Diffuse (DLBCL) / Lymphoma, Low-Grade / Mantle Cell Lymphoma (MCL) / Small Lymphocytic Lymphoma / T-Cell Lymphomas	1
2	Active Not Recruiting	Treatment	Chronic Myeloproliferative Disorders / Graft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases / Precancerous/Nonmalignant Condition	1
2	Active Not Recruiting	Treatment	Chronic Myeloproliferative Disorders / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes	1
2	Active Not Recruiting	Treatment	Compliance, Patient / Graft Failure / Heart Transplant Rejection	1
2	Active Not Recruiting	Treatment	Crohn's Disease (CD)	1
2	Active Not Recruiting	Treatment	Graft Survival / HLA-mismatched Bone Marrow Transplantation / Myeloablative Conditioning / Transplantation, Bone Marrow / Transplantion, Bone Marrow	1
2	Active Not Recruiting	Treatment	Graft Versus Host Disease (GVHD)	1
2	Active Not Recruiting	Treatment	Graft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas	1
2	Active Not Recruiting	Treatment	Graft Versus Host Disease (GVHD) / Leukemias / Myelodysplastic Syndromes	1
2	Active Not Recruiting	Treatment	Leukemias	2
2	Active Not Recruiting	Treatment	Leukemias / Malignant Lymphomas	2
2	Active Not Recruiting	Treatment	Non-Hodgkin's Lymphoma (NHL)	1
2	Completed	Not Available	Atopic Dermatitis (AD)	1
2	Completed	Prevention	Acute Graft Versus Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation / Hematopoietic Stem Cell Transplantation (HSCT)	1
2	Completed	Prevention	Acute Lymphoblastic Leukaemias (ALL) / Chronic Chronic myelogenous leukemia / Graft Versus Host Disease (GVHD) / Hodgkins Disease (HD) / Leukemia Acute Myeloid Leukemia (AML) / Myelodysplastic Syndromes / Non-Hodgkin's Lymphoma (NHL)	1
2	Completed	Prevention	Acute Lymphoblastic Leukaemias (ALL) / Hodgkins Disease (HD) / Malignancies, Hematologic / Myelodysplastic Syndrome / Myelogenous Leukemia / Non-Hodgkin's Lymphoma (NHL)	1
2	Completed	Prevention	Chronic Lung Diseases	1
2	Completed	Prevention	Chronic Chronic myelogenous leukemia / Chronic Lymphocytic Leukaemia (CLL) / Follicular Lymphoma (FL) / Leukemia, Acute / Lymphoma, B-Cell / Lymphoma, Hodgkins / Lymphoma, Large B-Cell, Diffuse (DLBCL) / Myelodysplasia / Small Lymphocytic Lymphoma	1
2	Completed	Prevention	Chronic Renal Failure (CRF) / Immunosuppression / Transplantation, Kidney	1
2	Completed	Prevention	De Novo Kidney Transplantation	1
2	Completed	Prevention	Graft Versus Host Disease (GVHD) / Neoplasms, Hematologic / Non-Neoplastic Hematologic and Lymphocytic Disorder	1
2	Completed	Prevention	Graft Versus Host Disease, Acute	1
2	Completed	Prevention	Heart Transplantation / Pancreas (Including SPK) Transplantation / Transplantation, Lung	1
2	Completed	Prevention	Hepatitis C Viral Infection / Transplantation, Liver	1
2	Completed	Prevention	Highly-sensitized Kidney Transplant Recipients	1
2	Completed	Prevention	Liver Dysfunction / Rejection, Transplant / Transplantation, Liver	1
2	Completed	Prevention	Transplantation, Kidney	3
2	Completed	Prevention	Transplantation, Liver	3
2	Completed	Prevention	Transplantation, Renal	1
2	Completed	Prevention	Type 1 Diabetes Mellitus	1
2	Completed	Supportive Care	Accelerated Phase Chronic Myelogenous Leukemia / Adult Acute Lymphoblastic Leukemia in Remission / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Atypical Chronic Myeloid Leukemia / Blastic Phase Chronic Myelogenous Leukemia / Childhood Acute Lymphoblastic Leukemia in Remission / Childhood Acute Myeloid Leukemia in Remission / Childhood Chronic Myelogenous Leukemia / Childhood Myelodysplastic Syndromes / Chronic Eosinophilic Leukemia (CEL) / Chronic Lymphocytic Leukemia (CLL) - Refractory / Chronic Myelomonocytic Leukemia / Chronic Neutrophilic Leukemia / Chronic Phase Chronic Myelogenous Leukemia / Contiguous Stage II Adult Burkitt Lymphoma / Contiguous Stage II Adult Diffuse Large Cell Lymphoma / Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma / Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma / Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma / Contiguous Stage II Adult Lymphoblastic Lymphoma / Contiguous Stage II Grade 1 Follicular Lymphoma / Contiguous Stage II Grade 2 Follicular Lymphoma / Contiguous Stage II Grade 3 Follicular Lymphoma / Contiguous Stage II Mantle Cell Lymphoma / Contiguous Stage II Marginal Zone Lymphoma / Contiguous Stage II Small Lymphocytic Lymphoma / De Novo Myelodysplastic Syndromes / Essential Thrombocythemia (ET) / Extramedullary Plasmacytoma / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Graft Versus Host Disease (GVHD) / Hematopoietic/Lymphoid Cancer / Isolated Plasmacytoma of Bone / Juvenile Myelomonocytic Leukemia / Meningeal Chronic Myelogenous Leukemia / Myelodysplastic/Myeloproliferative Disease, Unclassifiable / Nodal marginal zone B-cell lymphomas / Noncontiguous Stage II Adult Burkitt Lymphoma / Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma / Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma / Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma / Noncontiguous Stage II Adult Lymphoblastic Lymphoma / Noncontiguous Stage II Grade 1 Follicular Lymphoma / Noncontiguous Stage II Grade 2 Follicular Lymphoma / Noncontiguous Stage II Grade 3 Follicular Lymphoma / Noncontiguous Stage II Mantle Cell Lymphoma / Noncontiguous Stage II Marginal Zone Lymphoma / Noncontiguous Stage II Small Lymphocytic Lymphoma / Previously Treated Myelodysplastic Syndromes / Primary Myelofibrosis / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Grade III Lymphomatoid Granulomatosis / Recurrent Adult Hodgkin's Lymphoma / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Adult T-Cell Leukemia/Lymphoma / Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Mycosis Fungoides/Sezary Syndrome / Recurrent Small Lymphocytic Lymphoma / Recurrent/Refractory Childhood Hodgkin Lymphoma / Refractory Hairy Cell Leukemia / Relapsing Chronic Myelogenous Leukemia / Secondary Myelodysplastic Syndromes / Stage I Adult Burkitt Lymphoma / Stage I Adult Diffuse Large Cell Lymphoma / Stage I Adult Diffuse Mixed Cell Lymphoma / Stage I Adult Diffuse Small Cleaved Cell Lymphoma / Stage I Adult Hodgkin Lymphoma / Stage I Adult Immunoblastic Large Cell Lymphoma / Stage I Adult Lymphoblastic Lymphoma / Stage I Adult T-Cell Leukemia/Lymphoma / Stage I Childhood Hodgkin Lymphoma / Stage I Chronic Lymphocytic Leukemia / Stage I Cutaneous T-cell Non-Hodgkin Lymphoma / Stage I Grade 1 Follicular Lymphoma / Stage I Grade 2 Follicular Lymphoma / Stage I Grade 3 Follicular Lymphoma / Stage I Mantle Cell Lymphoma / Stage I Marginal Zone Lymphoma / Stage I Multiple Myeloma / Stage I Mycosis Fungoides/Sezary Syndrome / Stage I Small Lymphocytic Lymphoma / Stage II Adult Hodgkin Lymphoma / Stage II Adult T-Cell Leukemia/Lymphoma / Stage II Chronic Lymphocytic Leukemia / Stage II Cutaneous T-cell Non-Hodgkin Lymphoma / Stage II Multiple Myeloma / Stage II Mycosis Fungoides/Sezary Syndrome / Stage III Adult Burkitt Lymphoma / Stage III Adult Diffuse Large Cell Lymphoma / Stage III Adult Diffuse Mixed Cell Lymphoma / Stage III Adult Diffuse Small Cleaved Cell Lymphoma / Stage III Adult Hodgkin Lymphoma / Stage III Adult Immunoblastic Large Cell Lymphoma / Stage III Adult Lymphoblastic Lymphoma / Stage III Adult T-Cell Leukemia/Lymphoma / Stage III Chronic Lymphocytic Leukemia / Stage III Cutaneous T-Cell Non-Hodgkin Lymphoma / Stage III Grade 1 Follicular Lymphoma / Stage III Grade 2 Follicular Lymphoma / Stage III Grade 3 Follicular Lymphoma / Stage III Mantle Cell Lymphoma / Stage III Marginal Zone Lymphoma / Stage III Multiple Myeloma / Stage III Mycosis Fungoides/Sezary Syndrome / Stage III Small Lymphocytic Lymphoma / Stage IV Adult Burkitt Lymphoma / Stage IV Adult Diffuse Large Cell Lymphoma / Stage IV Adult Diffuse Mixed Cell Lymphoma / Stage IV Adult Diffuse Small Cleaved Cell Lymphoma / Stage IV Adult Hodgkin Lymphoma / Stage IV Adult Immunoblastic Large Cell Lymphoma / Stage IV Adult Lymphoblastic Lymphoma / Stage IV Adult T-Cell Leukemia/Lymphoma / Stage IV Chronic Lymphocytic Leukemia / Stage IV Cutaneous T-Cell Non-Hodgkin Lymphoma / Stage IV Grade 1 Follicular Lymphoma / Stage IV Grade 2 Follicular Lymphoma / Stage IV Grade 3 Follicular Lymphoma / Stage IV Marginal Zone Lymphoma / Stage IV Mycosis Fungoides/Sezary Syndrome / Stage IV Small Lymphocytic Lymphoma	1
2	Completed	Supportive Care	Accelerated Phase Chronic Myelogenous Leukemia / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Adult Grade III Lymphomatoid Granulomatosis / B-Cell Chronic Lymphocytic Leukemia / Chronic Lymphocytic Leukemia (CLL) - Refractory / Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Chronic Myelomonocytic Leukemia / Chronic Phase Chronic Myelogenous Leukemia / Contiguous Stage II Adult Burkitt Lymphoma / Contiguous Stage II Adult Diffuse Large Cell Lymphoma / Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma / Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma / Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma / Contiguous Stage II Adult Lymphoblastic Lymphoma / Contiguous Stage II Grade 1 Follicular Lymphoma / Contiguous Stage II Grade 2 Follicular Lymphoma / Contiguous Stage II Grade 3 Follicular Lymphoma / Contiguous Stage II Mantle Cell Lymphoma / Contiguous Stage II Marginal Zone Lymphoma / Contiguous Stage II Small Lymphocytic Lymphoma / Cutaneous B-Cell Non-Hodgkin Lymphoma / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Graft Versus Host Disease (GVHD) / Intraocular Lymphoma / Myelodysplastic Syndrome With Isolated Del(5q) / Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable / Nodal marginal zone B-cell lymphomas / Noncontiguous Stage II Adult Burkitt Lymphoma / Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma / Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma / Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma / Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma / Noncontiguous Stage II Adult Lymphoblastic Lymphoma / Noncontiguous Stage II Grade 1 Follicular Lymphoma / Noncontiguous Stage II Grade 2 Follicular Lymphoma / Noncontiguous Stage II Grade 3 Follicular Lymphoma / Noncontiguous Stage II Mantle Cell Lymphoma / Noncontiguous Stage II Marginal Zone Lymphoma / Noncontiguous Stage II Small Lymphocytic Lymphoma / Post Transplant Lymphoproliferative Disorder / Primary Central Nervous System Hodgkin Lymphoma / Primary Central Nervous System Non-Hodgkin Lymphoma / Recurrent Adult Acute Myeloid Leukemia / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Grade III Lymphomatoid Granulomatosis / Recurrent Adult Hodgkin's Lymphoma / Recurrent Adult Immunoblastic Large Cell Lymphoma / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Small Lymphocytic Lymphoma / Refractory Anemia / Refractory Anemia With Excess Blasts / Refractory Anemia With Ringed Sideroblasts / Refractory Cytopenia With Multilineage Dysplasia / Refractory Hairy Cell Leukemia / Relapsing Chronic Myelogenous Leukemia / Secondary Central Nervous System Hodgkin Lymphoma / Secondary Central Nervous System Non-Hodgkin Lymphoma / Small Intestine Lymphoma / Splenic Marginal Zone Lymphoma / Stage I Adult Burkitt Lymphoma / Stage I Adult Diffuse Large Cell Lymphoma / Stage I Adult Diffuse Mixed Cell Lymphoma / Stage I Adult Diffuse Small Cleaved Cell Lymphoma / Stage I Adult Hodgkin Lymphoma / Stage I Adult Immunoblastic Large Cell Lymphoma / Stage I Adult Lymphoblastic Lymphoma / Stage I Chronic Lymphocytic Leukemia / Stage I Grade 1 Follicular Lymphoma / Stage I Grade 2 Follicular Lymphoma / Stage I Grade 3 Follicular Lymphoma / Stage I Mantle Cell Lymphoma / Stage I Marginal Zone Lymphoma / Stage I Small Lymphocytic Lymphoma / Stage II Adult Hodgkin Lymphoma / Stage II Chronic Lymphocytic Leukemia / Stage III Adult Burkitt Lymphoma / Stage III Adult Diffuse Large Cell Lymphoma / Stage III Adult Diffuse Mixed Cell Lymphoma / Stage III Adult Diffuse Small Cleaved Cell Lymphoma / Stage III Adult Hodgkin Lymphoma / Stage III Adult Immunoblastic Large Cell Lymphoma / Stage III Adult Lymphoblastic Lymphoma / Stage III Chronic Lymphocytic Leukemia / Stage III Grade 1 Follicular Lymphoma / Stage III Grade 2 Follicular Lymphoma / Stage III Grade 3 Follicular Lymphoma / Stage III Mantle Cell Lymphoma / Stage III Marginal Zone Lymphoma / Stage IV Adult Burkitt Lymphoma / Stage IV Adult Diffuse Large Cell Lymphoma / Stage IV Adult Diffuse Mixed Cell Lymphoma / Stage IV Adult Diffuse Small Cleaved Cell Lymphoma / Stage IV Adult Hodgkin Lymphoma / Stage IV Adult Immunoblastic Large Cell Lymphoma / Stage IV Adult Lymphoblastic Lymphoma / Stage IV Chronic Lymphocytic Leukemia / Stage IV Grade 1 Follicular Lymphoma / Stage IV Grade 2 Follicular Lymphoma / Stage IV Grade 3 Follicular Lymphoma / Stage IV Mantle Cell Lymphoma / Stage IV Marginal Zone Lymphoma / Stage IV Small Lymphocytic Lymphoma / Testicular Lymphoma / Waldenström's Macroglobulinemia (WM)	1
2	Completed	Supportive Care	Acute Lymphocytic Leukemia (ALL) / Leukemia Acute Myeloid Leukemia (AML) / Myelodysplastic Syndrome	1
2	Completed	Supportive Care	Breast Cancer / Chronic Myeloproliferative Disorders / Gestational Trophoblastic Disease / Graft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases / Neuroblastomas / Ovarian Cancer / Testicular germ cell tumour	1
2	Completed	Supportive Care	Chronic Myeloproliferative Disorders / Graft Versus Host Disease (GVHD) / Infection / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Neoplasms / Precancerous Conditions / Secondary Myelofibrosis / Small Intestine Cancer	1
2	Completed	Supportive Care	Chronic Myeloproliferative Disorders / Graft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases	1
2	Completed	Treatment	Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Adult Acute Lymphoblastic Leukemia in Remission / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11 / Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); RUNX1-RUNX1T1 / Adult Acute Myeloid Leukemia With t(9;11)(p22;q23); MLLT3- / Adult Acute Myeloid Leukemia With t(9;11)(p22;q23); MLLT3-MLL / Adult Acute Promyelocytic Leukemia With t(15;17)(q22;q12); PML-RARA / Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative / Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Childhood Acute Lymphoblastic Leukemia in Remission / Childhood Acute Myeloid Leukemia in Remission / Childhood Burkitt Lymphoma / Childhood Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Childhood Diffuse Large Cell Lymphoma / Childhood Immunoblastic Lymphoma / Childhood Myelodysplastic Syndrome / Chronic Lymphocytic Leukemia (CLL) - Refractory / Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable / Previously Treated Myelodysplastic Syndromes / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Hodgkin's Lymphoma / Recurrent Adult Immunoblastic Lymphoma / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Acute Myeloid Leukemia / Recurrent Childhood Anaplastic Large Cell Lymphoma / Recurrent Childhood Burkitt Lymphoma / Recurrent Childhood Hodgkin Lymphoma / Recurrent Childhood Large Cell Lymphoma / Recurrent Childhood Lymphoblastic Lymphoma / Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Small Lymphocytic Lymphoma / Refractory Plasma Cell Myeloma / Secondary Myelodysplastic Syndromes / Stage I Adult Burkitt Lymphoma / Stage I Adult Diffuse Large Cell Lymphoma / Stage I Adult Diffuse Mixed Cell Lymphoma / Stage I Adult Immunoblastic Lymphoma / Stage I Adult Lymphoblastic Lymphoma / Stage I Childhood Anaplastic Large Cell Lymphoma / Stage I Childhood Burkitt Lymphoma / Stage I Childhood Large Cell Lymphoma / Stage I Childhood Lymphoblastic Lymphoma / Stage I Grade 1 Follicular Lymphoma / Stage I Grade 2 Follicular Lymphoma / Stage I Grade 3 Follicular Lymphoma / Stage I Mantle Cell Lymphoma / Stage I Marginal Zone Lymphoma / Stage I Small Lymphocytic Lymphoma / Stage II Adult Contiguous Immunoblastic Lymphoma / Stage II Adult Non-Contiguous Immunoblastic Lymphoma / Stage II Childhood Anaplastic Large Cell Lymphoma / Stage II Childhood Burkitt Lymphoma / Stage II Childhood Lymphoblastic Lymphoma / Stage II Contiguous Adult Burkitt Lymphoma / Stage II Contiguous Adult Diffuse Large Cell Lymphoma / Stage II Contiguous Adult Diffuse Mixed Cell Lymphoma / Stage II Contiguous Adult Diffuse Small Cleaved Cell Lymphoma / Stage II Contiguous Adult Lymphoblastic Lymphoma / Stage II Contiguous Mantle Cell Lymphoma / Stage II Grade 1 Contiguous Follicular Lymphoma / Stage II Grade 1 Non-Contiguous Follicular Lymphoma / Stage II Grade 2 Contiguous Follicular Lymphoma / Stage II Grade 2 Non-Contiguous Follicular Lymphoma / Stage II Grade 3 Contiguous Follicular Lymphoma / Stage II Grade 3 Non-Contiguous Follicular Lymphoma / Stage II Non-Contiguous Adult Burkitt Lymphoma / Stage II Non-Contiguous Adult Diffuse Large Cell Lymphoma / Stage II Non-Contiguous Adult Diffuse Mixed Cell Lymphoma / Stage II Non-Contiguous Adult Diffuse Small Cleaved Cell Lymphoma / Stage II Non-Contiguous Adult Lymphoblastic Lymphoma / Stage II Non-Contiguous Mantle Cell Lymphoma / Stage II Small Lymphocytic Lymphoma / Stage III Adult Burkitt Lymphoma / Stage III Adult Diffuse Large Cell Lymphoma / Stage III Adult Diffuse Mixed Cell Lymphoma / Stage III Adult Diffuse Small Cleaved Cell Lymphoma / Stage III Adult Immunoblastic Lymphoma / Stage III Adult Lymphoblastic Lymphoma / Stage III Childhood Anaplastic Large Cell Lymphoma / Stage III Childhood Burkitt Lymphoma / Stage III Childhood Large Cell Lymphoma / Stage III Childhood Lymphoblastic Lymphoma / Stage III Grade 1 Follicular Lymphoma / Stage III Grade 2 Follicular Lymphoma / Stage III Grade 3 Follicular Lymphoma / Stage III Mantle Cell Lymphoma / Stage III Marginal Zone Lymphoma / Stage III Small Lymphocytic Lymphoma / Stage IV Adult Burkitt Lymphoma / Stage IV Adult Diffuse Large Cell Lymphoma / Stage IV Adult Diffuse Mixed Cell Lymphoma / Stage IV Adult Diffuse Small Cleaved Cell Lymphoma / Stage IV Adult Immunoblastic Lymphoma / Stage IV Adult Lymphoblastic Lymphoma / Stage IV Childhood Anaplastic Large Cell Lymphoma / Stage IV Childhood Burkitt Lymphoma / Stage IV Childhood Large Cell Lymphoma / Stage IV Childhood Lymphoblastic Lymphoma / Stage IV Grade 1 Follicular Lymphoma / Stage IV Grade 2 Follicular Lymphoma / Stage IV Grade 3 Follicular Lymphoma / Stage IV Mantle Cell Lymphoma / Stage IV Marginal Zone Lymphoma / Stage IV Small Lymphocytic Lymphoma / Waldenström's Macroglobulinemia (WM)	1
2	Completed	Treatment	Accelerated Phase Chronic Myelogenous Leukemia / Adult Acute Lymphoblastic Leukemia in Remission / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Adult Grade III Lymphomatoid Granulomatosis / Adult Nasal Type Extranodal NK/T-Cell Lymphoma / Anaplastic Large Cell Lymphoma / Angioimmunoblastic T-Cell Lymphoma / Aplastic Anemia / Burkitt's Lymphoma / Childhood Acute Lymphoblastic Leukemia in Remission / Childhood Acute Myeloid Leukemia in Remission / Childhood Chronic Myelogenous Leukemia / Childhood Diffuse Large Cell Lymphoma / Childhood Grade III Lymphomatoid Granulomatosis / Childhood Immunoblastic Large Cell Lymphoma / Childhood Myelodysplastic Syndromes / Childhood Nasal Type Extranodal NK/T-cell Lymphoma / Chronic Lymphocytic Leukemia (CLL) - Refractory / Chronic Myelomonocytic Leukemia / Chronic Phase Chronic Myelogenous Leukemia / Congenital Amegakaryocytic Thrombocytopenia / Congenital Hypoplastic Anemia / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Hepatosplenic T-Cell Lymphoma / Juvenile Myelomonocytic Leukemia / Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable / Nodal marginal zone B-cell lymphomas / Paroxysmal Nocturnal Haemoglobinuria (PNH) / Peripheral T-Cell Lymphoma (PTCL) / Polycythemia Vera (PV) / Post Transplant Lymphoproliferative Disorder / Previously Treated Myelodysplastic Syndromes / Primary Myelofibrosis / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Grade III Lymphomatoid Granulomatosis / Recurrent Adult Hodgkin's Lymphoma / Recurrent Adult Immunoblastic Large Cell Lymphoma / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Adult T-Cell Leukemia/Lymphoma / Recurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Acute Myeloid Leukemia / Recurrent Childhood Anaplastic Large Cell Lymphoma / Recurrent Childhood Grade III Lymphomatoid Granulomatosis / Recurrent Childhood Large Cell Lymphoma / Recurrent Childhood Lymphoblastic Lymphoma / Recurrent Childhood Small Noncleaved Cell Lymphoma / Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Mycosis Fungoides/Sezary Syndrome / Recurrent Small Lymphocytic Lymphoma / Recurrent/Refractory Childhood Hodgkin Lymphoma / Refractory Hairy Cell Leukemia / Refractory Multiple Myeloma / Secondary Acute Myeloid Leukemia (Secondary AML, sAML) / Secondary Myelodysplastic Syndromes / Secondary Myelofibrosis / Severe Combined Immunodeficiency / Severe Congenital Neutropenia / Shwachman-Diamond Syndrome / Splenic Marginal Zone Lymphoma / T-Cell Large Granular Lymphocyte Leukemia / Waldenström's Macroglobulinemia (WM) / Wiskott-Aldrich Syndrome (WAS)	1
2	Completed	Treatment	Accelerated Phase Chronic Myelogenous Leukemia / Adult Acute Lymphoblastic Leukemia in Remission / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Adult Nasal Type Extranodal NK/T-Cell Lymphoma / Anaplastic Large Cell Lymphoma / Angioimmunoblastic T-Cell Lymphoma / Blastic Phase Chronic Myelogenous Leukemia / Childhood Acute Lymphoblastic Leukemia in Remission / Childhood Acute Myeloid Leukemia in Remission / Childhood Burkitt Lymphoma / Childhood Chronic Myelogenous Leukemia / Childhood Diffuse Large Cell Lymphoma / Childhood Immunoblastic Large Cell Lymphoma / Childhood Myelodysplastic Syndromes / Childhood Nasal Type Extranodal NK/T-cell Lymphoma / Chronic Lymphocytic Leukemia (CLL) - Refractory / Chronic Phase Chronic Myelogenous Leukemia / Contiguous Stage II Adult Burkitt Lymphoma / Contiguous Stage II Adult Diffuse Large Cell Lymphoma / Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma / Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma / Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma / Contiguous Stage II Adult Lymphoblastic Lymphoma / Contiguous Stage II Grade 1 Follicular Lymphoma / Contiguous Stage II Grade 2 Follicular Lymphoma / Contiguous Stage II Grade 3 Follicular Lymphoma / Contiguous Stage II Mantle Cell Lymphoma / Contiguous Stage II Marginal Zone Lymphoma / Contiguous Stage II Small Lymphocytic Lymphoma / Cutaneous B-Cell Non-Hodgkin Lymphoma / De Novo Myelodysplastic Syndromes / Essential Thrombocythemia (ET) / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Hepatosplenic T-Cell Lymphoma / Intraocular Lymphoma / Leukemia, Prolymphocytic / Nodal marginal zone B-cell lymphomas / Noncontiguous Stage II Adult Burkitt Lymphoma / Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma / Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma / Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma / Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma / Noncontiguous Stage II Adult Lymphoblastic Lymphoma / Noncontiguous Stage II Grade 1 Follicular Lymphoma / Noncontiguous Stage II Grade 2 Follicular Lymphoma / Noncontiguous Stage II Grade 3 Follicular Lymphoma / Noncontiguous Stage II Mantle Cell Lymphoma / Noncontiguous Stage II Marginal Zone Lymphoma / Noncontiguous Stage II Small Lymphocytic Lymphoma / Noncutaneous Extranodal Lymphoma / Peripheral T-Cell Lymphoma (PTCL) / Polycythemia Vera (PV) / Post Transplant Lymphoproliferative Disorder / Previously Treated Myelodysplastic Syndromes / Primary Myelofibrosis / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Grade III Lymphomatoid Granulomatosis / Recurrent Adult Hodgkin's Lymphoma / Recurrent Adult Immunoblastic Large Cell Lymphoma / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Adult T-Cell Leukemia/Lymphoma / Recurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Acute Myeloid Leukemia / Recurrent Childhood Anaplastic Large Cell Lymphoma / Recurrent Childhood Grade III Lymphomatoid Granulomatosis / Recurrent Childhood Large Cell Lymphoma / Recurrent Childhood Lymphoblastic Lymphoma / Recurrent Childhood Small Noncleaved Cell Lymphoma / Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Mycosis Fungoides/Sezary Syndrome / Recurrent Small Lymphocytic Lymphoma / Recurrent/Refractory Childhood Hodgkin Lymphoma / Refractory Hairy Cell Leukemia / Refractory Multiple Myeloma / Relapsing Chronic Myelogenous Leukemia / Small Intestine Lymphoma / Splenic Marginal Zone Lymphoma / Stage I Adult Burkitt Lymphoma / Stage I Adult Diffuse Large Cell Lymphoma / Stage I Adult Diffuse Mixed Cell Lymphoma / Stage I Adult Diffuse Small Cleaved Cell Lymphoma / Stage I Adult Immunoblastic Large Cell Lymphoma / Stage I Adult Lymphoblastic Lymphoma / Stage I Adult T-Cell Leukemia/Lymphoma / Stage I Childhood Anaplastic Large Cell Lymphoma / Stage I Childhood Large Cell Lymphoma / Stage I Childhood Lymphoblastic Lymphoma / Stage I Childhood Small Noncleaved Cell Lymphoma / Stage I Chronic Lymphocytic Leukemia / Stage I Cutaneous T-cell Non-Hodgkin Lymphoma / Stage I Grade 1 Follicular Lymphoma / Stage I Grade 2 Follicular Lymphoma / Stage I Grade 3 Follicular Lymphoma / Stage I Mantle Cell Lymphoma / Stage I Marginal Zone Lymphoma / Stage I Multiple Myeloma / Stage I Small Lymphocytic Lymphoma / Stage IA Mycosis Fungoides/Sezary Syndrome / Stage IB Mycosis Fungoides/Sezary Syndrome / Stage II Adult T-Cell Leukemia/Lymphoma / Stage II Childhood Anaplastic Large Cell Lymphoma / Stage II Childhood Large Cell Lymphoma / Stage II Childhood Lymphoblastic Lymphoma / Stage II Childhood Small Noncleaved Cell Lymphoma / Stage II Chronic Lymphocytic Leukemia / Stage II Cutaneous T-cell Non-Hodgkin Lymphoma / Stage II Multiple Myeloma / Stage IIA Mycosis Fungoides/Sezary Syndrome / Stage IIB Mycosis Fungoides/Sezary Syndrome / Stage III Adult Burkitt Lymphoma / Stage III Adult Diffuse Large Cell Lymphoma / Stage III Adult Diffuse Mixed Cell Lymphoma / Stage III Adult Diffuse Small Cleaved Cell Lymphoma / Stage III Adult Immunoblastic Large Cell Lymphoma / Stage III Adult Lymphoblastic Lymphoma / Stage III Adult T-Cell Leukemia/Lymphoma / Stage III Childhood Anaplastic Large Cell Lymphoma / Stage III Childhood Large Cell Lymphoma / Stage III Childhood Lymphoblastic Lymphoma / Stage III Childhood Small Noncleaved Cell Lymphoma / Stage III Chronic Lymphocytic Leukemia / Stage III Cutaneous T-Cell Non-Hodgkin Lymphoma / Stage III Grade 1 Follicular Lymphoma / Stage III Grade 2 Follicular Lymphoma / Stage III Grade 3 Follicular Lymphoma / Stage III Mantle Cell Lymphoma / Stage III Marginal Zone Lymphoma / Stage III Multiple Myeloma / Stage III Small Lymphocytic Lymphoma / Stage IIIA Mycosis Fungoides/Sezary Syndrome / Stage IIIB Mycosis Fungoides/Sezary Syndrome / Stage IV Adult Burkitt Lymphoma / Stage IV Adult Diffuse Large Cell Lymphoma / Stage IV Adult Diffuse Mixed Cell Lymphoma / Stage IV Adult Diffuse Small Cleaved Cell Lymphoma / Stage IV Adult Immunoblastic Large Cell Lymphoma / Stage IV Adult Lymphoblastic Lymphoma / Stage IV Adult T-Cell Leukemia/Lymphoma / Stage IV Childhood Anaplastic Large Cell Lymphoma / Stage IV Childhood Large Cell Lymphoma / Stage IV Childhood Lymphoblastic Lymphoma / Stage IV Childhood Small Noncleaved Cell Lymphoma / Stage IV Chronic Lymphocytic Leukemia / Stage IV Cutaneous T-Cell Non-Hodgkin Lymphoma / Stage IV Grade 1 Follicular Lymphoma / Stage IV Grade 2 Follicular Lymphoma / Stage IV Grade 3 Follicular Lymphoma / Stage IV Mantle Cell Lymphoma / Stage IV Marginal Zone Lymphoma / Stage IV Small Lymphocytic Lymphoma / Stage IVA Mycosis Fungoides/Sezary Syndrome / Stage IVB Mycosis Fungoides/Sezary Syndrome / Testicular Lymphoma / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Adult Acute Myeloid Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia / Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies / Waldenström's Macroglobulinemia (WM)	1
2	Completed	Treatment	Accelerated Phase Chronic Myelogenous Leukemia / Adult Acute Lymphoblastic Leukemia in Remission / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Adult Nasal Type Extranodal NK/T-Cell Lymphoma / Anaplastic Large Cell Lymphoma / Angioimmunoblastic T-Cell Lymphoma / Childhood Acute Lymphoblastic Leukemia in Remission / Childhood Acute Myeloid Leukemia in Remission / Childhood Burkitt Lymphoma / Childhood Chronic Myelogenous Leukemia / Childhood Myelodysplastic Syndromes / Childhood Nasal Type Extranodal NK/T-cell Lymphoma / Chronic Lymphocytic Leukemia (CLL) - Refractory / Cutaneous B-Cell Non-Hodgkin Lymphoma / De Novo Myelodysplastic Syndromes / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Hematopoietic/Lymphoid Cancer / Hepatosplenic T-Cell Lymphoma / Intraocular Lymphoma / Nodal marginal zone B-cell lymphomas / Peripheral T-Cell Lymphoma (PTCL) / Post Transplant Lymphoproliferative Disorder / Previously Treated Myelodysplastic Syndromes / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Grade III Lymphomatoid Granulomatosis / Recurrent Adult Hodgkin's Lymphoma / Recurrent Adult Immunoblastic Large Cell Lymphoma / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Adult T-Cell Leukemia/Lymphoma / Recurrent Childhood Anaplastic Large Cell Lymphoma / Recurrent Childhood Grade III Lymphomatoid Granulomatosis / Recurrent Childhood Large Cell Lymphoma / Recurrent Childhood Lymphoblastic Lymphoma / Recurrent Childhood Small Noncleaved Cell Lymphoma / Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Mycosis Fungoides/Sezary Syndrome / Recurrent Small Lymphocytic Lymphoma / Recurrent/Refractory Childhood Hodgkin Lymphoma / Refractory Multiple Myeloma / Relapsing Chronic Myelogenous Leukemia / Secondary Myelodysplastic Syndromes / Small Intestine Lymphoma / Splenic Marginal Zone Lymphoma / Stage II Multiple Myeloma / Stage III Adult Burkitt Lymphoma / Stage III Adult Diffuse Large Cell Lymphoma / Stage III Adult Diffuse Mixed Cell Lymphoma / Stage III Adult Diffuse Small Cleaved Cell Lymphoma / Stage III Adult Hodgkin Lymphoma / Stage III Adult Immunoblastic Large Cell Lymphoma / Stage III Adult Lymphoblastic Lymphoma / Stage III Adult T-Cell Leukemia/Lymphoma / Stage III Childhood Hodgkin Lymphoma / Stage III Chronic Lymphocytic Leukemia / Stage III Cutaneous T-Cell Non-Hodgkin Lymphoma / Stage III Grade 1 Follicular Lymphoma / Stage III Grade 2 Follicular Lymphoma / Stage III Grade 3 Follicular Lymphoma / Stage III Mantle Cell Lymphoma / Stage III Marginal Zone Lymphoma / Stage III Multiple Myeloma / Stage III Mycosis Fungoides/Sezary Syndrome / Stage III Small Lymphocytic Lymphoma / Stage IV Adult Burkitt Lymphoma / Stage IV Adult Diffuse Large Cell Lymphoma / Stage IV Adult Diffuse Mixed Cell Lymphoma / Stage IV Adult Diffuse Small Cleaved Cell Lymphoma / Stage IV Adult Hodgkin Lymphoma / Stage IV Adult Immunoblastic Large Cell Lymphoma / Stage IV Adult Lymphoblastic Lymphoma / Stage IV Adult T-Cell Leukemia/Lymphoma / Stage IV Childhood Hodgkin Lymphoma / Stage IV Chronic Lymphocytic Leukemia / Stage IV Cutaneous T-Cell Non-Hodgkin Lymphoma / Stage IV Grade 1 Follicular Lymphoma / Stage IV Grade 2 Follicular Lymphoma / Stage IV Grade 3 Follicular Lymphoma / Stage IV Mantle Cell Lymphoma / Stage IV Marginal Zone Lymphoma / Stage IV Mycosis Fungoides/Sezary Syndrome / Stage IV Small Lymphocytic Lymphoma / Testicular Lymphoma / Waldenström's Macroglobulinemia (WM)	1
2	Completed	Treatment	Accelerated Phase Chronic Myelogenous Leukemia / Adult Acute Lymphoblastic Leukemia in Remission / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Blastic Phase Chronic Myelogenous Leukemia / Childhood Acute Lymphoblastic Leukemia in Remission / Childhood Acute Myeloid Leukemia in Remission / Childhood Chronic Myelogenous Leukemia / Childhood Myelodysplastic Syndromes / Chronic Myelomonocytic Leukemia / De Novo Myelodysplastic Syndromes / Previously Treated Myelodysplastic Syndromes / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Recurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Acute Myeloid Leukemia / Secondary Myelodysplastic Syndromes / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia	1
2	Completed	Treatment	Accelerated Phase Chronic Myelogenous Leukemia / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Blastic Phase Chronic Myelogenous Leukemia / Childhood Acute Myeloid Leukemia in Remission / Childhood Chronic Myelogenous Leukemia / Childhood Myelodysplastic Syndromes / Chronic Phase Chronic Myelogenous Leukemia / De Novo Myelodysplastic Syndromes / Hematopoietic/Lymphoid Cancer / Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable / Previously Treated Myelodysplastic Syndromes / Recurrent Adult Acute Myeloid Leukemia / Recurrent Childhood Acute Myeloid Leukemia / Relapsing Chronic Myelogenous Leukemia	1
2	Completed	Treatment	Acute Lymphocytic Leukemia (ALL) / Advanced Myeloproliferative Disease / Chronic Myeloid Leukemia (CML) / Leukemia Acute Myeloid Leukemia (AML) / Lymphoproliferative Disease / Multiple Myeloma (MM) / Myelodysplasia / Non-Hodgkin's Lymphoma (NHL) / Severe Aplastic Anemia (SAA)	1
2	Completed	Treatment	Acute Lymphocytic Leukemia (ALL) / Aplastic Anemia / Biphenotypic Leukemia / Chronic Lymphocytic Leukaemia (CLL) / Chronic Myeloid Leukemia (CML) / Hodgkins Disease (HD) / Leukemia Acute Myeloid Leukemia (AML) / Malignant Lymphomas / Myelodysplastic Syndromes / Plasma Cell Neoplasms	1
2	Completed	Treatment	Acute Lymphocytic Leukemia (ALL) / Chronic Lymphocytic Leukaemia (CLL) / Immune System Diseases / Leukemia Acute Myeloid Leukemia (AML) / Malignant Lymphomas / Myelodysplastic Syndromes	1
2	Completed	Treatment	Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome / Adult Acute Myeloid Leukemia in Remission	1
2	Completed	Treatment	Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / De Novo Myelodysplastic Syndromes / Previously Treated Myelodysplastic Syndromes / Recurrent Adult Acute Myeloid Leukemia / Secondary Acute Myeloid Leukemia (Secondary AML, sAML)	1
2	Completed	Treatment	Adult Acute Lymphoblastic Leukemia in Remission	1
2	Completed	Treatment	Amyotrophic Lateral Sclerosis (ALS)	1
2	Completed	Treatment	Aplastic Anemia / Chronic Myeloproliferative Disorders / Congenital Hypoplastic Anemia / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases	1
2	Completed	Treatment	Asthma	1
2	Completed	Treatment	Atopic Dermatitis (AD)	5
2	Completed	Treatment	B-Cell Prolymphocytic Leukemia / Chronic Lymphocytic Leukemia (CLL) - Refractory / Chronic, recurrent Lymphocytic Leukemia / Hypodiploidy / Leukemia, Plasma Cell / Loss of Chromosome 17p / Progression of Multiple Myeloma or Plasma Cell Leukemia / Recurrent Adult Hodgkin's Lymphoma / Recurrent Adult Non-Hodgkin Lymphoma / Recurrent Childhood Hodgkin Lymphoma / Recurrent Childhood Non-Hodgkin Lymphoma / Recurrent Plasma Cell Myeloma / Recurrent Small Lymphocytic Lymphoma / Refractory Childhood Hodgkin Lymphoma / Refractory Non-Hodgkin's lymphoma / Refractory Plasma Cell Myeloma / Refractory Small Lymphocytic Lymphoma / T(14;16) / T(4;14) / T-Cell Prolymphocytic Leukemia / Waldenström's Macroglobulinemia (WM)	1
2	Completed	Treatment	Blood Stem Cell Transplant Failure / Leukemias / Malignancies, Hematologic	1
2	Completed	Treatment	Bronchial Asthma	2
2	Completed	Treatment	CD20 Positive / Hematopoietic and Lymphoid Cell Neoplasm / Lymphocytic Neoplasm / Malignant Lymphomas	1
2	Completed	Treatment	Chronic Hepatitis C Virus (HCV) Infection	1
2	Completed	Treatment	Chronic Chronic myelogenous leukemia / Chronic Lymphocytic Leukaemia (CLL) / Leukemia Acute Myeloid Leukemia (AML) / Leukemias / Lymphoma, Hodgkins / Multiple Myeloma (MM) / Myelodysplastic Syndrome / Non-Hodgkin's Lymphoma (NHL)	1
2	Completed	Treatment	Chronic Myeloproliferative Disorders / Graft Versus Host Disease (GVHD) / Leukemias / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases	1
2	Completed	Treatment	Chronic Myeloproliferative Disorders / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes	1
2	Completed	Treatment	Chronic Myeloproliferative Disorders / Leukemias / Myelodysplastic/Myeloproliferative Diseases	1
2	Completed	Treatment	Chronic Renal Failure (CRF) / Transplantation, Kidney	1
2	Completed	Treatment	Crohn's Disease (CD)	1
2	Completed	Treatment	Cutaneous Lupus Erythematosus (CLE)	1
2	Completed	Treatment	Diabetes Mellitus, Insulin-Dependent	1
2	Completed	Treatment	Disorder Related to Renal Transplantation	1
2	Completed	Treatment	Disorders, Lymphoproliferative / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Neoplasms	1
2	Completed	Treatment	Graft Versus Host Disease (GVHD)	2
2	Completed	Treatment	Graft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases / Secondary Myelofibrosis	1
2	Completed	Treatment	Graft Versus Host Disease (GVHD) / Leukemias / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Neoplasms	1
2	Completed	Treatment	Graft Versus Host Disease (GVHD) / Malignancies, Hematologic	1
2	Completed	Treatment	Graft Versus Host Disease (GVHD) / Malignant Lymphomas	1
2	Completed	Treatment	Graft Versus Host Disease (GVHD) / Transplantation, Bone Marrow	2
2	Completed	Treatment	Haematological Malignancies	1
2	Completed	Treatment	Heart Transplantation / Transplantation, Kidney / Transplantation, Liver	1
2	Completed	Treatment	Hemorrhagic Hereditary Telangiectasia (HHT)	1
2	Completed	Treatment	Hepatic Failure	2
2	Completed	Treatment	Hepatocellular,Carcinoma	1
2	Completed	Treatment	Hodgkins Disease (HD)	1
2	Completed	Treatment	Hodgkins Disease (HD) / Leukaemia, Lymphoblastic / Multiple Myeloma (MM) / Myelogenous Leukemia / Non-Hodgkin's Lymphoma (NHL)	1
2	Completed	Treatment	Hypoglycemia / Metabolic Diseases / Type 1 Diabetes Mellitus	1
2	Completed	Treatment	IgA Nephropathy	1
2	Completed	Treatment	Juvenile Myelomonocytic Leukemia	1
2	Completed	Treatment	Kidney Diseases	1
2	Completed	Treatment	Leukemias / Malignant Lymphomas	2
2	Completed	Treatment	Leukemias / Malignant Lymphomas / Multiple Myeloma (MM) / Myelodysplastic Syndromes / Myeloproliferative Neoplasms / Plasma Cell Neoplasms	1
2	Completed	Treatment	Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes	2
2	Completed	Treatment	Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases / Myeloproliferative Disorders / Renal Cancers	1
2	Completed	Treatment	Leukemias / Malignant Lymphomas / Myelodysplastic Syndrome	1
2	Completed	Treatment	Leukemias / Malignant Lymphomas / Myelodysplastic Syndromes	2
2	Completed	Treatment	Leukemias / Malignant Lymphomas / Transplantation, Stem Cell	1
2	Completed	Treatment	Leukemias / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases	1
2	Completed	Treatment	Chronic Chronic myelogenous leukemia / Leukemias	1
2	Completed	Treatment	Liver Diseases / Transplantation, Liver	1
2	Completed	Treatment	Malignancies, Hematologic	1
2	Completed	Treatment	Multiple Myeloma (MM) / Plasma Cell Neoplasms	1
2	Completed	Treatment	Multiple Myeloma and Plasma Cell Neoplasm	1
2	Completed	Treatment	Oral Chronic Graft-Versus-Host Disease	1
2	Completed	Treatment	Oral Lichen Planus	1
2	Completed	Treatment	Psoriasis	1
2	Completed	Treatment	Pulmonary Arterial Hypertension (PAH)	1
2	Completed	Treatment	Renal Cancers	2
2	Completed	Treatment	Renal Failure	3
2	Completed	Treatment	Sarcomas	1
2	Completed	Treatment	Transplant, Kidney	1
2	Completed	Treatment	Transplantation, Kidney	6
2	Completed	Treatment	Transplantation, Liver	2
2	Completed	Treatment	Type 1 Diabetes Mellitus	4
2	Completed	Treatment	Vulvar Lichen Sclerosus	1
2	Enrolling by Invitation	Treatment	Graft Versus Host Disease (GVHD)	1
2	Enrolling by Invitation	Treatment	Heart Transplantation	1
2	Not Yet Recruiting	Prevention	Allogeneic Stem Cell Transplant Recipient / Hematologic and Lymphocytic Disorder / Hematopoietic and Lymphoid Cell Neoplasm	1
2	Not Yet Recruiting	Treatment	Acute Lymphoblastic Leukaemias (ALL) / High Risk Myelodysplastic Syndrome / Leukemia Acute Myeloid Leukemia (AML) / Myelodysplastic Syndrome	1
2	Not Yet Recruiting	Treatment	Acute Lymphoblastic Leukemia in Remission / Acute myeloid leukaemia (in remission) / Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome / Acute, recurrent Myeloid Leukemia / Agnogenic Myeloid Metaplasia / Blasts 5 Percent or Less of Bone Marrow Nucleated Cells / Chronic Myelomonocytic Leukemia / Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Donor / Minimal Residual Disease / Myelodysplastic Syndrome / Myeloproliferative Neoplasms / Recurrent Hodgkin Lymphoma / Recurrent Non-Hodgkin Lymphoma / Refractory Acute Myelogenous Leukemia (AML) / Therapy-Related Acute Myeloid Leukemia	1
2	Not Yet Recruiting	Treatment	Alzheimer's Disease (AD) / Mild Cognitive Impairment (MCI)	1
2	Not Yet Recruiting	Treatment	Leukemia Acute Myeloid Leukemia (AML)	1
2	Not Yet Recruiting	Treatment	Recipients of Liver Transplant	1
2	Not Yet Recruiting	Treatment	Recurrent Aggressive Non-Hodgkin Lymphoma / Recurrent B-Cell Non-Hodgkin Lymphoma / Recurrent Burkitt Lymphoma / Recurrent Diffuse Large B-Cell Lymphoma / Recurrent High Grade B-Cell Lymphoma / Recurrent T-Cell Non-Hodgkin Lymphoma / Recurrent Transformed B-cell Non-Hodgkin Lymphoma	1
2	Not Yet Recruiting	Treatment	Recurrent Plasma Cell Myeloma	1
2	Recruiting	Prevention	Acute Lymphocytic Leukemia (ALL) / Chronic Lymphocytic Leukaemia (CLL) / Leukemia Acute Myeloid Leukemia (AML) / Myelodysplastic Syndrome / Non-Hodgkin's Lymphoma (NHL)	1
2	Recruiting	Prevention	Graft Versus Host Disease (GVHD) / Hematopoietic Stem Cell Transplantation (HSCT)	1
2	Recruiting	Supportive Care	Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma / Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Follicular Lymphoma (FL) / Graft Versus Host Disease (GVHD) / Leukemia, Acute / Lymphoma, Hodgkins / Lymphoma, Large B-Cell, Diffuse (DLBCL) / Mantle Cell Lymphoma (MCL) / Marginal Zone Lymphoma (MZL) / Myelodysplastic Syndrome / Myeloproliferative Neoplasms / Recurrent Acute Myeloid Leukemia With Myelodysplasia-Related Changes / Recurrent Plasma Cell Myeloma / Refractory Plasma Cell Myeloma / Secondary Myelodysplastic Syndromes	1
2	Recruiting	Supportive Care	Transplant, Kidney / Transplantation, Liver	1
2	Recruiting	Treatment	Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Acute Biphenotypic Leukemia (ABL) / Acute Leukemias of Ambiguous Lineage / Acute Lymphoblastic Leukaemia Recurrent / Acute Lymphoblastic Leukemia in Remission / Acute myeloid leukaemia (in remission) / Acute Undifferentiated Leukemia (AUL) / Acute, recurrent Myeloid Leukemia / Adult Acute Lymphoblastic Leukemia in Remission / Adult Acute Myeloid Leukemia in Remission / Allogeneic Hematopoietic Stem Cell Transplant Recipient / Allogeneic Hematopoietic Stem Cell Transplantation Recipient / Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) / Childhood Acute Lymphoblastic Leukemia in Remission / Childhood Acute Myeloid Leukemia in Remission / Donor / Graft Versus Host Disease (GVHD) / Lymphoma, Lymphoblastic / Myelodysplastic Syndrome With Excess Blasts / Myelodysplastic Syndrome With Excess Blasts-1 / Myelodysplastic Syndrome With Excess Blasts-2 / RAEB-1 / RAEB-2 / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Recurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Acute Myeloid Leukemia / Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Refractory Acute Lymphoblastic Leukemia / Refractory Acute Myelogenous Leukemia (AML) / Refractory Anemia With Excess Blasts	1
2	Recruiting	Treatment	Accelerated Phase Chronic Myelogenous Leukemia / Adult Acute Lymphoblastic Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Nasal Type Extranodal NK/T-Cell Lymphoma / Anaplastic Large Cell Lymphoma / Angioimmunoblastic T-Cell Lymphoma / Blastic Phase Chronic Myelogenous Leukemia / Childhood Acute Lymphoblastic Leukemia in Remission / Childhood Burkitt Lymphoma / Childhood Chronic Myelogenous Leukemia / Childhood Diffuse Large Cell Lymphoma / Childhood Immunoblastic Large Cell Lymphoma / Childhood Myelodysplastic Syndromes / Childhood Nasal Type Extranodal NK/T-cell Lymphoma / Chronic Myelomonocytic Leukemia / Chronic Phase Chronic Myelogenous Leukemia / Cutaneous B-Cell Non-Hodgkin Lymphoma / De Novo Myelodysplastic Syndromes / Essential Thrombocythemia (ET) / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Hepatosplenic T-Cell Lymphoma / Intraocular Lymphoma / Juvenile Myelomonocytic Leukemia / Nodal marginal zone B-cell lymphomas / Noncutaneous Extranodal Lymphoma / Peripheral T-Cell Lymphoma (PTCL) / Polycythemia Vera (PV) / Post Transplant Lymphoproliferative Disorder / Previously Treated Myelodysplastic Syndromes / Primary Myelofibrosis / Recurrent Adult Acute Myeloid Leukemia / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Grade III Lymphomatoid Granulomatosis / Recurrent Adult Hodgkin's Lymphoma / Recurrent Adult Immunoblastic Large Cell Lymphoma / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Adult T-Cell Leukemia/Lymphoma / Recurrent Childhood Acute Myeloid Leukemia / Recurrent Childhood Anaplastic Large Cell Lymphoma / Recurrent Childhood Grade III Lymphomatoid Granulomatosis / Recurrent Childhood Large Cell Lymphoma / Recurrent Childhood Lymphoblastic Lymphoma / Recurrent Childhood Small Noncleaved Cell Lymphoma / Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Mycosis Fungoides/Sezary Syndrome / Recurrent Small Lymphocytic Lymphoma / Recurrent/Refractory Childhood Hodgkin Lymphoma / Refractory Anemia With Excess Blasts / Refractory Anemia With Excess Blasts in Transformation / Refractory Cytopenia With Multilineage Dysplasia / Refractory Hairy Cell Leukemia / Refractory Multiple Myeloma / Relapsing Chronic Myelogenous Leukemia / Secondary Acute Myeloid Leukemia (Secondary AML, sAML) / Small Intestine Lymphoma / Splenic Marginal Zone Lymphoma / T-Cell Large Granular Lymphocyte Leukemia / Testicular Lymphoma / Waldenström's Macroglobulinemia (WM)	1
2	Recruiting	Treatment	Acute Biphenotypic Leukemia (ABL) / Acute Erythroid Leukemia in Remission / Acute Leukemia in Remission / Acute Lymphoblastic Leukemia in Remission / Acute Megakaryoblastic Leukemia / Acute myeloid leukaemia (in remission) / Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome / Acute Myeloid Leukemia With FLT3/ITD Mutation / Acute Myeloid Leukemia With Inv(3) (q21.3;q26.2) or t(3;3) (q21.3;q26.2); GATA2, MECOM / Acute Myeloid Leukemia With Inv(3) (q21.3;q26.2); GATA2, MECOM / Acute Myeloid Leukemia With Inv(3)(q21q26.2) or t(3;3)(q21;q26.2); RPN1-EVI1 / Acute Myeloid Leukemia With Inv(3)(q21q26.2); RPN1-EVI1 / Acute Myeloid Leukemia With Multilineage Dysplasia / Acute Myeloid Leukemia With t(6;9) (p23;q34.1); DEK-NUP214 / Acute Myeloid Leukemia With t(6;9)(p23;q34); DEK-NUP214 / Acute Undifferentiated Leukemia (AUL) / Adult Acute Lymphoblastic Leukemia in Complete Remission / B Acute Lymphoblastic Leukemia With t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1) / B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 / B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1 / Blasts Under 5 Percent of Bone Marrow Nucleated Cells / Burkitt's Lymphoma / Childhood Acute Lymphoblastic Leukemia in Complete Remission / DS Stage II Plasma Cell Myeloma / DS Stage III Plasma Cell Myeloma / Hematopoietic Cell Transplant Recipient / Myelodysplastic Syndrome / Recurrent Anaplastic Large Cell Lymphoma / Recurrent Diffuse Large B-Cell Lymphoma / Recurrent Follicular Lymphoma / Recurrent Hodgkin Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Plasma Cell Myeloma / Refractory Plasma Cell Myeloma / Secondary Acute Myeloid Leukemia (Secondary AML, sAML) / T Lymphoblastic Lymphoma	1
2	Recruiting	Treatment	Acute Biphenotypic Leukemia (ABL) / Acute Leukemias of Ambiguous Lineage / Acute Lymphoblastic Leukaemias (ALL) / Acute Lymphoblastic Leukemia in Remission / Acute myeloid leukaemia (in remission) / Acute Undifferentiated Leukemia (AUL) / Allogeneic Hematopoietic Stem Cell Transplantation Recipient / Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) / Blasts Under 5 Percent of Bone Marrow Nucleated Cells / Donor / Leukemia Acute Myeloid Leukemia (AML) / Lymphoma, Lymphoblastic / Mixed Phenotype Acute Leukemia (MPAL)	1
2	Recruiting	Treatment	Acute Biphenotypic Leukemia (ABL) / Acute Leukemias of Ambiguous Lineage / Acute Lymphoblastic Leukaemias (ALL) / Acute Undifferentiated Leukemia (AUL) / Allogeneic Hematopoietic Stem Cell Transplantation Recipient / Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) / Blasts Under 25 Percent of Bone Marrow Nucleated Cells / Blasts Under 5 Percent of Bone Marrow Nucleated Cells / Leukemia, Acute / Mixed Phenotype Acute Leukemia (MPAL) / Myelodysplastic Syndrome With Excess Blasts-1 / Myelodysplastic Syndrome With Excess Blasts-2	1
2	Recruiting	Treatment	Acute Lymphoblastic Leukaemia Recurrent / Acute Lymphocytic Leukemia (ALL) / Acute, recurrent Myeloid Leukemia / Chronic Lymphocytic Leukaemia (CLL) / Chronic Myeloid Leukemia (CML) / Disorders, Lymphoproliferative / Hematopoietic and Lymphoid Cell Neoplasm / High Risk Acute Myeloid Leukemia / High Risk Myelodysplastic Syndrome / Leukemia Acute Myeloid Leukemia (AML) / Lymphoma, Hodgkins / Multiple Myeloma (MM) / Myelodysplastic Syndrome / Myelodysplastic/Myeloproliferative Neoplasms / Myeloproliferative Syndromes / Non-Hodgkin's Lymphoma (NHL) / Other Diseases of Blood and Blood-Forming Organs / Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Recurrent High Risk Myelodysplastic Syndrome / Recurrent Hodgkin Lymphoma / Recurrent Myelodysplastic Syndrome / Recurrent Non-Hodgkin Lymphoma / Recurrent Plasma Cell Myeloma	1
2	Recruiting	Treatment	Acute Lymphoblastic Leukaemias (ALL) / Allogeneic Hematopoietic Stem Cell Transplantation Recipient / B Acute Lymphoblastic Leukemia / CD22 Positive / Lymphocytic Neoplasm / Malignant Lymphomas	1
2	Recruiting	Treatment	Acute Lymphoblastic Leukaemias (ALL) / Chronic Myeloid Leukemia (CML) / Granulocytic Sarcoma / Juvenile Myelomonocytic Leukemia (JMML) / Leukemia Acute Myeloid Leukemia (AML) / Myelodysplastic Syndromes (MDS) / Non-Hodgkin's Lymphoma (NHL)	1
2	Recruiting	Treatment	Acute Lymphoblastic Leukaemias (ALL) / Chronic Chronic myelogenous leukemia / Chronic Myelomonocytic Leukemia (CMML) / Graft Versus Host Disease (GVHD) / Hematopoietic Stem Cell Transplantation (HSCT) / Leukemia Acute Myeloid Leukemia (AML) / Leukemias / Myelodysplastic Syndromes (MDS)	1
2	Recruiting	Treatment	Acute Lymphocytic Leukemia (ALL) / Biphenotypic/Undifferentiated Leukemia / Burkitt's Lymphoma / Chronic Chronic myelogenous leukemia / Leukemia Acute Myeloid Leukemia (AML) / Lymphoma, Hodgkins / Lymphoplasmacytic Lymphoma / Mantle Cell Lymphoma (MCL) / Myelodysplasia / Recurrent Cutaneous T-cell lymphoma / Relapsed Large Cell Lymphoma	1
2	Recruiting	Treatment	Acute Lymphocytic Leukemia (ALL) / Burkitt's Lymphoma / Chronic Chronic myelogenous leukemia / Chronic Lymphocytic Leukaemia (CLL) / Follicular Lymphoma (FL) / Hematological Diseases / Leukemia Acute Myeloid Leukemia (AML) / Leukemia, Plasma Cell / Leukemia, Prolymphocytic / Lymphoma, B-Cell / Lymphoma, Lymphoblastic / Lymphoplasmacytic Lymphoma / Mantle Cell Lymphoma (MCL) / Multiple Myeloma (MM) / Myelodysplastic Syndromes / Myeloproliferative Syndromes / Non-Hodgkin's Lymphoma (NHL) / Small Lymphocytic Lymphoma	1
2	Recruiting	Treatment	Acute myeloid leukaemia (in remission) / Aplastic Anemia / Chronic Myelomonocytic Leukemia / Indolent Non-Hodgkin's Lymphomas / Leukemia Acute Myeloid Leukemia (AML) / Lymphoma, Hodgkins / Myelodysplastic Syndrome / Myeloproliferative Neoplasms / Neoplasms, Malignant / Plasma Cell Myeloma / Refractory Anemia / Refractory Anemia With Excess Blasts / Refractory Anemia With Ring Sideroblasts / Refractory Cytopenia With Multilineage Dysplasia / Refractory Cytopenia With Multilineage Dysplasia and Ring Sideroblasts	1
2	Recruiting	Treatment	Adult Acute Lymphoblastic Leukemia in Remission / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Adult Nasal Type Extranodal NK/T-Cell Lymphoma / Aplastic Anemia / Childhood Acute Lymphoblastic Leukemia in Remission / Childhood Acute Myeloid Leukemia in Remission / Childhood Myelodysplastic Syndromes / Chronic Eosinophilic Leukemia (CEL) / Chronic Myelomonocytic Leukemia / Chronic Neutrophilic Leukemia / Essential Thrombocythemia (ET) / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Juvenile Myelomonocytic Leukemia / Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable / Nodal marginal zone B-cell lymphomas / Polycythemia Vera (PV) / Previously Treated Myelodysplastic Syndromes / Primary Myelofibrosis / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Grade III Lymphomatoid Granulomatosis / Recurrent Adult Hodgkin's Lymphoma / Recurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Acute Myeloid Leukemia / Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Mycosis Fungoides/Sezary Syndrome / Recurrent Small Lymphocytic Lymphoma / Recurrent/Refractory Childhood Hodgkin Lymphoma / Refractory Anemia / Refractory Anemia With Ringed Sideroblasts / Refractory Hairy Cell Leukemia / Refractory Multiple Myeloma / Secondary Myelodysplastic Syndromes / Splenic Marginal Zone Lymphoma / T-Cell Large Granular Lymphocyte Leukemia / Urticaria Pigmentosa / Waldenström's Macroglobulinemia (WM)	1
2	Recruiting	Treatment	Antibody-mediated Rejection / Lung Transplant Rejection	1
2	Recruiting	Treatment	Aplastic Anemia / Bone Marrow Failure / Immunosuppression / Severe Aplastic Anemia (SAA)	1
2	Recruiting	Treatment	Atopic Dermatitis (AD)	1
2	Recruiting	Treatment	Bone Marrow Failure / Immune Deficiency Disease / Primary Immune Deficiency Disorders (PIDD)	1
2	Recruiting	Treatment	Cardiac Transplant	1
2	Recruiting	Treatment	Chronic Myelomonocytic Leukemia / Leukemia Acute Myeloid Leukemia (AML) / Myelodysplastic Syndrome	1
2	Recruiting	Treatment	Delayed Graft Function / Transplant, Kidney	1
2	Recruiting	Treatment	Epidermolysis Bullosa	1
2	Recruiting	Treatment	Focal Segmental Glomerulosclerosis (FSGS) / Transplantation, Kidney	1
2	Recruiting	Treatment	Graft Versus Host Disease (GVHD) / Hematopoietic/Lymphoid Cancer	1
2	Recruiting	Treatment	Graft Versus Host Disease (GVHD) / Neoplasms, Hematologic	1
2	Recruiting	Treatment	Haematological Malignancies	1
2	Recruiting	Treatment	Haplo-Cord Transplantation / Malignancies, Hematologic	1
2	Recruiting	Treatment	Hematopoietic Cell Transplantation Recipient / Non-Malignant / Non-Neoplastic Hematologic and Lymphocytic Disorder	1
2	Recruiting	Treatment	Hematopoietic and Lymphoid Cell Neoplasm	2
2	Recruiting	Treatment	Kidney Transplant Rejection	2
2	Recruiting	Treatment	Leukemia Acute Myeloid Leukemia (AML)	1
2	Recruiting	Treatment	Leukemia Acute Myeloid Leukemia (AML) / Myelodysplastic Syndromes	1
2	Recruiting	Treatment	Leukemia, Acute / Smith-Magenis Syndrome	1
2	Recruiting	Treatment	Liver Transplant Rejection	1
2	Recruiting	Treatment	Malignancies, Hematologic	1
2	Recruiting	Treatment	Orthotopic Liver Transplant	1
2	Recruiting	Treatment	Primary Myelofibrosis / Secondary Myelofibrosis	1
2	Recruiting	Treatment	Refractory and/or Relapsed Metastatic Solid Tumors	1
2	Recruiting	Treatment	Renal Transplant Infection	1
2	Recruiting	Treatment	Severe Aplastic Anemia (SAA)	1
2	Recruiting	Treatment	Sickle Cell Disorders	1
2	Recruiting	Treatment	Transplant, Kidney	1
2	Terminated	Prevention	Acute Leukemia in Remission / Leukemia, Myeloid, Accelerated-Phase / Leukemia, Myeloid, Chronic-Phase / Myelodysplastic Syndromes	1
2	Terminated	Prevention	Agnogenic Myeloid Metaplasia / Chronic Lymphocytic Leukaemia (CLL) / Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Follicular Lymphoma (FL) / Graft Versus Host Disease (GVHD) / Leukemia, Acute / Lymphoma, Large B-Cell, Diffuse (DLBCL) / Mantle Cell Lymphoma (MCL) / Marginal Zone Lymphoma (MZL) / Myelodysplastic Syndrome / Myeloproliferative Neoplasms / Small Lymphocytic Lymphoma	1
2	Terminated	Prevention	Cardiac Allograft Vasculopathy / Heart Transplant Recipients	1
2	Terminated	Prevention	Chronic Myeloid Leukemia (CML) / Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / Myelodysplastic Syndromes	1
2	Terminated	Prevention	Graft Versus Host Disease (GVHD)	1
2	Terminated	Prevention	Immunosuppression in Solid Organ Transplant	1
2	Terminated	Supportive Care	Chronic Myeloproliferative Disorders / Disorders, Lymphoproliferative / Graft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Neoplasms	1
2	Terminated	Treatment	Accelerated Phase Chronic Myelogenous Leukemia / Adult Acute Lymphoblastic Leukemia in Remission / Adult Acute Myeloid Leukemia in Remission / Adult Nasal Type Extranodal NK/T-Cell Lymphoma / Blastic Phase Chronic Myelogenous Leukemia / Chronic Lymphocytic Leukemia (CLL) - Refractory / Contiguous Stage II Adult Burkitt Lymphoma / Contiguous Stage II Adult Diffuse Large Cell Lymphoma / Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma / Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma / Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma / Contiguous Stage II Adult Lymphoblastic Lymphoma / Contiguous Stage II Grade 1 Follicular Lymphoma / Contiguous Stage II Grade 2 Follicular Lymphoma / Contiguous Stage II Grade 3 Follicular Lymphoma / Contiguous Stage II Mantle Cell Lymphoma / Contiguous Stage II Marginal Zone Lymphoma / Contiguous Stage II Small Lymphocytic Lymphoma / De Novo Myelodysplastic Syndromes / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Graft Versus Host Disease (GVHD) / Nodal marginal zone B-cell lymphomas / Noncontiguous Stage II Adult Burkitt Lymphoma / Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma / Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma / Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma / Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma / Noncontiguous Stage II Adult Lymphoblastic Lymphoma / Noncontiguous Stage II Grade 1 Follicular Lymphoma / Noncontiguous Stage II Grade 2 Follicular Lymphoma / Noncontiguous Stage II Grade 3 Follicular Lymphoma / Noncontiguous Stage II Mantle Cell Lymphoma / Noncontiguous Stage II Marginal Zone Lymphoma / Noncontiguous Stage II Small Lymphocytic Lymphoma / Previously Treated Myelodysplastic Syndromes / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Grade III Lymphomatoid Granulomatosis / Recurrent Adult Immunoblastic Large Cell Lymphoma / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Adult T-Cell Leukemia/Lymphoma / Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Mycosis Fungoides/Sezary Syndrome / Recurrent Small Lymphocytic Lymphoma / Relapsing Chronic Myelogenous Leukemia / Secondary Myelodysplastic Syndromes / Splenic Marginal Zone Lymphoma / Stage I Adult Burkitt Lymphoma / Stage I Adult Diffuse Large Cell Lymphoma / Stage I Adult Diffuse Mixed Cell Lymphoma / Stage I Adult Diffuse Small Cleaved Cell Lymphoma / Stage I Adult Immunoblastic Large Cell Lymphoma / Stage I Adult Lymphoblastic Lymphoma / Stage I Adult T-Cell Leukemia/Lymphoma / Stage I Chronic Lymphocytic Leukemia / Stage I Cutaneous T-cell Non-Hodgkin Lymphoma / Stage I Grade 1 Follicular Lymphoma / Stage I Grade 2 Follicular Lymphoma / Stage I Grade 3 Follicular Lymphoma / Stage I Mantle Cell Lymphoma / Stage I Marginal Zone Lymphoma / Stage I Mycosis Fungoides/Sezary Syndrome / Stage I Small Lymphocytic Lymphoma / Stage II Adult T-Cell Leukemia/Lymphoma / Stage II Chronic Lymphocytic Leukemia / Stage II Cutaneous T-cell Non-Hodgkin Lymphoma / Stage II Mycosis Fungoides/Sezary Syndrome / Stage III Adult Burkitt Lymphoma / Stage III Adult Diffuse Large Cell Lymphoma / Stage III Adult Diffuse Mixed Cell Lymphoma / Stage III Adult Diffuse Small Cleaved Cell Lymphoma / Stage III Adult Immunoblastic Large Cell Lymphoma / Stage III Adult Lymphoblastic Lymphoma / Stage III Adult T-Cell Leukemia/Lymphoma / Stage III Chronic Lymphocytic Leukemia / Stage III Cutaneous T-Cell Non-Hodgkin Lymphoma / Stage III Grade 1 Follicular Lymphoma / Stage III Grade 2 Follicular Lymphoma / Stage III Grade 3 Follicular Lymphoma / Stage III Mantle Cell Lymphoma / Stage III Marginal Zone Lymphoma / Stage III Mycosis Fungoides/Sezary Syndrome / Stage III Small Lymphocytic Lymphoma / Stage IV Adult Burkitt Lymphoma / Stage IV Adult Diffuse Large Cell Lymphoma / Stage IV Adult Diffuse Mixed Cell Lymphoma / Stage IV Adult Diffuse Small Cleaved Cell Lymphoma / Stage IV Adult Immunoblastic Large Cell Lymphoma / Stage IV Adult Lymphoblastic Lymphoma / Stage IV Adult T-Cell Leukemia/Lymphoma / Stage IV Chronic Lymphocytic Leukemia / Stage IV Cutaneous T-Cell Non-Hodgkin Lymphoma / Stage IV Grade 1 Follicular Lymphoma / Stage IV Grade 2 Follicular Lymphoma / Stage IV Grade 3 Follicular Lymphoma / Stage IV Mantle Cell Lymphoma / Stage IV Marginal Zone Lymphoma / Stage IV Mycosis Fungoides/Sezary Syndrome / Stage IV Small Lymphocytic Lymphoma / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Adult Acute Myeloid Leukemia / Waldenström's Macroglobulinemia (WM)	1
2	Terminated	Treatment	Acute Lymphoblastic Leukaemias (ALL) / Acute Myelocytic Leukemia / Chronic Myeloid Leukemia (CML) / Granulocytic Sarcoma / Hodgkin's or Non-Hodgkin's Lymphoma / Juvenile Myelomonocytic Leukemia / Myelodysplastic Syndrome	1
2	Terminated	Treatment	Acute Lymphoblastic Leukaemias (ALL) / All / Chronic Lymphocytic Leukaemia (CLL) / Leukemia Acute Myeloid Leukemia (AML) / Leukemias / Lymphoma, Hodgkins / Malignancies, Hematologic / Malignant Lymphomas / Non-Hodgkin's Lymphoma (NHL) / Plasma Cell Myeloma	1
2	Terminated	Treatment	Aplastic Anemia	1
2	Terminated	Treatment	Chronic Lymphocytic Leukaemia (CLL) / Lymphoma, B-Cell / Malignant Lymphomas / Non-Hodgkin's Lymphoma (NHL)	1
2	Terminated	Treatment	Chronic Myeloproliferative Disorders / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Neoplasms / Unusual Cancers of Childhood	1
2	Terminated	Treatment	End-Stage Renal Disease (ESRD)	1
2	Terminated	Treatment	Haematological Malignancies	1
2	Terminated	Treatment	Haemoglobinopathies congenital / Hemoglobin SC Disease / Sickle Cell Anemia / Thalassaemic disorders / Thalassemia Major (TM)	1
2	Terminated	Treatment	Haemoglobinopathies congenital / Sickle Cell Anemia / Thalassaemic disorders	1
2	Terminated	Treatment	Hepatitis, Autoimmune	1
2	Terminated	Treatment	Kidney Transplantation (Status Post)	1
2	Terminated	Treatment	Leukemias	1
2	Terminated	Treatment	Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myeloproliferative Disorders	1
2	Terminated	Treatment	Leukemias / Malignant Lymphomas / Myelodysplastic Syndrome	1
2	Terminated	Treatment	Leukemias / Malignant Lymphomas / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases	1
2	Terminated	Treatment	Leukemias / Malignant Lymphomas / Myeloproliferative Disorders / Plasma Cell Myeloma	1
2	Terminated	Treatment	Malignant Lymphomas	1
2	Terminated	Treatment	Neoplasms, Malignant	1
2	Terminated	Treatment	New Onset Diabetes Mellitus After Renal Transplantation	1
2	Terminated	Treatment	Primary Renal Allograft Candidate / Transplantation, Kidney	1
2	Terminated	Treatment	Primary Simultaneous Kidney and Pancreas Allograft Candidates / Simultaneous Kidney and Pancreas Transplantation	1
2	Terminated	Treatment	Refractory Multiple Myeloma / Stage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma	1
2	Terminated	Treatment	Renal Transplant Recipient Patients	1
2	Terminated	Treatment	Sickle Cell Disorders	1
2	Terminated	Treatment	Transplantation, Kidney	1
2	Terminated	Treatment	Transplantation, Kidney / Transplantation, Renal	1
2	Unknown Status	Treatment	Acute Lymphocytic Leukemia (ALL) / Leukemia Acute Myeloid Leukemia (AML) / Malignant Lymphomas / Multiple Myeloma (MM) / Myelodysplastic Syndrome	1
2	Unknown Status	Treatment	Chronic Myeloproliferative Disorders / Leukemias / Malignant Lymphomas / Multiple Myeloma and Malignant Plasma Cell Neoplasms / Myelodysplastic Syndromes / Precancerous/Nonmalignant Condition / Secondary Myelofibrosis	1
2	Unknown Status	Treatment	Conjunctivitis, Seasonal Allergic	1
2	Unknown Status	Treatment	Disseminated Sclerosis	1
2	Unknown Status	Treatment	Kidney Diseases	1
2	Unknown Status	Treatment	Nephritis, Lupus	1
2	Withdrawn	Supportive Care	Graft Versus Host Disease (GVHD) / Leukemias	1
2	Withdrawn	Treatment	Accelerated Phase Chronic Myelogenous Leukemia / Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome / Adult Acute Lymphoblastic Leukemia in Remission / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Adult Nasal Type Extranodal NK/T-Cell Lymphoma / Anaplastic Large Cell Lymphoma / Angioimmunoblastic T-Cell Lymphoma / Blastic Phase Chronic Myelogenous Leukemia / Chronic Lymphocytic Leukemia (CLL) - Refractory / Cutaneous B-Cell Non-Hodgkin Lymphoma / De Novo Myelodysplastic Syndromes / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Hepatosplenic T-Cell Lymphoma / Intraocular Lymphoma / Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable / Nodal marginal zone B-cell lymphomas / Noncutaneous Extranodal Lymphoma / Peripheral T-Cell Lymphoma (PTCL) / Post Transplant Lymphoproliferative Disorder / Previously Treated Myelodysplastic Syndromes / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Grade III Lymphomatoid Granulomatosis / Recurrent Adult Hodgkin's Lymphoma / Recurrent Adult Immunoblastic Large Cell Lymphoma / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Adult T-Cell Leukemia/Lymphoma / Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Mycosis Fungoides/Sezary Syndrome / Recurrent Small Lymphocytic Lymphoma / Refractory Hairy Cell Leukemia / Refractory Multiple Myeloma / Relapsing Chronic Myelogenous Leukemia / Secondary Acute Myeloid Leukemia (Secondary AML, sAML) / Secondary Myelodysplastic Syndromes / Small Intestine Lymphoma / Splenic Marginal Zone Lymphoma / T-Cell Large Granular Lymphocyte Leukemia / Testicular Lymphoma / Waldenström's Macroglobulinemia (WM)	1
2	Withdrawn	Treatment	Age-Related Macular Degeneration (ARMD)	1
2	Withdrawn	Treatment	Anemias / Chronic Myeloproliferative Disorders / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases	1
2	Withdrawn	Treatment	Colitis / Cytokines / Drug Evaluation / Hermanski-Pudlak Syndrome / Lymphocytes	1
2	Withdrawn	Treatment	Crohn's Disease (CD)	1
2	Withdrawn	Treatment	Fibrolamellar Hepatocellular Carcinoma / Hepatocellular Carcinoma (Fibrolamellar Variant) / Hepatocellular,Carcinoma	1
2	Withdrawn	Treatment	Neuroblastomas	1
2	Withdrawn	Treatment	Renal Cancers	1
2	Withdrawn	Treatment	Scleroderma, Systemic	1
2	Withdrawn	Treatment	Type 1 Diabetes Mellitus	1
2, 3	Active Not Recruiting	Treatment	Transplantation, Kidney	1
2, 3	Completed	Prevention	Graft Versus Host Disease (GVHD)	1
2, 3	Completed	Treatment	Chronic Graft Versus Host Disease	1
2, 3	Completed	Treatment	Dermatomyositis / Pneumonitis, Interstitial / Polymyositis	1
2, 3	Completed	Treatment	Graft Versus Host Disease (GVHD) / Leukemias / Myelodysplastic Syndromes	1
2, 3	Completed	Treatment	Idiopathic Membranous Nephropathy / Nephrotic Syndrome	1
2, 3	Completed	Treatment	Maintenance With Tacrolimus / Pediatric Patients / Transplantation, Kidney	1
2, 3	Completed	Treatment	Nephrotic Syndrome	1
2, 3	Completed	Treatment	Vernal Keratoconjunctivitis	1
2, 3	Not Yet Recruiting	Treatment	Transplantation, Liver	1
2, 3	Recruiting	Prevention	Keratopathy	1
2, 3	Recruiting	Prevention	Post Liver Transplant	1
2, 3	Recruiting	Prevention	Face edema	1
2, 3	Recruiting	Treatment	Amputation, Traumatic/Surgery / Amputations / Penis/Injuries / Penis/Surgery / Penis/Transplantation / Traumatic Amputations / Urologic Surgical Procedures, Male / Wounds and Injuries	1
2, 3	Recruiting	Treatment	End Stage Renal Disease (ESRD)	1
2, 3	Recruiting	Treatment	Kidney Pancreas Transplantation	1
2, 3	Terminated	Prevention	Penetrating Keratoplasty	1
2, 3	Terminated	Treatment	Delayed Graft Function	1
2, 3	Terminated	Treatment	Follicular Lymphoma (FL) / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma	1
2, 3	Terminated	Treatment	Graft Failure / Ischemia Reperfusion Injury / Poor Graft Quality / Terminal Liver Disease / Transplant dysfunction	1
2, 3	Terminated	Treatment	Graft Versus Host Disease (GVHD)	1
2, 3	Terminated	Treatment	High Blood Pressure (Hypertension)	1
2, 3	Terminated	Treatment	Pigmentation Disorders / Vitiligo	1
2, 3	Unknown Status	Treatment	Rasmussen's Encephalitis	1
2, 3	Withdrawn	Treatment	Prostate Cancer	1
3	Active Not Recruiting	Prevention	Leukemia, Acute / Myelodysplasia	1
3	Active Not Recruiting	Treatment	B-cell Childhood Acute Lymphoblastic Leukemia / Childhood Acute Lymphoblastic Leukemia in Remission / Graft Versus Host Disease (GVHD) / L1 Childhood Acute Lymphoblastic Leukemia / L2 Childhood Acute Lymphoblastic Leukemia / T-cell Childhood Acute Lymphoblastic Leukemia	1
3	Active Not Recruiting	Treatment	Chronic Kidney Disease (CKD)	1
3	Active Not Recruiting	Treatment	Disorder Related to Bone Marrow Transplantation / Leukemias / Transplantation Infection	1
3	Active Not Recruiting	Treatment	Impaired kidney function / Kidney Diseases / Renal Failure / Renal Insufficiency,Chronic	1
3	Active Not Recruiting	Treatment	Transplantation, Kidney	1
3	Active Not Recruiting	Treatment	Type 1 Diabetes Mellitus	1
3	Completed	Not Available	Pharmacokinetics / Tacrolimus	1
3	Completed	Not Available	Transplantation, Liver	1
3	Completed	Basic Science	Renal Failure	1
3	Completed	Prevention	Bronchiolitis Obliterans (BO) / Immunosuppression	1
3	Completed	Prevention	Chronic Renal Failure (CRF)	1
3	Completed	Prevention	Graft Versus Host Disease (GVHD) / Survival	1
3	Completed	Prevention	Renal Failure	1
3	Completed	Prevention	Transplantation, Kidney	6
3	Completed	Prevention	Transplantation, Liver	3
3	Completed	Supportive Care	Graft Versus Host Disease (GVHD)	1
3	Completed	Treatment	Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome / Acute Myeloid Leukemia/Transient Myeloproliferative Disorder / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Childhood Acute Myeloid Leukemia in Remission / Childhood Myelodysplastic Syndromes / De Novo Myelodysplastic Syndromes / Myelodysplastic Syndrome With Isolated Del(5q) / Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable / Previously Treated Myelodysplastic Syndromes / Recurrent Adult Acute Myeloid Leukemia / Recurrent Childhood Acute Myeloid Leukemia / Secondary Acute Myeloid Leukemia (Secondary AML, sAML) / Secondary Myelodysplastic Syndromes	1
3	Completed	Treatment	Atopic Dermatitis (AD)	9
3	Completed	Treatment	Chronic Myeloid Leukemia (CML) / Leukemia, Lymphocytic, Acute / Leukemia, Myelocytic, Acute / Myelodysplastic Syndromes	1
3	Completed	Treatment	Conjunctivitis / Keratoconjunctivitis	2
3	Completed	Treatment	Dry Eye / Sjögren's Syndrome	1
3	Completed	Treatment	Failing Renal Allograft / Transplant, Kidney	1
3	Completed	Treatment	Glomerulonephritis membranous	1
3	Completed	Treatment	Glomerulonephritis, Membranous / Nephritis, Lupus	1
3	Completed	Treatment	Heart Diseases / Heart Transplantation	1
3	Completed	Treatment	Heart Transplantation / Transplantation, Kidney / Transplantation, Liver	1
3	Completed	Treatment	Hepatitis C Viral Infection / Liver Cirrhosis	1
3	Completed	Treatment	Hepatocellular,Carcinoma	1
3	Completed	Treatment	Host vs Graft Reaction / Transplantation Immunology / Transplantation, Kidney	1
3	Completed	Treatment	Host vs Graft Reaction / Transplantation Immunology / Transplantation, Liver	1
3	Completed	Treatment	Induction Phase / Kidney Diseases / Maintenance Phase / Nephritis, Lupus / Tacrolimus	1
3	Completed	Treatment	Kidney Diseases	2
3	Completed	Treatment	Kidney Diseases / Nephrotic Syndrome / Tacrolimus	1
3	Completed	Treatment	Kidney-Pancreas Transplantation	1
3	Completed	Treatment	Liver Transplanted Patients	1
3	Completed	Treatment	Lymphoma, Hodgkins / Non-Hodgkin's Lymphoma (NHL)	1
3	Completed	Treatment	Myasthenia Gravis	3
3	Completed	Treatment	Nephritis, Lupus	3
3	Completed	Treatment	Nephrotic Syndrome	2
3	Completed	Treatment	Psoriasis	3
3	Completed	Treatment	Rejection, Transplant / Renal Failure / Transplantation, Kidney	1
3	Completed	Treatment	Renal Failure	2
3	Completed	Treatment	Renal Failure / Tremor	1
3	Completed	Treatment	Renal Function / Transplantation, Liver	1
3	Completed	Treatment	Rheumatoid Arthritis	2
3	Completed	Treatment	Skin Cancers / Transplantation, Kidney	1
3	Completed	Treatment	Transplant, Kidney	2
3	Completed	Treatment	Transplant; Failure, Kidney	1
3	Completed	Treatment	Transplantation, Kidney	6
3	Completed	Treatment	Transplantation, Liver	9
3	Completed	Treatment	Transplantation, Renal	2
3	Completed	Treatment	Transplantations	3
3	Completed	Treatment	Type 1 Diabetes Mellitus	1
3	Completed	Treatment	Ulcerative Colitis	2
3	Completed	Treatment	Vitiligo	1
3	Not Yet Recruiting	Prevention	Transplantation, Liver	1
3	Not Yet Recruiting	Treatment	Acute Lymphoblastic Leukaemias (ALL) / Graft Versus Host Disease, Acute / Hematopoietic Stem Cell Transplantation (HSCT) / Leukemia Acute Myeloid Leukemia (AML) / Myelodysplastic Syndromes	1
3	Not Yet Recruiting	Treatment	Antisynthetase Syndrome (ASS) / Interstitial Lung Diseases (ILD)	1
3	Not Yet Recruiting	Treatment	Medication Adherence	1
3	Recruiting	Prevention	Acute Lymphocytic Leukemia (ALL) / Leukemia Acute Myeloid Leukemia (AML) / Myelodysplastic Syndrome	1
3	Recruiting	Prevention	Chronic Chronic myelogenous leukemia / CML / Leukemia, Acute / Malignant Lymphomas / Myelodysplasia	1
3	Recruiting	Prevention	Renal Failure	2
3	Recruiting	Supportive Care	Acute Biphenotypic Leukemia (ABL) / Acute Lymphoblastic Leukaemias (ALL) / Chronic Chronic myelogenous leukemia / Chronic Lymphocytic Leukaemia (CLL) / Hodgkins Disease (HD) / Leukemia Acute Myeloid Leukemia (AML) / Multiple Myeloma (MM) / Myelodysplastic Syndrome / Myeloproliferative Neoplasms / Non-Hodgkin's Lymphoma (NHL)	1
3	Recruiting	Treatment	Absolute Uterine Factor Infertility / Female Infertility / Mayer Rokitansky Kuster Hauser Syndrome / Mullerian Aplasia / Uterus Absence, Acquired / Uterus; Absence, Congenital	1
3	Recruiting	Treatment	Agnogenic Myeloid Metaplasia / Chronic Lymphocytic Leukaemia (CLL) / Chronic Myeloid Leukemia (CML) / Leukemia Acute Myeloid Leukemia (AML) / Malignant Lymphomas / Myelodysplasia / Myeloproliferative Disorders / Non-Hodgkin's Lymphoma (NHL) / Plasma Cell Dyscrasia	1
3	Recruiting	Treatment	Atopic Dermatitis (AD)	1
3	Recruiting	Treatment	Cardiac Allograft Vasculopathy / Chronic Kidney Disease (CKD) / Heart Transplant Failure and Rejection / Heart Transplant Infection / Immunosuppression / Pediatric Heart Transplantation / Post Transplant Lymphoproliferative Disorder	1
3	Recruiting	Treatment	End Stage Renal Disease (ESRD) / Rejection of Renal Transplant	1
3	Recruiting	Treatment	Graft Versus Host Disease (GVHD)	1
3	Recruiting	Treatment	Severe Seborrheic Dermatitis	1
3	Recruiting	Treatment	Uveitis	1
3	Recruiting	Treatment	Vitiligo	1
3	Suspended	Treatment	Transplant, Kidney	1
3	Terminated	Prevention	Evidence of Liver Transplantation	1
3	Terminated	Prevention	Transplantation, Lung	1
3	Terminated	Treatment	Atherosclerosis / Renal Failure	1
3	Terminated	Treatment	End-Stage Renal Disease (ESRD) / Transplantation, Kidney	1
3	Terminated	Treatment	Function of Renal Transplant	1
3	Terminated	Treatment	Nephritis, Lupus	1
3	Terminated	Treatment	Transplantation, Liver	1
3	Terminated	Treatment	Ulcerative Colitis	1
3	Withdrawn	Prevention	Transplantation, Renal	1
3	Withdrawn	Treatment	Nephritis, Lupus	1
4	Active Not Recruiting	Health Services Research	Transplantation, Liver	1
4	Active Not Recruiting	Prevention	End-Stage Renal Disease (ESRD)	1
4	Active Not Recruiting	Treatment	Cytomegalovirus / Transplantation, Kidney	1
4	Active Not Recruiting	Treatment	Function of Renal Transplant	1
4	Active Not Recruiting	Treatment	Hepatocellular,Carcinoma	1
4	Active Not Recruiting	Treatment	Kidney Transplant Rejection / Other Complications of Kidney Transplant	1
4	Active Not Recruiting	Treatment	Liver Diseases	1
4	Active Not Recruiting	Treatment	Pancreas Transplantation / Transplantation, Kidney	1
4	Active Not Recruiting	Treatment	Renal Transplant Patients	1
4	Active Not Recruiting	Treatment	Transplant, Kidney	1
4	Active Not Recruiting	Treatment	Transplantation, Renal	1
4	Completed	Not Available	Atopic Dermatitis (AD)	1
4	Completed	Not Available	End Stage Renal Disease (ESRD)	1
4	Completed	Not Available	Function of Renal Transplant	1
4	Completed	Basic Science	End Stage Renal Disease (ESRD)	1
4	Completed	Basic Science	Pharmacokinetics Study in de Novo Kidney Transplantation	1
4	Completed	Basic Science	Transplantation, Kidney	1
4	Completed	Diagnostic	Cardiac Transplant	1
4	Completed	Health Services Research	Chronic Renal Failure (CRF)	1
4	Completed	Other	Kidney / Pharmacokinetics / Transplantations	1
4	Completed	Other	Transplantation, Kidney / Transplantation, Liver	1
4	Completed	Prevention	Disorder Related to Cardiac Transplantation	1
4	Completed	Prevention	Disorder Related to Renal Transplantation	1
4	Completed	Prevention	Erectile Dysfunction / Prostate Cancer	1
4	Completed	Prevention	Heart Transplantation / Transplantation, Kidney / Transplantation, Liver	1
4	Completed	Prevention	Infections, Cytomegalovirus / Transplantation Infection	1
4	Completed	Prevention	Kidney Transplantion / Renal Transplantion	1
4	Completed	Prevention	Post Transplant Diabetes Mellitus	1
4	Completed	Prevention	Rejection, Transplant / Renal Allograft Recipients / Transplant, Kidney	1
4	Completed	Prevention	Rejection, Transplant / Renal Failure	1
4	Completed	Prevention	Rejection, Transplant / Transplantation, Kidney	1
4	Completed	Prevention	Skin Neoplasms / Transplantation, Kidney	1
4	Completed	Prevention	Transplant, Kidney	1
4	Completed	Prevention	Transplantation, Kidney	3
4	Completed	Prevention	Transplantation, Liver	1
4	Completed	Prevention	Transplantation, Renal	2
4	Completed	Screening	Transplantation, Liver	1
4	Completed	Supportive Care	Cardiovascular Heart Disease / Immunosuppression / Transplantation, Kidney	1
4	Completed	Supportive Care	Hepatitis C Viral Infection / Renal Allograft	1
4	Completed	Supportive Care	Kidney Diseases / Transplant, Kidney	1
4	Completed	Treatment	Adult Primary Kidney Transplantation	1
4	Completed	Treatment	Atopic Dermatitis (AD)	9
4	Completed	Treatment	Bone Marrow Transplant (BMT) / Hematopoietic Stem Cell Transplant (HSCT) / Immunosuppression	1
4	Completed	Treatment	Chronic Kidney Disease (CKD) / End Stage Renal Disease (ESRD) / Hemodialysis Treatment / Renal Replacement Therapies / Transplantation, Renal	1
4	Completed	Treatment	Chronic Renal Allograft Failure / Transplantation, Renal	1
4	Completed	Treatment	Chronic Renal Diseases	1
4	Completed	Treatment	Chronic Renal Failure (CRF)	1
4	Completed	Treatment	Chronic Renal Failure (CRF) / Renal Insufficiency,Chronic / Transplantation, Kidney	1
4	Completed	Treatment	Complication of Transplant	1
4	Completed	Treatment	Complications of Transplanted Organs and Tissue / Diabetes Mellitus Nos New Onset	1
4	Completed	Treatment	De Novo Kidney Transplantation	1
4	Completed	Treatment	Diabetic Nephropathies / Transplant, Kidney / Type 2 Diabetes Mellitus	1
4	Completed	Treatment	Disorder Related to Renal Transplantation	1
4	Completed	Treatment	Disorder Related to Renal Transplantation / Infections, Cytomegalovirus	1
4	Completed	Treatment	Drug Interaction Potentiation / Transplantation, Kidney	1
4	Completed	Treatment	Dry Eye Syndrome (DES) / Sjögren's Syndrome	1
4	Completed	Treatment	End Stage Liver Diseases / Hepatitis C Viral Infection / Transplantation, Liver	1
4	Completed	Treatment	End Stage Renal Disease (ESRD)	2
4	Completed	Treatment	End-Stage Renal Disease (ESRD)	1
4	Completed	Treatment	Glomerulonephritis, Membranous / Nephrotic Syndrome Secondary to Idiopathic Membranous Glomerulonephritis	1
4	Completed	Treatment	Graft Versus Host Disease (GVHD)	1
4	Completed	Treatment	Graft Versus Host Disease (GVHD) / Renal Failure	1
4	Completed	Treatment	Heart Transplantation	1
4	Completed	Treatment	Henoch-Schoenlein Purpura Nephritis	1
4	Completed	Treatment	Hepatic Failure	1
4	Completed	Treatment	Hepatitis C Viral Infection	1
4	Completed	Treatment	Hepatitis C Viral Infection / Transplantation, Liver	1
4	Completed	Treatment	Immunosuppression	2
4	Completed	Treatment	Immunosuppression After Liver Transplantation	1
4	Completed	Treatment	Immunosuppression / Renal Failure	1
4	Completed	Treatment	Implant or Graft; Rejection	1
4	Completed	Treatment	Infections, Cytomegalovirus / Renal Transplant Failure / Transplant; Complication, Rejection	1
4	Completed	Treatment	Interstitial Fibrosis (IF) / Transplant dysfunction	1
4	Completed	Treatment	Ischemia Reperfusion Injury	1
4	Completed	Treatment	Kidney Diseases	1
4	Completed	Treatment	Kidney Pancreas Transplant / Transplant, Kidney	1
4	Completed	Treatment	Kidney Transplant Patients	1
4	Completed	Treatment	Kidney Transplant Rejection	1
4	Completed	Treatment	Kidney Transplantation, Renal Transplantation	1
4	Completed	Treatment	Liver Cirrhosis / Liver Transplant Disorder	1
4	Completed	Treatment	Liver Transplanted Patients / Renal Transplant Recipient Patients	1
4	Completed	Treatment	MCNS / Minimal Change Nephrotic Syndrome (MCNS)	1
4	Completed	Treatment	Moderate/Severe Atopic Dermatitis	1
4	Completed	Treatment	Nephritis, Lupus	3
4	Completed	Treatment	Nephritis, Lupus / Systemic Lupus Erythematosus (SLE)	1
4	Completed	Treatment	Nephrotic Syndrome	3
4	Completed	Treatment	Organ or Tissue Transplant; Complications	1
4	Completed	Treatment	Pityriasis Alba	1
4	Completed	Treatment	Polyomavirus Infections	1
4	Completed	Treatment	Rejection, Transplant / Renal Failure / Transplantation, Kidney	1
4	Completed	Treatment	Renal Transplant Recipient Patients	1
4	Completed	Treatment	Rheumatoid Arthritis	5
4	Completed	Treatment	Seborrheic Dermatitis	1
4	Completed	Treatment	Skin Inflammation	1
4	Completed	Treatment	Stable Renal Recipients / Transplantation, Kidney / Transplantation, Renal	1
4	Completed	Treatment	Transplant, Kidney	4
4	Completed	Treatment	Transplantation, Kidney	15
4	Completed	Treatment	Transplantation, Kidney / Transplantation, Liver	1
4	Completed	Treatment	Transplantation, Kidney / Transplantations	1
4	Completed	Treatment	Impaired kidney function / Transplantation, Kidney	1
4	Completed	Treatment	Transplantation, Liver	9
4	Completed	Treatment	Transplantation, Renal	5
4	Completed	Treatment	Ulcerative Colitis	1
4	Completed	Treatment	Uveitis	1
4	Completed	Treatment	Vernal Keratoconjunctivitis	1
4	Completed	Treatment	De Novo Liver Transplant Subjects	1
4	Enrolling by Invitation	Treatment	Grafting, Kidney / Transplantation, Kidney / Transplantation, Renal	1
4	Enrolling by Invitation	Treatment	Transplant, Kidney	2
4	Enrolling by Invitation	Treatment	Transplantation, Liver	1
4	Not Yet Recruiting	Supportive Care	Transplant; Failure, Kidney	1
4	Not Yet Recruiting	Treatment	Disorder Related to Renal Transplantation / Immunosuppression Related Infectious Disease / Virus Diseases	1
4	Not Yet Recruiting	Treatment	Immunosuppression After Renal Transplantation / Transplant, Kidney	1
4	Not Yet Recruiting	Treatment	Kidney Transplant Failure and Rejection	1
4	Not Yet Recruiting	Treatment	Liver Transplant; Complications / Neurologic toxicity	1
4	Recruiting	Basic Science	Immunosuppression / Kidney Transplant; Complications	1
4	Recruiting	Diagnostic	Chronic Renal Failure (CRF)	1
4	Recruiting	Health Services Research	Dry Eye Syndromes / Inflammatory Reaction / Microvessels	1
4	Recruiting	Other	Atopic Dermatitis (AD)	1
4	Recruiting	Other	Transplantation, Liver	1
4	Recruiting	Prevention	Allosensitization / Immunosuppression / Kidney Transplant Failure	1
4	Recruiting	Prevention	Kidney Transplant Failure and Rejection / Kidney Transplant Rejection	1
4	Recruiting	Prevention	Kidney Transplant Infection	1
4	Recruiting	Prevention	Transplant, Kidney	1
4	Recruiting	Supportive Care	Renal Transplant Recipient Patients	1
4	Recruiting	Treatment	Adherence to Medication Regime	1
4	Recruiting	Treatment	Allograft	1
4	Recruiting	Treatment	Autoimmune Hemolytic Anemia / Evans Syndrome / Pure Red Cell Aplasia	1
4	Recruiting	Treatment	Cardiac Transplant Rejection / Kidney Transplant Rejection / Liver Transplant Rejection	1
4	Recruiting	Treatment	Cyclosporine/Tacrolimus	1
4	Recruiting	Treatment	Delayed Graft Function	1
4	Recruiting	Treatment	EBV / Transplant; Failure, Kidney	1
4	Recruiting	Treatment	Elderly Patients / Immunosuppression / Renal Transplant Recipient Patients	1
4	Recruiting	Treatment	End Stage Renal Disease (ESRD)	1
4	Recruiting	Treatment	Fibrillary Glomerulopathy / Kidney Diseases	1
4	Recruiting	Treatment	Heart Failure	1
4	Recruiting	Treatment	Hepatitis B Virus Associated Nephrotic Syndrome	1
4	Recruiting	Treatment	Immunosuppression / Transplantation, Kidney	1
4	Recruiting	Treatment	Kidney Transplant Patients	1
4	Recruiting	Treatment	Kidney Transplant Rejection	1
4	Recruiting	Treatment	Kidney Transplant; Complications	2
4	Recruiting	Treatment	Kidney Transplant; Complications / Neurologic toxicity / Therapeutic Agent Toxicity	1
4	Recruiting	Treatment	Left Ventricular Hypertrophy	1
4	Recruiting	Treatment	Liver Dysfunction	1
4	Recruiting	Treatment	Nephritis, Lupus	1
4	Recruiting	Treatment	Nephrotic Syndrome	1
4	Recruiting	Treatment	Rheumatoid Arthritis	2
4	Recruiting	Treatment	Tacrolimus, Kaposiform Hemangioendothelioma, Tufted Angioma	1
4	Recruiting	Treatment	Thalassemia Major (TM)	2
4	Recruiting	Treatment	Transplant, Kidney	3
4	Recruiting	Treatment	Transplantation, Kidney	1
4	Recruiting	Treatment	Transplantation, Liver	1
4	Recruiting	Treatment	Vernal Keratoconjunctivitis	1
4	Recruiting	Treatment	Vitiligo	1
4	Terminated	Prevention	Diabetes Mellitus, Adult-Onset	1
4	Terminated	Prevention	Heart Transplantation / Transplantation, Kidney / Transplantation, Liver	1
4	Terminated	Prevention	Hepatitis C Viral Infection / Transplantation, Liver	1
4	Terminated	Prevention	Skin Cancers / Transplantation, Kidney	1
4	Terminated	Prevention	Transplantation, Renal	1
4	Terminated	Prevention	Impaired kidney function	1
4	Terminated	Treatment	Delayed Graft Function / Slow Graft Function-defined at Creatinine >= 3.0 by Post-op Day 5 Without Requiring Dialysis / Transplant, Kidney	1
4	Terminated	Treatment	Diabetes Mellitus	1
4	Terminated	Treatment	Immunosuppression	1
4	Terminated	Treatment	Kidney Transplant Failure and Rejection	1
4	Terminated	Treatment	Kidney Transplant Rejection	1
4	Terminated	Treatment	Lung and Heart-lung Transplantation	1
4	Terminated	Treatment	Nephritis, Lupus	1
4	Terminated	Treatment	Renal Transplant Recipient Patients	1
4	Terminated	Treatment	Transplantation, Kidney	3
4	Terminated	Treatment	Transplants and Implants	1
4	Unknown Status	Not Available	New Onset Diabetes After Transplant / Transplantation, Kidney	1
4	Unknown Status	Prevention	Disorder Related to Renal Transplantation	1
4	Unknown Status	Prevention	End-stage Renal Failure (ESRF) / Rejection, Transplant	1
4	Unknown Status	Prevention	Immunosuppression / Transplantation, Kidney / Transplantations	2
4	Unknown Status	Prevention	Kidney; Complications, Allograft	1
4	Unknown Status	Prevention	Renal Transplant Recipient Patients	1
4	Unknown Status	Prevention	Transplantation, Kidney	1
4	Unknown Status	Treatment	Chronic Hepatitis C Virus (HCV) Infection / Transplantation, Renal	1
4	Unknown Status	Treatment	De Novo Transplant Disease	2
4	Unknown Status	Treatment	Dermatitis, Contact / Dermatitis, Occupational	1
4	Unknown Status	Treatment	Hepatitis	1
4	Unknown Status	Treatment	Immunosuppression / Liver Diseases / Transplantation, Liver	1
4	Unknown Status	Treatment	Immunosuppression / Transplant, Kidney	1
4	Unknown Status	Treatment	Infections, Cytomegalovirus	1
4	Unknown Status	Treatment	Kidney Diseases	2
4	Unknown Status	Treatment	Kidney Diseases / Rejection, Transplant	1
4	Unknown Status	Treatment	Pediatric Liver Transplantation	1
4	Unknown Status	Treatment	Transplantation, Kidney	4
4	Unknown Status	Treatment	Vitiligo	2
4	Withdrawn	Not Available	Plasmapheresis / Transplantation, Kidney	1
4	Withdrawn	Not Available	Transplantation, Kidney	1
4	Withdrawn	Treatment	Acute Cellular Graft Rejection / Liver Transplant Rejection	1
4	Withdrawn	Treatment	Antibody Mediated Rejection / End Stage Renal Disease (ESRD)	1
4	Withdrawn	Treatment	Atopic Dermatitis (AD)	1
4	Withdrawn	Treatment	Kidney Graft Dysfunction	1
4	Withdrawn	Treatment	Living Donor Kidney Transplants Patients	1
Not Available	Active Not Recruiting	Not Available	Interstitial Pneumonia Associated With Polymyositis/Dermatomyositis	1
Not Available	Active Not Recruiting	Not Available	Nephritis, Lupus	1
Not Available	Active Not Recruiting	Not Available	Nephrotic Syndrome	1
Not Available	Active Not Recruiting	Not Available	Transplantation, Kidney	1
Not Available	Active Not Recruiting	Treatment	Allografts / Transplantation, Lung	1
Not Available	Active Not Recruiting	Treatment	End Stage Renal Failure With Renal Transplant	1
Not Available	Active Not Recruiting	Treatment	End-Stage Renal Disease (ESRD)	1
Not Available	Approved for Marketing	Not Available	Renal Failure	1
Not Available	Available	Not Available	Athymia / Immunodeficiencies / Immunoreconstitution / Low T Cell Numbers / Poor Thymic Function / Thymus Transplantation	1
Not Available	Available	Not Available	Complete DiGeorge Anomaly / Complete DiGeorge Syndrome / DiGeorge Anomaly / DiGeorge's syndrome	1
Not Available	Completed	Not Available	Acute Graft Rejection / Chronic Allograft Nephropathy (CAN) / Polyomavirus-related Transplant Nephropathy	1
Not Available	Completed	Not Available	Delirium / Prolonged QT Interval	1
Not Available	Completed	Not Available	Healthy Volunteers	4
Not Available	Completed	Not Available	Hemochromatosis	1
Not Available	Completed	Not Available	Islet Transplantation / Type 1 Diabetes Mellitus	1
Not Available	Completed	Not Available	Pediatric Heart Transplant Recipients / Pediatric Heart Transplantation	1
Not Available	Completed	Not Available	Rheumatoid Arthritis	1
Not Available	Completed	Not Available	Transplant, Kidney / Transplantation, Liver	1
Not Available	Completed	Not Available	Transplantation, Liver	2
Not Available	Completed	Not Available	Transplantation, Renal	2
Not Available	Completed	Not Available	The Maintenance Phase After Kidney Transplantation	1
Not Available	Completed	Prevention	Absence; Kidney	1
Not Available	Completed	Prevention	BK Nephropathy / BK Viremia	1
Not Available	Completed	Prevention	Early Allograft Dysfunction / Hyperfibrinolysis / Ischemic Reperfusion Injury / Transplantation, Liver	1
Not Available	Completed	Prevention	Immunosuppression / Renal Failure	1
Not Available	Completed	Prevention	Transplantation, Liver	1
Not Available	Completed	Screening	Chronic Renal Failure (CRF)	1
Not Available	Completed	Screening	Transplantation, Kidney	1
Not Available	Completed	Supportive Care	Chronic Myeloproliferative Disorders / Graft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Neoplasms	1
Not Available	Completed	Treatment	Acute Graft Rejection / Diabetes	1
Not Available	Completed	Treatment	Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Childhood Acute Myeloid Leukemia in Remission / Childhood Myelodysplastic Syndromes / De Novo Myelodysplastic Syndromes / Essential Thrombocythemia (ET) / Myelodysplastic Syndrome With Isolated Del(5q) / Polycythemia Vera (PV) / Previously Treated Myelodysplastic Syndromes / Primary Myelofibrosis / Recurrent Adult Acute Myeloid Leukemia / Recurrent Childhood Acute Myeloid Leukemia / Secondary Acute Myeloid Leukemia (Secondary AML, sAML) / Secondary Myelodysplastic Syndromes / Secondary Myelofibrosis / Untreated Adult Acute Myeloid Leukemia / Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies	1
Not Available	Completed	Treatment	Blood and Marrow Transplant (BMT) / Graft Versus Host Disease (GVHD)	1
Not Available	Completed	Treatment	Chronic Allograft Nephropathy (CAN) / Transplantation, Kidney	1
Not Available	Completed	Treatment	Chronic Myeloproliferative Disorders / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes	1
Not Available	Completed	Treatment	Dermatologic Disease / Vitiligo	1
Not Available	Completed	Treatment	Effects of Immunosuppressant Therapy / Evidence of Liver Transplantation	1
Not Available	Completed	Treatment	Graft Versus Host Disease (GVHD) / Mucositis	1
Not Available	Completed	Treatment	Idiopathic Membranous Nephropathy	2
Not Available	Completed	Treatment	Immunosuppression	2
Not Available	Completed	Treatment	Living Donors / Transplantation, Kidney	1
Not Available	Completed	Treatment	Malignant Lymphomas	1
Not Available	Completed	Treatment	Moderate to Severe Atopic Dermatitis	1
Not Available	Completed	Treatment	Nephritis, Lupus	5
Not Available	Completed	Treatment	Paraneoplastic Syndromes	1
Not Available	Completed	Treatment	Psoriasis Vulgaris (Plaque Psoriasis)	1
Not Available	Completed	Treatment	Stable Vitiligo	1
Not Available	Completed	Treatment	Transplant, Kidney	1
Not Available	Completed	Treatment	Transplantation, Kidney	2
Not Available	No Longer Available	Not Available	Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Precancerous Conditions / Secondary Myelofibrosis	1
Not Available	No Longer Available	Not Available	Type 1 Diabetes Mellitus	2
Not Available	Not Yet Recruiting	Not Available	Acute Rejection of Renal Transplant / Biopsy Proven Acute Rejection (BPAR) / Bone Diseases / Cardiovascular Risk / Death / Graft Failure / HLA Antibody Production / Infection / Non-HLA Antibody Production / Post Transplant Diabetes Mellitus / Quality of Life	1
Not Available	Not Yet Recruiting	Not Available	Nephrotic Syndrome / Pharmacokinetics / Tacrolimus	1
Not Available	Recruiting	Not Available	Biliary Concentration of Tacrolimus	1
Not Available	Recruiting	Not Available	Children / Immunosuppressive Treatment / Nephritis, Lupus / Steroid	1
Not Available	Recruiting	Not Available	Corneal Diseases	1
Not Available	Recruiting	Not Available	Disorder Related to Renal Transplantation	1
Not Available	Recruiting	Not Available	End Stage Liver Diseases / End Stage Renal Disease (ESRD)	1
Not Available	Recruiting	Not Available	End Stage Renal Disease (ESRD)	1
Not Available	Recruiting	Not Available	Kidney; Complications, Allograft / Transplantation Infection	1
Not Available	Recruiting	Not Available	Myasthenia Gravis	1
Not Available	Recruiting	Not Available	Ocular Myasthenia Gravis	1
Not Available	Recruiting	Not Available	Transplantation, Kidney	1
Not Available	Recruiting	Treatment	Acute Lymphoblastic Leukaemias (ALL) / Leukemia Acute Myeloid Leukemia (AML) / Myelodysplastic Syndrome	1
Not Available	Recruiting	Treatment	Adult Acute Lymphoblastic Leukemia in Remission / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / De Novo Myelodysplastic Syndromes / Previously Treated Myelodysplastic Syndromes / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Secondary Myelodysplastic Syndromes / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Adult Acute Myeloid Leukemia	1
Not Available	Recruiting	Treatment	Agnogenic Myeloid Metaplasia / All / Amyloidosis / Bone Marrow Failure Syndromes / Chronic Myeloid Leukemia (CML) / Haemoglobinopathies congenital / HL / Leukemia Acute Myeloid Leukemia (AML) / Multiple Myeloma (MM) / Non-Hodgkin's Lymphoma (NHL) / Smith-Magenis Syndrome	1
Not Available	Recruiting	Treatment	Clinical Trial / Idiopathic Membranous Nephropathy / Tacrolimus	1
Not Available	Recruiting	Treatment	Disorder Related to Renal Transplantation / Effects of Immunosuppressant Therapy	1
Not Available	Recruiting	Treatment	Idiopathic Membranous Nephropathy	1
Not Available	Recruiting	Treatment	Immunosuppression / Liver Transplant Rejection	1
Not Available	Recruiting	Treatment	Corticosteroid / Intralesional Injection / Treatments / Vitiligo	1
Not Available	Recruiting	Treatment	Liver Cirrhosis	1
Not Available	Recruiting	Treatment	Liver Transplantation, Child	1
Not Available	Recruiting	Treatment	Malignancies, Hematologic	1
Not Available	Recruiting	Treatment	Ocular Penetration of Topical Tacrolimus	1
Not Available	Recruiting	Treatment	Renal Transplant Recipient Patients	1
Not Available	Recruiting	Treatment	Transplantation, Kidney	1
Not Available	Recruiting	Treatment	Transplantation, Liver	1
Not Available	Terminated	Not Available	Dried Blood Spot / Transplant Patients / Validation	1
Not Available	Terminated	Not Available	Immunosuppression / Transplant, Kidney	1
Not Available	Terminated	Not Available	Islet Transplantation / Type 1 Diabetes Mellitus	1
Not Available	Terminated	Treatment	Calcineurin Inhibitor Toxicity / Chronic Allograft Injury	1
Not Available	Terminated	Treatment	FSGS	1
Not Available	Terminated	Treatment	Oral Lichen Planus	1
Not Available	Terminated	Treatment	Polycystic Liver Disease (PLD)	1
Not Available	Unknown Status	Not Available	Idiopathic Membranous Nephropathy	1
Not Available	Unknown Status	Not Available	Kidney Transplantation Recipients	1
Not Available	Unknown Status	Treatment	Chronic Myeloproliferative Disorders / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Neoplasms / Renal Cancers	1
Not Available	Unknown Status	Treatment	Glomerulosclerosis, Focal Segmental	1
Not Available	Unknown Status	Treatment	Transplantation, Renal	1
Not Available	Unknown Status	Treatment	MicroRNA Profiles	1
Not Available	Withdrawn	Treatment	Glomerulosclerosis, Focal Segmental	1
Not Available	Withdrawn	Treatment	High Model for End-Stage Liver Disease (MELD) Score	1

Pharmacoeconomics

Manufacturers

Astellas pharma us inc
Dr reddys laboratories ltd
Sandoz inc
Watson laboratories inc
Astellas Pharma US

Packagers

Astellas Pharma Inc.
B&B Pharmaceuticals
Cardinal Health
Caremark LLC
Doctor Reddys Laboratories Ltd.
Kaiser Foundation Hospital
Mckesson Corp.
Murfreesboro Pharmaceutical Nursing Supply
Neuman Distributors Inc.
Physicians Total Care Inc.
Rebel Distributors Corp.
Sandoz
Watson Pharmaceuticals

Dosage forms

Form	Route	Strength
Capsule, extended release	Oral
Capsule, extended release	Oral	0.5 mg
Capsule, extended release	Oral	1 mg
Capsule, extended release	Oral	3 mg
Capsule, extended release	Oral	5 mg
Capsule, coated, extended release	Oral	0.5 mg/1
Capsule, coated, extended release	Oral	1 mg/1
Capsule, coated, extended release	Oral	5 mg/1
Tablet, extended release	Oral	0.75 mg
Tablet, extended release	Oral	1 mg
Tablet, extended release	Oral	4 mg
Tablet, extended release	Oral
Tablet, extended release	Oral	0.75 mg/1
Tablet, extended release	Oral	1 mg/1
Tablet, extended release	Oral	4 mg/1
Cream	Topical
Granule	Oral	0.2 mg
Granule	Oral	1 mg
Ointment	Topical
Capsule	Oral	0.5 mg
Capsule	Oral	1 mg
Capsule	Oral	5 mg
Capsule, gelatin coated	Oral	1 mg/1
Granule, for suspension	Oral	0.2 mg/1
Granule, for suspension	Oral	1 mg/1
Injection, solution	Intravenous	5 mg/1mL
Solution	Intravenous	5 mg
Ointment	Cutaneous	0.03 %
Ointment	Cutaneous	0.1 %
Ointment	Topical	0.03 %
Ointment	Topical	0.1 %
Ointment	Topical	1 mg/1g
Capsule	Oral
Capsule	Oral	0.5 mg/1
Capsule	Oral	1 mg/1
Capsule	Oral	5 mg/1
Capsule, gelatin coated	Oral	0.5 mg/1
Capsule, gelatin coated	Oral	5 mg/1
Ointment	Topical	0.3 mg/1g
Solution	Topical	0.1 g/100g
Cream	Topical	0.1 g/100g
Kit	Topical

Prices

Unit description	Cost	Unit
Tacrolimus micronized powder	2800.0USD	g
Protopic 0.1% Ointment 60 gm Tube	255.34USD	tube
Protopic 0.03% Ointment 60 gm Tube	251.17USD	tube
Prograf 5 mg/ml ampule	163.94USD	ml
Protopic 0.03% Ointment 30 gm Tube	132.99USD	tube
Protopic 0.1% Ointment 30 gm Tube	124.42USD	tube
Prograf 5 mg capsule	24.26USD	capsule
Tacrolimus anhydrous 5 mg cap	22.3USD	each
Prograf 1 mg capsule	4.85USD	capsule
Tacrolimus 1 mg capsule	4.64USD	capsule
Tacrolimus anhydrous 1 mg cap	4.46USD	each
Protopic 0.1% ointment	4.17USD	g
Protopic 0.03% ointment	4.09USD	g
Prograf 0.5 mg capsule	2.43USD	capsule
Tacrolimus anhydrous 0.5 mg cap	2.23USD	each

DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.

Patents

Patent Number	Pediatric Extension	Approved	Expires (estimated)
Unlock Additional Data
US5665727	No	1997-09-09	2014-09-09
US5260301	No	1993-11-09	2011-02-28
CA2037408	No	2002-12-17	2011-03-01
CA1338491	No	1996-07-30	2013-07-30
US6884433	No	2005-04-26	2019-03-25
US6576259	No	2003-06-10	2019-03-25
US8551522	No	2013-10-08	2019-03-25
US6440458	No	2002-08-27	2019-03-25
US9161907	No	2015-10-20	2024-08-30
US8889186	No	2014-11-18	2024-08-30
US8623411	No	2014-01-07	2024-08-30
US8486993	No	2013-07-16	2024-08-30
US8889185	No	2014-11-18	2024-08-30
US8664239	No	2014-03-04	2028-05-30
US8586084	No	2013-11-19	2024-08-30
US8685998	No	2014-04-01	2028-05-30
US8623410	No	2014-01-07	2024-08-30
US8617599	No	2013-12-31	2024-08-30
US7994214	No	2011-08-09	2024-08-30
US8591946	No	2013-11-26	2024-08-30
US9549918	No	2017-01-24	2028-05-30
US9757362	No	2017-09-12	2024-08-30
US9763920	No	2017-09-19	2024-08-30
US10166190	No	2019-01-01	2028-05-30
US8644239	No	2008-08-30	2028-08-30

Additional Data Available

Filed On

The date on which a patent was filed with the relevant government.

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Properties

State

Solid

Experimental Properties

Property	Value	Source
melting point (°C)	126 °C	Not Available
water solubility	Insoluble	FDA label
logP	3.3	Not Available

Predicted Properties

Property	Value	Source
Water Solubility	0.00402 mg/mL	ALOGPS
logP	3.19	ALOGPS
logP	5.59	ChemAxon
logS	-5.3	ALOGPS
pKa (Strongest Acidic)	9.96	ChemAxon
pKa (Strongest Basic)	-2.9	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	11	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	178.36 Å²	ChemAxon
Rotatable Bond Count	7	ChemAxon
Refractivity	215.62 m³·mol^-1	ChemAxon
Polarizability	87.41 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	0	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Predicted ADMET features

Property	Value	Probability
Human Intestinal Absorption	-	0.8264
Blood Brain Barrier	-	0.9659
Caco-2 permeable	-	0.5977
P-glycoprotein substrate	Substrate	0.7862
P-glycoprotein inhibitor I	Inhibitor	0.8687
P-glycoprotein inhibitor II	Inhibitor	0.7974
Renal organic cation transporter	Non-inhibitor	0.8135
CYP450 2C9 substrate	Non-substrate	0.9116
CYP450 2D6 substrate	Non-substrate	0.9116
CYP450 3A4 substrate	Substrate	0.7435
CYP450 1A2 substrate	Non-inhibitor	0.8874
CYP450 2C9 inhibitor	Non-inhibitor	0.9053
CYP450 2D6 inhibitor	Non-inhibitor	0.9402
CYP450 2C19 inhibitor	Non-inhibitor	0.8969
CYP450 3A4 inhibitor	Non-inhibitor	0.869
CYP450 inhibitory promiscuity	Low CYP Inhibitory Promiscuity	0.9807
Ames test	Non AMES toxic	0.6355
Carcinogenicity	Non-carcinogens	0.9422
Biodegradation	Not ready biodegradable	0.9698
Rat acute toxicity	2.7541 LD50, mol/kg	Not applicable
hERG inhibition (predictor I)	Weak inhibitor	0.9817
hERG inhibition (predictor II)	Non-inhibitor	0.8733

ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)

Not Available

Spectra

Spectrum	Spectrum Type	Splash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)	Predicted LC-MS/MS	Not Available

Taxonomy

Description: This compound belongs to the class of organic compounds known as macrolide lactams. These are cyclic polyketides containing both a cyclic amide and a cyclic ester group.
Kingdom: Organic compounds
Super Class: Phenylpropanoids and polyketides
Class: Macrolide lactams
Sub Class: Not Available
Direct Parent: Macrolide lactams
Alternative Parents: Alpha amino acid esters / Macrolides and analogues / Cyclohexanols / Piperidines / Oxanes / Tertiary carboxylic acid amides / Carboxylic acid esters / Cyclic alcohols and derivatives / Cyclic ketones / Hemiacetals
show 10 more
Substituents: Macrolide lactam / Alpha-amino acid ester / Macrolide / Alpha-amino acid or derivatives / Cyclohexanol / Oxane / Piperidine / Cyclic alcohol / Tertiary carboxylic acid amide / Cyclic ketone
show 24 more
Molecular Framework: Aliphatic heteropolycyclic compounds
External Descriptors: macrolide (CHEBI:61049) / Macrolides and lactone polyketides (C01375) / Macrolides and lactone polyketides (LMPK04000003)

Targets

Property	Measurement	pH	Temperature (°C)	References
IC 50 (nM)	1000	N/A	N/A	7241506
IC 50 (nM)	2.3	N/A	N/A	10543889
Ki (nM)	0.4	N/A	N/A	9857082

Details1. Peptidyl-prolyl cis-trans isomerase FKBP1A

Kind: Protein
Organism: Humans
Pharmacological action: Yes
Actions: Inhibitor

General Function: Type i transforming growth factor beta receptor binding
Specific Function: Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevent...
Gene Name: FKBP1A
Uniprot ID: P62942
Uniprot Name: Peptidyl-prolyl cis-trans isomerase FKBP1A
Molecular Weight: 11950.665 Da

References

Labrande C, Velly L, Canolle B, Guillet B, Masmejean F, Nieoullon A, Pisano P: Neuroprotective effects of tacrolimus (FK506) in a model of ischemic cortical cell cultures: role of glutamate uptake and FK506 binding protein 12 kDa. Neuroscience. 2006;137(1):231-9. Epub 2005 Nov 10. [PubMed:16289353]
Masri M, Rizk S, Barbari A, Stephan A, Kamel G, Rost M: An assay for the determination of sirolimus levels in the lymphocyte of transplant patients. Transplant Proc. 2007 May;39(4):1204-6. [PubMed:17524933]

Enzymes

Details1. Cytochrome P450 3A5

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Substrate

General Function: Oxygen binding
Specific Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name: CYP3A5
Uniprot ID: P20815
Uniprot Name: Cytochrome P450 3A5
Molecular Weight: 57108.065 Da

References

Zheng H, Webber S, Zeevi A, Schuetz E, Zhang J, Bowman P, Boyle G, Law Y, Miller S, Lamba J, Burckart GJ: Tacrolimus dosing in pediatric heart transplant patients is related to CYP3A5 and MDR1 gene polymorphisms. Am J Transplant. 2003 Apr;3(4):477-83. [PubMed:12694072]
Kamdem LK, Streit F, Zanger UM, Brockmoller J, Oellerich M, Armstrong VW, Wojnowski L: Contribution of CYP3A5 to the in vitro hepatic clearance of tacrolimus. Clin Chem. 2005 Aug;51(8):1374-81. doi: 10.1373/clinchem.2005.050047. Epub 2005 Jun 10. [PubMed:15951320]
Op den Buijsch RA, Christiaans MH, Stolk LM, de Vries JE, Cheung CY, Undre NA, van Hooff JP, van Dieijen-Visser MP, Bekers O: Tacrolimus pharmacokinetics and pharmacogenetics: influence of adenosine triphosphate-binding cassette B1 (ABCB1) and cytochrome (CYP) 3A polymorphisms. Fundam Clin Pharmacol. 2007 Aug;21(4):427-35. doi: 10.1111/j.1472-8206.2007.00504.x. [PubMed:17635182]
Zheng H, Zeevi A, Schuetz E, Lamba J, McCurry K, Griffith BP, Webber S, Ristich J, Dauber J, Iacono A, Grgurich W, Zaldonis D, McDade K, Zhang J, Burckart GJ: Tacrolimus dosing in adult lung transplant patients is related to cytochrome P4503A5 gene polymorphism. J Clin Pharmacol. 2004 Feb;44(2):135-40. doi: 10.1177/0091270003262108. [PubMed:14747421]

Details2. Cytochrome P450 3A4

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Substrate

General Function: Vitamin d3 25-hydroxylase activity
Specific Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name: CYP3A4
Uniprot ID: P08684
Uniprot Name: Cytochrome P450 3A4
Molecular Weight: 57342.67 Da

References

Ekins S, Bravi G, Wikel JH, Wrighton SA: Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates. J Pharmacol Exp Ther. 1999 Oct;291(1):424-33. [PubMed:10490933]
Rendic S: Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. [PubMed:11996015]
Lampen A, Christians U, Guengerich FP, Watkins PB, Kolars JC, Bader A, Gonschior AK, Dralle H, Hackbarth I, Sewing KF: Metabolism of the immunosuppressant tacrolimus in the small intestine: cytochrome P450, drug interactions, and interindividual variability. Drug Metab Dispos. 1995 Dec;23(12):1315-24. [PubMed:8689938]

Carriers

Details1. Serum albumin

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Substrate

General Function: Toxic substance binding
Specific Function: Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloid...
Gene Name: ALB
Uniprot ID: P02768
Uniprot Name: Serum albumin
Molecular Weight: 69365.94 Da

Details2. Alpha-1-acid glycoprotein 1

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Substrate

General Function: Not Available
Specific Function: Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in...
Gene Name: ORM1
Uniprot ID: P02763
Uniprot Name: Alpha-1-acid glycoprotein 1
Molecular Weight: 23511.38 Da

Transporters

Details1. P-glycoprotein 1

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Substrate
Inhibitor
Inducer

General Function: Xenobiotic-transporting atpase activity
Specific Function: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name: ABCB1
Uniprot ID: P08183
Uniprot Name: Multidrug resistance protein 1
Molecular Weight: 141477.255 Da

References

Schuetz EG, Beck WT, Schuetz JD: Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. Mol Pharmacol. 1996 Feb;49(2):311-8. [PubMed:8632764]
Saeki T, Ueda K, Tanigawara Y, Hori R, Komano T: Human P-glycoprotein transports cyclosporin A and FK506. J Biol Chem. 1993 Mar 25;268(9):6077-80. [PubMed:7681059]
Wandel C, Kim RB, Kajiji S, Guengerich P, Wilkinson GR, Wood AJ: P-glycoprotein and cytochrome P-450 3A inhibition: dissociation of inhibitory potencies. Cancer Res. 1999 Aug 15;59(16):3944-8. [PubMed:10463589]
Hashida T, Masuda S, Uemoto S, Saito H, Tanaka K, Inui K: Pharmacokinetic and prognostic significance of intestinal MDR1 expression in recipients of living-donor liver transplantation. Clin Pharmacol Ther. 2001 May;69(5):308-16. [PubMed:11371998]
Collett A, Tanianis-Hughes J, Hallifax D, Warhurst G: Predicting P-glycoprotein effects on oral absorption: correlation of transport in Caco-2 with drug pharmacokinetics in wild-type and mdr1a(-/-) mice in vivo. Pharm Res. 2004 May;21(5):819-26. [PubMed:15180340]
Quezada CA, Garrido WX, Gonzalez-Oyarzun MA, Rauch MC, Salas MR, San Martin RE, Claude AA, Yanez AJ, Slebe JC, Carcamo JG: Effect of tacrolimus on activity and expression of P-glycoprotein and ATP-binding cassette transporter A5 (ABCA5) proteins in hematoencephalic barrier cells. Biol Pharm Bull. 2008 Oct;31(10):1911-6. [PubMed:18827354]

Details2. ATP-binding cassette sub-family A member 5

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Substrate

General Function: Atpase activity, coupled to transmembrane movement of substances
Specific Function: May play a role in the processing of autolysosomes.
Gene Name: ABCA5
Uniprot ID: Q8WWZ7
Uniprot Name: ATP-binding cassette sub-family A member 5
Molecular Weight: 186505.825 Da

References

Quezada CA, Garrido WX, Gonzalez-Oyarzun MA, Rauch MC, Salas MR, San Martin RE, Claude AA, Yanez AJ, Slebe JC, Carcamo JG: Effect of tacrolimus on activity and expression of P-glycoprotein and ATP-binding cassette transporter A5 (ABCA5) proteins in hematoencephalic barrier cells. Biol Pharm Bull. 2008 Oct;31(10):1911-6. [PubMed:18827354]

Details3. Solute carrier organic anion transporter family member 1B1

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Inhibitor

General Function: Sodium-independent organic anion transmembrane transporter activity
Specific Function: Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostagland...
Gene Name: SLCO1B1
Uniprot ID: Q9Y6L6
Uniprot Name: Solute carrier organic anion transporter family member 1B1
Molecular Weight: 76447.99 Da

References

Kalliokoski A, Niemi M: Impact of OATP transporters on pharmacokinetics. Br J Pharmacol. 2009 Oct;158(3):693-705. doi: 10.1111/j.1476-5381.2009.00430.x. Epub 2009 Sep 25. [PubMed:19785645]

Drug created on June 13, 2005 07:24 / Updated on February 23, 2020 15:42

Tacrolimus

Identification

Structure for Tacrolimus (DB00864)

Pharmacology

Interactions

References

Clinical Trials

Pharmacoeconomics

Properties

Spectra

Taxonomy

Targets

References

Enzymes

References

References

Carriers

Transporters

References

References

References