Abrocitinib

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Abrocitinib
Accession Number
DB14973
Type
Small Molecule
Groups
Investigational
Description

Abrocitinib is under investigation in clinical trial NCT03796676 (JAK1 Inhibitor With Medicated Topical Therapy in Adolescents With Atopic Dermatitis).

Structure
Thumb
Synonyms
  • PF-04965842
Categories
Not Available
UNII
73SM5SF3OR
CAS number
1622902-68-4
Weight
Average: 323.42
Monoisotopic: 323.14159611
Chemical Formula
C14H21N5O2S
InChI Key
IUEWXNHSKRWHDY-PHIMTYICSA-N
InChI
InChI=1S/C14H21N5O2S/c1-3-6-22(20,21)18-10-7-11(8-10)19(2)14-12-4-5-15-13(12)16-9-17-14/h4-5,9-11,18H,3,6-8H2,1-2H3,(H,15,16,17)/t10-,11+
IUPAC Name
SMILES
CCCS(=O)(=O)N[C@H]1C[C@H](C1)N(C)C1=C2C=CNC2=NC=N1

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
58824300
BindingDB
159748
ChEMBL
CHEMBL3655081
HET
D7D
PDB Entries
6bbu / 6bbv

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedBasic ScienceHealthy Volunteers2
1CompletedBasic ScienceHepatic Impairment1
1CompletedOtherHealthy Females1
1CompletedOtherHealthy Volunteers3
1CompletedOtherPhase 11
1CompletedTreatmentHealthy Volunteers3
1RecruitingBasic ScienceHepatic Impairment1
1RecruitingOtherHealthy Volunteers1
2CompletedTreatmentAtopic Dermatitis (AD)1
2Not Yet RecruitingTreatmentAtopic Dermatitis (AD)1
2TerminatedTreatmentPsoriasis Vulgaris (Plaque Psoriasis)1
3CompletedTreatmentAtopic Dermatitis (AD)1
3RecruitingTreatmentAtopic Dermatitis (AD)3
3RecruitingTreatmentAtopic Dermatitis (AD) / Dermatitis, Eczematous / Genetic Diseases, Inborn / Hypersensitivity / Hypersensitivity, Immediate / Immune System Diseases / Skin Diseases / Skin Diseases, Eczematous / Skin Diseases, Genetic / Skin Inflammation2

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on May 20, 2019 08:38 / Updated on May 21, 2019 12:32