Showing BioInteractions for Raltitrexed (DB00293)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
Interacting GroupInteracting Drugs
Raltitrexed is a Thymidylate synthase inhibitor
1Thymidylate synthase inhibitorsCapecitabine, Gemcitabine, Methotrexate, Pemetrexed, Pralatrexate, Tegafur, Trifluridine
2Thymidylate synthase substratesFluorouracil, Methotrexate
3Thymidylate synthase antagonistsTegafur-uracil
Interacting GroupInteracting Drugs
Raltitrexed is a Folylpolyglutamate synthase, mitochondrial antagonist
1Folylpolyglutamate synthase, mitochondrial substratesMethotrexate, Pralatrexate