Identification

Name
Capecitabine
Accession Number
DB01101  (APRD00203)
Type
Small Molecule
Groups
Approved, Investigational
Description

Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue.

Structure
Thumb
Synonyms
  • (1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester
  • Capecitabin
  • Capecitabina
  • Capécitabine
  • Capecitabinum
  • Pentyl [1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate
  • pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate
External IDs
R340 / RO 09-1978/000 / RO-09-1978/000
Active Moieties
NameKindUNIICASInChI Key
FluorouracilprodrugU3P01618RT51-21-8GHASVSINZRGABV-UHFFFAOYSA-N
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Sandoz CapecitabineTablet500 mgOralSandoz Canada Incorporated2014-07-23Not applicableCanada
Sandoz CapecitabineTablet150 mgOralSandoz Canada Incorporated2014-07-23Not applicableCanada
XelodaTablet150 mgOralHoffmann La Roche1998-09-10Not applicableCanada
XelodaTablet, film coated500 mg/1OralGenentech, Inc.1998-04-30Not applicableUs0004 110120180810 16125 cbr16j
XelodaTablet, film coated150 mg/1OralPhysicians Total Care, Inc.2005-02-20Not applicableUs
XelodaTablet, film coated150 mg/1OralGenentech, Inc.1998-04-30Not applicableUs
XelodaTablet, film coated500 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs53808 041120180907 15195 kwmhpm
XelodaTablet500 mgOralHoffmann La Roche1998-09-10Not applicableCanada
XelodaTablet, film coated500 mg/1OralPhysicians Total Care, Inc.2005-06-28Not applicableUs00004 1101 50 nlmimage10 3e3d1f08
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Ach-capecitabineTablet500 mgOralAccord Healthcare Limited2014-09-19Not applicableCanada
Ach-capecitabineTablet150 mgOralAccord Healthcare Limited2014-09-19Not applicableCanada
Apo-capecitabineTablet500 mgOralApotex CorporationNot applicableNot applicableCanada
Apo-capecitabineTablet150 mgOralApotex CorporationNot applicableNot applicableCanada
CapecitabineTablet500 mg/1OralAmneal Pharmaceuticals2017-03-10Not applicableUs
CapecitabineTablet, film coated500 mg/1OralMylan Institutional2014-01-21Not applicableUs
CapecitabineTablet, film coated150 mg/1OralTeva Pharmaceuticals USA, Inc.2014-03-07Not applicableUs0093 747320180907 15195 1qipe8g
CapecitabineTablet, film coated500 mg/1OralNovadoz Pharmaceuticals Llc2018-07-21Not applicableUs
CapecitabineTablet, film coated150 mg/1OralAccord Healthcare Limited2015-06-09Not applicableUs
CapecitabineTablet500 mg/1OralAv Pak2018-03-12Not applicableUs
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Capecitabine SunCapecitabine (150 mg)Tablet, film coatedOralSun Pharmaceutical Industries (Europe) B.V.2013-06-212016-12-22Eu
Capecitabine SunCapecitabine (500 mg)Tablet, film coatedOralSun Pharmaceutical Industries (Europe) B.V.2013-06-212016-12-22Eu
International/Other Brands
Xeloda
Categories
UNII
6804DJ8Z9U
CAS number
154361-50-9
Weight
Average: 359.3501
Monoisotopic: 359.149263656
Chemical Formula
C15H22FN3O6
InChI Key
GAGWJHPBXLXJQN-UORFTKCHSA-N
InChI
InChI=1S/C15H22FN3O6/c1-3-4-5-6-24-15(23)18-12-9(16)7-19(14(22)17-12)13-11(21)10(20)8(2)25-13/h7-8,10-11,13,20-21H,3-6H2,1-2H3,(H,17,18,22,23)/t8-,10-,11-,13-/m1/s1
IUPAC Name
pentyl N-{1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl}carbamate
SMILES
CCCCCOC(=O)NC1=NC(=O)N(C=C1F)[C@@H]1O[C@H](C)[C@@H](O)[C@H]1O

Pharmacology

Indication

For the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen. May also be used in combination with docetaxel for the treatment of metastatic breast cancer in patients who have failed to respond to, or recurred or relasped during or following anthracycline-containing chemotherapy. Capecitabine is used alone as an adjuvant therapy following the complete resection of primary tumor in patients with stage III colon cancer when monotherapy with fluroprymidine is preferred. The use or capecitabine in combination regimens for advanced gastric cancer is currently being investigated.

Associated Conditions
Pharmacodynamics

Capecitabine is a fluoropyrimidine carbamate with antineoplastic activity indicated for the treatment of metastatic breast cancer and colon cancer. It is an orally administered systemic prodrug that has little pharmacologic activity until it is converted to fluorouracil by enzymes that are expressed in higher concentrations in many tumors. Fluorouracil it then metabolized both normal and tumor cells to 5-fluoro-2′-deoxyuridine 5′-monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP).

Mechanism of action

Capecitabine is a prodrug that is selectively tumour-activated to its cytotoxic moiety, fluorouracil, by thymidine phosphorylase, an enzyme found in higher concentrations in many tumors compared to normal tissues or plasma. Fluorouracil is further metabolized to two active metabolites, 5-fluoro-2'-deoxyuridine 5'-monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP), within normal and tumour cells. These metabolites cause cell injury by two different mechanisms. First, FdUMP and the folate cofactor, N5-10-methylenetetrahydrofolate, bind to thymidylate synthase (TS) to form a covalently bound ternary complex. This binding inhibits the formation of thymidylate from 2'-deaxyuridylate. Thymidylate is the necessary precursor of thymidine triphosphate, which is essential for the synthesis of DNA, therefore a deficiency of this compound can inhibit cell division. Secondly, nuclear transcriptional enzymes can mistakenly incorporate FUTP in place of uridine triphosphate (UTP) during the synthesis of RNA. This metabolic error can interfere with RNA processing and protein synthesis through the production of fraudulent RNA.

TargetActionsOrganism
AThymidylate synthase
inhibitor
Human
ADNA
incorporation into and destabilization
Human
ARNA
incorporation into and destabilization
Human
Absorption

Readily absorbed through the GI tract (~70%)

Volume of distribution
Not Available
Protein binding

< 60% (mainly albumin)

Metabolism

Metabolized by thymidine phosphorylase to fluoruracil.

Route of elimination

Capecitabine and its metabolites are predominantly excreted in urine; 95.5% of administered capecitabine dose is recovered in urine. Fecal excretion is minimal (2.6%). The major metabolite excreted in urine is FBAL which represents 57% of the administered dose.About 3% of the administered dose is excreted in urine as unchanged drug.

Half life

45-60 minutes for capecitabine and its metabolites.

Clearance
Not Available
Toxicity
Not Available
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategory
Capecitabine Metabolism PathwayDrug metabolism
Capecitabine Action PathwayDrug action
Pharmacogenomic Effects/ADRs
Interacting Gene/EnzymeAllele nameGenotype(s)Defining Change(s)Type(s)DescriptionDetails
Dihydropyrimidine dehydrogenase [NADP(+)]DPYD*2A(A;A) / (A;G)G > AADR Directly StudiedThe presence of this genotype in DPYD is associated with an increased risk of drug-related toxicity from capecitabine therapy.Details
Dihydropyrimidine dehydrogenase [NADP(+)]DPYD*13(C;C) / (A;C)A > CADR Directly StudiedThe presence of this genotype in DPYD is associated with an increased risk of drug-related toxicity from capecitabine therapy.Details
Dihydropyrimidine dehydrogenase [NADP(+)]---(A;A) / (A;T)T > AADR Directly StudiedThe presence of this genotype in DPYD may be associated with an increased risk of drug-related toxicity from capecitabine therapy.Details
Dihydropyrimidine dehydrogenase [NADP(+)]DPYD*4(G;G) / (A:G)G > AADR Directly StudiedThe presence of this genotype in DPYD may be associated with an increased risk of drug-related toxicity from capecitabine therapy.Details
Dihydropyrimidine dehydrogenase [NADP(+)]DPYD*5(G;G) / (A;G)A > GADR Directly StudiedThe presence of this genotype in DPYD may be associated with an increased risk of drug-related toxicity from capecitabine therapy.Details
Dihydropyrimidine dehydrogenase [NADP(+)]DPYD*6(A;A) / (A;G)G > AADR Directly StudiedThe presence of this genotype in DPYD may be associated with an increased risk of drug-related toxicity from capecitabine therapy.Details
Dihydropyrimidine dehydrogenase [NADP(+)]DPYD*9A(C;C) / (C;T)T > CADR Directly StudiedThe presence of this genotype in DPYD may be associated with an increased risk of drug-related toxicity from capecitabine therapy.Details

Interactions

Drug Interactions
DrugInteraction
AceclofenacThe metabolism of Aceclofenac can be decreased when combined with Capecitabine.
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Capecitabine.
AcetaminophenAcetaminophen may decrease the excretion rate of Capecitabine which could result in a higher serum level.
Acetyl sulfisoxazoleThe metabolism of Acetyl sulfisoxazole can be decreased when combined with Capecitabine.
AcetyldigitoxinAcetyldigitoxin may decrease the cardiotoxic activities of Capecitabine.
AcetyldigoxinAcetyldigoxin may decrease the cardiotoxic activities of Capecitabine.
Acetylsalicylic acidAcetylsalicylic acid may decrease the excretion rate of Capecitabine which could result in a higher serum level.
AdalimumabThe risk or severity of adverse effects can be increased when Adalimumab is combined with Capecitabine.
AlclometasoneThe risk or severity of adverse effects can be increased when Capecitabine is combined with Alclometasone.
AldesleukinThe risk or severity of adverse effects can be increased when Capecitabine is combined with Aldesleukin.
Food Interactions
  • Take 12 hours apart, within 30 minutes of the end of breakfast and dinner to reduce nausea.

References

Synthesis Reference
US5472949
General References
  1. Walko CM, Lindley C: Capecitabine: a review. Clin Ther. 2005 Jan;27(1):23-44. [PubMed:15763604]
  2. Wagstaff AJ, Ibbotson T, Goa KL: Capecitabine: a review of its pharmacology and therapeutic efficacy in the management of advanced breast cancer. Drugs. 2003;63(2):217-36. [PubMed:12515569]
  3. Koukourakis GV, Kouloulias V, Koukourakis MJ, Zacharias GA, Zabatis H, Kouvaris J: Efficacy of the oral fluorouracil pro-drug capecitabine in cancer treatment: a review. Molecules. 2008 Aug 27;13(8):1897-922. [PubMed:18794792]
  4. Twelves C: Vision of the future: capecitabine. Oncologist. 2001;6 Suppl 4:35-9. [PubMed:11585973]
  5. Milano G, Ferrero JM, Francois E: Comparative pharmacology of oral fluoropyrimidines: a focus on pharmacokinetics, pharmacodynamics and pharmacomodulation. Br J Cancer. 2004 Aug 16;91(4):613-7. [PubMed:15280932]
  6. de Bono JS, Twelves CJ: The oral fluorinated pyrimidines. Invest New Drugs. 2001;19(1):41-59. [PubMed:11291832]
External Links
Human Metabolome Database
HMDB0015233
KEGG Drug
D01223
KEGG Compound
C12650
PubChem Compound
60953
PubChem Substance
46508686
ChemSpider
54916
ChEBI
31348
ChEMBL
CHEMBL1773
Therapeutic Targets Database
DAP000761
PharmGKB
PA448771
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Capecitabine
ATC Codes
L01BC06 — Capecitabine
AHFS Codes
  • 10:00.00 — Antineoplastic Agents
FDA label
Download (133 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedTreatmentAcinar Cell Adenocarcinoma of the Pancreas / Duct Cell Adenocarcinoma of the Pancreas / Recurrent Pancreatic Cancer / Stage II Pancreatic Cancer / Stage III Pancreatic Cancer1
0RecruitingTreatmentGastrointestinal Cancers1
1Active Not RecruitingTreatmentAdvanced Cancers1
1Active Not RecruitingTreatmentCancer of the Ovary / Cancer, Breast / Carcinoma, Colorectal / Carcinoma, Pancreatic / Melanoma / Non-Small Cell Lung Carcinoma (NSCLC) / Prostate Cancer / Renal Cell Adenocarcinoma / Tumors, Solid1
1Active Not RecruitingTreatmentCancer, Breast1
1Active Not RecruitingTreatmentCancers / Metastatic Colorectal Cancer (MCRC) / Tumors, Solid1
1Active Not RecruitingTreatmentEsophageal Cancers / Malignant Neoplasm of Cardio-esophageal Junction of Stomach1
1Active Not RecruitingTreatmentEsophageal Cancers / Neoplasms, Esophageal1
1Active Not RecruitingTreatmentHER2 Positive Metastatic Breast Cancers1
1Active Not RecruitingTreatmentLiver Cancer / Metastatic Cancers1
1Active Not RecruitingTreatmentMetastatic Breast Cancer (MBC)1
1Active Not RecruitingTreatmentNeoplasms1
1Active Not RecruitingTreatmentTumors, Solid1
1CompletedPreventionNeoplasms1
1CompletedTreatmentAdult Grade III Lymphomatoid Granulomatosis / Adult Nasal Type Extranodal NK/T-Cell Lymphoma / AIDS-Related Diffuse Large Cell Lymphoma / AIDS-Related Diffuse Mixed Cell Lymphoma / AIDS-Related Diffuse Small Cleaved Cell Lymphoma / AIDS-related Immunoblastic Large Cell Lymphoma / AIDS-Related Lymphoblastic Lymphoma / AIDS-related Peripheral/Systemic Lymphoma / AIDS-related Primary CNS Lymphoma / AIDS-related Small Noncleaved Cell Lymphoma / Anaplastic Large Cell Lymphoma / Angioimmunoblastic T-Cell Lymphoma / Cutaneous B-Cell Non-Hodgkin Lymphoma / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / HER2-Negative Breast Cancer / HIV-associated Hodgkin Lymphoma / Intraocular Lymphoma / Male Breast Cancer / Metastatic Colon Cancer / Nodal marginal zone B-cell lymphomas / Post-Transplant Lymphoproliferative Disorder / Primary Central Nervous System Hodgkin Lymphoma / Primary Central Nervous System Non-Hodgkin Lymphoma / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Grade III Lymphomatoid Granulomatosis / Recurrent Adult Hodgkin's Lymphoma / Recurrent Adult Immunoblastic Large Cell Lymphoma / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Adult T-Cell Leukemia/Lymphoma / Recurrent Breast Cancer / Recurrent Colon Cancer / Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Mycosis Fungoides/Sezary Syndrome / Recurrent Rectal Cancer / Recurrent Small Lymphocytic Lymphoma / Small Intestine Lymphoma / Splenic Marginal Zone Lymphoma / Stage III Adult Burkitt Lymphoma / Stage III Adult Diffuse Large Cell Lymphoma / Stage III Adult Diffuse Mixed Cell Lymphoma / Stage III Adult Diffuse Small Cleaved Cell Lymphoma / Stage III Adult Hodgkin Lymphoma / Stage III Adult Immunoblastic Large Cell Lymphoma / Stage III Adult Lymphoblastic Lymphoma / Stage III Adult T-Cell Leukemia/Lymphoma / Stage III Colon Cancer / Stage III Cutaneous T-Cell Non-Hodgkin Lymphoma / Stage III Grade 1 Follicular Lymphoma / Stage III Grade 2 Follicular Lymphoma / Stage III Grade 3 Follicular Lymphoma / Stage III Mantle Cell Lymphoma / Stage III Marginal Zone Lymphoma / Stage III Mycosis Fungoides/Sezary Syndrome / Stage III Rectal Cancer / Stage III Small Lymphocytic Lymphoma / Stage IIIA Breast Cancer / Stage IIIB Breast Cancer / Stage IIIC Breast Cancer / Stage IV Adult Burkitt Lymphoma / Stage IV Adult Diffuse Large Cell Lymphoma / Stage IV Adult Diffuse Mixed Cell Lymphoma / Stage IV Adult Diffuse Small Cleaved Cell Lymphoma / Stage IV Adult Hodgkin Lymphoma / Stage IV Adult Immunoblastic Large Cell Lymphoma / Stage IV Adult Lymphoblastic Lymphoma / Stage IV Adult T-Cell Leukemia/Lymphoma / Stage IV Breast Cancer / Stage IV Cutaneous T-Cell Non-Hodgkin Lymphoma / Stage IV Grade 1 Follicular Lymphoma / Stage IV Grade 2 Follicular Lymphoma / Stage IV Grade 3 Follicular Lymphoma / Stage IV Mantle Cell Lymphoma / Stage IV Marginal Zone Lymphoma / Stage IV Mycosis Fungoides/Sezary Syndrome / Stage IV Rectal Cancer / Stage IV Small Lymphocytic Lymphoma / Unspecified Adult Solid Tumor, Protocol Specific / Waldenström's Macroglobulinemia (WM)1
1CompletedTreatmentAdenocarcinoma of the Pancreas / Stage III Pancreatic Cancer / Stage IV Pancreatic Cancer / Unspecified Adult Solid Tumor, Protocol Specific1
1CompletedTreatmentAdenocarcinomas / Malignant Neoplasm of Pancreas / Neoplasms, Pancreatic1
1CompletedTreatmentAdults / Tumors, Solid1
1CompletedTreatmentAdvanced Breast Cancer1
1CompletedTreatmentAdvanced Colorectal Cancer / Metastatic Colorectal Cancers / Neoplasms, Colorectal / Responsive to Fluoropyrimidines1
1CompletedTreatmentAdvanced Gastric Cancer1
1CompletedTreatmentAdvanced Gastric Cancer / Stomach Neoplasms1
1CompletedTreatmentAdvanced Gastrointestinal Malignancies / Tumors, Solid1
1CompletedTreatmentAdvanced Malignant Solid Tumors1
1CompletedTreatmentAdvanced Solid Tumors1
1CompletedTreatmentAdvanced Solid Tumors / Locally Advanced or Metastatic Breast or Colorectal Cancer1
1CompletedTreatmentAdvanced Solid Tumors / Neoplasms1
1CompletedTreatmentAdvanced or Metastatic Biliary Tract Cancer / Advanced or Metastatic Solid Tumors1
1CompletedTreatmentAnal, Colon, and Rectal Cancers / Colon/Rectal Cancer / Neoplasms, Colorectal1
1CompletedTreatmentBiliary Cancer / Malignant Neoplasm of Pancreas1
1CompletedTreatmentBiliary Cancer / Malignant Neoplasm of Pancreas / Malignant Solid Tumours1
1CompletedTreatmentBrain and Central Nervous System Tumors1
1CompletedTreatmentBreast Cancer, Colorectal Cancer1
1CompletedTreatmentCancer, Advanced1
1CompletedTreatmentCancer, Advanced / Tumors, Solid1
1CompletedTreatmentCancer, Breast6
1CompletedTreatmentCancer, Breast / Malignant Neoplasm of Colon1
1CompletedTreatmentCancer, Breast / Neoplasms / Tumors, Solid1
1CompletedTreatmentCancers3
1CompletedTreatmentCancers / Pancreas1
1CompletedTreatmentCancers / Unspecified Adult Solid Tumor, Protocol Specific1
1CompletedTreatmentCarcinoma of the Appendix / Colorectal Cancers / Small Intestine Cancer1
1CompletedTreatmentColorectal Cancers2
1CompletedTreatmentColorectal Cancers / Lung Cancers / Unspecified Adult Solid Tumor, Protocol Specific1
1CompletedTreatmentEsophageal Cancers2
1CompletedTreatmentEsophagus Disorders / Squamous Carcinoma of Esophagus1
1CompletedTreatmentExtrahepatic Bile Duct Cancer / Gallbladder Cancer / Liver Cancer / Malignant Neoplasm of Stomach / Unspecified Adult Solid Tumor, Protocol Specific1
1CompletedTreatmentGastrointestinal Tumors / Metastatic Breast Cancer (MBC)1
1CompletedTreatmentGliomas1
1CompletedTreatmentHER-2 Gene Amplification1
1CompletedTreatmentHead and Neck Carcinoma1
1CompletedTreatmentLocally Advanced Breast Cancer (LABC) / Metastatic Breast Cancer (MBC)1
1CompletedTreatmentLocally Advanced Rectal Cancer1
1CompletedTreatmentMalignant Neoplasm of Colon1
1CompletedTreatmentMalignant Neoplasm of Pancreas8
1CompletedTreatmentMalignant Neoplasm of Pancreas / Metastatic Breast Cancer (MBC) / Metastatic Colorectal Cancers / Unresectable Metastatic Breast Cancer (MBC), Pancreatic Cancer (PC) or Metastatic Colorectal Cancer (CRC)1
1CompletedTreatmentMalignant Neoplasm of Pancreas / Periampullary Adenocarcinoma1
1CompletedTreatmentMalignant Neoplasm of Stomach3
1CompletedTreatmentMetastatic Biliary Tract Cancer / Metastatic Breast Cancer (MBC) / Metastatic Colorectal Cancers / Metastatic Gastric Cancers / Metastatic Oesophageal Cancers / Pancreatic Cancer Metastatic1
1CompletedTreatmentMetastatic Breast Cancer (MBC)2
1CompletedTreatmentMetastatic Breast Cancer or Metastatic Colorectal Cancer1
1CompletedTreatmentMetastatic Colorectal Cancers / Tumors, Solid1
1CompletedTreatmentMetastatic Pancreatic Carcinoma1
1CompletedTreatmentMetastatic or Unresectable Solid Tumor Malignancy1
1CompletedTreatmentNeoplasms2
1CompletedTreatmentNeoplasms, Colorectal1
1CompletedTreatmentNeoplasms, Esophageal1
1CompletedTreatmentNeoplasms, Esophageal / Stomach Neoplasms1
1CompletedTreatmentRectal Adenocarcinoma1
1CompletedTreatmentRectal Carcinoma2
1CompletedTreatmentRectal Neoplasms2
1CompletedTreatmentRecurrent Colon Cancer / Recurrent Rectal Cancer / Stage IIIC Colon Cancer / Stage IIIC Rectal Cancer / Stage IVA Colon Cancer / Stage IVA Rectal Cancer / Stage IVB Colon Cancer / Stage IVB Rectal Cancer / Unspecified Adult Solid Tumor, Protocol Specific1
1CompletedTreatmentRefractory Malignancy1
1CompletedTreatmentSolid Cancers1
1CompletedTreatmentSolid Tumor Cancers1
1CompletedTreatmentStomach Neoplasms2
1CompletedTreatmentTumors, Solid3
1CompletedTreatmentUnspecified Adult Solid Tumor, Protocol Specific11
1CompletedTreatmentMetastatic Hepatic Cancer1
1Enrolling by InvitationOtherMetastatic Colorectal Cancers1
1Not Yet RecruitingTreatmentAdenocarcinoma Of Esophagus / Squamous Cell Carcinoma (SCC) / Tumors, Solid1
1Not Yet RecruitingTreatmentCancer, Advanced / Malignant Neoplasm of Breast / Malignant Neoplasms of Bone and Articular Cartilage / Malignant Neoplasms of Digestive Organs / Malignant Neoplasms of Eye Brain and Other Parts of Central Nervous System / Malignant Neoplasms of Female Genital Organs / Malignant Neoplasms of Ill-defined Secondary and Unspecified Sites / Malignant Neoplasms of Independent (Primary) Multiple Sites / Malignant Neoplasms of Lip Oral Cavity and Pharynx / Malignant Neoplasms of Male Genital Organs / Malignant Neoplasms of Mesothelial and Soft Tissue / Malignant Neoplasms of Respiratory and Intrathoracic Organs / Malignant Neoplasms of Thyroid and Other Endocrine Glands / Malignant Neoplasms of Urinary Tract1
1Not Yet RecruitingTreatmentCancer, Breast / Malignant Neoplasm of Colon1
1Not Yet RecruitingTreatmentNeoplasms, Colorectal / Neoplasms, Esophageal / Stomach Neoplasms1
1RecruitingTreatmentAdvanced Cancers1
1RecruitingTreatmentAdvanced Malignant Solid Neoplasm / Bile Duct Carcinoma / Recurrent Malignant Solid Neoplasm / Recurrent Pancreatic Carcinoma / Solid Neoplasms / Stage III Pancreatic Cancer / Stage III Pancreatic Cancer AJCC v6 and v7 / Stage IVA Pancreatic Cancer / Stage IVB Pancreatic Cancer1
1RecruitingTreatmentCancer, Breast1
1RecruitingTreatmentCancer, Breast / Metastatic Breast Cancer (MBC)1
1RecruitingTreatmentCancers / Malignant Neoplasm of Pancreas1
1RecruitingTreatmentCarcinoma NOS1
1RecruitingTreatmentGlioblastomas1
1RecruitingTreatmentHER2-expressing Cancers1
1RecruitingTreatmentHepatocellular,Carcinoma1
1RecruitingTreatmentMalignant Neoplasm of Pancreas2
1RecruitingTreatmentNeoadjuvant Therapy in Rectal Cancer1
1RecruitingTreatmentRectal Adenocarcinoma / Rectal Carcinoma1
1RecruitingTreatmentRectal Adenocarcinoma / Stage III Rectal Cancer AJCC v7 / Stage IIIA Rectal Cancer AJCC v7 / Stage IIIB Rectal Cancer AJCC v7 / Stage IIIC Rectal Cancer AJCC v7 / Stage IV Rectal Cancer AJCC v7 / Stage IVA Rectal Cancer AJCC v7 / Stage IVB Rectal Cancer AJCC v71
1RecruitingTreatmentRectal Carcinoma2
1RecruitingTreatmentRectal Neoplasms1
1RecruitingTreatmentStage IA Pancreatic Cancer / Stage IB Pancreatic Cancer / Stage IIA Pancreatic Cancer / Stage IIB Pancreatic Cancer1
1RecruitingTreatmentTumors, Solid2
1TerminatedTreatmentAdenocarcinoma of the Pancreas / Adenocarcinoma of the Stomach / Advanced Gastric Cancer / Brca1 Mutation Carrier / Brca2 Mutation Carrier / Metastatic Colon Cancer / Ovarian Mucinous Cystadenocarcinoma / Recurrent Breast Cancer / Recurrent Colon Cancer / Recurrent Gastric Cancer / Recurrent Ovarian Epithelial Cancer / Recurrent Ovarian Germ Cell Tumor / Recurrent Pancreatic Cancer / Recurrent Rectal Cancer / Stage IA Breast Cancer / Stage IB Breast Cancer / Stage II Breast Cancer / Stage IIIA Breast Cancer / Stage IIIB Breast Cancer / Stage IIIC Breast Cancer / Stage IV Breast Cancer / Stage IV Ovarian Epithelial Cancer / Stage IV Ovarian Germ Cell Tumor / Stage IV Pancreatic Cancer / Stage IV Rectal Cancer / Unspecified Adult Solid Tumor, Protocol Specific1
1TerminatedTreatmentAdenocarcinomas / Esophageal Cancers / Neoplasms, Esophageal / Squamous Cell Carcinoma (SCC)1
1TerminatedTreatmentCancer of Liver1
1TerminatedTreatmentCancer, Breast1
1TerminatedTreatmentColorectal Cancers / Malignant Neoplasm of Stomach1
1TerminatedTreatmentColorectal Cancers / Unspecified Adult Solid Tumor, Protocol Specific1
1TerminatedTreatmentFailure or Contraindication of Trastuzumab Therapy / First or Second Line Therapy / HER2 Positive / Metastatic Breast Cancer (MBC)1
1TerminatedTreatmentLocally Advanced or Metastatic Breast Cancer1
1TerminatedTreatmentMalignancies1
1TerminatedTreatmentNeoplasms1
1TerminatedTreatmentNon-Metastatic Adenocarcinoma of the Rectum1
1TerminatedTreatmentNon-Small Cell Lung Carcinoma (NSCLC)1
1TerminatedTreatmentRelapsed/Refractory Metastatic Pancreatic Ductal Adenocarcinoma1
1Unknown StatusTreatmentGastric Carcinoma1
1Unknown StatusTreatmentRectal Carcinoma1
1Unknown StatusTreatmentTumors, Solid1
1WithdrawnTreatmentCancer of the Ovary / Cervical Cancers / Endometrial Cancers / Vaginal Cancers1
1WithdrawnTreatmentFunctional Pancreatic Neuroendocrine Tumor / Malignant Somatostatinoma / Metastatic Adrenal Gland Pheochromocytoma / Metastatic Carcinoid Tumors / Multiple Endocrine Neoplasia Type 1 / Multiple Endocrine Neoplasia Type 2a / Multiple Endocrine Neoplasia Type 2B / Neuroendocrine Carcinoma of the Skin / Neuroendocrine Neoplasms / Non-Functional Pancreatic Neuroendocrine Tumor / Pancreatic Glucagonoma / Pancreatic Insulinoma / Recurrent Adrenal Cortex Carcinoma / Recurrent Adrenal Gland Pheochromocytoma / Recurrent Merkel Cell Carcinoma / Somatostatin-Producing Neuroendocrine Tumor / Stage III Adrenal Cortex Carcinoma / Stage III Thyroid Gland Medullary Carcinoma / Stage IIIA Merkel Cell Carcinoma / Stage IIIB Merkel Cell Carcinoma / Stage IV Adrenal Cortex Carcinoma / Stage IV Merkel Cell Carcinoma / Stage IVA Thyroid Gland Medullary Carcinoma / Stage IVB Thyroid Gland Medullary Carcinoma / Stage IVC Thyroid Gland Medullary Carcinoma / Thymic Carcinoid Tumor / VIP-Producing Neuroendocrine Tumor / Well Differentiated Adrenal Cortex Carcinoma / Zollinger-Ellison Syndrome1
1WithdrawnTreatmentMalignant Neoplasm of Pancreas1
1, 2Active Not RecruitingTreatmentAdvanced Gastrointestinal Cancers1
1, 2Active Not RecruitingTreatmentBiliary Tract Cancer1
1, 2Active Not RecruitingTreatmentCancer of Pancreas / Cancer of the Pancreas / Malignant Neoplasm of Pancreas1
1, 2Active Not RecruitingTreatmentCentral Nervous System Metastases / Her2-Positive Breast Cancer / Male Breast Cancer / Recurrent Breast Cancer / Stage IV Breast Cancer1
1, 2Active Not RecruitingTreatmentColon Adenocarcinoma / Rectal Adenocarcinoma / Recurrent Colon Carcinoma / Recurrent Rectal Carcinoma / Stage IVA Colon Cancer / Stage IVA Rectal Cancer / Stage IVB Colon Cancer / Stage IVB Rectal Cancer1
1, 2Active Not RecruitingTreatmentColorectal Adenocarcinoma1
1, 2Active Not RecruitingTreatmentHER2 Positive Metastatic Breast Cancers1
1, 2Active Not RecruitingTreatmentMalignant Neoplasm of Pancreas2
1, 2Active Not RecruitingTreatmentPancreatic Adenocarcinoma Metastatic1
1, 2Active Not RecruitingTreatmentRectal Carcinoma1
1, 2CompletedTreatmentAdult Solid Neoplasm / Inflammatory Breast Carcinoma / Male Breast Carcinoma / Stage IIIA Breast Cancer / Stage IIIB Breast Cancer1
1, 2CompletedTreatmentAdvanced Gastric Cancer1
1, 2CompletedTreatmentBile Duct Neoplasms / Neoplasms, Pancreatic1
1, 2CompletedTreatmentCancer of the Esophagus1
1, 2CompletedTreatmentCancer, Breast5
1, 2CompletedTreatmentCancer, Breast / Cancers1
1, 2CompletedTreatmentCholangiocarcinomas1
1, 2CompletedTreatmentColorectal Cancers7
1, 2CompletedTreatmentEsophageal Cancers / Esophagogastric Junction Adenocarcinoma / Malignant Neoplasm of Stomach1
1, 2CompletedTreatmentEsophageal Cancers / Extrahepatic Bile Duct Cancer / Head and Neck Carcinoma / Liver Cancer / Malignant Neoplasm of Stomach / Unspecified Adult Solid Tumor, Protocol Specific1
1, 2CompletedTreatmentEsophagus Cancer1
1, 2CompletedTreatmentHepatocellular,Carcinoma / Liver Cancer1
1, 2CompletedTreatmentHistone Deacetylase Inhibitor / Malignant Neoplasm of Stomach1
1, 2CompletedTreatmentLocally Advanced Pancreatic Cancer / Pancreatic Cancer Metastatic1
1, 2CompletedTreatmentMalignant Neoplasm of Pancreas3
1, 2CompletedTreatmentMetastatic Breast Cancer (MBC)1
1, 2CompletedTreatmentMetastatic Colorectal Cancers2
1, 2CompletedTreatmentMetastatic Gastric Cancers1
1, 2CompletedTreatmentNeoplasm Metastases / Neoplasms, Breast1
1, 2CompletedTreatmentPancreatic Cancer Metastatic1
1, 2CompletedTreatmentRectal Carcinoma1
1, 2CompletedTreatmentRenal Cell Carcinoma Recurrent / Stage III Renal Cell Cancer / Stage III Renal Cell Cancer AJCC v7 / Stage IV Renal Cell Cancer / Stage IV Renal Cell Cancer AJCC V71
1, 2CompletedTreatmentStage IV Colorectal Cancer1
1, 2Enrolling by InvitationTreatmentTumors, Solid1
1, 2Not Yet RecruitingTreatmentAdenocarcinoma of the Pancreas / Colorectal Adenocarcinoma / Metastatic Colorectal Cancers / Pancreatic Cancer Metastatic1
1, 2Not Yet RecruitingTreatmentCancer of the Ovary1
1, 2Not Yet RecruitingTreatmentChildhood Lymphoma / Childhood Solid Tumors1
1, 2Not Yet RecruitingTreatmentColorectal Cancers1
1, 2Not Yet RecruitingTreatmentHead and Neck Squamous Cell Carcinoma (HNSCC)1
1, 2Not Yet RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
1, 2Not Yet RecruitingTreatmentMelanoma1
1, 2Not Yet RecruitingTreatmentMetastatic Colorectal Cancers / Metastatic Solid Tumor Cancer / Recurrent Head and Neck Cancer1
1, 2Not Yet RecruitingTreatmentNeuroendocrine Carcinoma of the Skin1
1, 2Not Yet RecruitingTreatmentNon Hodgkin Lymphoma (NHL)1
1, 2Not Yet RecruitingTreatmentRectal Carcinoma1
1, 2Not Yet RecruitingTreatmentTransitional Cell Carcinoma1
1, 2Not Yet RecruitingTreatmentTriple Negative Breast Cancer (TNBC)1
1, 2RecruitingTreatmentAdenocarcinomas / Digestive System Diseases / Digestive System Neoplasms / Endocrine Gland Neoplasms / Endocrine System Diseases / Neoplasm, Glandular / Neoplasms / Neoplasms Pancreatic / Neoplasms, Pancreatic / Pancreatic Diseases1
1, 2RecruitingTreatmentBrain Cancer / Brain Tumor Adult / Cancers / Glioblastoma Multiforme (GBM) / Glioblastoma, Adult / Glioblastomas / Glioma of Brain / Neoplasms, Brain / Primary Brain Tumors1
1, 2RecruitingTreatmentCancer, Breast1
1, 2RecruitingTreatmentCancers1
1, 2RecruitingTreatmentColorectal Cancers2
1, 2RecruitingTreatmentColorectal Cancers / Malignant Neoplasm of Colon / Rectal Carcinoma / Tumors, Solid1
1, 2RecruitingTreatmentEsophageal Cancers1
1, 2RecruitingTreatmentHepatocellular Carcinoma Non-resectable / Recurrent Hepatocellular Carcinoma1
1, 2RecruitingTreatmentMalignant Neoplasm of Pancreas2
1, 2RecruitingTreatmentMalignant Neoplasm of Stomach1
1, 2RecruitingTreatmentMetastatic Colorectal Cancers1
1, 2RecruitingTreatmentMCRC / Metastatic Colorectal Cancers1
1, 2RecruitingTreatmentPancreatic Neoplasms (Locally Advanced Non-metastatic)1
1, 2RecruitingTreatmentRectal Carcinoma2
1, 2RecruitingTreatmentSquamous Cell Carcinoma (SCC)1
1, 2RecruitingTreatmentTriple Negative Breast Cancer (TNBC)3
1, 2TerminatedTreatmentAdenocarcinoma Of Esophagus / Gastric Adenocarcinoma1
1, 2TerminatedTreatmentAdenocarcinomas / Tumors / Unknown Primary Tumors1
1, 2TerminatedTreatmentAdvanced Breast Cancer (Parts 1 and 2) / Advanced Cholangiocarcinoma (Part 1) / Advanced Colorectal Cancer (Part 1) / Advanced Glioblastoma Multiforme (Part 1) / Advanced Pancreatic Cancer (Part 1)1
1, 2TerminatedTreatmentAdvanced or Metastatic Solid Tumors / Previously Untreated Gastric Cancer1
1, 2TerminatedTreatmentCancer, Advanced / Carcinoma, Colorectal / Endometrial / Lung Cancer Non-Small Cell Cancer (NSCLC) / Malignant Neoplasm of Pancreas / Renal Cell Adenocarcinoma / Uterine1
1, 2TerminatedTreatmentCancer, Breast1
1, 2TerminatedTreatmentColo-rectal Cancer / Colon/Rectal Cancer / Colon/Rectal Cancer Rectal Cancer / Rectal Carcinoma1
1, 2TerminatedTreatmentColorectal Cancers1
1, 2TerminatedTreatmentEsophageal Cancers / Malignant Neoplasm of Stomach / Tumors1
1, 2TerminatedTreatmentHER2 + Breast Cancer / Metastatic Breast Cancer (MBC)1
1, 2TerminatedTreatmentMalignant Neoplasm of Pancreas2
1, 2TerminatedTreatmentMalignant Neoplasm of Stomach1
1, 2TerminatedTreatmentMetastatic Cancers1
1, 2TerminatedTreatmentMetastatic Colorectal Cancers1
1, 2TerminatedTreatmentStage II Rectal Cancer / Stage III Rectal Cancer1
1, 2TerminatedTreatmentThyroid Cancers / Tumors, Solid1
1, 2Unknown StatusNot AvailableCancer treatment / Neoplasms, Breast1
1, 2Unknown StatusTreatmentAdvanced Gastric Cancer1
1, 2Unknown StatusTreatmentAdvanced Malignancies1
1, 2Unknown StatusTreatmentAdvanced Solid Tumors1
1, 2Unknown StatusTreatmentCancer of the Esophagus / Gastric Cardia Carcinoma1
1, 2Unknown StatusTreatmentColorectal Cancers1
1, 2Unknown StatusTreatmentGastric Carcinoma1
1, 2WithdrawnTreatmentCancer, Breast / Metastatic Breast Cancer (MBC) / Stage IV Breast Cancer1
1, 2WithdrawnTreatmentMalignant Neoplasm of Pancreas1
1, 2WithdrawnTreatmentRectal Carcinoma1
2Active Not RecruitingNot AvailableAdenocarcinoma of the Gastro-oesophageal Junction / Metastatic Gastric Cancers1
2Active Not RecruitingOtherPancreatic Adenocarcinoma Metastatic1
2Active Not RecruitingTreatmentAdenocarcinoma of the Pancreas1
2Active Not RecruitingTreatmentAdenocarcinomas of the Gastroesophageal Junction1
2Active Not RecruitingTreatmentAdenocarcinomas of the Gastroesophageal Junction / Esophageal Cancers / Malignant Neoplasm of Stomach1
2Active Not RecruitingTreatmentAdenocarcinomas of the Gastroesophageal Junction / Gastric Adenocarcinoma1
2Active Not RecruitingTreatmentAdenocarcinomas of the Gastroesophageal Junction / Gastric Adenocarcinoma / Malignant Neoplasm of Stomach1
2Active Not RecruitingTreatmentAdenocarcinomas / Rectal Neoplasms1
2Active Not RecruitingTreatmentAdult Cholangiocarcinoma / Advanced Adult Hepatocellular Carcinoma / BCLC Stage C Adult Hepatocellular Carcinoma / BCLC Stage D Adult Hepatocellular Carcinoma / Hilar Cholangiocarcinoma / Localized Non-Resectable Adult Liver Carcinoma / Recurrent Adult Liver Carcinoma / Recurrent Childhood Liver Cancer / Recurrent Extrahepatic Bile Duct Carcinoma / Recurrent Gallbladder Carcinoma / Stage II Gallbladder Cancer / Stage III Childhood Hepatocellular Carcinoma / Stage IIIA Gallbladder Cancer / Stage IIIB Gallbladder Cancer / Stage IV Childhood Hepatocellular Carcinoma / Stage IV Distal Bile Duct Cancer / Stage IVA Gallbladder Cancer / Stage IVB Gallbladder Cancer / Unresectable Extrahepatic Bile Duct Carcinoma1
2Active Not RecruitingTreatmentAdvanced Colorectal Cancer1
2Active Not RecruitingTreatmentAdvanced Gastric Cancer1
2Active Not RecruitingTreatmentAnal Basaloid Carcinoma / Anal Canal Cloacogenic Carcinoma / Anal Squamous Cell Carcinoma / Metastatic Anal Canal Carcinoma / Recurrent Anal Canal Carcinoma / Stage IIIB Anal Canal Cancer / Stage IV Anal Canal Cancer1
2Active Not RecruitingTreatmentCLDN18.2-positive Adenocarcinoma of Esophagus / CLDN18.2-positive Adenocarcinoma of the Gastroesophageal Junction / CLDN18.2-positive Gastric Adenocarcinoma1
2Active Not RecruitingTreatmentCancer, Breast3
2Active Not RecruitingTreatmentCancer, Breast / Metastatic Brain Tumors / Metastatic Breast Cancer (MBC) / Triple Negative Breast Cancer (TNBC)1
2Active Not RecruitingTreatmentCarcinoma, Islet Cell / Gastrinoma / Glucagonoma / Insulinoma / Pancreatic Polypeptide Tumor / Recurrent Islet Cell Carcinoma / Somatostatinoma1
2Active Not RecruitingTreatmentColorectal Cancer Liver Metastases1
2Active Not RecruitingTreatmentColorectal Cancers2
2Active Not RecruitingTreatmentEsophageal Cancers / Malignant Neoplasm of Stomach2
2Active Not RecruitingTreatmentEstrogen Receptor Negative / HER2/Neu Negative / Progesterone Receptor Negative / Recurrent Breast Carcinoma / Stage III Breast Cancer / Stage IIIA Breast Cancer / Stage IIIB Breast Cancer / Stage IIIC Breast Cancer / Stage IV Breast Cancer / Triple-Negative Breast Carcinoma1
2Active Not RecruitingTreatmentGastric Adenocarcinoma / Neoplasms, Gastrointestinal1
2Active Not RecruitingTreatmentGastrinoma / Glucagonoma / Insulinoma / Pancreatic Polypeptide Tumor / Recurrent Islet Cell Carcinoma / Recurrent Pancreatic Cancer / Somatostatinoma / Stage III Pancreatic Cancer / Stage IV Pancreatic Cancer1
2Active Not RecruitingTreatmentGastroesophageal Junction Cancer / Malignant Neoplasm of Stomach1
2Active Not RecruitingTreatmentHER2/Neu Positive / Recurrent Breast Carcinoma / Stage IIIB Breast Cancer / Stage IIIB Breast Cancer AJCC v7 / Stage IIIC Breast Cancer / Stage IIIC Breast Cancer AJCC v7 / Stage IV Breast Cancer / Stage IV Breast Cancer AJCC v6 and v71
2Active Not RecruitingTreatmentHepatic Metastases / Rectal Carcinoma1
2Active Not RecruitingTreatmentHepatocellular,Carcinoma / Secondary1
2Active Not RecruitingTreatmentHer-2 Positive Gastric Cancer / Metastatic or Recurrent Gastric Adenocarcinoma1
2Active Not RecruitingTreatmentMalignant Neoplasm of Female Breast1
2Active Not RecruitingTreatmentMalignant Neoplasm of Pancreas6
2Active Not RecruitingTreatmentMalignant Neoplasm of Stomach3
2Active Not RecruitingTreatmentMalignant Tumor of the Breast / Neoplasms, Breast1
2Active Not RecruitingTreatmentMetastatic Colorectal Cancers1
2Active Not RecruitingTreatmentPancreatic Ductal Adenocarcinoma1
2Active Not RecruitingTreatmentRectal Adenocarcinoma / Stage II Rectal Cancer / Stage II Rectal Cancer AJCC v7 / Stage III Rectal Cancer / Stage III Rectal Cancer AJCC v71
2Active Not RecruitingTreatmentRectal Carcinoma2
2Active Not RecruitingTreatmentRecurrent Colorectal Carcinoma / Refractory Colorectal Carcinoma / Stage IV Colorectal Cancer / Stage IV Colorectal Cancer AJCC v7 / Stage IVA Colorectal Cancer / Stage IVA Colorectal Cancer AJCC v7 / Stage IVB Colorectal Cancer / Stage IVB Colorectal Cancer AJCC v71
2Active Not RecruitingTreatmentRecurrent Small Intestine Cancer / Small Intestine Adenocarcinoma1
2Active Not RecruitingTreatmentSquamous Cell Carcinoma (SCC) / Squamous Cell Carcinoma of Skin1
2Active Not RecruitingTreatmentMCRC1
2CompletedNot AvailableMetastatic Breast Cancer (MBC)1
2CompletedSupportive CareExtrahepatic Bile Duct Cancer / Nausea / Stage II Pancreatic Cancer / Stage III Pancreatic Cancer / Stage IV Pancreatic Cancer / Vomiting1
2CompletedTreatment70 Years Old Patients and Over / After One Line of Chemotherapy With Trastuzumab / Metastatic Breast Cancer (MBC)1
2CompletedTreatmentAdenocarcinoma Of Esophagus1
2CompletedTreatmentAdenocarcinoma of Colon / Adenocarcinoma of Rectum / Metastatic Disease1
2CompletedTreatmentAdenocarcinoma of the Cervix / Adenosquamous carcinoma of the cervix / Recurrent Cervical Carcinoma1
2CompletedTreatmentAdenocarcinoma of the Colon / Adenocarcinoma of the Rectum / Hepatic Metastases / Metastatic Colon Cancer / Recurrent Colon Cancer / Recurrent Rectal Cancer / Stage IV Rectal Cancer1
2CompletedTreatmentAdenocarcinoma of the Pancreas1
2CompletedTreatmentAdenocarcinoma of the Pancreas / Stage IA Pancreatic Cancer / Stage IB Pancreatic Cancer / Stage IIA Pancreatic Cancer / Stage IIB Pancreatic Cancer1
2CompletedTreatmentAdenocarcinoma of the Pancreas / Stage II Pancreatic Cancer / Stage III Pancreatic Cancer1
2CompletedTreatmentAdenocarcinomas of the Gastroesophageal Junction / Advanced Gastric Cancer / Diffuse Adenocarcinoma of the Stomach / Intestinal Adenocarcinoma of the Stomach / Mixed Adenocarcinoma of the Stomach / Recurrent Gastric Cancer / Stage IIIA Gastric Cancer / Stage IIIB Gastric Cancer / Stage IIIC Gastric Cancer1
2CompletedTreatmentAdenocarcinomas of the Gastroesophageal Junction / Esophageal Cancers1
2CompletedTreatmentAdvanced Breast Cancer / Cancer, Breast1
2CompletedTreatmentAdvanced Gastric Cancer3
2CompletedTreatmentAdvanced or Recurrent Esophageal Squamous Cell Carcinoma1
2CompletedTreatmentAdvanced/Metastatic Breast Cancer1
2CompletedTreatmentAnal Carcinoma1
2CompletedTreatmentAnal canal neoplasms malignant1
2CompletedTreatmentAnaplastic Glioma of Brain / Brain Cancer / Glioblastoma Multiforme (GBM)1
2CompletedTreatmentBiliary Tract Cancer2
2CompletedTreatmentBiliary Tract Cancer / Gallbladder Adenocarcinoma1
2CompletedTreatmentBiliary Tract Neoplasms1
2CompletedTreatmentBrain Stem Gliomas1
2CompletedTreatmentBreast Cancer Metastatic1
2CompletedTreatmentBreast Cancer, Gastric Cancer / Tumors, Solid1
2CompletedTreatmentCancer of the Biliary Tract / Cancer of the Gallbladder1
2CompletedTreatmentCancer of the Ovary1
2CompletedTreatmentCancer of the Ovary / Fallopian Tube Cancer / Primary Peritoneal Cavity Cancer1
2CompletedTreatmentCancer, Breast28
2CompletedTreatmentCancer, Breast / Elderly Patients1
2CompletedTreatmentCancer, Breast / Estrogen Receptor Positive Tumor1
2CompletedTreatmentCancer, Breast / Metastatic Breast Cancer (MBC) / Tumors, Solid1
2CompletedTreatmentCancer, Breast / Metastatic Cancers1
2CompletedTreatmentCancer, Breast / Neoplasms Metastasis2
2CompletedTreatmentCancer, Breast / Neoplasms, Breast1
2CompletedTreatmentCancers2
2CompletedTreatmentCarcinoid tumour of the gastrointestinal tract / Islet Cell Tumor1
2CompletedTreatmentCervical Cancers2
2CompletedTreatmentCholangiocarcinomas3
2CompletedTreatmentColorectal Adenocarcinoma1
2CompletedTreatmentColorectal Cancers32
2CompletedTreatmentColorectal Cancers / Malignant Neoplasm of Colon1
2CompletedTreatmentColorectal Cancers / Neoplasms Metastasis2
2CompletedTreatmentColorectal Cancers / Neoplasms, Colorectal1
2CompletedTreatmentERBB2 Gene Amplification / Neoplasms Metastasis / Stomach Neoplasms1
2CompletedTreatmentEffects of Chemotherapy / Malignant Neoplasm of Stomach1
2CompletedTreatmentEsophageal Cancers1
2CompletedTreatmentEsophageal Cancers / Malignant Neoplasm of Stomach3
2CompletedTreatmentEstrogen Receptor-negative Breast Cancer / Estrogen Receptor-Positive Breast Cancer / Her2-Positive Breast Cancer / Progesterone Receptor-negative Breast Cancer / Progesterone Receptor-positive Breast Cancer / Stage IA Breast Cancer / Stage IB Breast Cancer / Stage II Breast Cancer / Stage IIIA Breast Cancer1
2CompletedTreatmentExtrahepatic Bile Duct Cancer / Gallbladder Cancer3
2CompletedTreatmentGastric Carcinoma / Gastroesophageal Junction Carcinoma1
2CompletedTreatmentGastro Oesophageal Cancer1
2CompletedTreatmentGastroesophageal Junction Cancer / Malignant Neoplasm of Stomach1
2CompletedTreatmentGastroesophageal Junction Neoplasms / Stomach Neoplasms1
2CompletedTreatmentGastrointestinal Cancers3
2CompletedTreatmentHead and Neck Carcinoma3
2CompletedTreatmentHead and Neck Carcinoma / Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma / Recurrent Metastatic Squamous Neck Cancer With Occult Primary / Recurrent Salivary Gland Cancer / Recurrent Squamous Cell Carcinoma of the Hypopharynx / Recurrent Squamous Cell Carcinoma of the Larynx / Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity / Recurrent Squamous Cell Carcinoma of the Oropharynx / Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Recurrent Verrucous Carcinoma of the Larynx / Recurrent Verrucous Carcinoma of the Oral Cavity / Salivary Gland Squamous Cell Carcinoma / Stage IV Salivary Gland Cancer / Stage IV Squamous Cell Carcinoma of the Hypopharynx / Stage IV Squamous Cell Carcinoma of the Larynx / Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage IV Squamous Cell Carcinoma of the Oropharynx / Stage IV Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Stage IV Verrucous Carcinoma of the Larynx / Stage IV Verrucous Carcinoma of the Oral Cavity1
2CompletedTreatmentHead or Neck Cancer1
2CompletedTreatmentHepatocellular,Carcinoma2
2CompletedTreatmentLiver Cancer2
2CompletedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
2CompletedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC) / Lung Cancers1
2CompletedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC) / Neoplasms, Breast1
2CompletedTreatmentMale Breast Cancer / Recurrent Breast Cancer / Stage IV Breast Cancer1
2CompletedTreatmentMalignant Gliomas1
2CompletedTreatmentMalignant Neoplasm of Colon3
2CompletedTreatmentMalignant Neoplasm of Nasopharynx2
2CompletedTreatmentMalignant Neoplasm of Pancreas15
2CompletedTreatmentMalignant Neoplasm of Pancreas / Neoplasms Metastasis1
2CompletedTreatmentMalignant Neoplasm of Pancreas / Pancreatic Adenocarcinoma Metastatic1
2CompletedTreatmentMalignant Neoplasm of Stomach13
2CompletedTreatmentMesothelioma, Malignant1
2CompletedTreatmentMetastatic Adenocarcinoma of the Pancreas1
2CompletedTreatmentMetastatic Breast Cancer (MBC)7
2CompletedTreatmentMetastatic Breast Cancer (MBC) / Neoplasms, Breast1
2CompletedTreatmentMetastatic Colorectal Cancers12
2CompletedTreatmentMetastatic Renal Cell Carcinoma1
2CompletedTreatmentMetastatic gpNMB Over-expressing Triple Negative Breast Cancer1
2CompletedTreatmentNasopharyngeal Carcinoma1
2CompletedTreatmentNasopharyngeal Neoplasms1
2CompletedTreatmentNeoplasms1
2CompletedTreatmentNeoplasms Metastasis / Stomach Neoplasms1
2CompletedTreatmentNeoplasms, Breast2
2CompletedTreatmentNeoplasms, Colorectal3
2CompletedTreatmentNeoplasms, Gastrointestinal Tract1
2CompletedTreatmentNeoplasms, Kidney1
2CompletedTreatmentNeoplasms, Pancreatic1
2CompletedTreatmentNeuroendocrine Tumors2
2CompletedTreatmentNon Small Cell Lung Carcinoma (NSCLC)1
2CompletedTreatmentOesophageal Carcinoma1
2CompletedTreatmentPancreatic Cancer Metastatic2
2CompletedTreatmentPancreatic Cancer Stage IVA1
2CompletedTreatmentProstate Cancer4
2CompletedTreatmentRectal Carcinoma9
2CompletedTreatmentRectal Neoplasms5
2CompletedTreatmentRectal Tumour1
2CompletedTreatmentRectum Cancer1
2CompletedTreatmentRecurrent Breast Cancer / Stage IV Breast Cancer1
2CompletedTreatmentRenal Cancers2
2CompletedTreatmentRenal Cancers / Renal Cell Adenocarcinoma1
2CompletedTreatmentRenal Cell Adenocarcinoma2
2CompletedTreatmentResectable Rectal Cancer Clinical Stage II and III1
2CompletedTreatmentResected Advanced Gastric Cancer1
2CompletedTreatmentStage IA Pancreatic Cancer / Stage IB Pancreatic Cancer / Stage IIA Pancreatic Cancer / Stage IIB Pancreatic Cancer1
2CompletedTreatmentStage IV Gastric Cancer With Metastasis1
2CompletedTreatmentStomach Neoplasms2
2CompletedTreatmentThyroid Cancers1
2CompletedTreatmentTriple Negative Breast Cancer (TNBC)1
2CompletedTreatmentUnknown Primary Neoplasms1
2Enrolling by InvitationTreatmentBreastcancer / Cancer, Breast / Colorectal Cancer (CRC) / Colorectal Cancers / CRC (Colorectal Cancer) / Lung Cancer Non-Small Cell Cancer (NSCLC) / Lung Cancers / Malignant Neoplasm of Pancreas / NSCLC (Non-small Cell Lung Carcinoma)1
2Not Yet RecruitingTreatmentAdvanced Gastric Cancer1
2Not Yet RecruitingTreatmentBiliary Carcinoma1
2Not Yet RecruitingTreatmentBiliary Tract Cancer / Capecitabine / Chemotherapy, Adjuvant / Cholangiocarcinomas / Cisplatin / Gemcitabine1
2Not Yet RecruitingTreatmentCancer, Breast2
2Not Yet RecruitingTreatmentCapecitabine / Neuroendocrine Carcinomas / Neuroendocrine Tumors / Temozolomide1
2Not Yet RecruitingTreatmentHepatocellular,Carcinoma1
2Not Yet RecruitingTreatmentLeptomeningeal Disease / Metastatic Breast Cancer (MBC)1
2Not Yet RecruitingTreatmentMalignant Neoplasm of Colorectum1
2Not Yet RecruitingTreatmentMalignant Neoplasm of Female Breast1
2Not Yet RecruitingTreatmentMalignant Neoplasm of Female Breast / Triple Negative and Androgen Receptor Positive1
2Not Yet RecruitingTreatmentMalignant Neoplasm of Pancreas1
2Not Yet RecruitingTreatmentMalignant Neoplasm of Stomach1
2Not Yet RecruitingTreatmentMetastatic Colorectal Cancers1
2Not Yet RecruitingTreatmentPancreatic Cancer Metastatic1
2Not Yet RecruitingTreatmentStage II Breast Cancer / Stage III Breast Cancer1
2RecruitingNot AvailableRectal Carcinoma1
2RecruitingTreatmentAdenocarcinoma Of Esophagus / Adenocarcinomas of the Gastroesophageal Junction / Gastric Adenocarcinoma / Metastatic Esophagogastric Adenocarcinoma / Neoplasm, Gastric / Neoplasms, Esophageal / Unresectable, Locally Advanced or Metastatic, Adenocarcinoma of the Stomach, or of the Gastro Esophageal Junction1
2RecruitingTreatmentAdenocarcinoma of the Gastro-oesophageal Junction / Adenocarcinoma of the Oesophagus / Adenocarcinoma of the Stomach1
2RecruitingTreatmentAdenocarcinoma of the Pancreas / Recurrent Pancreatic Carcinoma / Stage I Pancreatic Cancer / Stage IA Pancreatic Cancer / Stage IB Pancreatic Cancer / Stage II Pancreatic Cancer / Stage IIA Pancreatic Cancer / Stage IIB Pancreatic Cancer / Stage III Pancreatic Cancer / Stage IV Pancreatic Cancer1
2RecruitingTreatmentAdenocarcinomas of the Esophagogastric Junction1
2RecruitingTreatmentAdenocarcinomas of the Gastroesophageal Junction1
2RecruitingTreatmentAdvanced Rectal Cancer1
2RecruitingTreatmentAnal Carcinoma1
2RecruitingTreatmentBile Duct Neoplasms / Cancer of Unknown Primary Site / Gastrointestinal Cancers / Malignant Neoplasm of Pancreas1
2RecruitingTreatmentBiliary Tract Cancer3
2RecruitingTreatmentBreast Cancer Metastatic1
2RecruitingTreatmentBreast Diseases / Capecitabine / HER2 Positive Breast Carcinoma / Her2-Positive Breast Cancer / Neoplasms, Breast1
2RecruitingTreatmentCancer, Breast5
2RecruitingTreatmentCancer, Breast / Gastrointestinal Cancers1
2RecruitingTreatmentCarcinoma, Colorectal / Colorectal Adenocarcinoma / Colorectal Cancers / Colorectal Tumors / Neoplasms, Colorectal1
2RecruitingTreatmentChemotherapy Effect / Colorectal Cancers / Intestinal Diseases / Intestinal Neoplasms / Neoplasms, Colorectal / Rectal Carcinoma / Rectal Neoplasms1
2RecruitingTreatmentColorectal Cancers1
2RecruitingTreatmentColorectal Large Cell Neuroendocrine Carcinoma / Esophageal Large Cell Neuroendocrine Carcinoma / Gallbladder Large Cell Neuroendocrine Carcinoma / Gastric Large Cell Neuroendocrine Carcinoma / Gastric Neuroendocrine Carcinoma / Intestinal Neuroendocrine Carcinoma / Pancreatic Large Cell Neuroendocrine Carcinoma / Pancreatic Neuroendocrine Carcinoma / Small Intestinal Large Cell Neuroendocrine Carcinoma1
2RecruitingTreatmentDrug Therapy / Radiations / Rectal Neoplasms1
2RecruitingTreatmentEpstein-Barr Virus Positive / Gastric Adenocarcinoma / Mismatch Repair Protein Deficiency / Stage IB Gastric Cancer AJCC v7 / Stage II Gastric Cancer AJCC v7 / Stage IIA Gastric Cancer AJCC v7 / Stage IIB Gastric Cancer AJCC v7 / Stage III Gastric Cancer AJCC v7 / Stage IIIA Gastric Cancer AJCC v7 / Stage IIIB Gastric Cancer AJCC v7 / Stage IIIC Gastric Cancer AJCC v71
2RecruitingTreatmentEsophageal Cancers / Malignant Neoplasm of Stomach1
2RecruitingTreatmentEsophageal, Gastric, or Gastroesophageal Junction Carcinoma1
2RecruitingTreatmentEsophagus Cancer / Malignant Neoplasm of Stomach1
2RecruitingTreatmentGastric Adenocarcinoma / Gastroesophageal-junction Adenocarcinoma1
2RecruitingTreatmentGastro Esophageal Junction Cancer / Malignant Neoplasm of Stomach1
2RecruitingTreatmentGastro-entero-pancreatic Neuroendocrine Tumors1
2RecruitingTreatmentGastrooesophageal Cancer / Malignant Neoplasm of Stomach1
2RecruitingTreatmentHER2 Positive Breast Cancers2
2RecruitingTreatmentHead and Neck Squamous Cell Carcinoma (HNSCC)1
2RecruitingTreatmentHepatocellular,Carcinoma1
2RecruitingTreatmentHer-2 Positive Gastric Cancer / Metastatic Cancers1
2RecruitingTreatmentHer2-Positive Breast Cancer / Recurrent Breast Cancer / Stage IV Breast Cancer1
2RecruitingTreatmentMalignant Neoplasm of Colon1
2RecruitingTreatmentMalignant Neoplasm of Pancreas3
2RecruitingTreatmentMalignant Neoplasm of Stomach3
2RecruitingTreatmentMetastatic Breast Cancer (MBC)2
2RecruitingTreatmentMetastatic Colorectal Cancers4
2RecruitingTreatmentMicrosatellite Stable / Mismatch Repair Protein Proficient / Stage III Colorectal Cancer AJCC v7 / Stage IIIB Colorectal Cancer AJCC v7 / Stage IIIC Colorectal Cancer AJCC v7 / Stage IV Colorectal Cancer AJCC v7 / Stage IVA Colorectal Cancer AJCC v7 / Stage IVB Colorectal Cancer AJCC v71
2RecruitingTreatmentMidgut Neuroendocrine Tumours / Progressive Neuroendocrine Tumors of pancreatic origin1
2RecruitingTreatmentNeoplasms, Colorectal3
2RecruitingTreatmentNeoplasms, Esophageal / Stomach Neoplasms1
2RecruitingTreatmentNeuroendocrine Carcinomas1
2RecruitingTreatmentNeuroendocrine Tumors1
2RecruitingTreatmentPancreatic Ductal Carcinoma / Resectable Pancreatic Cancers1
2RecruitingTreatmentRectal Adenocarcinoma2
2RecruitingTreatmentRectal Adenocarcinoma / Stage II Rectal Cancer / Stage II Rectal Cancer AJCC v7 / Stage III Rectal Cancer / Stage III Rectal Cancer AJCC v71
2RecruitingTreatmentRectal Carcinoma7
2RecruitingTreatmentTriple Negative Breast Cancer (TNBC)2
2RecruitingTreatmentUnresectable Pancreatic Cancer1
2SuspendedTreatmentMalignant Neoplasm of Stomach1
2TerminatedNot AvailableCarcinoma of Unknown Primary1
2TerminatedDiagnosticHead and Neck Carcinoma1
2TerminatedTreatmentAdenocarcinoma of the Pancreas / Stage III Pancreatic Cancer1
2TerminatedTreatmentAdenocarcinomas of the Gastroesophageal Junction / Malignant Neoplasm of Stomach1
2TerminatedTreatmentAdenocarcinomas / Carcinoma NOS / Rectal Neoplasms1
2TerminatedTreatmentAdenocarcinomas / Malignant Neoplasm of Colon1
2TerminatedTreatmentAdult Primary Hepatocellular Carcinoma / Advanced Adult Primary Liver Cancer / Localized Unresectable Adult Primary Liver Cancer / Recurrent Adult Primary Liver Cancer1
2TerminatedTreatmentAdvanced Breast Cancer / Cancer, Breast / HER2/Neu-positive Breast Cancer / Metastatic Breast Cancer (MBC)1
2TerminatedTreatmentAdvanced or Metastatic HER2-negative Breast Cancer / Cancer, Breast1
2TerminatedTreatmentBile Duct Carcinoma / Cancer of Gallbladder / Cholangiocarcinomas / Hepatobiliary Neoplasms / Liver Cancer1
2TerminatedTreatmentBiliary Cancer1
2TerminatedTreatmentBreast Cancer, Metastatic / Cancer treatment1
2TerminatedTreatmentCancer of the Ovary / Fallopian Tube Cancer / Peritoneal Cavity Cancer1
2TerminatedTreatmentCancer of the Ovary / Primary Peritoneal Cavity Cancer1
2TerminatedTreatmentCancer, Breast11
2TerminatedTreatmentCancer, Breast / Metastatic Cancers1
2TerminatedTreatmentCancers2
2TerminatedTreatmentCarcinoma of Anal Canal1
2TerminatedTreatmentColorectal Cancers7
2TerminatedTreatmentColorectal Cancers / Metastases1
2TerminatedTreatmentColorectal Cancers / Neoplasms Metastasis1
2TerminatedTreatmentDrug Therapy, Combination / Neoplasms, Colorectal / Secondary1
2TerminatedTreatmentEsophageal Cancers / Gastric Adenocarcinoma / Malignant Neoplasm of Stomach1
2TerminatedTreatmentEsophagus Cancer / Malignant Neoplasm of Colon / Malignant Neoplasm of Stomach / Rectum Cancer / Small Bowel Cancer1
2TerminatedTreatmentEstrogen Receptor-Positive Breast Cancer / HER2-Negative Breast Cancer / Progesterone Receptor-positive Breast Cancer / Stage I Breast Carcinoma / Stage II Breast Cancer / Stage IIIA Breast Cancer1
2TerminatedTreatmentGastric Adenocarcinoma1
2TerminatedTreatmentGastrooesophageal Cancer1
2TerminatedTreatmentHead and Neck Carcinoma1
2TerminatedTreatmentHepatic Metastases / Metastatic Colon Cancer / Recurrent Colon Cancer / Recurrent Rectal Cancer / Stage IV Rectal Cancer1
2TerminatedTreatmentHepatocellular Cancer / Liver Cancer1
2TerminatedTreatmentHepatocellular,Carcinoma2
2TerminatedTreatmentInvasive Breast Carcinoma / Primary Invasive Breast Cancer / Stage I Breast Carcinoma / Stage II Breast Cancer / Stage III Breast Cancer1
2TerminatedTreatmentKRAS Wild Type / Resectable Type II Gastric Adenocarcinoma1
2TerminatedTreatmentMalignant Neoplasm of Pancreas3
2TerminatedTreatmentMalignant Neoplasm of Stomach2
2TerminatedTreatmentMetastatic Breast Cancer (MBC)3
2TerminatedTreatmentMetastatic Colorectal Cancers5
2TerminatedTreatmentNeoplasms, Breast1
2TerminatedTreatmentNeoplasms, Breast / Relapsed Breast Cancer1
2TerminatedTreatmentNeoplasms, Colorectal4
2TerminatedTreatmentNeoplasms, Pancreatic1
2TerminatedTreatmentRectal Carcinoma3
2TerminatedTreatmentRecurrent Colon Carcinoma / Recurrent Rectal Carcinoma / Stage IVA Colon Cancer / Stage IVA Rectal Cancer / Stage IVB Colon Cancer / Stage IVB Rectal Cancer1
2TerminatedTreatmentRecurrent Skin Cancer / Squamous Cell Carcinoma of the Skin1
2TerminatedTreatmentTriple Negative Metastatic Breast Cancer1
2Unknown StatusTreatmentAdenocarcinoma Clear Cell1
2Unknown StatusTreatmentAdvanced Breast Cancer1
2Unknown StatusTreatmentAdvanced Colorectal Cancer1
2Unknown StatusTreatmentBone Metastases / Tumors, Solid1
2Unknown StatusTreatmentCancer, Breast4
2Unknown StatusTreatmentCancer, Breast / Metastasis2
2Unknown StatusTreatmentCholangiocarcinomas1
2Unknown StatusTreatmentColorectal Adenocarcinoma1
2Unknown StatusTreatmentColorectal Cancers9
2Unknown StatusTreatmentEsophageal Cancers1
2Unknown StatusTreatmentEsophageal Cancers / Malignant Neoplasm of Stomach1
2Unknown StatusTreatmentGastric (Stomach) Cancer / Gastrointestinal Stromal Tumors (GISTs) / Malignant Neoplasm of Stomach / Neoplasm of Cardioesophageal Junction1
2Unknown StatusTreatmentGastric Carcinoma1
2Unknown StatusTreatmentHead and Neck Carcinoma1
2Unknown StatusTreatmentHepatic Metastases / Metastatic Breast Cancer (MBC)2
2Unknown StatusTreatmentLocally Advanced Non-resectable Breast Cancer / Metastatic Breast Cancer (MBC)1
2Unknown StatusTreatmentLocally Advanced Rectal Cancer2
2Unknown StatusTreatmentLung Cancers1
2Unknown StatusTreatmentMalignant Neoplasm of Esophagus1
2Unknown StatusTreatmentMalignant Neoplasm of Pancreas2
2Unknown StatusTreatmentMalignant Neoplasm of Stomach5
2Unknown StatusTreatmentMetastatic Breast Cancer (MBC)2
2Unknown StatusTreatmentMetastatic Colorectal Cancers2
2Unknown StatusTreatmentNeoadjuvant Therapy / Rectal Neoplasms1
2Unknown StatusTreatmentNeoadjuvant Treatment / Rectal Neoplasms1
2Unknown StatusTreatmentNeoplasms Metastasis / Neoplasms, Colorectal1
2Unknown StatusTreatmentNeoplasms Metastasis / Rectal Carcinoma1
2Unknown StatusTreatmentNeoplasms, Breast1
2Unknown StatusTreatmentNeoplasms, Colorectal1
2Unknown StatusTreatmentNeoplasms, Colorectal / Neoplasms, Hepatic1
2Unknown StatusTreatmentNeuroendocrine Carcinomas1
2Unknown StatusTreatmentPancreatic Cancer Metastatic1
2Unknown StatusTreatmentParanasal Sinus Squamous Cell Carcinoma / Recurrent Hypopharyngeal Squamous Cell Carcinoma / Recurrent Laryngeal Squamous Cell Carcinoma / Recurrent Oral Cavity Squamous Cell Carcinoma / Recurrent Oropharyngeal Squamous Cell Carcinoma / Stage IVA Hypopharyngeal Squamous Cell Carcinoma / Stage IVA Laryngeal Squamous Cell Carcinoma / Stage IVA Oral Cavity Squamous Cell Carcinoma / Stage IVA Oropharyngeal Squamous Cell Carcinoma / Stage IVB Hypopharyngeal Squamous Cell Carcinoma / Stage IVB Laryngeal Squamous Cell Carcinoma / Stage IVB Oral Cavity Squamous Cell Carcinoma / Stage IVB Oropharyngeal Squamous Cell Carcinoma / Stage IVC Hypopharyngeal Squamous Cell Carcinoma / Stage IVC Laryngeal Squamous Cell Carcinoma / Stage IVC Oral Cavity Squamous Cell Carcinoma / Stage IVC Oropharyngeal Squamous Cell Carcinoma1
2Unknown StatusTreatmentRectal Carcinoma2
2Unknown StatusTreatmentStage T3-4NxM0 Gastric Cancer1
2Unknown StatusTreatmentStomach Neoplasms3
2WithdrawnTreatmentAdvanced or Metastatic Biliary Tract Cancer1
2WithdrawnTreatmentBiliary Tract Cancer1
2WithdrawnTreatmentCancer, Breast2
2WithdrawnTreatmentCarcinoma of Unknown Primary1
2WithdrawnTreatmentColorectal Cancers1
2WithdrawnTreatmentColorectal Cancers / Metastatic Cancers2
2WithdrawnTreatmentMetastatic Colorectal Cancers4
2WithdrawnTreatmentRectal Carcinoma / Rectal Neoplasms1
2WithdrawnTreatmentRecurrent Squamous Cell Carcinoma of the Hypopharynx / Recurrent Squamous Cell Carcinoma of the Larynx / Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity / Recurrent Squamous Cell Carcinoma of the Oropharynx / Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity1
2, 3Active Not RecruitingTreatmentColorectal Cancers1
2, 3Active Not RecruitingTreatmentMalignant Neoplasm of Stomach2
2, 3CompletedTreatmentCancer, Breast1
2, 3CompletedTreatmentMalignant Neoplasm of Pancreas1
2, 3CompletedTreatmentMetastatic Breast Cancer (MBC)1
2, 3CompletedTreatmentRectal Neoplasm Malignant1
2, 3Enrolling by InvitationTreatmentColorectal Cancers1
2, 3Not Yet RecruitingTreatmentAbdominal wall neoplasm / Carcinoma, Colorectal / Colorectal Cancers / Colorectal Tumors / Neoplasms, Colorectal / Peritoneal Diseases1
2, 3Not Yet RecruitingTreatmentCancer, Breast / Chemotherapy Effect / Disease-Free Survival1
2, 3Not Yet RecruitingTreatmentQuality of Life1
2, 3RecruitingPreventionGastric Cancer Stage IIIB / Gastric Cancer Stage IIIC1
2, 3RecruitingTreatmentAdenocarcinomas of the Gastroesophageal Junction1
2, 3RecruitingTreatmentBiliary Tract Cancer1
2, 3RecruitingTreatmentCancer, Breast1
2, 3RecruitingTreatmentColorectal Cancers2
2, 3RecruitingTreatmentMalignant Neoplasm of Esophagus1
2, 3RecruitingTreatmentMalignant Neoplasm of Pancreas1
2, 3RecruitingTreatmentOesophagogastric Cancer1
2, 3RecruitingTreatmentRectal Carcinoma1
2, 3TerminatedTreatmentCancer, Breast2
2, 3TerminatedTreatmentCancer, Breast / HER2 Positive Breast Cancers1
2, 3Unknown StatusDiagnosticColorectal Cancers1
2, 3Unknown StatusTreatmentC04.588.274.476.411.3071
2, 3Unknown StatusTreatmentCancer, Breast2
2, 3Unknown StatusTreatmentEsophageal Cancers1
2, 3Unknown StatusTreatmentHepatocellular,Carcinoma / Neoplasms Metastasis1
2, 3Unknown StatusTreatmentPancreatic Cancer Stage II / Pancreatic Cancer Stage III1
2, 3Unknown StatusTreatmentRectal Carcinoma1
3Active Not RecruitingTreatmentAdenocarcinomas of the Gastroesophageal Junction / Metastatic Gastric Adenocarcinoma1
3Active Not RecruitingTreatmentBorderline Ovarian Mucinous Tumor / Ovarian Mucinous Cystadenocarcinoma / Recurrent Fallopian Tube Carcinoma / Recurrent Ovarian Carcinoma / Stage IA Fallopian Tube Cancer / Stage IA Ovarian Cancer / Stage IB Fallopian Tube Cancer / Stage IB Ovarian Cancer / Stage IC Fallopian Tube Cancer / Stage IC Ovarian Cancer / Stage IIA Fallopian Tube Cancer / Stage IIA Ovarian Cancer / Stage IIB Fallopian Tube Cancer / Stage IIB Ovarian Cancer / Stage IIC Fallopian Tube Cancer / Stage IIC Ovarian Cancer / Stage IIIA Fallopian Tube Cancer / Stage IIIA Ovarian Cancer / Stage IIIB Fallopian Tube Cancer / Stage IIIB Ovarian Cancer / Stage IIIC Fallopian Tube Cancer / Stage IIIC Ovarian Cancer / Stage IV Fallopian Tube Cancer / Stage IV Ovarian Cancer1
3Active Not RecruitingTreatmentCRC1
3Active Not RecruitingTreatmentCancer of the Rectum1
3Active Not RecruitingTreatmentCancer, Breast6
3Active Not RecruitingTreatmentColorectal Cancers3
3Active Not RecruitingTreatmentDigestive System Neoplasms / Intestinal Neoplasms / Neoplasms Metastasis / Neoplasms, Colorectal / Neoplasms, Gastrointestinal1
3Active Not RecruitingTreatmentEffects of Chemotherapy / Effects of Radiation Therapy / General Surgery / Neoplasms, Colorectal1
3Active Not RecruitingTreatmentGastric Adenocarcinoma1
3Active Not RecruitingTreatmentHER2 Positive Metastatic Breast Cancers1
3Active Not RecruitingTreatmentHER2+ Metastatic Breast Cancer (MBC)1
3Active Not RecruitingTreatmentLocally Advanced Malignant Neoplasm / Malignant Neoplasm of Pancreas / Pancreatic Carcinoma Non-resectable1
3Active Not RecruitingTreatmentMalignant Neoplasm of Stomach3
3Active Not RecruitingTreatmentMetastatic Breast Cancer (MBC)1
3Active Not RecruitingTreatmentMetastatic Triple Negative Breast Cancer1
3Active Not RecruitingTreatmentNasopharyngeal Carcinoma1
3Active Not RecruitingTreatmentNasopharyngeal Neoplasms1
3Active Not RecruitingTreatmentNeoplasms, Gastrointestinal Tract1
3Active Not RecruitingTreatmentPancreatic Acinar Cell Carcinoma / Pancreatic Ductal Adenocarcinoma / Pancreatic Intraductal Papillary-Mucinous Neoplasm / Stage I Pancreatic Cancer AJCC v6 and v7 / Stage IA Pancreatic Cancer / Stage IA Pancreatic Cancer AJCC v6 and v7 / Stage IB Pancreatic Cancer / Stage IB Pancreatic Cancer AJCC v6 and v7 / Stage II Pancreatic Cancer AJCC v6 and v7 / Stage IIA Pancreatic Cancer / Stage IIA Pancreatic Cancer AJCC v6 and v7 / Stage IIB Pancreatic Cancer / Stage IIB Pancreatic Cancer AJCC v6 and v71
3Active Not RecruitingTreatmentUnresectable, Locally Advanced or Metastatic, Adenocarcinoma of the Stomach, or of the Gastro Esophageal Junction1
3CompletedTreatmentAdenocarcinomas1
3CompletedTreatmentAdvanced Colorectal Cancer1
3CompletedTreatmentAdverse Drug Events / Complications / Hospital Costs / Length of Stay / Quality of Life1
3CompletedTreatmentCancer of the Breast / Cancer, Breast / Neoplasms, Breast1
3CompletedTreatmentCancer, Breast22
3CompletedTreatmentCancer, Breast / Cancers1
3CompletedTreatmentCancer, Breast / Metastases2
3CompletedTreatmentColorectal Cancers18
3CompletedTreatmentColorectal Cancers / Metastases1
3CompletedTreatmentExtrahepatic Bile Duct Cancer / Gallbladder Cancer / Liver Cancer1
3CompletedTreatmentGeneral Surgery / Malignant Neoplasm of Stomach1
3CompletedTreatmentMalignant Neoplasm of Breast1
3CompletedTreatmentMalignant Neoplasm of Pancreas4
3CompletedTreatmentMalignant Neoplasm of Stomach5
3CompletedTreatmentMetastatic Brain Tumors1
3CompletedTreatmentMetastatic Breast Cancer (MBC)4
3CompletedTreatmentMetastatic Colorectal Cancers1
3CompletedTreatmentNeoplasms, Breast2
3CompletedTreatmentNeoplasms, Pancreatic1
3CompletedTreatmentRectal Carcinoma1
3CompletedTreatmentStomach Neoplasms1
3Enrolling by InvitationTreatmentAnus Diseases / Anus Neoplasms / Carcinoma NOS / Neoplasms / Neoplasms, Squamous Cell / Squamous Cell Carcinoma (SCC)1
3Not Yet RecruitingPreventionIntraperitoneal Rectal Cancer / Malignant Neoplasm of Colon1
3Not Yet RecruitingTreatmentAdenocarcinomas of the Gastroesophageal Junction / Neoplasm, Gastric1
3Not Yet RecruitingTreatmentChemotherapy Effect / Susceptibility, Genetic1
3Not Yet RecruitingTreatmentColorectal Adenocarcinoma / RAS Wild Type / Stage III Colorectal Cancer AJCC v7 / Stage IIIA Colorectal Cancer AJCC v7 / Stage IIIB Colorectal Cancer AJCC v7 / Stage IIIC Colorectal Cancer AJCC v7 / Stage IV Colorectal Cancer AJCC v7 / Stage IVA Colorectal Cancer AJCC v7 / Stage IVB Colorectal Cancer AJCC v71
3Not Yet RecruitingTreatmentGastric Carcinoma1
3Not Yet RecruitingTreatmentHER2-Negative Breast Cancer / Leptomeningeal Carcinomatosis / Leptomeningeal Metastases / Metastatic Brain Tumors1
3Not Yet RecruitingTreatmentLocally Advanced Unresectable Gastric Adenocarcinoma or Cancer / Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer / Metastatic Gastric Adenocarcinoma or Cancer / Metastatic Gastroesophageal Junction (GEJ) Adenocarcinoma1
3Not Yet RecruitingTreatmentNasopharyngeal Carcinoma3
3Not Yet RecruitingTreatmentRectal Neoplasms1
3Not Yet RecruitingTreatmentStage I Gallbladder Cancer AJCC v8 / Stage II Gallbladder Cancer AJCC v8 / Stage IIA Gallbladder Cancer AJCC v8 / Stage IIB Gallbladder Cancer AJCC v8 / Stage III Gallbladder Cancer AJCC v8 / Stage IIIA Gallbladder Cancer AJCC v8 / Stage IIIB Gallbladder Cancer AJCC v81
3RecruitingPreventionChemotherapy Induced Neutropenia / Colorectal Cancers1
3RecruitingPreventionCholangiocarcinomas1
3RecruitingPreventionMalignant Neoplasm of Stomach1
3RecruitingSupportive CareRectal Carcinoma1
3RecruitingTreatmentAdvanced Gastric Cancer1
3RecruitingTreatmentAdvanced Rectal Cancer1
3RecruitingTreatmentBreast Cancer Model / Cancer, Breast / Effects of Chemotherapy1
3RecruitingTreatmentBreast Diseases / Neoplasms by Site / Neoplasms Metastasis / Neoplasms, Breast / Skin Diseases1
3RecruitingTreatmentBreast Neoplasm Female1
3RecruitingTreatmentCancer, Breast7
3RecruitingTreatmentChemotherapy, Adjuvant / Colorectal Cancer Stage III1
3RecruitingTreatmentCholangiocarcinomas / Gall Bladder Carcinoma1
3RecruitingTreatmentEstrogen Receptor Negative / HER2/Neu Negative / Invasive Breast Carcinoma / Progesterone Receptor Negative / Stage II Breast Cancer / Stage IIA Breast Cancer / Stage IIB Breast Cancer / Stage III Breast Cancer / Stage IIIA Breast Cancer / Stage IIIB Breast Cancer / Stage IIIC Breast Cancer / Triple-Negative Breast Carcinoma1
3RecruitingTreatmentGastric Cancer, Adjuvant Chemotherapy, XO1
3RecruitingTreatmentGastroesophageal Junction Cancer / Malignant Neoplasm of Stomach2
3RecruitingTreatmentHER-2 Positive Breast Cancer / Neoplasms, Metastatic1
3RecruitingTreatmentHER2-positive Locally Advanced or Metastatic Breast Cancer1
3RecruitingTreatmentLocally Advanced Colorectal Cancer1
3RecruitingTreatmentLocally Advanced Rectal Cancer1
3RecruitingTreatmentLocally Advanced Unresectable Gastric Cancer / Metastatic Gastric Cancers1
3RecruitingTreatmentMalignant Neoplasm Other Gallbladder/Extrahepatic Bile Duct1
3RecruitingTreatmentMalignant Neoplasm of Colon2
3RecruitingTreatmentMalignant Neoplasm of Pancreas1
3RecruitingTreatmentMalignant Neoplasm of Stomach6
3RecruitingTreatmentMetastatic Breast Cancer (MBC)2
3RecruitingTreatmentMetastatic Colorectal Cancers1
3RecruitingTreatmentNasopharyngeal Carcinoma3
3RecruitingTreatmentNeoplasms, Colorectal1
3RecruitingTreatmentNeoplasms, Esophageal / Stage III Esophageal Squamous Cell Carcinoma1
3RecruitingTreatmentRectal Carcinoma3
3RecruitingTreatmentRectal Neoplasms2
3RecruitingTreatmentResected Pancreatic Adenocarcinoma1
3RecruitingTreatmentStage II Esophageal Squamous Cell Carcinoma / Stage III Esophageal Squamous Cell Carcinoma2
3RecruitingTreatmentStomach Neoplasms2
3RecruitingTreatmentTriple Negative Breast Neoplasms1
3TerminatedSupportive CareCancer, Breast / Colorectal Cancers / Pain1
3TerminatedTreatmentAdenocarcinoma of the Colon / Adenocarcinoma of the Rectum / Metastatic Colon Cancer / Recurrent Colon Cancer / Recurrent Rectal Cancer / Stage III Colon Cancer / Stage III Rectal Cancer / Stage IV Rectal Cancer1
3TerminatedTreatmentAdvanced Non-Small Cell Lung Cancer1
3TerminatedTreatmentCancer, Breast2
3TerminatedTreatmentCognitive/Functional Effects / Colorectal Cancers / Neurotoxicity1
3TerminatedTreatmentColorectal Cancers / Hepatic Metastases1
3TerminatedTreatmentColorectal Cancers / Metastatic Cancers1
3TerminatedTreatmentExtrahepatic Bile Duct Cancer / Gallbladder Cancer / Liver Cancer1
3TerminatedTreatmentGastric Carcinoma Stage IV1
3TerminatedTreatmentMalignant Neoplasm of Pancreas / Metastatic Pancreatic Adenocarcinoma That is Recurrent1
3TerminatedTreatmentMalignant Neoplasm of Pancreas / Pancreatic Adenocarcinoma Metastatic1
3TerminatedTreatmentMalignant Neoplasm of Stomach3
3TerminatedTreatmentMetastatic Breast Cancer (MBC)2
3TerminatedTreatmentMetastatic Colorectal Cancers1
3TerminatedTreatmentMucinous Adenocarcinoma of the Rectum / Recurrent Rectal Cancer / Signet Ring Adenocarcinoma of the Rectum / Stage IIA Rectal Cancer / Stage IIB Rectal Cancer / Stage IIC Rectal Cancer / Stage IIIA Rectal Cancer / Stage IIIB Rectal Cancer / Stage IIIC Rectal Cancer / Stage IVA Rectal Cancer / Stage IVB Rectal Cancer1
3TerminatedTreatmentNeoplasms, Breast1
3TerminatedTreatmentOesophago-gastric Cancer1
3TerminatedTreatmentRenal Cell Adenocarcinoma1
3Unknown StatusTreatmentCancer, Breast1
3Unknown StatusTreatmentColorectal Cancers5
3Unknown StatusTreatmentColorectal Cancers / Metastatic Cancers1
3Unknown StatusTreatmentColorectal Cancers / Resectable Liver Metastasis1
3Unknown StatusTreatmentHepatic Metastases / Neoplasms, Colorectal1
3Unknown StatusTreatmentMalignant Neoplasm of Pancreas1
3Unknown StatusTreatmentMalignant Neoplasm of Stomach1
3Unknown StatusTreatmentMetastatic Breast Cancer (MBC)1
3Unknown StatusTreatmentMetastatic Colorectal Cancers2
3WithdrawnTreatmentHepatic neoplasms malignant1
4Approved for MarketingNot AvailableNeoplasms, Breast1
4CompletedBasic ScienceAdenocarcinoma of the Pancreas1
4CompletedDiagnosticCancer, Breast / Colorectal Cancers1
4CompletedOtherHER2/Neu-negative Carcinoma of Breast / Hormone Receptor Positive Malignant Neoplasm of Breast / Recurrent Breast Cancer1
4CompletedTreatmentCancer, Breast2
4CompletedTreatmentColorectal Cancers5
4CompletedTreatmentColorectal Cancers / Neoplasms, Colorectal1
4CompletedTreatmentUpper Gastrointestinal Tumours1
4Not Yet RecruitingBasic ScienceCancer, Breast / Colorectal Cancers1
4TerminatedBasic ScienceAdenocarcinoma of the Stomach1
4TerminatedTreatmentCancer, Breast1
4TerminatedTreatmentColorectal Cancers1
4Unknown StatusTreatmentLiver Metastasis / Malignant Neoplasm of Stomach1
Not AvailableActive Not RecruitingNot AvailableCancers1
Not AvailableCompletedNot AvailableBiomarkers / Chemotherapy Effect / Metastatic Colorectal Cancers1
Not AvailableCompletedNot AvailableBreast Cancer, Colorectal Cancer, Gastric Cancer1
Not AvailableCompletedNot AvailableCancer, Breast3
Not AvailableCompletedNot AvailableCancer, Breast / Metastatic Cancers1
Not AvailableCompletedNot AvailableColorectal Cancers4
Not AvailableCompletedNot AvailableMalignant Neoplasm of Colon / Metastatic Breast Cancer (MBC) / Metastatic Breast Cancer, Colon Cancer1
Not AvailableCompletedBasic ScienceBMI >30 kg/m2 / Neoplasms1
Not AvailableCompletedTreatmentCancer, Breast2
Not AvailableCompletedTreatmentCancer, Breast / Stage I Breast Carcinoma / Stage II Breast Cancer / Stage IIIA Breast Cancer1
Not AvailableCompletedTreatmentCancers / Colonic Diseases1
Not AvailableCompletedTreatmentMetastatic Colorectal Cancers1
Not AvailableCompletedTreatmentNeoplasms1
Not AvailableCompletedTreatmentTumors, Solid1
Not AvailableCompletedTreatmentUnspecified Adult Solid Tumor, Protocol Specific1
Not AvailableNot Yet RecruitingNot AvailableCancer of Lymph Node / Stomach Neoplasms1
Not AvailableNot Yet RecruitingTreatmentNeoadjuvant Chemoradiation / Rectal Cancer, Adenocarcinoma1
Not AvailableRecruitingNot AvailableCancer, Breast1
Not AvailableRecruitingNot AvailableColorectal Cancers1
Not AvailableRecruitingNot AvailableElderly Metastatic Colorectal Cancer Patients1
Not AvailableRecruitingNot AvailableMetastatic Gastric Cancers1
Not AvailableRecruitingTreatmentAdenocarcinomas1
Not AvailableRecruitingTreatmentCancer, Breast2
Not AvailableRecruitingTreatmentRectal Carcinoma1
Not AvailableRecruitingTreatmentRecurrent Rectal Cancer1
Not AvailableTerminatedNot AvailableCancer, Breast1
Not AvailableTerminatedTreatmentAdenocarcinoma Of Esophagus1
Not AvailableTerminatedTreatmentEsophageal Cancers / Malignant Neoplasm of Stomach1
Not AvailableTerminatedTreatmentMalignant Neoplasm of Pancreas2
Not AvailableUnknown StatusNot AvailableRectal Carcinoma1
Not AvailableUnknown StatusTreatmentHilar Cholangiocarcinoma / Primary Sclerosing Cholangitis (PSC)1
Not AvailableUnknown StatusTreatmentMetastatic Colorectal Cancers1
Not AvailableUnknown StatusTreatmentNasopharyngeal Neoplasms1
Not AvailableWithdrawnTreatmentMalignant Neoplasm of Pancreas1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
  • Dept Health Central Pharmacy
  • F Hoffmann-La Roche Ltd.
  • Physicians Total Care Inc.
Dosage forms
FormRouteStrength
TabletOral150 mg/1
TabletOral500 mg/1
Tablet, film coatedOral150 mg
Tablet, film coatedOral300 mg
Tablet, film coatedOral500 mg
TabletOral150 mg
TabletOral500 mg
Tablet, film coatedOral150 mg/1
Tablet, film coatedOral500 mg/1
Prices
Unit descriptionCostUnit
Xeloda 500 mg tablet28.97USD tablet
Xeloda 150 mg tablet8.69USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5472949No1993-12-142013-12-14Us
US4966891No1994-01-132011-01-13Us
CA2103324No1997-12-232013-11-17Canada
CA1327358No1994-03-012011-03-01Canada

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)110-121 °CNot Available
water solubility26 mg/mLNot Available
logP0.4Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.248 mg/mLALOGPS
logP1.17ALOGPS
logP0.77ChemAxon
logS-3.2ALOGPS
pKa (Strongest Acidic)8.23ChemAxon
pKa (Strongest Basic)-3.6ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area120.69 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity82.75 m3·mol-1ChemAxon
Polarizability35.81 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9513
Blood Brain Barrier+0.6064
Caco-2 permeable-0.7096
P-glycoprotein substrateSubstrate0.5106
P-glycoprotein inhibitor INon-inhibitor0.8234
P-glycoprotein inhibitor IINon-inhibitor0.7514
Renal organic cation transporterNon-inhibitor0.9654
CYP450 2C9 substrateNon-substrate0.7999
CYP450 2D6 substrateNon-substrate0.864
CYP450 3A4 substrateNon-substrate0.5
CYP450 1A2 substrateNon-inhibitor0.7523
CYP450 2C9 inhibitorNon-inhibitor0.7673
CYP450 2D6 inhibitorNon-inhibitor0.8612
CYP450 2C19 inhibitorNon-inhibitor0.6569
CYP450 3A4 inhibitorNon-inhibitor0.7404
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8484
Ames testNon AMES toxic0.6521
CarcinogenicityNon-carcinogens0.8754
BiodegradationNot ready biodegradable0.9964
Rat acute toxicity2.4690 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9759
hERG inhibition (predictor II)Non-inhibitor0.7124
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-QFT , negativeLC-MS/MSsplash10-0a4i-0109000000-c0c4de3c4233af3f34d4
LC-MS/MS Spectrum - LC-ESI-QFT , negativeLC-MS/MSsplash10-0udi-0901000000-676f6925c6c255f4dd24
LC-MS/MS Spectrum - LC-ESI-QFT , negativeLC-MS/MSsplash10-0udi-0900000000-236cb917e50b215b9bd1
LC-MS/MS Spectrum - LC-ESI-QFT , negativeLC-MS/MSsplash10-0udi-1900000000-f06b7309e7a2ebfb3bde
LC-MS/MS Spectrum - LC-ESI-QFT , negativeLC-MS/MSsplash10-0ufr-3900000000-6bb1981f61b4205a9991
LC-MS/MS Spectrum - LC-ESI-QFT , negativeLC-MS/MSsplash10-0kdi-6900000000-ac9a56401938b72ae4f1
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-0a4i-0309000000-feac9f5163221adf2a7d
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-0udj-0912000000-258b837e7c98d16aafbf
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-0udi-0900000000-db3e2d6a5526611d6a6e
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-0udi-0900000000-b792e6750d1eaccca7aa
LC-MS/MS Spectrum - LC-ESI-QFT , negativeLC-MS/MSsplash10-0pb9-0609000000-cd05885e7f4f8d1853ec
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0006-0090000000-8029f6bc09ef7062240e
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-006x-0590000000-8cea6a9f156f58ccb593
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-00e9-0920000000-e942daf2b25f1829bec1
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0089-0900000000-2a5dcf8bb6ff7ae6d72f
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-001i-0900000000-460a3e3f1f8b25687c86
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0006-0090000000-6105bf5c619fbe72100a
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-001i-0900000000-af842efa254483370f53
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-001i-1900000000-61c84595e7254f9493c9
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-001i-0900000000-25912e0277815dec7dfc
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-001i-0900000000-f992985efa9f7da2dbba
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0006-0090000000-6ec0fa0ed4f779ff959a
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0006-0090000000-3be9f054ad6d351dfcda
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-007o-0960000000-eeaa7c678c405b7f7e1f

Taxonomy

Description
This compound belongs to the class of organic compounds known as 5'-deoxyribonucleosides. These are nucleosides in which the oxygen atom at the 5'position of the ribose moiety has been replaced by another atom. The nucleobases here are limited to purine, pyrimidine, and pyridine derivatives.
Kingdom
Organic compounds
Super Class
Nucleosides, nucleotides, and analogues
Class
5'-deoxyribonucleosides
Sub Class
Not Available
Direct Parent
5'-deoxyribonucleosides
Alternative Parents
Glycosylamines / Pyrimidones / Halopyrimidines / Aryl fluorides / Hydropyrimidines / Tetrahydrofurans / Heteroaromatic compounds / Secondary alcohols / 1,2-diols / Propargyl-type 1,3-dipolar organic compounds
show 8 more
Substituents
5'-deoxyribonucleoside / Glycosyl compound / N-glycosyl compound / Halopyrimidine / Pyrimidone / Aryl fluoride / Aryl halide / Pyrimidine / Hydropyrimidine / Heteroaromatic compound
show 20 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
organofluorine compound, carbamate ester, cytidines (CHEBI:31348)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Thymidylate synthase activity
Specific Function
Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
Gene Name
TYMS
Uniprot ID
P04818
Uniprot Name
Thymidylate synthase
Molecular Weight
35715.65 Da
References
  1. Patel A, Pluim T, Helms A, Bauer A, Tuttle RM, Francis GL: Enzyme expression profiles suggest the novel tumor-activated fluoropyrimidine carbamate capecitabine (Xeloda) might be effective against papillary thyroid cancers of children and young adults. Cancer Chemother Pharmacol. 2004 May;53(5):409-14. [PubMed:15132128]
  2. Eliason JF, Megyeri A: Potential for predicting toxicity and response of fluoropyrimidines in patients. Curr Drug Targets. 2004 May;5(4):383-8. [PubMed:15134221]
  3. Carlini LE, Meropol NJ, Bever J, Andria ML, Hill T, Gold P, Rogatko A, Wang H, Blanchard RL: UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan. Clin Cancer Res. 2005 Feb 1;11(3):1226-36. [PubMed:15709193]
  4. Li KM, Rivory LP, Clarke SJ: Rapid quantitation of plasma 2'-deoxyuridine by high-performance liquid chromatography/atmospheric pressure chemical ionization mass spectrometry and its application to pharmacodynamic studies in cancer patients. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Jun 5;820(1):121-30. Epub 2005 Apr 19. [PubMed:15866500]
  5. Fischel JL, Ciccolini J, Formento P, Ferrero JM, Milano G: Synergistic cytotoxic interaction in hormone-refractory prostate cancer with the triple combination docetaxel-erlotinib and 5-fluoro-5'-deoxyuridine. Anticancer Drugs. 2006 Aug;17(7):807-13. [PubMed:16926630]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
2. DNA
Kind
Nucleotide
Organism
Human
Pharmacological action
Yes
Actions
Incorporation into and destabilization
General Function:
Used for biological information storage.
Specific Function:
DNA contains the instructions needed for an organism to develop, survive and reproduce.
Molecular Weight:
2.15 x 1012 Da
References
  1. Walko CM, Lindley C: Capecitabine: a review. Clin Ther. 2005 Jan;27(1):23-44. [PubMed:15763604]
  2. Thomas DM, Zalcberg JR: 5-fluorouracil: a pharmacological paradigm in the use of cytotoxics. Clin Exp Pharmacol Physiol. 1998 Nov;25(11):887-95. [PubMed:9807659]
  3. Wyatt MD, Wilson DM 3rd: Participation of DNA repair in the response to 5-fluorouracil. Cell Mol Life Sci. 2009 Mar;66(5):788-99. doi: 10.1007/s00018-008-8557-5. [PubMed:18979208]
  4. Ghoshal K, Jacob ST: An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug. Biochem Pharmacol. 1997 Jun 1;53(11):1569-75. [PubMed:9264308]
  5. Longley DB, Harkin DP, Johnston PG: 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer. 2003 May;3(5):330-8. [PubMed:12724731]
  6. Petty RD, Cassidy J: Novel fluoropyrimidines: improving the efficacy and tolerability of cytotoxic therapy. Curr Cancer Drug Targets. 2004 Mar;4(2):191-204. [PubMed:15032669]
3. RNA
Kind
Nucleotide
Organism
Human
Pharmacological action
Yes
Actions
Incorporation into and destabilization
References
  1. Walko CM, Lindley C: Capecitabine: a review. Clin Ther. 2005 Jan;27(1):23-44. [PubMed:15763604]
  2. Thomas DM, Zalcberg JR: 5-fluorouracil: a pharmacological paradigm in the use of cytotoxics. Clin Exp Pharmacol Physiol. 1998 Nov;25(11):887-95. [PubMed:9807659]
  3. Wyatt MD, Wilson DM 3rd: Participation of DNA repair in the response to 5-fluorouracil. Cell Mol Life Sci. 2009 Mar;66(5):788-99. doi: 10.1007/s00018-008-8557-5. [PubMed:18979208]
  4. Ghoshal K, Jacob ST: An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug. Biochem Pharmacol. 1997 Jun 1;53(11):1569-75. [PubMed:9264308]
  5. Longley DB, Harkin DP, Johnston PG: 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer. 2003 May;3(5):330-8. [PubMed:12724731]
  6. Petty RD, Cassidy J: Novel fluoropyrimidines: improving the efficacy and tolerability of cytotoxic therapy. Curr Cancer Drug Targets. 2004 Mar;4(2):191-204. [PubMed:15032669]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Transferase activity, transferring pentosyl groups
Specific Function
May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in v...
Gene Name
TYMP
Uniprot ID
P19971
Uniprot Name
Thymidine phosphorylase
Molecular Weight
49954.965 Da
References
  1. de Bono JS, Twelves CJ: The oral fluorinated pyrimidines. Invest New Drugs. 2001;19(1):41-59. [PubMed:11291832]
  2. Tsukamoto Y, Kato Y, Ura M, Horii I, Ishitsuka H, Kusuhara H, Sugiyama Y: A physiologically based pharmacokinetic analysis of capecitabine, a triple prodrug of 5-FU, in humans: the mechanism for tumor-selective accumulation of 5-FU. Pharm Res. 2001 Aug;18(8):1190-202. [PubMed:11587492]
  3. Blanquicett C, Gillespie GY, Nabors LB, Miller CR, Bharara S, Buchsbaum DJ, Diasio RB, Johnson MR: Induction of thymidine phosphorylase in both irradiated and shielded, contralateral human U87MG glioma xenografts: implications for a dual modality treatment using capecitabine and irradiation. Mol Cancer Ther. 2002 Oct;1(12):1139-45. [PubMed:12481438]
  4. Ishitsuka H, Shimma N, Horii I: [Discovery and development of novel anticancer drug capecitabine]. Yakugaku Zasshi. 1999 Dec;119(12):881-97. [PubMed:10630095]
  5. Ishitsuka H: Capecitabine: preclinical pharmacology studies. Invest New Drugs. 2000 Nov;18(4):343-54. [PubMed:11081570]
  6. Endo M, Miwa M, Eda H, Ura M, Tanimura H, Ishikawa T, Miyazaki-Nose T, Hattori K, Shimma N, Yamada-Okabe H, Ishitsuka H: Augmentation of the antitumor activity of capecitabine by a tumor selective dihydropyrimidine dehydrogenase inhibitor, RO0094889. Int J Cancer. 2003 Sep 20;106(5):799-805. [PubMed:12866042]
  7. Schuller J, Cassidy J, Dumont E, Roos B, Durston S, Banken L, Utoh M, Mori K, Weidekamm E, Reigner B: Preferential activation of capecitabine in tumor following oral administration to colorectal cancer patients. Cancer Chemother Pharmacol. 2000;45(4):291-7. [PubMed:10755317]
  8. Patel A, Pluim T, Helms A, Bauer A, Tuttle RM, Francis GL: Enzyme expression profiles suggest the novel tumor-activated fluoropyrimidine carbamate capecitabine (Xeloda) might be effective against papillary thyroid cancers of children and young adults. Cancer Chemother Pharmacol. 2004 May;53(5):409-14. [PubMed:15132128]
  9. Eliason JF, Megyeri A: Potential for predicting toxicity and response of fluoropyrimidines in patients. Curr Drug Targets. 2004 May;5(4):383-8. [PubMed:15134221]
  10. Fischel JL, Ciccolini J, Formento P, Ferrero JM, Milano G: Synergistic cytotoxic interaction in hormone-refractory prostate cancer with the triple combination docetaxel-erlotinib and 5-fluoro-5'-deoxyuridine. Anticancer Drugs. 2006 Aug;17(7):807-13. [PubMed:16926630]
  11. Walko CM, Lindley C: Capecitabine: a review. Clin Ther. 2005 Jan;27(1):23-44. [PubMed:15763604]
  12. Ranieri G, Roccaro AM, Vacca A, Ribatti D: Thymidine phosphorylase (platelet-derived endothelial cell growth factor) as a target for capecitabine: from biology to the bedside. Recent Pat Anticancer Drug Discov. 2006 Jun;1(2):171-83. [PubMed:18221035]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Triglyceride lipase activity
Specific Function
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acy...
Gene Name
CES1
Uniprot ID
P23141
Uniprot Name
Liver carboxylesterase 1
Molecular Weight
62520.62 Da
References
  1. de Bono JS, Twelves CJ: The oral fluorinated pyrimidines. Invest New Drugs. 2001;19(1):41-59. [PubMed:11291832]
  2. Tsukamoto Y, Kato Y, Ura M, Horii I, Ishitsuka H, Kusuhara H, Sugiyama Y: A physiologically based pharmacokinetic analysis of capecitabine, a triple prodrug of 5-FU, in humans: the mechanism for tumor-selective accumulation of 5-FU. Pharm Res. 2001 Aug;18(8):1190-202. [PubMed:11587492]
  3. Ishitsuka H, Shimma N, Horii I: [Discovery and development of novel anticancer drug capecitabine]. Yakugaku Zasshi. 1999 Dec;119(12):881-97. [PubMed:10630095]
  4. Ishitsuka H: Capecitabine: preclinical pharmacology studies. Invest New Drugs. 2000 Nov;18(4):343-54. [PubMed:11081570]
  5. Endo M, Miwa M, Eda H, Ura M, Tanimura H, Ishikawa T, Miyazaki-Nose T, Hattori K, Shimma N, Yamada-Okabe H, Ishitsuka H: Augmentation of the antitumor activity of capecitabine by a tumor selective dihydropyrimidine dehydrogenase inhibitor, RO0094889. Int J Cancer. 2003 Sep 20;106(5):799-805. [PubMed:12866042]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Protein homodimerization activity
Specific Function
Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
Gene Name
DPYD
Uniprot ID
Q12882
Uniprot Name
Dihydropyrimidine dehydrogenase [NADP(+)]
Molecular Weight
111400.32 Da
References
  1. Tsukamoto Y, Kato Y, Ura M, Horii I, Ishitsuka H, Kusuhara H, Sugiyama Y: A physiologically based pharmacokinetic analysis of capecitabine, a triple prodrug of 5-FU, in humans: the mechanism for tumor-selective accumulation of 5-FU. Pharm Res. 2001 Aug;18(8):1190-202. [PubMed:11587492]
  2. Blanquicett C, Gillespie GY, Nabors LB, Miller CR, Bharara S, Buchsbaum DJ, Diasio RB, Johnson MR: Induction of thymidine phosphorylase in both irradiated and shielded, contralateral human U87MG glioma xenografts: implications for a dual modality treatment using capecitabine and irradiation. Mol Cancer Ther. 2002 Oct;1(12):1139-45. [PubMed:12481438]
  3. de Bono JS, Twelves CJ: The oral fluorinated pyrimidines. Invest New Drugs. 2001;19(1):41-59. [PubMed:11291832]
  4. Gross E, Seck K, Neubauer S, Mayr J, Hellebrand H, Ratanaphan A, Lutz V, Stockinger H, Kiechle M: High-throughput genotyping by DHPLC of the dihydropyrimidine dehydrogenase gene implicated in (fluoro)pyrimidine catabolism. Int J Oncol. 2003 Feb;22(2):325-32. [PubMed:12527930]
  5. Ishitsuka H: Capecitabine: preclinical pharmacology studies. Invest New Drugs. 2000 Nov;18(4):343-54. [PubMed:11081570]
  6. Endo M, Miwa M, Eda H, Ura M, Tanimura H, Ishikawa T, Miyazaki-Nose T, Hattori K, Shimma N, Yamada-Okabe H, Ishitsuka H: Augmentation of the antitumor activity of capecitabine by a tumor selective dihydropyrimidine dehydrogenase inhibitor, RO0094889. Int J Cancer. 2003 Sep 20;106(5):799-805. [PubMed:12866042]
  7. Patel A, Pluim T, Helms A, Bauer A, Tuttle RM, Francis GL: Enzyme expression profiles suggest the novel tumor-activated fluoropyrimidine carbamate capecitabine (Xeloda) might be effective against papillary thyroid cancers of children and young adults. Cancer Chemother Pharmacol. 2004 May;53(5):409-14. [PubMed:15132128]
  8. Eliason JF, Megyeri A: Potential for predicting toxicity and response of fluoropyrimidines in patients. Curr Drug Targets. 2004 May;5(4):383-8. [PubMed:15134221]
  9. Walko CM, Lindley C: Capecitabine: a review. Clin Ther. 2005 Jan;27(1):23-44. [PubMed:15763604]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Zinc ion binding
Specific Function
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
Gene Name
CDA
Uniprot ID
P32320
Uniprot Name
Cytidine deaminase
Molecular Weight
16184.545 Da
References
  1. de Bono JS, Twelves CJ: The oral fluorinated pyrimidines. Invest New Drugs. 2001;19(1):41-59. [PubMed:11291832]
  2. Tsukamoto Y, Kato Y, Ura M, Horii I, Ishitsuka H, Kusuhara H, Sugiyama Y: A physiologically based pharmacokinetic analysis of capecitabine, a triple prodrug of 5-FU, in humans: the mechanism for tumor-selective accumulation of 5-FU. Pharm Res. 2001 Aug;18(8):1190-202. [PubMed:11587492]
  3. Ishitsuka H, Shimma N, Horii I: [Discovery and development of novel anticancer drug capecitabine]. Yakugaku Zasshi. 1999 Dec;119(12):881-97. [PubMed:10630095]
  4. Ishitsuka H: Capecitabine: preclinical pharmacology studies. Invest New Drugs. 2000 Nov;18(4):343-54. [PubMed:11081570]
  5. Endo M, Miwa M, Eda H, Ura M, Tanimura H, Ishikawa T, Miyazaki-Nose T, Hattori K, Shimma N, Yamada-Okabe H, Ishitsuka H: Augmentation of the antitumor activity of capecitabine by a tumor selective dihydropyrimidine dehydrogenase inhibitor, RO0094889. Int J Cancer. 2003 Sep 20;106(5):799-805. [PubMed:12866042]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C9
Uniprot ID
P11712
Uniprot Name
Cytochrome P450 2C9
Molecular Weight
55627.365 Da
References
  1. Janney LM, Waterbury NV: Capecitabine-warfarin interaction. Ann Pharmacother. 2005 Sep;39(9):1546-51. doi: 10.1345/aph.1G153. Epub 2005 Jul 12. [PubMed:16014372]
  2. Xeloda (Capecitabine) FDA Label [Link]

Drug created on June 13, 2005 07:24 / Updated on September 18, 2018 23:02