| 16-Bromoepiandrosterone | The serum concentration of 16-Bromoepiandrosterone can be decreased when it is combined with Mitotane. | Investigational |
| 19-norandrostenedione | The serum concentration of 19-norandrostenedione can be decreased when it is combined with Mitotane. | Experimental, Illicit |
| 4-Androstenedione | The serum concentration of 4-Androstenedione can be decreased when it is combined with Mitotane. | Experimental, Illicit |
| 5-androstenedione | The serum concentration of 5-androstenedione can be decreased when it is combined with Mitotane. | Experimental, Illicit |
| Abiraterone | The serum concentration of Abiraterone can be decreased when it is combined with Mitotane. | Approved |
| Acenocoumarol | The serum concentration of Acenocoumarol can be decreased when it is combined with Mitotane. | Approved |
| Acetaminophen | The serum concentration of Acetaminophen can be decreased when it is combined with Mitotane. | Approved |
| Acetyldigitoxin | Acetyldigitoxin may decrease the cardiotoxic activities of Mitotane. | Approved |
| Adinazolam | The serum concentration of Adinazolam can be decreased when it is combined with Mitotane. | Approved |
| Albendazole | The serum concentration of Albendazole can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Alclometasone | The serum concentration of Alclometasone can be decreased when it is combined with Mitotane. | Approved |
| Aldosterone | The serum concentration of Aldosterone can be decreased when it is combined with Mitotane. | Experimental |
| Alfentanil | The serum concentration of Alfentanil can be decreased when it is combined with Mitotane. | Approved, Illicit |
| Alfuzosin | The serum concentration of Alfuzosin can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Aliskiren | The serum concentration of Aliskiren can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Allylestrenol | The serum concentration of Allylestrenol can be decreased when it is combined with Mitotane. | Approved |
| Almotriptan | The serum concentration of Almotriptan can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Alogliptin | The serum concentration of Alogliptin can be decreased when it is combined with Mitotane. | Approved |
| Alosetron | The serum concentration of Alosetron can be decreased when it is combined with Mitotane. | Approved, Withdrawn |
| Alprazolam | The serum concentration of Alprazolam can be decreased when it is combined with Mitotane. | Approved, Illicit, Investigational |
| Ambrisentan | The serum concentration of Ambrisentan can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Ambroxol | The serum concentration of Ambroxol can be decreased when it is combined with Mitotane. | Approved |
| Amcinonide | The serum concentration of Amcinonide can be decreased when it is combined with Mitotane. | Approved |
| Aminophenazone | The serum concentration of Aminophenazone can be decreased when it is combined with Mitotane. | Approved, Withdrawn |
| Aminophylline | The serum concentration of Aminophylline can be decreased when it is combined with Mitotane. | Approved |
| Amiodarone | The serum concentration of Amiodarone can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Amitriptyline | The serum concentration of Amitriptyline can be decreased when it is combined with Mitotane. | Approved |
| Amlodipine | The serum concentration of Amlodipine can be decreased when it is combined with Mitotane. | Approved |
| Amprenavir | The serum concentration of Amprenavir can be decreased when it is combined with Mitotane. | Approved |
| Antipyrine | The serum concentration of Antipyrine can be decreased when it is combined with Mitotane. | Approved |
| Apixaban | The serum concentration of Apixaban can be decreased when it is combined with Mitotane. | Approved |
| Apremilast | The serum concentration of Apremilast can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Aprepitant | The serum concentration of Aprepitant can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Argatroban | The serum concentration of Argatroban can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Aripiprazole | The serum concentration of Aripiprazole can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Artemether | The serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with Mitotane resulting in a loss in efficacy. | Approved |
| Asenapine | The serum concentration of Asenapine can be decreased when it is combined with Mitotane. | Approved |
| Astemizole | The serum concentration of Astemizole can be decreased when it is combined with Mitotane. | Approved, Withdrawn |
| Atazanavir | The serum concentration of Atazanavir can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Atorvastatin | The serum concentration of Atorvastatin can be decreased when it is combined with Mitotane. | Approved |
| Avanafil | The serum concentration of Avanafil can be decreased when it is combined with Mitotane. | Approved |
| Axitinib | The serum concentration of Axitinib can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Azelastine | The serum concentration of Azelastine can be decreased when it is combined with Mitotane. | Approved |
| Azithromycin | The serum concentration of Azithromycin can be decreased when it is combined with Mitotane. | Approved |
| Banoxantrone | The serum concentration of Banoxantrone can be decreased when it is combined with Mitotane. | Investigational |
| Beclomethasone dipropionate | The serum concentration of Beclomethasone dipropionate can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Bedaquiline | The serum concentration of Bedaquiline can be decreased when it is combined with Mitotane. | Approved |
| Benzphetamine | The serum concentration of Benzphetamine can be decreased when it is combined with Mitotane. | Approved, Illicit |
| Benzyl alcohol | The serum concentration of Benzyl alcohol can be decreased when it is combined with Mitotane. | Approved |
| Betamethasone | The serum concentration of Betamethasone can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Bevacizumab | Bevacizumab may increase the cardiotoxic activities of Mitotane. | Approved, Investigational |
| Bexarotene | The serum concentration of Bexarotene can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Bezafibrate | The serum concentration of Bezafibrate can be decreased when it is combined with Mitotane. | Approved |
| Bicalutamide | The serum concentration of Bicalutamide can be decreased when it is combined with Mitotane. | Approved |
| Bisoprolol | The serum concentration of Bisoprolol can be decreased when it is combined with Mitotane. | Approved |
| Boceprevir | The serum concentration of Boceprevir can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Bortezomib | The serum concentration of Bortezomib can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Bosentan | The serum concentration of Bosentan can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Bosutinib | The serum concentration of Bosutinib can be decreased when it is combined with Mitotane. | Approved |
| Brentuximab vedotin | The serum concentration of Brentuximab vedotin can be decreased when it is combined with Mitotane. | Approved |
| Brexpiprazole | The serum concentration of Brexpiprazole can be decreased when it is combined with Mitotane. | Approved |
| Brinzolamide | The serum concentration of Brinzolamide can be decreased when it is combined with Mitotane. | Approved |
| Bromazepam | The serum concentration of Bromazepam can be decreased when it is combined with Mitotane. | Approved, Illicit |
| Bromocriptine | The serum concentration of Bromocriptine can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Brompheniramine | The serum concentration of Brompheniramine can be decreased when it is combined with Mitotane. | Approved |
| Budesonide | The serum concentration of Budesonide can be decreased when it is combined with Mitotane. | Approved |
| Bupivacaine | The serum concentration of Bupivacaine can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Buprenorphine | The serum concentration of Buprenorphine can be decreased when it is combined with Mitotane. | Approved, Illicit, Investigational, Vet Approved |
| Bupropion | The serum concentration of Bupropion can be decreased when it is combined with Mitotane. | Approved |
| Buspirone | The serum concentration of Buspirone can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Busulfan | The serum concentration of Busulfan can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Cabazitaxel | The serum concentration of Cabazitaxel can be decreased when it is combined with Mitotane. | Approved |
| Cabergoline | The serum concentration of Cabergoline can be decreased when it is combined with Mitotane. | Approved |
| Cabozantinib | The serum concentration of Cabozantinib can be decreased when it is combined with Mitotane. | Approved |
| Caffeine | The serum concentration of Caffeine can be decreased when it is combined with Mitotane. | Approved |
| Calcitriol | The serum concentration of Calcitriol can be decreased when it is combined with Mitotane. | Approved, Nutraceutical |
| Canagliflozin | The serum concentration of Canagliflozin can be decreased when it is combined with Mitotane. | Approved |
| Cannabidiol | The serum concentration of Cannabidiol can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Carbamazepine | The serum concentration of Carbamazepine can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Carbinoxamine | The serum concentration of Carbinoxamine can be decreased when it is combined with Mitotane. | Approved |
| Cariprazine | The serum concentration of Cariprazine can be decreased when it is combined with Mitotane. | Approved |
| Carvedilol | The serum concentration of Carvedilol can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Celecoxib | The serum concentration of Celecoxib can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Celiprolol | The serum concentration of Celiprolol can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Cephalexin | The serum concentration of Cephalexin can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Ceritinib | The serum concentration of Ceritinib can be decreased when it is combined with Mitotane. | Approved |
| Cerivastatin | The serum concentration of Cerivastatin can be decreased when it is combined with Mitotane. | Withdrawn |
| Cevimeline | The serum concentration of Cevimeline can be decreased when it is combined with Mitotane. | Approved |
| Chenodeoxycholic acid | The serum concentration of Chenodeoxycholic acid can be decreased when it is combined with Mitotane. | Approved |
| Chlordiazepoxide | The serum concentration of Chlordiazepoxide can be decreased when it is combined with Mitotane. | Approved, Illicit |
| Chloroquine | The serum concentration of Chloroquine can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Chlorphenamine | The serum concentration of Chlorphenamine can be decreased when it is combined with Mitotane. | Approved |
| Chlorpromazine | The serum concentration of Chlorpromazine can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Chlorzoxazone | The serum concentration of Chlorzoxazone can be decreased when it is combined with Mitotane. | Approved |
| Cholecalciferol | The serum concentration of Cholecalciferol can be decreased when it is combined with Mitotane. | Approved, Nutraceutical |
| Ciclesonide | The serum concentration of Ciclesonide can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Cilostazol | The serum concentration of Cilostazol can be decreased when it is combined with Mitotane. | Approved |
| Cinacalcet | The serum concentration of Cinacalcet can be decreased when it is combined with Mitotane. | Approved |
| Cisapride | The serum concentration of Cisapride can be decreased when it is combined with Mitotane. | Approved, Investigational, Withdrawn |
| Citalopram | The serum concentration of Citalopram can be decreased when it is combined with Mitotane. | Approved |
| Clarithromycin | The serum concentration of Clarithromycin can be decreased when it is combined with Mitotane. | Approved |
| Clindamycin | The serum concentration of Clindamycin can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Clobazam | The serum concentration of Clobazam can be decreased when it is combined with Mitotane. | Approved, Illicit |
| Clobetasol propionate | The serum concentration of Clobetasol propionate can be decreased when it is combined with Mitotane. | Approved |
| Clocortolone | The serum concentration of Clocortolone can be decreased when it is combined with Mitotane. | Approved |
| Clofazimine | The serum concentration of Clofazimine can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Clofibrate | The serum concentration of Clofibrate can be decreased when it is combined with Mitotane. | Approved |
| Clomipramine | The serum concentration of Clomipramine can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Clonazepam | The serum concentration of Clonazepam can be decreased when it is combined with Mitotane. | Approved, Illicit |
| Clonidine | The serum concentration of Clonidine can be decreased when it is combined with Mitotane. | Approved |
| Clopidogrel | The serum concentration of Clopidogrel can be decreased when it is combined with Mitotane. | Approved, Nutraceutical |
| Clorazepate | The serum concentration of Clorazepate can be decreased when it is combined with Mitotane. | Approved, Illicit |
| Clotiazepam | The serum concentration of Clotiazepam can be decreased when it is combined with Mitotane. | Approved, Illicit |
| Clozapine | The serum concentration of Clozapine can be decreased when it is combined with Mitotane. | Approved |
| Cobimetinib | The serum concentration of Cobimetinib can be decreased when it is combined with Mitotane. | Approved |
| Cocaine | The serum concentration of Cocaine can be decreased when it is combined with Mitotane. | Approved, Illicit |
| Codeine | The serum concentration of Codeine can be decreased when it is combined with Mitotane. | Approved, Illicit |
| Colchicine | The serum concentration of Colchicine can be decreased when it is combined with Mitotane. | Approved |
| Conivaptan | The serum concentration of Conivaptan can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Conjugated Equine Estrogens | The serum concentration of Conjugated Equine Estrogens can be decreased when it is combined with Mitotane. | Approved |
| Cortisone acetate | The serum concentration of Cortisone acetate can be decreased when it is combined with Mitotane. | Approved |
| Crizotinib | The serum concentration of Crizotinib can be decreased when it is combined with Mitotane. | Approved |
| Cyclobenzaprine | The serum concentration of Cyclobenzaprine can be decreased when it is combined with Mitotane. | Approved |
| Cyclophosphamide | The serum concentration of Cyclophosphamide can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Cyclosporine | The serum concentration of Cyclosporine can be decreased when it is combined with Mitotane. | Approved, Investigational, Vet Approved |
| Cytarabine | The serum concentration of Cytarabine can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Dabrafenib | The serum concentration of Dabrafenib can be decreased when it is combined with Mitotane. | Approved |
| Daclatasvir | The serum concentration of Daclatasvir can be decreased when it is combined with Mitotane. | Approved |
| Dantrolene | The serum concentration of Dantrolene can be decreased when it is combined with Mitotane. | Approved |
| Dapagliflozin | The serum concentration of Dapagliflozin can be decreased when it is combined with Mitotane. | Approved |
| Dapsone | The serum concentration of Dapsone can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Darifenacin | The serum concentration of Darifenacin can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Darunavir | The serum concentration of Darunavir can be decreased when it is combined with Mitotane. | Approved |
| Dasabuvir | The serum concentration of Dasabuvir can be decreased when it is combined with Mitotane. | Approved |
| Dasatinib | The serum concentration of Dasatinib can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Daunorubicin | The serum concentration of Daunorubicin can be decreased when it is combined with Mitotane. | Approved |
| dehydroepiandrosterone sulfate | The serum concentration of dehydroepiandrosterone sulfate can be decreased when it is combined with Mitotane. | Investigational |
| Delavirdine | The serum concentration of Delavirdine can be decreased when it is combined with Mitotane. | Approved |
| Deslanoside | Deslanoside may decrease the cardiotoxic activities of Mitotane. | Approved |
| Desoximetasone | The serum concentration of Desoximetasone can be decreased when it is combined with Mitotane. | Approved |
| Desoxycorticosterone Pivalate | The serum concentration of Desoxycorticosterone Pivalate can be decreased when it is combined with Mitotane. | Experimental, Vet Approved |
| Desvenlafaxine | The serum concentration of Desvenlafaxine can be decreased when it is combined with Mitotane. | Approved |
| Dexamethasone | The serum concentration of Dexamethasone can be decreased when it is combined with Mitotane. | Approved, Investigational, Vet Approved |
| Dextromethorphan | The serum concentration of Dextromethorphan can be decreased when it is combined with Mitotane. | Approved |
| Dextropropoxyphene | The serum concentration of Dextropropoxyphene can be decreased when it is combined with Mitotane. | Approved, Illicit, Withdrawn |
| Diazepam | The serum concentration of Diazepam can be decreased when it is combined with Mitotane. | Approved, Illicit, Vet Approved |
| Diclofenac | The serum concentration of Diclofenac can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Dienogest | The serum concentration of Dienogest can be decreased when it is combined with Mitotane. | Approved |
| Diflorasone | The serum concentration of Diflorasone can be decreased when it is combined with Mitotane. | Approved |
| Difluocortolone | The serum concentration of Difluocortolone can be decreased when it is combined with Mitotane. | Approved |
| Difluprednate | The serum concentration of Difluprednate can be decreased when it is combined with Mitotane. | Approved |
| Digitoxin | The serum concentration of Digitoxin can be decreased when it is combined with Mitotane. | Approved |
| Digoxin | The serum concentration of Digoxin can be decreased when it is combined with Mitotane. | Approved |
| Dihydrocodeine | The serum concentration of Dihydrocodeine can be decreased when it is combined with Mitotane. | Approved, Illicit |
| Dihydroergotamine | The serum concentration of Dihydroergotamine can be decreased when it is combined with Mitotane. | Approved |
| Diltiazem | The serum concentration of Diltiazem can be decreased when it is combined with Mitotane. | Approved |
| Disopyramide | The serum concentration of Disopyramide can be decreased when it is combined with Mitotane. | Approved |
| Disulfiram | The serum concentration of Disulfiram can be decreased when it is combined with Mitotane. | Approved |
| Docetaxel | The serum concentration of Docetaxel can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Dofetilide | The serum concentration of Dofetilide can be decreased when it is combined with Mitotane. | Approved |
| Dolasetron | The serum concentration of Dolasetron can be decreased when it is combined with Mitotane. | Approved |
| Domperidone | The serum concentration of Domperidone can be decreased when it is combined with Mitotane. | Approved, Investigational, Vet Approved |
| Donepezil | The serum concentration of Donepezil can be decreased when it is combined with Mitotane. | Approved |
| Dorzolamide | The serum concentration of Dorzolamide can be decreased when it is combined with Mitotane. | Approved |
| Doxepin | The serum concentration of Doxepin can be decreased when it is combined with Mitotane. | Approved |
| Doxorubicin | The serum concentration of Doxorubicin can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Dronabinol | The serum concentration of Dronabinol can be decreased when it is combined with Mitotane. | Approved, Illicit |
| Dronedarone | The serum concentration of Dronedarone can be decreased when it is combined with Mitotane. | Approved |
| Dutasteride | The serum concentration of Dutasteride can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Efavirenz | The serum concentration of Efavirenz can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Eletriptan | The serum concentration of Eletriptan can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Eliglustat | The serum concentration of Eliglustat can be decreased when it is combined with Mitotane. | Approved |
| Elvitegravir | The serum concentration of Elvitegravir can be decreased when it is combined with Mitotane. | Approved |
| Enalapril | The serum concentration of Enalapril can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Enzalutamide | The serum concentration of Enzalutamide can be decreased when it is combined with Mitotane. | Approved |
| Epinastine | The serum concentration of Epinastine can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Eplerenone | The serum concentration of Eplerenone can be decreased when it is combined with Mitotane. | Approved |
| Equilenin | The serum concentration of Equilenin can be decreased when it is combined with Mitotane. | Experimental |
| Equilin | The serum concentration of Equilin can be decreased when it is combined with Mitotane. | Approved |
| Ergocalciferol | The serum concentration of Ergocalciferol can be decreased when it is combined with Mitotane. | Approved, Nutraceutical |
| Ergoloid mesylate | The serum concentration of Ergoloid mesylate can be decreased when it is combined with Mitotane. | Approved |
| Ergonovine | The serum concentration of Ergonovine can be decreased when it is combined with Mitotane. | Approved |
| Ergotamine | The serum concentration of Ergotamine can be decreased when it is combined with Mitotane. | Approved |
| Erlotinib | The serum concentration of Erlotinib can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Erythromycin | The serum concentration of Erythromycin can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Escitalopram | The serum concentration of Escitalopram can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Esomeprazole | The serum concentration of Esomeprazole can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Estazolam | The serum concentration of Estazolam can be decreased when it is combined with Mitotane. | Approved, Illicit |
| Estradiol | The serum concentration of Estradiol can be decreased when it is combined with Mitotane. | Approved, Investigational, Vet Approved |
| Estramustine | The serum concentration of Estramustine can be decreased when it is combined with Mitotane. | Approved |
| Estrone | The serum concentration of Estrone can be decreased when it is combined with Mitotane. | Approved |
| Estrone sulfate | The serum concentration of Estrone sulfate can be decreased when it is combined with Mitotane. | Approved |
| Eszopiclone | The serum concentration of Eszopiclone can be decreased when it is combined with Mitotane. | Approved |
| Ethanol | The serum concentration of Ethanol can be decreased when it is combined with Mitotane. | Approved |
| Ethinyl Estradiol | The serum concentration of Ethinyl Estradiol can be decreased when it is combined with Mitotane. | Approved |
| Ethosuximide | The serum concentration of Ethosuximide can be decreased when it is combined with Mitotane. | Approved |
| Ethylmorphine | The serum concentration of Ethylmorphine can be decreased when it is combined with Mitotane. | Approved, Illicit |
| Etonogestrel | The serum concentration of Etonogestrel can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Etoposide | The serum concentration of Etoposide can be decreased when it is combined with Mitotane. | Approved |
| Etoricoxib | The serum concentration of Etoricoxib can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Etravirine | The serum concentration of Etravirine can be decreased when it is combined with Mitotane. | Approved |
| Everolimus | The serum concentration of Everolimus can be decreased when it is combined with Mitotane. | Approved |
| Exemestane | The serum concentration of Exemestane can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Famciclovir | The serum concentration of Famciclovir can be decreased when it is combined with Mitotane. | Approved |
| Felbamate | The serum concentration of Felbamate can be decreased when it is combined with Mitotane. | Approved |
| Felodipine | The serum concentration of Felodipine can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Fenofibrate | The serum concentration of Fenofibrate can be decreased when it is combined with Mitotane. | Approved |
| Fentanyl | The serum concentration of Fentanyl can be decreased when it is combined with Mitotane. | Approved, Illicit, Investigational, Vet Approved |
| Fesoterodine | The serum concentration of Fesoterodine can be decreased when it is combined with Mitotane. | Approved |
| Finasteride | The serum concentration of Finasteride can be decreased when it is combined with Mitotane. | Approved |
| Fingolimod | The serum concentration of Fingolimod can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Flibanserin | The serum concentration of Flibanserin can be decreased when it is combined with Mitotane. | Approved |
| Fludrocortisone | The serum concentration of Fludrocortisone can be decreased when it is combined with Mitotane. | Approved |
| Flumethasone | The serum concentration of Flumethasone can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Flunisolide | The serum concentration of Flunisolide can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Flunitrazepam | The serum concentration of Flunitrazepam can be decreased when it is combined with Mitotane. | Approved, Illicit |
| Fluocinolone Acetonide | The serum concentration of Fluocinolone Acetonide can be decreased when it is combined with Mitotane. | Approved, Investigational, Vet Approved |
| Fluocinonide | The serum concentration of Fluocinonide can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Fluocortolone | The serum concentration of Fluocortolone can be decreased when it is combined with Mitotane. | Approved, Withdrawn |
| Fluorometholone | The serum concentration of Fluorometholone can be decreased when it is combined with Mitotane. | Approved |
| Fluoxetine | The serum concentration of Fluoxetine can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Fluprednidene | The serum concentration of Fluprednidene can be decreased when it is combined with Mitotane. | Approved, Withdrawn |
| Flurandrenolide | The serum concentration of Flurandrenolide can be decreased when it is combined with Mitotane. | Approved |
| Flurazepam | The serum concentration of Flurazepam can be decreased when it is combined with Mitotane. | Approved, Illicit |
| Flutamide | The serum concentration of Flutamide can be decreased when it is combined with Mitotane. | Approved |
| Fluticasone furoate | The serum concentration of Fluticasone furoate can be decreased when it is combined with Mitotane. | Approved |
| Fluticasone Propionate | The serum concentration of Fluticasone Propionate can be decreased when it is combined with Mitotane. | Approved |
| Fluvastatin | The serum concentration of Fluvastatin can be decreased when it is combined with Mitotane. | Approved |
| Formestane | The serum concentration of Formestane can be decreased when it is combined with Mitotane. | Approved, Investigational, Withdrawn |
| Fosamprenavir | The serum concentration of Fosamprenavir can be decreased when it is combined with Mitotane. | Approved |
| Fulvestrant | The serum concentration of Fulvestrant can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Galantamine | The serum concentration of Galantamine can be decreased when it is combined with Mitotane. | Approved |
| Gefitinib | The serum concentration of Gefitinib can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Gemfibrozil | The serum concentration of Gemfibrozil can be decreased when it is combined with Mitotane. | Approved |
| Glipizide | The serum concentration of Glipizide can be decreased when it is combined with Mitotane. | Approved |
| Glyburide | The serum concentration of Glyburide can be decreased when it is combined with Mitotane. | Approved |
| Granisetron | The serum concentration of Granisetron can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Grepafloxacin | The serum concentration of Grepafloxacin can be decreased when it is combined with Mitotane. | Withdrawn |
| Guanfacine | The serum concentration of Guanfacine can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Halofantrine | The serum concentration of Halofantrine can be decreased when it is combined with Mitotane. | Approved |
| Haloperidol | The serum concentration of Haloperidol can be decreased when it is combined with Mitotane. | Approved |
| Halothane | The serum concentration of Halothane can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| HE3286 | The serum concentration of HE3286 can be decreased when it is combined with Mitotane. | Investigational |
| Hexobarbital | The serum concentration of Hexobarbital can be decreased when it is combined with Mitotane. | Approved |
| Histamine | The serum concentration of Histamine Phosphate can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Hydrocodone | The serum concentration of Hydrocodone can be decreased when it is combined with Mitotane. | Approved, Illicit |
| Hydrocortisone | The serum concentration of Hydrocortisone can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Hydromorphone | The serum concentration of Hydromorphone can be decreased when it is combined with Mitotane. | Approved, Illicit |
| Hydroxyprogesterone caproate | The serum concentration of Hydroxyprogesterone caproate can be decreased when it is combined with Mitotane. | Approved |
| Ibrutinib | The serum concentration of Ibrutinib can be decreased when it is combined with Mitotane. | Approved |
| Idelalisib | The serum concentration of Idelalisib can be decreased when it is combined with Mitotane. | Approved |
| Ifosfamide | The serum concentration of Ifosfamide can be decreased when it is combined with Mitotane. | Approved |
| Iloperidone | The serum concentration of Iloperidone can be decreased when it is combined with Mitotane. | Approved |
| Imatinib | The serum concentration of Imatinib can be decreased when it is combined with Mitotane. | Approved |
| Imipramine | The serum concentration of Imipramine can be decreased when it is combined with Mitotane. | Approved |
| Imiquimod | The serum concentration of Imiquimod can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Indacaterol | The serum concentration of Indacaterol can be decreased when it is combined with Mitotane. | Approved |
| Indapamide | The serum concentration of Indapamide can be decreased when it is combined with Mitotane. | Approved |
| Indinavir | The serum concentration of Indinavir can be decreased when it is combined with Mitotane. | Approved |
| Ipratropium bromide | The serum concentration of Ipratropium bromide can be decreased when it is combined with Mitotane. | Approved |
| Irinotecan | The serum concentration of the active metabolites of Irinotecan can be reduced when Irinotecan is used in combination with Mitotane resulting in a loss in efficacy. | Approved, Investigational |
| Isavuconazonium | The serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Mitotane resulting in a loss in efficacy. | Approved, Investigational |
| Isosorbide Dinitrate | The serum concentration of Isosorbide Dinitrate can be decreased when it is combined with Mitotane. | Approved |
| Isosorbide Mononitrate | The serum concentration of Isosorbide Mononitrate can be decreased when it is combined with Mitotane. | Approved |
| Isradipine | The serum concentration of Isradipine can be decreased when it is combined with Mitotane. | Approved |
| Itraconazole | The serum concentration of Itraconazole can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Ivabradine | The serum concentration of Ivabradine can be decreased when it is combined with Mitotane. | Approved |
| Ivacaftor | The serum concentration of Ivacaftor can be decreased when it is combined with Mitotane. | Approved |
| Ivermectin | The serum concentration of Ivermectin can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Ixabepilone | The serum concentration of Ixabepilone can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Ixazomib | The serum concentration of Ixazomib can be decreased when it is combined with Mitotane. | Approved |
| Ketamine | The serum concentration of Ketamine can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Ketazolam | The serum concentration of Ketazolam can be decreased when it is combined with Mitotane. | Approved |
| Ketobemidone | The serum concentration of Ketobemidone can be decreased when it is combined with Mitotane. | Approved |
| Ketoconazole | The serum concentration of Ketoconazole can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Lansoprazole | The serum concentration of Lansoprazole can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Lapatinib | The serum concentration of Lapatinib can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Laquinimod | The serum concentration of Laquinimod can be decreased when it is combined with Mitotane. | Investigational |
| Lenvatinib | The serum concentration of Lenvatinib can be decreased when it is combined with Mitotane. | Approved |
| Lercanidipine | The serum concentration of Lercanidipine can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Letrozole | The serum concentration of Letrozole can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Levobupivacaine | The serum concentration of Levobupivacaine can be decreased when it is combined with Mitotane. | Approved |
| Levocetirizine | The serum concentration of Levocetirizine can be decreased when it is combined with Mitotane. | Approved |
| Levomethadyl Acetate | The serum concentration of Levomethadyl Acetate can be decreased when it is combined with Mitotane. | Approved |
| Levomilnacipran | The serum concentration of Levomilnacipran can be decreased when it is combined with Mitotane. | Approved |
| Levonorgestrel | The serum concentration of Levonorgestrel can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Levothyroxine | The serum concentration of Levothyroxine can be decreased when it is combined with Mitotane. | Approved |
| Lidocaine | The serum concentration of Lidocaine can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Linagliptin | The serum concentration of Linagliptin can be decreased when it is combined with Mitotane. | Approved |
| Lisuride | The serum concentration of Lisuride can be decreased when it is combined with Mitotane. | Approved |
| Lomitapide | The serum concentration of Lomitapide can be decreased when it is combined with Mitotane. | Approved |
| Loperamide | The serum concentration of Loperamide can be decreased when it is combined with Mitotane. | Approved |
| Lopinavir | The serum concentration of Lopinavir can be decreased when it is combined with Mitotane. | Approved |
| Loratadine | The serum concentration of Loratadine can be decreased when it is combined with Mitotane. | Approved |
| Lorcaserin | The serum concentration of Lorcaserin can be decreased when it is combined with Mitotane. | Approved |
| Losartan | The serum concentration of Losartan can be decreased when it is combined with Mitotane. | Approved |
| Lovastatin | The serum concentration of Lovastatin can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Lumefantrine | The serum concentration of Lumefantrine can be decreased when it is combined with Mitotane. | Approved |
| Lurasidone | The serum concentration of Lurasidone can be decreased when it is combined with Mitotane. | Approved |
| Macitentan | The serum concentration of Macitentan can be decreased when it is combined with Mitotane. | Approved |
| Maraviroc | The serum concentration of Maraviroc can be decreased when it is combined with Mitotane. | Approved, Investigational |
| ME-609 | The serum concentration of ME-609 can be decreased when it is combined with Mitotane. | Investigational |
| Mebendazole | The serum concentration of Mebendazole can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Medroxyprogesterone acetate | The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Medrysone | The serum concentration of Medrysone can be decreased when it is combined with Mitotane. | Approved |
| Mefloquine | The serum concentration of Mefloquine can be decreased when it is combined with Mitotane. | Approved |
| Meloxicam | The serum concentration of Meloxicam can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Methadone | The serum concentration of Methadone can be decreased when it is combined with Mitotane. | Approved |
| Methaqualone | The serum concentration of Methaqualone can be decreased when it is combined with Mitotane. | Illicit, Withdrawn |
| Methoxsalen | The serum concentration of Methoxsalen can be decreased when it is combined with Mitotane. | Approved |
| Methoxyflurane | The serum concentration of Methoxyflurane can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Methylprednisolone | The serum concentration of Methylprednisolone can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Methyltestosterone | The serum concentration of Methyltestosterone can be decreased when it is combined with Mitotane. | Approved |
| Metronidazole | The serum concentration of Metronidazole can be decreased when it is combined with Mitotane. | Approved |
| Mexiletine | The serum concentration of Mexiletine can be decreased when it is combined with Mitotane. | Approved |
| Mianserin | The serum concentration of Mianserin can be decreased when it is combined with Mitotane. | Approved |
| Mibefradil | The serum concentration of Mibefradil can be decreased when it is combined with Mitotane. | Withdrawn |
| Miconazole | The serum concentration of Miconazole can be decreased when it is combined with Mitotane. | Approved, Investigational, Vet Approved |
| Midazolam | The serum concentration of Midazolam can be decreased when it is combined with Mitotane. | Approved, Illicit |
| Mifepristone | The serum concentration of Mifepristone can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Mirabegron | The serum concentration of Mirabegron can be decreased when it is combined with Mitotane. | Approved |
| Mirtazapine | The serum concentration of Mirtazapine can be decreased when it is combined with Mitotane. | Approved |
| Modafinil | The serum concentration of Modafinil can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Mometasone | The serum concentration of Mometasone can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Montelukast | The serum concentration of Montelukast can be decreased when it is combined with Mitotane. | Approved |
| Morphine | The serum concentration of Morphine can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Mycophenolate mofetil | The serum concentration of Mycophenolate mofetil can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Naloxegol | The serum concentration of Naloxegol can be decreased when it is combined with Mitotane. | Approved |
| Naloxone | The serum concentration of Naloxone can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Nateglinide | The serum concentration of Nateglinide can be decreased when it is combined with Mitotane. | Approved, Investigational |
| NCX 1022 | The serum concentration of NCX 1022 can be decreased when it is combined with Mitotane. | Investigational |
| Nefazodone | The serum concentration of Nefazodone can be decreased when it is combined with Mitotane. | Approved, Withdrawn |
| Nelfinavir | The serum concentration of Nelfinavir can be decreased when it is combined with Mitotane. | Approved |
| Netupitant | The serum concentration of Netupitant can be decreased when it is combined with Mitotane. | Approved |
| Nevirapine | The serum concentration of Nevirapine can be decreased when it is combined with Mitotane. | Approved |
| Nicardipine | The serum concentration of Nicardipine can be decreased when it is combined with Mitotane. | Approved |
| Nicotine | The serum concentration of Nicotine can be decreased when it is combined with Mitotane. | Approved |
| Nifedipine | The serum concentration of Nifedipine can be decreased when it is combined with Mitotane. | Approved |
| Nilotinib | The serum concentration of Nilotinib can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Nilvadipine | The serum concentration of Nilvadipine can be decreased when it is combined with Mitotane. | Approved |
| Nimodipine | The serum concentration of Nimodipine can be decreased when it is combined with Mitotane. | Approved |
| Nisoldipine | The serum concentration of Nisoldipine can be decreased when it is combined with Mitotane. | Approved |
| Nitrazepam | The serum concentration of Nitrazepam can be decreased when it is combined with Mitotane. | Approved |
| Nitrendipine | The serum concentration of Nitrendipine can be decreased when it is combined with Mitotane. | Approved |
| Norethisterone | The serum concentration of Norethisterone can be decreased when it is combined with Mitotane. | Approved |
| Norgestrel | The serum concentration of Norgestrel can be decreased when it is combined with Mitotane. | Approved |
| Nortriptyline | The serum concentration of Nortriptyline can be decreased when it is combined with Mitotane. | Approved |
| Olaparib | The serum concentration of Olaparib can be decreased when it is combined with Mitotane. | Approved |
| Oleandrin | Anvirzel may decrease the cardiotoxic activities of Mitotane. | Experimental |
| Oleoyl estrone | The serum concentration of Oleoyl estrone can be decreased when it is combined with Mitotane. | Investigational |
| Olopatadine | The serum concentration of Olopatadine can be decreased when it is combined with Mitotane. | Approved |
| Omeprazole | The serum concentration of Omeprazole can be decreased when it is combined with Mitotane. | Approved, Investigational, Vet Approved |
| Ondansetron | The serum concentration of Ondansetron can be decreased when it is combined with Mitotane. | Approved |
| Orphenadrine | The serum concentration of Orphenadrine can be decreased when it is combined with Mitotane. | Approved |
| Osimertinib | The serum concentration of Osimertinib can be decreased when it is combined with Mitotane. | Approved |
| Ospemifene | The serum concentration of Ospemifene can be decreased when it is combined with Mitotane. | Approved |
| Ouabain | Ouabain may decrease the cardiotoxic activities of Mitotane. | Approved |
| Oxazepam | The serum concentration of Oxazepam can be decreased when it is combined with Mitotane. | Approved |
| Oxybutynin | The serum concentration of Oxybutynin can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Oxycodone | The serum concentration of Oxycodone can be decreased when it is combined with Mitotane. | Approved, Illicit, Investigational |
| Oxymorphone | The serum concentration of Oxymorphone can be decreased when it is combined with Mitotane. | Approved, Investigational, Vet Approved |
| Paclitaxel | The serum concentration of Paclitaxel can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Palbociclib | The serum concentration of Palbociclib can be decreased when it is combined with Mitotane. | Approved |
| Palonosetron | The serum concentration of Palonosetron can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Panobinostat | The serum concentration of Panobinostat can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Pantoprazole | The serum concentration of Pantoprazole can be decreased when it is combined with Mitotane. | Approved |
| Paramethadione | The serum concentration of Paramethadione can be decreased when it is combined with Mitotane. | Approved |
| Paramethasone | The serum concentration of Paramethasone can be decreased when it is combined with Mitotane. | Approved |
| Parecoxib | The serum concentration of Parecoxib can be decreased when it is combined with Mitotane. | Approved |
| Paricalcitol | The serum concentration of Paricalcitol can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Paritaprevir | The serum concentration of Paritaprevir can be decreased when it is combined with Mitotane. | Approved |
| Pazopanib | The serum concentration of Pazopanib can be decreased when it is combined with Mitotane. | Approved |
| Pentamidine | The serum concentration of Pentamidine can be decreased when it is combined with Mitotane. | Approved |
| Perampanel | The serum concentration of Perampanel can be decreased when it is combined with Mitotane. | Approved |
| Pergolide | The serum concentration of Pergolide can be decreased when it is combined with Mitotane. | Approved, Vet Approved, Withdrawn |
| Perhexiline | The serum concentration of Perhexiline can be decreased when it is combined with Mitotane. | Approved |
| Permethrin | The serum concentration of Permethrin can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Perphenazine | The serum concentration of Perphenazine can be decreased when it is combined with Mitotane. | Approved |
| Pethidine | The serum concentration of Pethidine can be decreased when it is combined with Mitotane. | Approved |
| Phenacetin | The serum concentration of Phenacetin can be decreased when it is combined with Mitotane. | Withdrawn |
| Phenoxybenzamine | The serum concentration of Phenoxybenzamine can be decreased when it is combined with Mitotane. | Approved |
| Phenprocoumon | The serum concentration of Phenprocoumon can be decreased when it is combined with Mitotane. | Approved |
| Phenytoin | The serum concentration of Phenytoin can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Pilocarpine | The serum concentration of Pilocarpine can be decreased when it is combined with Mitotane. | Approved |
| Pimecrolimus | The serum concentration of Pimecrolimus can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Pimozide | The serum concentration of Pimozide can be decreased when it is combined with Mitotane. | Approved |
| Pioglitazone | The serum concentration of Pioglitazone can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Pipotiazine | The serum concentration of Pipotiazine can be decreased when it is combined with Mitotane. | Approved |
| Podofilox | The serum concentration of Podofilox can be decreased when it is combined with Mitotane. | Approved |
| Pomalidomide | The serum concentration of Pomalidomide can be decreased when it is combined with Mitotane. | Approved |
| Ponatinib | The serum concentration of Ponatinib can be decreased when it is combined with Mitotane. | Approved |
| Posaconazole | The serum concentration of Posaconazole can be decreased when it is combined with Mitotane. | Approved, Investigational, Vet Approved |
| Prasterone | The serum concentration of Prasterone can be decreased when it is combined with Mitotane. | Approved, Nutraceutical |
| Prasugrel | The serum concentration of Prasugrel can be decreased when it is combined with Mitotane. | Approved |
| Pravastatin | The serum concentration of Pravastatin can be decreased when it is combined with Mitotane. | Approved |
| Prazepam | The serum concentration of Prazepam can be decreased when it is combined with Mitotane. | Approved, Illicit |
| Praziquantel | The serum concentration of Praziquantel can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Prednicarbate | The serum concentration of Prednicarbate can be decreased when it is combined with Mitotane. | Approved |
| Prednisolone | The serum concentration of Prednisolone can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Prednisone | The serum concentration of Prednisone can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Pregnenolone | The serum concentration of Pregnenolone can be decreased when it is combined with Mitotane. | Experimental |
| Primaquine | The serum concentration of Primaquine can be decreased when it is combined with Mitotane. | Approved |
| Prochlorperazine | The serum concentration of Prochlorperazine can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Progesterone | The serum concentration of Progesterone can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Proguanil | The serum concentration of Proguanil can be decreased when it is combined with Mitotane. | Approved |
| Promazine | The serum concentration of Promazine can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Propafenone | The serum concentration of Propafenone can be decreased when it is combined with Mitotane. | Approved |
| Propofol | The serum concentration of Propofol can be decreased when it is combined with Mitotane. | Approved, Investigational, Vet Approved |
| Propranolol | The serum concentration of Propranolol can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Pyrazinamide | The serum concentration of Pyrazinamide can be decreased when it is combined with Mitotane. | Approved |
| Quazepam | The serum concentration of Quazepam can be decreased when it is combined with Mitotane. | Approved, Illicit |
| Quetiapine | The serum concentration of Quetiapine can be decreased when it is combined with Mitotane. | Approved |
| Quinacrine | The serum concentration of Quinacrine can be decreased when it is combined with Mitotane. | Approved |
| Quinidine | The serum concentration of Quinidine can be decreased when it is combined with Mitotane. | Approved |
| Quinine | The serum concentration of Quinine can be decreased when it is combined with Mitotane. | Approved |
| Rabeprazole | The serum concentration of Rabeprazole can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Raloxifene | The serum concentration of Raloxifene can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Ramelteon | The serum concentration of Ramelteon can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Ranolazine | The serum concentration of Ranolazine can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Reboxetine | The serum concentration of Reboxetine can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Regorafenib | The serum concentration of Regorafenib can be decreased when it is combined with Mitotane. | Approved |
| Repaglinide | The serum concentration of Repaglinide can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Retapamulin | The serum concentration of Retapamulin can be decreased when it is combined with Mitotane. | Approved |
| Rifabutin | The serum concentration of Rifabutin can be decreased when it is combined with Mitotane. | Approved |
| Rifampicin | The serum concentration of Rifampicin can be decreased when it is combined with Mitotane. | Approved |
| Rilpivirine | The serum concentration of Rilpivirine can be decreased when it is combined with Mitotane. | Approved |
| Rimexolone | The serum concentration of Rimexolone can be decreased when it is combined with Mitotane. | Approved |
| Rimonabant | The serum concentration of Rimonabant can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Riociguat | The serum concentration of Riociguat can be decreased when it is combined with Mitotane. | Approved |
| Risperidone | The serum concentration of Risperidone can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Ritonavir | The serum concentration of Ritonavir can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Rivaroxaban | The serum concentration of Rivaroxaban can be decreased when it is combined with Mitotane. | Approved |
| Rofecoxib | The serum concentration of Rofecoxib can be decreased when it is combined with Mitotane. | Investigational, Withdrawn |
| Roflumilast | The serum concentration of Roflumilast can be decreased when it is combined with Mitotane. | Approved |
| Rolapitant | The serum concentration of Rolapitant can be decreased when it is combined with Mitotane. | Approved |
| Romidepsin | The serum concentration of Romidepsin can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Ropinirole | The serum concentration of Ropinirole can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Ropivacaine | The serum concentration of Ropivacaine can be decreased when it is combined with Mitotane. | Approved |
| Rosuvastatin | The serum concentration of Rosuvastatin can be decreased when it is combined with Mitotane. | Approved |
| Rotigotine | The serum concentration of Rotigotine can be decreased when it is combined with Mitotane. | Approved |
| Roxithromycin | The serum concentration of Roxithromycin can be decreased when it is combined with Mitotane. | Approved, Withdrawn |
| Ruxolitinib | The serum concentration of Ruxolitinib can be decreased when it is combined with Mitotane. | Approved |
| Salmeterol | The serum concentration of Salmeterol can be decreased when it is combined with Mitotane. | Approved |
| Saquinavir | The serum concentration of Saquinavir can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Saxagliptin | The serum concentration of Saxagliptin can be decreased when it is combined with Mitotane. | Approved |
| Selegiline | The serum concentration of Selegiline can be decreased when it is combined with Mitotane. | Approved, Investigational, Vet Approved |
| Selexipag | The serum concentration of Selexipag can be decreased when it is combined with Mitotane. | Approved |
| Sertindole | The serum concentration of Sertindole can be decreased when it is combined with Mitotane. | Approved, Withdrawn |
| Sertraline | The serum concentration of Sertraline can be decreased when it is combined with Mitotane. | Approved |
| Sevoflurane | The serum concentration of Sevoflurane can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Sibutramine | The serum concentration of Sibutramine can be decreased when it is combined with Mitotane. | Approved, Illicit, Investigational, Withdrawn |
| Sildenafil | The serum concentration of Sildenafil can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Silodosin | The serum concentration of Silodosin can be decreased when it is combined with Mitotane. | Approved |
| Simeprevir | The serum concentration of Simeprevir can be decreased when it is combined with Mitotane. | Approved |
| Simvastatin | The serum concentration of Simvastatin can be decreased when it is combined with Mitotane. | Approved |
| Sirolimus | The serum concentration of Sirolimus can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Sitagliptin | The serum concentration of Sitagliptin can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Solifenacin | The serum concentration of Solifenacin can be decreased when it is combined with Mitotane. | Approved |
| Sonidegib | The serum concentration of Sonidegib can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Sorafenib | The serum concentration of Sorafenib can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Spiramycin | The serum concentration of Spiramycin can be decreased when it is combined with Mitotane. | Approved |
| Spironolactone | The therapeutic efficacy of Mitotane can be decreased when used in combination with Spironolactone. | Approved |
| Sufentanil | The serum concentration of Sufentanil can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Sulfadiazine | The serum concentration of Sulfadiazine can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Sulfamethoxazole | The serum concentration of Sulfamethoxazole can be decreased when it is combined with Mitotane. | Approved |
| Sulfinpyrazone | The serum concentration of Sulfinpyrazone can be decreased when it is combined with Mitotane. | Approved |
| Sunitinib | The serum concentration of Sunitinib can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Suvorexant | The serum concentration of Suvorexant can be decreased when it is combined with Mitotane. | Approved |
| Synthetic Conjugated Estrogens, A | The serum concentration of Synthetic Conjugated Estrogens, A can be decreased when it is combined with Mitotane. | Approved |
| Synthetic Conjugated Estrogens, B | The serum concentration of Synthetic Conjugated Estrogens, B can be decreased when it is combined with Mitotane. | Approved |
| Tacrolimus | The serum concentration of Tacrolimus can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Tadalafil | The serum concentration of Tadalafil can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Tamoxifen | The serum concentration of Tamoxifen can be decreased when it is combined with Mitotane. | Approved |
| Tamsulosin | The serum concentration of Tamsulosin can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Tasimelteon | The serum concentration of Tasimelteon can be decreased when it is combined with Mitotane. | Approved |
| Tasosartan | The serum concentration of Tasosartan can be decreased when it is combined with Mitotane. | Approved |
| Telaprevir | The serum concentration of Telaprevir can be decreased when it is combined with Mitotane. | Approved |
| Telithromycin | The serum concentration of Telithromycin can be decreased when it is combined with Mitotane. | Approved |
| Temazepam | The serum concentration of Temazepam can be decreased when it is combined with Mitotane. | Approved |
| Temsirolimus | The serum concentration of Temsirolimus can be decreased when it is combined with Mitotane. | Approved |
| Teniposide | The serum concentration of Teniposide can be decreased when it is combined with Mitotane. | Approved |
| Terbinafine | The serum concentration of Terbinafine can be decreased when it is combined with Mitotane. | Approved, Investigational, Vet Approved |
| Terfenadine | The serum concentration of Terfenadine can be decreased when it is combined with Mitotane. | Withdrawn |
| Tesmilifene | The serum concentration of Tesmilifene can be decreased when it is combined with Mitotane. | Investigational |
| Testosterone | The serum concentration of Testosterone can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Tetracycline | The serum concentration of Tetracycline can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Theophylline | The serum concentration of Theophylline can be decreased when it is combined with Mitotane. | Approved |
| Thiotepa | The serum concentration of Thiotepa can be decreased when it is combined with Mitotane. | Approved |
| Tiagabine | The serum concentration of Tiagabine can be decreased when it is combined with Mitotane. | Approved |
| Ticagrelor | The serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Mitotane resulting in a loss in efficacy. | Approved |
| Ticlopidine | The serum concentration of Ticlopidine can be decreased when it is combined with Mitotane. | Approved |
| Tinidazole | The serum concentration of Tinidazole can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Tiotropium | The serum concentration of Tiotropium can be decreased when it is combined with Mitotane. | Approved |
| Tipranavir | The serum concentration of Tipranavir can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Tixocortol | The serum concentration of Tixocortol can be decreased when it is combined with Mitotane. | Approved |
| Tofacitinib | The serum concentration of Tofacitinib can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Tolterodine | The serum concentration of Tolterodine can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Tolvaptan | The serum concentration of Tolvaptan can be decreased when it is combined with Mitotane. | Approved |
| Toremifene | The serum concentration of Toremifene can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Trabectedin | The serum concentration of Trabectedin can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Tramadol | The serum concentration of Tramadol can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Trastuzumab | Trastuzumab may increase the cardiotoxic activities of Mitotane. | Approved, Investigational |
| Trastuzumab emtansine | The serum concentration of Trastuzumab emtansine can be decreased when it is combined with Mitotane. | Approved |
| Trazodone | The serum concentration of Trazodone can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Tretinoin | The serum concentration of Tretinoin can be decreased when it is combined with Mitotane. | Approved, Investigational, Nutraceutical |
| Triamcinolone | The serum concentration of Triamcinolone can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Triazolam | The serum concentration of Triazolam can be decreased when it is combined with Mitotane. | Approved |
| Trimethadione | The serum concentration of Trimethadione can be decreased when it is combined with Mitotane. | Approved |
| Trimethoprim | The serum concentration of Trimethoprim can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Trimipramine | The serum concentration of Trimipramine can be decreased when it is combined with Mitotane. | Approved |
| Troglitazone | The serum concentration of Troglitazone can be decreased when it is combined with Mitotane. | Withdrawn |
| Troleandomycin | The serum concentration of Troleandomycin can be decreased when it is combined with Mitotane. | Approved |
| Udenafil | The serum concentration of Udenafil can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Ulipristal | The serum concentration of Ulipristal can be decreased when it is combined with Mitotane. | Approved |
| Valdecoxib | The serum concentration of Valdecoxib can be decreased when it is combined with Mitotane. | Investigational, Withdrawn |
| Vandetanib | The serum concentration of Vandetanib can be decreased when it is combined with Mitotane. | Approved |
| Vanoxerine | The serum concentration of Vanoxerine can be decreased when it is combined with Mitotane. | Investigational |
| Vardenafil | The serum concentration of Vardenafil can be decreased when it is combined with Mitotane. | Approved |
| Vemurafenib | The serum concentration of Vemurafenib can be decreased when it is combined with Mitotane. | Approved |
| Venetoclax | The serum concentration of Venetoclax can be decreased when it is combined with Mitotane. | Approved |
| Venlafaxine | The serum concentration of Venlafaxine can be decreased when it is combined with Mitotane. | Approved |
| Verapamil | The serum concentration of Verapamil can be decreased when it is combined with Mitotane. | Approved |
| Vilanterol | The serum concentration of Vilanterol can be decreased when it is combined with Mitotane. | Approved |
| Vilazodone | The serum concentration of Vilazodone can be decreased when it is combined with Mitotane. | Approved |
| Vinblastine | The serum concentration of Vinblastine can be decreased when it is combined with Mitotane. | Approved |
| Vincristine | The serum concentration of Vincristine can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Vindesine | The serum concentration of Vindesine can be decreased when it is combined with Mitotane. | Approved |
| Vinorelbine | The serum concentration of Vinorelbine can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Vismodegib | The serum concentration of Vismodegib can be decreased when it is combined with Mitotane. | Approved |
| Vorapaxar | The serum concentration of Vorapaxar can be decreased when it is combined with Mitotane. | Approved |
| Voriconazole | The serum concentration of Voriconazole can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Vortioxetine | The serum concentration of Vortioxetine can be decreased when it is combined with Mitotane. | Approved |
| Warfarin | The serum concentration of Warfarin can be decreased when it is combined with Mitotane. | Approved |
| Yohimbine | The serum concentration of Yohimbine can be decreased when it is combined with Mitotane. | Approved, Vet Approved |
| Zafirlukast | The serum concentration of Zafirlukast can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Zalcitabine | The serum concentration of Zalcitabine can be decreased when it is combined with Mitotane. | Approved |
| Zaleplon | The serum concentration of Zaleplon can be decreased when it is combined with Mitotane. | Approved, Illicit, Investigational |
| Zidovudine | The serum concentration of Zidovudine can be decreased when it is combined with Mitotane. | Approved |
| Zileuton | The serum concentration of Zileuton can be decreased when it is combined with Mitotane. | Approved, Investigational, Withdrawn |
| Ziprasidone | The serum concentration of Ziprasidone can be decreased when it is combined with Mitotane. | Approved |
| Zolpidem | The serum concentration of Zolpidem can be decreased when it is combined with Mitotane. | Approved |
| Zomepirac | The serum concentration of Zomepirac can be decreased when it is combined with Mitotane. | Withdrawn |
| Zonisamide | The serum concentration of Zonisamide can be decreased when it is combined with Mitotane. | Approved, Investigational |
| Zopiclone | The serum concentration of Zopiclone can be decreased when it is combined with Mitotane. | Approved |
| Zuclopenthixol | The serum concentration of Zuclopenthixol can be decreased when it is combined with Mitotane. | Approved, Investigational |
