Identification

Name
Mitotane
Accession Number
DB00648  (APRD00494)
Type
Small Molecule
Groups
Approved
Description

A derivative of the insecticide dichlorodiphenyldichloroethane that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression. [PubChem]

Structure
Thumb
Synonyms
  • Mitotan
  • Mitotane
  • Mitotano
  • Mitotanum
  • Piprine-DDD, O-
External IDs
CB 313 / NSC 38721
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
LysodrenTablet500 mgOralBristol Myers Squibb1979-12-31Not applicableCanada
LysodrenTablet500 mgOralLaboratoire HRA Pharma2004-04-28Not applicableEu
LysodrenTablet500 mg/1OralE.R. Squibb & Sons, L.L.C.2009-06-01Not applicableUs
International/Other Brands
Lisodren (Bristol-Myers Squibb) / Lysodren / Opeprim (Yakult Honsha)
Categories
UNII
78E4J5IB5J
CAS number
53-19-0
Weight
Average: 320.041
Monoisotopic: 317.953661148
Chemical Formula
C14H10Cl4
InChI Key
JWBOIMRXGHLCPP-UHFFFAOYSA-N
InChI
InChI=1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H
IUPAC Name
1-chloro-4-[2,2-dichloro-1-(2-chlorophenyl)ethyl]benzene
SMILES
ClC(Cl)C(C1=CC=C(Cl)C=C1)C1=CC=CC=C1Cl

Pharmacology

Indication

For treatment of inoperable adrenocortical tumours; Cushing's syndrome

Structured Indications
Pharmacodynamics

Mitotane is an oral chemotherapeutic agent indicated in the treatment of inoperable adrenal cortical carcinoma of both functional and nonfunctional types. Mitotane can best be described as an adrenal cytotoxic agent, although it can cause adrenal inhibition, apparently without cellular destruction. The administration of Mitotane alters the extra-adrenal metabolism of cortisol in man; leading to a reduction in measurable 17-hydroxy corticosteroids, even though plasma levels of corticosteroids do not fall. The drug apparently causes increased formation of 6-B-hydroxyl cortisol.

Mechanism of action

Its biochemical mechanism of action is unknown, although data are available to suggest that the drug modifies the peripheral metabolism of steroids as well as directly suppressing the adrenal cortex.

TargetActionsOrganism
ACytochrome P450 11B1, mitochondrial
inducer
Human
UAdrenodoxin, mitochondrial
unknown
Human
UEstrogen receptor alphaNot AvailableHuman
UProgesterone receptorNot AvailableHuman
UAndrogen receptor
antagonist
Human
Absorption

About 40% oral Lysodren is absorbed

Volume of distribution
Not Available
Protein binding

6%

Metabolism

Hepatic and renal

Route of elimination

A variable amount of metabolite (1%-17%) is excreted in the bile and the balance is apparently stored in the tissues.

Half life

18-159 days

Clearance
Not Available
Toxicity
Not Available
Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
16-BromoepiandrosteroneThe serum concentration of 16-Bromoepiandrosterone can be decreased when it is combined with Mitotane.Investigational
19-norandrostenedioneThe serum concentration of 19-norandrostenedione can be decreased when it is combined with Mitotane.Experimental, Illicit
5-androstenedioneThe serum concentration of 5-androstenedione can be decreased when it is combined with Mitotane.Experimental, Illicit
AcenocoumarolThe serum concentration of Acenocoumarol can be decreased when it is combined with Mitotane.Approved
AcetaminophenThe serum concentration of Acetaminophen can be decreased when it is combined with Mitotane.Approved
AcetyldigitoxinAcetyldigitoxin may decrease the cardiotoxic activities of Mitotane.Approved
AcetyldigoxinAcetyldigoxin may decrease the cardiotoxic activities of Mitotane.Experimental
AdinazolamThe serum concentration of Adinazolam can be decreased when it is combined with Mitotane.Approved
AlbendazoleThe serum concentration of Albendazole can be decreased when it is combined with Mitotane.Approved, Vet Approved
AlclometasoneThe serum concentration of Alclometasone can be decreased when it is combined with Mitotane.Approved
AldosteroneThe serum concentration of Aldosterone can be decreased when it is combined with Mitotane.Experimental
AlfentanilThe serum concentration of Alfentanil can be decreased when it is combined with Mitotane.Approved, Illicit
AlfuzosinThe serum concentration of Alfuzosin can be decreased when it is combined with Mitotane.Approved, Investigational
AliskirenThe serum concentration of Aliskiren can be decreased when it is combined with Mitotane.Approved, Investigational
AllylestrenolThe serum concentration of Allylestrenol can be decreased when it is combined with Mitotane.Approved
AlmotriptanThe serum concentration of Almotriptan can be decreased when it is combined with Mitotane.Approved, Investigational
AlogliptinThe serum concentration of Alogliptin can be decreased when it is combined with Mitotane.Approved
AlosetronThe serum concentration of Alosetron can be decreased when it is combined with Mitotane.Approved, Withdrawn
AlprazolamThe serum concentration of Alprazolam can be decreased when it is combined with Mitotane.Approved, Illicit, Investigational
AmbrisentanThe serum concentration of Ambrisentan can be decreased when it is combined with Mitotane.Approved, Investigational
AmbroxolThe serum concentration of Ambroxol can be decreased when it is combined with Mitotane.Approved
AmcinonideThe serum concentration of Amcinonide can be decreased when it is combined with Mitotane.Approved
AminophenazoneThe serum concentration of Aminophenazone can be decreased when it is combined with Mitotane.Approved, Withdrawn
AminophyllineThe serum concentration of Aminophylline can be decreased when it is combined with Mitotane.Approved
AmiodaroneThe serum concentration of Amiodarone can be decreased when it is combined with Mitotane.Approved, Investigational
AmitriptylineThe serum concentration of Amitriptyline can be decreased when it is combined with Mitotane.Approved
AmlodipineThe serum concentration of Amlodipine can be decreased when it is combined with Mitotane.Approved
AmprenavirThe serum concentration of Amprenavir can be decreased when it is combined with Mitotane.Approved
AndrostenedioneThe serum concentration of Androstenedione can be decreased when it is combined with Mitotane.Experimental, Illicit
AnecortaveThe serum concentration of Anecortave can be decreased when it is combined with Mitotane.Investigational
anecortave acetateThe serum concentration of anecortave acetate can be decreased when it is combined with Mitotane.Investigational
AntipyrineThe serum concentration of Antipyrine can be decreased when it is combined with Mitotane.Approved
AprepitantThe serum concentration of Aprepitant can be decreased when it is combined with Mitotane.Approved, Investigational
ArgatrobanThe serum concentration of Argatroban can be decreased when it is combined with Mitotane.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Mitotane.Approved, Investigational
ArtemetherThe serum concentration of Artemether can be decreased when it is combined with Mitotane.Approved
AsenapineThe serum concentration of Asenapine can be decreased when it is combined with Mitotane.Approved
AstemizoleThe serum concentration of Astemizole can be decreased when it is combined with Mitotane.Approved, Withdrawn
AtamestaneThe serum concentration of Atamestane can be decreased when it is combined with Mitotane.Investigational
AtazanavirThe serum concentration of Atazanavir can be decreased when it is combined with Mitotane.Approved, Investigational
AtorvastatinThe serum concentration of Atorvastatin can be decreased when it is combined with Mitotane.Approved
AvanafilThe serum concentration of Avanafil can be decreased when it is combined with Mitotane.Approved
AzelastineThe serum concentration of Azelastine can be decreased when it is combined with Mitotane.Approved
AzithromycinThe serum concentration of Azithromycin can be decreased when it is combined with Mitotane.Approved
BanoxantroneThe serum concentration of Banoxantrone can be decreased when it is combined with Mitotane.Investigational
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be decreased when it is combined with Mitotane.Approved, Investigational
BenzphetamineThe serum concentration of Benzphetamine can be decreased when it is combined with Mitotane.Approved, Illicit
Benzyl alcoholThe serum concentration of Benzyl alcohol can be decreased when it is combined with Mitotane.Approved
BetamethasoneThe serum concentration of Betamethasone can be decreased when it is combined with Mitotane.Approved, Vet Approved
BevacizumabBevacizumab may increase the cardiotoxic activities of Mitotane.Approved, Investigational
BexaroteneThe serum concentration of Bexarotene can be decreased when it is combined with Mitotane.Approved, Investigational
BezafibrateThe serum concentration of Bezafibrate can be decreased when it is combined with Mitotane.Approved
BicalutamideThe serum concentration of Bicalutamide can be decreased when it is combined with Mitotane.Approved
BisoprololThe serum concentration of Bisoprolol can be decreased when it is combined with Mitotane.Approved
BosentanThe serum concentration of Bosentan can be decreased when it is combined with Mitotane.Approved, Investigational
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be decreased when it is combined with Mitotane.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be decreased when it is combined with Mitotane.Approved
BrinzolamideThe serum concentration of Brinzolamide can be decreased when it is combined with Mitotane.Approved
BrivaracetamThe serum concentration of Brivaracetam can be decreased when it is combined with Mitotane.Approved, Investigational
BromazepamThe serum concentration of Bromazepam can be decreased when it is combined with Mitotane.Approved, Illicit
BromocriptineThe serum concentration of Bromocriptine can be decreased when it is combined with Mitotane.Approved, Investigational
BrompheniramineThe serum concentration of Brompheniramine can be decreased when it is combined with Mitotane.Approved
BudesonideThe serum concentration of Budesonide can be decreased when it is combined with Mitotane.Approved
BupivacaineThe serum concentration of Bupivacaine can be decreased when it is combined with Mitotane.Approved, Investigational
BuprenorphineThe serum concentration of Buprenorphine can be decreased when it is combined with Mitotane.Approved, Illicit, Investigational, Vet Approved
BupropionThe serum concentration of Bupropion can be decreased when it is combined with Mitotane.Approved
BuspironeThe serum concentration of Buspirone can be decreased when it is combined with Mitotane.Approved, Investigational
BusulfanThe serum concentration of Busulfan can be decreased when it is combined with Mitotane.Approved, Investigational
CabazitaxelThe serum concentration of Cabazitaxel can be decreased when it is combined with Mitotane.Approved
CabergolineThe serum concentration of Cabergoline can be decreased when it is combined with Mitotane.Approved
CaffeineThe serum concentration of Caffeine can be decreased when it is combined with Mitotane.Approved
CalcitriolThe serum concentration of Calcitriol can be decreased when it is combined with Mitotane.Approved, Nutraceutical
CanagliflozinThe serum concentration of Canagliflozin can be decreased when it is combined with Mitotane.Approved
CannabidiolThe serum concentration of Cannabidiol can be decreased when it is combined with Mitotane.Approved, Investigational
CarbamazepineThe serum concentration of Carbamazepine can be decreased when it is combined with Mitotane.Approved, Investigational
CarbinoxamineThe serum concentration of Carbinoxamine can be decreased when it is combined with Mitotane.Approved
CariprazineThe serum concentration of Cariprazine can be decreased when it is combined with Mitotane.Approved
CarvedilolThe serum concentration of Carvedilol can be decreased when it is combined with Mitotane.Approved, Investigational
CelecoxibThe serum concentration of Celecoxib can be decreased when it is combined with Mitotane.Approved, Investigational
CeliprololThe serum concentration of Celiprolol can be decreased when it is combined with Mitotane.Approved, Investigational
CephalexinThe serum concentration of Cephalexin can be decreased when it is combined with Mitotane.Approved, Vet Approved
CeritinibThe serum concentration of Ceritinib can be decreased when it is combined with Mitotane.Approved
CerivastatinThe serum concentration of Cerivastatin can be decreased when it is combined with Mitotane.Withdrawn
CevimelineThe serum concentration of Cevimeline can be decreased when it is combined with Mitotane.Approved
Chenodeoxycholic acidThe serum concentration of Chenodeoxycholic acid can be decreased when it is combined with Mitotane.Approved
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Mitotane.Approved, Illicit
ChloroquineThe serum concentration of Chloroquine can be decreased when it is combined with Mitotane.Approved, Vet Approved
ChlorphenamineThe serum concentration of Chlorphenamine can be decreased when it is combined with Mitotane.Approved
ChlorpromazineThe serum concentration of Chlorpromazine can be decreased when it is combined with Mitotane.Approved, Vet Approved
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be decreased when it is combined with Mitotane.Approved
CholecalciferolThe serum concentration of Cholecalciferol can be decreased when it is combined with Mitotane.Approved, Nutraceutical
CiclesonideThe serum concentration of Ciclesonide can be decreased when it is combined with Mitotane.Approved, Investigational
CilostazolThe serum concentration of Cilostazol can be decreased when it is combined with Mitotane.Approved
CinacalcetThe serum concentration of Cinacalcet can be decreased when it is combined with Mitotane.Approved
CisaprideThe serum concentration of Cisapride can be decreased when it is combined with Mitotane.Approved, Investigational, Withdrawn
CitalopramThe serum concentration of Citalopram can be decreased when it is combined with Mitotane.Approved
ClarithromycinThe serum concentration of Clarithromycin can be decreased when it is combined with Mitotane.Approved
ClindamycinThe serum concentration of Clindamycin can be decreased when it is combined with Mitotane.Approved, Vet Approved
ClobazamThe serum concentration of Clobazam can be decreased when it is combined with Mitotane.Approved, Illicit
ClobetasolThe serum concentration of Clobetasol can be decreased when it is combined with Mitotane.Investigational
Clobetasol propionateThe serum concentration of Clobetasol propionate can be decreased when it is combined with Mitotane.Approved
ClobetasoneThe serum concentration of Clobetasone can be decreased when it is combined with Mitotane.Approved
ClocortoloneThe serum concentration of Clocortolone can be decreased when it is combined with Mitotane.Approved
ClofazimineThe serum concentration of Clofazimine can be decreased when it is combined with Mitotane.Approved, Investigational
ClofibrateThe serum concentration of Clofibrate can be decreased when it is combined with Mitotane.Approved
clomethiazoleThe serum concentration of clomethiazole can be decreased when it is combined with Mitotane.Investigational
ClomipramineThe serum concentration of Clomipramine can be decreased when it is combined with Mitotane.Approved, Vet Approved
ClonazepamThe serum concentration of Clonazepam can be decreased when it is combined with Mitotane.Approved, Illicit
ClonidineThe serum concentration of Clonidine can be decreased when it is combined with Mitotane.Approved
ClopidogrelThe serum concentration of Clopidogrel can be decreased when it is combined with Mitotane.Approved, Nutraceutical
ClorazepateThe serum concentration of Clorazepate can be decreased when it is combined with Mitotane.Approved, Illicit
ClotiazepamThe serum concentration of Clotiazepam can be decreased when it is combined with Mitotane.Approved, Illicit
CobimetinibThe serum concentration of Cobimetinib can be decreased when it is combined with Mitotane.Approved
CocaineThe serum concentration of Cocaine can be decreased when it is combined with Mitotane.Approved, Illicit
CodeineThe serum concentration of Codeine can be decreased when it is combined with Mitotane.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be decreased when it is combined with Mitotane.Approved
ConivaptanThe serum concentration of Conivaptan can be decreased when it is combined with Mitotane.Approved, Investigational
Conjugated estrogensThe serum concentration of Conjugated estrogens can be decreased when it is combined with Mitotane.Approved
CopanlisibThe serum concentration of Copanlisib can be decreased when it is combined with Mitotane.Approved
Cortexolone 17α-propionateThe serum concentration of Cortexolone 17α-propionate can be decreased when it is combined with Mitotane.Investigational
CorticosteroneThe serum concentration of Corticosterone can be decreased when it is combined with Mitotane.Experimental
Cortisone acetateThe serum concentration of Cortisone acetate can be decreased when it is combined with Mitotane.Approved
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be decreased when it is combined with Mitotane.Approved
CyclophosphamideThe serum concentration of Cyclophosphamide can be decreased when it is combined with Mitotane.Approved, Investigational
CyclosporineThe serum concentration of Cyclosporine can be decreased when it is combined with Mitotane.Approved, Investigational, Vet Approved
CymarinCymarin may decrease the cardiotoxic activities of Mitotane.Experimental
CytarabineThe serum concentration of Cytarabine can be decreased when it is combined with Mitotane.Approved, Investigational
DabrafenibThe serum concentration of Dabrafenib can be decreased when it is combined with Mitotane.Approved
DantroleneThe serum concentration of Dantrolene can be decreased when it is combined with Mitotane.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be decreased when it is combined with Mitotane.Approved
DapsoneThe serum concentration of Dapsone can be decreased when it is combined with Mitotane.Approved, Investigational
DarifenacinThe serum concentration of Darifenacin can be decreased when it is combined with Mitotane.Approved, Investigational
DarunavirThe serum concentration of Darunavir can be decreased when it is combined with Mitotane.Approved
DasabuvirThe serum concentration of Dasabuvir can be decreased when it is combined with Mitotane.Approved
DasatinibThe serum concentration of Dasatinib can be decreased when it is combined with Mitotane.Approved, Investigational
DaunorubicinThe serum concentration of Daunorubicin can be decreased when it is combined with Mitotane.Approved
DeflazacortThe serum concentration of Deflazacort can be decreased when it is combined with Mitotane.Approved
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Mitotane.Approved
DeslanosideDeslanoside may decrease the cardiotoxic activities of Mitotane.Approved
DesoximetasoneThe serum concentration of Desoximetasone can be decreased when it is combined with Mitotane.Approved
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be decreased when it is combined with Mitotane.Approved
Desoxycorticosterone PivalateThe serum concentration of Desoxycorticosterone Pivalate can be decreased when it is combined with Mitotane.Experimental, Vet Approved
DesvenlafaxineThe serum concentration of Desvenlafaxine can be decreased when it is combined with Mitotane.Approved
DeutetrabenazineThe serum concentration of Deutetrabenazine can be decreased when it is combined with Mitotane.Approved, Investigational
DexamethasoneThe serum concentration of Dexamethasone can be decreased when it is combined with Mitotane.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be decreased when it is combined with Mitotane.Vet Approved
Dexchlorpheniramine maleateThe serum concentration of Dexchlorpheniramine maleate can be decreased when it is combined with Mitotane.Approved
DexlansoprazoleThe serum concentration of Dexlansoprazole can be decreased when it is combined with Mitotane.Approved
DextromethorphanThe serum concentration of Dextromethorphan can be decreased when it is combined with Mitotane.Approved
DextropropoxypheneThe serum concentration of Dextropropoxyphene can be decreased when it is combined with Mitotane.Approved, Illicit, Withdrawn
DiazepamThe serum concentration of Diazepam can be decreased when it is combined with Mitotane.Approved, Illicit, Vet Approved
DiclofenacThe serum concentration of Diclofenac can be decreased when it is combined with Mitotane.Approved, Vet Approved
DiflorasoneThe serum concentration of Diflorasone can be decreased when it is combined with Mitotane.Approved
DifluocortoloneThe serum concentration of Difluocortolone can be decreased when it is combined with Mitotane.Approved
DifluprednateThe serum concentration of Difluprednate can be decreased when it is combined with Mitotane.Approved
DigitoxinThe serum concentration of Digitoxin can be decreased when it is combined with Mitotane.Approved
DigoxinThe serum concentration of Digoxin can be decreased when it is combined with Mitotane.Approved
DihydrocodeineThe serum concentration of Dihydrocodeine can be decreased when it is combined with Mitotane.Approved, Illicit
DihydroergotamineThe serum concentration of Dihydroergotamine can be decreased when it is combined with Mitotane.Approved
DiltiazemThe serum concentration of Diltiazem can be decreased when it is combined with Mitotane.Approved
DisopyramideThe serum concentration of Disopyramide can be decreased when it is combined with Mitotane.Approved
DisulfiramThe serum concentration of Disulfiram can be decreased when it is combined with Mitotane.Approved
DocetaxelThe serum concentration of Docetaxel can be decreased when it is combined with Mitotane.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be decreased when it is combined with Mitotane.Approved
DolasetronThe serum concentration of Dolasetron can be decreased when it is combined with Mitotane.Approved
DomperidoneThe serum concentration of Domperidone can be decreased when it is combined with Mitotane.Approved, Investigational, Vet Approved
DonepezilThe serum concentration of Donepezil can be decreased when it is combined with Mitotane.Approved
DorzolamideThe serum concentration of Dorzolamide can be decreased when it is combined with Mitotane.Approved
DoxepinThe serum concentration of Doxepin can be decreased when it is combined with Mitotane.Approved
DoxorubicinThe serum concentration of Doxorubicin can be decreased when it is combined with Mitotane.Approved, Investigational
DronabinolThe serum concentration of Dronabinol can be decreased when it is combined with Mitotane.Approved, Illicit
DutasterideThe serum concentration of Dutasteride can be decreased when it is combined with Mitotane.Approved, Investigational
EfavirenzThe serum concentration of Efavirenz can be decreased when it is combined with Mitotane.Approved, Investigational
ElbasvirThe serum concentration of Elbasvir can be decreased when it is combined with Mitotane.Approved
EletriptanThe serum concentration of Eletriptan can be decreased when it is combined with Mitotane.Approved, Investigational
ElvitegravirThe serum concentration of Elvitegravir can be decreased when it is combined with Mitotane.Approved
EnalaprilThe serum concentration of Enalapril can be decreased when it is combined with Mitotane.Approved, Vet Approved
EnasidenibThe serum concentration of Enasidenib can be decreased when it is combined with Mitotane.Approved
EpinastineThe serum concentration of Epinastine can be decreased when it is combined with Mitotane.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be decreased when it is combined with Mitotane.Approved
EquileninThe serum concentration of Equilenin can be decreased when it is combined with Mitotane.Experimental
EquilinThe serum concentration of Equilin can be decreased when it is combined with Mitotane.Approved
ErgocalciferolThe serum concentration of Ergocalciferol can be decreased when it is combined with Mitotane.Approved, Nutraceutical
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be decreased when it is combined with Mitotane.Approved
ErgonovineThe serum concentration of Ergonovine can be decreased when it is combined with Mitotane.Approved
ErgotamineThe serum concentration of Ergotamine can be decreased when it is combined with Mitotane.Approved
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with Mitotane.Approved, Investigational
ErythromycinThe serum concentration of Erythromycin can be decreased when it is combined with Mitotane.Approved, Vet Approved
EscitalopramThe serum concentration of Escitalopram can be decreased when it is combined with Mitotane.Approved, Investigational
EsomeprazoleThe serum concentration of Esomeprazole can be decreased when it is combined with Mitotane.Approved, Investigational
EstazolamThe serum concentration of Estazolam can be decreased when it is combined with Mitotane.Approved, Illicit
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Mitotane.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe serum concentration of Estradiol valerate/Dienogest can be decreased when it is combined with Mitotane.Approved
EstramustineThe serum concentration of Estramustine can be decreased when it is combined with Mitotane.Approved
Estrogens, esterifiedThe serum concentration of Estrogens, esterified can be decreased when it is combined with Mitotane.Approved
EstroneThe serum concentration of Estrone can be decreased when it is combined with Mitotane.Approved
Estrone sulfateThe serum concentration of Estrone sulfate can be decreased when it is combined with Mitotane.Approved
EszopicloneThe serum concentration of Eszopiclone can be decreased when it is combined with Mitotane.Approved
EthanolThe serum concentration of Ethanol can be decreased when it is combined with Mitotane.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Mitotane.Approved
EthosuximideThe serum concentration of Ethosuximide can be decreased when it is combined with Mitotane.Approved
EthylmorphineThe serum concentration of Ethylmorphine can be decreased when it is combined with Mitotane.Approved, Illicit
EtizolamThe serum concentration of Etizolam can be decreased when it is combined with Mitotane.Approved
EtonogestrelThe serum concentration of Etonogestrel can be decreased when it is combined with Mitotane.Approved, Investigational
EtoposideThe serum concentration of Etoposide can be decreased when it is combined with Mitotane.Approved
EtoricoxibThe serum concentration of Etoricoxib can be decreased when it is combined with Mitotane.Approved, Investigational
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Mitotane.Approved
ExemestaneThe serum concentration of Exemestane can be decreased when it is combined with Mitotane.Approved, Investigational
FamciclovirThe serum concentration of Famciclovir can be decreased when it is combined with Mitotane.Approved
FelbamateThe serum concentration of Felbamate can be decreased when it is combined with Mitotane.Approved
FelodipineThe serum concentration of Felodipine can be decreased when it is combined with Mitotane.Approved, Investigational
FenofibrateThe serum concentration of Fenofibrate can be decreased when it is combined with Mitotane.Approved
FentanylThe serum concentration of Fentanyl can be decreased when it is combined with Mitotane.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of Fesoterodine can be decreased when it is combined with Mitotane.Approved
FinasterideThe serum concentration of Finasteride can be decreased when it is combined with Mitotane.Approved
FingolimodThe serum concentration of Fingolimod can be decreased when it is combined with Mitotane.Approved, Investigational
fluasteroneThe serum concentration of fluasterone can be decreased when it is combined with Mitotane.Investigational
FludrocortisoneThe serum concentration of Fludrocortisone can be decreased when it is combined with Mitotane.Approved
FlumethasoneThe serum concentration of Flumethasone can be decreased when it is combined with Mitotane.Approved, Vet Approved
FlunisolideThe serum concentration of Flunisolide can be decreased when it is combined with Mitotane.Approved, Investigational
FlunitrazepamThe serum concentration of Flunitrazepam can be decreased when it is combined with Mitotane.Approved, Illicit
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be decreased when it is combined with Mitotane.Approved, Investigational, Vet Approved
FluocinonideThe serum concentration of Fluocinonide can be decreased when it is combined with Mitotane.Approved, Investigational
FluocortoloneThe serum concentration of Fluocortolone can be decreased when it is combined with Mitotane.Approved, Withdrawn
FluorometholoneThe serum concentration of Fluorometholone can be decreased when it is combined with Mitotane.Approved
FluoxetineThe serum concentration of Fluoxetine can be decreased when it is combined with Mitotane.Approved, Vet Approved
FluprednideneThe serum concentration of Fluprednidene can be decreased when it is combined with Mitotane.Approved, Withdrawn
FluprednisoloneThe serum concentration of Fluprednisolone can be decreased when it is combined with Mitotane.Approved
FlurandrenolideThe serum concentration of Flurandrenolide can be decreased when it is combined with Mitotane.Approved
FlurazepamThe serum concentration of Flurazepam can be decreased when it is combined with Mitotane.Approved, Illicit
FlutamideThe serum concentration of Flutamide can be decreased when it is combined with Mitotane.Approved
Fluticasone furoateThe serum concentration of Fluticasone furoate can be decreased when it is combined with Mitotane.Approved
Fluticasone propionateThe serum concentration of Fluticasone propionate can be decreased when it is combined with Mitotane.Approved
FluvastatinThe serum concentration of Fluvastatin can be decreased when it is combined with Mitotane.Approved
FormestaneThe serum concentration of Formestane can be decreased when it is combined with Mitotane.Approved, Investigational, Withdrawn
FosamprenavirThe serum concentration of Fosamprenavir can be decreased when it is combined with Mitotane.Approved
FulvestrantThe serum concentration of Fulvestrant can be decreased when it is combined with Mitotane.Approved, Investigational
GalantamineThe serum concentration of Galantamine can be decreased when it is combined with Mitotane.Approved
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with Mitotane.Approved, Investigational
GemfibrozilThe serum concentration of Gemfibrozil can be decreased when it is combined with Mitotane.Approved
GitoformateGitoformate may decrease the cardiotoxic activities of Mitotane.Experimental
GlipizideThe serum concentration of Glipizide can be decreased when it is combined with Mitotane.Approved
GlyburideThe serum concentration of Glyburide can be decreased when it is combined with Mitotane.Approved
GranisetronThe serum concentration of Granisetron can be decreased when it is combined with Mitotane.Approved, Investigational
GrazoprevirThe serum concentration of Grazoprevir can be decreased when it is combined with Mitotane.Approved
GrepafloxacinThe serum concentration of Grepafloxacin can be decreased when it is combined with Mitotane.Withdrawn
GuanfacineThe serum concentration of Guanfacine can be decreased when it is combined with Mitotane.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be decreased when it is combined with Mitotane.Approved
HaloperidolThe serum concentration of Haloperidol can be decreased when it is combined with Mitotane.Approved
HalothaneThe serum concentration of Halothane can be decreased when it is combined with Mitotane.Approved, Vet Approved
HE3286The serum concentration of HE3286 can be decreased when it is combined with Mitotane.Investigational
HexobarbitalThe serum concentration of Hexobarbital can be decreased when it is combined with Mitotane.Approved
HistamineThe serum concentration of Histamine can be decreased when it is combined with Mitotane.Approved, Investigational
HydrocodoneThe serum concentration of Hydrocodone can be decreased when it is combined with Mitotane.Approved, Illicit
HydrocortisoneThe serum concentration of Hydrocortisone can be decreased when it is combined with Mitotane.Approved, Vet Approved
HydromorphoneThe serum concentration of Hydromorphone can be decreased when it is combined with Mitotane.Approved, Illicit
Hydroxyprogesterone caproateThe serum concentration of Hydroxyprogesterone caproate can be decreased when it is combined with Mitotane.Approved
IcotinibThe serum concentration of Icotinib can be decreased when it is combined with Mitotane.Approved, Investigational
IdelalisibThe serum concentration of Idelalisib can be decreased when it is combined with Mitotane.Approved
IfosfamideThe serum concentration of Ifosfamide can be decreased when it is combined with Mitotane.Approved
IloperidoneThe serum concentration of Iloperidone can be decreased when it is combined with Mitotane.Approved
ImatinibThe serum concentration of Imatinib can be decreased when it is combined with Mitotane.Approved
ImidafenacinThe serum concentration of Imidafenacin can be decreased when it is combined with Mitotane.Approved
ImipramineThe serum concentration of Imipramine can be decreased when it is combined with Mitotane.Approved
ImiquimodThe serum concentration of Imiquimod can be decreased when it is combined with Mitotane.Approved, Investigational
IndacaterolThe serum concentration of Indacaterol can be decreased when it is combined with Mitotane.Approved
IndapamideThe serum concentration of Indapamide can be decreased when it is combined with Mitotane.Approved
IndinavirThe serum concentration of Indinavir can be decreased when it is combined with Mitotane.Approved
Ipratropium bromideThe serum concentration of Ipratropium bromide can be decreased when it is combined with Mitotane.Approved
IrinotecanThe serum concentration of Irinotecan can be decreased when it is combined with Mitotane.Approved, Investigational
IsavuconazoniumThe serum concentration of Isavuconazonium can be decreased when it is combined with Mitotane.Approved, Investigational
Isosorbide DinitrateThe serum concentration of Isosorbide Dinitrate can be decreased when it is combined with Mitotane.Approved
Isosorbide MononitrateThe serum concentration of Isosorbide Mononitrate can be decreased when it is combined with Mitotane.Approved
IsradipineThe serum concentration of Isradipine can be decreased when it is combined with Mitotane.Approved
IstaroximeThe serum concentration of Istaroxime can be decreased when it is combined with Mitotane.Investigational
IvermectinThe serum concentration of Ivermectin can be decreased when it is combined with Mitotane.Approved, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be decreased when it is combined with Mitotane.Approved, Investigational
KetamineThe serum concentration of Ketamine can be decreased when it is combined with Mitotane.Approved, Vet Approved
KetazolamThe serum concentration of Ketazolam can be decreased when it is combined with Mitotane.Approved
KetobemidoneThe serum concentration of Ketobemidone can be decreased when it is combined with Mitotane.Approved
KetoconazoleThe serum concentration of Ketoconazole can be decreased when it is combined with Mitotane.Approved, Investigational
Lanatoside CLanatoside C may decrease the cardiotoxic activities of Mitotane.Experimental
LansoprazoleThe serum concentration of Lansoprazole can be decreased when it is combined with Mitotane.Approved, Investigational
LaquinimodThe serum concentration of Laquinimod can be decreased when it is combined with Mitotane.Investigational
LenvatinibThe serum concentration of Lenvatinib can be decreased when it is combined with Mitotane.Approved
LercanidipineThe serum concentration of Lercanidipine can be decreased when it is combined with Mitotane.Approved, Investigational
LetrozoleThe serum concentration of Letrozole can be decreased when it is combined with Mitotane.Approved, Investigational
LevobupivacaineThe serum concentration of Levobupivacaine can be decreased when it is combined with Mitotane.Approved
LevocetirizineThe serum concentration of Levocetirizine can be decreased when it is combined with Mitotane.Approved
Levomethadyl AcetateThe serum concentration of Levomethadyl Acetate can be decreased when it is combined with Mitotane.Approved
LevomilnacipranThe serum concentration of Levomilnacipran can be decreased when it is combined with Mitotane.Approved
LevonorgestrelThe serum concentration of Levonorgestrel can be decreased when it is combined with Mitotane.Approved, Investigational
LevothyroxineThe serum concentration of Levothyroxine can be decreased when it is combined with Mitotane.Approved
LidocaineThe serum concentration of Lidocaine can be decreased when it is combined with Mitotane.Approved, Vet Approved
LinagliptinThe serum concentration of Linagliptin can be decreased when it is combined with Mitotane.Approved
LisurideThe serum concentration of Lisuride can be decreased when it is combined with Mitotane.Approved
LomitapideThe serum concentration of Lomitapide can be decreased when it is combined with Mitotane.Approved
LoperamideThe serum concentration of Loperamide can be decreased when it is combined with Mitotane.Approved
LopinavirThe serum concentration of Lopinavir can be decreased when it is combined with Mitotane.Approved
LoratadineThe serum concentration of Loratadine can be decreased when it is combined with Mitotane.Approved
LorcaserinThe serum concentration of Lorcaserin can be decreased when it is combined with Mitotane.Approved
LosartanThe serum concentration of Losartan can be decreased when it is combined with Mitotane.Approved
LovastatinThe serum concentration of Lovastatin can be decreased when it is combined with Mitotane.Approved, Investigational
MaravirocThe serum concentration of Maraviroc can be decreased when it is combined with Mitotane.Approved, Investigational
ME-609The serum concentration of ME-609 can be decreased when it is combined with Mitotane.Investigational
MebendazoleThe serum concentration of Mebendazole can be decreased when it is combined with Mitotane.Approved, Vet Approved
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Mitotane.Approved, Investigational
MedrysoneThe serum concentration of Medrysone can be decreased when it is combined with Mitotane.Approved
MefloquineThe serum concentration of Mefloquine can be decreased when it is combined with Mitotane.Approved
MelengestrolThe serum concentration of Melengestrol can be decreased when it is combined with Mitotane.Vet Approved
MeloxicamThe serum concentration of Meloxicam can be decreased when it is combined with Mitotane.Approved, Vet Approved
MethadoneThe serum concentration of Methadone can be decreased when it is combined with Mitotane.Approved
MethaqualoneThe serum concentration of Methaqualone can be decreased when it is combined with Mitotane.Illicit, Withdrawn
MethoxsalenThe serum concentration of Methoxsalen can be decreased when it is combined with Mitotane.Approved
MethoxyfluraneThe serum concentration of Methoxyflurane can be decreased when it is combined with Mitotane.Approved, Vet Approved
Methyl salicylateThe serum concentration of Methyl salicylate can be decreased when it is combined with Mitotane.Approved, Vet Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be decreased when it is combined with Mitotane.Approved, Vet Approved
MethyltestosteroneThe serum concentration of Methyltestosterone can be decreased when it is combined with Mitotane.Approved
MetildigoxinMetildigoxin may decrease the cardiotoxic activities of Mitotane.Experimental
MetronidazoleThe serum concentration of Metronidazole can be decreased when it is combined with Mitotane.Approved
MexiletineThe serum concentration of Mexiletine can be decreased when it is combined with Mitotane.Approved
MianserinThe serum concentration of Mianserin can be decreased when it is combined with Mitotane.Approved
MibefradilThe serum concentration of Mibefradil can be decreased when it is combined with Mitotane.Withdrawn
MiconazoleThe serum concentration of Miconazole can be decreased when it is combined with Mitotane.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Midazolam can be decreased when it is combined with Mitotane.Approved, Illicit
MidostaurinThe serum concentration of Midostaurin can be decreased when it is combined with Mitotane.Approved
MirabegronThe serum concentration of Mirabegron can be decreased when it is combined with Mitotane.Approved
MirtazapineThe serum concentration of Mirtazapine can be decreased when it is combined with Mitotane.Approved
ModafinilThe serum concentration of Modafinil can be decreased when it is combined with Mitotane.Approved, Investigational
MontelukastThe serum concentration of Montelukast can be decreased when it is combined with Mitotane.Approved
MorphineThe serum concentration of Morphine can be decreased when it is combined with Mitotane.Approved, Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be decreased when it is combined with Mitotane.Approved, Investigational
NaloxoneThe serum concentration of Naloxone can be decreased when it is combined with Mitotane.Approved, Vet Approved
NateglinideThe serum concentration of Nateglinide can be decreased when it is combined with Mitotane.Approved, Investigational
NCX 1022The serum concentration of NCX 1022 can be decreased when it is combined with Mitotane.Investigational
NefazodoneThe serum concentration of Nefazodone can be decreased when it is combined with Mitotane.Approved, Withdrawn
NelfinavirThe serum concentration of Nelfinavir can be decreased when it is combined with Mitotane.Approved
NeratinibThe serum concentration of Neratinib can be decreased when it is combined with Mitotane.Approved, Investigational
NetupitantThe serum concentration of Netupitant can be decreased when it is combined with Mitotane.Approved
NevirapineThe serum concentration of Nevirapine can be decreased when it is combined with Mitotane.Approved
NicardipineThe serum concentration of Nicardipine can be decreased when it is combined with Mitotane.Approved
NicotineThe serum concentration of Nicotine can be decreased when it is combined with Mitotane.Approved
NilvadipineThe serum concentration of Nilvadipine can be decreased when it is combined with Mitotane.Approved
NitrazepamThe serum concentration of Nitrazepam can be decreased when it is combined with Mitotane.Approved
NitrendipineThe serum concentration of Nitrendipine can be decreased when it is combined with Mitotane.Approved
NorethisteroneThe serum concentration of Norethisterone can be decreased when it is combined with Mitotane.Approved
NorgestrelThe serum concentration of Norgestrel can be decreased when it is combined with Mitotane.Approved
NortriptylineThe serum concentration of Nortriptyline can be decreased when it is combined with Mitotane.Approved
OdanacatibThe serum concentration of Odanacatib can be decreased when it is combined with Mitotane.Investigational
OleandrinOleandrin may decrease the cardiotoxic activities of Mitotane.Experimental
Oleoyl-estroneThe serum concentration of Oleoyl-estrone can be decreased when it is combined with Mitotane.Investigational
OlopatadineThe serum concentration of Olopatadine can be decreased when it is combined with Mitotane.Approved
OmeprazoleThe serum concentration of Omeprazole can be decreased when it is combined with Mitotane.Approved, Investigational, Vet Approved
OndansetronThe serum concentration of Ondansetron can be decreased when it is combined with Mitotane.Approved
OrphenadrineThe serum concentration of Orphenadrine can be decreased when it is combined with Mitotane.Approved
OsimertinibThe serum concentration of Osimertinib can be decreased when it is combined with Mitotane.Approved
OspemifeneThe serum concentration of Ospemifene can be decreased when it is combined with Mitotane.Approved
OuabainOuabain may decrease the cardiotoxic activities of Mitotane.Approved
OxazepamThe serum concentration of Oxazepam can be decreased when it is combined with Mitotane.Approved
OxybutyninThe serum concentration of Oxybutynin can be decreased when it is combined with Mitotane.Approved, Investigational
OxycodoneThe serum concentration of Oxycodone can be decreased when it is combined with Mitotane.Approved, Illicit, Investigational
OxymorphoneThe serum concentration of Oxymorphone can be decreased when it is combined with Mitotane.Approved, Investigational, Vet Approved
PaclitaxelThe serum concentration of Paclitaxel can be decreased when it is combined with Mitotane.Approved, Vet Approved
PalonosetronThe serum concentration of Palonosetron can be decreased when it is combined with Mitotane.Approved, Investigational
PantoprazoleThe serum concentration of Pantoprazole can be decreased when it is combined with Mitotane.Approved
ParamethadioneThe serum concentration of Paramethadione can be decreased when it is combined with Mitotane.Approved
ParamethasoneThe serum concentration of Paramethasone can be decreased when it is combined with Mitotane.Approved
ParecoxibThe serum concentration of Parecoxib can be decreased when it is combined with Mitotane.Approved
ParicalcitolThe serum concentration of Paricalcitol can be decreased when it is combined with Mitotane.Approved, Investigational
ParitaprevirThe serum concentration of Paritaprevir can be decreased when it is combined with Mitotane.Approved
PentamidineThe serum concentration of Pentamidine can be decreased when it is combined with Mitotane.Approved
PergolideThe serum concentration of Pergolide can be decreased when it is combined with Mitotane.Approved, Vet Approved, Withdrawn
PerhexilineThe serum concentration of Perhexiline can be decreased when it is combined with Mitotane.Approved
PermethrinThe serum concentration of Permethrin can be decreased when it is combined with Mitotane.Approved, Investigational
PerospironeThe serum concentration of Perospirone can be decreased when it is combined with Mitotane.Approved
PerphenazineThe serum concentration of Perphenazine can be decreased when it is combined with Mitotane.Approved
PeruvosidePeruvoside may decrease the cardiotoxic activities of Mitotane.Experimental
PethidineThe serum concentration of Pethidine can be decreased when it is combined with Mitotane.Approved
PhenacetinThe serum concentration of Phenacetin can be decreased when it is combined with Mitotane.Withdrawn
PhenoxybenzamineThe serum concentration of Phenoxybenzamine can be decreased when it is combined with Mitotane.Approved
PhenprocoumonThe serum concentration of Phenprocoumon can be decreased when it is combined with Mitotane.Approved
PhenytoinThe serum concentration of Phenytoin can be decreased when it is combined with Mitotane.Approved, Vet Approved
PilocarpineThe serum concentration of Pilocarpine can be decreased when it is combined with Mitotane.Approved
PimecrolimusThe serum concentration of Pimecrolimus can be decreased when it is combined with Mitotane.Approved, Investigational
PimozideThe serum concentration of Pimozide can be decreased when it is combined with Mitotane.Approved
PinacidilThe serum concentration of Pinacidil can be decreased when it is combined with Mitotane.Withdrawn
PioglitazoneThe serum concentration of Pioglitazone can be decreased when it is combined with Mitotane.Approved, Investigational
PipotiazineThe serum concentration of Pipotiazine can be decreased when it is combined with Mitotane.Approved
PodofiloxThe serum concentration of Podofilox can be decreased when it is combined with Mitotane.Approved
PomalidomideThe serum concentration of Pomalidomide can be decreased when it is combined with Mitotane.Approved
PosaconazoleThe serum concentration of Posaconazole can be decreased when it is combined with Mitotane.Approved, Investigational, Vet Approved
PrasteroneThe serum concentration of Prasterone can be decreased when it is combined with Mitotane.Approved, Nutraceutical
Prasterone sulfateThe serum concentration of Prasterone sulfate can be decreased when it is combined with Mitotane.Investigational
PrasugrelThe serum concentration of Prasugrel can be decreased when it is combined with Mitotane.Approved
PravastatinThe serum concentration of Pravastatin can be decreased when it is combined with Mitotane.Approved
PrazepamThe serum concentration of Prazepam can be decreased when it is combined with Mitotane.Approved, Illicit
PrednicarbateThe serum concentration of Prednicarbate can be decreased when it is combined with Mitotane.Approved
PrednisoloneThe serum concentration of Prednisolone can be decreased when it is combined with Mitotane.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be decreased when it is combined with Mitotane.Approved, Vet Approved
PregnenoloneThe serum concentration of Pregnenolone can be decreased when it is combined with Mitotane.Experimental
PrimaquineThe serum concentration of Primaquine can be decreased when it is combined with Mitotane.Approved
ProchlorperazineThe serum concentration of Prochlorperazine can be decreased when it is combined with Mitotane.Approved, Vet Approved
ProgesteroneThe serum concentration of Progesterone can be decreased when it is combined with Mitotane.Approved, Vet Approved
ProguanilThe serum concentration of Proguanil can be decreased when it is combined with Mitotane.Approved
PromazineThe serum concentration of Promazine can be decreased when it is combined with Mitotane.Approved, Vet Approved
PropafenoneThe serum concentration of Propafenone can be decreased when it is combined with Mitotane.Approved
PropofolThe serum concentration of Propofol can be decreased when it is combined with Mitotane.Approved, Investigational, Vet Approved
Propoxyphene napsylateThe serum concentration of Propoxyphene napsylate can be decreased when it is combined with Mitotane.Approved
PropranololThe serum concentration of Propranolol can be decreased when it is combined with Mitotane.Approved, Investigational
ProscillaridinProscillaridin may decrease the cardiotoxic activities of Mitotane.Experimental
PyrazinamideThe serum concentration of Pyrazinamide can be decreased when it is combined with Mitotane.Approved
QuazepamThe serum concentration of Quazepam can be decreased when it is combined with Mitotane.Approved, Illicit
QuetiapineThe serum concentration of Quetiapine can be decreased when it is combined with Mitotane.Approved
QuinacrineThe serum concentration of Quinacrine can be decreased when it is combined with Mitotane.Approved
QuinidineThe serum concentration of Quinidine can be decreased when it is combined with Mitotane.Approved
QuinineThe serum concentration of Quinine can be decreased when it is combined with Mitotane.Approved
RabeprazoleThe serum concentration of Rabeprazole can be decreased when it is combined with Mitotane.Approved, Investigational
RaloxifeneThe serum concentration of Raloxifene can be decreased when it is combined with Mitotane.Approved, Investigational
RamelteonThe serum concentration of Ramelteon can be decreased when it is combined with Mitotane.Approved, Investigational
ReboxetineThe serum concentration of Reboxetine can be decreased when it is combined with Mitotane.Approved, Investigational
RepaglinideThe serum concentration of Repaglinide can be decreased when it is combined with Mitotane.Approved, Investigational
RetapamulinThe serum concentration of Retapamulin can be decreased when it is combined with Mitotane.Approved
RifabutinThe serum concentration of Rifabutin can be decreased when it is combined with Mitotane.Approved
RifampicinThe serum concentration of Rifampicin can be decreased when it is combined with Mitotane.Approved
RilpivirineThe serum concentration of Rilpivirine can be decreased when it is combined with Mitotane.Approved
RimexoloneThe serum concentration of Rimexolone can be decreased when it is combined with Mitotane.Approved
RimonabantThe serum concentration of Rimonabant can be decreased when it is combined with Mitotane.Approved, Investigational
RiociguatThe serum concentration of Riociguat can be decreased when it is combined with Mitotane.Approved
RisperidoneThe serum concentration of Risperidone can be decreased when it is combined with Mitotane.Approved, Investigational
RitonavirThe serum concentration of Ritonavir can be decreased when it is combined with Mitotane.Approved, Investigational
RofecoxibThe serum concentration of Rofecoxib can be decreased when it is combined with Mitotane.Investigational, Withdrawn
RoflumilastThe serum concentration of Roflumilast can be decreased when it is combined with Mitotane.Approved
RolapitantThe serum concentration of Rolapitant can be decreased when it is combined with Mitotane.Approved
RopiniroleThe serum concentration of Ropinirole can be decreased when it is combined with Mitotane.Approved, Investigational
RopivacaineThe serum concentration of Ropivacaine can be decreased when it is combined with Mitotane.Approved
RosuvastatinThe serum concentration of Rosuvastatin can be decreased when it is combined with Mitotane.Approved
RotigotineThe serum concentration of Rotigotine can be decreased when it is combined with Mitotane.Approved
RoxithromycinThe serum concentration of Roxithromycin can be decreased when it is combined with Mitotane.Approved, Withdrawn
RucaparibThe serum concentration of Rucaparib can be decreased when it is combined with Mitotane.Approved, Investigational
RupatadineThe serum concentration of Rupatadine can be decreased when it is combined with Mitotane.Approved
RuxolitinibThe serum concentration of Ruxolitinib can be decreased when it is combined with Mitotane.Approved
SafinamideThe serum concentration of Safinamide can be decreased when it is combined with Mitotane.Approved
SalmeterolThe serum concentration of Salmeterol can be decreased when it is combined with Mitotane.Approved
SaquinavirThe serum concentration of Saquinavir can be decreased when it is combined with Mitotane.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Mitotane.Approved
SelegilineThe serum concentration of Selegiline can be decreased when it is combined with Mitotane.Approved, Investigational, Vet Approved
SelexipagThe serum concentration of Selexipag can be decreased when it is combined with Mitotane.Approved
SeratrodastThe serum concentration of Seratrodast can be decreased when it is combined with Mitotane.Approved
SertindoleThe serum concentration of Sertindole can be decreased when it is combined with Mitotane.Approved, Withdrawn
SertralineThe serum concentration of Sertraline can be decreased when it is combined with Mitotane.Approved
SevofluraneThe serum concentration of Sevoflurane can be decreased when it is combined with Mitotane.Approved, Vet Approved
SibutramineThe serum concentration of Sibutramine can be decreased when it is combined with Mitotane.Approved, Illicit, Investigational, Withdrawn
SildenafilThe serum concentration of Sildenafil can be decreased when it is combined with Mitotane.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be decreased when it is combined with Mitotane.Approved
SimvastatinThe serum concentration of Simvastatin can be decreased when it is combined with Mitotane.Approved
SirolimusThe serum concentration of Sirolimus can be decreased when it is combined with Mitotane.Approved, Investigational
SitagliptinThe serum concentration of Sitagliptin can be decreased when it is combined with Mitotane.Approved, Investigational
SolifenacinThe serum concentration of Solifenacin can be decreased when it is combined with Mitotane.Approved
SpiramycinThe serum concentration of Spiramycin can be decreased when it is combined with Mitotane.Approved
SpironolactoneThe therapeutic efficacy of Mitotane can be decreased when used in combination with Spironolactone.Approved
SufentanilThe serum concentration of Sufentanil can be decreased when it is combined with Mitotane.Approved, Investigational
SulfadiazineThe serum concentration of Sulfadiazine can be decreased when it is combined with Mitotane.Approved, Vet Approved
SulfamethoxazoleThe serum concentration of Sulfamethoxazole can be decreased when it is combined with Mitotane.Approved
SulfinpyrazoneThe serum concentration of Sulfinpyrazone can be decreased when it is combined with Mitotane.Approved
SunitinibThe serum concentration of Sunitinib can be decreased when it is combined with Mitotane.Approved, Investigational
SuvorexantThe serum concentration of Suvorexant can be decreased when it is combined with Mitotane.Approved
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be decreased when it is combined with Mitotane.Approved
Synthetic Conjugated Estrogens, BThe serum concentration of Synthetic Conjugated Estrogens, B can be decreased when it is combined with Mitotane.Approved
TacrolimusThe serum concentration of Tacrolimus can be decreased when it is combined with Mitotane.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be decreased when it is combined with Mitotane.Approved, Investigational
TamoxifenThe serum concentration of Tamoxifen can be decreased when it is combined with Mitotane.Approved
TamsulosinThe serum concentration of Tamsulosin can be decreased when it is combined with Mitotane.Approved, Investigational
TasimelteonThe serum concentration of Tasimelteon can be decreased when it is combined with Mitotane.Approved
TasosartanThe serum concentration of Tasosartan can be decreased when it is combined with Mitotane.Approved
Taurochenodeoxycholic acidThe serum concentration of Taurochenodeoxycholic acid can be decreased when it is combined with Mitotane.Experimental
TelithromycinThe serum concentration of Telithromycin can be decreased when it is combined with Mitotane.Approved
TemazepamThe serum concentration of Temazepam can be decreased when it is combined with Mitotane.Approved
TemsirolimusThe serum concentration of Temsirolimus can be decreased when it is combined with Mitotane.Approved
TeniposideThe serum concentration of Teniposide can be decreased when it is combined with Mitotane.Approved
TerbinafineThe serum concentration of Terbinafine can be decreased when it is combined with Mitotane.Approved, Investigational, Vet Approved
TerfenadineThe serum concentration of Terfenadine can be decreased when it is combined with Mitotane.Withdrawn
TesmilifeneThe serum concentration of Tesmilifene can be decreased when it is combined with Mitotane.Investigational
TestosteroneThe serum concentration of Testosterone can be decreased when it is combined with Mitotane.Approved, Investigational
TetracyclineThe serum concentration of Tetracycline can be decreased when it is combined with Mitotane.Approved, Vet Approved
TheophyllineThe serum concentration of Theophylline can be decreased when it is combined with Mitotane.Approved
ThiotepaThe serum concentration of Thiotepa can be decreased when it is combined with Mitotane.Approved
TiagabineThe serum concentration of Tiagabine can be decreased when it is combined with Mitotane.Approved
TicagrelorThe serum concentration of Ticagrelor can be decreased when it is combined with Mitotane.Approved
TiclopidineThe serum concentration of Ticlopidine can be decreased when it is combined with Mitotane.Approved
TinidazoleThe serum concentration of Tinidazole can be decreased when it is combined with Mitotane.Approved, Investigational
TiotropiumThe serum concentration of Tiotropium can be decreased when it is combined with Mitotane.Approved
TipranavirThe serum concentration of Tipranavir can be decreased when it is combined with Mitotane.Approved, Investigational
TixocortolThe serum concentration of Tixocortol can be decreased when it is combined with Mitotane.Approved
TolterodineThe serum concentration of Tolterodine can be decreased when it is combined with Mitotane.Approved, Investigational
TramadolThe serum concentration of Tramadol can be decreased when it is combined with Mitotane.Approved, Investigational
TrastuzumabTrastuzumab may increase the cardiotoxic activities of Mitotane.Approved, Investigational
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be decreased when it is combined with Mitotane.Approved
TrazodoneThe serum concentration of Trazodone can be decreased when it is combined with Mitotane.Approved, Investigational
TretinoinThe serum concentration of Tretinoin can be decreased when it is combined with Mitotane.Approved, Investigational, Nutraceutical
TriamcinoloneThe serum concentration of Triamcinolone can be decreased when it is combined with Mitotane.Approved, Vet Approved
TriazolamThe serum concentration of Triazolam can be decreased when it is combined with Mitotane.Approved
TrimethadioneThe serum concentration of Trimethadione can be decreased when it is combined with Mitotane.Approved
TrimethoprimThe serum concentration of Trimethoprim can be decreased when it is combined with Mitotane.Approved, Vet Approved
TrimipramineThe serum concentration of Trimipramine can be decreased when it is combined with Mitotane.Approved
TroglitazoneThe serum concentration of Troglitazone can be decreased when it is combined with Mitotane.Withdrawn
TroleandomycinThe serum concentration of Troleandomycin can be decreased when it is combined with Mitotane.Approved
UdenafilThe serum concentration of Udenafil can be decreased when it is combined with Mitotane.Approved, Investigational
ValbenazineThe serum concentration of Valbenazine can be decreased when it is combined with Mitotane.Approved, Investigational
ValdecoxibThe serum concentration of Valdecoxib can be decreased when it is combined with Mitotane.Investigational, Withdrawn
VanoxerineThe serum concentration of Vanoxerine can be decreased when it is combined with Mitotane.Investigational
VardenafilThe serum concentration of Vardenafil can be decreased when it is combined with Mitotane.Approved
VelpatasvirThe serum concentration of Velpatasvir can be decreased when it is combined with Mitotane.Approved
VenetoclaxThe serum concentration of Venetoclax can be decreased when it is combined with Mitotane.Approved
VenlafaxineThe serum concentration of Venlafaxine can be decreased when it is combined with Mitotane.Approved
VerapamilThe serum concentration of Verapamil can be decreased when it is combined with Mitotane.Approved
VicrivirocThe serum concentration of Vicriviroc can be decreased when it is combined with Mitotane.Investigational
VilanterolThe serum concentration of Vilanterol can be decreased when it is combined with Mitotane.Approved
VilazodoneThe serum concentration of Vilazodone can be decreased when it is combined with Mitotane.Approved
VinblastineThe serum concentration of Vinblastine can be decreased when it is combined with Mitotane.Approved
VincristineThe serum concentration of Vincristine can be decreased when it is combined with Mitotane.Approved, Investigational
VindesineThe serum concentration of Vindesine can be decreased when it is combined with Mitotane.Approved
VinorelbineThe serum concentration of Vinorelbine can be decreased when it is combined with Mitotane.Approved, Investigational
VismodegibThe serum concentration of Vismodegib can be decreased when it is combined with Mitotane.Approved
VorapaxarThe serum concentration of Vorapaxar can be decreased when it is combined with Mitotane.Approved
VoriconazoleThe serum concentration of Voriconazole can be decreased when it is combined with Mitotane.Approved, Investigational
VortioxetineThe serum concentration of Vortioxetine can be decreased when it is combined with Mitotane.Approved
VoxilaprevirThe serum concentration of Voxilaprevir can be decreased when it is combined with Mitotane.Approved
WarfarinThe serum concentration of Warfarin can be decreased when it is combined with Mitotane.Approved
YohimbineThe serum concentration of Yohimbine can be decreased when it is combined with Mitotane.Approved, Vet Approved
ZafirlukastThe serum concentration of Zafirlukast can be decreased when it is combined with Mitotane.Approved, Investigational
ZalcitabineThe serum concentration of Zalcitabine can be decreased when it is combined with Mitotane.Approved
ZaleplonThe serum concentration of Zaleplon can be decreased when it is combined with Mitotane.Approved, Illicit, Investigational
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Mitotane.Approved
ZileutonThe serum concentration of Zileuton can be decreased when it is combined with Mitotane.Approved, Investigational, Withdrawn
ZiprasidoneThe serum concentration of Ziprasidone can be decreased when it is combined with Mitotane.Approved
ZolpidemThe serum concentration of Zolpidem can be decreased when it is combined with Mitotane.Approved
ZomepiracThe serum concentration of Zomepirac can be decreased when it is combined with Mitotane.Withdrawn
ZonisamideThe serum concentration of Zonisamide can be decreased when it is combined with Mitotane.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be decreased when it is combined with Mitotane.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be decreased when it is combined with Mitotane.Approved, Investigational
Food Interactions
  • Take without regard to meals.

References

General References
Not Available
External Links
Human Metabolome Database
HMDB14786
KEGG Drug
D00420
PubChem Compound
4211
PubChem Substance
46508319
ChemSpider
4066
ChEBI
6954
ChEMBL
CHEMBL1670
Therapeutic Targets Database
DAP000033
PharmGKB
PA164746157
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Mitotane
ATC Codes
L01XX23 — Mitotane
AHFS Codes
  • 10:00.00 — Antineoplastic Agents
MSDS
Download (57 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedTreatmentProstate Cancer1
2TerminatedTreatmentRecurrent Adrenocortical Carcinoma / Stage III Adrenocortical Carcinoma / Stage IV Adrenocortical Carcinoma1
3Active Not RecruitingTreatmentStage I Adrenocortical Carcinoma / Stage II Adrenocortical Carcinoma / Stage III Adrenocortical Carcinoma / Stage IV Adrenocortical Carcinoma1
3CompletedTreatmentCarcinoma, Adrenal Cortical1
3Unknown StatusTreatmentAdrenocortical Carcinoma1

Pharmacoeconomics

Manufacturers
  • Bristol myers squibb
Packagers
Dosage forms
FormRouteStrength
TabletOral500 mg
TabletOral500 mg/1
Prices
Unit descriptionCostUnit
Mitotane powder7.75USD g
Lysodren 500 mg tablet5.13USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)77 °CPhysProp
water solubility0.1 mg/L (at 25 °C)BIGGAR,JW & RIGGS,RI (1974)
logP6Not Available
logS-6.51ADME Research, USCD
Predicted Properties
PropertyValueSource
Water Solubility9.42e-06 mg/mLALOGPS
logP6.08ALOGPS
logP6.11ChemAxon
logS-7.5ALOGPS
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity79.97 m3·mol-1ChemAxon
Polarizability29.93 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9942
Blood Brain Barrier+0.9905
Caco-2 permeable+0.8815
P-glycoprotein substrateNon-substrate0.8053
P-glycoprotein inhibitor INon-inhibitor0.9004
P-glycoprotein inhibitor IINon-inhibitor0.988
Renal organic cation transporterNon-inhibitor0.7959
CYP450 2C9 substrateNon-substrate0.7899
CYP450 2D6 substrateNon-substrate0.818
CYP450 3A4 substrateNon-substrate0.7045
CYP450 1A2 substrateInhibitor0.9542
CYP450 2C9 inhibitorInhibitor0.7241
CYP450 2D6 inhibitorNon-inhibitor0.9349
CYP450 2C19 inhibitorInhibitor0.8993
CYP450 3A4 inhibitorNon-inhibitor0.8629
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.8
Ames testNon AMES toxic0.9751
CarcinogenicityNon-carcinogens0.575
BiodegradationNot ready biodegradable0.9596
Rat acute toxicity2.1911 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9221
hERG inhibition (predictor II)Non-inhibitor0.875
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Download (8.84 KB)
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
GC-MS Spectrum - GC-EI-QGC-MSsplash10-000i-2590000000-2d3f8090ffa4733bf9ee
Mass Spectrum (Electron Ionization)MSsplash10-000i-2690000000-770065ddc57899130a31
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
1H NMR Spectrum1D NMRNot Applicable
13C NMR Spectrum1D NMRNot Applicable

Taxonomy

Description
This compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Diphenylmethanes
Direct Parent
Diphenylmethanes
Alternative Parents
Chlorobenzenes / Aryl chlorides / Organochlorides / Hydrocarbon derivatives / Alkyl chlorides
Substituents
Diphenylmethane / Halobenzene / Chlorobenzene / Aryl halide / Aryl chloride / Hydrocarbon derivative / Organochloride / Organohalogen compound / Alkyl halide / Alkyl chloride
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
Not Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inducer
General Function
Steroid 11-beta-monooxygenase activity
Specific Function
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochro...
Gene Name
CYP11B1
Uniprot ID
P15538
Uniprot Name
Cytochrome P450 11B1, mitochondrial
Molecular Weight
57572.44 Da
References
  1. Lindhe O, Skogseid B, Brandt I: Cytochrome P450-catalyzed binding of 3-methylsulfonyl-DDE and o,p'-DDD in human adrenal zona fasciculata/reticularis. J Clin Endocrinol Metab. 2002 Mar;87(3):1319-26. [PubMed:11889204]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Unknown
General Function
Iron ion binding
Specific Function
Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Trans...
Gene Name
FDX1
Uniprot ID
P10109
Uniprot Name
Adrenodoxin, mitochondrial
Molecular Weight
19392.475 Da
References
  1. Kandul SV, Iatsyk MI, Kononenko VIa: [Comparative study of the effect of chloditan on the concentration of cytochrome P-450 and adrenodoxin in various organs of the dog and rat]. Fiziol Zh. 1986 Sep-Oct;32(5):579-84. [PubMed:3770229]
  2. Cabrini DA, Campos MM, Tratsk KS, Merino VF, Silva JA Jr, Souza GE, Avellar MC, Pesquero JB, Calixto JB: Molecular and pharmacological evidence for modulation of kinin B(1) receptor expression by endogenous glucocorticoids hormones in rats. Br J Pharmacol. 2001 Jan;132(2):567-77. [PubMed:11159707]
  3. Cai W, Counsell RE, Schteingart DE, Sinsheimer JE, Vaz AD, Wotring LL: Adrenal proteins bound by a reactive intermediate of mitotane. Cancer Chemother Pharmacol. 1997;39(6):537-40. [PubMed:9118466]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Zinc ion binding
Specific Function
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissu...
Gene Name
ESR1
Uniprot ID
P03372
Uniprot Name
Estrogen receptor
Molecular Weight
66215.45 Da
References
  1. Scippo ML, Argiris C, Van De Weerdt C, Muller M, Willemsen P, Martial J, Maghuin-Rogister G: Recombinant human estrogen, androgen and progesterone receptors for detection of potential endocrine disruptors. Anal Bioanal Chem. 2004 Feb;378(3):664-9. Epub 2003 Oct 25. [PubMed:14579009]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Zinc ion binding
Specific Function
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor ...
Gene Name
PGR
Uniprot ID
P06401
Uniprot Name
Progesterone receptor
Molecular Weight
98979.96 Da
References
  1. Scippo ML, Argiris C, Van De Weerdt C, Muller M, Willemsen P, Martial J, Maghuin-Rogister G: Recombinant human estrogen, androgen and progesterone receptors for detection of potential endocrine disruptors. Anal Bioanal Chem. 2004 Feb;378(3):664-9. Epub 2003 Oct 25. [PubMed:14579009]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Antagonist
General Function
Zinc ion binding
Specific Function
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription ...
Gene Name
AR
Uniprot ID
P10275
Uniprot Name
Androgen receptor
Molecular Weight
98987.9 Da
References
  1. Maness SC, McDonnell DP, Gaido KW: Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells. Toxicol Appl Pharmacol. 1998 Jul;151(1):135-42. [PubMed:9705896]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inducer
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da

Carriers

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Androgen binding
Specific Function
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone...
Gene Name
SHBG
Uniprot ID
P04278
Uniprot Name
Sex hormone-binding globulin
Molecular Weight
43778.755 Da
References
  1. Nader N, Raverot G, Emptoz-Bonneton A, Dechaud H, Bonnay M, Baudin E, Pugeat M: Mitotane has an estrogenic effect on sex hormone-binding globulin and corticosteroid-binding globulin in humans. J Clin Endocrinol Metab. 2006 Jun;91(6):2165-70. Epub 2006 Mar 21. [PubMed:16551731]
  2. van Seters AP, Moolenaar AJ: Mitotane increases the blood levels of hormone-binding proteins. Acta Endocrinol (Copenh). 1991 May;124(5):526-33. [PubMed:1903011]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Steroid binding
Specific Function
Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
Gene Name
SERPINA6
Uniprot ID
P08185
Uniprot Name
Corticosteroid-binding globulin
Molecular Weight
45140.49 Da
References
  1. Nader N, Raverot G, Emptoz-Bonneton A, Dechaud H, Bonnay M, Baudin E, Pugeat M: Mitotane has an estrogenic effect on sex hormone-binding globulin and corticosteroid-binding globulin in humans. J Clin Endocrinol Metab. 2006 Jun;91(6):2165-70. Epub 2006 Mar 21. [PubMed:16551731]
  2. Tron'ko MD: [Effect of chlodithane (o,p'-DDD) on transcortin binding ability in Itsenko-Cushing's disease]. Fiziol Zh. 1970 Nov-Dec;16(6):844-5. [PubMed:5520073]

Drug created on June 13, 2005 07:24 / Updated on October 21, 2017 19:24