You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on DrugBank.
Identification
NameMitotane
Accession NumberDB00648  (APRD00494)
TypeSmall Molecule
GroupsApproved
DescriptionA derivative of the insecticide dichlorodiphenyldichloroethane that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression. [PubChem]
Structure
Thumb
Synonyms
Lysodren
Mitotan
Mitotane
Mitotano
Mitotanum
Piprine-DDD, O-
External Identifiers
  • CB 313
  • NSC 38721
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
LysodrenTablet500 mg/1OralE.R. Squibb & Sons, L.L.C.2009-06-01Not applicableUs
LysodrenTablet500 mgOralBristol Myers Squibb Canada1979-12-31Not applicableCanada
LysodrenTablet500 mgOralLaboratoire HRA Pharma2004-04-28Not applicableEu
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
LisodrenBristol-Myers Squibb
OpeprimYakult Honsha
Brand mixturesNot Available
SaltsNot Available
Categories
UNII78E4J5IB5J
CAS number53-19-0
WeightAverage: 320.041
Monoisotopic: 317.953661148
Chemical FormulaC14H10Cl4
InChI KeyJWBOIMRXGHLCPP-UHFFFAOYSA-N
InChI
InChI=1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H
IUPAC Name
1-chloro-4-[2,2-dichloro-1-(2-chlorophenyl)ethyl]benzene
SMILES
ClC(Cl)C(C1=CC=C(Cl)C=C1)C1=CC=CC=C1Cl
Pharmacology
IndicationFor treatment of inoperable adrenocortical tumours; Cushing's syndrome
Structured Indications
PharmacodynamicsMitotane is an oral chemotherapeutic agent indicated in the treatment of inoperable adrenal cortical carcinoma of both functional and nonfunctional types. Mitotane can best be described as an adrenal cytotoxic agent, although it can cause adrenal inhibition, apparently without cellular destruction. The administration of Mitotane alters the extra-adrenal metabolism of cortisol in man; leading to a reduction in measurable 17-hydroxy corticosteroids, even though plasma levels of corticosteroids do not fall. The drug apparently causes increased formation of 6-B-hydroxyl cortisol.
Mechanism of actionIts biochemical mechanism of action is unknown, although data are available to suggest that the drug modifies the peripheral metabolism of steroids as well as directly suppressing the adrenal cortex.
TargetKindPharmacological actionActionsOrganismUniProt ID
Cytochrome P450 11B1, mitochondrialProteinyes
inducer
HumanP15538 details
Adrenodoxin, mitochondrialProteinunknown
unknown
HumanP10109 details
Related Articles
AbsorptionAbout 40% oral Lysodren is absorbed
Volume of distributionNot Available
Protein binding6%
Metabolism

Hepatic and renal

Route of eliminationA variable amount of metabolite (1%-17%) is excreted in the bile and the balance is apparently stored in the tissues.
Half life18-159 days
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
16-BromoepiandrosteroneThe serum concentration of 16-Bromoepiandrosterone can be decreased when it is combined with Mitotane.Investigational
19-norandrostenedioneThe serum concentration of 19-norandrostenedione can be decreased when it is combined with Mitotane.Experimental, Illicit
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be decreased when it is combined with Mitotane.Experimental, Illicit
5-androstenedioneThe serum concentration of 5-androstenedione can be decreased when it is combined with Mitotane.Experimental, Illicit
AbirateroneThe serum concentration of Abiraterone can be decreased when it is combined with Mitotane.Approved
AcenocoumarolThe serum concentration of Acenocoumarol can be decreased when it is combined with Mitotane.Approved
AcetaminophenThe serum concentration of Acetaminophen can be decreased when it is combined with Mitotane.Approved
AcetyldigitoxinAcetyldigitoxin may decrease the cardiotoxic activities of Mitotane.Approved
AdinazolamThe serum concentration of Adinazolam can be decreased when it is combined with Mitotane.Approved
AlbendazoleThe serum concentration of Albendazole can be decreased when it is combined with Mitotane.Approved, Vet Approved
AlclometasoneThe serum concentration of Alclometasone can be decreased when it is combined with Mitotane.Approved
AldosteroneThe serum concentration of Aldosterone can be decreased when it is combined with Mitotane.Experimental
AlfentanilThe serum concentration of Alfentanil can be decreased when it is combined with Mitotane.Approved, Illicit
AlfuzosinThe serum concentration of Alfuzosin can be decreased when it is combined with Mitotane.Approved, Investigational
AliskirenThe serum concentration of Aliskiren can be decreased when it is combined with Mitotane.Approved, Investigational
AllylestrenolThe serum concentration of Allylestrenol can be decreased when it is combined with Mitotane.Approved
AlmotriptanThe serum concentration of Almotriptan can be decreased when it is combined with Mitotane.Approved, Investigational
AlogliptinThe serum concentration of Alogliptin can be decreased when it is combined with Mitotane.Approved
AlosetronThe serum concentration of Alosetron can be decreased when it is combined with Mitotane.Approved, Withdrawn
AlprazolamThe serum concentration of Alprazolam can be decreased when it is combined with Mitotane.Approved, Illicit, Investigational
AmbrisentanThe serum concentration of Ambrisentan can be decreased when it is combined with Mitotane.Approved, Investigational
AmbroxolThe serum concentration of Ambroxol can be decreased when it is combined with Mitotane.Approved
AmcinonideThe serum concentration of Amcinonide can be decreased when it is combined with Mitotane.Approved
AminophenazoneThe serum concentration of Aminophenazone can be decreased when it is combined with Mitotane.Approved, Withdrawn
AminophyllineThe serum concentration of Aminophylline can be decreased when it is combined with Mitotane.Approved
AmiodaroneThe serum concentration of Amiodarone can be decreased when it is combined with Mitotane.Approved, Investigational
AmitriptylineThe serum concentration of Amitriptyline can be decreased when it is combined with Mitotane.Approved
AmlodipineThe serum concentration of Amlodipine can be decreased when it is combined with Mitotane.Approved
AmprenavirThe serum concentration of Amprenavir can be decreased when it is combined with Mitotane.Approved
AnecortaveThe serum concentration of Anecortave can be decreased when it is combined with Mitotane.Investigational
AntipyrineThe serum concentration of Antipyrine can be decreased when it is combined with Mitotane.Approved
AnvirzelAnvirzel may decrease the cardiotoxic activities of Mitotane.Investigational
ApixabanThe serum concentration of Apixaban can be decreased when it is combined with Mitotane.Approved
ApremilastThe serum concentration of Apremilast can be decreased when it is combined with Mitotane.Approved, Investigational
AprepitantThe serum concentration of Aprepitant can be decreased when it is combined with Mitotane.Approved, Investigational
ArgatrobanThe serum concentration of Argatroban can be decreased when it is combined with Mitotane.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Mitotane.Approved, Investigational
ArtemetherThe serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with Mitotane resulting in a loss in efficacy.Approved
AsenapineThe serum concentration of Asenapine can be decreased when it is combined with Mitotane.Approved
AstemizoleThe serum concentration of Astemizole can be decreased when it is combined with Mitotane.Approved, Withdrawn
AtazanavirThe serum concentration of Atazanavir can be decreased when it is combined with Mitotane.Approved, Investigational
AtorvastatinThe serum concentration of Atorvastatin can be decreased when it is combined with Mitotane.Approved
AvanafilThe serum concentration of Avanafil can be decreased when it is combined with Mitotane.Approved
AxitinibThe serum concentration of Axitinib can be decreased when it is combined with Mitotane.Approved, Investigational
AzelastineThe serum concentration of Azelastine can be decreased when it is combined with Mitotane.Approved
AzithromycinThe serum concentration of Azithromycin can be decreased when it is combined with Mitotane.Approved
BanoxantroneThe serum concentration of Banoxantrone can be decreased when it is combined with Mitotane.Investigational
BeclomethasoneThe serum concentration of Beclomethasone can be decreased when it is combined with Mitotane.Investigational
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be decreased when it is combined with Mitotane.Approved, Investigational
BedaquilineThe serum concentration of Bedaquiline can be decreased when it is combined with Mitotane.Approved
BenzphetamineThe serum concentration of Benzphetamine can be decreased when it is combined with Mitotane.Approved, Illicit
Benzyl alcoholThe serum concentration of Benzyl alcohol can be decreased when it is combined with Mitotane.Approved
BetamethasoneThe serum concentration of Betamethasone can be decreased when it is combined with Mitotane.Approved, Vet Approved
BevacizumabBevacizumab may increase the cardiotoxic activities of Mitotane.Approved, Investigational
BexaroteneThe serum concentration of Bexarotene can be decreased when it is combined with Mitotane.Approved, Investigational
BezafibrateThe serum concentration of Bezafibrate can be decreased when it is combined with Mitotane.Approved
BicalutamideThe serum concentration of Bicalutamide can be decreased when it is combined with Mitotane.Approved
BisoprololThe serum concentration of Bisoprolol can be decreased when it is combined with Mitotane.Approved
BoceprevirThe serum concentration of Boceprevir can be decreased when it is combined with Mitotane.Approved
BortezomibThe serum concentration of Bortezomib can be decreased when it is combined with Mitotane.Approved, Investigational
BosentanThe serum concentration of Bosentan can be decreased when it is combined with Mitotane.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be decreased when it is combined with Mitotane.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be decreased when it is combined with Mitotane.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be decreased when it is combined with Mitotane.Approved
BrinzolamideThe serum concentration of Brinzolamide can be decreased when it is combined with Mitotane.Approved
BromazepamThe serum concentration of Bromazepam can be decreased when it is combined with Mitotane.Approved, Illicit
BromocriptineThe serum concentration of Bromocriptine can be decreased when it is combined with Mitotane.Approved, Investigational
BrompheniramineThe serum concentration of Brompheniramine can be decreased when it is combined with Mitotane.Approved
BudesonideThe serum concentration of Budesonide can be decreased when it is combined with Mitotane.Approved
BupivacaineThe serum concentration of Bupivacaine can be decreased when it is combined with Mitotane.Approved, Investigational
BuprenorphineThe serum concentration of Buprenorphine can be decreased when it is combined with Mitotane.Approved, Illicit, Investigational, Vet Approved
BupropionThe serum concentration of Bupropion can be decreased when it is combined with Mitotane.Approved
BuspironeThe serum concentration of Buspirone can be decreased when it is combined with Mitotane.Approved, Investigational
BusulfanThe serum concentration of Busulfan can be decreased when it is combined with Mitotane.Approved, Investigational
CabazitaxelThe serum concentration of Cabazitaxel can be decreased when it is combined with Mitotane.Approved
CabergolineThe serum concentration of Cabergoline can be decreased when it is combined with Mitotane.Approved
CabozantinibThe serum concentration of Cabozantinib can be decreased when it is combined with Mitotane.Approved
CaffeineThe serum concentration of Caffeine can be decreased when it is combined with Mitotane.Approved
CalcitriolThe serum concentration of Calcitriol can be decreased when it is combined with Mitotane.Approved, Nutraceutical
CanagliflozinThe serum concentration of Canagliflozin can be decreased when it is combined with Mitotane.Approved
CannabidiolThe serum concentration of Cannabidiol can be decreased when it is combined with Mitotane.Approved, Investigational
CarbamazepineThe serum concentration of Carbamazepine can be decreased when it is combined with Mitotane.Approved, Investigational
CarbinoxamineThe serum concentration of Carbinoxamine can be decreased when it is combined with Mitotane.Approved
CariprazineThe serum concentration of Cariprazine can be decreased when it is combined with Mitotane.Approved
CarvedilolThe serum concentration of Carvedilol can be decreased when it is combined with Mitotane.Approved, Investigational
CelecoxibThe serum concentration of Celecoxib can be decreased when it is combined with Mitotane.Approved, Investigational
CeliprololThe serum concentration of Celiprolol can be decreased when it is combined with Mitotane.Approved, Investigational
CephalexinThe serum concentration of Cephalexin can be decreased when it is combined with Mitotane.Approved, Vet Approved
CeritinibThe serum concentration of Ceritinib can be decreased when it is combined with Mitotane.Approved
CerivastatinThe serum concentration of Cerivastatin can be decreased when it is combined with Mitotane.Withdrawn
CevimelineThe serum concentration of Cevimeline can be decreased when it is combined with Mitotane.Approved
Chenodeoxycholic acidThe serum concentration of Chenodeoxycholic acid can be decreased when it is combined with Mitotane.Approved
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Mitotane.Approved, Illicit
ChloroquineThe serum concentration of Chloroquine can be decreased when it is combined with Mitotane.Approved, Vet Approved
ChlorphenamineThe serum concentration of Chlorphenamine can be decreased when it is combined with Mitotane.Approved
ChlorpromazineThe serum concentration of Chlorpromazine can be decreased when it is combined with Mitotane.Approved, Vet Approved
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be decreased when it is combined with Mitotane.Approved
CholecalciferolThe serum concentration of Cholecalciferol can be decreased when it is combined with Mitotane.Approved, Nutraceutical
CiclesonideThe serum concentration of Ciclesonide can be decreased when it is combined with Mitotane.Approved, Investigational
CilostazolThe serum concentration of Cilostazol can be decreased when it is combined with Mitotane.Approved
CinacalcetThe serum concentration of Cinacalcet can be decreased when it is combined with Mitotane.Approved
CisaprideThe serum concentration of Cisapride can be decreased when it is combined with Mitotane.Approved, Investigational, Withdrawn
CitalopramThe serum concentration of Citalopram can be decreased when it is combined with Mitotane.Approved
ClarithromycinThe serum concentration of Clarithromycin can be decreased when it is combined with Mitotane.Approved
ClindamycinThe serum concentration of Clindamycin can be decreased when it is combined with Mitotane.Approved, Vet Approved
ClobazamThe serum concentration of Clobazam can be decreased when it is combined with Mitotane.Approved, Illicit
ClobetasolThe serum concentration of Clobetasol can be decreased when it is combined with Mitotane.Investigational
Clobetasol propionateThe serum concentration of Clobetasol propionate can be decreased when it is combined with Mitotane.Approved
ClocortoloneThe serum concentration of Clocortolone can be decreased when it is combined with Mitotane.Approved
ClofazimineThe serum concentration of Clofazimine can be decreased when it is combined with Mitotane.Approved, Investigational
ClofibrateThe serum concentration of Clofibrate can be decreased when it is combined with Mitotane.Approved
clomethiazoleThe serum concentration of clomethiazole can be decreased when it is combined with Mitotane.Investigational
ClomipramineThe serum concentration of Clomipramine can be decreased when it is combined with Mitotane.Approved, Vet Approved
ClonazepamThe serum concentration of Clonazepam can be decreased when it is combined with Mitotane.Approved, Illicit
ClonidineThe serum concentration of Clonidine can be decreased when it is combined with Mitotane.Approved
ClopidogrelThe serum concentration of Clopidogrel can be decreased when it is combined with Mitotane.Approved, Nutraceutical
ClorazepateThe serum concentration of Clorazepate can be decreased when it is combined with Mitotane.Approved, Illicit
ClotiazepamThe serum concentration of Clotiazepam can be decreased when it is combined with Mitotane.Approved, Illicit
ClozapineThe serum concentration of Clozapine can be decreased when it is combined with Mitotane.Approved
CobimetinibThe serum concentration of Cobimetinib can be decreased when it is combined with Mitotane.Approved
CocaineThe serum concentration of Cocaine can be decreased when it is combined with Mitotane.Approved, Illicit
CodeineThe serum concentration of Codeine can be decreased when it is combined with Mitotane.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be decreased when it is combined with Mitotane.Approved
ConivaptanThe serum concentration of Conivaptan can be decreased when it is combined with Mitotane.Approved, Investigational
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be decreased when it is combined with Mitotane.Approved
Cortisone acetateThe serum concentration of Cortisone acetate can be decreased when it is combined with Mitotane.Approved
CrizotinibThe serum concentration of Crizotinib can be decreased when it is combined with Mitotane.Approved
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be decreased when it is combined with Mitotane.Approved
CyclophosphamideThe serum concentration of Cyclophosphamide can be decreased when it is combined with Mitotane.Approved, Investigational
CyclosporineThe serum concentration of Cyclosporine can be decreased when it is combined with Mitotane.Approved, Investigational, Vet Approved
CytarabineThe serum concentration of Cytarabine can be decreased when it is combined with Mitotane.Approved, Investigational
DabrafenibThe serum concentration of Dabrafenib can be decreased when it is combined with Mitotane.Approved
DaclatasvirThe serum concentration of Daclatasvir can be decreased when it is combined with Mitotane.Approved
DantroleneThe serum concentration of Dantrolene can be decreased when it is combined with Mitotane.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be decreased when it is combined with Mitotane.Approved
DapsoneThe serum concentration of Dapsone can be decreased when it is combined with Mitotane.Approved, Investigational
DarifenacinThe serum concentration of Darifenacin can be decreased when it is combined with Mitotane.Approved, Investigational
DarunavirThe serum concentration of Darunavir can be decreased when it is combined with Mitotane.Approved
DasabuvirThe serum concentration of Dasabuvir can be decreased when it is combined with Mitotane.Approved
DasatinibThe serum concentration of Dasatinib can be decreased when it is combined with Mitotane.Approved, Investigational
DaunorubicinThe serum concentration of Daunorubicin can be decreased when it is combined with Mitotane.Approved
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be decreased when it is combined with Mitotane.Investigational
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Mitotane.Approved
DeslanosideDeslanoside may decrease the cardiotoxic activities of Mitotane.Approved
DesoximetasoneThe serum concentration of Desoximetasone can be decreased when it is combined with Mitotane.Approved
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be decreased when it is combined with Mitotane.Approved
Desoxycorticosterone PivalateThe serum concentration of Desoxycorticosterone Pivalate can be decreased when it is combined with Mitotane.Experimental, Vet Approved
DesvenlafaxineThe serum concentration of Desvenlafaxine can be decreased when it is combined with Mitotane.Approved
DexamethasoneThe serum concentration of Dexamethasone can be decreased when it is combined with Mitotane.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be decreased when it is combined with Mitotane.Vet Approved
DextromethorphanThe serum concentration of Dextromethorphan can be decreased when it is combined with Mitotane.Approved
DextropropoxypheneThe serum concentration of Dextropropoxyphene can be decreased when it is combined with Mitotane.Approved, Illicit, Withdrawn
DiazepamThe serum concentration of Diazepam can be decreased when it is combined with Mitotane.Approved, Illicit, Vet Approved
DiclofenacThe serum concentration of Diclofenac can be decreased when it is combined with Mitotane.Approved, Vet Approved
DienogestThe serum concentration of Dienogest can be decreased when it is combined with Mitotane.Approved
DiflorasoneThe serum concentration of Diflorasone can be decreased when it is combined with Mitotane.Approved
DifluocortoloneThe serum concentration of Difluocortolone can be decreased when it is combined with Mitotane.Approved
DifluprednateThe serum concentration of Difluprednate can be decreased when it is combined with Mitotane.Approved
DigitoxinThe serum concentration of Digitoxin can be decreased when it is combined with Mitotane.Approved
DigoxinThe serum concentration of Digoxin can be decreased when it is combined with Mitotane.Approved
DihydrocodeineThe serum concentration of Dihydrocodeine can be decreased when it is combined with Mitotane.Approved, Illicit
DihydroergotamineThe serum concentration of Dihydroergotamine can be decreased when it is combined with Mitotane.Approved
DiltiazemThe serum concentration of Diltiazem can be decreased when it is combined with Mitotane.Approved
DisopyramideThe serum concentration of Disopyramide can be decreased when it is combined with Mitotane.Approved
DisulfiramThe serum concentration of Disulfiram can be decreased when it is combined with Mitotane.Approved
DocetaxelThe serum concentration of Docetaxel can be decreased when it is combined with Mitotane.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be decreased when it is combined with Mitotane.Approved
DolasetronThe serum concentration of Dolasetron can be decreased when it is combined with Mitotane.Approved
DomperidoneThe serum concentration of Domperidone can be decreased when it is combined with Mitotane.Approved, Investigational, Vet Approved
DonepezilThe serum concentration of Donepezil can be decreased when it is combined with Mitotane.Approved
DorzolamideThe serum concentration of Dorzolamide can be decreased when it is combined with Mitotane.Approved
DoxepinThe serum concentration of Doxepin can be decreased when it is combined with Mitotane.Approved
DoxorubicinThe serum concentration of Doxorubicin can be decreased when it is combined with Mitotane.Approved, Investigational
DronabinolThe serum concentration of Dronabinol can be decreased when it is combined with Mitotane.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be decreased when it is combined with Mitotane.Approved
DutasterideThe serum concentration of Dutasteride can be decreased when it is combined with Mitotane.Approved, Investigational
EfavirenzThe serum concentration of Efavirenz can be decreased when it is combined with Mitotane.Approved, Investigational
EletriptanThe serum concentration of Eletriptan can be decreased when it is combined with Mitotane.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be decreased when it is combined with Mitotane.Approved
ElvitegravirThe serum concentration of Elvitegravir can be decreased when it is combined with Mitotane.Approved
EnalaprilThe serum concentration of Enalapril can be decreased when it is combined with Mitotane.Approved, Vet Approved
EnzalutamideThe serum concentration of Enzalutamide can be decreased when it is combined with Mitotane.Approved
EpinastineThe serum concentration of Epinastine can be decreased when it is combined with Mitotane.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be decreased when it is combined with Mitotane.Approved
EquileninThe serum concentration of Equilenin can be decreased when it is combined with Mitotane.Experimental
EquilinThe serum concentration of Equilin can be decreased when it is combined with Mitotane.Approved
ErgocalciferolThe serum concentration of Ergocalciferol can be decreased when it is combined with Mitotane.Approved, Nutraceutical
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be decreased when it is combined with Mitotane.Approved
ErgonovineThe serum concentration of Ergonovine can be decreased when it is combined with Mitotane.Approved
ErgotamineThe serum concentration of Ergotamine can be decreased when it is combined with Mitotane.Approved
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with Mitotane.Approved, Investigational
ErythromycinThe serum concentration of Erythromycin can be decreased when it is combined with Mitotane.Approved, Vet Approved
EscitalopramThe serum concentration of Escitalopram can be decreased when it is combined with Mitotane.Approved, Investigational
EsomeprazoleThe serum concentration of Esomeprazole can be decreased when it is combined with Mitotane.Approved, Investigational
EstazolamThe serum concentration of Estazolam can be decreased when it is combined with Mitotane.Approved, Illicit
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Mitotane.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe serum concentration of Estradiol valerate/Dienogest can be decreased when it is combined with Mitotane.Approved
EstramustineThe serum concentration of Estramustine can be decreased when it is combined with Mitotane.Approved
EstroneThe serum concentration of Estrone can be decreased when it is combined with Mitotane.Approved
Estrone sulfateThe serum concentration of Estrone sulfate can be decreased when it is combined with Mitotane.Approved
EszopicloneThe serum concentration of Eszopiclone can be decreased when it is combined with Mitotane.Approved
EthanolThe serum concentration of Ethanol can be decreased when it is combined with Mitotane.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Mitotane.Approved
EthosuximideThe serum concentration of Ethosuximide can be decreased when it is combined with Mitotane.Approved
EthylmorphineThe serum concentration of Ethylmorphine can be decreased when it is combined with Mitotane.Approved, Illicit
EtonogestrelThe serum concentration of Etonogestrel can be decreased when it is combined with Mitotane.Approved, Investigational
EtoposideThe serum concentration of Etoposide can be decreased when it is combined with Mitotane.Approved
EtoricoxibThe serum concentration of Etoricoxib can be decreased when it is combined with Mitotane.Approved, Investigational
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Mitotane.Approved
EverolimusThe serum concentration of Everolimus can be decreased when it is combined with Mitotane.Approved
ExemestaneThe serum concentration of Exemestane can be decreased when it is combined with Mitotane.Approved, Investigational
FamciclovirThe serum concentration of Famciclovir can be decreased when it is combined with Mitotane.Approved
FelbamateThe serum concentration of Felbamate can be decreased when it is combined with Mitotane.Approved
FelodipineThe serum concentration of Felodipine can be decreased when it is combined with Mitotane.Approved, Investigational
FenofibrateThe serum concentration of Fenofibrate can be decreased when it is combined with Mitotane.Approved
FentanylThe serum concentration of Fentanyl can be decreased when it is combined with Mitotane.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of Fesoterodine can be decreased when it is combined with Mitotane.Approved
FinasterideThe serum concentration of Finasteride can be decreased when it is combined with Mitotane.Approved
FingolimodThe serum concentration of Fingolimod can be decreased when it is combined with Mitotane.Approved, Investigational
FlibanserinThe serum concentration of Flibanserin can be decreased when it is combined with Mitotane.Approved
fluasteroneThe serum concentration of fluasterone can be decreased when it is combined with Mitotane.Investigational
FludrocortisoneThe serum concentration of Fludrocortisone can be decreased when it is combined with Mitotane.Approved
FlumethasoneThe serum concentration of Flumethasone can be decreased when it is combined with Mitotane.Approved, Vet Approved
FlunisolideThe serum concentration of Flunisolide can be decreased when it is combined with Mitotane.Approved, Investigational
FlunitrazepamThe serum concentration of Flunitrazepam can be decreased when it is combined with Mitotane.Approved, Illicit
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be decreased when it is combined with Mitotane.Approved, Investigational, Vet Approved
FluocinonideThe serum concentration of Fluocinonide can be decreased when it is combined with Mitotane.Approved, Investigational
FluocortoloneThe serum concentration of Fluocortolone can be decreased when it is combined with Mitotane.Approved, Withdrawn
FluorometholoneThe serum concentration of Fluorometholone can be decreased when it is combined with Mitotane.Approved
FluoxetineThe serum concentration of Fluoxetine can be decreased when it is combined with Mitotane.Approved, Vet Approved
FluprednideneThe serum concentration of Fluprednidene can be decreased when it is combined with Mitotane.Approved, Withdrawn
FluprednisoloneThe serum concentration of Fluprednisolone can be decreased when it is combined with Mitotane.Approved
FlurandrenolideThe serum concentration of Flurandrenolide can be decreased when it is combined with Mitotane.Approved
FlurazepamThe serum concentration of Flurazepam can be decreased when it is combined with Mitotane.Approved, Illicit
FlutamideThe serum concentration of Flutamide can be decreased when it is combined with Mitotane.Approved
Fluticasone furoateThe serum concentration of Fluticasone furoate can be decreased when it is combined with Mitotane.Approved
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be decreased when it is combined with Mitotane.Approved
FluvastatinThe serum concentration of Fluvastatin can be decreased when it is combined with Mitotane.Approved
FormestaneThe serum concentration of Formestane can be decreased when it is combined with Mitotane.Approved, Investigational, Withdrawn
FosamprenavirThe serum concentration of Fosamprenavir can be decreased when it is combined with Mitotane.Approved
FulvestrantThe serum concentration of Fulvestrant can be decreased when it is combined with Mitotane.Approved, Investigational
GalantamineThe serum concentration of Galantamine can be decreased when it is combined with Mitotane.Approved
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with Mitotane.Approved, Investigational
GemfibrozilThe serum concentration of Gemfibrozil can be decreased when it is combined with Mitotane.Approved
GlipizideThe serum concentration of Glipizide can be decreased when it is combined with Mitotane.Approved
GlyburideThe serum concentration of Glyburide can be decreased when it is combined with Mitotane.Approved
GranisetronThe serum concentration of Granisetron can be decreased when it is combined with Mitotane.Approved, Investigational
GrepafloxacinThe serum concentration of Grepafloxacin can be decreased when it is combined with Mitotane.Withdrawn
GuanfacineThe serum concentration of Guanfacine can be decreased when it is combined with Mitotane.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be decreased when it is combined with Mitotane.Approved
HaloperidolThe serum concentration of Haloperidol can be decreased when it is combined with Mitotane.Approved
HalothaneThe serum concentration of Halothane can be decreased when it is combined with Mitotane.Approved, Vet Approved
HE3286The serum concentration of HE3286 can be decreased when it is combined with Mitotane.Investigational
HexobarbitalThe serum concentration of Hexobarbital can be decreased when it is combined with Mitotane.Approved
Histamine PhosphateThe serum concentration of Histamine Phosphate can be decreased when it is combined with Mitotane.Approved
HydrocodoneThe serum concentration of Hydrocodone can be decreased when it is combined with Mitotane.Approved, Illicit
HydrocortisoneThe serum concentration of Hydrocortisone can be decreased when it is combined with Mitotane.Approved, Vet Approved
HydromorphoneThe serum concentration of Hydromorphone can be decreased when it is combined with Mitotane.Approved, Illicit
Hydroxyprogesterone caproateThe serum concentration of Hydroxyprogesterone caproate can be decreased when it is combined with Mitotane.Approved
IbrutinibThe serum concentration of Ibrutinib can be decreased when it is combined with Mitotane.Approved
IdelalisibThe serum concentration of Idelalisib can be decreased when it is combined with Mitotane.Approved
IfosfamideThe serum concentration of Ifosfamide can be decreased when it is combined with Mitotane.Approved
IloperidoneThe serum concentration of Iloperidone can be decreased when it is combined with Mitotane.Approved
ImatinibThe serum concentration of Imatinib can be decreased when it is combined with Mitotane.Approved
ImipramineThe serum concentration of Imipramine can be decreased when it is combined with Mitotane.Approved
ImiquimodThe serum concentration of Imiquimod can be decreased when it is combined with Mitotane.Approved, Investigational
IndacaterolThe serum concentration of Indacaterol can be decreased when it is combined with Mitotane.Approved
IndapamideThe serum concentration of Indapamide can be decreased when it is combined with Mitotane.Approved
IndinavirThe serum concentration of Indinavir can be decreased when it is combined with Mitotane.Approved
Ipratropium bromideThe serum concentration of Ipratropium bromide can be decreased when it is combined with Mitotane.Approved
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be reduced when Irinotecan is used in combination with Mitotane resulting in a loss in efficacy.Approved, Investigational
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Mitotane resulting in a loss in efficacy.Approved, Investigational
Isosorbide DinitrateThe serum concentration of Isosorbide Dinitrate can be decreased when it is combined with Mitotane.Approved
Isosorbide MononitrateThe serum concentration of Isosorbide Mononitrate can be decreased when it is combined with Mitotane.Approved
IsradipineThe serum concentration of Isradipine can be decreased when it is combined with Mitotane.Approved
IstaroximeThe serum concentration of Istaroxime can be decreased when it is combined with Mitotane.Investigational
ItraconazoleThe serum concentration of Itraconazole can be decreased when it is combined with Mitotane.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be decreased when it is combined with Mitotane.Approved
IvacaftorThe serum concentration of Ivacaftor can be decreased when it is combined with Mitotane.Approved
IvermectinThe serum concentration of Ivermectin can be decreased when it is combined with Mitotane.Approved, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be decreased when it is combined with Mitotane.Approved, Investigational
IxazomibThe serum concentration of Ixazomib can be decreased when it is combined with Mitotane.Approved
KetamineThe serum concentration of Ketamine can be decreased when it is combined with Mitotane.Approved, Vet Approved
KetazolamThe serum concentration of Ketazolam can be decreased when it is combined with Mitotane.Approved
KetobemidoneThe serum concentration of Ketobemidone can be decreased when it is combined with Mitotane.Approved
KetoconazoleThe serum concentration of Ketoconazole can be decreased when it is combined with Mitotane.Approved, Investigational
LansoprazoleThe serum concentration of Lansoprazole can be decreased when it is combined with Mitotane.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be decreased when it is combined with Mitotane.Approved, Investigational
LaquinimodThe serum concentration of Laquinimod can be decreased when it is combined with Mitotane.Investigational
LenvatinibThe serum concentration of Lenvatinib can be decreased when it is combined with Mitotane.Approved
LercanidipineThe serum concentration of Lercanidipine can be decreased when it is combined with Mitotane.Approved, Investigational
LetrozoleThe serum concentration of Letrozole can be decreased when it is combined with Mitotane.Approved, Investigational
LevobupivacaineThe serum concentration of Levobupivacaine can be decreased when it is combined with Mitotane.Approved
LevocetirizineThe serum concentration of Levocetirizine can be decreased when it is combined with Mitotane.Approved
Levomethadyl AcetateThe serum concentration of Levomethadyl Acetate can be decreased when it is combined with Mitotane.Approved
LevomilnacipranThe serum concentration of Levomilnacipran can be decreased when it is combined with Mitotane.Approved
LevonorgestrelThe serum concentration of Levonorgestrel can be decreased when it is combined with Mitotane.Approved, Investigational
LevothyroxineThe serum concentration of Levothyroxine can be decreased when it is combined with Mitotane.Approved
LidocaineThe serum concentration of Lidocaine can be decreased when it is combined with Mitotane.Approved, Vet Approved
LinagliptinThe serum concentration of Linagliptin can be decreased when it is combined with Mitotane.Approved
LisurideThe serum concentration of Lisuride can be decreased when it is combined with Mitotane.Approved
LomitapideThe serum concentration of Lomitapide can be decreased when it is combined with Mitotane.Approved
LoperamideThe serum concentration of Loperamide can be decreased when it is combined with Mitotane.Approved
LopinavirThe serum concentration of Lopinavir can be decreased when it is combined with Mitotane.Approved
LoratadineThe serum concentration of Loratadine can be decreased when it is combined with Mitotane.Approved
LorcaserinThe serum concentration of Lorcaserin can be decreased when it is combined with Mitotane.Approved
LosartanThe serum concentration of Losartan can be decreased when it is combined with Mitotane.Approved
LovastatinThe serum concentration of Lovastatin can be decreased when it is combined with Mitotane.Approved, Investigational
LumefantrineThe serum concentration of Lumefantrine can be decreased when it is combined with Mitotane.Approved
LurasidoneThe serum concentration of Lurasidone can be decreased when it is combined with Mitotane.Approved
MacitentanThe serum concentration of Macitentan can be decreased when it is combined with Mitotane.Approved
MaravirocThe serum concentration of Maraviroc can be decreased when it is combined with Mitotane.Approved, Investigational
ME-609The serum concentration of ME-609 can be decreased when it is combined with Mitotane.Investigational
MebendazoleThe serum concentration of Mebendazole can be decreased when it is combined with Mitotane.Approved, Vet Approved
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Mitotane.Approved, Investigational
MedrysoneThe serum concentration of Medrysone can be decreased when it is combined with Mitotane.Approved
MefloquineThe serum concentration of Mefloquine can be decreased when it is combined with Mitotane.Approved
MelengestrolThe serum concentration of Melengestrol can be decreased when it is combined with Mitotane.Vet Approved
MeloxicamThe serum concentration of Meloxicam can be decreased when it is combined with Mitotane.Approved, Vet Approved
MethadoneThe serum concentration of Methadone can be decreased when it is combined with Mitotane.Approved
MethaqualoneThe serum concentration of Methaqualone can be decreased when it is combined with Mitotane.Illicit, Withdrawn
MethoxsalenThe serum concentration of Methoxsalen can be decreased when it is combined with Mitotane.Approved
MethoxyfluraneThe serum concentration of Methoxyflurane can be decreased when it is combined with Mitotane.Approved, Vet Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be decreased when it is combined with Mitotane.Approved, Vet Approved
MethyltestosteroneThe serum concentration of Methyltestosterone can be decreased when it is combined with Mitotane.Approved
MetronidazoleThe serum concentration of Metronidazole can be decreased when it is combined with Mitotane.Approved
MexiletineThe serum concentration of Mexiletine can be decreased when it is combined with Mitotane.Approved
MianserinThe serum concentration of Mianserin can be decreased when it is combined with Mitotane.Approved
MibefradilThe serum concentration of Mibefradil can be decreased when it is combined with Mitotane.Withdrawn
MiconazoleThe serum concentration of Miconazole can be decreased when it is combined with Mitotane.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Midazolam can be decreased when it is combined with Mitotane.Approved, Illicit
MifepristoneThe serum concentration of Mifepristone can be decreased when it is combined with Mitotane.Approved, Investigational
MirabegronThe serum concentration of Mirabegron can be decreased when it is combined with Mitotane.Approved
MirtazapineThe serum concentration of Mirtazapine can be decreased when it is combined with Mitotane.Approved
ModafinilThe serum concentration of Modafinil can be decreased when it is combined with Mitotane.Approved, Investigational
MometasoneThe serum concentration of Mometasone can be decreased when it is combined with Mitotane.Approved, Vet Approved
MontelukastThe serum concentration of Montelukast can be decreased when it is combined with Mitotane.Approved
MorphineThe serum concentration of Morphine can be decreased when it is combined with Mitotane.Approved, Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be decreased when it is combined with Mitotane.Approved, Investigational
NaloxegolThe serum concentration of Naloxegol can be decreased when it is combined with Mitotane.Approved
NaloxoneThe serum concentration of Naloxone can be decreased when it is combined with Mitotane.Approved, Vet Approved
NateglinideThe serum concentration of Nateglinide can be decreased when it is combined with Mitotane.Approved, Investigational
NCX 1022The serum concentration of NCX 1022 can be decreased when it is combined with Mitotane.Investigational
NefazodoneThe serum concentration of Nefazodone can be decreased when it is combined with Mitotane.Approved, Withdrawn
NelfinavirThe serum concentration of Nelfinavir can be decreased when it is combined with Mitotane.Approved
NetupitantThe serum concentration of Netupitant can be decreased when it is combined with Mitotane.Approved
NevirapineThe serum concentration of Nevirapine can be decreased when it is combined with Mitotane.Approved
NicardipineThe serum concentration of Nicardipine can be decreased when it is combined with Mitotane.Approved
NicotineThe serum concentration of Nicotine can be decreased when it is combined with Mitotane.Approved
NifedipineThe serum concentration of Nifedipine can be decreased when it is combined with Mitotane.Approved
NilotinibThe serum concentration of Nilotinib can be decreased when it is combined with Mitotane.Approved, Investigational
NilvadipineThe serum concentration of Nilvadipine can be decreased when it is combined with Mitotane.Approved
NimodipineThe serum concentration of Nimodipine can be decreased when it is combined with Mitotane.Approved
NisoldipineThe serum concentration of Nisoldipine can be decreased when it is combined with Mitotane.Approved
NitrazepamThe serum concentration of Nitrazepam can be decreased when it is combined with Mitotane.Approved
NitrendipineThe serum concentration of Nitrendipine can be decreased when it is combined with Mitotane.Approved
NorethisteroneThe serum concentration of Norethisterone can be decreased when it is combined with Mitotane.Approved
NorgestrelThe serum concentration of Norgestrel can be decreased when it is combined with Mitotane.Approved
NortriptylineThe serum concentration of Nortriptyline can be decreased when it is combined with Mitotane.Approved
OlaparibThe serum concentration of Olaparib can be decreased when it is combined with Mitotane.Approved
Oleoyl estroneThe serum concentration of Oleoyl estrone can be decreased when it is combined with Mitotane.Investigational
OlopatadineThe serum concentration of Olopatadine can be decreased when it is combined with Mitotane.Approved
OmeprazoleThe serum concentration of Omeprazole can be decreased when it is combined with Mitotane.Approved, Investigational, Vet Approved
OndansetronThe serum concentration of Ondansetron can be decreased when it is combined with Mitotane.Approved
OrphenadrineThe serum concentration of Orphenadrine can be decreased when it is combined with Mitotane.Approved
OsimertinibThe serum concentration of Osimertinib can be decreased when it is combined with Mitotane.Approved
OspemifeneThe serum concentration of Ospemifene can be decreased when it is combined with Mitotane.Approved
OuabainOuabain may decrease the cardiotoxic activities of Mitotane.Approved
OxazepamThe serum concentration of Oxazepam can be decreased when it is combined with Mitotane.Approved
OxybutyninThe serum concentration of Oxybutynin can be decreased when it is combined with Mitotane.Approved, Investigational
OxycodoneThe serum concentration of Oxycodone can be decreased when it is combined with Mitotane.Approved, Illicit, Investigational
OxymorphoneThe serum concentration of Oxymorphone can be decreased when it is combined with Mitotane.Approved, Investigational, Vet Approved
PaclitaxelThe serum concentration of Paclitaxel can be decreased when it is combined with Mitotane.Approved, Vet Approved
PalbociclibThe serum concentration of Palbociclib can be decreased when it is combined with Mitotane.Approved
PalonosetronThe serum concentration of Palonosetron can be decreased when it is combined with Mitotane.Approved, Investigational
PanobinostatThe serum concentration of Panobinostat can be decreased when it is combined with Mitotane.Approved, Investigational
PantoprazoleThe serum concentration of Pantoprazole can be decreased when it is combined with Mitotane.Approved
ParamethadioneThe serum concentration of Paramethadione can be decreased when it is combined with Mitotane.Approved
ParamethasoneThe serum concentration of Paramethasone can be decreased when it is combined with Mitotane.Approved
ParecoxibThe serum concentration of Parecoxib can be decreased when it is combined with Mitotane.Approved
ParicalcitolThe serum concentration of Paricalcitol can be decreased when it is combined with Mitotane.Approved, Investigational
ParitaprevirThe serum concentration of Paritaprevir can be decreased when it is combined with Mitotane.Approved
PazopanibThe serum concentration of Pazopanib can be decreased when it is combined with Mitotane.Approved
PentamidineThe serum concentration of Pentamidine can be decreased when it is combined with Mitotane.Approved
PerampanelThe serum concentration of Perampanel can be decreased when it is combined with Mitotane.Approved
PergolideThe serum concentration of Pergolide can be decreased when it is combined with Mitotane.Approved, Vet Approved, Withdrawn
PerhexilineThe serum concentration of Perhexiline can be decreased when it is combined with Mitotane.Approved
PermethrinThe serum concentration of Permethrin can be decreased when it is combined with Mitotane.Approved, Investigational
PerphenazineThe serum concentration of Perphenazine can be decreased when it is combined with Mitotane.Approved
PethidineThe serum concentration of Pethidine can be decreased when it is combined with Mitotane.Approved
PhenacetinThe serum concentration of Phenacetin can be decreased when it is combined with Mitotane.Withdrawn
PhenoxybenzamineThe serum concentration of Phenoxybenzamine can be decreased when it is combined with Mitotane.Approved
PhenprocoumonThe serum concentration of Phenprocoumon can be decreased when it is combined with Mitotane.Approved
PhenytoinThe serum concentration of Phenytoin can be decreased when it is combined with Mitotane.Approved, Vet Approved
PilocarpineThe serum concentration of Pilocarpine can be decreased when it is combined with Mitotane.Approved
PimecrolimusThe serum concentration of Pimecrolimus can be decreased when it is combined with Mitotane.Approved, Investigational
PimozideThe serum concentration of Pimozide can be decreased when it is combined with Mitotane.Approved
PinacidilThe serum concentration of Pinacidil can be decreased when it is combined with Mitotane.Withdrawn
PioglitazoneThe serum concentration of Pioglitazone can be decreased when it is combined with Mitotane.Approved, Investigational
PipotiazineThe serum concentration of Pipotiazine can be decreased when it is combined with Mitotane.Approved
PodofiloxThe serum concentration of Podofilox can be decreased when it is combined with Mitotane.Approved
PomalidomideThe serum concentration of Pomalidomide can be decreased when it is combined with Mitotane.Approved
PonatinibThe serum concentration of Ponatinib can be decreased when it is combined with Mitotane.Approved
PosaconazoleThe serum concentration of Posaconazole can be decreased when it is combined with Mitotane.Approved, Investigational, Vet Approved
PrasteroneThe serum concentration of Prasterone can be decreased when it is combined with Mitotane.Approved, Nutraceutical
PrasugrelThe serum concentration of Prasugrel can be decreased when it is combined with Mitotane.Approved
PravastatinThe serum concentration of Pravastatin can be decreased when it is combined with Mitotane.Approved
PrazepamThe serum concentration of Prazepam can be decreased when it is combined with Mitotane.Approved, Illicit
PraziquantelThe serum concentration of Praziquantel can be decreased when it is combined with Mitotane.Approved, Vet Approved
PrednicarbateThe serum concentration of Prednicarbate can be decreased when it is combined with Mitotane.Approved
PrednisoloneThe serum concentration of Prednisolone can be decreased when it is combined with Mitotane.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be decreased when it is combined with Mitotane.Approved, Vet Approved
PregnenoloneThe serum concentration of Pregnenolone can be decreased when it is combined with Mitotane.Experimental
PrimaquineThe serum concentration of Primaquine can be decreased when it is combined with Mitotane.Approved
ProchlorperazineThe serum concentration of Prochlorperazine can be decreased when it is combined with Mitotane.Approved, Vet Approved
ProgesteroneThe serum concentration of Progesterone can be decreased when it is combined with Mitotane.Approved, Vet Approved
ProguanilThe serum concentration of Proguanil can be decreased when it is combined with Mitotane.Approved
PromazineThe serum concentration of Promazine can be decreased when it is combined with Mitotane.Approved, Vet Approved
PropafenoneThe serum concentration of Propafenone can be decreased when it is combined with Mitotane.Approved
PropofolThe serum concentration of Propofol can be decreased when it is combined with Mitotane.Approved, Investigational, Vet Approved
PropranololThe serum concentration of Propranolol can be decreased when it is combined with Mitotane.Approved, Investigational
PyrazinamideThe serum concentration of Pyrazinamide can be decreased when it is combined with Mitotane.Approved
QuazepamThe serum concentration of Quazepam can be decreased when it is combined with Mitotane.Approved, Illicit
QuetiapineThe serum concentration of Quetiapine can be decreased when it is combined with Mitotane.Approved
QuinacrineThe serum concentration of Quinacrine can be decreased when it is combined with Mitotane.Approved
QuinidineThe serum concentration of Quinidine can be decreased when it is combined with Mitotane.Approved
QuinineThe serum concentration of Quinine can be decreased when it is combined with Mitotane.Approved
RabeprazoleThe serum concentration of Rabeprazole can be decreased when it is combined with Mitotane.Approved, Investigational
RaloxifeneThe serum concentration of Raloxifene can be decreased when it is combined with Mitotane.Approved, Investigational
RamelteonThe serum concentration of Ramelteon can be decreased when it is combined with Mitotane.Approved, Investigational
RanolazineThe serum concentration of Ranolazine can be decreased when it is combined with Mitotane.Approved, Investigational
ReboxetineThe serum concentration of Reboxetine can be decreased when it is combined with Mitotane.Approved, Investigational
RegorafenibThe serum concentration of Regorafenib can be decreased when it is combined with Mitotane.Approved
RepaglinideThe serum concentration of Repaglinide can be decreased when it is combined with Mitotane.Approved, Investigational
RetapamulinThe serum concentration of Retapamulin can be decreased when it is combined with Mitotane.Approved
RifabutinThe serum concentration of Rifabutin can be decreased when it is combined with Mitotane.Approved
RifampicinThe serum concentration of Rifampicin can be decreased when it is combined with Mitotane.Approved
RilpivirineThe serum concentration of Rilpivirine can be decreased when it is combined with Mitotane.Approved
RimexoloneThe serum concentration of Rimexolone can be decreased when it is combined with Mitotane.Approved
RimonabantThe serum concentration of Rimonabant can be decreased when it is combined with Mitotane.Approved, Investigational
RiociguatThe serum concentration of Riociguat can be decreased when it is combined with Mitotane.Approved
RisperidoneThe serum concentration of Risperidone can be decreased when it is combined with Mitotane.Approved, Investigational
RitonavirThe serum concentration of Ritonavir can be decreased when it is combined with Mitotane.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be decreased when it is combined with Mitotane.Approved
RofecoxibThe serum concentration of Rofecoxib can be decreased when it is combined with Mitotane.Investigational, Withdrawn
RoflumilastThe serum concentration of Roflumilast can be decreased when it is combined with Mitotane.Approved
RolapitantThe serum concentration of Rolapitant can be decreased when it is combined with Mitotane.Approved
RomidepsinThe serum concentration of Romidepsin can be decreased when it is combined with Mitotane.Approved, Investigational
RopiniroleThe serum concentration of Ropinirole can be decreased when it is combined with Mitotane.Approved, Investigational
RopivacaineThe serum concentration of Ropivacaine can be decreased when it is combined with Mitotane.Approved
RosuvastatinThe serum concentration of Rosuvastatin can be decreased when it is combined with Mitotane.Approved
RotigotineThe serum concentration of Rotigotine can be decreased when it is combined with Mitotane.Approved
RoxithromycinThe serum concentration of Roxithromycin can be decreased when it is combined with Mitotane.Approved, Withdrawn
RuxolitinibThe serum concentration of Ruxolitinib can be decreased when it is combined with Mitotane.Approved
SalmeterolThe serum concentration of Salmeterol can be decreased when it is combined with Mitotane.Approved
SaquinavirThe serum concentration of Saquinavir can be decreased when it is combined with Mitotane.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Mitotane.Approved
SelegilineThe serum concentration of Selegiline can be decreased when it is combined with Mitotane.Approved, Investigational, Vet Approved
SelexipagThe serum concentration of Selexipag can be decreased when it is combined with Mitotane.Approved
SeratrodastThe serum concentration of Seratrodast can be decreased when it is combined with Mitotane.Approved, Investigational
SertindoleThe serum concentration of Sertindole can be decreased when it is combined with Mitotane.Approved, Withdrawn
SertralineThe serum concentration of Sertraline can be decreased when it is combined with Mitotane.Approved
SevofluraneThe serum concentration of Sevoflurane can be decreased when it is combined with Mitotane.Approved, Vet Approved
SibutramineThe serum concentration of Sibutramine can be decreased when it is combined with Mitotane.Approved, Illicit, Investigational, Withdrawn
SildenafilThe serum concentration of Sildenafil can be decreased when it is combined with Mitotane.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be decreased when it is combined with Mitotane.Approved
SimeprevirThe serum concentration of Simeprevir can be decreased when it is combined with Mitotane.Approved
SimvastatinThe serum concentration of Simvastatin can be decreased when it is combined with Mitotane.Approved
SirolimusThe serum concentration of Sirolimus can be decreased when it is combined with Mitotane.Approved, Investigational
SitagliptinThe serum concentration of Sitagliptin can be decreased when it is combined with Mitotane.Approved, Investigational
SolifenacinThe serum concentration of Solifenacin can be decreased when it is combined with Mitotane.Approved
SonidegibThe serum concentration of Sonidegib can be decreased when it is combined with Mitotane.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be decreased when it is combined with Mitotane.Approved, Investigational
SpiramycinThe serum concentration of Spiramycin can be decreased when it is combined with Mitotane.Approved
SpironolactoneThe therapeutic efficacy of Mitotane can be decreased when used in combination with Spironolactone.Approved
SufentanilThe serum concentration of Sufentanil can be decreased when it is combined with Mitotane.Approved, Investigational
SulfadiazineThe serum concentration of Sulfadiazine can be decreased when it is combined with Mitotane.Approved, Vet Approved
SulfamethoxazoleThe serum concentration of Sulfamethoxazole can be decreased when it is combined with Mitotane.Approved
SulfinpyrazoneThe serum concentration of Sulfinpyrazone can be decreased when it is combined with Mitotane.Approved
SunitinibThe serum concentration of Sunitinib can be decreased when it is combined with Mitotane.Approved, Investigational
SuvorexantThe serum concentration of Suvorexant can be decreased when it is combined with Mitotane.Approved
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be decreased when it is combined with Mitotane.Approved
Synthetic Conjugated Estrogens, BThe serum concentration of Synthetic Conjugated Estrogens, B can be decreased when it is combined with Mitotane.Approved
TacrolimusThe serum concentration of Tacrolimus can be decreased when it is combined with Mitotane.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be decreased when it is combined with Mitotane.Approved, Investigational
TamoxifenThe serum concentration of Tamoxifen can be decreased when it is combined with Mitotane.Approved
TamsulosinThe serum concentration of Tamsulosin can be decreased when it is combined with Mitotane.Approved, Investigational
TasimelteonThe serum concentration of Tasimelteon can be decreased when it is combined with Mitotane.Approved
TasosartanThe serum concentration of Tasosartan can be decreased when it is combined with Mitotane.Approved
Taurochenodeoxycholic acidThe serum concentration of Taurochenodeoxycholic acid can be decreased when it is combined with Mitotane.Experimental
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Mitotane.Approved
TelithromycinThe serum concentration of Telithromycin can be decreased when it is combined with Mitotane.Approved
TemazepamThe serum concentration of Temazepam can be decreased when it is combined with Mitotane.Approved
TemsirolimusThe serum concentration of Temsirolimus can be decreased when it is combined with Mitotane.Approved
TeniposideThe serum concentration of Teniposide can be decreased when it is combined with Mitotane.Approved
TerbinafineThe serum concentration of Terbinafine can be decreased when it is combined with Mitotane.Approved, Investigational, Vet Approved
TerfenadineThe serum concentration of Terfenadine can be decreased when it is combined with Mitotane.Withdrawn
TesmilifeneThe serum concentration of Tesmilifene can be decreased when it is combined with Mitotane.Investigational
TestosteroneThe serum concentration of Testosterone can be decreased when it is combined with Mitotane.Approved, Investigational
TetracyclineThe serum concentration of Tetracycline can be decreased when it is combined with Mitotane.Approved, Vet Approved
TheophyllineThe serum concentration of Theophylline can be decreased when it is combined with Mitotane.Approved
ThiotepaThe serum concentration of Thiotepa can be decreased when it is combined with Mitotane.Approved
TiagabineThe serum concentration of Tiagabine can be decreased when it is combined with Mitotane.Approved
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Mitotane resulting in a loss in efficacy.Approved
TiclopidineThe serum concentration of Ticlopidine can be decreased when it is combined with Mitotane.Approved
TinidazoleThe serum concentration of Tinidazole can be decreased when it is combined with Mitotane.Approved, Investigational
TiotropiumThe serum concentration of Tiotropium can be decreased when it is combined with Mitotane.Approved
TipranavirThe serum concentration of Tipranavir can be decreased when it is combined with Mitotane.Approved, Investigational
TixocortolThe serum concentration of Tixocortol can be decreased when it is combined with Mitotane.Approved
TofacitinibThe serum concentration of Tofacitinib can be decreased when it is combined with Mitotane.Approved, Investigational
TolterodineThe serum concentration of Tolterodine can be decreased when it is combined with Mitotane.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be decreased when it is combined with Mitotane.Approved
ToremifeneThe serum concentration of Toremifene can be decreased when it is combined with Mitotane.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be decreased when it is combined with Mitotane.Approved, Investigational
TramadolThe serum concentration of Tramadol can be decreased when it is combined with Mitotane.Approved, Investigational
TrastuzumabTrastuzumab may increase the cardiotoxic activities of Mitotane.Approved, Investigational
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be decreased when it is combined with Mitotane.Approved
TrazodoneThe serum concentration of Trazodone can be decreased when it is combined with Mitotane.Approved, Investigational
TretinoinThe serum concentration of Tretinoin can be decreased when it is combined with Mitotane.Approved, Investigational, Nutraceutical
TriamcinoloneThe serum concentration of Triamcinolone can be decreased when it is combined with Mitotane.Approved, Vet Approved
TriazolamThe serum concentration of Triazolam can be decreased when it is combined with Mitotane.Approved
TrimethadioneThe serum concentration of Trimethadione can be decreased when it is combined with Mitotane.Approved
TrimethoprimThe serum concentration of Trimethoprim can be decreased when it is combined with Mitotane.Approved, Vet Approved
TrimipramineThe serum concentration of Trimipramine can be decreased when it is combined with Mitotane.Approved
TroglitazoneThe serum concentration of Troglitazone can be decreased when it is combined with Mitotane.Withdrawn
TroleandomycinThe serum concentration of Troleandomycin can be decreased when it is combined with Mitotane.Approved
UdenafilThe serum concentration of Udenafil can be decreased when it is combined with Mitotane.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be decreased when it is combined with Mitotane.Approved
ValdecoxibThe serum concentration of Valdecoxib can be decreased when it is combined with Mitotane.Investigational, Withdrawn
VandetanibThe serum concentration of Vandetanib can be decreased when it is combined with Mitotane.Approved
VanoxerineThe serum concentration of Vanoxerine can be decreased when it is combined with Mitotane.Investigational
VardenafilThe serum concentration of Vardenafil can be decreased when it is combined with Mitotane.Approved
VemurafenibThe serum concentration of Vemurafenib can be decreased when it is combined with Mitotane.Approved
VenetoclaxThe serum concentration of Venetoclax can be decreased when it is combined with Mitotane.Approved
VenlafaxineThe serum concentration of Venlafaxine can be decreased when it is combined with Mitotane.Approved
VerapamilThe serum concentration of Verapamil can be decreased when it is combined with Mitotane.Approved
VicrivirocThe serum concentration of Vicriviroc can be decreased when it is combined with Mitotane.Investigational
VilanterolThe serum concentration of Vilanterol can be decreased when it is combined with Mitotane.Approved
VilazodoneThe serum concentration of Vilazodone can be decreased when it is combined with Mitotane.Approved
VinblastineThe serum concentration of Vinblastine can be decreased when it is combined with Mitotane.Approved
VincristineThe serum concentration of Vincristine can be decreased when it is combined with Mitotane.Approved, Investigational
VindesineThe serum concentration of Vindesine can be decreased when it is combined with Mitotane.Approved
VinorelbineThe serum concentration of Vinorelbine can be decreased when it is combined with Mitotane.Approved, Investigational
VismodegibThe serum concentration of Vismodegib can be decreased when it is combined with Mitotane.Approved
VorapaxarThe serum concentration of Vorapaxar can be decreased when it is combined with Mitotane.Approved
VoriconazoleThe serum concentration of Voriconazole can be decreased when it is combined with Mitotane.Approved, Investigational
VortioxetineThe serum concentration of Vortioxetine can be decreased when it is combined with Mitotane.Approved
WarfarinThe serum concentration of Warfarin can be decreased when it is combined with Mitotane.Approved
YohimbineThe serum concentration of Yohimbine can be decreased when it is combined with Mitotane.Approved, Vet Approved
ZafirlukastThe serum concentration of Zafirlukast can be decreased when it is combined with Mitotane.Approved, Investigational
ZalcitabineThe serum concentration of Zalcitabine can be decreased when it is combined with Mitotane.Approved
ZaleplonThe serum concentration of Zaleplon can be decreased when it is combined with Mitotane.Approved, Illicit, Investigational
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Mitotane.Approved
ZileutonThe serum concentration of Zileuton can be decreased when it is combined with Mitotane.Approved, Investigational, Withdrawn
ZiprasidoneThe serum concentration of Ziprasidone can be decreased when it is combined with Mitotane.Approved
ZolpidemThe serum concentration of Zolpidem can be decreased when it is combined with Mitotane.Approved
ZomepiracThe serum concentration of Zomepirac can be decreased when it is combined with Mitotane.Withdrawn
ZonisamideThe serum concentration of Zonisamide can be decreased when it is combined with Mitotane.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be decreased when it is combined with Mitotane.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be decreased when it is combined with Mitotane.Approved, Investigational
Food Interactions
  • Take without regard to meals.
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesL01XX23
AHFS Codes
  • 10:00.00
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (57 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9942
Blood Brain Barrier+0.9905
Caco-2 permeable+0.8815
P-glycoprotein substrateNon-substrate0.8053
P-glycoprotein inhibitor INon-inhibitor0.9004
P-glycoprotein inhibitor IINon-inhibitor0.988
Renal organic cation transporterNon-inhibitor0.7959
CYP450 2C9 substrateNon-substrate0.7899
CYP450 2D6 substrateNon-substrate0.818
CYP450 3A4 substrateNon-substrate0.7045
CYP450 1A2 substrateInhibitor0.9542
CYP450 2C9 inhibitorInhibitor0.7241
CYP450 2D6 inhibitorNon-inhibitor0.9349
CYP450 2C19 inhibitorInhibitor0.8993
CYP450 3A4 inhibitorNon-inhibitor0.8629
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.8
Ames testNon AMES toxic0.9751
CarcinogenicityNon-carcinogens0.575
BiodegradationNot ready biodegradable0.9596
Rat acute toxicity2.1911 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9221
hERG inhibition (predictor II)Non-inhibitor0.875
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Bristol myers squibb
Packagers
Dosage forms
FormRouteStrength
TabletOral500 mg/1
TabletOral500 mg
Prices
Unit descriptionCostUnit
Mitotane powder7.75USD g
Lysodren 500 mg tablet5.13USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point77 °CPhysProp
water solubility0.1 mg/L (at 25 °C)BIGGAR,JW & RIGGS,RI (1974)
logP6Not Available
logS-6.51ADME Research, USCD
Predicted Properties
PropertyValueSource
Water Solubility9.42e-06 mg/mLALOGPS
logP6.08ALOGPS
logP6.11ChemAxon
logS-7.5ALOGPS
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity79.97 m3·mol-1ChemAxon
Polarizability29.93 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (8.84 KB)
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
MSMass Spectrum (Electron Ionization)splash10-000i-2690000000-770065ddc57899130a31View in MoNA
1D NMR1H NMR SpectrumNot Available
1D NMR13C NMR SpectrumNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassDiphenylmethanes
Direct ParentDiphenylmethanes
Alternative Parents
Substituents
  • Diphenylmethane
  • Halobenzene
  • Chlorobenzene
  • Aryl halide
  • Aryl chloride
  • Hydrocarbon derivative
  • Organochloride
  • Organohalogen compound
  • Alkyl halide
  • Alkyl chloride
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External DescriptorsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inducer
General Function:
Steroid 11-beta-monooxygenase activity
Specific Function:
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.
Gene Name:
CYP11B1
Uniprot ID:
P15538
Molecular Weight:
57572.44 Da
References
  1. Lindhe O, Skogseid B, Brandt I: Cytochrome P450-catalyzed binding of 3-methylsulfonyl-DDE and o,p'-DDD in human adrenal zona fasciculata/reticularis. J Clin Endocrinol Metab. 2002 Mar;87(3):1319-26. [PubMed:11889204 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
unknown
General Function:
Iron ion binding
Specific Function:
Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage.
Gene Name:
FDX1
Uniprot ID:
P10109
Molecular Weight:
19392.475 Da
References
  1. Kandul SV, Iatsyk MI, Kononenko VIa: [Comparative study of the effect of chloditan on the concentration of cytochrome P-450 and adrenodoxin in various organs of the dog and rat]. Fiziol Zh. 1986 Sep-Oct;32(5):579-84. [PubMed:3770229 ]
  2. Cabrini DA, Campos MM, Tratsk KS, Merino VF, Silva JA Jr, Souza GE, Avellar MC, Pesquero JB, Calixto JB: Molecular and pharmacological evidence for modulation of kinin B(1) receptor expression by endogenous glucocorticoids hormones in rats. Br J Pharmacol. 2001 Jan;132(2):567-77. [PubMed:11159707 ]
  3. Cai W, Counsell RE, Schteingart DE, Sinsheimer JE, Vaz AD, Wotring LL: Adrenal proteins bound by a reactive intermediate of mitotane. Cancer Chemother Pharmacol. 1997;39(6):537-40. [PubMed:9118466 ]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Androgen binding
Specific Function:
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.
Gene Name:
SHBG
Uniprot ID:
P04278
Molecular Weight:
43778.755 Da
References
  1. Nader N, Raverot G, Emptoz-Bonneton A, Dechaud H, Bonnay M, Baudin E, Pugeat M: Mitotane has an estrogenic effect on sex hormone-binding globulin and corticosteroid-binding globulin in humans. J Clin Endocrinol Metab. 2006 Jun;91(6):2165-70. Epub 2006 Mar 21. [PubMed:16551731 ]
  2. van Seters AP, Moolenaar AJ: Mitotane increases the blood levels of hormone-binding proteins. Acta Endocrinol (Copenh). 1991 May;124(5):526-33. [PubMed:1903011 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Steroid binding
Specific Function:
Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
Gene Name:
SERPINA6
Uniprot ID:
P08185
Molecular Weight:
45140.49 Da
References
  1. Nader N, Raverot G, Emptoz-Bonneton A, Dechaud H, Bonnay M, Baudin E, Pugeat M: Mitotane has an estrogenic effect on sex hormone-binding globulin and corticosteroid-binding globulin in humans. J Clin Endocrinol Metab. 2006 Jun;91(6):2165-70. Epub 2006 Mar 21. [PubMed:16551731 ]
  2. Tron'ko MD: [Effect of chlodithane (o,p'-DDD) on transcortin binding ability in Itsenko-Cushing's disease]. Fiziol Zh. 1970 Nov-Dec;16(6):844-5. [PubMed:5520073 ]
Comments
comments powered by Disqus
Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23