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Identification
NameAbiraterone
Accession NumberDB05812
TypeSmall Molecule
GroupsApproved
DescriptionAbiraterone is a derivative of steroidal progesterone and is an innovative drug that offers clinical benefit to patients with hormone refractory prostate cancer. Abiraterone is administered as an acetate salt prodrug because it has a higher bioavailability and less susceptible to hydrolysis than abiraterone itself. FDA approved on April 28, 2011.
Structure
Thumb
Synonyms
(3β)-17-(pyridin-3-yl)androsta-5,16-dien-3-ol
17-(3-Pyridyl)androsta-5,16-dien-3beta-ol
External Identifiers
  • CB 7598
  • CB-7598
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
ZytigaTablet250 mgOralJanssen Inc2011-07-28Not applicableCanada
ZytigaTablet250 mg/1OralJanssen Biotech, Inc.2011-04-28Not applicableUs
ZytigaTablet500 mgOralJanssen Inc2016-09-22Not applicableCanada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Abiraterone acetate
154229-18-2
Thumb
  • InChI Key: UVIQSJCZCSLXRZ-UBUQANBQSA-N
  • Monoisotopic Mass: 391.251129307
  • Average Mass: 391.555
DBSALT001173
Categories
UNIIG819A456D0
CAS number154229-19-3
WeightAverage: 349.509
Monoisotopic: 349.240564619
Chemical FormulaC24H31NO
InChI KeyGZOSMCIZMLWJML-VJLLXTKPSA-N
InChI
InChI=1S/C24H31NO/c1-23-11-9-18(26)14-17(23)5-6-19-21-8-7-20(16-4-3-13-25-15-16)24(21,2)12-10-22(19)23/h3-5,7,13,15,18-19,21-22,26H,6,8-12,14H2,1-2H3/t18-,19-,21-,22-,23-,24+/m0/s1
IUPAC Name
(1S,2R,5S,10R,11S,15S)-2,15-dimethyl-14-(pyridin-3-yl)tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-7,13-dien-5-ol
SMILES
[H][C@@]12CC=C(C3=CC=CN=C3)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@@H](O)CC[C@]12C
Pharmacology
IndicationUsed in combination with prednisone for the treatment of metastatic, castration-resistant prostate cancer.
Structured Indications
PharmacodynamicsAbiraterone is associated with decreases in PSA levels, tumor shrinkage (as evaluated by RECIST criteria), radiographic regression of bone metastases and improvement in pain. Levels of adrenocorticotropic hormones increased up to 6-fold but this can be suppressed by dexamethasone.
Mechanism of actionAbiraterone is an orally active inhibitor of the steroidal enzyme CYP17A1 (17 alpha-hydroxylase/C17,20 lyase). It inhibits CYP17A1 in a selective and irreversible manner via covalent binding mechanism. CYP17A1 is an enzyme that catalyzes the biosynthesis of androgen and is highly expressed in testicular, adrenal, and prostatic tumor tissue. More specifically, abiraterone inhibits the conversion of 17-hydroxyprognenolone to dehydroepiandrosterone (DHEA) by the enzyme CYP17A1 to decrease serum levels of testosterone and other androgens.
TargetKindPharmacological actionActionsOrganismUniProt ID
Steroid 17-alpha-hydroxylase/17,20 lyaseProteinyes
inhibitor
HumanP05093 details
Related Articles
AbsorptionAbiraterone itself is poorly absorbed and is susceptible to hydrolysis by esterases. The salt form, abiraterone acetate, is a prodrug which has a much higher oral bioavailability and is also esterase resistant. Peak drug concentrations of abiraterone were reached in 1.5 - 4 hours. Abiraterone acetate was rapidly and completely deacetylated into abiraterone-the parent salt form was not detectable in early pharmacokinetic studies. Food and high fat meals increases absorption 4.4-fold.
Volume of distribution

Vdss= 19,669 ± 13,358 L

Protein binding>99% protein bound to alpha-1-acid glycoprotein and albumin.
Metabolism

Abiraterone acetate is hydrolyzed into active metabolite abiraterone via esterases. CYP3A4 and SULT2A1 further metabolizes abiraterone into two inactive metabolites called abiraterone sulfate and N-oxide abiraterone sulfate.

SubstrateEnzymesProduct
Abiraterone
Not Available
abiraterone sulfateDetails
Abiraterone
Not Available
N-oxide abiraterone sulfateDetails
Route of eliminationExcreted via feces (~88%) and urine (~5%)
Half lifeTerminal elimination half-life = 5-14 hours
ClearanceNot Available
ToxicityToxicity is related to the blockade of 17α-hydroxylase activity. Blockade results in the accumulation of upstream mineralocorticoids like 11-deoxycorticosterone leading to secondary hyperaldosteronism. Signs of hydroaldosteronism include fluid retention and hypokalemia. Mineralocorticoid receptor antagonists may be used to treat signs and symptoms.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
4-MethoxyamphetamineThe serum concentration of 4-Methoxyamphetamine can be increased when it is combined with Abiraterone.Experimental, Illicit
AceclofenacThe metabolism of Aceclofenac can be decreased when combined with Abiraterone.Approved
AcenocoumarolThe serum concentration of Acenocoumarol can be increased when it is combined with Abiraterone.Approved
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Abiraterone.Approved
AcetylcholineThe serum concentration of Acetylcholine can be increased when it is combined with Abiraterone.Approved
AcetyldigitoxinAcetyldigitoxin may decrease the cardiotoxic activities of Abiraterone.Approved
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Abiraterone.Approved, Vet Approved
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Abiraterone.Approved
AgomelatineThe serum concentration of Agomelatine can be increased when it is combined with Abiraterone.Approved, Investigational
AjmalineThe serum concentration of Ajmaline can be increased when it is combined with Abiraterone.Approved
AlbendazoleThe serum concentration of Albendazole can be increased when it is combined with Abiraterone.Approved, Vet Approved
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Abiraterone.Approved, Investigational
AlogliptinThe serum concentration of Alogliptin can be increased when it is combined with Abiraterone.Approved
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Abiraterone.Approved, Withdrawn
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Abiraterone.Approved, Illicit, Investigational
AlprenololThe serum concentration of Alprenolol can be increased when it is combined with Abiraterone.Approved, Withdrawn
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Abiraterone.Approved, Investigational
AminophenazoneThe serum concentration of Aminophenazone can be increased when it is combined with Abiraterone.Approved, Withdrawn
AminophyllineThe serum concentration of Aminophylline can be increased when it is combined with Abiraterone.Approved
AmiodaroneThe serum concentration of Amiodarone can be increased when it is combined with Abiraterone.Approved, Investigational
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Abiraterone.Approved
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Abiraterone.Approved
AmoxapineThe serum concentration of Amoxapine can be increased when it is combined with Abiraterone.Approved
AmoxicillinThe metabolism of Amoxicillin can be decreased when combined with Abiraterone.Approved, Vet Approved
AmphetamineThe serum concentration of Amphetamine can be increased when it is combined with Abiraterone.Approved, Illicit
AmprenavirThe serum concentration of Amprenavir can be increased when it is combined with Abiraterone.Approved
AmsacrineThe serum concentration of Amsacrine can be increased when it is combined with Abiraterone.Approved
AnagrelideThe serum concentration of Anagrelide can be increased when it is combined with Abiraterone.Approved
AntipyrineThe serum concentration of Antipyrine can be increased when it is combined with Abiraterone.Approved
AnvirzelAnvirzel may decrease the cardiotoxic activities of Abiraterone.Investigational
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Abiraterone.Approved
AprepitantThe serum concentration of Aprepitant can be increased when it is combined with Abiraterone.Approved, Investigational
AprindineThe serum concentration of Aprindine can be increased when it is combined with Abiraterone.Approved
Arachidonic AcidThe metabolism of Arachidonic Acid can be decreased when combined with Abiraterone.Experimental
ArformoterolThe serum concentration of Arformoterol can be increased when it is combined with Abiraterone.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Abiraterone.Approved, Investigational
ArtemetherThe serum concentration of Artemether can be increased when it is combined with Abiraterone.Approved
ASA404The serum concentration of ASA404 can be increased when it is combined with Abiraterone.Investigational
AsenapineThe serum concentration of Asenapine can be increased when it is combined with Abiraterone.Approved
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Abiraterone.Approved, Withdrawn
AtazanavirThe metabolism of Abiraterone can be decreased when combined with Atazanavir.Approved, Investigational
AtomoxetineThe serum concentration of Atomoxetine can be increased when it is combined with Abiraterone.Approved
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Abiraterone.Approved
AV650The serum concentration of AV650 can be increased when it is combined with Abiraterone.Approved, Investigational
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Abiraterone.Approved, Investigational
AzelastineThe serum concentration of Azelastine can be increased when it is combined with Abiraterone.Approved
BendamustineThe serum concentration of Bendamustine can be increased when it is combined with Abiraterone.Approved, Investigational
BenzatropineThe serum concentration of Benzatropine can be increased when it is combined with Abiraterone.Approved
Benzyl alcoholThe serum concentration of Benzyl alcohol can be increased when it is combined with Abiraterone.Approved
BepridilThe serum concentration of Bepridil can be increased when it is combined with Abiraterone.Approved, Withdrawn
BeraprostThe serum concentration of Beraprost can be increased when it is combined with Abiraterone.Investigational
BetaxololThe serum concentration of Betaxolol can be increased when it is combined with Abiraterone.Approved
BevacizumabBevacizumab may increase the cardiotoxic activities of Abiraterone.Approved, Investigational
BexaroteneThe serum concentration of Abiraterone can be decreased when it is combined with Bexarotene.Approved, Investigational
BisoprololThe serum concentration of Bisoprolol can be increased when it is combined with Abiraterone.Approved
BoceprevirThe metabolism of Abiraterone can be decreased when combined with Boceprevir.Approved
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Abiraterone.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Abiraterone.Approved, Investigational
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Abiraterone.Approved
BromazepamThe serum concentration of Bromazepam can be increased when it is combined with Abiraterone.Approved, Illicit
BrompheniramineThe serum concentration of Brompheniramine can be increased when it is combined with Abiraterone.Approved
BufuralolThe serum concentration of Bufuralol can be increased when it is combined with Abiraterone.Experimental, Investigational
BupivacaineThe serum concentration of Bupivacaine can be increased when it is combined with Abiraterone.Approved, Investigational
BuprenorphineThe serum concentration of Buprenorphine can be increased when it is combined with Abiraterone.Approved, Illicit, Investigational, Vet Approved
BupropionThe serum concentration of Bupropion can be increased when it is combined with Abiraterone.Approved
BuspironeThe serum concentration of Buspirone can be increased when it is combined with Abiraterone.Approved, Investigational
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Abiraterone.Approved
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Abiraterone.Approved
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Abiraterone.Approved
CandesartanThe metabolism of Candesartan can be decreased when combined with Abiraterone.Approved
CaptoprilThe serum concentration of Captopril can be increased when it is combined with Abiraterone.Approved
CarbamazepineThe serum concentration of Abiraterone can be decreased when it is combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe serum concentration of Carbinoxamine can be increased when it is combined with Abiraterone.Approved
CariprazineThe serum concentration of Cariprazine can be increased when it is combined with Abiraterone.Approved
CarisoprodolThe metabolism of Carisoprodol can be decreased when combined with Abiraterone.Approved
CarmustineThe serum concentration of Carmustine can be increased when it is combined with Abiraterone.Approved
CarteololThe serum concentration of Carteolol can be increased when it is combined with Abiraterone.Approved
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Abiraterone.Approved, Investigational
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Abiraterone.Approved, Investigational
CephalexinThe serum concentration of Cephalexin can be increased when it is combined with Abiraterone.Approved, Vet Approved
CeritinibThe serum concentration of Abiraterone can be increased when it is combined with Ceritinib.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Abiraterone.Withdrawn
CevimelineThe serum concentration of Cevimeline can be increased when it is combined with Abiraterone.Approved
ChloramphenicolThe metabolism of Chloramphenicol can be decreased when combined with Abiraterone.Approved, Vet Approved
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be increased when it is combined with Abiraterone.Approved, Illicit
ChloroquineThe serum concentration of Chloroquine can be increased when it is combined with Abiraterone.Approved, Vet Approved
ChlorphenamineThe serum concentration of Chlorphenamine can be increased when it is combined with Abiraterone.Approved
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Abiraterone.Approved, Vet Approved
ChlorpropamideThe metabolism of Chlorpropamide can be decreased when combined with Abiraterone.Approved
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be increased when it is combined with Abiraterone.Approved
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Abiraterone.Approved
CinacalcetThe serum concentration of Cinacalcet can be increased when it is combined with Abiraterone.Approved
CinnarizineThe serum concentration of Cinnarizine can be increased when it is combined with Abiraterone.Approved
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Abiraterone.Approved, Investigational, Withdrawn
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Abiraterone.Approved
ClarithromycinThe metabolism of Abiraterone can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Abiraterone can be decreased when combined with Clemastine.Approved
ClenbuterolThe serum concentration of Clenbuterol can be increased when it is combined with Abiraterone.Approved, Vet Approved
ClevidipineThe serum concentration of Clevidipine can be increased when it is combined with Abiraterone.Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Abiraterone.Approved, Illicit
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Abiraterone.Investigational
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Abiraterone.Approved, Vet Approved
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Abiraterone.Approved
ClopidogrelThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Abiraterone resulting in a loss in efficacy.Approved, Nutraceutical
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Abiraterone.Approved, Illicit
ClotrimazoleThe metabolism of Abiraterone can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Abiraterone.Approved
CobicistatThe metabolism of Abiraterone can be decreased when combined with Cobicistat.Approved
CodeineThe serum concentration of Codeine can be increased when it is combined with Abiraterone.Approved, Illicit
ConivaptanThe serum concentration of Abiraterone can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Abiraterone.Approved
CrizotinibThe metabolism of Abiraterone can be decreased when combined with Crizotinib.Approved
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Abiraterone.Approved
CyclophosphamideThe serum concentration of Cyclophosphamide can be increased when it is combined with Abiraterone.Approved, Investigational
CyclosporineThe metabolism of Abiraterone can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
DabrafenibThe serum concentration of Abiraterone can be decreased when it is combined with Dabrafenib.Approved
DacarbazineThe serum concentration of Dacarbazine can be increased when it is combined with Abiraterone.Approved, Investigational
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Abiraterone.Approved
DapsoneThe serum concentration of Dapsone can be increased when it is combined with Abiraterone.Approved, Investigational
DarifenacinThe serum concentration of Darifenacin can be increased when it is combined with Abiraterone.Approved, Investigational
DarunavirThe metabolism of Abiraterone can be decreased when combined with Darunavir.Approved
DasabuvirThe serum concentration of Dasabuvir can be increased when it is combined with Abiraterone.Approved
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Abiraterone.Approved, Investigational
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Abiraterone.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Abiraterone.Approved
DeferasiroxThe serum concentration of Abiraterone can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe serum concentration of Delavirdine can be increased when it is combined with Abiraterone.Approved
DesipramineThe serum concentration of Desipramine can be increased when it is combined with Abiraterone.Approved
DeslanosideDeslanoside may decrease the cardiotoxic activities of Abiraterone.Approved
DexamethasoneThe serum concentration of Abiraterone can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DexfenfluramineThe serum concentration of Dexfenfluramine can be increased when it is combined with Abiraterone.Approved, Illicit, Withdrawn
DexmethylphenidateThe serum concentration of Dexmethylphenidate can be increased when it is combined with Abiraterone.Approved
DextroamphetamineThe serum concentration of Dextroamphetamine can be increased when it is combined with Abiraterone.Approved, Illicit
DextromethorphanThe serum concentration of Dextromethorphan can be increased when it is combined with Abiraterone.Approved
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Abiraterone.Approved, Illicit, Vet Approved
DiclofenacThe serum concentration of Diclofenac can be increased when it is combined with Abiraterone.Approved, Vet Approved
DicoumarolThe metabolism of Dicoumarol can be decreased when combined with Abiraterone.Approved
DigitoxinDigitoxin may decrease the cardiotoxic activities of Abiraterone.Approved
DigoxinDigoxin may decrease the cardiotoxic activities of Abiraterone.Approved
DihydrocodeineThe serum concentration of Dihydrocodeine can be increased when it is combined with Abiraterone.Approved, Illicit
DihydroergotamineThe metabolism of Abiraterone can be decreased when combined with Dihydroergotamine.Approved
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Abiraterone.Approved
DinoprostoneThe serum concentration of Dinoprostone can be increased when it is combined with Abiraterone.Approved
DiphenhydramineThe serum concentration of Diphenhydramine can be increased when it is combined with Abiraterone.Approved
DocetaxelThe risk or severity of adverse effects can be increased when Docetaxel is combined with Abiraterone.Approved, Investigational
DolasetronThe serum concentration of Dolasetron can be increased when it is combined with Abiraterone.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Abiraterone.Approved, Investigational, Vet Approved
DonepezilThe serum concentration of Donepezil can be increased when it is combined with Abiraterone.Approved
DopamineThe serum concentration of Dopamine can be increased when it is combined with Abiraterone.Approved
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Abiraterone.Approved
DoxazosinThe serum concentration of Doxazosin can be increased when it is combined with Abiraterone.Approved
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Abiraterone.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Abiraterone.Approved, Investigational
DoxycyclineThe metabolism of Abiraterone can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Abiraterone.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Abiraterone.Approved
DuloxetineThe serum concentration of Duloxetine can be increased when it is combined with Abiraterone.Approved
EfavirenzThe serum concentration of Abiraterone can be decreased when it is combined with Efavirenz.Approved, Investigational
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Abiraterone.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Abiraterone.Approved
EltrombopagThe serum concentration of Eltrombopag can be increased when it is combined with Abiraterone.Approved
EncainideThe serum concentration of Encainide can be increased when it is combined with Abiraterone.Approved, Withdrawn
EnclomipheneThe serum concentration of Enclomiphene can be increased when it is combined with Abiraterone.Investigational
EnfuvirtideThe metabolism of Enfuvirtide can be decreased when combined with Abiraterone.Approved, Investigational
EnzalutamideThe serum concentration of Abiraterone can be decreased when it is combined with Enzalutamide.Approved
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Abiraterone.Approved, Investigational
EpoprostenolThe metabolism of Epoprostenol can be decreased when combined with Abiraterone.Approved
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Abiraterone.Approved
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Abiraterone.Approved, Investigational
ErythromycinThe metabolism of Abiraterone can be decreased when combined with Erythromycin.Approved, Vet Approved
EscitalopramThe serum concentration of Escitalopram can be increased when it is combined with Abiraterone.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Abiraterone can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsmirtazapineThe serum concentration of Esmirtazapine can be increased when it is combined with Abiraterone.Investigational
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Abiraterone.Approved, Investigational
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Abiraterone.Approved, Investigational, Vet Approved
EstroneThe serum concentration of Estrone can be increased when it is combined with Abiraterone.Approved
Estrone sulfateThe serum concentration of Estrone sulfate can be increased when it is combined with Abiraterone.Approved
EszopicloneThe serum concentration of Eszopiclone can be increased when it is combined with Abiraterone.Approved
EthanolThe serum concentration of Ethanol can be increased when it is combined with Abiraterone.Approved
EthylmorphineThe serum concentration of Ethylmorphine can be increased when it is combined with Abiraterone.Approved, Illicit
EtodolacThe metabolism of Etodolac can be decreased when combined with Abiraterone.Approved, Investigational, Vet Approved
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Abiraterone.Approved
EtoricoxibThe serum concentration of Etoricoxib can be increased when it is combined with Abiraterone.Approved, Investigational
EtravirineThe serum concentration of Abiraterone can be decreased when it is combined with Etravirine.Approved
FamotidineThe metabolism of Famotidine can be decreased when combined with Abiraterone.Approved
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Abiraterone.Approved
FingolimodThe serum concentration of Fingolimod can be increased when it is combined with Abiraterone.Approved, Investigational
FlecainideThe serum concentration of Flecainide can be increased when it is combined with Abiraterone.Approved, Withdrawn
FluconazoleThe metabolism of Abiraterone can be decreased when combined with Fluconazole.Approved
FlunarizineThe serum concentration of Flunarizine can be increased when it is combined with Abiraterone.Approved
FlunitrazepamThe serum concentration of Flunitrazepam can be increased when it is combined with Abiraterone.Approved, Illicit
FluorouracilThe serum concentration of Fluorouracil can be increased when it is combined with Abiraterone.Approved
FluoxetineThe serum concentration of Fluoxetine can be increased when it is combined with Abiraterone.Approved, Vet Approved
FluphenazineThe serum concentration of Fluphenazine can be increased when it is combined with Abiraterone.Approved
FlurbiprofenThe metabolism of Flurbiprofen can be decreased when combined with Abiraterone.Approved, Investigational
FlutamideThe serum concentration of Flutamide can be increased when it is combined with Abiraterone.Approved
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Abiraterone.Approved
FluvoxamineThe serum concentration of Fluvoxamine can be increased when it is combined with Abiraterone.Approved, Investigational
FormoterolThe serum concentration of Formoterol can be increased when it is combined with Abiraterone.Approved, Investigational
FosamprenavirThe metabolism of Abiraterone can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Abiraterone can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe serum concentration of Abiraterone can be decreased when it is combined with Fosphenytoin.Approved
FrovatriptanThe serum concentration of Frovatriptan can be increased when it is combined with Abiraterone.Approved, Investigational
Fusidic AcidThe serum concentration of Abiraterone can be increased when it is combined with Fusidic Acid.Approved
GalantamineThe serum concentration of Galantamine can be increased when it is combined with Abiraterone.Approved
GavestinelThe metabolism of Gavestinel can be decreased when combined with Abiraterone.Investigational
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Abiraterone.Approved, Investigational
GenisteinThe serum concentration of Genistein can be increased when it is combined with Abiraterone.Investigational
GliclazideThe metabolism of Gliclazide can be decreased when combined with Abiraterone.Approved
GlimepirideThe metabolism of Glimepiride can be decreased when combined with Abiraterone.Approved
GlipizideThe metabolism of Glipizide can be decreased when combined with Abiraterone.Approved
GlucosamineThe metabolism of Glucosamine can be decreased when combined with Abiraterone.Approved
GlyburideThe metabolism of Glyburide can be decreased when combined with Abiraterone.Approved
GranisetronThe serum concentration of Granisetron can be increased when it is combined with Abiraterone.Approved, Investigational
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Abiraterone.Withdrawn
GuanabenzThe serum concentration of Guanabenz can be increased when it is combined with Abiraterone.Approved
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Abiraterone.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Abiraterone.Approved
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Abiraterone.Approved
HalothaneThe serum concentration of Halothane can be increased when it is combined with Abiraterone.Approved, Vet Approved
HesperetinThe serum concentration of Hesperetin can be increased when it is combined with Abiraterone.Approved
HexobarbitalThe serum concentration of Hexobarbital can be increased when it is combined with Abiraterone.Approved
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Abiraterone.Approved
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Abiraterone.Approved, Illicit
HydromorphoneThe serum concentration of Hydromorphone can be increased when it is combined with Abiraterone.Approved, Illicit
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Abiraterone.Approved
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Abiraterone.Approved
IdarubicinThe serum concentration of Idarubicin can be increased when it is combined with Abiraterone.Approved
IdelalisibThe serum concentration of Abiraterone can be increased when it is combined with Idelalisib.Approved
IfosfamideThe serum concentration of Ifosfamide can be increased when it is combined with Abiraterone.Approved
IloperidoneThe serum concentration of Iloperidone can be increased when it is combined with Abiraterone.Approved
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Abiraterone.Approved
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Abiraterone.Approved
ImiquimodThe serum concentration of Imiquimod can be increased when it is combined with Abiraterone.Approved, Investigational
IndinavirThe metabolism of Abiraterone can be decreased when combined with Indinavir.Approved
indisulamThe metabolism of indisulam can be decreased when combined with Abiraterone.Investigational
IndomethacinThe metabolism of Indomethacin can be decreased when combined with Abiraterone.Approved, Investigational
Ipratropium bromideThe serum concentration of Ipratropium bromide can be increased when it is combined with Abiraterone.Approved
IrbesartanThe serum concentration of Irbesartan can be increased when it is combined with Abiraterone.Approved, Investigational
IsavuconazoniumThe metabolism of Abiraterone can be decreased when combined with Isavuconazonium.Approved, Investigational
IsradipineThe metabolism of Abiraterone can be decreased when combined with Isradipine.Approved
ItraconazoleThe metabolism of Abiraterone can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Abiraterone can be increased when it is combined with Ivacaftor.Approved
IxazomibThe serum concentration of Ixazomib can be increased when it is combined with Abiraterone.Approved
KetamineThe serum concentration of Ketamine can be increased when it is combined with Abiraterone.Approved, Vet Approved
KetobemidoneThe serum concentration of Ketobemidone can be increased when it is combined with Abiraterone.Approved
KetoconazoleThe metabolism of Abiraterone can be decreased when combined with Ketoconazole.Approved, Investigational
KetoprofenThe metabolism of Ketoprofen can be decreased when combined with Abiraterone.Approved, Vet Approved
LabetalolThe serum concentration of Labetalol can be increased when it is combined with Abiraterone.Approved
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Abiraterone.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Abiraterone.Approved, Investigational
LeflunomideThe serum concentration of Leflunomide can be increased when it is combined with Abiraterone.Approved, Investigational
LesinuradThe metabolism of Lesinurad can be decreased when combined with Abiraterone.Approved
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Abiraterone.Approved
LevodopaThe serum concentration of Levodopa can be increased when it is combined with Abiraterone.Approved
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Abiraterone.Approved
LicofeloneThe serum concentration of Licofelone can be increased when it is combined with Abiraterone.Investigational
LidocaineThe serum concentration of Lidocaine can be increased when it is combined with Abiraterone.Approved, Vet Approved
LisurideThe serum concentration of Lisuride can be increased when it is combined with Abiraterone.Approved
LomefloxacinThe serum concentration of Lomefloxacin can be increased when it is combined with Abiraterone.Approved
LomustineThe serum concentration of Lomustine can be increased when it is combined with Abiraterone.Approved
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Abiraterone.Approved
LopinavirThe metabolism of Abiraterone can be decreased when combined with Lopinavir.Approved
LoratadineThe serum concentration of Loratadine can be increased when it is combined with Abiraterone.Approved
LorcaserinThe serum concentration of Lorcaserin can be increased when it is combined with Abiraterone.Approved
LornoxicamThe metabolism of Lornoxicam can be decreased when combined with Abiraterone.Approved
LosartanThe serum concentration of Losartan can be increased when it is combined with Abiraterone.Approved
LovastatinThe metabolism of Abiraterone can be decreased when combined with Lovastatin.Approved, Investigational
LuliconazoleThe serum concentration of Abiraterone can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Abiraterone can be decreased when it is combined with Lumacaftor.Approved
LumiracoxibThe serum concentration of Lumiracoxib can be increased when it is combined with Abiraterone.Approved, Investigational
MacitentanThe metabolism of Macitentan can be decreased when combined with Abiraterone.Approved
MalathionThe serum concentration of Malathion can be increased when it is combined with Abiraterone.Approved, Investigational
MaprotilineThe serum concentration of Maprotiline can be increased when it is combined with Abiraterone.Approved
Mefenamic acidThe serum concentration of Mefenamic acid can be increased when it is combined with Abiraterone.Approved
MelatoninThe serum concentration of Melatonin can be increased when it is combined with Abiraterone.Approved, Nutraceutical, Vet Approved
MeloxicamThe serum concentration of Meloxicam can be increased when it is combined with Abiraterone.Approved, Vet Approved
MenadioneThe serum concentration of Menadione can be increased when it is combined with Abiraterone.Approved, Nutraceutical
MephenytoinThe serum concentration of Mephenytoin can be increased when it is combined with Abiraterone.Investigational, Withdrawn
MeprobamateThe metabolism of Meprobamate can be decreased when combined with Abiraterone.Approved, Illicit
MequitazineThe serum concentration of Mequitazine can be increased when it is combined with Abiraterone.Approved
MesoridazineThe serum concentration of Mesoridazine can be increased when it is combined with Abiraterone.Approved
MestranolThe metabolism of Mestranol can be decreased when combined with Abiraterone.Approved
MethadoneThe serum concentration of Methadone can be increased when it is combined with Abiraterone.Approved
MethamphetamineThe serum concentration of Methamphetamine can be increased when it is combined with Abiraterone.Approved, Illicit
MethotrimeprazineThe serum concentration of Methotrimeprazine can be increased when it is combined with Abiraterone.Approved
MethoxyfluraneThe serum concentration of Methoxyflurane can be increased when it is combined with Abiraterone.Approved, Vet Approved
MethsuximideThe metabolism of Methsuximide can be decreased when combined with Abiraterone.Approved
MethylphenidateThe serum concentration of Methylphenidate can be increased when it is combined with Abiraterone.Approved, Investigational
MethylphenobarbitalThe metabolism of Methylphenobarbital can be decreased when combined with Abiraterone.Approved
MethyprylonThe serum concentration of Methyprylon can be increased when it is combined with Abiraterone.Approved, Illicit, Withdrawn
MetoclopramideThe serum concentration of Metoclopramide can be increased when it is combined with Abiraterone.Approved, Investigational
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Abiraterone.Approved, Investigational
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Abiraterone.Approved
MexiletineThe serum concentration of Mexiletine can be increased when it is combined with Abiraterone.Approved
MianserinThe serum concentration of Mianserin can be increased when it is combined with Abiraterone.Approved
MifepristoneThe serum concentration of Abiraterone can be increased when it is combined with Mifepristone.Approved, Investigational
MinaprineThe serum concentration of Minaprine can be increased when it is combined with Abiraterone.Approved
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Abiraterone.Approved
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Abiraterone.Approved
MitotaneThe serum concentration of Abiraterone can be decreased when it is combined with Mitotane.Approved
MoclobemideThe serum concentration of Moclobemide can be increased when it is combined with Abiraterone.Approved
ModafinilThe serum concentration of Abiraterone can be decreased when it is combined with Modafinil.Approved, Investigational
MontelukastThe metabolism of Montelukast can be decreased when combined with Abiraterone.Approved
MorphineThe serum concentration of Morphine can be increased when it is combined with Abiraterone.Approved, Investigational
muraglitazarThe serum concentration of muraglitazar can be increased when it is combined with Abiraterone.Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Abiraterone.Approved, Investigational
NabumetoneThe serum concentration of Nabumetone can be increased when it is combined with Abiraterone.Approved
NafcillinThe serum concentration of Abiraterone can be decreased when it is combined with Nafcillin.Approved
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Abiraterone.Approved, Vet Approved
NaproxenThe serum concentration of Naproxen can be increased when it is combined with Abiraterone.Approved, Vet Approved
NateglinideThe serum concentration of Nateglinide can be increased when it is combined with Abiraterone.Approved, Investigational
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Abiraterone.Approved, Investigational
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Abiraterone.Approved, Withdrawn
NelfinavirThe metabolism of Abiraterone can be decreased when combined with Nelfinavir.Approved
NetupitantThe serum concentration of Netupitant can be increased when it is combined with Abiraterone.Approved
NevirapineThe serum concentration of Abiraterone can be decreased when it is combined with Nevirapine.Approved
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Abiraterone.Approved
NicergolineThe serum concentration of Nicergoline can be increased when it is combined with Abiraterone.Approved
NiclosamideThe metabolism of Niclosamide can be decreased when combined with Abiraterone.Approved, Vet Approved
NicotineThe serum concentration of Nicotine can be increased when it is combined with Abiraterone.Approved
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Abiraterone.Approved
NilotinibThe metabolism of Abiraterone can be decreased when combined with Nilotinib.Approved, Investigational
NilutamideThe metabolism of Nilutamide can be decreased when combined with Abiraterone.Approved
Nitric OxideThe serum concentration of Nitric Oxide can be increased when it is combined with Abiraterone.Approved
NitrofuralThe serum concentration of Nitrofural can be increased when it is combined with Abiraterone.Approved, Vet Approved
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Abiraterone.Approved
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Abiraterone.Approved, Investigational
OlaparibThe metabolism of Abiraterone can be decreased when combined with Olaparib.Approved
OlodaterolThe serum concentration of Olodaterol can be increased when it is combined with Abiraterone.Approved
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Abiraterone.Approved
OmeprazoleThe serum concentration of Omeprazole can be increased when it is combined with Abiraterone.Approved, Investigational, Vet Approved
OndansetronThe serum concentration of Ondansetron can be increased when it is combined with Abiraterone.Approved
OsimertinibThe serum concentration of Abiraterone can be increased when it is combined with Osimertinib.Approved
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Abiraterone.Approved
OuabainOuabain may decrease the cardiotoxic activities of Abiraterone.Approved
OxaliplatinThe serum concentration of Oxaliplatin can be increased when it is combined with Abiraterone.Approved, Investigational
OxaprozinThe metabolism of Oxaprozin can be decreased when combined with Abiraterone.Approved
OxiconazoleThe metabolism of Oxiconazole can be decreased when combined with Abiraterone.Approved
OxtriphyllineThe serum concentration of Oxtriphylline can be increased when it is combined with Abiraterone.Approved
OxycodoneThe serum concentration of Oxycodone can be increased when it is combined with Abiraterone.Approved, Illicit, Investigational
OxymorphoneThe serum concentration of Oxymorphone can be increased when it is combined with Abiraterone.Approved, Investigational, Vet Approved
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Abiraterone.Approved, Vet Approved
PalbociclibThe serum concentration of Abiraterone can be increased when it is combined with Palbociclib.Approved
PalonosetronThe serum concentration of Palonosetron can be increased when it is combined with Abiraterone.Approved, Investigational
PantoprazoleThe serum concentration of Pantoprazole can be increased when it is combined with Abiraterone.Approved
ParamethadioneThe serum concentration of Paramethadione can be increased when it is combined with Abiraterone.Approved
ParecoxibThe metabolism of Parecoxib can be decreased when combined with Abiraterone.Approved
ParoxetineThe serum concentration of Paroxetine can be increased when it is combined with Abiraterone.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Abiraterone.Approved
PentamidineThe serum concentration of Pentamidine can be increased when it is combined with Abiraterone.Approved
PentobarbitalThe serum concentration of Abiraterone can be decreased when it is combined with Pentobarbital.Approved, Vet Approved
PentoxifyllineThe serum concentration of Pentoxifylline can be increased when it is combined with Abiraterone.Approved, Investigational
PerhexilineThe serum concentration of Perhexiline can be increased when it is combined with Abiraterone.Approved
PerphenazineThe serum concentration of Perphenazine can be increased when it is combined with Abiraterone.Approved
PethidineThe serum concentration of Pethidine can be increased when it is combined with Abiraterone.Approved
PhenacetinThe serum concentration of Phenacetin can be increased when it is combined with Abiraterone.Withdrawn
PhenforminThe serum concentration of Phenformin can be increased when it is combined with Abiraterone.Approved, Withdrawn
PhenobarbitalThe serum concentration of Abiraterone can be decreased when it is combined with Phenobarbital.Approved
PhenprocoumonThe serum concentration of Phenprocoumon can be increased when it is combined with Abiraterone.Approved
PhenylbutazoneThe metabolism of Phenylbutazone can be decreased when combined with Abiraterone.Approved, Vet Approved
PhenytoinThe serum concentration of Abiraterone can be decreased when it is combined with Phenytoin.Approved, Vet Approved
PimozideThe serum concentration of Pimozide can be increased when it is combined with Abiraterone.Approved
PindololThe serum concentration of Pindolol can be increased when it is combined with Abiraterone.Approved
PioglitazoneThe serum concentration of Pioglitazone can be increased when it is combined with Abiraterone.Approved, Investigational
PiperazineThe serum concentration of Piperazine can be increased when it is combined with Abiraterone.Approved, Vet Approved
PipotiazineThe serum concentration of Pipotiazine can be increased when it is combined with Abiraterone.Approved
PirfenidoneThe serum concentration of Pirfenidone can be increased when it is combined with Abiraterone.Investigational
PiroxicamThe serum concentration of Piroxicam can be increased when it is combined with Abiraterone.Approved, Investigational
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Abiraterone.Approved
PodofiloxThe metabolism of Podofilox can be decreased when combined with Abiraterone.Approved
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Abiraterone.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Abiraterone.Approved
PosaconazoleThe metabolism of Abiraterone can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Abiraterone.Approved
PravastatinThe metabolism of Pravastatin can be decreased when combined with Abiraterone.Approved
PraziquantelThe serum concentration of Praziquantel can be increased when it is combined with Abiraterone.Approved, Vet Approved
PrimaquineThe serum concentration of Primaquine can be increased when it is combined with Abiraterone.Approved
PrimidoneThe serum concentration of Abiraterone can be decreased when it is combined with Primidone.Approved, Vet Approved
ProcainamideThe serum concentration of Procainamide can be increased when it is combined with Abiraterone.Approved
ProchlorperazineThe serum concentration of Prochlorperazine can be increased when it is combined with Abiraterone.Approved, Vet Approved
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Abiraterone.Approved, Vet Approved
ProguanilThe serum concentration of Proguanil can be increased when it is combined with Abiraterone.Approved
PromazineThe serum concentration of Promazine can be increased when it is combined with Abiraterone.Approved, Vet Approved
PromethazineThe serum concentration of Promethazine can be increased when it is combined with Abiraterone.Approved
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Abiraterone.Approved
PropofolThe serum concentration of Propofol can be increased when it is combined with Abiraterone.Approved, Investigational, Vet Approved
PropranololThe serum concentration of Propranolol can be increased when it is combined with Abiraterone.Approved, Investigational
ProtriptylineThe serum concentration of Protriptyline can be increased when it is combined with Abiraterone.Approved
PseudoephedrineThe serum concentration of Pseudoephedrine can be increased when it is combined with Abiraterone.Approved
PyrazinamideThe serum concentration of Pyrazinamide can be increased when it is combined with Abiraterone.Approved
QuazepamThe metabolism of Quazepam can be decreased when combined with Abiraterone.Approved, Illicit
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Abiraterone.Approved
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Abiraterone.Approved
QuinineThe serum concentration of Quinine can be increased when it is combined with Abiraterone.Approved
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Abiraterone.Approved, Investigational
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Abiraterone.Approved, Investigational
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Abiraterone.Approved
RanolazineThe metabolism of Abiraterone can be decreased when combined with Ranolazine.Approved, Investigational
RasagilineThe serum concentration of Rasagiline can be increased when it is combined with Abiraterone.Approved
RemoxiprideThe serum concentration of Remoxipride can be increased when it is combined with Abiraterone.Approved, Withdrawn
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Abiraterone.Approved, Investigational
repinotanThe serum concentration of repinotan can be increased when it is combined with Abiraterone.Investigational
ResveratrolThe serum concentration of Resveratrol can be increased when it is combined with Abiraterone.Experimental, Investigational
RifabutinThe serum concentration of Abiraterone can be decreased when it is combined with Rifabutin.Approved
RifampicinThe serum concentration of Abiraterone can be decreased when it is combined with Rifampicin.Approved
RifapentineThe serum concentration of Abiraterone can be decreased when it is combined with Rifapentine.Approved
RiluzoleThe serum concentration of Riluzole can be increased when it is combined with Abiraterone.Approved, Investigational
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Abiraterone.Approved
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Abiraterone.Approved, Investigational
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Abiraterone.Approved, Investigational
RizatriptanThe serum concentration of Rizatriptan can be increased when it is combined with Abiraterone.Approved
RofecoxibThe serum concentration of Rofecoxib can be increased when it is combined with Abiraterone.Investigational, Withdrawn
RomidepsinThe metabolism of Romidepsin can be decreased when combined with Abiraterone.Approved, Investigational
RopiniroleThe serum concentration of Ropinirole can be increased when it is combined with Abiraterone.Approved, Investigational
RopivacaineThe serum concentration of Ropivacaine can be increased when it is combined with Abiraterone.Approved
RosiglitazoneThe serum concentration of Rosiglitazone can be increased when it is combined with Abiraterone.Approved, Investigational
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Abiraterone.Approved
RotigotineThe serum concentration of Rotigotine can be increased when it is combined with Abiraterone.Approved
Salicylic acidThe metabolism of Salicylic acid can be decreased when combined with Abiraterone.Approved, Vet Approved
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Abiraterone.Approved, Investigational
SelegilineThe serum concentration of Selegiline can be increased when it is combined with Abiraterone.Approved, Investigational, Vet Approved
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Abiraterone.Approved
SeratrodastThe serum concentration of Seratrodast can be increased when it is combined with Abiraterone.Approved, Investigational
SertindoleThe serum concentration of Sertindole can be increased when it is combined with Abiraterone.Approved, Withdrawn
SertralineThe serum concentration of Sertraline can be increased when it is combined with Abiraterone.Approved
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Abiraterone.Approved, Investigational
SiltuximabThe serum concentration of Abiraterone can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Abiraterone can be increased when it is combined with Simeprevir.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Abiraterone.Approved
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Abiraterone.Approved, Investigational
SitaxentanThe metabolism of Sitaxentan can be decreased when combined with Abiraterone.Approved, Investigational, Withdrawn
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Abiraterone.Approved, Investigational
SparteineThe serum concentration of Sparteine can be increased when it is combined with Abiraterone.Experimental
SpironolactoneThe therapeutic efficacy of Abiraterone can be decreased when used in combination with Spironolactone.Approved
St. John's WortThe serum concentration of Abiraterone can be decreased when it is combined with St. John's Wort.Nutraceutical
StiripentolThe serum concentration of Abiraterone can be increased when it is combined with Stiripentol.Approved
SulfadiazineThe serum concentration of Sulfadiazine can be increased when it is combined with Abiraterone.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Abiraterone.Approved
SulfamoxoleThe metabolism of Sulfamoxole can be decreased when combined with Abiraterone.Approved
SulfinpyrazoneThe serum concentration of Sulfinpyrazone can be increased when it is combined with Abiraterone.Approved
SulfisoxazoleThe metabolism of Abiraterone can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SuprofenThe metabolism of Suprofen can be decreased when combined with Abiraterone.Approved, Withdrawn
TacrineThe serum concentration of Tacrine can be increased when it is combined with Abiraterone.Withdrawn
TamoxifenThe serum concentration of the active metabolites of Tamoxifen can be reduced when Tamoxifen is used in combination with Abiraterone resulting in a loss in efficacy.Approved
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Abiraterone.Approved, Investigational
TapentadolThe serum concentration of Tapentadol can be increased when it is combined with Abiraterone.Approved
TasimelteonThe serum concentration of Tasimelteon can be increased when it is combined with Abiraterone.Approved
TazaroteneThe serum concentration of Tazarotene can be increased when it is combined with Abiraterone.Approved, Investigational
TegaserodThe serum concentration of Tegaserod can be increased when it is combined with Abiraterone.Investigational, Withdrawn
TelaprevirThe metabolism of Abiraterone can be decreased when combined with Telaprevir.Approved
TelithromycinThe serum concentration of Telithromycin can be increased when it is combined with Abiraterone.Approved
TemafloxacinThe serum concentration of Temafloxacin can be increased when it is combined with Abiraterone.Withdrawn
TemazepamThe serum concentration of Temazepam can be increased when it is combined with Abiraterone.Approved
TeniposideThe metabolism of Teniposide can be decreased when combined with Abiraterone.Approved
TenoxicamThe metabolism of Tenoxicam can be decreased when combined with Abiraterone.Approved
TerbinafineThe serum concentration of Terbinafine can be increased when it is combined with Abiraterone.Approved, Investigational, Vet Approved
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Abiraterone.Withdrawn
TesmilifeneThe serum concentration of Tesmilifene can be increased when it is combined with Abiraterone.Investigational
TestosteroneThe serum concentration of Testosterone can be increased when it is combined with Abiraterone.Approved, Investigational
TetrabenazineThe serum concentration of Tetrabenazine can be increased when it is combined with Abiraterone.Approved
ThalidomideThe serum concentration of Thalidomide can be increased when it is combined with Abiraterone.Approved, Investigational, Withdrawn
TheobromineThe serum concentration of Theobromine can be increased when it is combined with Abiraterone.Approved
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Abiraterone.Approved
ThiabendazoleThe serum concentration of Thiabendazole can be increased when it is combined with Abiraterone.Approved, Vet Approved
ThiamylalThe metabolism of Thiamylal can be decreased when combined with Abiraterone.Approved, Vet Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Abiraterone.Approved
ThiothixeneThe serum concentration of Thiothixene can be increased when it is combined with Abiraterone.Approved
TiclopidineThe serum concentration of Ticlopidine can be increased when it is combined with Abiraterone.Approved
TimololThe serum concentration of Timolol can be increased when it is combined with Abiraterone.Approved
TiotropiumThe serum concentration of Tiotropium can be increased when it is combined with Abiraterone.Approved
TipranavirThe serum concentration of Tipranavir can be increased when it is combined with Abiraterone.Approved, Investigational
TizanidineThe serum concentration of Tizanidine can be increased when it is combined with Abiraterone.Approved
TocilizumabThe serum concentration of Abiraterone can be decreased when it is combined with Tocilizumab.Approved
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Abiraterone.Approved, Investigational
TolbutamideThe serum concentration of Tolbutamide can be increased when it is combined with Abiraterone.Approved
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Abiraterone.Approved, Investigational
TorasemideThe serum concentration of Torasemide can be increased when it is combined with Abiraterone.Approved
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Abiraterone.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Abiraterone.Approved, Investigational
TramadolThe serum concentration of Tramadol can be increased when it is combined with Abiraterone.Approved, Investigational
TrastuzumabTrastuzumab may increase the cardiotoxic activities of Abiraterone.Approved, Investigational
TrazodoneThe serum concentration of Trazodone can be increased when it is combined with Abiraterone.Approved, Investigational
TreprostinilThe metabolism of Treprostinil can be decreased when combined with Abiraterone.Approved, Investigational
TretinoinThe serum concentration of Tretinoin can be increased when it is combined with Abiraterone.Approved, Investigational, Nutraceutical
TriamtereneThe serum concentration of Triamterene can be increased when it is combined with Abiraterone.Approved
TrifluoperazineThe serum concentration of Trifluoperazine can be increased when it is combined with Abiraterone.Approved
TrimethadioneThe serum concentration of Trimethadione can be increased when it is combined with Abiraterone.Approved
TrimethoprimThe serum concentration of Trimethoprim can be increased when it is combined with Abiraterone.Approved, Vet Approved
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Abiraterone.Approved
TroglitazoneThe serum concentration of Troglitazone can be increased when it is combined with Abiraterone.Withdrawn
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Abiraterone.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Abiraterone.Approved
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Abiraterone.Investigational, Withdrawn
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Abiraterone.Approved, Investigational
ValsartanThe metabolism of Valsartan can be decreased when combined with Abiraterone.Approved, Investigational
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Abiraterone.Approved
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Abiraterone.Approved
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Abiraterone.Investigational
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Abiraterone.Approved
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Abiraterone.Approved
VinorelbineThe serum concentration of Vinorelbine can be increased when it is combined with Abiraterone.Approved, Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Abiraterone.Approved
VoriconazoleThe metabolism of Abiraterone can be decreased when combined with Voriconazole.Approved, Investigational
VortioxetineThe serum concentration of Vortioxetine can be increased when it is combined with Abiraterone.Approved
WarfarinThe serum concentration of Warfarin can be increased when it is combined with Abiraterone.Approved
XimelagatranThe metabolism of Ximelagatran can be decreased when combined with Abiraterone.Approved, Investigational, Withdrawn
YohimbineThe serum concentration of Yohimbine can be increased when it is combined with Abiraterone.Approved, Vet Approved
ZafirlukastThe serum concentration of Zafirlukast can be increased when it is combined with Abiraterone.Approved, Investigational
ZalcitabineThe serum concentration of Zalcitabine can be increased when it is combined with Abiraterone.Approved
ZaltoprofenThe metabolism of Zaltoprofen can be decreased when combined with Abiraterone.Approved
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Abiraterone.Approved
ZileutonThe serum concentration of Zileuton can be increased when it is combined with Abiraterone.Approved, Investigational, Withdrawn
ZiprasidoneThe serum concentration of Ziprasidone can be increased when it is combined with Abiraterone.Approved
ZolmitriptanThe serum concentration of Zolmitriptan can be increased when it is combined with Abiraterone.Approved, Investigational
ZolpidemThe serum concentration of Zolpidem can be increased when it is combined with Abiraterone.Approved
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Abiraterone.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Abiraterone.Approved, Investigational
Food Interactions
  • Food and high fat meals increases the drug exposure 4.4-fold. It is suggested that abiraterone is taken on an empty stomach.
References
Synthesis ReferenceNot Available
General References
  1. O'Donnell A, Judson I, Dowsett M, Raynaud F, Dearnaley D, Mason M, Harland S, Robbins A, Halbert G, Nutley B, Jarman M: Hormonal impact of the 17alpha-hydroxylase/C(17,20)-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer. Br J Cancer. 2004 Jun 14;90(12):2317-25. [PubMed:15150570 ]
  2. Ryan CJ, Cheng ML: Abiraterone acetate for the treatment of prostate cancer. Expert Opin Pharmacother. 2013 Jan;14(1):91-6. doi: 10.1517/14656566.2013.745852. Epub 2012 Nov 30. [PubMed:23199349 ]
External Links
ATC CodesL02BX03
AHFS Codes
  • 10:00
PDB EntriesNot Available
FDA labelDownload (418 KB)
MSDSDownload (480 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.98
Caco-2 permeable+0.7245
P-glycoprotein substrateSubstrate0.6583
P-glycoprotein inhibitor IInhibitor0.5
P-glycoprotein inhibitor IINon-inhibitor0.8831
Renal organic cation transporterNon-inhibitor0.7453
CYP450 2C9 substrateNon-substrate0.854
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.6478
CYP450 1A2 substrateInhibitor0.5124
CYP450 2C9 inhibitorNon-inhibitor0.8046
CYP450 2D6 inhibitorNon-inhibitor0.8693
CYP450 2C19 inhibitorNon-inhibitor0.5349
CYP450 3A4 inhibitorInhibitor0.7176
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.5363
Ames testNon AMES toxic0.8499
CarcinogenicityNon-carcinogens0.9616
BiodegradationNot ready biodegradable0.9565
Rat acute toxicity2.4407 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8318
hERG inhibition (predictor II)Non-inhibitor0.7059
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
TabletOral250 mg
TabletOral250 mg/1
TabletOral500 mg
PricesNot Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5604213 No1996-12-132016-12-13Us
US8822438 No2007-08-242027-08-24Us
Properties
StateSolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.00305 mg/mLALOGPS
logP5.1ALOGPS
logP3.97ChemAxon
logS-5.1ALOGPS
pKa (Strongest Acidic)18.2ChemAxon
pKa (Strongest Basic)4.81ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area33.12 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity107.3 m3·mol-1ChemAxon
Polarizability42.04 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as androgens and derivatives. These are 3-hydroxylated C19 steroid hormones. They are known to favor the development of masculine characteristics. They also show profound effects on scalp and body hair in humans.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassAndrostane steroids
Direct ParentAndrogens and derivatives
Alternative Parents
Substituents
  • Androgen-skeleton
  • 3-beta-hydroxysteroid
  • 3-beta-hydroxy-delta-5-steroid
  • Hydroxysteroid
  • 3-hydroxysteroid
  • 3-hydroxy-delta-5-steroid
  • Delta-5-steroid
  • Pyridine
  • Heteroaromatic compound
  • Cyclic alcohol
  • Secondary alcohol
  • Azacycle
  • Organoheterocyclic compound
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Alcohol
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Steroid 17-alpha-monooxygenase activity
Specific Function:
Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.
Gene Name:
CYP17A1
Uniprot ID:
P05093
Molecular Weight:
57369.995 Da
References
  1. Vogiatzi P, Claudio PP: Efficacy of abiraterone acetate in post-docetaxel castration-resistant prostate cancer. Expert Rev Anticancer Ther. 2010 Jul;10(7):1027-30. doi: 10.1586/era.10.84. [PubMed:20645691 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Beckett RD, Rodeffer KM, Snodgrass R: Abiraterone for the treatment of metastatic castrate-resistant prostate cancer. Ann Pharmacother. 2012 Jul-Aug;46(7-8):1016-24. doi: 10.1345/aph.1Q758. Epub 2012 Jun 19. [PubMed:22714819 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Sulfotransferase activity
Specific Function:
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands.
Gene Name:
SULT2A1
Uniprot ID:
Q06520
Molecular Weight:
33779.57 Da
References
  1. Beckett RD, Rodeffer KM, Snodgrass R: Abiraterone for the treatment of metastatic castrate-resistant prostate cancer. Ann Pharmacother. 2012 Jul-Aug;46(7-8):1016-24. doi: 10.1345/aph.1Q758. Epub 2012 Jun 19. [PubMed:22714819 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Chi KN, Tolcher A, Lee P, Rosen PJ, Kollmannsberger CK, Papadopoulos KP, Patnaik A, Molina A, Jiao J, Pankras C, Kaiser B, Bernard A, Tran N, Acharya M: Effect of abiraterone acetate plus prednisone on the pharmacokinetics of dextromethorphan and theophylline in patients with metastatic castration-resistant prostate cancer. Cancer Chemother Pharmacol. 2013 Jan;71(1):237-44. doi: 10.1007/s00280-012-2001-0. Epub 2012 Oct 12. [PubMed:23064959 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da

Carriers

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Toxic substance binding
Specific Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Gene Name:
ALB
Uniprot ID:
P02768
Molecular Weight:
69365.94 Da
References
  1. Ryan CJ, Cheng ML: Abiraterone acetate for the treatment of prostate cancer. Expert Opin Pharmacother. 2013 Jan;14(1):91-6. doi: 10.1517/14656566.2013.745852. Epub 2012 Nov 30. [PubMed:23199349 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Not Available
Specific Function:
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
Gene Name:
ORM1
Uniprot ID:
P02763
Molecular Weight:
23511.38 Da
References
  1. Ryan CJ, Cheng ML: Abiraterone acetate for the treatment of prostate cancer. Expert Opin Pharmacother. 2013 Jan;14(1):91-6. doi: 10.1517/14656566.2013.745852. Epub 2012 Nov 30. [PubMed:23199349 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Transporter activity
Specific Function:
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
Gene Name:
ABCC1
Uniprot ID:
P33527
Molecular Weight:
171589.5 Da
References
  1. Beckett RD, Rodeffer KM, Snodgrass R: Abiraterone for the treatment of metastatic castrate-resistant prostate cancer. Ann Pharmacother. 2012 Jul-Aug;46(7-8):1016-24. doi: 10.1345/aph.1Q758. Epub 2012 Jun 19. [PubMed:22714819 ]
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Drug created on November 18, 2007 11:28 / Updated on December 06, 2016 15:14