Hydrocarbons, Halogenated

Name
Hydrocarbons, Halogenated
Accession Number
DBCAT000682
Description

Hydrocarbon compounds with one or more HYDROGEN atoms substituted with HALOGENS.

ATC Classification
Drugs
DrugDrug Description
HalothaneA general inhalation anesthetic used for the induction and maintenance of general anesthesia.
ChloroformChloroform is an organic small molecule, member of the family of the chloromethanes that presents a formula of CHCl3. It is a colorless, sweet-smelling, dense liquid that is produced on...
TrichloroethyleneTrichloroethylene is a halocarbon commonly used as an industrial solvent, not to be confused with the similar 1,1,1-trichloroethane, also known as chlorothene. It has been sold under a variety of...
ChlorambucilA chemotherapy agent used in the management of chronic lymphocytic leukemia and malignant lymphomas.
LindaneAn ectoparasiticide and ovicide used in the treatment of Pediculosis humanis capitis (head lice) and Phthirus pubis (crab lice).
CyclophosphamideA nitrogen mustard used to treat lymphomas, myelomas, leukemia, mycosis fungoides, neuroblastoma, ovarian adenocarcinoma, retinoblastoma, and breast carcinoma.
PerflutrenA diagnostic medication to improve contrast during echocardiograms.
MitotaneAn adrenal cortex inhibitor used to treat adrenocortical tumors and Cushing's syndrome.
HexachloropheneA chlorinated bisphenol antiseptic used as a surgical scrub and skin cleanser.
Uracil mustardUsed for its antineoplastic properties.
MechlorethamineAn antineoplastic agent used to treat Hodgkin's disease, lymphosarcoma, and chronic myelocytic or lymphocytic leukemia.
BromfenacAn NSAID used to treat postoperative pain and inflammation of the eye.
MelphalanAn alkylating antineoplastic agent used to treat multiple myeloma and ovarian carcinoma.
RosuvastatinAn HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.
IfosfamideAn alkylating and immunosuppressive agent used in chemotherapy for the treatment of cancers, including testicular cancer, ovarian cancer, cervical cancer, osteocarcinoma, bladder cancer, small cell lung cancer, and non-Hodgkin's lymphoma.
IophendylateIophendylate is used as a contrast agent to locate spinal tumors.
EstramustineAn antineoplastic agent used for the management of metastatic and/or progressive prostate cancer in palliative setting.
3-ChlorophenolNot Available
IDD552Not Available
Hexafluoroacetone HydrateNot Available
p-IodophenolNot Available
BromoformNot Available
2-ChlorophenolNot Available
Ethylene DichlorideNot Available
PalifosfamideInvestigated for use/treatment in cancer/tumors (unspecified), lymphoma (unspecified), and sarcoma.
Iodofiltic acid I-123Investigated for use/treatment in cardiac ischemia.
PerflubronInvestigated for use/treatment in cardiac surgery, hemorrhage, and ileus.
PR-104Investigated for use/treatment in cancer/tumors (unspecified) and solid tumors.
PX-478Investigated for use/treatment in cancer/tumors (unspecified).
EvofosfamideInvestigated for use/treatment in solid tumors.
GlufosfamideInvestigated for use/treatment in pancreatic cancer, solid tumors, breast cancer, colorectal cancer, brain cancer, lung cancer, ovarian cancer, and sarcoma.
PriralfinamideInvestigated for use/treatment in pain (acute or chronic).
IobenguaneA radiopharmaceutical agent used for the diagnosis of primary and metastatic pheochromocytoma or neuroblastoma.
BendamustineAn antineoplastic agent used for the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed following rituximab therapy.
TO-901317TO-901317 is an LXRalpha and LXRbeta agonist.
Dichloroacetic acidDichloroacetic acid, often abbreviated DCA, is an acid analogue of acetic acid in which two of the three hydrogen atoms of the methyl group have been replaced by chlorine atoms....
Iopanoic acidIopanoic acid contains iodine and is useful as a contrast medium in cholecystography.
VilanterolA long-acting beta2-adrenergic agonist used in combination with other bronchodilators for the management of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema.
Iopodic acidAn iodine containing cholecystography agent.
Iocetamic acidIocetamic acid is a diagnostic aid (radiopaque medium)
PerflexaneNot Annotated
TrichloroacetateTrichloroacetate, or trichloroacetic acid, is a strong acid prepared by the reaction of chlorine with acetic acid in the presence of a suitable catalyst. In clinical chemistry and biochemistry, it...
DichlorophenDichlorophen is an antimicrobial agent shown to exert activity against cestodes, protozoa, fungi, and bacteria. It is often combined with toluene to remove parasites including ascarids, tapeworm, and hookworm from...
PerflenapentDodecafluoropentane is an ingredient in the EMA-withdrawn product EchoGen.
DinitrochlorobenzeneDinitrochlorobenzene has been used in trials studying the treatment of HIV Infections.
VestipitantVestipitant has been investigated for the treatment of Tinnitus.
MafosfamideMafosfamide has been used in trials studying the treatment of Lymphoma, Leukemia, Meningeal Neoplasm, and Brain and Central Nervous System Tumors.
MitomethMitometh is under investigation for the treatment of Adenocarcinoma, Oropharyngeal Neoplasms, Nasopharyngeal Carcinoma, Non-small Cell Lung Cancer, and Stage IV Non-small Cell Lung Cancer, among others. Mitometh has been investigated...
PerfosfamidePerfosfamide has been used in trials studying the treatment of Lymphoma, Neuroblastoma, and Multiple Myeloma and Plasma Cell Neoplasm.
PerflubutanePerflubutane has been used in trials studying the diagnostic of Liver Mass, Liver Diseases, Liver Metastasis, Portal Hypertension, and Peripheral Artery Disease. It is a cardiovascular drug designed to enable...
PrednimustinePrednimustine has been used in trials studying the treatment of Lymphoma.
TetrasulTetrasul has been used in trials studying the treatment of Erythematous (Type One) Rosacea.
TrofosfamideTrofosfamide has been used in trials studying the treatment of Ependymomas, Medulloblastomas, Sarcoma, Soft Tissue, Supratentorial PNETs, and Recurrent Brain Tumors.
NorfluraneNorflurane is under investigation in clinical trial NCT01673061 (Vapocoolant Spray for Numbing Small Boils Before Incision and Drainage).
PentafluoropropanePentafluoropropane is under investigation in clinical trial NCT01673061 (Vapocoolant Spray for Numbing Small Boils Before Incision and Drainage).
ParachlorophenolAn antibacterial agent used to prevent infections in root canals.
Ethyl chlorideEthyl chloride, or chloroethane, has a chemical formula C2H5Cl. It was commonly used in the production of tetraethyllead (TEL), which is an additive for gasoline. It was also used in...
ClofenotaneNot Annotated
IodoformNo approved therapeutic indications.
1,2-dichlorobenzene1,2-Dichlorobenzene, also named ortho-dichlorobenzene, is an organic compound. It is a non-polar colorless liquid that is miscible in most organic solvents. This derivative of benzene differs from the parent compound...
MRK-409MRK-409 is a GABA-A receptor agonist .
IsofluraneAn inhaled general anesthetic used in surgery.
DesfluraneA general inhalation anesthetic for inpatient and outpatient surgery in adults.
SevofluraneA inhalation anaesthetic agent used for induction and maintenance of general anesthesia during surgical procedures.
Quinacrine mustardNot Available
ElagolixA gonadotropin releasing hormone receptor antagonist used to treat moderate to severe pain in endometriosis.
EplivanserinEplivanserin has been used in trials studying the treatment of Sleep, Insomnia, Chronic Pain, Fibromyalgia, and Primary Insomnia, among others.
TransfluthrinTransfluthrin is under investigation in clinical trial NCT02394522 (Spatial Repellent Products for Control of Vector Borne Diseases - Malaria - Zambia (SR-M-ZM)).
ButafenacilButafenacil is under investigation in clinical trial NCT03760328 (Effect of Upper Airway Stimulation in Patients With Obstructive Sleep Apnea).
Perfluoro tert-butylcyclohexaneOxycyte has been used in trials studying the treatment of Traumatic Brain Injury.
RocacetrapibRocacetrapib is under investigation in clinical trial NCT02156544 (Study to Investigate the Safety/Tolerability and Pharmacokinetics/Pharmacodynamics of CKD-519).
TallimustineAn alkylating agent previously investigated for it's antitumor activity but was stopped due to severe myelotoxicity.
IodobenzeneNot Available
1,3,5-trichlorobenzeneNot Available
Drugs & Drug Targets
DrugTargetType
HalothaneGamma-aminobutyric acid receptor subunit alpha-1target
HalothaneGlycine receptor subunit alpha-1target
HalothaneCalcium-activated potassium channel subunit alpha-1target
HalothaneNADH-ubiquinone oxidoreductase chain 1target
HalothaneIntermediate conductance calcium-activated potassium channel protein 4target
HalothaneRhodopsintarget
HalothaneG protein-activated inward rectifier potassium channel 2target
HalothaneG protein-activated inward rectifier potassium channel 1target
HalothaneGuanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2target
HalothaneNeuropeptide S receptortarget
HalothaneCytochrome P450 2E1enzyme
HalothaneCytochrome P450 2A6enzyme
HalothaneCytochrome P450 3A4enzyme
HalothaneGlutamate receptor ionotropic, NMDA 3Atarget
HalothaneGlutamate receptor ionotropic, NMDA 3Btarget
HalothaneGlutamate receptor ionotropic, NMDA 2Atarget
HalothanePotassium channel subfamily K member 3target
HalothanePotassium channel subfamily K member 9target
HalothaneSerum albumincarrier
HalothaneCytochrome P450 2B6enzyme
HalothaneCytochrome P450 2C9enzyme
HalothaneGABA(A) Receptortarget
HalothanePlasma membrane calcium-transporting ATPasetarget
ChlorambucilDNAtarget
ChlorambucilGlutathione S-transferase Penzyme
ChlorambucilSolute carrier organic anion transporter family member 1A2transporter
LindaneGamma-aminobutyric acid receptor subunit beta-1target
LindaneGlycine receptor subunit alpha-1target
LindaneGlycine receptor subunit alpha-2target
LindaneGlycine receptor subunit alpha-3target
LindaneGlycine receptor subunit betatarget
LindaneGamma-aminobutyric acid receptor subunit beta-3target
LindaneGamma-aminobutyric acid receptor subunit rho-1target
LindaneProgesterone receptortarget
LindaneEstrogen receptor alphatarget
LindaneNuclear receptor subfamily 1 group I member 2target
CyclophosphamideDNAtarget
CyclophosphamideCytochrome P450 2B6enzyme
CyclophosphamideCytochrome P450 2C9enzyme
CyclophosphamideCytochrome P450 3A4enzyme
CyclophosphamideCytochrome P450 2C19enzyme
CyclophosphamideCytochrome P450 2A6enzyme
CyclophosphamideCytochrome P450 2C18enzyme
CyclophosphamideCytochrome P450 2C8enzyme
CyclophosphamideCytochrome P450 3A5enzyme
CyclophosphamideNuclear receptor subfamily 1 group I member 2target
MitotaneCytochrome P450 11B1, mitochondrialtarget
MitotaneAdrenodoxin, mitochondrialtarget
MitotaneSex hormone-binding globulincarrier
MitotaneCorticosteroid-binding globulincarrier
MitotaneCytochrome P450 3A4enzyme
MitotaneEstrogen receptor alphatarget
MitotaneProgesterone receptortarget
MitotaneAndrogen receptortarget
MitotaneThyroxine-binding globulincarrier
MitotaneP-glycoprotein 1transporter
HexachloropheneD-lactate dehydrogenasetarget
HexachloropheneGlutamate dehydrogenase 1, mitochondrialtarget
HexachloropheneSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrialtarget
HexachloropheneEstrogen receptor alphatarget
Uracil mustardDNAtarget
MechlorethamineDNAtarget
MechlorethamineCholinesteraseenzyme
BromfenacProstaglandin G/H synthase 1target
BromfenacProstaglandin G/H synthase 2target
BromfenacProstaglandin G/H synthase 2enzyme
MelphalanDNAtarget
MelphalanSolute carrier family 22 member 3transporter
MelphalanLarge neutral amino acids transporter small subunit 1transporter
Rosuvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
RosuvastatinCytochrome P450 2C9enzyme
RosuvastatinMultidrug resistance-associated protein 4transporter
RosuvastatinSolute carrier organic anion transporter family member 1A2transporter
RosuvastatinSolute carrier organic anion transporter family member 1B3transporter
RosuvastatinSolute carrier organic anion transporter family member 2B1transporter
RosuvastatinCystine/glutamate transportertransporter
RosuvastatinSolute carrier organic anion transporter family member 1B1transporter
RosuvastatinBile salt export pumptransporter
RosuvastatinATP-binding cassette sub-family G member 2transporter
RosuvastatinSerum albumincarrier
RosuvastatinCanalicular multispecific organic anion transporter 1transporter
RosuvastatinSolute carrier family 22 member 8transporter
RosuvastatinSodium/bile acid cotransportertransporter
RosuvastatinIntegrin alpha-Ltarget
IfosfamideCytochrome P450 2B6enzyme
IfosfamideDNAtarget
IfosfamideCytochrome P450 3A4enzyme
IfosfamideCytochrome P450 3A5enzyme
IfosfamideCytochrome P450 2C9enzyme
IfosfamideCytochrome P450 2C8enzyme
IfosfamideCytochrome P450 2A6enzyme
IfosfamideCytochrome P450 2C19enzyme
IfosfamideCytochrome P450 2C18enzyme
IfosfamideProstaglandin G/H synthase 1enzyme
IfosfamideNuclear receptor subfamily 1 group I member 2target
EstramustineEstrogen receptor betatarget
EstramustineEstrogen receptor alphatarget
EstramustineMicrotubule-associated protein 2target
EstramustineMicrotubule-associated protein 1Atarget
EstramustineP-glycoprotein 1transporter
EstramustineCytochrome P450 3A4enzyme
3-ChlorophenolLysozymetarget
IDD552Aldose reductasetarget
2-ChlorophenolMitogen-activated protein kinase 14target
Ethylene DichlorideHaloalkane dehalogenasetarget
PalifosfamideDNA (cytosine-5)-methyltransferase 1target
PR-104Tumor necrosis factortarget
PX-478Hypoxia-inducible factor 1-alphatarget
IobenguaneSodium-dependent noradrenaline transportertransporter
BendamustineCytochrome P450 1A2enzyme
TO-901317Oxysterols receptor LXR-betatarget
TO-901317Nuclear receptor coactivator 2target
TO-901317Retinoic acid receptor RXR-betatarget
TO-901317Oxysterols receptor LXR-alphatarget
TO-901317Nuclear receptor coactivator 1target
TO-901317Nuclear receptor subfamily 1 group I member 2target
Dichloroacetic acid[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrialtarget
Dichloroacetic acidMaleylacetoacetate isomerasetarget
VilanterolCytochrome P450 3A4enzyme
VilanterolBeta-2 adrenergic receptortarget
Iopodic acidThyroxine 5-deiodinasetarget
Iopodic acidSerum albumincarrier
DinitrochlorobenzeneMethylated-DNA--protein-cysteine methyltransferasetarget
DinitrochlorobenzeneGlutathione S-transferase Ptarget
VestipitantNeurokinin 1 receptortarget
ParachlorophenolSolute carrier organic anion transporter family member 1B3transporter
ParachlorophenolSodium channel protein type 4 subunit alphatarget
1,2-dichlorobenzeneCytochrome P450 2E1enzyme
IsofluraneCalcium-transporting ATPase type 2C member 1target
IsofluraneATP synthase subunit delta, mitochondrialtarget
IsofluraneGamma-aminobutyric acid receptor subunit alpha-1target
IsofluranePotassium voltage-gated channel subfamily A member 1target
IsofluraneGlutamate receptor 1target
IsofluraneGlycine receptor subunit alpha-1target
IsofluraneCalmodulintarget
IsofluraneCytochrome P450 2E1enzyme
IsofluraneSerum albumincarrier
IsofluraneCytochrome P450 2B6enzyme
IsofluraneNADH-ubiquinone oxidoreductase chain 1enzyme
IsofluraneGABA(A) Receptortarget
IsofluraneNeuronal acetylcholine receptor subunit alpha-4target
IsofluraneNeuronal acetylcholine receptor subunit beta-2target
DesfluraneNADH-ubiquinone oxidoreductase chain 1target
DesfluraneGlycine receptor subunit alpha-1target
DesfluraneGlutamate receptor 1target
DesfluraneGABA(A) Receptortarget
DesfluranePotassium voltage-gated channel subfamily A member 1target
DesfluraneATP synthase subunit delta, mitochondrialtarget
DesfluraneSerum albumincarrier
DesfluraneCalcium transporting ATPasestarget
SevofluraneCalcium-transporting ATPase type 2C member 1target
SevofluraneNADH-ubiquinone oxidoreductase chain 1target
SevofluraneGlycine receptor subunit alpha-1target
SevofluraneGlutamate receptor 1target
SevofluraneGamma-aminobutyric acid receptor subunit alpha-1target
SevofluraneCytochrome P450 2E1enzyme
SevofluraneSerum albumincarrier
SevofluraneCytochrome P450 2A6enzyme
SevofluraneCytochrome P450 2B6enzyme
SevofluraneCytochrome P450 3A4enzyme
SevofluraneGABA(A) Receptortarget
SevofluraneMitochondrial potassium channeltarget
Quinacrine mustardTrypanothione reductasetarget
ElagolixGonadotropin-releasing hormone receptortarget
ElagolixCytochrome P450 3A Subfamilyenzyme
ElagolixCytochrome P450 2D6enzyme
ElagolixCytochrome P450 2C8enzyme
ElagolixP-glycoprotein 1transporter
ElagolixSolute carrier organic anion transporter family member 1B1transporter
Eplivanserin5-hydroxytryptamine receptor 2Atarget
Eplivanserin5-hydroxytryptamine receptor 2Ctarget
TallimustineDNAtarget
IodobenzeneEndoglucanase Ftarget
1,3,5-trichlorobenzeneCamphor 5-monooxygenasetarget