|Accession Number||DB00923 (APRD00853)|
Ceforanide is a second-generation parenteral cephalosporin antibiotic. It has a longer elimination half-life than any currently available cephalosporin. Its activity is very similar to that of cefamandole, a second-generation cephalosporin, except that ceforanide is less active against most gram-positive organisms. Many coliforms, including Escherichia coli, Klebsiella, Enterobacter, and Proteus, are susceptible to ceforanide, as are most strains of Salmonella, Shigella, Hemophilus, Citrobacter and Arizona species.
|Product Ingredients||Not Available|
|Approved Prescription Products||Not Available|
|Approved Generic Prescription Products||Not Available|
|Approved Over the Counter Products||Not Available|
|Unapproved/Other Products||Not Available|
|Brand mixtures||Not Available|
|Weight||Average: 519.554 |
For the treatment of infections caused by susceptible organisms.
|Structured Indications||Not Available|
Ceforanide is a semisynthetic second-generation cephalosporin. The cephalosporins are bactericidal drugs with both gram-positive and gram-negative activity. They inhibit bacterial cell wall synthesis in a way similar to the penicillins.
|Mechanism of action|
The bactericidal activity of ceforanide results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs).
Rapidly absorbed following intramuscular injection.
|Volume of distribution||Not Available|
The major drug elimination route was urinary excretion with 85% of the dose being excreted unchanged in the urine within 12 hr, and no metabolites with antibiotic activity were observed in urine.
|Route of elimination||Not Available|
2.6 to 2.98 hours
Adverse effects following overdosage include nausea, vomiting, epigastric distress, diarrhea, and convulsions.
|Pharmacogenomic Effects/ADRs||Not Available|
|Food Interactions||Not Available|
|Synthesis Reference||Not Available|
|ATC Codes||J01DC11 — Ceforanide|
|AHFS Codes||Not Available|
|PDB Entries||Not Available|
|FDA label||Not Available|
|Clinical Trials||Not Available|
|Dosage forms||Not Available|
|Predicted ADMET features|
|Mass Spec (NIST)||Not Available|
|Description||This compound belongs to the class of organic compounds known as cephalosporins. These are compounds containing a 1,2-thiazine fused to a 2-azetidinone to for a oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid moiety or a derivative thereof.|
|Super Class||Organoheterocyclic compounds|
|Sub Class||Beta lactams|
|Alternative Parents||N-acyl-alpha amino acids and derivatives / Phenylacetamides / Benzylamines / Phenylmethylamines / Alkylarylthioethers / Aralkylamines / 1,3-thiazines / Dicarboxylic acids and derivatives / Tertiary carboxylic acid amides / Tetrazoles / Heteroaromatic compounds / Secondary carboxylic acid amides / Amino acids / Azetidines / Dialkylthioethers / Carboxylic acids / Sulfenyl compounds / Azacyclic compounds / Thiohemiaminal derivatives / Carbonyl compounds / Organic oxides / Organopnictogen compounds / Monoalkylamines / Hydrocarbon derivatives|
|Substituents||Cephalosporin / N-acyl-alpha amino acid or derivatives / Alpha-amino acid or derivatives / Phenylacetamide / Phenylmethylamine / Aryl thioether / Benzylamine / Alkylarylthioether / Aralkylamine / Meta-thiazine/ Benzenoid / Monocyclic benzene moiety / Dicarboxylic acid or derivatives / Tertiary carboxylic acid amide / Tetrazole / Heteroaromatic compound / Azole / Amino acid or derivatives / Azetidine / Amino acid / Carboxamide group / Secondary carboxylic acid amide / Thioether / Hemithioaminal / Sulfenyl compound / Dialkylthioether / Carboxylic acid derivative / Azacycle / Carboxylic acid / Organosulfur compound / Hydrocarbon derivative / Primary aliphatic amine / Organic nitrogen compound / Carbonyl group / Amine / Organic oxide / Organopnictogen compound / Organic oxygen compound / Organonitrogen compound / Primary amine / Organooxygen compound / Aromatic heteropolycyclic compound|
|Molecular Framework||Aromatic heteropolycyclic compounds|
|External Descriptors||cephalosporin (CHEBI:3495 )|
- Bacteroides fragilis
- Pharmacological action
- General Function:
- Penicillin binding
- Specific Function:
- Not Available
- Gene Name:
- Uniprot ID:
- Molecular Weight:
- 69434.305 Da
- Barriere SL, Mills J: Ceforanide: antibacterial activity, pharmacology, and clinical efficacy. Pharmacotherapy. 1982 Nov-Dec;2(6):322-7. [PubMed:6762529 ]
- Yotsuji A, Mitsuyama J, Hori R, Yasuda T, Saikawa I, Inoue M, Mitsuhashi S: Mechanism of action of cephalosporins and resistance caused by decreased affinity for penicillin-binding proteins in Bacteroides fragilis. Antimicrob Agents Chemother. 1988 Dec;32(12):1848-53. [PubMed:3266730 ]