Nephrotoxic agents

This category includes all drugs with the potential to generate kidney damage and to reduce renal function.
DrugDrug NameDrug Indication
DB00681Amphotericin BUsed to treat potentially life threatening fungal infections.
DB00515CisplatinFor the treatment of metastatic testicular tumors, metastatic ovarian tumors and advanced bladder cancer.
DB01111ColistimethateFor the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly _Pseudomonas aeruginosa_.
DB00529FoscarnetFor the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) and for treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients.
DB00742MannitolUsed for the promotion of diuresis before irreversible renal failure becomes established, the reduction of intracranial pressure, the treatment of cerebral edema, and the promotion of urinary excretion of toxic substances.
DB00512VancomycinA variety of dosage forms (for example, oral, injections, etc.) exist for the treatment of serious or severe infections caused by susceptible strains of methicillin-resistant (beta-lactam-resistant) staphylococci [FDA Label]. Additionally, a unique FDA approved oral liquid treatment is also available and indicated for the treatment of Clostridium difficile associated diarrhea and enterocolitis caused by _Staphylococcus aureus_, including methicillin-resistant strains [L1196].
DB00091CyclosporineFor treatment of transplant (kidney, liver, and heart) rejection, rheumatoid arthritis, severe psoriasis.
DB00229CefotiamFor treatment of severe infections caused by susceptible bacteria.
DB00274CefmetazoleFor the treatment of infections caused by susceptible organisms.
DB00447LoracarbefUsed to treat upper respiratory tract bacterial infections, chronic bronchitis, pneumonia, sinusitis, pharyntitis and tonsillitis, skin absceses, urinary tract infections and pyelonephritis caused by E. coli, S. pyogenes, S. aureus, S. saprphyticus, S. penumoniae, H. influenzae and M. catarrhalis.
DB00833CefaclorFor the treatment of certain infections caused by bacteria such as pneumonia and ear, lung, skin, throat, and urinary tract infections.
DB00923CeforanideFor the treatment of infections caused by susceptible organisms.
DB01150CefprozilFor the treatment of the following infections (respiratory, skin, soft tissue, UTI, ENT) caused by; S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph
DB01326CefamandoleFor the treatment of serious infections caused by susceptible strains of microorganisms.
DB01328CefonicidFor the treatment of bacterial infections caused by susceptible microorganisms.
DB01330CefotetanFor prophylaxis and treatment of bacterial infections.
DB01331CefoxitinFor the treatment of serious infections caused by susceptible strains microorganisms.
DB09062CefminoxNot Available
DB11935FlomoxefNot Available
DB01112CefuroximeFor the treatment of many different types of bacterial infections such as bronchitis, sinusitis, tonsillitis, ear infections, skin infections, gonorrhea, and urinary tract infections.
DB00267CefmenoximeUsed to treat female gynecologic and obstetric infections caused by susceptible aerobic (including the gonococcus) and anaerobic bacteria.
DB00430CefpiramideFor treatment of severe infections caused by susceptible bacteria such as P. aeruginosa.
DB00438CeftazidimeFor the treatment of patients with infections caused by susceptible strains of organisms in the following diseases: lower respiratory tract infections,skin and skin structure infections, urinary tract infections, bacterial septicemia, bone and joint infections, gynecologic infections, intra abdominal infections (including peritonitis), and central nervous system infections (including meningitis).
DB00493CefotaximeUsed to treat gonorrhoea, meningitis, and severe infections including infections of the kidney (pyelonephritis) and urinary system. Also used before an operation to prevent infection after surgery.
DB01066CefditorenFor the treatment of mild to moderate infections in adults and adolescents (12 years of age or older) which are caused by susceptible strains of microorganisms in acute bacterial exacerbation of chronic bronchitis, community-acquired pneumonia, pharyngitis/tonsillitis, and uncomplicated skin and skin-structure infections.
DB01212CeftriaxoneFor the treatment of the infections (respiratory, skin, soft tissue, UTI, ENT) caused by S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph
DB01329CefoperazoneFor the treatment of bacterial infections caused by susceptible microorganisms.
DB01332CeftizoximeFor the treatment of infections due to susceptible strains of microorganisms.
DB01415CeftibutenUsed to treat acute bacterial exacerbations of chronic bronchitis (ABECB), acute bacterial otitis media, pharyngitis, and tonsilitis.
DB01416CefpodoximeFor the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms.
DB04570LatamoxefLatamoxef is an oxacephem antibiotic usually grouped with the cephalosporins. It is used to treat bacterial infections. Latamoxef is primarily indicated in conditions like Bone and joint infection, GI infections, Gynecological infections, Meningitis, Respiratory tract infections, Septicaemia, Skin infections, Soft tissue infections, UTI.
DB01413CefepimeFor the treatment of pneumonia (moderate to severe) caused by Streptococcus pneumoniae, including cases associated with concurrent bacteremia, Pseudomonas aeruginosa, Klebsiella pneumoniae, or Enterobacter species. Also for empiric treatment of febrile neutropenic patients and uncomplicated and complicated urinary tract infections (including pyelonephritis) caused by Escherichia coli or Klebsiella pneumoniae, when the infection is severe, or caused by Escherichia coli, Klebsiella pneumoniae, or Proteus mirabilis, when the infection is mild to moderate, including cases associated with concurrent bacteremia with these microorganisms. Also for the treatment of uncomplicated skin and skin structure infections caused by Staphylococcus aureus (methicillin-susceptible strains only) or Streptococcus pyogenes and complicated intra-abdominal infections (used in combination with metronidazole) caused by Escherichia coli, viridans group streptococci, Pseudomonas aeruginosa, Klebsiella pneumoniae, Enterobacter species, or Bacteroides fragilis.
DB13667CefozopranNot Available
DB13682CefpiromeNot Available
DB00479AmikacinThe amikacin sulfate injection is indicated in the short-term treatment of serious bacterial infections due to susceptible strains of gram-negative bacteria, including Pseudomonas species, Escherichia coli, species of indole-positive and indole-negative Proteus, Providencia species, Klebsiella-Enterobacter-Serratia species, as well as Acinetobacter (Mima-Herellea) species [F1954]. Clinical studies have shown amikacin sulfate injection to be effective in bacterial septicemia (including neonatal sepsis); in serious infections of the respiratory tract, bones and joints, central nervous system (including meningitis) and skin and soft tissue; intra-abdominal infections (including peritonitis); and in burns and postoperative infections (including post-vascular surgery) [F1954]. Clinical studies have shown amikacin also to be effective in serious, complicated, and recurrent urinary tract infections due to the above organisms. Aminoglycosides, including amikacin, are not indicated in uncomplicated first-time episodes of urinary tract infections unless the causative organisms are not susceptible to antibiotics which are less toxic [F1954]. In September 2018, a new indication with a new dosage route was approved for this drug. Amikacin liposome inhalation suspension was approved for the treatment of lung disease caused by a group of bacteria, Mycobacterium avium complex (MAC) in a limited population of patients with the disease who do not respond to conventional treatment (refractory disease) [L4673]. This indication is approved under accelerated approval based on achieving sputum culture conversion (defined as 3 consecutive negative monthly sputum cultures) by Month 6 of treatment. Clinical benefit has not yet been established [FDA label]. **Important notes regarding Staphylococcus and Sensitivity testing:** Staphylococcus aureus, including methicillin-resistant strains, is the principal Gram-positive organism sensitive to amikacin. The use of amikacin in the treatment of staphylococcal infections should be restricted only to second-line therapy, and should be limited to only those patients suffering from severe infections caused by susceptible strains of staphylococcus species who have failed to show sensitivity to other available antibiotics [F1949]. Bacteriologic studies should be performed to identify causative organisms and their susceptibilities to amikacin. Amikacin may be used as initial therapy in suspected gram-negative infections and therapy may be initiated before obtaining the results of susceptibility testing [FDA label], [F1949], [F1954].
DB00684TobramycinFor the treatment of pseudomonas aeruginosa lung infections. Also being investigated for use in the treatment of sinus infections.
DB00798GentamicinFor treatment of serious infections caused by susceptible strains of the following microorganisms: P. aeruginosa, Proteus species (indole-positive and indole-negative), E. coli, Klebsiella-Enterobactor-Serratia species, Citrobacter species and Staphylococcus species (coagulase-positive and coagulase-negative).
DB00994NeomycinTopical uses include treatment for superficial eye infections caused by susceptible bacteria (used in combination with other antiinfectives), treatment of otitis externa caused by susceptible bacteria, treatment or prevention of bacterial infections in skin lesions, and use as a continuous short-term irrigant or rinse to prevent bacteriuria and gram negative rod bacteremia in abacteriuric patients with indwelling catheters. May be used orally to treat hepatic encephalopathy, as a perioperative prophylactic agent, and as an adjunct to fluid and electrolyte replacement in the treatment of diarrhea caused to enteropathogenic E. coli (EPEC).
DB01082StreptomycinFor the treatment of tuberculosis. May also be used in combination with other drugs to treat tularemia (Francisella tularensis), plague (Yersia pestis), severe M. avium complex, brucellosis, and enterococcal endocarditis (e.g. E. faecalis, E. faecium).
DB00452FramycetinFor the treatment of bacterial blepharitis, bacterial bonjunctivitis, corneal injuries, corneal ulcers and meibomianitis. For the prophylaxis of ocular infections following foreign body removal
DB00955NetilmicinFor the treatment of bacteremia, septicaemia, respiratory tract infections, skin and soft-tissue infection, burns, wounds, and peri-operative infections caused by susceptible strains.
DB01172KanamycinFor treatment of infections where one or more of the following are the known or suspected pathogens: E. coli, Proteus species (both indole-positive and indole-negative), E. aerogenes, K. pneumoniae, S. marcescens, and Acinetobacter species.
DB01421ParomomycinFor the treatment of acute and chronic intestinal amebiasis (it is not effective in extraintestinal amebiasis). Also for the management of hepatic coma as adjunctive therapy.
DB03615RibostamycinNot Available
DB04263GeneticinNot Available
DB04626ApramycinFor the treatment of bacterial infections in animals.
DB04729Gentamicin C1aNot Available
DB04808NeamineNot Available
DB06696ArbekacinArbekacin is used for the short term treatment of multi-resistant bacterial infections, such as methicillin-resistant Staphylococcus aureus (MRSA).
DB08437PuromycinNot Available
DB11512DihydrostreptomycinNot Available
DB12604SisomicinNot Available
DB12615PlazomicinPlazomicin is indicated for the treatment of patients 18 years of age or older with Complicated Urinary Tract Infections (cUTI) including Pyelonephritis, who have limited or no alternative treatment options. It should only be used to treat infections that are proven or strongly suspected to be caused by susceptible microorganisms [FDA Label].
DB00314CapreomycinUsed in the treatment of tuberculosis in combination with other drugs.
DB01050IbuprofenIbuprofen is the most commonly used and prescribed NSAID. It is very common over the counter medication widely used as an analgesic, anti-inflammatory and antipyretic.[A39096] The use of ibuprofen and its enantiomer [DB09213] in a racemic mix is common for the management of mild to moderate pain related to dysmenorrhea, headache, migraine, postoperative dental pain, spondylitis, osteoarthritis, rheumatoid arthritis, and soft tissue disorder.[A39097] Due to its activity against prostaglandin and thromboxane synthesis, ibuprofen has been attributed to alteration of platelet function and prolongation of gestation and labor.[A39092] As ibuprofen is a widely used medication, the main therapeutic indications are: * Patent Ductus Arteriosus - it is a neonatal condition wherein the ductus arteriosus (blood vessel that connects the main pulmonary artery to the proximal descending aorta) fails to close after birth causing severe risk of heart failure. The prostaglandin inhibition of ibuprofen has been studied for the treatment of this condition as it is known that prostaglandin E2 is responsible for keeping the ductus arteriosus open.[A39100] * Rheumatoid- and osteo-arthritis - ibuprofen is very commonly used in the symptomatic treatment of inflammatory, musculoskeletal and rheumatic disorders.[A39176] * Cystic fibrosis - the use of high dosages of ibuprofen has been proven to decrease inflammation and decreasing polymorphonuclear cell influx in the lungs.[A39177] * Orthostatic hypotension - ibuprofen can induce sodium retention and antagonize the effect of diuretics which has been reported to be beneficial for patients with severe orthostatic hypotension.[A1651] * Dental pain - ibuprofen is used to manage acute and chronic orofacial pain.[A10901] * Minor pain - ibuprofen is widely used to reduce minor aches and pains as well as to reduce fever and manage dysmenorrhea. It is very commonly used for the relief of acute indications such as fever and tension headaches.[A39092] * Investigational uses - efforts have been put into developing ibuprofen for the prophylaxis of Alzheimer's disease, Parkinson disease, and breast cancer.[A39092]
DB01250OlsalazineFor the treatment of Inflammatory Bowel Disease and Ulcerative Colitis.
DB03585OxyphenbutazoneNot Available
DB04812BenoxaprofenNot Available
DB04817MetamizoleUsed in the past as a powerful painkiller and fever reducer.
DB04828ZomepiracZomepirac was indicated for the management of mild to severe pain.
DB06737ZaltoprofenNot Available
DB07402AzapropazoneNot Available
DB07477FelbinacNot Available
DB08797SalicylamideNot Available
DB08940KebuzoneNot Available
DB08942IsoxicamNot Available
DB08951IndoprofenNot Available
DB08955IbuproxamNot Available
DB08976FloctafenineNot Available
DB08981FenbufenNot Available
DB08984EtofenamateNot Available
DB08991EpirizoleNot Available
DB09212LoxoprofenLoxoprofen is non-steroidal anti-inflammatory medication (NSAID) indicated for pain and inflammation related to musculoskeletal and joint disorders [L1226]. In addition to its effects on pain, it is an antipyretic and anti-inflammatory medication [L1227].
DB09216Tolfenamic AcidIn the information for tolfenamic acid, it is stated that this drug, being an NSAID, is effective in treating the pain associated with the acute attack of migraines in adults.[L1293]
DB09218ClonixinUsed primarily in the treatment of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation.
DB09288PropacetamolPropacetamol is a paracetamol prodrug of intravenous administration used to control fever and pain of perioperative period in multimodal analgesia therapy.[L1511]
DB12545IndobufenNot Available
DB13001TinoridineNot Available
DB13167AlclofenacAlclofenac is indicated in rheumatology, in particular for the treatment of rheumatoid arthritis, ankylosing spondylitis and, as an analgesic, in painful arthritic pathologies.
DB13217FentiazacNot Available
DB13232SuxibuzoneNot Available
DB13314AlminoprofenNot Available
DB13501BendazacNot Available
DB13514PranoprofenNot Available
DB13538GuacetisalNot Available
DB13612Carbaspirin calciumNot Available
DB13657BenorilateNot Available
DB13783AcemetacinAcemetacin is not FDA, Canada or EMA approved, but in the countries where it is marketed it is indicated for the symptomatic treatment of pain and swelling in acute inflammation of the joints in rheumathoid arthritis, osteoarthritis, low back pain and post-surgical pain.[L1045] It is also indicated for the treatment of chronic inflammation of the joints in presence of rheumatoid arthritis, treatment of ankylosing spondylitis, treatment of irritation in the joints and spinal column caused by degenerative disorders, treatment of inflammatory soft-tissue rheumatism syndrome and painful swelling and inflammation caused by injury.[L1044, L1046]
DB09084BenzydamineAvailable predominantly as a liquid mouthwash, oromucosal spray, or topical cream, benzydamine is most frequently employed as a locally acting analgesic and anti-inflammatory treatment for the relief of painful inflammatory conditions. When formulated as a mouthwash or spray, benzydamine may be used to treat traumatic conditions like pharyngitis following tonsillectomy or the use of a naso-gastric tube, inflammatory conditions like pharyngitis, aphthous ulcers and oral ulceration due to radiation therapy, dentistry operations and procedures, or more general conditions like sore throat, sore tongue, sore gums, mouth ulcers, or discomfort caused by dentures. [L1121] When used as a topical cream, benzydamine may be employed to relieve symptoms associated with painful inflammatory conditions of the muscolo-skeletal system including acute inflammatory disorders such as myalgia and bursitis or traumatic conditions like sprains, strains, bruises, sore muscles, stiff joints, or even the after-effects of fractures. [ L1123]
DB01424AminophenazoneFormerly widely used as an antipyretic and analgesic in rheumatism, neuritis, and common colds. Currently used to measure total body water.
DB14059SC-236Not Available
DB14060NS-398Not Available
DB12445NitroaspirinNot Available
DB09285Morniflumate Morniflumate is indicated for the treatment of inflammatory conditions affecting the airways, ENT system, urogenital tract and bone and joint systems in adults. In Italy, morniflumate is also indicated for the treatment of pain associated with ear, nose, throat (ENT) and gastrointestinal inflammatory conditions in children. Morniflumate is a well established NSAID that has been in use for over three decades in Italy (particularly for the treatment of upper respiratory tract infections in children), France, Belgium, Austria, Switzerland, Spain and Portugal; it has a generally favorable tolerability profile.
DB00533RofecoxibFor the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras.
DB00580ValdecoxibFor the treatment of osteoarthritis and dysmenorrhoea
DB01283LumiracoxibFor the acute and chronic treatment of the signs and symptoms of osteoarthritis of the knee in adults.
DB01628EtoricoxibFor the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, chronic low back pain, acute pain and gout.
DB08439ParecoxibUsed for short term perioperative pain control.
DB00461NabumetoneFor acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis.
DB00482CelecoxibFor the relief and management of osteoarthritis (OA), rheumatoid arthritis (RA), juvenile rheumatoid arthritis (JRA), ankylosing spondylitis, acute pain, primary dysmenorrhea and oral adjunct to usual care for patients with familial adenomatous polyposis [FDA label].
DB00749EtodolacFor acute and long-term management of signs and symptoms of osteoarthritis and rheumatoid arthritis, as well as for the management of pain.
DB11455RobenacoxibNot Available
DB00821CarprofenFor use as a pain reliever in the treatment of joint pain and post-surgical pain.
DB00814MeloxicamFor symptomatic treatment of arthritis and osteoarthritis.
DB00963BromfenacFor the treatment of postoperative inflammation in patients who have undergone cataract extraction.
DB04743NimesulideFor the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.
DB06802NepafenacFor the treatment of pain and inflammation associated with cataract surgery.
DB04552Niflumic AcidUsed in the treatment of rheumatoid arthritis.
DB05095CimicoxibInvestigated for use/treatment in depression.
DB06736Aceclofenac Indicated for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.
DB09217FirocoxibUsed for the treatment of pain inflammation and fever in horses and dogs.
DB09295TalniflumateTalnifumate is a phthalidyl ester of nifumic acid, which has potent analgesic and anti-inflammatory effects and is widely used to treat inflammatory disorders, such as rheumatoid arthritis and osteoarthritis [L1409], and has also been studied for the management of cystic fibrosis [L1403].
DB00244MesalazineFor the treatment of active ulcerative proctitis.
DB00328IndomethacinFor moderate to severe rheumatoid arthritis including acute flares of chronic disease, ankylosing spondylitis, osteoarthritis, acute painful shoulder (bursitis and/or tendinitis) and acute gouty arthritis.
DB00465KetorolacFor the short-term (~5 days) management of moderately severe acute pain that requires analgesia at the opioid level, usually in a postoperative setting.
DB00469TenoxicamFor the treatment of rheumatoid arthritis, osteoarthritis, backache, and pain.
DB00500TolmetinFor the relief of signs and symptoms of rheumatoid arthritis and osteoarthritis, including the treatment of acute flares long-term management. Also for treatment of juvenile rheumatoid arthritis.
DB00554PiroxicamFor treatment of osteoarthritis and rheumatoid arthritis.
DB00573FenoprofenFor relief of the signs and symptoms of rheumatoid arthritis and osteoarthritis. Also for the relief of mild to moderate pain.
DB00788NaproxenFor the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, tendinitis, bursitis, and acute gout. Also for the relief of mild to moderate pain and the treatment of primary dysmenorrhea.
DB00861DiflunisalFor symptomatic treatment of mild to moderate pain accompanied by inflammation (e.g. musculoskeletal trauma, post-dental extraction, post-episiotomy), osteoarthritis, and rheumatoid arthritis.
DB00870SuprofenUsed as eye drops to inhibit the miosis (pupil constriction) that may occur during ocular surgery.
DB00939Meclofenamic acidFor the relief of mild to moderate pain, for the treatment of primary dysmenorrhea and for the treatment of idiopathic heavy menstrual blood loss. Also for relief of the signs and symptoms of acute and chronic rheumatoid arthritis and osteoarthritis.
DB00945Acetylsalicylic acidFor use in the temporary relief of various forms of pain, inflammation associated with various conditions (including rheumatoid arthritis, juvenile rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis, and ankylosing spondylitis), and is also used to reduce the risk of death and/or nonfatal myocardial infarction in patients with a previous infarction or unstable angina pectoris.
DB01009KetoprofenFor symptomatic treatment of acute and chronic rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, primary dysmenorrhea and mild to moderate pain associated with musculotendinous trauma (sprains and strains), postoperative (including dental surgery) or postpartum pain.
DB01014BalsalazideFor the treatment of mildly to moderately active ulcerative colitis.
DB00159IcosapentEPA can be used for lowering elevated triglycerides in those who are hyperglyceridemic. In addition, EPA may play a therapeutic role in patients with cystic fibrosis by reducing disease severity and may play a similar role in type 2 diabetics in slowing the progression of diabetic nephropathy.
DB00712FlurbiprofenFlurbiprofen tablets are indicated for the acute or long-term symptomatic treatment of rheumatoid arthritis, osteorarthritis and anklosing spondylitis. It may also be used to treat pain associated with dysmenorrhea and mild to moderate pain accompanied by inflammation (e.g. bursitis, tendonitis, soft tissue trauma). Topical ophthalmic formulations may be used pre-operatively to prevent intraoperative miosis.
DB00784Mefenamic acidFor the treatment of rheumatoid arthritis, osteoarthritis, dysmenorrhea, and mild to moderate pain, inflammation, and fever.
DB01399SalsalateFor relief of the signs and symptoms of rheumatoid arthritis, osteoarthritis and related rheumatic disorders.
DB00605SulindacFor acute or long-term use in the relief of signs and symptoms of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute painful shoulder (acute subacromial bursitis/supraspinatus tendinitis), and acute gouty arthritis.
DB00936Salicylic acidKey additive in many skin-care products for the treatment of acne, psoriasis, callouses, corns, keratosis pilaris and warts.
DB00991OxaprozinUsed to relieve the inflammation, swelling, stiffness, and joint pain associated with rheumatoid arthritis and osteoarthritis.
DB01600Tiaprofenic acidTiaprofenic acid is used to treat pain, especially arthritic pain.
DB01397Magnesium salicylateMagnesium salicylate is a common analgesic and non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate muscular pain
DB06725LornoxicamFor the treatment of acute mild to moderate pain, as well as pain and inflammation of the joints caused by certain types of rheumatic diseases.
DB00812PhenylbutazoneFor the treatment of backache and ankylosing spondylitis
DB00795SulfasalazineFor the treatment of Crohn's disease and rheumatoid arthritis as a second-line agent.
DB01435AntipyrineAntipyrine is an analgesic often used to test effects of other drugs on liver enzymes..
DB01419AntrafenineAntrafenine is used as an anti-inflammatory and analgesic agent for the relief of mild to moderate pain.
DB01401Choline magnesium trisalicylateCholine magnesium trisalicylate is used to reduce pain and inflammation caused by conditions such as arthritis. This medication is also used to treat fever in adults.
DB09213DexibuprofenFor more information, refer to [ibuprofen].
DB09215DroxicamDroxicam is an NSAID previously used for the treatment of inflammation and rheumatoid arthritis [L1119].
DB11079Trolamine salicylateIndicated for the temporary relief of aches, and pains of muscles and joints associated with backache, lumbago, strains, bruises, sprains and arthritic or rheumatic pain, pain of tendons and ligaments [L1791].
DB13346BufexamacIndicated for the treatment of various skin conditions, such as atopic eczema and other inflammatory dermatoses.
DB09214DexketoprofenFor short-term treatment of mild to moderate pain, including dysmenorrhoea, musculoskeletal pain and toothache [L1302].
DB00586DiclofenacFor the acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis.
DB03450Cephalothin GroupNot Available
DB02247Hydrolyzed CephalothinNot Available
DB00456CefalotinUsed to prevent infection during surgery and to treat many kinds of infections of the blood, bone or joints, respiratory tract, skin, and urinary tract.
DB00738PentamidineFor the treatment of pneumonia due to Pneumocystis carinii.
DB00958CarboplatinFor the initial treatment of advanced ovarian carcinoma in established combination with other approved chemotherapeutic agents. One established combination regimen consists of PARAPLATIN and cyclophosphamide. It is also indicated for the palliative treatment of patients with ovarian carcinoma recurrent after prior chemotherapy, including patients who have been previously treated with cisplatin.
DB09299Tenofovir alafenamideFor use in the treatment of HIV infection and chronic hepatitis B.
DB14126TenofovirNot Available
DB00300Tenofovir disoproxilTenofovir is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and pediatric patients 2 years of age and older. It is also indicated for the treatment of chronic hepatitis B in adults and pediatric patients 12 years of age and older.
DB00567CephalexinFor the treatment of respiratory tract infections caused by Streptococcus pneumoniae and Streptococcus pyogenes; otitis media due to Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and Moraxella catarrhalis; skin and skin structure infections caused by Staphylococcus aureus and/or Streptococcus pyogenes; bone infections caused by Staphylococcus aureus and/or Proteus mirabilis; genitourinary tract infections, including acute prostatitis, caused by Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae.
DB01139CefapirinFor treatment of infections caused by susceptible bacteria.
DB01140CefadroxilFor the treatment of the following infections (skin, UTI, ENT) caused by; S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staphylococci and Streptococcus pyogenes
DB01327CefazolinMainly used to treat bacterial infections of the skin. It can also be used to treat moderately severe bacterial infections involving the lung, bone, joint, stomach, blood, heart valve, and urinary tract. It is clinically effective against infections caused by staphylococci and streptococci species of Gram positive bacteria. May be used for surgical prophylaxis; if required metronidazole may be added to cover B. fragilis.
DB01333CefradineNot Available
DB01414CefacetrileCefacetrile is a broad-spectrum first generation cephalosporin antibiotic effective in Gram-positive and Gram-negative bacterial infections.
DB09008CephaloridineNot Available
DB11367CefroxadineWas used for the treatment of bacterial infections.
DB13266CefatrizineNot Available
DB00689CephaloglycinFor treatment of severe infections caused by susceptible bacteria.
DB06590Ceftaroline fosamilCeftaroline fosamil is indicated for the treatment of patients with the following infections caused by susceptible isolates of the designated microorganisms.
DB04918CeftobiproleFor the treatment of serious bacterial infections in hospitalised patients.
DB00626BacitracinFor the treatment of infants with pneumonia and empyema caused by staphylococci shown to be susceptible to the drug. Also used in ointment form for topical treatment of a variety of localized skin and eye infections, as well as for the prevention of wound infections. Used against gram positive bacteria. Bacitracin is also used as an inhibitor of proteases and other enzymes. However, specific activity of bactracin's inhibition of protein disulfide isomerase has been called into question.
DB00787AcyclovirFor the treatment and management of herpes zoster (shingles), genital herpes, and chickenpox.
DB00577ValaciclovirFor the treatment or suppression of cold sores (herpes labialis), herpes zoster (shingles), genital herpes in immunocompetent individuals, and recurrent genital herpes in HIV-infected individuals.
DB00563MethotrexateMethotrexate is indicated in the treatment of gestational choriocarcinoma, chorioadenoma destruens and hydatidiform mole. In acute lymphocytic leukemia, methotrexate is indicated in the prophylaxis of meningeal leukemia and is used in maintenance therapy in combination with other chemotherapeutic agents. Methotrexate is also indicated in the treatment of meningeal leukemia. Methotrexate is used alone or in combination with other anticancer agents in the treatment of breast cancer, epidermoid cancers of the head and neck, advanced mycosis fungoides (cutaneous T cell lymphoma), and lung cancer, particularly squamous cell and small cell types. Methotrexate is also used in combination with other chemotherapeutic agents in the treatment of advanced stage non-Hodgkin’s lymphomas. Methotrexate is indicated in the symptomatic control of severe, recalcitrant, disabling psoriasis. Methotrexate is indicated in the management of selected adults with severe, active rheumatoid arthritis (ACR criteria), or children with active polyarticular-course juvenile rheumatoid arthritis.
DB00864TacrolimusFor use after allogenic organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It was first approved by the FDA in 1994 for use in liver transplantation, this has been extended to include kidney, heart, small bowel, pancreas, lung, trachea, skin, cornea, and limb transplants. It has also been used in a topical preparation in the treatment of severe atopic dermatitis.
DB13868AdefovirNot Available
DB00718Adefovir DipivoxilFor the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease.
DB00369CidofovirFor the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS)
DB12151BrincidofovirNot Available
DB00282PamidronateFor the treatment of moderate or severe hypercalcemia associated with malignancy
DB01601LopinavirIndicated in combination with other antiretroviral agents for the treatment of HIV-infection.
DB14713InotersenInotersen is a transthyretin-directed antisense oligonucleotide indicated for treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults [FDA label], [F1938].
DB00803ColistinFor the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly Pseudomonas aeruginosa.
DrugDrug NameTargetType
DB00681Amphotericin BCytochrome P450 3A4enzyme
DB00681Amphotericin BErgosteroltarget
DB00515CisplatinSerum albumincarrier
DB00515CisplatinProstaglandin G/H synthase 2enzyme
DB00515CisplatinMyeloperoxidaseenzyme
DB00515CisplatinXanthine dehydrogenase/oxidaseenzyme
DB00515CisplatinArylamine N-acetyltransferaseenzyme
DB00515CisplatinCytochrome P450 2C9enzyme
DB00515CisplatinCytochrome P450 2B6enzyme
DB00515CisplatinCholinesteraseenzyme
DB00515CisplatinCytochrome P450 4A11enzyme
DB00515CisplatinGlutathione S-transferase theta-1enzyme
DB00515CisplatinMetallothionein-1Aenzyme
DB00515CisplatinMetallothionein-2enzyme
DB00515CisplatinSuperoxide dismutase [Cu-Zn]enzyme
DB00515CisplatinGlutathione S-transferase Penzyme
DB00515CisplatinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00515CisplatinGlutathione S-transferase Mu 1enzyme
DB00515CisplatinDNAtarget
DB00515CisplatinDNA-3-methyladenine glycosylasetarget
DB00515CisplatinAlpha-2-macroglobulintarget
DB00515CisplatinSerotransferrintarget
DB00515CisplatinCopper transport protein ATOX1target
DB00515CisplatinCanalicular multispecific organic anion transporter 2transporter
DB00515CisplatinMultidrug resistance-associated protein 5transporter
DB00515CisplatinCanalicular multispecific organic anion transporter 1transporter
DB00515CisplatinSolute carrier family 22 member 2transporter
DB00515CisplatinHigh affinity copper uptake protein 1transporter
DB00515CisplatinProbable low affinity copper uptake protein 2transporter
DB00515CisplatinMultidrug resistance-associated protein 6transporter
DB00515CisplatinMultidrug resistance protein 1transporter
DB00515CisplatinCopper-transporting ATPase 2transporter
DB00515CisplatinCopper-transporting ATPase 1transporter
DB00515CisplatinATP-binding cassette sub-family G member 2transporter
DB01111ColistimethateBacterial outer membranetarget
DB00529FoscarnetDNA polymerase catalytic subunittarget
DB00529FoscarnetDNA polymerase catalytic subunittarget
DB00529FoscarnetSolute carrier family 22 member 6transporter
DB00529FoscarnetMonocarboxylate transporter 1transporter
DB00742MannitolMannitol dehydrogenaseenzyme
DB00742MannitolMultidrug resistance protein 1transporter
DB00512VancomycinSerum albumincarrier
DB00512Vancomycinalpha1-acid glycoproteincarrier
DB00512VancomycinGamma Globulincarrier
DB00512VancomycinD-Ala-D-Ala moiety of NAM/NAG peptide subunits of peptidoglycantarget
DB00091CyclosporineCytochrome P450 3A5enzyme
DB00091CyclosporineCytochrome P450 3A4enzyme
DB00091CyclosporineCytochrome P450 3A7enzyme
DB00091CyclosporineCytochrome P450 2C19enzyme
DB00091CyclosporineCytochrome P450 2C8enzyme
DB00091CyclosporineCytochrome P450 2C9enzyme
DB00091CyclosporineCytochrome P450 2D6enzyme
DB00091CyclosporineCalcium signal-modulating cyclophilin ligandtarget
DB00091CyclosporinePeptidyl-prolyl cis-trans isomerase Atarget
DB00091CyclosporineCalcineurin subunit B type 2target
DB00091CyclosporinePeptidyl-prolyl cis-trans isomerase F, mitochondrialtarget
DB00091CyclosporineMultidrug resistance protein 1transporter
DB00091CyclosporineCanalicular multispecific organic anion transporter 2transporter
DB00091CyclosporineBile salt export pumptransporter
DB00091CyclosporineMultidrug resistance-associated protein 1transporter
DB00091CyclosporineSolute carrier organic anion transporter family member 1A2transporter
DB00091CyclosporineIleal sodium/bile acid cotransportertransporter
DB00091CyclosporineSodium/bile acid cotransportertransporter
DB00091CyclosporineSolute carrier family 22 member 6transporter
DB00091CyclosporineMultidrug resistance-associated protein 7transporter
DB00091CyclosporineCanalicular multispecific organic anion transporter 1transporter
DB00091CyclosporineATP-binding cassette sub-family G member 2transporter
DB00091CyclosporineSolute carrier organic anion transporter family member 1B1transporter
DB00229CefotiamPenicillin-binding protein 1Atarget
DB00229CefotiamSolute carrier family 22 member 6transporter
DB00229CefotiamSolute carrier family 22 member 8transporter
DB00274CefmetazoleSerum albumincarrier
DB00274CefmetazolePenicillin binding protein 2atarget
DB00274CefmetazolePenicillin-binding protein 1Atarget
DB00274CefmetazolePenicillin-binding protein 1Btarget
DB00274CefmetazolePeptidoglycan synthase FtsItarget
DB00274CefmetazoleD-alanyl-D-alanine carboxypeptidase DacAtarget
DB00274CefmetazoleD-alanyl-D-alanine carboxypeptidase DacCtarget
DB00274CefmetazoleSolute carrier family 15 member 1transporter
DB00274CefmetazoleSolute carrier family 15 member 2transporter
DB00447LoracarbefPenicillin-binding protein 1Atarget
DB00447LoracarbefPenicillin-binding protein 3target
DB00447LoracarbefSolute carrier family 15 member 1transporter
DB00447LoracarbefSolute carrier family 15 member 2transporter
DB00833CefaclorMyeloperoxidaseenzyme
DB00833CefaclorPenicillin-binding protein 1Atarget
DB00833CefaclorPenicillin-binding protein 3target
DB00833CefaclorSolute carrier family 15 member 1transporter
DB00833CefaclorSolute carrier family 15 member 2transporter
DB00833CefaclorSolute carrier family 22 member 8transporter
DB00833CefaclorBile salt export pumptransporter
DB00923CeforanidePenicillin-binding protein 2target
DB01150CefprozilPenicillin-binding protein 1Atarget
DB01150CefprozilPenicillin-binding protein 2xtarget
DB01150CefprozilPenicillin-binding protein 2Btarget
DB01326CefamandolePenicillin-binding protein 2target
DB01326CefamandoleSolute carrier family 22 member 6transporter
DB01326CefamandoleSolute carrier family 22 member 8transporter
DB01326CefamandoleSolute carrier family 22 member 11transporter
DB01326CefamandoleSolute carrier family 22 member 7transporter
DB01328CefonicidSerum albumincarrier
DB01328CefonicidPenicillin-binding protein 1Atarget
DB01328CefonicidPeptidoglycan synthase FtsItarget
DB01328CefonicidPenicillin-binding protein 1Btarget
DB01328CefonicidD-alanyl-D-alanine carboxypeptidase DacBtarget
DB01328CefonicidPenicillin-binding protein 2target
DB01330CefotetanSerum albumincarrier
DB01330CefotetanPenicillin-binding protein 3target
DB01331CefoxitinBeta-lactamaseenzyme
DB01331CefoxitinPenicillin-binding protein 1Atarget
DB01331CefoxitinPenicillin-binding protein 1Btarget
DB01331CefoxitinPeptidoglycan synthase FtsItarget
DB01331CefoxitinD-alanyl-D-alanine carboxypeptidase DacAtarget
DB01331CefoxitinD-alanyl-D-alanine carboxypeptidase DacBtarget
DB01331CefoxitinD-alanyl-D-alanine carboxypeptidase DacCtarget
DB01331CefoxitinD-alanyl-D-alanine endopeptidasetarget
DB01331CefoxitinPenicillin-binding protein 3target
DB01331CefoxitinPenicillin-binding protein 1btarget
DB01331CefoxitinPenicillin-binding protein 2atarget
DB01331CefoxitinPenicillin-binding protein 1Atarget
DB01331CefoxitinPenicillin-binding protein 2Btarget
DB01112CefuroximePenicillin-binding protein 1Atarget
DB01112CefuroximeSolute carrier family 15 member 1transporter
DB01112CefuroximeSolute carrier family 15 member 2transporter
DB00267CefmenoximePenicillin-binding protein 1Atarget
DB00267CefmenoximePeptidoglycan synthase FtsItarget
DB00430CefpiramideSerum albumincarrier
DB00430CefpiramidePenicillin binding protein 2atarget
DB00430CefpiramidePeptidoglycan synthase FtsItarget
DB00430CefpiramidePenicillin-binding protein 1Btarget
DB00430CefpiramidePenicillin-binding protein 1Atarget
DB00430CefpiramidePenicillin-binding protein 1Btarget
DB00430CefpiramideD-alanyl-D-alanine carboxypeptidase DacCtarget
DB00430CefpiramidePenicillin-binding protein 1Atarget
DB00438CeftazidimePeptidoglycan synthase FtsItarget
DB00438CeftazidimePenicillin-binding protein 3target
DB00438CeftazidimePenicillin-binding protein 1Atarget
DB00438CeftazidimePenicillin-binding protein 1Atarget
DB00438CeftazidimePenicillin-binding protein 1Btarget
DB00438CeftazidimePenicillin-binding protein 1Btarget
DB00438CeftazidimePenicillin-binding protein 2target
DB00438CeftazidimePenicillin-binding protein 2target
DB00438CeftazidimeD-alanyl-D-alanine endopeptidasetarget
DB00438CeftazidimeSolute carrier family 22 member 5transporter
DB00438CeftazidimeSolute carrier family 15 member 1transporter
DB00438CeftazidimeSolute carrier family 15 member 2transporter
DB00438CeftazidimeSolute carrier family 22 member 6transporter
DB00493CefotaximePenicillin-binding protein 3target
DB00493CefotaximePenicillin-binding protein 1btarget
DB00493CefotaximePenicillin-binding protein 2atarget
DB00493CefotaximePenicillin-binding protein 1Atarget
DB00493CefotaximePenicillin-binding protein 2Btarget
DB00493CefotaximeSolute carrier family 22 member 6target
DB00493CefotaximeSolute carrier family 22 member 8target
DB00493CefotaximeSolute carrier family 22 member 11target
DB00493CefotaximeSolute carrier family 22 member 7target
DB00493CefotaximeSolute carrier family 15 member 1target
DB00493CefotaximeSerum albumintarget
DB00493CefotaximeBeta-lactamasetarget
DB00493CefotaximeSolute carrier family 15 member 2target
DB00493CefotaximeSolute carrier family 15 member 1transporter
DB00493CefotaximeSolute carrier family 15 member 2transporter
DB00493CefotaximeSolute carrier family 22 member 6transporter
DB00493CefotaximeSolute carrier family 22 member 8transporter
DB00493CefotaximeSolute carrier family 22 member 11transporter
DB00493CefotaximeSolute carrier family 22 member 7transporter
DB01066CefditorenPenicillin-binding protein 1Atarget
DB01066CefditorenPenicillin-binding protein 2Btarget
DB01212CeftriaxoneSerum albumincarrier
DB01212CeftriaxoneGlutamine synthetaseenzyme
DB01212CeftriaxonePenicillin-binding protein 2Btarget
DB01212CeftriaxoneSolute carrier family 22 member 11target
DB01212CeftriaxoneSolute carrier family 22 member 6target
DB01212CeftriaxoneSolute carrier family 22 member 8target
DB01212CeftriaxoneSolute carrier family 15 member 1target
DB01212CeftriaxoneSolute carrier family 15 member 1transporter
DB01212CeftriaxoneSolute carrier family 15 member 2transporter
DB01212CeftriaxoneSolute carrier family 22 member 6transporter
DB01212CeftriaxoneSolute carrier family 22 member 8transporter
DB01212CeftriaxoneSolute carrier family 22 member 11transporter
DB01329CefoperazoneSerum albumincarrier
DB01329CefoperazonePeptidoglycan synthase FtsItarget
DB01329CefoperazonePenicillin-binding protein 1Btarget
DB01329CefoperazonePenicillin-binding protein 2target
DB01329CefoperazonePenicillin-binding protein 1Atarget
DB01329CefoperazoneD-alanyl-D-alanine carboxypeptidase DacCtarget
DB01329CefoperazoneD-alanyl-D-alanine carboxypeptidase DacAtarget
DB01329CefoperazoneD-alanyl-D-alanine carboxypeptidase DacBtarget
DB01329CefoperazonePenicillin-binding protein 1Atarget
DB01329CefoperazonePenicillin-binding protein 1Btarget
DB01329CefoperazoneSolute carrier family 22 member 6transporter
DB01329CefoperazoneSolute carrier family 22 member 8transporter
DB01329CefoperazoneSolute carrier family 22 member 11transporter
DB01329CefoperazoneSolute carrier family 22 member 7transporter
DB01332CeftizoximePeptidoglycan synthase FtsItarget
DB01332CeftizoximePenicillin-binding protein 1Atarget
DB01332CeftizoximePenicillin-binding protein 1Btarget
DB01332CeftizoximeMecA PBP2' (penicillin binding protein 2')target
DB01332CeftizoximeSolute carrier family 15 member 1transporter
DB01332CeftizoximeSolute carrier family 22 member 6transporter
DB01332CeftizoximeSolute carrier family 22 member 8transporter
DB01415CeftibutenPeptidoglycan synthase FtsItarget
DB01415CeftibutenPenicillin-binding protein 1Atarget
DB01415CeftibutenPenicillin-binding protein 1Btarget
DB01415CeftibutenPenicillin-binding protein 2target
DB01415CeftibutenSolute carrier family 15 member 1transporter
DB01415CeftibutenSolute carrier family 15 member 2transporter
DB01415CeftibutenSolute carrier family 22 member 6transporter
DB01415CeftibutenSolute carrier family 22 member 8transporter
DB01416CefpodoximePeptidoglycan synthase FtsItarget
DB04570LatamoxefPenicillin-binding protein 3target
DB04570LatamoxefPenicillin-binding protein 1Atarget
DB04570LatamoxefPenicillin-binding protein 1Btarget
DB04570LatamoxefD-alanyl-D-alanine carboxypeptidase DacBtarget
DB01413CefepimePenicillin-binding protein 2target
DB01413CefepimePeptidoglycan synthase FtsItarget
DB01413CefepimePenicillin-binding protein 3target
DB01413CefepimePenicillin-binding protein 2target
DB01413CefepimeSolute carrier family 22 member 5transporter
DB01413CefepimeSolute carrier family 15 member 1transporter
DB01413CefepimeSolute carrier family 15 member 2transporter
DB00479Amikacin30S ribosomal protein S12target
DB00684TobramycinAminoglycoside 2'-N-acetyltransferaseenzyme
DB00684Tobramycin30S ribosomal protein S12target
DB00684Tobramycin16S rRNAtarget
DB00798Gentamicin30S ribosomal protein S12target
DB00798Gentamicin16S rRNAtarget
DB00798GentamicinLow-density lipoprotein receptor-related protein 2target
DB00798GentamicinNH(3)-dependent NAD(+) synthetasetarget
DB00798GentamicinDihydrofolate reductasetarget
DB00798GentamicinSolute carrier family 22 member 6transporter
DB00994Neomycin30S ribosomal protein S12target
DB00994Neomycin16S rRNAtarget
DB00994NeomycinExtracellular calcium-sensing receptortarget
DB01082Streptomycin30S ribosomal protein S12target
DB01082Streptomycin16S rRNAtarget
DB01082StreptomycinProtein-arginine deiminase type-4target
DB01082StreptomycinSolute carrier family 22 member 6transporter
DB00452Framycetin30S ribosomal protein S12target
DB00452Framycetin16S rRNAtarget
DB00452FramycetinC-X-C chemokine receptor type 4target
DB00955Netilmicin30S ribosomal protein S12target
DB00955Netilmicin16S rRNAtarget
DB01172KanamycinAminoglycoside 2'-N-acetyltransferaseenzyme
DB01172KanamycinKanamycin nucleotidyltransferaseenzyme
DB01172KanamycinAminoglycoside 3'-phosphotransferaseenzyme
DB01172Kanamycin30S ribosomal protein S12target
DB01172Kanamycin16S rRNAtarget
DB01421Paromomycin16S rRNAtarget
DB01421Paromomycin30S ribosomal protein S10target
DB03615RibostamycinAminoglycoside 2'-N-acetyltransferaseenzyme
DB03615RibostamycinProtein disulfide-isomerasetarget
DB03615Ribostamycin30S ribosomal protein S12target
DB03615RibostamycinAminoglycoside N(6')-acetyltransferase type 1target
DB03615RibostamycinAminoglycoside 2'-N-acetyltransferasetarget
DB04263GeneticinOrnithine decarboxylasetarget
DB04626Apramycin16S rRNAtarget
DB04729Gentamicin C1a30S ribosomal protein S12target
DB04729Gentamicin C1a16S rRNAtarget
DB06696Arbekacin30S ribosomal protein S12target
DB08437Puromycin60S ribosomal protein L10-liketarget
DB08437Puromycin60S ribosomal protein L13atarget
DB08437Puromycin60S ribosomal protein L23target
DB08437Puromycin60S ribosomal protein L15target
DB08437Puromycin60S ribosomal protein L19target
DB08437Puromycin60S ribosomal protein L23atarget
DB08437PuromycinProbable ribosome biogenesis protein RLP24target
DB08437Puromycin60S ribosomal protein L26-like 1target
DB08437Puromycin60S ribosomal protein L8target
DB08437Puromycin60S ribosomal protein L37target
DB08437Puromycin60S ribosomal protein L3target
DB08437Puromycin60S ribosomal protein L11target
DB08437PuromycinLeucyl/phenylalanyl-tRNA--protein transferasetarget
DB12615Plazomicin30S ribosomal protein S14target
DB12615Plazomicin30S ribosomal protein S11target
DB12615PlazomicinMultidrug and toxin extrusion protein 1transporter
DB12615PlazomicinMultidrug and toxin extrusion protein 2transporter
DB00314Capreomycin70S ribosometarget
DB01050IbuprofenSerum albumincarrier
DB01050IbuprofenCytochrome P450 2C9enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 1-3enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 1-9enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 2B4enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 2B7enzyme
DB01050IbuprofenCytochrome P450 2C8enzyme
DB01050IbuprofenCytochrome P450 2C19enzyme
DB01050IbuprofenAlpha-methylacyl-CoA racemaseenzyme
DB01050IbuprofenProstaglandin G/H synthase 1target
DB01050IbuprofenProstaglandin G/H synthase 2target
DB01050IbuprofenApoptosis regulator Bcl-2target
DB01050IbuprofenThrombomodulintarget
DB01050IbuprofenFatty acid-binding protein, intestinaltarget
DB01050IbuprofenPeroxisome proliferator-activated receptor gammatarget
DB01050IbuprofenCystic fibrosis transmembrane conductance regulatortarget
DB01050IbuprofenPeroxisome proliferator-activated receptor alphatarget
DB01050IbuprofenPlatelet glycoprotein Ib alpha chaintarget
DB01050IbuprofenProtein S100-A7target
DB01050IbuprofenMultidrug resistance-associated protein 4transporter
DB01050IbuprofenMultidrug resistance-associated protein 1transporter
DB01050IbuprofenSolute carrier organic anion transporter family member 1A2transporter
DB01050IbuprofenSolute carrier family 22 member 6transporter
DB01050IbuprofenSolute carrier family 22 member 8transporter
DB01050IbuprofenSolute carrier family 22 member 11transporter
DB01050IbuprofenSolute carrier organic anion transporter family member 2B1transporter
DB01050IbuprofenMultidrug resistance protein 1transporter
DB01250OlsalazineInterferon gammatarget
DB01250OlsalazineThiopurine S-methyltransferasetarget
DB03585OxyphenbutazoneSerum albumincarrier
DB03585OxyphenbutazoneGroup IIE secretory phospholipase A2target
DB03585OxyphenbutazoneSolute carrier family 22 member 6transporter
DB04817MetamizoleCytochrome P450 2B6enzyme
DB04817MetamizoleCytochrome P450 3A4enzyme
DB04817MetamizoleProstaglandin G/H synthase 1target
DB04828ZomepiracSerum albumincarrier
DB04828ZomepiracCytochrome P450 3A4enzyme
DB04828ZomepiracProstaglandin D2 receptor 2target
DB06737ZaltoprofenUDP-glucuronosyltransferase 2B7enzyme
DB06737ZaltoprofenCytochrome P450 2C9enzyme
DB06737ZaltoprofenProstaglandin G/H synthase 1enzyme
DB07402AzapropazoneSerum albumincarrier
DB07477FelbinacCathepsin L1target
DB09212LoxoprofenProstaglandin G/H synthase 1enzyme
DB09212LoxoprofenProstaglandin G/H synthase 2enzyme
DB09212LoxoprofenProstaglandin G/H synthase 2target
DB09212LoxoprofenProstaglandin G/H synthase 1target
DB09216Tolfenamic AcidCytochrome P450 3A4enzyme
DB09216Tolfenamic AcidProstaglandin G/H synthase 1target
DB09216Tolfenamic AcidProstaglandin G/H synthase 2target
DB09288PropacetamolCholinesteraseenzyme
DB09288PropacetamolCytochrome P450 3A4enzyme
DB09288PropacetamolCytochrome P450 2E1enzyme
DB09288PropacetamolCytochrome P450 1A2enzyme
DB09288PropacetamolCytochrome P450 2D6enzyme
DB09288PropacetamolUDP-glucuronosyltransferase 1-1enzyme
DB09288PropacetamolUDP-glucuronosyltransferase 1-6enzyme
DB09288PropacetamolUDP-glucuronosyltransferase 1-9enzyme
DB09288PropacetamolUDP-glucuronosyltransferase 2B15enzyme
DB09288PropacetamolUDP-glucuronosyltransferase 1-10enzyme
DB09288PropacetamolSulfotransferase 1A1enzyme
DB09288PropacetamolSulfotransferase 1A3/1A4enzyme
DB09288PropacetamolEstrogen sulfotransferaseenzyme
DB09288PropacetamolBile salt sulfotransferaseenzyme
DB09288PropacetamolArylamine N-acetyltransferase 2enzyme
DB09288PropacetamolCytochrome P450 2C9enzyme
DB09288PropacetamolProstaglandin G/H synthase 1target
DB09288PropacetamolProstaglandin G/H synthase 2target
DB09288PropacetamolTransient receptor potential cation channel subfamily V member 1target
DB09288PropacetamolCannabinoid receptor 1target
DB13167AlclofenacProstaglandin G/H synthase 2target
DB13783AcemetacinUDP-glucuronosyltransferase 2B7enzyme
DB13783AcemetacinProstaglandin G/H synthase 1target
DB13783AcemetacinProstaglandin G/H synthase 2target
DB13783AcemetacinMultidrug resistance-associated protein 1transporter
DB01424AminophenazoneCytochrome P450 2C19enzyme
DB01424AminophenazoneCytochrome P450 1A2enzyme
DB01424AminophenazoneCytochrome P450 2C8enzyme
DB01424AminophenazoneCytochrome P450 2C9enzyme
DB01424AminophenazoneCytochrome P450 2D6enzyme
DB01424AminophenazoneCytochrome P450 3A4enzyme
DB01424AminophenazoneCytochrome P450 2C18enzyme
DB01424AminophenazoneSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
DB01424AminophenazoneSolute carrier family 22 member 6transporter
DB14059SC-236Cyclooxygenase 2target
DB14059SC-236Nuclear factor NF-kappa-B complextarget
DB14060NS-398Cyclooxygenase 2target
DB12445NitroaspirinProstaglandin G/H synthase 1target
DB09285MorniflumateArachidonate 5-lipoxygenaseenzyme
DB09285MorniflumateProstaglandin G/H synthase 2enzyme
DB09285MorniflumateUDP-glucuronosyltransferase 1A9enzyme
DB09285MorniflumateArachidonate 5-lipoxygenasetarget
DB09285MorniflumateProstaglandin G/H synthase 2target
DB09285MorniflumateLeukotriene B4 receptor 1target
DB09285MorniflumateThromboxane A2 receptortarget
DB00533RofecoxibCytochrome P450 3A4enzyme
DB00533RofecoxibCytochrome P450 1A2enzyme
DB00533RofecoxibProstaglandin G/H synthase 1enzyme
DB00533RofecoxibCytochrome P450 2C8enzyme
DB00533RofecoxibCytochrome P450 2C9enzyme
DB00533RofecoxibProstaglandin G/H synthase 2target
DB00533RofecoxibElastintarget
DB00533RofecoxibMultidrug resistance-associated protein 4transporter
DB00580ValdecoxibCytochrome P450 2C9enzyme
DB00580ValdecoxibCytochrome P450 3A4enzyme
DB00580ValdecoxibUDP-glucuronosyltransferase 1-9enzyme
DB00580ValdecoxibProstaglandin G/H synthase 2target
DB00580ValdecoxibCarbonic anhydrase 2target
DB00580ValdecoxibCarbonic anhydrase 3target
DB01283LumiracoxibCytochrome P450 2C9enzyme
DB01283LumiracoxibCytochrome P450 2C19enzyme
DB01283LumiracoxibUDP-glucuronosyltransferase 1-9enzyme
DB01283LumiracoxibCytochrome P450 1A2enzyme
DB01283LumiracoxibProstaglandin G/H synthase 2target
DB01283LumiracoxibProstaglandin G/H synthase 1target
DB01628EtoricoxibCytochrome P450 3A4enzyme
DB01628EtoricoxibCytochrome P450 2C9enzyme
DB01628EtoricoxibCytochrome P450 2D6enzyme
DB01628EtoricoxibCytochrome P450 1A2enzyme
DB01628EtoricoxibCytochrome P450 2C19enzyme
DB01628EtoricoxibCytochrome P450 2E1enzyme
DB01628EtoricoxibProstaglandin G/H synthase 2target
DB08439ParecoxibCytochrome P450 3A4enzyme
DB08439ParecoxibCytochrome P450 2C9enzyme
DB08439ParecoxibLactotransferrintarget
DB08439ParecoxibProstaglandin G/H synthase 2target
DB00461NabumetoneMyeloperoxidaseenzyme
DB00461NabumetoneCytochrome P450 1A2enzyme
DB00461NabumetoneProstaglandin G/H synthase 1target
DB00461NabumetoneProstaglandin G/H synthase 2target
DB00482CelecoxibCytochrome P450 2C9enzyme
DB00482CelecoxibCytochrome P450 2D6enzyme
DB00482CelecoxibCytochrome P450 3A4enzyme
DB00482CelecoxibCytochrome P450 2C8enzyme
DB00482CelecoxibProstaglandin G/H synthase 2target
DB00482Celecoxib3-phosphoinositide-dependent protein kinase 1target
DB00482CelecoxibCarbonic anhydrase 2target
DB00482CelecoxibCarbonic anhydrase 3target
DB00482CelecoxibATP-binding cassette sub-family B member 5target
DB00482CelecoxibATP-binding cassette sub-family G member 2target
DB00482CelecoxibMultidrug resistance protein 1target
DB00482CelecoxibMultidrug resistance-associated protein 4transporter
DB00482CelecoxibBile salt export pumptransporter
DB00749EtodolacSerum albumincarrier
DB00749EtodolacCytochrome P450 2C9enzyme
DB00749EtodolacUDP-glucuronosyltransferase 1-9enzyme
DB00749EtodolacUDP-glucuronosyltransferase 1-3enzyme
DB00749EtodolacUDP-glucuronosyltransferase 1-10enzyme
DB00749EtodolacUDP-glucuronosyltransferase 2B7enzyme
DB00749EtodolacProstaglandin G/H synthase 1target
DB00749EtodolacProstaglandin G/H synthase 2target
DB00749EtodolacRetinoic acid receptor RXR-alphatarget
DB00749EtodolacSolute carrier family 22 member 6transporter
DB11455RobenacoxibCyclooxygenase 2target
DB00821CarprofenProstaglandin G/H synthase 2target
DB00821CarprofenProstaglandin G/H synthase 1target
DB00821CarprofenSolute carrier family 22 member 6transporter
DB00814MeloxicamCytochrome P450 2C9enzyme
DB00814MeloxicamCytochrome P450 3A4enzyme
DB00814Meloxicam6-phosphogluconate dehydrogenase, decarboxylatingenzyme
DB00814MeloxicamCytochrome P450 2C8enzyme
DB00814MeloxicamProstaglandin G/H synthase 2target
DB00814MeloxicamProstaglandin G/H synthase 1target
DB00814MeloxicamMultidrug resistance-associated protein 4transporter
DB00963BromfenacProstaglandin G/H synthase 2enzyme
DB00963BromfenacProstaglandin G/H synthase 1target
DB00963BromfenacProstaglandin G/H synthase 2target
DB04743NimesulideCytochrome P450 3A4enzyme
DB04743NimesulideProstaglandin G/H synthase 2target
DB04743NimesulideGroup IIE secretory phospholipase A2target
DB04743NimesulideLactotransferrintarget
DB06802NepafenacProstaglandin G/H synthase 1target
DB06802NepafenacProstaglandin G/H synthase 2target
DB04552Niflumic AcidUDP-glucuronosyltransferase 1-9enzyme
DB04552Niflumic AcidPhospholipase A2target
DB04552Niflumic AcidChloride channel protein ClC-Katarget
DB04552Niflumic AcidProstaglandin G/H synthase 2target
DB04552Niflumic AcidProstaglandin G/H synthase 1target
DB04552Niflumic AcidCytosolic phospholipase A2target
DB04552Niflumic AcidUDP-glucuronosyltransferase 1-9target
DB04552Niflumic AcidMonocarboxylate transporter 2transporter
DB04552Niflumic AcidMonocarboxylate transporter 1transporter
DB05095CimicoxibProstaglandin G/H synthase 2enzyme
DB05095CimicoxibProstaglandin G/H synthase 2target
DB06736AceclofenacCytochrome P450 2C9enzyme
DB06736AceclofenacProstaglandin G/H synthase 2target
DB06736AceclofenacProstaglandin G/H synthase 1target
DB09217FirocoxibProstaglandin G/H synthase 2target
DB09295TalniflumateProstaglandin G/H synthase 1enzyme
DB09295TalniflumateProstaglandin G/H synthase 2enzyme
DB09295TalniflumateProstaglandin G/H synthase 1target
DB09295TalniflumateProstaglandin G/H synthase 2target
DB09295TalniflumateChloride channel protein ClC-Katarget
DB00244MesalazineProstaglandin G/H synthase 1target
DB00244MesalazineProstaglandin G/H synthase 2target
DB00244MesalazinePeroxisome proliferator-activated receptor gammatarget
DB00244MesalazineInhibitor of nuclear factor kappa-B kinase subunit alphatarget
DB00244MesalazineInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB00244MesalazineArachidonate 5-lipoxygenasetarget
DB00244MesalazineMyeloperoxidasetarget
DB00244MesalazineArylamine N-acetyltransferasetarget
DB00328IndomethacinSerum albumincarrier
DB00328IndomethacinCytochrome P450 2C19enzyme
DB00328IndomethacinUDP-glucuronosyltransferase 1-9enzyme
DB00328IndomethacinCytochrome P450 2C9enzyme
DB00328IndomethacinUDP-glucuronosyltransferase 1-1enzyme
DB00328IndomethacinLiver carboxylesterase 1enzyme
DB00328IndomethacinUDP-glucuronosyltransferase 2B7enzyme
DB00328IndomethacinProstaglandin G/H synthase 1target
DB00328IndomethacinProstaglandin G/H synthase 2target
DB00328IndomethacinPhospholipase A2, membrane associatedtarget
DB00328IndomethacinProstaglandin reductase 2target
DB00328IndomethacinLactoylglutathione lyasetarget
DB00328IndomethacinProstaglandin D2 receptor 2target
DB00328IndomethacinPeroxisome proliferator-activated receptor gammatarget
DB00328IndomethacinPeroxisome proliferator-activated receptor alphatarget
DB00328IndomethacinAldo-keto reductase family 1 member C3target
DB00328IndomethacinCanalicular multispecific organic anion transporter 2transporter
DB00328IndomethacinMultidrug resistance-associated protein 4transporter
DB00328IndomethacinMultidrug resistance-associated protein 6transporter
DB00328IndomethacinMultidrug resistance protein 1transporter
DB00328IndomethacinMultidrug resistance-associated protein 1transporter
DB00328IndomethacinSolute carrier organic anion transporter family member 1A2transporter
DB00328IndomethacinSolute carrier family 22 member 6transporter
DB00328IndomethacinSolute carrier family 22 member 8transporter
DB00328IndomethacinCanalicular multispecific organic anion transporter 1transporter
DB00328IndomethacinATP-binding cassette sub-family C member 11transporter
DB00328IndomethacinSolute carrier family 22 member 11transporter
DB00328IndomethacinSodium/bile acid cotransportertransporter
DB00328IndomethacinSolute carrier family 22 member 7transporter
DB00328IndomethacinSolute carrier organic anion transporter family member 1B1transporter
DB00328IndomethacinBile salt export pumptransporter
DB00465KetorolacProstaglandin G/H synthase 1target
DB00465KetorolacProstaglandin G/H synthase 2target
DB00469TenoxicamCytochrome P450 2C9enzyme
DB00469TenoxicamProstaglandin G/H synthase 1target
DB00469TenoxicamProstaglandin G/H synthase 2target
DB00469TenoxicamSolute carrier family 22 member 8transporter
DB00500TolmetinSerum albumincarrier
DB00500TolmetinTryptophan 2,3-dioxygenaseenzyme
DB00500TolmetinMyeloperoxidaseenzyme
DB00500TolmetinProstaglandin G/H synthase 1target
DB00500TolmetinProstaglandin G/H synthase 2target
DB00500TolmetinSolute carrier family 22 member 6transporter
DB00554PiroxicamSerum albumincarrier
DB00554PiroxicamCytochrome P450 2C9enzyme
DB00554PiroxicamCytochrome P450 2C8enzyme
DB00554PiroxicamProstaglandin G/H synthase 1target
DB00554PiroxicamProstaglandin G/H synthase 2target
DB00554PiroxicamSolute carrier family 22 member 6transporter
DB00554PiroxicamSolute carrier family 22 member 8transporter
DB00554PiroxicamSolute carrier family 22 member 11transporter
DB00554PiroxicamSolute carrier organic anion transporter family member 2B1transporter
DB00573FenoprofenSerum albumincarrier
DB00573FenoprofenProstaglandin G/H synthase 1target
DB00573FenoprofenProstaglandin G/H synthase 2target
DB00573FenoprofenPeroxisome proliferator-activated receptor alphatarget
DB00573FenoprofenPeroxisome proliferator-activated receptor gammatarget
DB00788NaproxenSerum albumincarrier
DB00788NaproxenCytochrome P450 2C9enzyme
DB00788NaproxenCytochrome P450 1A2enzyme
DB00788NaproxenCytochrome P450 2C8enzyme
DB00788NaproxenUDP-glucuronosyltransferase 1-1enzyme
DB00788NaproxenUDP-glucuronosyltransferase 2B7enzyme
DB00788NaproxenProstaglandin G/H synthase 1target
DB00788NaproxenProstaglandin G/H synthase 2target
DB00788NaproxenPeptostreptococcal albumin-binding proteintarget
DB00788NaproxenSolute carrier organic anion transporter family member 1A2transporter
DB00788NaproxenSolute carrier family 22 member 6transporter
DB00788NaproxenBile salt export pumptransporter
DB00861DiflunisalTransthyretincarrier
DB00861DiflunisalSerum albumincarrier
DB00861DiflunisalUDP-glucuronosyltransferase 1-8enzyme
DB00861DiflunisalUDP-glucuronosyltransferase 1-9enzyme
DB00861DiflunisalProstaglandin G/H synthase 1target
DB00861DiflunisalProstaglandin G/H synthase 2target
DB00861DiflunisalSolute carrier family 22 member 6transporter
DB00870SuprofenCytochrome P450 2C9enzyme
DB00870SuprofenUDP-glucuronosyltransferase 1-1enzyme
DB00870SuprofenUDP-glucuronosyltransferase 2B7enzyme
DB00870SuprofenProstaglandin G/H synthase 1target
DB00870SuprofenProstaglandin G/H synthase 2target
DB00939Meclofenamic acidProstaglandin G/H synthase 1target
DB00939Meclofenamic acidProstaglandin G/H synthase 2target
DB00939Meclofenamic acidArachidonate 5-lipoxygenasetarget
DB00939Meclofenamic acidPotassium voltage-gated channel subfamily KQT member 2target
DB00939Meclofenamic acidPotassium voltage-gated channel subfamily KQT member 3target
DB00939Meclofenamic acidSolute carrier family 22 member 6transporter
DB00939Meclofenamic acidSolute carrier organic anion transporter family member 1C1transporter
DB00945Acetylsalicylic acidSerum albumincarrier
DB00945Acetylsalicylic acidCytochrome P450 2C19enzyme
DB00945Acetylsalicylic acidCytochrome P450 2C8enzyme
DB00945Acetylsalicylic acidCytochrome P450 2C9enzyme
DB00945Acetylsalicylic acidProstaglandin G/H synthase 1target
DB00945Acetylsalicylic acidProstaglandin G/H synthase 2target
DB00945Acetylsalicylic acidAldo-keto reductase family 1 member C1target
DB00945Acetylsalicylic acid5'-AMP-activated protein kinasetarget
DB00945Acetylsalicylic acidEndothelin-1 receptortarget
DB00945Acetylsalicylic acidInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB00945Acetylsalicylic acidCellular tumor antigen p53target
DB00945Acetylsalicylic acid78 kDa glucose-regulated proteintarget
DB00945Acetylsalicylic acidRibosomal protein S6 kinase alpha-3target
DB00945Acetylsalicylic acidNF-kappa-B inhibitor alphatarget
DB00945Acetylsalicylic acidNuclear factor NF-kappa-Btarget
DB00945Acetylsalicylic acidSolute carrier family 22 member 6transporter
DB00945Acetylsalicylic acidMultidrug resistance protein 1transporter
DB00945Acetylsalicylic acidSolute carrier family 22 member 7transporter
DB01009KetoprofenSerum albumincarrier
DB01009KetoprofenCytochrome P450 2C9enzyme
DB01009KetoprofenCytochrome P450 2C8enzyme
DB01009KetoprofenUDP-glucuronosyltransferase 1-1enzyme
DB01009KetoprofenProstaglandin G/H synthase 1target
DB01009KetoprofenProstaglandin G/H synthase 2target
DB01009KetoprofenC-X-C chemokine receptor type 1target
DB01009KetoprofenMultidrug resistance-associated protein 4transporter
DB01009KetoprofenSolute carrier organic anion transporter family member 1A2transporter
DB01009KetoprofenSolute carrier family 22 member 6transporter
DB01009KetoprofenSolute carrier family 22 member 8transporter
DB01009KetoprofenSolute carrier family 22 member 11transporter
DB01009KetoprofenSolute carrier family 22 member 7transporter
DB01014BalsalazideNADPH azoreductaseenzyme
DB01014BalsalazideProstaglandin G/H synthase 1target
DB01014BalsalazideProstaglandin G/H synthase 2target
DB01014BalsalazideArachidonate 5-lipoxygenasetarget
DB01014BalsalazidePeroxisome proliferator-activated receptor gammatarget
DB00159IcosapentFatty acid-binding protein, braincarrier
DB00159IcosapentSerum albumincarrier
DB00159IcosapentProstaglandin G/H synthase 2target
DB00159IcosapentProstaglandin G/H synthase 1target
DB00159IcosapentFree fatty acid receptor 1target
DB00159IcosapentFatty acid desaturase 1target
DB00159IcosapentLong-chain-fatty-acid--CoA ligase 4target
DB00159IcosapentLong-chain-fatty-acid--CoA ligase 3target
DB00159IcosapentSodium/calcium exchanger 1target
DB00159IcosapentPeroxisome proliferator-activated receptor gammatarget
DB00159IcosapentPeroxisome proliferator-activated receptor deltatarget
DB00159IcosapentTransient receptor potential cation channel subfamily V member 1target
DB00159IcosapentPeroxisome proliferator-activated receptor alphatarget
DB00712FlurbiprofenSerum albumincarrier
DB00712FlurbiprofenCytochrome P450 2C9enzyme
DB00712FlurbiprofenUDP-glucuronosyltransferase 2B7enzyme
DB00712FlurbiprofenUDP-glucuronosyltransferase 1-1enzyme
DB00712FlurbiprofenUDP-glucuronosyltransferase 1-3enzyme
DB00712FlurbiprofenUDP-glucuronosyltransferase 1-9enzyme
DB00712FlurbiprofenUDP-glucuronosyltransferase 2B4enzyme
DB00712FlurbiprofenProstaglandin G/H synthase 2target
DB00712FlurbiprofenProstaglandin G/H synthase 1target
DB00712FlurbiprofenMultidrug resistance-associated protein 4transporter
DB00712FlurbiprofenSolute carrier family 22 member 6transporter
DB00784Mefenamic acidSerum albumincarrier
DB00784Mefenamic acidCytochrome P450 2C9enzyme
DB00784Mefenamic acidCytochrome P450 2C8enzyme
DB00784Mefenamic acidUDP-glucuronosyltransferase 1-9enzyme
DB00784Mefenamic acidProstaglandin G/H synthase 2target
DB00784Mefenamic acidProstaglandin G/H synthase 1target
DB01399SalsalateProstaglandin G/H synthase 1target
DB01399SalsalateProstaglandin G/H synthase 2target
DB00605SulindacSerum albumincarrier
DB00605SulindacCytochrome P450 1A1enzyme
DB00605SulindacProstaglandin G/H synthase 2target
DB00605SulindacAldose reductasetarget
DB00605SulindacProstaglandin G/H synthase 1target
DB00605SulindacMitogen-activated protein kinase 3target
DB00605SulindacPeroxisome proliferator-activated receptor deltatarget
DB00605SulindacProstaglandin D2 receptor 2target
DB00605SulindacAldo-keto reductase family 1 member B10target
DB00605SulindacSolute carrier family 22 member 6transporter
DB00936Salicylic acidSerum albumincarrier
DB00936Salicylic acidCytochrome P450 2C9enzyme
DB00936Salicylic acidProstaglandin G/H synthase 1target
DB00936Salicylic acidProstaglandin G/H synthase 2target
DB00936Salicylic acidAldo-keto reductase family 1 member C1target
DB00936Salicylic acidSolute carrier family 22 member 6transporter
DB00936Salicylic acidSolute carrier family 22 member 10transporter
DB00936Salicylic acidSolute carrier family 22 member 8transporter
DB00936Salicylic acidSolute carrier family 22 member 11transporter
DB00936Salicylic acidSolute carrier organic anion transporter family member 2B1transporter
DB00936Salicylic acidMonocarboxylate transporter 1transporter
DB00936Salicylic acidSolute carrier family 22 member 7transporter
DB00991OxaprozinProstaglandin G/H synthase 2target
DB00991OxaprozinProstaglandin G/H synthase 1target
DB01600Tiaprofenic acidProstaglandin G/H synthase 2target
DB01600Tiaprofenic acidProstaglandin G/H synthase 1target
DB01397Magnesium salicylateSerum albumincarrier
DB01397Magnesium salicylateProstaglandin G/H synthase 1target
DB01397Magnesium salicylateProstaglandin G/H synthase 2target
DB06725LornoxicamCytochrome P450 2C9enzyme
DB06725LornoxicamProstaglandin G/H synthase 1target
DB06725LornoxicamProstaglandin G/H synthase 2target
DB00812PhenylbutazoneCytochrome P450 2C9enzyme
DB00812PhenylbutazoneCytochrome P450 3A4enzyme
DB00812PhenylbutazoneProstaglandin G/H synthase 2target
DB00812PhenylbutazoneProstacyclin synthasetarget
DB00812PhenylbutazoneProstaglandin G/H synthase 1target
DB00812PhenylbutazoneSolute carrier family 22 member 6transporter
DB00812PhenylbutazoneSolute carrier family 22 member 8transporter
DB00812PhenylbutazoneSolute carrier family 22 member 11transporter
DB00795SulfasalazineAcetyl-CoA acetyltransferase, mitochondrialtarget
DB00795SulfasalazineCystine/glutamate transportertarget
DB00795SulfasalazineInhibitor of nuclear factor kappa-B kinase subunit alphatarget
DB00795SulfasalazineInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB00795SulfasalazineProstaglandin G/H synthase 2target
DB00795SulfasalazinePeroxisome proliferator-activated receptor gammatarget
DB00795SulfasalazineProstaglandin G/H synthase 1target
DB00795SulfasalazineArachidonate 5-lipoxygenasetarget
DB00795SulfasalazineThromboxane-A synthasetarget
DB00795SulfasalazinePhospholipase A2target
DB00795SulfasalazineATP-binding cassette sub-family G member 2transporter
DB00795SulfasalazineCanalicular multispecific organic anion transporter 1transporter
DB00795SulfasalazineProton-coupled folate transportertransporter
DB00795SulfasalazineSolute carrier organic anion transporter family member 1B1transporter
DB00795SulfasalazineSolute carrier organic anion transporter family member 1B3transporter
DB00795SulfasalazineSolute carrier organic anion transporter family member 2B1transporter
DB01435AntipyrineCytochrome P450 2C8enzyme
DB01435AntipyrineCytochrome P450 2C9enzyme
DB01435AntipyrineCytochrome P450 1A2enzyme
DB01435AntipyrineCytochrome P450 2C19enzyme
DB01435AntipyrineCytochrome P450 3A4enzyme
DB01435AntipyrineCytochrome P450 2A6enzyme
DB01435AntipyrineCytochrome P450 2B6enzyme
DB01435AntipyrineCytochrome P450 2C18enzyme
DB01435AntipyrineCytochrome P450 2D6enzyme
DB01435AntipyrineCytochrome P450 2E1enzyme
DB01435AntipyrineProstaglandin G/H synthase 2target
DB01435AntipyrineProstaglandin G/H synthase 1target
DB01435AntipyrineSolute carrier family 22 member 6transporter
DB01419AntrafenineProstaglandin G/H synthase 1target
DB01419AntrafenineProstaglandin G/H synthase 2target
DB01401Choline magnesium trisalicylateProstaglandin G/H synthase 1target
DB01401Choline magnesium trisalicylateProstaglandin G/H synthase 2target
DB09213DexibuprofenSerum albumincarrier
DB09213DexibuprofenCytochrome P450 2C9enzyme
DB09213DexibuprofenUDP-glucuronosyltransferase 1-1enzyme
DB09213DexibuprofenUDP-glucuronosyltransferase 1-3enzyme
DB09213DexibuprofenUDP-glucuronosyltransferase 1-9enzyme
DB09213DexibuprofenUDP-glucuronosyltransferase 2B4enzyme
DB09213DexibuprofenUDP-glucuronosyltransferase 2B7enzyme
DB09213DexibuprofenCytochrome P450 2C8enzyme
DB09213DexibuprofenCytochrome P450 2C19enzyme
DB09213DexibuprofenAlpha-methylacyl-CoA racemaseenzyme
DB09213DexibuprofenProstaglandin G/H synthase 1target
DB09213DexibuprofenProstaglandin G/H synthase 2target
DB09213DexibuprofenApoptosis regulator Bcl-2target
DB09213DexibuprofenThrombomodulintarget
DB09213DexibuprofenTissue-type plasminogen activatortarget
DB09213DexibuprofenFatty acid-binding protein, intestinaltarget
DB09213DexibuprofenPeroxisome proliferator-activated receptor gammatarget
DB09213DexibuprofenCystic fibrosis transmembrane conductance regulatortarget
DB09213DexibuprofenSolute carrier family 15 member 1target
DB09213DexibuprofenPeroxisome proliferator-activated receptor alphatarget
DB09213DexibuprofenPlatelet glycoprotein Ib alpha chaintarget
DB09213DexibuprofenProtein S100-A7target
DB09213DexibuprofenMultidrug resistance-associated protein 4transporter
DB09213DexibuprofenMultidrug resistance-associated protein 1transporter
DB09213DexibuprofenSolute carrier organic anion transporter family member 1A2transporter
DB09213DexibuprofenSolute carrier family 22 member 6transporter
DB09213DexibuprofenSolute carrier family 22 member 8transporter
DB09213DexibuprofenSolute carrier family 22 member 11transporter
DB09213DexibuprofenSolute carrier organic anion transporter family member 2B1transporter
DB09213DexibuprofenMultidrug resistance protein 1transporter
DB09215DroxicamProstaglandin G/H synthase 1target
DB09215DroxicamProstaglandin G/H synthase 2target
DB11079Trolamine salicylateProstaglandin G/H synthase 1target
DB11079Trolamine salicylateProstaglandin G/H synthase 2target
DB13346BufexamacProstaglandin G/H synthase 1target
DB13346BufexamacProstaglandin G/H synthase 2target
DB13346BufexamacHistone deacetylase 6target
DB13346BufexamacHistone deacetylase 10target
DB09214DexketoprofenProstaglandin G/H synthase 1enzyme
DB09214DexketoprofenProstaglandin G/H synthase 2enzyme
DB09214DexketoprofenProstaglandin G/H synthase 1target
DB09214DexketoprofenProstaglandin G/H synthase 2target
DB00586DiclofenacTransthyretincarrier
DB00586DiclofenacSerum albumincarrier
DB00586DiclofenacCytochrome P450 2C9enzyme
DB00586DiclofenacCytochrome P450 2C19enzyme
DB00586DiclofenacCytochrome P450 1A2enzyme
DB00586DiclofenacCytochrome P450 2C8enzyme
DB00586DiclofenacUDP-glucuronosyltransferase 1-1enzyme
DB00586DiclofenacUDP-glucuronosyltransferase 2B7enzyme
DB00586DiclofenacProstaglandin G/H synthase 1enzyme
DB00586DiclofenacCytochrome P450 3A4enzyme
DB00586DiclofenacCytochrome P450 1A1enzyme
DB00586DiclofenacCytochrome P450 2B6enzyme
DB00586DiclofenacCytochrome P450 2C18enzyme
DB00586DiclofenacCytochrome P450 2E1enzyme
DB00586DiclofenacProstaglandin G/H synthase 1target
DB00586DiclofenacProstaglandin G/H synthase 2target
DB00586DiclofenacArachidonate 5-lipoxygenasetarget
DB00586DiclofenacSodium channel protein type 4 subunit alphatarget
DB00586DiclofenacAcid-sensing ion channel 1target
DB00586DiclofenacPotassium voltage-gated channel subfamily KQT member 2target
DB00586DiclofenacPotassium voltage-gated channel subfamily KQT member 3target
DB00586DiclofenacPhospholipase A2, membrane associatedtarget
DB00586DiclofenacMultidrug resistance-associated protein 4transporter
DB00586DiclofenacMultidrug resistance protein 1transporter
DB00586DiclofenacMultidrug resistance-associated protein 1transporter
DB00586DiclofenacSolute carrier family 22 member 6transporter
DB00586DiclofenacSolute carrier family 22 member 8transporter
DB00586DiclofenacSolute carrier organic anion transporter family member 1C1transporter
DB00586DiclofenacSolute carrier family 22 member 11transporter
DB00586DiclofenacSolute carrier organic anion transporter family member 1B1transporter
DB00586DiclofenacBile salt export pumptransporter
DB03450Cephalothin GroupBeta-lactamase Toho-1target
DB03450Cephalothin GroupD-alanyl-D-alanine carboxypeptidasetarget
DB02247Hydrolyzed CephalothinBeta-lactamasetarget
DB00456CefalotinSerum albumincarrier
DB00456CefalotinPenicillin-binding protein 1Atarget
DB00456CefalotinD-alanyl-D-alanine carboxypeptidasetarget
DB00456CefalotinBeta-lactamasetarget
DB00456CefalotinPenicillin-binding protein 1Atarget
DB00456CefalotinPenicillin-binding protein 1btarget
DB00456CefalotinPenicillin-binding protein 3target
DB00456CefalotinPenicillin-binding protein 2atarget
DB00456CefalotinPenicillin-binding protein 2Btarget
DB00456CefalotinSolute carrier family 22 member 5transporter
DB00456CefalotinSolute carrier family 15 member 1transporter
DB00456CefalotinSolute carrier family 15 member 2transporter
DB00456CefalotinSolute carrier family 22 member 6transporter
DB00456CefalotinSolute carrier family 22 member 8transporter
DB00456CefalotinSolute carrier family 22 member 11transporter
DB00456CefalotinSolute carrier family 22 member 7transporter
DB00738PentamidineCytochrome P450 2C19enzyme
DB00738PentamidineCytochrome P450 2C8enzyme
DB00738PentamidineCytochrome P450 2D6enzyme
DB00738PentamidineCytochrome P450 1A1enzyme
DB00738PentamidineCytochrome P450 3A5enzyme
DB00738PentamidineCytochrome P450 4A11enzyme
DB00738PentamidineDNAtarget
DB00738PentamidinetRNA (cytosine(38)-C(5))-methyltransferasetarget
DB00958CarboplatinXanthine dehydrogenase/oxidaseenzyme
DB00958CarboplatinMyeloperoxidaseenzyme
DB00958CarboplatinGlutathione S-transferase theta-1enzyme
DB00958CarboplatinMetallothionein-1Aenzyme
DB00958CarboplatinMetallothionein-2enzyme
DB00958CarboplatinSuperoxide dismutase [Cu-Zn]enzyme
DB00958CarboplatinGlutathione S-transferase Penzyme
DB00958CarboplatinGlutathione S-transferase Mu 1enzyme
DB00958CarboplatinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00958CarboplatinDNAtarget
DB00958CarboplatinHigh affinity copper uptake protein 1transporter
DB00958CarboplatinProbable low affinity copper uptake protein 2transporter
DB00958CarboplatinCopper-transporting ATPase 1transporter
DB00958CarboplatinCopper-transporting ATPase 2transporter
DB00958CarboplatinATP-binding cassette sub-family G member 2transporter
DB00958CarboplatinCanalicular multispecific organic anion transporter 1transporter
DB09299Tenofovir alafenamideReverse transcriptase/RNaseHtarget
DB00300Tenofovir disoproxilAdenylate kinase 2, mitochondrialenzyme
DB00300Tenofovir disoproxilAdenylate kinase 4, mitochondrialenzyme
DB00300Tenofovir disoproxilNucleoside diphosphate kinase Aenzyme
DB00300Tenofovir disoproxilNucleoside diphosphate kinase Benzyme
DB00300Tenofovir disoproxilReverse transcriptase/RNaseHtarget
DB00300Tenofovir disoproxilSolute carrier family 22 member 6transporter
DB00300Tenofovir disoproxilSolute carrier family 22 member 8transporter
DB00300Tenofovir disoproxilMultidrug resistance-associated protein 7transporter
DB00300Tenofovir disoproxilMultidrug resistance-associated protein 4transporter
DB00300Tenofovir disoproxilCanalicular multispecific organic anion transporter 1transporter
DB00567CephalexinSerum albumincarrier
DB00567CephalexinCytochrome P450 3A4enzyme
DB00567CephalexinPenicillin-binding protein 3target
DB00567CephalexinPenicillin-binding protein 2atarget
DB00567CephalexinPenicillin-binding protein 1btarget
DB00567CephalexinPenicillin-binding protein 1Atarget
DB00567CephalexinPenicillin-binding protein 2Btarget
DB00567CephalexinSolute carrier family 22 member 5transporter
DB00567CephalexinSolute carrier family 15 member 1transporter
DB00567CephalexinSolute carrier family 15 member 2transporter
DB00567CephalexinSolute carrier family 22 member 6transporter
DB00567CephalexinSolute carrier family 22 member 8transporter
DB00567CephalexinMultidrug and toxin extrusion protein 1transporter
DB01139CefapirinPenicillin-binding protein 1Atarget
DB01140CefadroxilPenicillin-binding protein 3target
DB01140CefadroxilPenicillin-binding protein 1Atarget
DB01140CefadroxilPenicillin-binding protein 1btarget
DB01140CefadroxilPenicillin-binding protein 2Btarget
DB01140CefadroxilSolute carrier family 22 member 5transporter
DB01140CefadroxilSolute carrier family 15 member 1transporter
DB01140CefadroxilSolute carrier family 15 member 2transporter
DB01140CefadroxilSolute carrier family 22 member 6transporter
DB01140CefadroxilSolute carrier family 22 member 8transporter
DB01327CefazolinSerum albumincarrier
DB01327CefazolinThiopurine S-methyltransferaseenzyme
DB01327CefazolinSerum paraoxonase/arylesterase 1target
DB01327CefazolinPenicillin-binding protein 1Atarget
DB01327CefazolinPenicillin-binding protein 1Btarget
DB01327CefazolinPenicillin-binding protein 2target
DB01327CefazolinPenicillin-binding protein 1Ctarget
DB01327CefazolinPeptidoglycan synthase FtsItarget
DB01327CefazolinInterleukin-15target
DB01327CefazolinInterleukin-2target
DB01327CefazolinSolute carrier family 22 member 6transporter
DB01327CefazolinSolute carrier family 22 member 8transporter
DB01327CefazolinSolute carrier family 22 member 11transporter
DB01327CefazolinMultidrug resistance-associated protein 4transporter
DB01333CefradineCytochrome P450 3A4enzyme
DB01333CefradinePenicillin-binding protein 1Atarget
DB01333CefradineSolute carrier family 22 member 5transporter
DB01333CefradineSolute carrier family 15 member 1transporter
DB01333CefradineSolute carrier family 15 member 2transporter
DB01333CefradineSolute carrier family 22 member 6transporter
DB01333CefradineMultidrug and toxin extrusion protein 1transporter
DB01414CefacetrilePenicillin-binding protein 1Atarget
DB01414CefacetrilePenicillin-binding protein 1Btarget
DB01414CefacetrileSolute carrier family 22 member 6transporter
DB01414CefacetrileSolute carrier family 22 member 8transporter
DB09008CephaloridineSolute carrier family 22 member 6transporter
DB09008CephaloridineSolute carrier family 22 member 8transporter
DB11367CefroxadineBeta-lactamaseenzyme
DB11367CefroxadinePenicillin-binding protein 1Btarget
DB00689CephaloglycinPenicillin-binding protein 1 (PBP1)target
DB00689CephaloglycinSolute carrier family 22 member 5transporter
DB04918CeftobiproleMecAtarget
DB04918CeftobiprolePenicillin-binding protein 2xtarget
DB04918CeftobiprolePeptidoglycan synthase FtsItarget
DB00626BacitracinAlpha-2-macroglobulintarget
DB00626BacitracinInsulin-degrading enzymetarget
DB00626BacitracinC55-isoprenyl pyrophosphatetarget
DB00787AcyclovirDNA polymerase catalytic subunittarget
DB00787AcyclovirDNA polymerase catalytic subunittarget
DB00787AcyclovirThymidine kinasetarget
DB00787AcyclovirSolute carrier family 22 member 1transporter
DB00787AcyclovirSolute carrier family 22 member 6transporter
DB00787AcyclovirSolute carrier family 22 member 8transporter
DB00787AcyclovirIleal sodium/bile acid cotransportertransporter
DB00787AcyclovirMultidrug and toxin extrusion protein 1transporter
DB00787AcyclovirMultidrug and toxin extrusion protein 2transporter
DB00577ValaciclovirThymidine kinasetarget
DB00577ValaciclovirDNA polymerase catalytic subunittarget
DB00577ValaciclovirSolute carrier family 15 member 1transporter
DB00577ValaciclovirSolute carrier family 15 member 2transporter
DB00577ValaciclovirSolute carrier family 22 member 8transporter
DB00577ValaciclovirSolute carrier family 22 member 6transporter
DB00577ValaciclovirSodium- and chloride-dependent neutral and basic amino acid transporter B(0+)transporter
DB00577ValaciclovirIleal sodium/bile acid cotransportertransporter
DB00563MethotrexateSerum albumincarrier
DB00563MethotrexateAldehyde oxidaseenzyme
DB00563MethotrexateMethylenetetrahydrofolate reductaseenzyme
DB00563Methotrexate6-phosphogluconate dehydrogenase, decarboxylatingenzyme
DB00563MethotrexateFolylpolyglutamate synthase, mitochondrialenzyme
DB00563MethotrexateGamma-glutamyl hydrolaseenzyme
DB00563MethotrexateDihydrofolate reductaseenzyme
DB00563MethotrexateThymidylate synthaseenzyme
DB00563MethotrexateBifunctional purine biosynthesis protein PURHenzyme
DB00563MethotrexateCytochrome P450 3A4enzyme
DB00563MethotrexateDihydrofolate reductasetarget
DB00563MethotrexateCanalicular multispecific organic anion transporter 2transporter
DB00563MethotrexateMultidrug resistance-associated protein 4transporter
DB00563MethotrexateMultidrug resistance-associated protein 1transporter
DB00563MethotrexateSolute carrier family 22 member 6transporter
DB00563MethotrexateMultidrug resistance-associated protein 7transporter
DB00563MethotrexateSolute carrier family 22 member 8transporter
DB00563MethotrexateCanalicular multispecific organic anion transporter 1transporter
DB00563MethotrexateMultidrug resistance protein 1transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1A2transporter
DB00563MethotrexateMonocarboxylate transporter 1transporter
DB00563MethotrexateATP-binding cassette sub-family C member 11transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1B3transporter
DB00563MethotrexateSolute carrier family 22 member 11transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1C1transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 3A1transporter
DB00563MethotrexateATP-binding cassette sub-family G member 2transporter
DB00563MethotrexateSolute carrier family 22 member 7transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1B1transporter
DB00563MethotrexateProton-coupled folate transportertransporter
DB00563MethotrexateSolute carrier organic anion transporter family member 4C1transporter
DB00563MethotrexateFolate transporter 1transporter
DB00563MethotrexateFolate receptor alphatransporter
DB00864TacrolimusSerum albumincarrier
DB00864TacrolimusAlpha-1-acid glycoprotein 1carrier
DB00864TacrolimusCytochrome P450 3A4enzyme
DB00864TacrolimusCytochrome P450 3A5enzyme
DB00864TacrolimusCytochrome P450 3A7enzyme
DB00864TacrolimusPeptidyl-prolyl cis-trans isomerase FKBP1Atarget
DB00864TacrolimusMultidrug resistance protein 1transporter
DB00864TacrolimusATP-binding cassette sub-family A member 5transporter
DB00864TacrolimusSolute carrier organic anion transporter family member 1B1transporter
DB13868AdefovirDNA polymerase/reverse transcriptasetarget
DB00718Adefovir DipivoxilAdenylate kinase 2, mitochondrialenzyme
DB00718Adefovir DipivoxilAdenylate kinase 4, mitochondrialenzyme
DB00718Adefovir DipivoxilNucleoside diphosphate kinase Aenzyme
DB00718Adefovir DipivoxilNucleoside diphosphate kinase Benzyme
DB00718Adefovir DipivoxilDNA polymerase/reverse transcriptasetarget
DB00718Adefovir DipivoxilSolute carrier family 22 member 6transporter
DB00718Adefovir DipivoxilMultidrug resistance-associated protein 4transporter
DB00718Adefovir DipivoxilMultidrug resistance-associated protein 5transporter
DB00718Adefovir DipivoxilSolute carrier family 22 member 3transporter
DB00369CidofovirThymidine phosphorylaseenzyme
DB00369CidofovirDNA polymerase catalytic subunittarget
DB00369CidofovirSolute carrier family 22 member 6transporter
DB00282PamidronateFarnesyl pyrophosphate synthasetarget
DB00282PamidronateHydroxylapatitetarget
DB01601LopinavirCytochrome P450 3A4enzyme
DB01601LopinavirCytochrome P450 2D6enzyme
DB01601LopinavirCytochrome P450 2C19enzyme
DB01601LopinavirCytochrome P450 2B6enzyme
DB01601LopinavirCytochrome P450 2C9enzyme
DB01601LopinavirCytochrome P450 2C8enzyme
DB01601LopinavirCYP3Aenzyme
DB01601LopinavirHuman immunodeficiency virus type 1 proteasetarget
DB01601LopinavirMultidrug resistance protein 1transporter
DB01601LopinavirSolute carrier organic anion transporter family member 1B1transporter
DB01601LopinavirSolute carrier organic anion transporter family member 1B3transporter
DB01601LopinavirBile salt export pumptransporter
DB14713InotersenTransthyretin mRNAtarget
DB00803ColistinBacterial outer membranetarget