Sinecatechins

Identification

Name
Sinecatechins
Accession Number
DB01266
Type
Small Molecule
Groups
Approved, Investigational, Nutraceutical
Description

Sinecatechins is a botanical drug product for topical use. It is a partially purified fraction of the water extract of green tea leaves from Camellia sinensis, and is a mixture of catechins and other green tea components. Catechins constitute 85 to 95% (by weight) of the total drug substance which includes more than 55% of Epigallocatechin gallate (EGCg), other catechin derivatives such as Epicatechin (EC), Epigallocatechin (EGC), Epicatechin gallate (ECg) and some additional minor catechin derivatives i.e. Gallocatechin gallate (GCg), Gallocatechin (GC), Catechin gallate (Cg), and Catechin (C). In addition to the known catechin components, it also contains gallic acid, caffeine, and theobromine which together constitute about 2.5% of the drug substance. The remaining amount of the drug substance contains undefined botanical constituents derived from green tea leaves.

Synonyms
  • Kunecatechins
  • Sinecatechins
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
VeregenOintment150 mg/1gTopicalPharmaDerm a division of Fougera Pharmaceuticals Inc.2007-12-14Not applicableUs
VeregenOintment10 %TopicalPaladin Labs Inc2014-07-04Not applicableCanada
Categories
UNII
T432289GYZ
CAS number
188265-33-0
Weight
Not Available
Chemical Formula
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication

For the topical treatment of external genital and perianal warts (Condylomata acuminata) in immunocompetent patients 18 years and older.

Associated Conditions
Pharmacodynamics

The mode of action of Sinecatechins (as ointment) involved in the clearance of genital and perianal warts is unknown. In vitro, sinecatechins had anti-oxidative activity; the clinical significance of this finding is unknown.

Mechanism of action

While the exact mechanism of action of catechins is unknown, they are powerful anti-oxidants and are linked to to evidence of fighting tumors as well as enhancing immune system function.

Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Substance
46506183
PharmGKB
PA164749508
Wikipedia
Sinecatechins
ATC Codes
D06BB12 — Sinecatechins
AHFS Codes
  • 84:04.06 — Antivirals

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedTreatmentExternal Genital Warts1
2, 3CompletedTreatmentBasal Cell Carcinoma (BCC)1
4RecruitingTreatmentArousal Disorders, Sexual / Female Sexual Dysfunction (FSD) / Painful Intercourse / Postmenopausal Syndrome / Sexual Pain Disorders / Vestibulodynia / Vulvar Vestibulitis / Vulvodynia / Vulvovaginal Atrophy1
Not AvailableCompletedTreatmentExternal Genital Warts1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
  • Doak Dermatologics
Dosage forms
FormRouteStrength
OintmentTopical10 %
OintmentTopical150 mg/1g
Prices
Unit descriptionCostUnit
Veregen 15% ointment19.86USD g
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5795911No1998-08-182020-10-31Us
US5968973No1999-10-192017-04-10Us
US7858662No2010-12-282026-10-02Us
US9770406No2017-09-262025-07-12Us

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on May 16, 2007 14:06 / Updated on February 21, 2019 09:18