Sinecatechins
Identification
- Name
- Sinecatechins
- Accession Number
- DB01266
- Type
- Small Molecule
- Groups
- Approved, Investigational, Nutraceutical
- Description
Sinecatechins is a botanical drug product for topical use. It is a partially purified fraction of the water extract of green tea leaves from Camellia sinensis, and is a mixture of catechins and other green tea components. Catechins constitute 85 to 95% (by weight) of the total drug substance which includes more than 55% of Epigallocatechin gallate (EGCg), other catechin derivatives such as Epicatechin (EC), Epigallocatechin (EGC), Epicatechin gallate (ECg) and some additional minor catechin derivatives i.e. Gallocatechin gallate (GCg), Gallocatechin (GC), Catechin gallate (Cg), and Catechin (C). In addition to the known catechin components, it also contains gallic acid, caffeine, and theobromine which together constitute about 2.5% of the drug substance. The remaining amount of the drug substance contains undefined botanical constituents derived from green tea leaves.
- Synonyms
- Kunecatechins
- Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Veregen Ointment 10 % Topical Paladin Labs Inc 2014-07-04 Not applicable Canada 
Veregen Ointment 150 mg/g Topical Pharma Derm, A Division Of Fougera Pharmaceuticals Inc. 2007-12-14 Not applicable US 
- Categories
- UNII
- T432289GYZ
- CAS number
- 188265-33-0
- Weight
- Not Available
- Chemical Formula
- Not Available
- InChI Key
- Not Available
- InChI
- Not Available
- IUPAC Name
- Not Available
- SMILES
- Not Available
Pharmacology
- Indication
For the topical treatment of external genital and perianal warts (Condylomata acuminata) in immunocompetent patients 18 years and older.
- Structured Indications
- Pharmacodynamics
The mode of action of Sinecatechins (as ointment) involved in the clearance of genital and perianal warts is unknown. In vitro, sinecatechins had anti-oxidative activity; the clinical significance of this finding is unknown.
- Mechanism of action
While the exact mechanism of action of catechins is unknown, they are powerful anti-oxidants and are linked to to evidence of fighting tumors as well as enhancing immune system function.
- Absorption
- Not Available
- Volume of distribution
- Not Available
- Protein binding
- Not Available
- Metabolism
- Not Available
- Route of elimination
- Not Available
- Half life
- Not Available
- Clearance
- Not Available
- Toxicity
- Not Available
- Affected organisms
- Humans and other mammals
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
References
- General References
- Not Available
- External Links
- PubChem Substance
- 46506183
- PharmGKB
- PA164749508
- Wikipedia
- Sinecatechins
- ATC Codes
- D06BB12 — Sinecatechins
- AHFS Codes
- 84:04.06 — Antivirals
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 1 Completed Treatment External Genital Warts 1 2, 3 Completed Treatment Basal Cell Carcinoma (BCC) 1 Not Available Completed Treatment External Genital Warts 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Doak Dermatologics
- Dosage forms
Form Route Strength Ointment Topical 10 % Ointment Topical 150 mg/g - Prices
Unit description Cost Unit Veregen 15% ointment 19.86USD g DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.- Patents
Patent Number Pediatric Extension Approved Expires (estimated) US5795911 No 2000-10-31 2020-10-31 US US5968973 No 1997-04-10 2017-04-10 US US7858662 No 2006-10-02 2026-10-02 US US9770406 No 2005-07-12 2025-07-12 US
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
- Not Available
- Predicted ADMET features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Taxonomy
- Classification
- Not classified
Drug created on May 16, 2007 14:06 / Updated on April 17, 2018 01:05